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Cell No. : Cell Name
HPS0063 : 201B7  update : 2022/10/13
CommentHuman iPS cell line. HPS0002, HPS0063, HPS0076, HPS0296, HPS0326, HPS3668, HPS4290, HPS4291, HPS4292 were derived from the same person. Feeder-less 201B7 is also available as HPS4290 : 201B7-Ff. "
Comment from the depositor
Terms and conditions1) In relation to the for-profit organizations, please contact iPS Academia Japan, Inc., prior to the utilization of iPS cells. 2) Attach Appendix (non-for-profit) or Appendix (for-profit) to MTA (C-0007 or C-0007p) .
Remarks
Order Form Order Form(C-0042.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor https://www.cira.kyoto-u.ac.jp/
Originator Yamanaka, Shinya
Year of deposit 2011
Another name HPS0001 201B7
Animal human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Female
Age at sampling 36 years
Tissue skin
Classification iPS
Recombinant recombinant
Exogene pMXs-Oct3/4, -Sox2, -Klf4, -c-Myc, pLenti6/UbC/V5-DEST, mouse Slc7a1
Lifespan infinite
Morphology ES-like
Cellosaurus(Expasy) CVCL_A324
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives Primate ES Cell Medium + 4ng/ml human basic FGF
Antibiotics Free
Passage method 0.25% Trypsin + 0.1% collagenase type IV + 20% KSR + 1mM CaCl2 + PBS(-)
Coating dish 0.1% gelatin coated dish
Culture information Passage ratio 1 : 3-6 split
SC frequency Subculture : once/4-6 days, Medium Renewal : every day
Temperature 37 ℃
CO2 concentration 5 %
Feeder cells SNL 76/7
Feeder treatment X-rays 5000R (or MMC)
Feeder seed cells 1.5-2.5 x 10^(6) cells/100 mm dish
Freeze medium DAP213 : Medium + 2M DMSO + 1M Acetamide + 3M Propyleneglycol
Freezing method Vitrification
Mycoplasma (-)
Chromosome mode 46,XX[20] at passage No. 22
STR(human) OK
Images
deposit info
lot info
Relational File deposit infolot info
SDS_DAP(MEM)_Japanese.pdf
Reference information Reference 2
User's Publication 259


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Reference
20937  Tsujimoto H, Katagiri N, Ijiri Y, Sasaki B, Kobayashi Y, Mima A, Ryosaka M, Furuyama K, Kawaguchi Y, Osafune K.  In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells.  PLoS One  2022  17(11)6:e0275600  PubMed ID: 36378656   DOI: 10.1371/journal.pone.0275600
3675  Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S.  Induction of pluripotent stem cells from adult human fibroblasts by defined factors.  Cell  2007  131(5):861-72  PubMed ID: 18035408   DOI: 10.1016/j.cell.2007.11.019

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User's Publication
20537  Nakatani E, Okajima R, Ohnuma K.  Slow diffusion on the monolayer culture enhances auto/paracrine effects of Noggin in differentiation of human iPS cells induced by BMP.  Biochem Biophys Rep  2022  29:101195  PubMed ID: 35005256   DOI: 10.1016/j.bbrep.2021.101195
20566  Kanno S, Okubo Y, Kageyama T, Yan L, Kitajima S, Fukuda J.  Establishment of a developmental toxicity assay based on human iPSC reporter to detect FGF signal disruption.  iScience  2022  25(2):103770  PubMed ID: 35146387   DOI: 10.1016/j.isci.2022.103770
20530  Kanno S, Okubo Y, Kageyama T, Yan L, Fukuda J.  Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals.  J Biosci Bioeng  2022    PubMed ID: 35034848   DOI: 10.1016/j.jbiosc.2021.12.006
20579  Uno N, Takata S, Komoto S, Miyamoto H, Nakayama Y, Osaki M, Mayuzumi R, Miyazaki N, Hando C, Abe S, Sakuma T, Yamamoto T, Suzuki T, Nakajima Y, Oshimura M, Tomizuka K, Kazuki Y.  Panel of human cell lines with human/mouse artificial chromosomes.  Sci Rep  2022  12(1):3009  PubMed ID: 35194085   DOI: 10.1038/s41598-022-06814-3
16355  Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori  Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats  Regen Ther  2022  19:77-87  PubMed ID: 35097166   DOI: 10.1016/j.reth.2022.01.001
16361  Takahashi H, Oikawa F, Takeda N, Shimizu T.  Contraction Control of Aligned Myofiber Sheet Tissue by Parallel Oriented iPS Cell-derived Neurons  Tissue Eng Part A  2022  Jan 21  PubMed ID: 35057641   DOI: 10.1089/ten.TEA.2021.0202
20587  Uehara K, Koyanagi-Aoi M, Koide T, Itoh T, Aoi T.  Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids.  Stem Cell Reports  2022    PubMed ID: 35245440   DOI: 10.1016/j.stemcr.2022.02.002
16439  Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Yada Y, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Tsujikawa A, Inoue H.  One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors  iScience   2022  25(4):103987.  PubMed ID: 35330684   DOI: 10.1016/j.isci.2022.103987
20662  Hayashi R, Okubo T, Kudo Y, Ishikawa Y, Imaizumi T, Suzuki K, Shibata S, Katayama T, Park SJ, Young RD, Quantock AJ, Nishida K.  Generation of 3D lacrimal gland organoids from human pluripotent stem cells.  Nature  2022    PubMed ID: 35444274   DOI: 10.1038/s41586-022-04613-4
20683  Sanaki-Matsumiya M, Matsuda M, Gritti N, Nakaki F, Sharpe J, Trivedi V, Ebisuya M.  Periodic formation of epithelial somites from human pluripotent stem cells.  Nat Commun  2022  13(1):2325  PubMed ID: 35484123   DOI: 10.1038/s41467-022-29967-1
16448  Suzuki T, Furuhata E, Maeda S, Kishima M, Miyajima Y, Tanaka Y, Lim J, Nishimura H, Nakanishi Y, Shojima A, Suzuki H.  GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation  Commun Biol  2022  ;5(1):414  PubMed ID: 35508708   DOI: 10.1038/s42003-022-03365-1
20670  Saito Y, Yamanaka S, Matsumoto N, Takamura T, Fujimoto T, Matsui K, Tajiri S, Matsumoto K, Kobayashi E, Yokoo T.  Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche.  Cell Rep  2022  39(11):110933  PubMed ID: 35705028   DOI: 10.1016/j.celrep.2022.110933
16780  Miura K, Matsuura K, Yamasaki Itoyama Y, Sasaki D, Takada T, Furutani Y, Hayama E, Ito M, Nomura S, Morita H, Toyoda M, Umezawa A, Onoue K, Saito Y, Aburatani H, Nakanishi T, Hagiwara N, Komuro I, Shimizu T.  Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy  Int Heart J  2022  63(2):338-346  PubMed ID: 35354754   DOI: 10.1536/ihj.21-790
20780  Sim EZ, Enomoto T, Shiraki N, Furuta N, Kashio S, Kambe T, Tsuyama T, Arakawa A, Ozawa H, Yokoyama M, Miura M, Kume S.  Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization.  Cell Rep  2022  40(3):111120  PubMed ID: 35858556   DOI: 10.1016/j.celrep.2022.111120
16836  Koide T, Koyanagi-Aoi M, Uehara K, Kakeji Y, Aoi T.  CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells  iScience  2022  25(5):104314  PubMed ID: 35602937   DOI: 10.1016/j.isci.2022.104314
16845  Morimoto Y, Tokumitsu A, Sone T, Hirota Y, Tamura R, Sakamoto A, Nakajima K, Toda M, Kawakami Y, Okano H, Ohta S.  TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF)  Neurochem Res  2022  May 27  PubMed ID: 35622214   DOI: 10.1007/s11064-022-03629-6
20795  Kanno S, Mizota K, Okubo Y, Kageyama T, Yan L, Fukuda J.  Luciferase assay system to monitor fibroblast growth factor signal disruption in human iPSCs.  3(2):101439  2022    PubMed ID: 35677614   DOI: 10.1016/j.xpro.2022.101439
20850  Tanaka H, Tsuji D, Watanabe R, Ohnishi Y, Kitaguchi S, Nakae R, Teramoto H, Tsukimoto J, Horii Y, Itoh K.  Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis.  J Inherit Metab Dis  2022    PubMed ID: 36102069   DOI: 10.1002/jimd.12558
20865  Nakashima Y, Miyagi-Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, Noguchi H.  Induced hepatic stem cells are suitable for human hepatocyte production.  iScience  2022  25(10):105052  PubMed ID: 36147945   DOI: 10.1016/j.isci.2022.105052
17191  Yamamoto T, Arita M, Kuroda H, Suzuki T, Kawamata S.  Improving the differentiation potential of pluripotent stem cells by optimizing culture conditions  Sci Rep  2022  12(1):14147  PubMed ID: 35986054   DOI: 10.1038/s41598-022-18400-8
20931  Shoji M, Kuzuhara T.  Imaging Analysis of Neurotrophic Effects by CCN2 Protein in Neuronal Precursor Cells Derived from Human-Induced Pluripotent Stem Cells.  Methods Mol Biol  2022  2582:269-280  PubMed ID: 36370356   DOI: 10.1007/978-1-0716-2744-0_18
20936  Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S.  A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population.  Med (N Y)  2022    PubMed ID: 36395757   DOI: 10.1016/j.medj.2022.10.003
12197  Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki  Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons  EBioMedicine  2021  63:103138  PubMed ID: 33341442   DOI: 10.1016/j.ebiom.2020.103138
13237  Watanabe T, Yasuda S, Kusakawa S, Kuroda T, Futamura M, Ogawa M, Mochizuki H, Kikkawa E, Furukawa H, Nagaoka M, Sato Y.  Multisite studies for validation and improvement of a highly efficient culture assay for detection of undifferentiated human pluripotent stem cells intermingled in cell therapy products.  Cytotherapy  2021    PubMed ID: 32978066   DOI: 10.1016/j.jcyt.2020.07.009
13380  Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y.  Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication.  FEBS Open Bio  2021  11(2):354-366  PubMed ID: 33301617   DOI: 10.1002/2211-5463.13060
20030  Yamanaka S, Matsui K, Fujimoto T, Takamura T, Saito Y, Matsumoto N, Tajiri S, Matsumoto K, Yokoo T.  In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation.  STAR Protoc  2021  2(1):100314  PubMed ID: 33554147   DOI: 10.1016/j.xpro.2021.100314
20034  Nomi K, Hayashi R, Ishikawa Y, Kobayashi Y, Katayama T, Quantock AJ, Nishida K.  Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs.  Cell Rep  2021  34(5):108715  PubMed ID: 33535050   DOI: 10.1016/j.celrep.2021.108715
20051  Oyane A, Araki H, Nakamura M, Aiki Y, Ito Y.  Storable bFGF-Releasing Membrane Allowing Continuous Human iPSC Culture.  Materials (Basel)  2021  14(3)  PubMed ID: 33572553   DOI: 10.3390/ma14030651
20129  Hasegawa-Ogawa M, Okano HJ.  Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein.  Sci Rep  2021  11(1):8720  PubMed ID: 33888768   DOI: 10.1038/s41598-021-88015-y
20132  Akagi Y, Mori N, Kawamura T, Takayama Y, Kida YS.  Non-invasive cell classification using the Paint Raman Express Spectroscopy System (PRESS).  Sci Rep  2021  11(1):8818  PubMed ID: 33893362   DOI: 10.1038/s41598-021-88056-3
14073  Watanabe T, Tateno H.  Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody  Biochem Biophys Res Commun  2021  554:13-18  PubMed ID: 33774274   DOI: 10.1016/j.bbrc.2021.03.078
14074  Mu A, Hira A, Niwa A, Osawa M, Yoshida K, Mori M, Okamoto Y, Inoue K, Kondo K, Kanemaki MT, Matsuda T, Ito E, Kojima S, Nakahata T, Ogawa S, Tanaka K, Matsuo K, Saito MK, Takata M.  Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency  Blood  2021  137(15):2021-2032  PubMed ID: 33512438   DOI: 10.1182/blood.2020009111
14076  Li J, Lee JK, Miwa K, Kuramoto Y, Masuyama K, Yasutake H, Tomoyama S, Nakanishi H, Sakata Y.  Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal  Front Cell Dev Biol  2021  9:591754  PubMed ID: 33659246   DOI: 10.3389/fcell.2021.591754
20141  Yasutake H, Lee JK, Hashimoto A, Masuyama K, Li J, Kuramoto Y, Higo S, Hikoso S, Hidaka K, Naito AT, Miyagawa S, Sawa Y, Komuro I, Sakata Y.  Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes.  Sci Rep  2021  11(1):10351  PubMed ID: 33990626   DOI: 10.1038/s41598-021-89603-8
20144  Fukunaga I, Oe Y, Danzaki K, Ohta S, Chen C, Shirai K, Kawano A, Ikeda K, Kamiya K.  Modeling gap junction beta 2 gene-related deafness with human iPSC.  Hum Mol Genet  2021    PubMed ID: 33997905   DOI: 10.1093/hmg/ddab097
20221  Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, Kawamura Y, Ueda Y, Takai H, Mandai M, Kondoh E.  Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells  Sci Rep  2021  11(1):14167  PubMed ID: 34239021   DOI: 10.1159/000253996
20303  Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K.  Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities.  iScience  2021  24(6):102688  PubMed ID: 34195566   DOI: 10.1016/j.isci.2021.102688
20318  Hori Y, Shimamoto A, Kobayashi T.  The human ribosomal DNA array is composed of highly homogenized tandem clusters.  Genome Res  2021    PubMed ID: 34407983   DOI: 10.1101/gr.275838.121
15460  Minoshima F, Ozaki H, Odaka H, Tateno H.  Integrated analysis of glycan and RNA in single cells  iScience  2021  24(8):102882  PubMed ID: 34401666   DOI: 10.1016/j.isci.2021.102882
15519  Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa YS, Gotoh S.  Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology  Sci Transl Med  2021  13(601):eabb1298  PubMed ID: 34233948   DOI: 10.1126/scitranslmed.abb1298
15522  Kikuchi T, Matsuura K, Shimizu T.  Non-coating method for non-adherent cell culture using high molecular weight dextran sulfate and bovine serum albumin  J Biosci Bioeng  2021  S1389-1723(21)00209-7  PubMed ID: 34518107   DOI: 10.1016/j.jbiosc.2021.08.006
15525  Horikawa A, Mizuno K, Tsuda K, Yamamoto T, Michiue T.  A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox  PLoS One  2021  16(7):e0254373  PubMed ID: 34252142   DOI: 10.1371/journal.pone.0254373
20435  Miyake T, Kuge M, Matsumoto Y, Shimada M.  α-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells.  Stem Cell Res  2021  56:102511  PubMed ID: 34455240   DOI: 10.1016/j.scr.2021.102511
15884  Akihiro Morita, Yuta Omoya, Rie Ito, Yuya Ishibashi, Keiichi Hiramoto, Shiho Ohnishi, Nobuji Yoshikawa, Shosuke Kawanishi  Glycyrrhizin and its derivatives promote hepatic differentiation via sweet receptor, Wnt, and Notch signaling  Biochemistry and Biophysics Reports  2021  28:101181    DOI: 10.1016/j.bbrep.2021.101181
20474  Chu SL, Abe K, Yokota H, Cho D, Chen YH, Tsai MD.  High Resolution U-Net for Quantitatively Analyzing Early Spatial Patterning of Human Induced Pluripotent Stem Cells on Micropatterns.  Annu Int Conf IEEE Eng Med Biol Soc  2021  3713-3716  PubMed ID: 34892043   DOI: 10.1109/EMBC46164.2021.9630956
20491  Tadokoro S, Tokuyama-Toda R, Tatehara S, Ide S, Umeki H, Miyoshi K, Noma T, Satomura K.  A New Induction Method for the Controlled Differentiation of Human-Induced Pluripotent Stem Cells Using Frozen Sections.  Cells  2021  10(11)  PubMed ID: 34831050   DOI: 10.3390/cells10112827
20508  Lee HS, Mok J, Joo CK.  Bone Morphogenetic Protein 4 (BMP4) Enhances the Differentiation of Human Induced Pluripotent Stem Cells into Limbal Progenitor Cells.  Curr Issues Mol Biol  2021  43(3):2124-2134  PubMed ID: 34940121   DOI: 10.3390/cimb43030147
16880  Taniguchi-Ikeda M, Koyanagi-Aoi M, Maruyama T, Takaori T, Hosoya A, Tezuka H, Nagase S, Ishihara T, Kadoshima T, Muguruma K, Ishigaki K, Sakurai H, Mizoguchi A, Novitch BG, Toda T, Watanabe M, Aoi T.  Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy  iScience  2021  24(10):103140  PubMed ID: 34632335   DOI: 10.1016/j.isci.2021.103140
11778  Tateno H, Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y.  Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants.  J. Biosci. Bioeng.  2020  129(2):215-222.  PubMed ID: 31473147   DOI: 10.1016/j.jbiosc.2019.08.003
11841  Yoda K, Ohnuki Y, Masui S, Kurosawa H.  Optimized conditions for the supplementation of human-induced pluripotent stem cell cultures with a GSK-3 inhibitor during embryoid body formation with the aim of inducing differentiation into mesodermal and cardiac lineage.  J. Biosci. Bioeng.  2020    PubMed ID: 31615734   DOI: 10.1016/j.jbiosc.2019.09.015
11879  Morishige S, Mizuno S, Ozawa H, Nakamura T, Mazahery A, Nomura K, Seki R, Mouri F, Osaki K, Yamamura K, Okamura T, Nagafuji K.  CRISPR/Cas9-mediated gene correction in hemophilia B patient-derived iPSCs.  Int. J. Hematol.  2020    PubMed ID: 31664646   DOI: 10.1007/s12185-019-02765-0
6879  Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H.  Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells.  Cell Rep  2020  30(1):18-24  PubMed ID: 31914385   DOI: 10.1016/j.celrep.2019.12.009
9933  Shun Shibata, Ryuhei Hayashi, Yuji Kudo, Toru Okubo, Tsutomu Imaizumi, Tomohiko Katayama, Yuki Ishikawa, Yuki Kobayashi, Junko Toga, Yukimasa Taniguchi, Yoichi Honma, Kiyotoshi Sekiguchi, Kohji Nishida  Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium  Stem Cell Reports  2020  14(4):663-676  PubMed ID: 32197114   DOI: 10.1016/j.stemcr.2020.02.008
11938  Hashida A, Uemura T, Kino-Oka M.  Kinetics on aggregate behaviors of human induced pluripotent stem cells in static suspension and rotating flow cultures.  J. Biosci. Bioeng.  2020    PubMed ID: 31826834   DOI: 10.1016/j.jbiosc.2019.11.005
12000  Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S.  Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers.  Regen Ther  2020    PubMed ID: 31988991   DOI: 10.1016/j.reth.2019.12.010
12042  Ninomiya H, Intoh A, Ishimine H, Onuma Y, Ito Y, Michiue T, Tazaki A, Kato M.  Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals.  Chemosphere  2020    PubMed ID: 32092576   DOI: 10.1016/j.chemosphere.2020.126124
12079  Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K.  Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells.  Sci Rep  2020    PubMed ID: 32152328   DOI: 10.1038/s41598-020-60036-z
12141  Ayako Oyane, Hiroko Araki, Maki Nakamura, Yasuhiko Aiki, Kumiko Higuchi, Alexander Pyatenko, Masaki Adachi and Yuzuru Ito  Controlled release of basic fibroblast growth factor from a water-floatable polyethylene nonwoven fabric sheet for maintenance culture of iPSCs  RSC Advances  2020      DOI: 10.1039/C9RA06906B
13105  Takayama Y, Kushige H, Akagi Y, Suzuki Y, Kumagai Y, Kida YS.  Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating.  Sci Rep  2020    PubMed ID: 32528170   DOI: 10.1038/s41598-020-66303-3
13124  Watanabe T, Saito S, Hiemori K, Kiyoi K, Mawaribuchi S, Haramoto Y, Tateno H.  SSEA-1-positive fibronectin is secreted by cells deviated from the undifferentiated state of human induced pluripotent stem cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32736676   DOI: 10.1016/j.bbrc.2020.06.074
13166  Ito A, Yoshioka K, Masumoto S, Sato K, Hatae Y, Nakai T, Yamazaki T, Takahashi M, Tanoue S, Horie M.  Magnetic heating of nanoparticles as a scalable cryopreservation technology for human induced pluripotent stem cells.  Sci Rep  2020    PubMed ID: 32788637   DOI: 10.1038/s41598-020-70707-6
13213  Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H.  Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32912628   DOI: 10.1016/j.bbrc.2020.08.092
13218  Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto N, Matsumoto K, Tachibana T, Okano HJ, Yokoo T.  Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System.  Cell Rep  2020    PubMed ID: 32937125   DOI: 10.1016/j.celrep.2020.108130
13370  Xu L, Hanamatsu H, Homan K, Onodera T, Miyazaki T, Furukawa JI, Hontani K, Tian Y, Baba R, Iwasaki N.  Alterations of Glycosphingolipid Glycans and Chondrogenic Markers during Differentiation of Human Induced Pluripotent Stem Cells into Chondrocytes.  Biomolecules  2020    PubMed ID: 33271874   DOI: 10.3390/biom10121622
13487  Hidaka T, Tsubono Y, Hashiya K, Bando T, Pandian GN, Sugiyama H.  Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector  Chem Commun (Camb)  2020  56(82):12371-12374  PubMed ID: 32930253   DOI: 10.1039/d0cc05158f
13607  Nakamura T, Morishige S, Ozawa H, Kuboyama K, Yamasaki Y, Oya S, Yamaguchi M, Aoyama K, Seki R, Mouri F, Osaki K, Okamura T, Mizuno S, Nagafuji K.  Successful correction of factor V deficiency of patient-derived iPSCs by CRISPR/Cas9-mediated gene editing  Haemophilia  2020  26(5):826-833  PubMed ID: 32700411   DOI: 10.1111/hae.14104
13615  Tateno H.  Expression and Purification of a Human Pluripotent Stem Cell-Specific Lectin Probe, rBC2LCN  Methods Mol Biol  2020  2132:453-461  PubMed ID: 32306352   DOI: 10.1007/978-1-0716-0430-4_44
13782  Homma J, Shimizu S, Sekine H, Matsuura K, Shimizu T.  A novel method to align cells in a cardiac tissue-like construct fabricated by cell sheet-based tissue engineering  J Tissue Eng Regen Med  2020  14(7):944-954  PubMed ID: 32478904   DOI: 10.1002/term.3074
14604  Sakaguchi K, Takahashi H, Tobe Y, Sasaki D, Matsuura K, Iwasaki K, Shimizu T, Umezu M.  Measuring the Contractile Force of Multilayered Human Cardiac Cell Sheets  Tissue Eng Part C Methods  2020  26(9):485-492  PubMed ID: 32799760   DOI: 10.1089/ten.TEC.2020.0164
11235  Yoda K, Ohnuki Y, Kurosawa H.  Optimization of the treatment conditions with glycogen synthase kinase-3 inhibitor towards enhancing the proliferation of human induced pluripotent stem cells while maintaining an undifferentiated state under feeder-free conditions.  J. Biosci. Bioeng.  2019  127(3):381-387  PubMed ID: 30292671   DOI: 10.1016/j.jbiosc.2018.09.002
11391  Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H, Narita M.  Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations.  Mol Brain  2019    PubMed ID: 30658665   DOI: 10.1186/s13041-019-0426-7
11424  Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H.  Photoactivable elimination of tumorigenic human induced pluripotent stem cells using a lectin-doxorubicin prodrug conjugate.  Chembiochem  2019    PubMed ID: 30737871   DOI: 10.1002/cbic.201900086
11468  Kono K, Sawada R, Kuroda T, Yasuda S, Matsuyama S, Matsuyama A, Mizuguchi H, Sato Y.  Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells.  Sci Rep  2019    PubMed ID: 30842516   DOI: 10.1038/s41598-018-36848-5
4572  Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, Miura T, Matsuyama A, Sato Y.  SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation.  Nat Commun  2019  10(1):2175  PubMed ID: 31092818   DOI: 10.1038/s41467-019-09511-4
11516  Matsushita S, Kajiwara T, Mizumoto H.  Expansion and differentiation of human iPS cells in a three-dimensional culture using hollow fibers and separation of the specific population by magnetic-activated cell sorting.  J. Biosci. Bioeng.  2019    PubMed ID: 30982708   DOI: 10.1016/j.jbiosc.2019.03.014
11531  Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M.  Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease.  Brain  2019    PubMed ID: 31135049   DOI: 10.1093/brain/awz084
11576  Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y, Tomonaga K.  RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs.  Mol Ther Methods Clin Dev  2019  14:47-55  PubMed ID: 31309127   DOI: 10.1016/j.omtm.2019.05.010
11653  Nao Yamaoka, Kazunori Shimizu, Yu Imaizumi, Takuji Ito, Yohei Okada, Hiroyuki Honda  Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions  BioChip Journal  2019      DOI: 10.1007/s13206-018-3202-3
11679  Sachiko Sekiya, Tetsutaro Kikuchi, Tatsuya Shimizu  Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro  BMC Biomedical Engineering  2019      DOI: 10.1186/s42490-019-0017-9
11788  Shoji M, Ueda M, Nishioka M, Minato H, Seki M, Harada K, Kubo M, Fukuyama Y, Suzuki Y, Aoyama E, Takigawa M, Kuzuhara T.  Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31506177   DOI: 10.1016/j.bbrc.2019.09.003
11798  Sugawara Y, Hamada K, Yamada Y, Kumai J, Kanagawa M, Kobayashi K, Toda T, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Kikkawa Y.  Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment.  Sci Rep  2019    PubMed ID: 31506597   DOI: 10.1038/s41598-019-49669-x
11875  Shimada M, Tsukada K, Kagawa N, Matsumoto Y.  Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells.  J. Radiat. Res.  2019    PubMed ID: 31665364   DOI: 10.1093/jrr/rrz057
10103  Tomoko Miyake, Mikio Shimada, Yoshihisa Matsumoto, Akitoshi Okino  DNA Damage Response After Ionizing Radiation Exposure in Skin Keratinocytes Derived From Human-Induced Pluripotent Stem Cells  Int J Radiat Oncol Biol Phys .  2019  105(1):193-205  PubMed ID: 31085283   DOI: 10.1016/j.ijrobp.2019.05.006
11968  Hayakawa K, Nishitani K, Tanaka S.  Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci.  Sci Rep  2019    PubMed ID: 31875008   DOI: 10.1038/s41598-019-56341-x
12138  Takayuki Nakamura, MD, Shinichi Mizuno, MD PhD, Hidetoshi Ozawa, Yoshitaka Yamasaki, MD, Shuki Oya, MD, Satoshi Morishige, MD, Kazutoshi Aoyama, MD PhD, Maki Ymaguchi, MD PhD, Ritsuko Seki, PhD, Fumihiko Mouri, MD PhD, Koichi Osaki, MD, Koji Nagafuji, MD PhD  A Functional Analysis of SNP on Anthracycline-Induced Cardiotoxicity in a Uniform Genetic Background Using CRISPR/Cas9 Mediated Single-Base-Edited iPSCs  Blood   2019      DOI: 10.1182/blood-2019-123932
12334  Wei H, Wang C, Guo R, Takahashi K, Naruse K.  Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells  Biochem Biophys Res Commun  2019  520(3):600-605  PubMed ID: 31623826   DOI: 10.1016/j.bbrc.2019.09.119
12355  Okuyama H, Ohnishi H, Nakamura R, Yamashita M, Kishimoto Y, Tateya I, Suehiro A, Gotoh S, Takezawa T, Nakamura T, Omori K.  Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea  J Tissue Eng Regen Med  2019  13(6):1019-1030  PubMed ID: 30809958   DOI: 10.1002/term.2849
12356  Tsuruyama S, Matsuura K, Sakaguchi K, Shimizu T.  Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets  Regen Ther  2019  11:297-305  PubMed ID: 31667209   DOI: 10.1016/j.reth.2019.09.001
12357  Inui A, Sekine H, Sano K, Dobashi I, Yoshida A, Matsuura K, Kobayashi E, Ono M, Shimizu T.  Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue  Regen Ther  2019  11:316-323  PubMed ID: 31687425   DOI: 10.1016/j.reth.2019.10.001
12358  Ito E, Miyagawa S, Takeda M, Kawamura A, Harada A, Iseoka H, Yajima S, Sougawa N, Mochizuki-Oda N, Yasuda S, Sato Y, Sawa Y.  Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application  Sci Rep  2019  9(1):1881  PubMed ID: 30760836   DOI: 10.1038/s41598-018-38325-5
16886  Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, Shimmura S, Sugita S.  Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells  Stem Cells Dev  2019  28(1):28-43  PubMed ID: 30251915   DOI: 10.1089/scd.2018.0058
16889  Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S, Hidaka K, Miyagawa S, Sawa Y, Komuro I, Sakata Y.  Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias  Front Physiol  2019  10:818  PubMed ID: 31316396   DOI: 10.3389/fphys.2019.00818
7001  Akiyama T, Sato S, Chikazawa-Nohtomi N, Soma A, Kimura H, Wakabayashi S, Ko SBH, Ko MSH.  Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing.  Sci Rep  2018  8:1189  PubMed ID: 29352121   DOI: 10.1038/s41598-017-19114-y
7003  Yamamoto T, Takenaka C, Yoda Y, Oshima Y, Kagawa K, Miyajima H, Sasaki T, Kawamata S.  Differentiation potential of Pluripotent Stem Cells correlates to the level of CHD7.  Sci Rep  2018  8:241  PubMed ID: 29321579   DOI: 10.1038/s41598-017-18439-y
10630  Matsumura W, Fujita Y, Nakayama C, Shinkuma S, Suzuki S, Nomura T, Abe R, Shimizu H.  Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes.  J. Dermatol. Sci.  2018  89:263-271  PubMed ID: 29229433   DOI: 10.1016/j.jdermsci.2017.11.017
10758  Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M.  Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction.  Mol Brain  2018  11:6  PubMed ID: 29458391   DOI: 10.1186/s13041-018-0349-8
10777  Saito S, Hiemori K, Kiyoi K, Tateno H.  Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray.  Sci Rep  2018  8:3997  PubMed ID: 29507392   DOI: 10.1038/s41598-018-22450-2
10813  Sugimoto K, Matsuura T, Nakazono A, Igawa K, Yamada S, Hayashi Y.  Effects of hypoxia inducible factors on pluripotency in human iPS cells.  Microsc. Res. Tech.  2018  81(7):749-754  PubMed ID: 29633433   DOI: 10.1002/jemt.23032
10815  Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK.  Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease.  Nat Commun  2018  9:1479  PubMed ID: 29662056   DOI: 10.1038/s41467-018-03674-2
10821  Tashiro S, Le MNT, Kusama Y, Nakatani E, Suga M, Furue MK, Satoh T, Sugiura S, Kanamori T, Ohnuma K.  High cell density suppresses BMP4-induced differentiation of human pluripotent stem cells to produce macroscopic spatial patterning in a unidirectional perfusion culture chamber.  J. Biosci. Bioeng.  2018  126(3):379-388  PubMed ID: 29681444   DOI: 10.1016/j.jbiosc.2018.03.007
11055  Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K.  Automated Adherent Cell Elimination by a High-Speed Laser Mediated by a LightResponsive Polymer  Commun Biol  2018  1:218  PubMed ID: 30534610   DOI: 10.1038/s42003-018-0222-4
11135  Arioka Y, Shishido E, Kubo H, Kushima I, Yoshimi A, Kimura H, Ishizuka K, Aleksic B, Maeda T, Ishikawa M, Kuzumaki N, Okano H, Mori D, Ozaki N.  Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant.  Transl Psychiatry  2018  8(1):129  PubMed ID: 30022058   DOI: 10.1038/s41398-018-0177-8
11178  Nagashima T, Shimizu K, Matsumoto R, Honda H.  Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine.  Sci Rep  2018  8(1):12427  PubMed ID: 30127448   DOI: 10.1038/s41598-018-30936-2
11131  Haraguchi Y, Matsuura K, Kagawa Y, Hasegawa A, Kubo H, Shimizu T.  Rapid creation system of morphologically and functionally communicative three-dimensional cell-dense tissue by centrifugation.  Biotechnol. Prog.  2018  34(6):1447-1453  PubMed ID: 30009512   DOI: 10.1002/btpr.2691
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11123  Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H.  A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.  Nat Commun  2018  9(1):2668  PubMed ID: 29991716   DOI: 10.1038/s41467-018-05127-2
11234  Yasuda S, Kusakawa S, Kuroda T, Miura T, Tano K, Takada N, Matsuyama S, Matsuyama A, Nasu M, Umezawa A, Hayakawa T, Tsutsumi H, Sato Y.  Tumorigenicity-associated characteristics of human iPS cell lines.  PLoS ONE  2018    PubMed ID: 30286143   DOI: 10.1371/journal.pone.0205022
4048  Shibata S, Hayashi R, Okubo T, Kudo Y, Katayama T, Ishikawa Y, Toga J, Yagi E, Honma Y, Quantock AJ, Sekiguchi K, Nishida K.  Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages  Cell Rep  2018  25(6):1668-1679  PubMed ID: 30404017   DOI: 10.1016/j.celrep.2018.10.032
11240  Tajiri S, Yamanaka S, Fujimoto T, Matsumoto K, Taguchi A, Nishinakamura R, Okano HJ, Yokoo T.  Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration.  Sci Rep  2018    PubMed ID: 30297790   DOI: 10.1038/s41598-018-33256-7
11251  Murata H, Khine CC, Nishikawa A, Yamamoto KI, Kinoshita R, Sakaguchi M.  c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration.  J. Biol. Chem.  2018    PubMed ID: 30333228   DOI: 10.1074/jbc.RA118.004578
11290  Hayashi R, Ishikawa Y, Katayama T, Quantock AJ, Nishida K.  CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells.  Sci Rep  2018    PubMed ID: 30410112   DOI: 10.1038/s41598-018-34845-2
4068  Takako Tsugata, Naruo Nikoh, Tatsuya Kin, Chika Miyagi-Shiohira, Yoshiki Nakashima, Issei Saitoh, Yasufumi Noguchi, Hideo Ueki, Masami Watanabe6 Naoya Kobayashi, Andrew M. James Shapiro2 Hirofumi Noguchi  Role of Egr1 on Pancreatic Endoderm Differentiation  Cell Medicine  2018  10  PubMed ID: 32634182   DOI: 10.1177/2155179017733177
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4112  Tachikawa S, Shimizu M, Maruyama K, Ohnuma K.  Thalidomide induces apoptosis during early mesodermal differentiation of human induced pluripotent stem cells.  In Vitro Cell. Dev. Biol. Anim.  2018    PubMed ID: 29435726   DOI: 10.1007/s11626-018-0234-x
4113  Shoji M, Minato H, Ogaki S, Seki M, Suzuki Y, Kume S, Kuzuhara T.  Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells.  PLoS ONE  2018    PubMed ID: 30048506   DOI: 10.1371/journal.pone.0201239
4114  Eto S, Goto M, Soga M, Kaneko Y, Uehara Y, Mizuta H, Era T.  Mesenchymal stem cells derived from human iPS cells via mesoderm and neuroepithelium have different features and therapeutic potentials.  PLoS ONE  2018    PubMed ID: 30044827   DOI: 10.1371/journal.pone.0200790
4115  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells.  Oncol Lett  2018    PubMed ID: 30250594   DOI: 10.3892/ol.2018.9292
4456  Matsuura K, Ito K, Shiraki N, Kume S, Hagiwara N, Shimizu T.  Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42°C Condition for Tumor Prevention.  Tissue Eng Part C Methods  2018  24(10):605-615  PubMed ID: 30234460   DOI: 10.1089/ten.TEC.2018.0228
4457  Kikuchi T, Kino-Oka M, Wada M, Kobayashi T, Kato M, Takeda S, Kubo H, Ogawa T, Sunayama H, Tanimoto K, Mizutani M, Shimizu T, Okano T.  A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory.  Regen Ther  2018  9:89-99  PubMed ID: 30525079   DOI: 10.1016/j.reth.2018.08.004
4458  Kobayashi H, Ebisawa K, Kambe M, Kasai T, Suga H, Nakamura K, Narita Y, Ogata A, Kamei Y.  <Editors' Choice> Effects of exosomes derived from the induced pluripotent stem cells on skin wound healing.  Nagoya J Med Sci  2018  80(2):141-153  PubMed ID: 29915432   DOI: 10.18999/nagjms.80.2.141
4459  Sasaki D, Matsuura K, Seta H, Haraguchi Y, Okano T, Shimizu T.  Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue.  PLoS ONE  2018  13(5):e0198026  PubMed ID: 29791489   DOI: 10.1371/journal.pone.0198026
4460  Hamano S, Tomokiyo A, Hasegawa D, Yoshida S, Sugii H, Mitarai H, Fujino S, Wada N, Maeda H.  Extracellular Matrix from Periodontal Ligament Cells Could Induce the Differentiation of Induced Pluripotent Stem Cells to Periodontal Ligament Stem Cell-Like Cells.  Stem Cells Dev.  2018  27(2):100-111  PubMed ID: 29160151   DOI: 10.1089/scd.2017.0077
4461  Matsuda Y, Takahashi K, Kamioka H, Naruse K.  Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes.  Biochem. Biophys. Res. Commun.  2018  503(3):1798-1804  PubMed ID: 30060947   DOI: 10.1016/j.bbrc.2018.07.116
5773  Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M.  A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin.  Biotechnol J  2018  13(2)  PubMed ID: 29027750   DOI: 10.1002/biot.201700384
5775  Kobayashi W, Onishi A, Tu HY, Takihara Y, Matsumura M, Tsujimoto K, Inatani M, Nakazawa T, Takahashi M.  Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning.  Invest Ophthalmol Vis Sci  2018  59(2):776-787  PubMed ID: 29392326   DOI: 10.1167/iovs.17-22406
5776  Sumaru K, Takagi T, Morishita K, Kanamori T.  Photoresponsive Aqueous Dissolution of Poly( N-Isopropylacrylamide) Functionalized with o-Nitrobenzaldehyde through Phase Transition.  Biomacromolecules  2018  19(7):2913-2922  PubMed ID: 29641886   DOI: 10.1021/acs.biomac.8b00470
5777  Nakashima Y, Miyagi-Shiohira C, Noguchi H2, Omasa T.  Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells.  Mol Ther  2018  26(7):1715-1734  PubMed ID: 29929789   DOI: 10.1016/j.ymthe.2018.06.005
14923  Nakayama C, Fujita Y, Matsumura W, Ujiie I, Takashima S, Shinkuma S, Nomura T, Abe R, Shimizu H.  The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes  J Dermatol Sci  2018  91(3):301-310  PubMed ID: 29933899   DOI: 10.1016/j.jdermsci.2018.06.004
7014  Taguchi A, Nishinakamura R.  Higher-Order Kidney Organogenesis from Pluripotent Stem Cells.  Cell Stem Cell  2017  21(6):730-746  PubMed ID: 29129523   DOI: 10.1016/j.stem.2017.10.011
7022  Nihongaki Y, Furuhata Y, Otabe T, Hasegawa S, Yoshimoto K, Sato M.  CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation.  Nat. Methods  2017  14:963-966  PubMed ID: 28892089   DOI: 10.1038/nmeth.4430
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9842  Ozeki N, Hase N, Higuchi N, Hiyama T, Yamaguchi H, Kawai R, Matsumoto T, Nakata K, Mogi M.  Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells.  Differentiation  2017  93:1-14  PubMed ID: 27639333   DOI: 10.1016/j.diff.2016.09.002
10099  Ozeki N, Hase N, Hiyama T, Yamaguchi H, Kawai-Asano R, Nakata K, Mogi M.  MicroRNA-211 and autophagy-related gene 14 signaling regulate osteoblast-like cell differentiation of human induced pluripotent stem cells.  Exp. Cell Res.  2017  352:63-74  PubMed ID: 28159471   DOI: 10.1016/j.yexcr.2017.01.018
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10162  Haraguchi Y, Hasegawa A, Matsuura K, Kobayashi M, Iwana SI, Kabetani Y, Shimizu T.  Three-Dimensional Human Cardiac Tissue Engineered by Centrifugation of Stacked Cell Sheets and Cross-Sectional Observation of Its Synchronous Beatings by Optical Coherence Tomography.  Biomed Res Int  2017  2017:5341702  PubMed ID: 28326324   DOI: 10.1155/2017/5341702
10212  Takahashi M, Saito A, Jimbo Y, Nakasono S.  Evaluation of the effects of power-frequency magnetic fields on the electrical activity of cardiomyocytes differentiated from human induced pluripotent stem cells.  J Toxicol Sci  2017  42:223-231  PubMed ID: 28321048   DOI: 10.2131/jts.42.223
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10409  Bamba Y, Kanemura Y, Okano H, Yamasaki M.  Visualization of migration of human cortical neurons generated from induced pluripotent stem cells.  J. Neurosci. Methods  2017  289:57-63  PubMed ID: 28694214   DOI: 10.1016/j.jneumeth.2017.07.004
10426  Tateno H, Saito S.  Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells.  Molecules  2017  22:  PubMed ID: 28698527   DOI: 10.3390/molecules22071151
10447  Taniguchi J, Pandian GN, Hidaka T, Hashiya K, Bando T, Kim KK, Sugiyama H.  A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm.  Nucleic Acids Res.  2017  45:9219-9228  PubMed ID: 28934500   DOI: 10.1093/nar/gkx693
10484  Tachikawa S, Nishimura T, Nakauchi H, Ohnuma K.  Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells.  In Vitro Cell. Dev. Biol. Anim.  2017  53:841-851  PubMed ID: 28849348   DOI: 10.1007/s11626-017-0192-8
10529  Hosoyama T, Ichida S, Kanno M, Ishihara R, Hatashima T, Ueno K, Hamano K.  Microgravity influences maintenance of the human muscle stem/progenitor cell pool.  Biochem. Biophys. Res. Commun.  2017  493:998-1003  PubMed ID: 28942144   DOI: 10.1016/j.bbrc.2017.09.103
10593  Hasegawa D, Ochiai-Shino H, Onodera S, Nakamura T, Saito A, Onda T, Watanabe K, Nishimura K, Ohtaka M, Nakanishi M, Kosaki K, Yamaguchi A, Shibahara T, Azuma T.  Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction.  PLoS ONE  2017  12:e0186879  PubMed ID: 29088246   DOI: 10.1371/journal.pone.0186879
10667  Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu D, Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M.  Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta.  Asian Spine J  2017  11:870-879  PubMed ID: 29279741   DOI: 10.4184/asj.2017.11.6.870
10690  Kavitha MS, Kurita T, Park SY, Chien SI, Bae JS, Ahn BC.  Deep vector-based convolutional neural network approach for automatic recognition of colonies of induced pluripotent stem cells.  PLoS ONE  2017  12:e0189974  PubMed ID: 29281701   DOI: 10.1371/journal.pone.0189974
4551  Hayashi R, Ishikawa Y, Katori R, Sasamoto Y, Taniwaki Y, Takayanagi H, Tsujikawa M, Sekiguchi K, Quantock AJ, Nishida K.  Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells.  Nat Protoc  2017  12(4):683-696  PubMed ID: 28253236   DOI: 10.1038/nprot.2017.007
5760  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  2‑Deoxy‑D‑glucose initiates hepatocyte differentiation in human induced pluripotent stem cells.  Mol Med Rep  2017  15(5):3083-3087  PubMed ID: 28358426   DOI: 10.3892/mmr.2017.6405
5761  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Oncostatin M in William's E medium is suitable for initiation of hepatocyte differentiation in human induced pluripotent stem cells.  Mol Med Rep  2017  15(5):3088-3092  PubMed ID: 28358419   DOI: 10.3892/mmr.2017.6406
5762  Hasehira K, Hirabayashi J, Tateno H.  Structural and quantitative evidence of α2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells.  Glycoconj J  2017  34(6):797-806  PubMed ID: 27314244   DOI: 10.1007/s10719-016-9699-6
5763  K Sumaru et al  Sectioning of cultured cell monolayer using photo-acid-generating substrate and micro-patterned light projection  European Polymer Journal   2017  93:733-742    DOI: 10.1016/j.eurpolymj.2017.02.021
5764  Tani H, Okuda S, Nakamura K, Aoki M, Umemura T.  Short-lived long non-coding RNAs as surrogate indicators for chemical exposure and LINC00152 and MALAT1 modulate their neighboring genes.  PLoS One  2017  12(7):e0181628  PubMed ID: 28719640   DOI: 10.1371/journal.pone.0181628
5765  Tateno H et al  Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media.  Regen Ther  2017  6:1-8  PubMed ID: 30271833   DOI: 10.1016/j.reth.2016.12.002
5766  Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T.  Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs.  Cell Transplant  2017  26(8):1355-1364  PubMed ID: 28901192   DOI: 10.1177/0963689717720280
5767  Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, Nakashima K, Tagawa Y, Okazaki S, Matsuura Y, Wakita T, Suzuki T.  Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation.  Oncotarget  2017  8(33):53899-53915  PubMed ID: 28903311   DOI: 10.18632/oncotarget.19108
5768  Alsayegh K, Matsuura K, Sekine H, Shimizu T.  Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue.  Sci Rep  2017  7:45577  PubMed ID: 28361959   DOI: 10.1038/srep45577
5769  Kuroda T, Yasuda S, Nakashima H, Takada N, Matsuyama S, Kusakawa S, Umezawa A, Matsuyama A, Kawamata S, Sato Y  dentification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells.  Sci Rep  2017  7(1):8163  PubMed ID: 28811571   DOI: 10.1038/s41598-017-08014-w
5770  Seta H, Matsuura K, Sekine H, Yamazaki K, Shimizu T.  Tubular Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells Generate Pulse Pressure In Vivo.  Sci Rep  2017  7:45499  PubMed ID: 28358136   DOI: 10.1038/srep45499
5771  Hayakawa K, Sakamoto Y, Kanie O, Ohtake A, Daikoku S, Ito Y, Shiota K.  Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells.  Epigenetics  2017  12(9):764-778  PubMed ID: 28762874   DOI: 10.1080/15592294.2017.1346775
5772  Sato M etal  Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment.  Oncotarget  2017  8(25):40935-40945  PubMed ID: 28402962   DOI: 10.18632/oncotarget.16783
5774  Miyagoe-Suzuki Y, Nishiyama T, Nakamura M, Narita A, Takemura F, Masuda S, Minami N, Murayama K, Komaki H, Goto YI, Takeda S.  Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status.  Stem Cells Int  2017  2017:7906843  PubMed ID: 28491099   DOI: 10.1155/2017/7906843
7048  Suzuki K, Kimura T, Shinoda H, Bai G, Daniels MJ, Arai Y, Nakano M, Nagai T.  Five colour variants of bright luminescent protein for real-time multicolour bioimaging.  Nat Commun  2016  7:13718  PubMed ID: 27966527   DOI: 10.1038/ncomms13718
7080  Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K.  Co-ordinated ocular development from human iPS cells and recovery of corneal function.  Nature  2016  531:376-80  PubMed ID: 26958835   DOI: 10.1038/nature17000
7083  Matsuura K, Seta H, Haraguchi Y, Alsayegh K, Sekine H, Shimizu T, Hagiwara N, Yamazaki K, Okano T.  TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues.  Sci Rep  2016  6:21747  PubMed ID: 26888607   DOI: 10.1038/srep21747
7315  Imaizumi K, Iha M, Nishishita N, Kawamata S, Nishikawa S, Akuta T.  A Simple and Efficient Method of Slow Freezing for Human Embryonic Stem Cells and Induced Pluripotent Stem Cells.  Methods Mol. Biol.  2016  1341:15-24  PubMed ID: 26069023   DOI: 10.1007/7651_2015_211
7326  Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K.  Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons.  Methods Mol. Biol.  2016  1357:111-31  PubMed ID: 26025620   DOI: 10.1007/7651_2015_251
9529  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Transcription Factors and Medium Suitable for Initiating the Differentiation of Human-Induced Pluripotent Stem Cells to the Hepatocyte Lineage.  J. Cell. Biochem.  2016  117:2001-9  PubMed ID: 26773721   DOI: 10.1002/jcb.25494
9535  Shoji M, Nishioka M, Minato H, Harada K, Kubo M, Fukuyama Y, Kuzuhara T.  Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells.  Biochem. Biophys. Res. Commun.  2016  470:798-803  PubMed ID: 26809091   DOI: 10.1016/j.bbrc.2016.01.092
9660  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Improved Survival and Initiation of Differentiation of Human Induced Pluripotent Stem Cells to Hepatocyte-Like Cells upon Culture in William's E Medium followed by Hepatocyte Differentiation Inducer Treatment.  PLoS ONE  2016  11:e0153435  PubMed ID: 27073925   DOI: 10.1371/journal.pone.0153435
9698  Horiguchi I, Sakai Y.  Serum replacement with albumin-associated lipids prevents excess aggregation and enhances growth of induced pluripotent stem cells in suspension culture.  Biotechnol. Prog.  2016  32:1009-16  PubMed ID: 27193385   DOI: 10.1002/btpr.2301
9756  Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H.  In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations.  Mol Brain  2016  9:70  PubMed ID: 27431206   DOI: 10.1186/s13041-016-0246-y
9794  Shimba K, Iida S, Kotani K, Jimbo Y.  Cell-cycle-dependent Ca2+ transients in human induced pluripotent stem cells revealed by a simultaneous imaging of cell nuclei and intracellular Ca2+ level.  Integr Biol (Camb)  2016  8:985-990  PubMed ID: 27713967   DOI: 10.1039/c6ib00074f
9800  Seno A, Kasai T, Ikeda M, Vaidyanath A, Masuda J, Mizutani A, Murakami H, Ishikawa T, Seno M.  Characterization of Gene Expression Patterns among Artificially Developed Cancer Stem Cells Using Spherical Self-Organizing Map.  Cancer Inform  2016  15:163-78  PubMed ID: 27559294   DOI: 10.4137/CIN.S39839
9838  Tomotsune D, Hirashima K, Fujii M, Yue F, Matsumoto K, Takizawa-Shirasawa S, Yokoyama T, Sasaki K.  Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment.  PLoS ONE  2016  11:e0162693  PubMed ID: 27632182   DOI: 10.1371/journal.pone.0162693
9853  Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H.  Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries.  Sci Rep  2016  6:33861  PubMed ID: 27653664   DOI: 10.1038/srep33861
10851  Hayashi K, Ochiai-Shino H, Shiga T, Onodera S, Saito A, Shibahara T, Azuma T.  Transplantation of human-induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects  BDJ Open  2016  2:15007  PubMed ID: 29607061   DOI: 10.1038/bdjopen.2015.7
10891    Human iPS cell derived neural cell sheets exhibit mature neural and extendable scaffold functions and promote recovery in injured mouse spinal cords  J Stem Cell Res Med  2016  1: 41-47    DOI: 10.15761/JSCRM.1000107
5758  Ashida T, Sakai S1, Taya M1.  Propagation of human iPS cells in alginate-based microcapsules prepared using reactions catalyzed by horseradish peroxidase and catalase.  Artif Cells Nanomed Biotechnol.   2016  44(6):1406-9  PubMed ID: 26148179   DOI: 10.3109/21691401.2015.1029631
5759  Takayama Y, Kida YS.  In Vitro Reconstruction of Neuronal Networks Derived from Human iPS Cells Using Microfabricated Devices.  PLoS One  2016  11(2):e0148559  PubMed ID: 26848955   DOI: 10.1371/journal.pone.0148559
13997  Matsumoto R, Shimizu K, Nagashima T, Tanaka H, Mizuno M, Kikkawa F, Hori M, Honda H.  Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells  Regen Ther  2016  5:55-63  PubMed ID: 31245502   DOI: 10.1016/j.reth.2016.07.001
14189  Ryuhei Hayashi, Ryuhei Hayashi, Yuki Ishikawa, Ryosuke Katori, Yuki Taniwaki, Motokazu Tsujikawa, Andrew J. Quantock, Kohji Nishida  Fabrication of a Corneal Epithelial Cell Sheet from Human Pluripotent Stem Cells by a Method Based on Spontaneous Ocular Cell Differentiation  Protocol Exchange  2016      DOI: 10.1038/protex.2016.009
7204  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  Involvement of the Wnt signaling pathway in feeder-free culture of human induced pluripotent stem cells.  Mol Med Rep  2015  12:6797-800  PubMed ID: 26398905   DOI: 10.3892/mmr.2015.4314
7223  Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J.  Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells.  Biomed Res Int  2015  2015:876047  PubMed ID: 26339649   DOI: 10.1155/2015/876047
7271  Fujiwara N, Shimizu J, Takai K, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.  Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells.  Exp. Neurol.  2015  271:423-31  PubMed ID: 26196079   DOI: 10.1016/j.expneurol.2015.07.008
7364  Arai Y, Yamamoto T, Minamikawa T, Takamatsu T, Nagai T.  Spectral fingerprinting of individual cells visualized by cavity-reflection-enhanced light-absorption microscopy.  PLoS ONE  2015  10:e0125733  PubMed ID: 25950513   DOI: 10.1371/journal.pone.0125733
7482  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  An Optimal Medium Supplementation Regimen for Initiation of Hepatocyte Differentiation in Human Induced Pluripotent Stem Cells.  J. Cell. Biochem.  2015  116:1479-89  PubMed ID: 25683148   DOI: 10.1002/jcb.25139
7495  Kato H, Ochiai-Shino H, Onodera S, Saito A, Shibahara T, Azuma T.  Promoting effect of 1,25(OH)2 vitamin D3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells.  Open Biol  2015  5:140201  PubMed ID: 25652541   DOI: 10.1098/rsob.140201
7521  Binata Joddar, Chieko Nishioka, Eiki Takahashi, Yoshihiro Ito  Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture.  J Mater Chem B.  2015  3:2301-2307  PubMed ID: 32262060   DOI: 10.1039/C4TB01635A
7542  M Iinuma, T Umehara, N Arimitsu, J Shimizu, H Misawa, K Takai, N Fujiwara, A Fujii, Y Ueda, S Wakisaka, T Suzuki, C Hirotsu, M Beppu, N Suzuki  Induction of neural cells with spinal motoneuron phenotype from human iPS cells and the trans-plantation to totally transected spinal cords in mice.  Inflammation and Regeneration  2015  35:154-163    DOI: 10.2492/inflammregen.35.154
7550  N Kuzumaki, M Narita  δ-Opioids and Neurogenesis.  Y. Xia (ed.), Neural Functions of the Delta-Opioid Receptor  2015  9:389-398    DOI: 10.1007/978-3-319-25495-1_9
7562  Takuya Kuroda, Satoshi Yasuda, Satoko Matsuyama a, Keiko Tano, Shinji Kusakawa, Yoshiki Sawa, Shin Kawamata, Yoji Sato  Highly sensitive droplet digital PCR method for detection of residual undifferentiated cells in cardiomyocytes derived from human pluripotent stem cells.  Regenerative Therapy  2015  2:17-23  PubMed ID: 31245455   DOI: 10.1016/j.reth.2015.08.001
5449  Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J.  Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein.  Stem Cell Reports  2015  4(5):811-20  PubMed ID: 25866158   DOI: 10.1016/j.stemcr.2015.02.016
5697  Ishikawa T, Kobayashi M, Yanagi S, Kato C, Takashima R, Kobayashi E, Hagiwara K, Ochiya T  Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors.  PLoS One  2015  10(4):e0123193  PubMed ID: 25875613   DOI: 10.1371/journal.pone.0123193
5729  Matsuura K, Kodama F, Sugiyama K, Shimizu T, Hagiwara N, Okano T.  Elimination of remaining undifferentiated induced pluripotent stem cells in the process of human cardiac cell sheet fabrication using a methionine-free culture condition.  Tissue Eng Part C Methods  2015  21(3):330-8  PubMed ID: 25245976   DOI: 10.1089/ten.TEC.2014.0198
5747  Kawamata S, Kanemura H, Sakai N, Takahashi M, Go MJ.  Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products.  J Clin Med  2015  4(1):159-71  PubMed ID: 26237025   DOI: 10.3390/jcm4010159
5749  Takenaka C, Miyajima H, Yoda Y, Imazato H, Yamamoto T, Gomi S, Ohshima Y, Kagawa K, Sasaki T, Kawamata S.  Controlled Growth and the Maintenance of Human Pluripotent Stem Cells by Cultivation with Defined Medium on Extracellular Matrix-Coated Micropatterned Dishes.  PLoS One  2015  10(6):e0129855  PubMed ID: 26115194   DOI: 10.1371/journal.pone.0129855
5751  Morita A, Soga K, Nakayama H, Ishida T, Kawanishi S, Sato EF.  Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression.  Biochem Biophys Res Commun  2015  465(3):458-63  PubMed ID: 26277393   DOI: 10.1016/j.bbrc.2015.08.039
5752  Onuma Y, Higuchi K, Aiki Y, Shu Y, Asada M, Asashima M, Suzuki M, Imamura T, Ito Y.  A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture.  PLoS One  2015  10(4):e0118931  PubMed ID: 25850016   DOI: 10.1371/journal.pone.0118931
5753  Komatsu M, Konagaya S, Egawa EY, Iwata H.  Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogel.  Biochim Biophys Acta  2015  1850(9):1669-75  PubMed ID: 25952075   DOI: 10.1016/j.bbagen.2015.04.011
5754  Cieślar-Pobuda A, Jain MV, Kratz G, Rzeszowska-Wolny J, Ghavami S, Wiechec E.  The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells.  Oncotarget  2015  6(30):29753-70  PubMed ID: 26337471   DOI: 10.18632/oncotarget.4995
5755  Konagaya S, Iwata H.  Microencapsulation of dopamine neurons derived from human induced pluripotent stem cells.  Biochim Biophys Acta  2015  1850(1):22-32  PubMed ID: 25281770   DOI: 10.1016/j.bbagen.2014.09.025
5756  Shimojima K, Okumura A, Hayashi M, Kondo T, Inoue H, Yamamoto T.  CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly.  Genomics  2015  106(4):196-203  PubMed ID: 26188257   DOI: 10.1016/j.ygeno.2015.07.001
5757  Haraguchi Y, Matsuura K, Shimizu T, Yamato M, Okano T.  Simple suspension culture system of human iPS cells maintaining their pluripotency for cardiac cell sheet engineering.  J Tissue Eng Regen Med  2015  9(12):1363-75  PubMed ID: 23728860   DOI: 10.1002/term.1761
5794  Mitsui K, Ide K, Takayama A, Wada T, Irie R, Kosai K.  Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells.  Mol Ther Methods Clin Dev  2015  2:15026  PubMed ID: 26269798   DOI: 10.1038/mtm.2015.26
5708  Daisuke Takahashi, Masato Sasaki, Kuniaki Nagamine, Keiichi Torimitsu, and Matsuhiko Nishizawa  Electroporation of Adherent Cells by Direct Lamination of Hydrogel-based Microelectrode Substrates  Chem. Lett  2014  43:444–446    DOI: 10.1246/cl.131083
5724  Ochiai-Shino H, Kato H, Sawada T, Onodera S, Saito A, Takato T, Shibahara T, Muramatsu T, Azuma T.  A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination.  PLoS One.  2014  9(6):e99534  PubMed ID: 24911063   DOI: 10.1371/journal.pone.0099534
5725  Imaizumi K, Nishishita N, Muramatsu M, Yamamoto T, Takenaka C, Kawamata S, Kobayashi K, Nishikawa S, Akuta T.  A simple and highly effective method for slow-freezing human pluripotent stem cells using dimethyl sulfoxide, hydroxyethyl starch and ethylene glycol.  PLoS One  2014  9(2):e88696  PubMed ID: 24533137   DOI: 10.1371/journal.pone.0088696
5726  Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H.  Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome.  PLoS One  2014  9(7):e102796  PubMed ID: 25050861   DOI: 10.1371/journal.pone.0102796
5727  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Sueishi M.  Dual gene expression in embryoid bodies derived from human induced pluripotent stem cells using episomal vectors.  Tissue Eng Part A  2014  20(23-24):3154-62  PubMed ID: 24980753   DOI: 10.1089/ten.TEA.2014.0132
5728  Tani H, Onuma Y, Ito Y, Torimura M.  Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells.  PLoS One  2014  9(8):e106282  PubMed ID: 25171338   DOI: 10.1371/journal.pone.0106282
5730  Bamba Y, Shofuda T, Kanematsu D, Nonaka M, Yamasaki M, Okano H, Kanemura Y.  Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics.  Biochem Biophys Res Commun  2014  447(4):683-8  PubMed ID: 24755070   DOI: 10.1016/j.bbrc.2014.04.070
5731  Tateno H, Onuma Y, Ito Y.  Live-cell imaging of human pluripotent stem cells by a novel lectin probe rBC2LCN.  Methods Mol Biol  2014  1200:313-8  PubMed ID: 25117245   DOI: 10.1007/978-1-4939-1292-6_26
5732  Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M.  Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells.  Sci Rep  2014  4:6996  PubMed ID: 25385348   DOI: 10.1038/srep06996
5733  Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, Onuma Y, Chan T, Michiue T, Furue MK, Asashima M  Enzyme-free passage of human pluripotent stem cells by controlling divalent cations.  Sci Rep  2014  4:4646  PubMed ID: 24721898   DOI: 10.1038/srep04646
5734  Tateno H, Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J.  A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells.  Sci Rep  2014  4:4069  PubMed ID: 24518842   DOI: 10.1038/srep04069
5735  Yamada R, Hattori K, Tachikawa S, Tagaya M, Sasaki T, Sugiura S, Kanamori T, Ohnuma K.  Control of adhesion of human induced pluripotent stem cells to plasma-patterned polydimethylsiloxane coated with vitronectin and γ-globulin.  J Biosci Bioeng  2014  118(3):315-22  PubMed ID: 24656306   DOI: 10.1016/j.jbiosc.2014.02.009
5736  Kowno M et al  Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria.  PLoS One  2014  9(4):e81552  PubMed ID: 24709813   DOI: 10.1371/journal.pone.0081552
5737  Ishizuka T, Goshima H, Ozawa A, Watanabe Y.  Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells.  Eur J Pharmacol  2014  740:28-34  PubMed ID: 25014757   DOI: 10.1016/j.ejphar.2014.06.056
5738  Kanemura H, Go MJ, Shikamura M, Nishishita N, Sakai N, Kamao H, Mandai M, Morinaga C, Takahashi M, Kawamata S.  Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration.  PLoS One  2014  9(1):e85336  PubMed ID: 24454843   DOI: 10.1371/journal.pone.0085336
5739  Yoshimitsu R, Hattori K, Sugiura S, Kondo Y, Yamada R, Tachikawa S, Satoh T, Kurisaki A, Ohnuma K, Asashima M, Kanamori T.  Microfluidic perfusion culture of human induced pluripotent stem cells under fully defined culture conditions.  Biotechnol Bioeng  2014  111(5):937-47  PubMed ID: 24222619   DOI: 10.1002/bit.25150
5740  Horiguchi A, Yazaki K, Aoyagi M, Ohnuki Y, Kurosawa H.  Effective Rho-associated protein kinase inhibitor treatment to dissociate human iPS cells for suspension culture to form embryoid body-like cell aggregates.  J Biosci Bioeng  2014  118(5):588-92  PubMed ID: 24856590   DOI: 10.1016/j.jbiosc.2014.04.008
5741  Tano K, Yasuda S, Kuroda T, Saito H, Umezawa A, Sato Y.  A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system.  PLoS One  2014  9(10):e110496  PubMed ID: 25347300   DOI: 10.1371/journal.pone.0110496
5742  Higuchi Y, Kawai K, Yamamoto M, Kuronuma M, Ando Y, Katano I, Nakamura M, Suemizu H.  Novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissues.  Exp Anim  2014  63(1):55-62  PubMed ID: 24521863   DOI: 10.1538/expanim.63.55
5743  Kamada M, Mitsui Y, Kumazaki T, Kawahara Y, Matsuo T, Takahashi T.  Tumorigenic risk of human induced pluripotent stem cell explants cultured on mouse SNL76/7 feeder cells.  Biochem Biophys Res Commun  2014  453(3):668-73  PubMed ID: 25305485   DOI: 10.1016/j.bbrc.2014.10.009
5744  Kuroda T, Yasuda S, Sato Y.  In vitro detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human induced pluripotent stem cells.  Methods Mol Biol  2014  1210:183-92  PubMed ID: 25173169   DOI: 10.1007/978-1-4939-1435-7_14
5745  Luo L, Kawakatsu M, Guo CW, Urata Y, Huang WJ, Ali H, Doi H, Kitajima Y, Tanaka T, Goto S, Ono Y, Xin HB, Hamano K, Li TS.  Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells.  Sci Rep  2014  4:3779  PubMed ID: 24445363   DOI: 10.1038/srep03779
5746  Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R.  Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells.  Cell Stem Cell  2014  14(1):53-67  PubMed ID: 24332837   DOI: 10.1016/j.stem.2013.11.010
5748  Tsugata T1, Nikoh N, Kin T, Saitoh I, Noguchi Y, Ueki H, Watanabe M, James Shapiro AM, Noguchi H.  Potential Factors for the Differentiation of ESCs/iPSCs Into Insulin-Producing Cells.  Cell Med  2014  7(2):83-93  PubMed ID: 26858897   DOI: 10.3727/215517914X685178
13757  Ishihara Y, Tsuno S, Kuwamoto S, Yamashita T, Endo Y, Hasegawa J, Miura N.  Hsa-miR-520d converts fibroblasts into CD105+ populations  Drugs R D  2014  14(4):253-64.  PubMed ID: 25303886   DOI: 10.1007/s40268-014-0064-6
15918  Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS.  Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease  J Exp Med  2014  211(8):1551-70  PubMed ID: 25049335   DOI: 10.1084/jem.20132451
16004  Ryotaro Yamada, Koji Hattori, Motohiro Tagaya, Toru Sasaki, Daisuke Miyamoto, Kohji Nakazawa, Shinji Sugiura, Toshiyuki Kanamori, Kiyoshi Ohnuma  Plasma-Patterned Polydimethylsiloxane Surface With Single-Step Coating with a Mixture of Vitronectin and Albumin Enables the Formation of Small Discs and Spheroids of Human Induced Pluripotent Stem Cells  Plasma Medicine  2014  4:165-176    DOI: 10.1615/plasmamed.2014012077
5707  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Activin A is essential for Feeder-free culture of human induced pluripotent stem cells.  J Cell Biochem  2013  114(3):584-8  PubMed ID: 22991093   DOI: 10.1002/jcb.24395
5709  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Survival of primary human hepatocytes and death of induced pluripotent stem cells in media lacking glucose and arginine.  PLoS One  2013  8(8):e71897  PubMed ID: 23967260   DOI: 10.1371/journal.pone.0071897
5710  Fujiwara N, Shimizu J, Takai K, Arimitsu N, Saito A, Kono T, Umehara T, Ueda Y, Wakisaka S, Suzuki T, Suzuki N.  Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells.  Neurosci Lett  2013  557 Pt B:129-34  PubMed ID: 24466594  
5711  Saito A, Ochiai H, Okada S, Miyata N, Azuma T.  Suppression of Lefty expression in induced pluripotent cancer cells.  FASEB J  2013  27(6):2165-74  PubMed ID: 23407711   DOI: 10.1096/fj.12-221432
5712  Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y.  Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells.  PLoS One  2013  8(1):e55226  PubMed ID: 23383118   DOI: 10.1371/journal.pone.0055226
5713  Shofuda T, Fukusumi H, Kanematsu D, Yamamoto A, Yamasaki M, Arita N, Kanemura Y.  A method for efficiently generating neurospheres from human-induced pluripotent stem cells using microsphere arrays.  Neuroreport  2013  24(2):84-90  PubMed ID: 23238165   DOI: 10.1097/WNR.0b013e32835cb677
5714  Onuma Y, Tateno H, Hirabayashi J, Ito Y, Asashima M.  rBC2LCN, a new probe for live cell imaging of human pluripotent stem cells.  Biochem Biophys Res Commun  2013  431(3):524-9  PubMed ID: 23321312   DOI: 10.1016/j.bbrc.2013.01.025
5715  Horii T, Tamura D, Morita S, Kimura M, Hatada I.  Generation of an ICF syndrome model by efficient genome editing of human induced pluripotent stem cells using the CRISPR system.  Int J Mol Sci  2013  14(10):19774-8  PubMed ID: 24084724   DOI: 10.3390/ijms141019774
5716  Donai K, Kuroda K, Guo Y, So KH, Sone H, Kobayashi M, Nishimori K, Fukuda T.  Establishment of a reporter system to monitor silencing status in induced pluripotent stem cell lines.  Anal Biochem  2013  443(1):104-12  PubMed ID: 23973628   DOI: 10.1016/j.ab.2013.08.014
5717  Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S.  A human Dravet syndrome model from patient induced pluripotent stem cells.  Mol Brain  2013  6:19  PubMed ID: 23639079   DOI: 10.1186/1756-6606-6-19
5718  Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J.  Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN.  Stem Cells Transl Med  2013  2(4):265-73  PubMed ID: 23526252   DOI: 10.5966/sctm.2012-0154
5719  Toshiaki Ishizuka Hazuki Goshima Ayako Ozawa Yasuhiro Watanabe  Stimulation ofα1-adrenoceptor or angiotensin type 1 receptorenhances DNA synthesis in human-induced pluripotent stemcells via Gq-coupled receptor-dependent signaling pathways  European Journal of Pharmacology  2013  714:202-209  PubMed ID: 23792040   DOI: 10.1016/j.ejphar.2013.06.003
5720  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Single-step protocol for the differentiation of human-induced pluripotent stem cells into hepatic progenitor-like cells.  Biomed Rep  2013  1(1):18-22.  PubMed ID: 24648886   DOI: 10.3892/br.2012.2
5722  Guo CW, Kawakatsu M, Idemitsu M, Urata Y, Goto S, Ono Y, Hamano K, Li TS.  Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells.  J Cell Physiol  2013  228(11):2159-66  PubMed ID: 23589166   DOI: 10.1002/jcp.24389
5723  Inagaki E, Hatou S, Yoshida S, Miyashita H, Tsubota K, Shimmura S.  Expression and distribution of claudin subtypes in human corneal endothelium.  Invest Ophthalmol Vis Sci  2013  54(12):7258-65  PubMed ID: 24114540   DOI: 10.1167/iovs.13-12022
13655  Ohta S, Imaizumi Y, Akamatsu W, Okano H, Kawakami Y.  Generation of human melanocytes from induced pluripotent stem cells  Methods Mol Biol  2013  989:193-215  PubMed ID: 23483397   DOI: 10.1007/978-1-62703-330-5_16
5702  Hayashi R, Ishikawa Y, Ito M, Kageyama T, Takashiba K, Fujioka T, Tsujikawa M, Miyoshi H, Yamato M, Nakamura Y, Nishida K.  Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium.  PLoS One  2012  7(9):e45435  PubMed ID: 23029008   DOI: 10.1371/journal.pone.0045435
5703  Hasehira K, Tateno H, Onuma Y, Ito Y, Asashima M, Hirabayashi J.  Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells.  Mol Cell Proteomics  2012  11(12):1913-23  PubMed ID: 23023295   DOI: 10.1074/mcp.M112.020586
5704  Kuroda T, Yasuda S, Kusakawa S, Hirata N, Kanda Y, Suzuki K, Takahashi M, Nishikawa S, Kawamata S, Sato Y.  Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells.  PLoS One  2012  7(5):e37342  PubMed ID: 22615985   DOI: 10.1371/journal.pone.0037342
5706  Otsuji TG, Kurose Y, Suemori H, Tada M, Nakatsuji N.  Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.  PLoS One  2012  7(9):e45010  PubMed ID: 22984602   DOI: 10.1371/journal.pone.0045010
5721  Shofuda T, Kanematsu D, Fukusumi H, Yamamoto A, Bamba Y, Yoshitatsu S, Suemizu H, Nakamura M, Sugimoto Y, Furue MK, Kohara A, Akamatsu W, Okada Y, Okano H, Yamasaki M, Kanemura Y.  Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells.  Cell Med  2012  4(3):125-47  PubMed ID: 26858858   DOI: 10.3727/215517912X658918
7771  Ogawa S, Tokumoto Y, Miyake J, Nagamune T.  Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells.  In Vitro Cell. Dev. Biol. Anim.  2011  47:464-9  PubMed ID: 21695581   DOI: 10.1007/s11626-011-9435-2
5698  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Activin A maintains pluripotency markers and proliferative potential of human induced pluripotent stem cells.  Exp Ther Med  2011  2(3):405-408  PubMed ID: 22977517   DOI: 10.3892/etm.2011.219
5750  Kumazaki T, Kurata S, Matsuo T, Mitsui Y, Takahashi T.  Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1.  Hum Cell  2011  24(2):96-103  PubMed ID: 21562774   DOI: 10.1007/s13577-011-0016-1
5699  Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A.  A distinct role for Pin1 in the induction and maintenance of pluripotency.  J Biol Chem  2011  286(13):11593-603  PubMed ID: 21296877   DOI: 10.1074/jbc.M110.187989
5700  Yoshizaki S, Nishi M, Kondo A, Kojima Y, Yamamoto N, Ryo A.  Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160.  Front Microbiol  2011  2:27  PubMed ID: 21687419   DOI: 10.3389/fmicb.2011.00004



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