CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [HPS0063 : 201B7]

20937 Tsujimoto H, Katagiri N, Ijiri Y, Sasaki B, Kobayashi Y, Mima A, Ryosaka M, Furuyama K, Kawaguchi Y, Osafune K. In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells. PLoS One 2022 17(11)6:e0275600 PubMed ID: 36378656 DOI: 10.1371/journal.pone.0275600

3675 Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007 131(5):861-72 PubMed ID: 18035408 DOI: 10.1016/j.cell.2007.11.019

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21544 Ueki M, Suzuki T, Kato Y. Large-scale cultivation of human iPS cells in bioreactor with reciprocal mixing. J Biosci Bioeng 2024 PubMed ID: 38185598 DOI: 10.1016/j.jbiosc.2023.12.008

21546 Kuroda T, Yasuda S, Matsuyama S, Miura T, Sawada R, Matsuyama A, Yamamoto Y, Morioka MS, Kawaji H, Kasukawa T, Itoh M, Akutsu H, Kawai J, Sato Y. ROR2 expression predicts human induced pluripotent stem cell differentiation into neural stem/progenitor cells and GABAergic neurons. Sci Rep 2024 14(1):690 PubMed ID: 38184695 DOI: 10.1038/s41598-023-51082-4

21552 Kurabi A, Dewan K, Kerschner JE, Leichtle A, Li JD, Santa Maria PL, Preciado D. PANEL 3: Otitis media animal models, cell culture, tissue regeneration & pathophysiology. Int J Pediatr Otorhinolaryngol 2024 176:111814 PubMed ID: 38101097 DOI: 10.1016/j.ijporl.2023.111814

21572 Shaji M, Tamada A, Fujimoto K, Muguruma K, Karsten SL, Yokokawa R. Deciphering potential vascularization factors of on-chip co-cultured hiPSC-derived cerebral organoids. Lab Chip 2024 PubMed ID: 38284292 DOI: 10.1039/d3lc00930k

21601 Kitano M, Hayashi Y, Ohnishi H, Okuyama H, Yoshimatsu M, Mizuno K, Kuwata F, Tada T, Kishimoto Y, Morita S, Omori K. Changes in the Proportion of Each Cell Type After hiPSC-Derived Airway Epithelia Transplantation. Cell Transplant 2024 33:9636897241228026 PubMed ID: 38372247 DOI: 10.1177/09636897241228026

21622 Shiraishi T, Bono K, Hiraki H, Manome Y, Oka H, Iguchi Y, Okano HJ. The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease. Cell Mol Life Sci 2024 81(1):103 PubMed ID: 38409392 DOI: 10.1007/s00018-024-05123-4

21668 Homma H, Yoshioka Y, Fujita K, Shirai S, Hama Y, Komano H, Saito Y, Yabe I, Okano H, Sasaki H, Tanaka H, Okazawa H. Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Commun Biol 2024 7(1):413 PubMed ID: 38594382 DOI: 10.1038/s42003-024-06066-z

21767 Intoh A, Watanabe-Susaki K, Kato T, Kiritani H, Kurisaki A. EPHA2 is a novel cell surface marker of OCT4-positive undifferentiated cells during the differentiation of mouse and human pluripotent stem cells. Stem Cells Transl Med 2024 PubMed ID: 38811016 DOI: 10.1093/stcltm/szae036

21816 Sekine M, Fujiwara M, Okamoto K, Ichida K, Nagata K, Hille R, Nishino T. Significance and Amplification Methods of the Purine Salvage Pathway in Human Brain Cells. J Biol Chem 2024 PubMed ID: 38960035 DOI: 10.1016/j.jbc.2024.107524

21909 Yasuda S, Bando K, Henry MP, Libertini S, Watanabe T, Bando H, Chen C, Fujimori K, Harada K, Kuroda T, Lemmens M, Marginean D, Moss D, Pereira Mouriès L, Nicholas NS, Smart MJK, Terai O, Sato Y. Detection of residual pluripotent stem cells in cell therapy products utilizing droplet digital PCR: an international multisite evaluation study. Stem Cells Transl Med 2024 PubMed ID: 39120125 DOI: 10.1093/stcltm/szae058

21988 Saegusa C, Mutai H, Saeki T, Matsuzaki S, Mizukoshi A, Kitajiri SI, Matsunaga T, Hosoya M, Okano H, Fujioka M. Generation of four induced pluripotent stem cell lines (KEIUi004-A, KEIUi005-A, KEIUi006-A, and KEIUi007-A) from patients with sensorineural hearing loss with mutation in EYA4 gene Stem Cell Res 2024 79:103489 PubMed ID: 39002249 DOI: 10.1016/j.scr.2024.103489

21990 Maruyama K, Miyazaki S, Kobayashi R, Hikita H, Tsubone T, Ohnuma K. The migration pattern of cells during the mesoderm and endoderm differentiation from human pluripotent stem cells In Vitro Cell Dev Biol Anim 2024 60(5):535-543 PubMed ID: 38656570 DOI: 10.1007/s11626-024-00904-4

22007 Masano Y, Saegusa C, Ishikawa M, Matsunaga T, Okano H, Fujioka M. Generation of an induced pluripotent stem cell line (KEIUi008-A) from a hearing loss patient with an A1555G mutation in mitochondrial DNA. Stem Cell Res 2024 78:103452 PubMed ID: 38815527 DOI: 10.1016/j.scr.2024.103452

22011 Watanabe T, Yasuda S, Kusakawa S, Kuroda T, Furukawa H, Futamura M, Shimizu S, Morishita A, Hata S, Koeda A, Komatsu K, Sato Y. Multisite studies for optimization of a highly efficient culture assay used for in vitro detection of residual undifferentiated human pluripotent stem cells intermingled in cell therapy products. Regen Ther 2024 26:315-323 PubMed ID: 38983832 DOI: 10.1016/j.reth.2024.06.007

22138 Howard L, Ishikawa Y, Katayama T, Park SJ, Hill MJ, Blake DJ, Nishida K, Hayashi R, Quantock AJ. Single-cell transcriptomics reveals the molecular basis of human iPS cell differentiation into ectodermal ocular lineages. Commun Biol 2024 7(1):1495 PubMed ID: 39532995 DOI: 10.1038/s42003-024-07130-4

22140 Horikawa A, Michiue T. Controlling spheroid attachment improves pancreatic beta cell differentiation from human iPS cells. In Vitro Cell Dev Biol Anim 2024 PubMed ID: 39546193 DOI: 10.1007/s11626-024-00991-3

22171 Matsuo-Takasaki M, Kambayashi S, Hemmi Y, Wakabayashi T, Shimizu T, An Y, Ito H, Takeuchi K, Ibuki M, Kawashima T, Masayasu R, Suzuki M, Kawai Y, Umekage M, Kato TM, Noguchi M, Nakade K, Nakamura Y, Nakaishi T, Nishishita N, Tsukahara M, Hayashi Y. Complete suspension culture of human induced pluripotent stem cells supplemented with suppressors of spontaneous differentiation. Elife 2024 12 PubMed ID: 39529479 DOI: 10.7554/eLife.89724

22196 Kikuchi T, Matsuura K, Shimizu T. Low-adhesion culture selection for human iPS cell-derived cardiomyocytes Sci Rep 2024 14(1):11081 PubMed ID: 38744867 DOI: 10.1038/s41598-024-60765-5

22314 Nuermaimaiti M, Ishikawa KI, Oyama G, Nonaka R, Shiga T, Jo T, Tsunemi T, Nakamura R, Krüger R, Akamatsu W, Hattori N. Human induced pluripotent stem cell-derived dopaminergic neurons release alpha-synuclein through neuronal activity. Neurosci Res 2024 PubMed ID: 39617169 DOI: 10.1016/j.neures.2024.11.007

19655 Mu A, Hira A, Mori M, Okamoto Y, Takata M. Fanconi anemia and Aldehyde Degradation Deficiency Syndrome: Metabolism and DNA repair protect the genome and hematopoiesis from endogenous DNA damage DNA Repair (Amst) 2023 130:103546 PubMed ID: 37572579 DOI: 10.1016/j.dnarep.2023.103546

19705 Soo-jeong Park, Jeong-Woo Choi Nanoscale Diesel-Exhaust Particulate Matter (DPM) Impairs Synaptic Plasticity of Human iPSCs-Derived Cerebral Organoids BioChip Journal 2023 17:BioChip Journal DOI: 10.1007/s13206-023-00107-1

19717 Akaba Y, Takahashi S, Suzuki K, Kosaki K, Tsujimura K. miR-514a promotes neuronal development in human iPSC-derived neurons Front Cell Dev Biol 2023 11:1096463 PubMed ID: 36824367 DOI: 10.3389/fcell.2023.1096463

19750 Kitao M, Hayashi R, Nomi K, Kobayashi R, Katayama T, Takayanagi H, Oguchi A, Murakawa Y, Nishida K. Identification of BST2 as a conjunctival epithelial stem/progenitor cell marker iScience 2023 26(7):107016 PubMed ID: 37389178 DOI: 10.1016/j.isci.2023.107016

19819 Zhang D, Eguchi N, Okazaki S, Sora I, Hishimoto A. Telencephalon Organoids Derived from an Individual with ADHD Show Altered Neurodevelopment of Early Cortical Layer Structure Stem Cell Rev Rep 2023 19(5):1482-1491 PubMed ID: 36872412 DOI: 10.1007/s12015-023-10519-z

19841 Yoshioka Y, Taniguchi JB, Homma H, Tamura T, Fujita K, Inotsume M, Tagawa K, Misawa K, Matsumoto N, Nakagawa M, Inoue H, Tanaka H, Okazawa H. AAV-mediated editing of PMP22 rescues Charcot-Marie-Tooth disease type 1A features in patient-derived iPS Schwann cells Commun Med (Lond) 2023 3(1):170 PubMed ID: 38017287 DOI: 10.1038/s43856-023-00400-y

19859 Lázaro J, Costanzo M, Sanaki-Matsumiya M, Girardot C, Hayashi M, Hayashi K, Diecke S, Hildebrandt TB, Lazzari G, Wu J, Petkov S, Behr R, Trivedi V, Matsuda M, Ebisuya M. A stem cell zoo uncovers intracellular scaling of developmental tempo across mammals Cell Stem Cell 2023 30(7):938-949 PubMed ID: 37343565 DOI: 10.1016/j.stem.2023.05.014

19862 Takayama Y, Akagi Y, Kida YS. Deciphering the Molecular Mechanisms of Autonomic Nervous System Neuron Induction through Integrative Bioinformatics Analysis Int J Mol Sci 2023 24(10):9053 PubMed ID: 37240399 DOI: 10.3390/ijms24109053

19938 Liu L, Yang J, Otani Y, Shiga T, Yamaguchi A, Oda Y, Hattori M, Goto T, Ishibashi S, Kawashima-Sonoyama Y, Ishihara T, Matsuzaki Y, Akamatsu W, Fujitani M, Taketani T. MELAS-Derived Neurons Functionally Improve by Mitochondrial Transfer from Highly Purified Mesenchymal Stem Cells (REC) Int J Mol Sci 2023 24(24):17186 PubMed ID: 38139018 DOI: 10.3390/ijms242417186

20931 Shoji M, Kuzuhara T. Imaging Analysis of Neurotrophic Effects by CCN2 Protein in Neuronal Precursor Cells Derived from Human-Induced Pluripotent Stem Cells. Methods Mol Biol 2023 2582:269-280 PubMed ID: 36370356 DOI: 10.1007/978-1-0716-2744-0_18

21010 Shimada M, Tokumiya T, Miyake T, Tsukada K, Kanzaki N, Yanagihara H, Kobayashi J, Matsumoto Y. Implication of E3 ligase RAD18 in UV-induced mutagenesis in human induced pluripotent stem cells and neuronal progenitor cells. J Radiat Res 2023 PubMed ID: 36634340 DOI: 10.1093/jrr/rrac099

21070 Tanaka Y, Furuhata E, Maeda S, Kishima M, Suzuki H, Suzuki T. A dataset of definitive endoderm and hepatocyte differentiations from human induced pluripotent stem cells. Sci Data 2023 10(1):93 PubMed ID: 36788249 DOI: 10.1038/s41597-023-02001-9

21160 Yue F, Era T, Yamaguchi T, Kosho T. Pathophysiological Investigation of Skeletal Deformities of Musculocontractural Ehlers-Danlos Syndrome Using Induced Pluripotent Stem Cells. Genes (Basel) 2023 14(3) PubMed ID: 36981001 DOI: 10.3390/genes14030730

21189 Matsumoto N, Yamanaka S, Morimoto K, Matsui K, Nishimura S, Kinoshita Y, Inage Y, Fujimori K, Kuroda T, Saito Y, Takamura T, Fujimoto T, Tajiri S, Matsumoto K, Inoue M, Kobayashi E, Yokoo T. Evaluation of the ability of human induced nephron progenitor cells to form chimeric renal organoids using mouse embryonic renal progenitor cells. Biochem Biophys Res Commun 2023 662:18-25 PubMed ID: 37094429 DOI: 10.1016/j.bbrc.2023.04.052

21192 Otsuka S, Qin XY, Wang W, Ito T, Nansai H, Abe K, Fujibuchi W, Nakao Y, Sone H. iGEM as a human iPS cell-based global epigenetic modulation detection assay provides throughput characterization of chemicals affecting DNA methylation. Sci Rep 2023 13(1):6663 PubMed ID: 37095195 DOI: 10.1038/s41598-023-33729-4

21260 Taga S, Suga H, Nakano T, Kuwahara A, Inoshita N, Kodani Y, Nagasaki H, Sato Y, Tsumura Y, Sakakibara M, Soen M, Miwata T, Ozaki H, Kano M, Watari K, Ikeda A, Yamanaka M, Takahashi Y, Kitamoto S, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Yasuda Y, Hagiwara D, Iwama S, Tomigahara Y, Kimura T, Arima H. Generation and purification of ACTH-secreting hPSC-derived pituitary cells for effective transplantation. Stem Cell Reports 2023 PubMed ID: 37295423 DOI: 10.1016/j.stemcr.2023.05.002

21311 Kaneko H, Kaitsuka T, Tomizawa K. Artificial induction of circadian rhythm by combining exogenous BMAL1 expression and polycomb repressive complex 2 inhibition in human induced pluripotent stem cells. Cell Mol Life Sci 2023 80(8):200 PubMed ID: 37421441 DOI: 10.1007/s00018-023-04847-z

21342 Oiwa K, Watanabe S, Onodera K, Iguchi Y, Kinoshita Y, Komine O, Sobue A, Okada Y, Katsuno M, Yamanaka K. Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis. Sci Adv 2023 9(31):eadf6895 PubMed ID: 37540751 DOI: 10.1126/sciadv.adf6895

21348 Katsura M, Urade Y, Nansai H, Kobayashi M, Taguchi A, Ishikawa Y, Ito T, Fukunaga H, Tozawa H, Chikaoka Y, Nakaki R, Echigo A, Kohro T, Sone H, Wada Y. Low-dose radiation induces unstable gene expression in developing human iPSC-derived retinal ganglion organoids. Sci Rep 2023 13(1):12888 PubMed ID: 37558727 DOI: 10.1038/s41598-023-40051-6

21395 Tanaka Y, Kadota S, Zhao J, Kobayashi H, Okano S, Izumi M, Honda Y, Ichimura H, Shiba N, Uemura T, Wada Y, Chuma S, Nakada T, Tohyama S, Fukuda K, Yamada M, Seto T, Kuwahara K, Shiba Y. Mature human induced pluripotent stem cell-derived cardiomyocytes promote angiogenesis through alpha-B crystallin. Stem Cell Res Ther 2023 14(1):240 PubMed ID: 37679796 DOI: 10.1186/s13287-023-03468-4

21405 Murata H, Phoo MTZ, Ochi T, Tomonobu N, Yamamoto KI, Kinoshita R, Miyazaki I, Nishibori M, Asanuma M, Sakaguchi M. Phosphorylated SARM1 is involved in the pathological process of rotenone-induced neurodegeneration. J Biochem 2023 PubMed ID: 37725528 DOI: 10.1093/jb/mvad068

21439 Terada E, Bamba Y, Takagaki M, Kawabata S, Tachi T, Nakamura H, Nishida T, Kishima H. Silicate Microfiber Scaffolds Support the Formation and Expansion of the Cortical Neuronal Layer of Cerebral Organoids With a Sheet-Like Configuration. Stem Cells Transl Med 2023 PubMed ID: 37843388 DOI: 10.1093/stcltm/szad066

21488 Akagi Y, Takayama Y, Nihashi Y, Yamashita A, Yoshida R, Miyamoto Y, Kida YS. Functional engineering of human iPSC-derived parasympathetic neurons enhances responsiveness to gastrointestinal hormones. FEBS Open Bio 2023 PubMed ID: 38013211 DOI: 10.1002/2211-5463.13741

21532 Tomizawa M, Shinozaki F, Mikata T, Tanno H, Shigeta M. Lactate promotes survival and hepatocyte differentiation of human induced pluripotent stem cells in a medium without glucose and supplemented with galactose. Biomed Rep 2023 19(6):90 PubMed ID: 37901872 DOI: 10.3892/br.2023.1672

21924 Murata H, Yasui Y, Oiso K, Ochi T, Tomonobu N, Yamamoto KI, Kinoshita R, Sakaguchi M. STAT1/3 signaling suppresses axon degeneration and neuronal cell death through regulation of NAD+-biosynthetic and consuming enzymes Cell Signal 2023 108:110717. PubMed ID: 37187216 DOI: 10.1016/j.cellsig.2023.110717

22199 Nakamura R, Nonaka R, Oyama G, Jo T, Kamo H, Nuermaimaiti M, Akamatsu W, Ishikawa KI, Hattori N. A defined method for differentiating human iPSCs into midbrain dopaminergic progenitors that safely restore motor deficits in Parkinson's disease Front Neurosci 2023 17:1202027 PubMed ID: 37502682 DOI: 10.3389/fnins.2023.1202027

22202 Uno N, Satofuka H, Miyamoto H, Honma K, Suzuki T, Yamazaki K, Ito R, Moriwaki T, Hamamichi S, Tomizuka K, Oshimura M, Kazuki Y. Treatment of CHO cells with Taxol and reversine improves micronucleation and microcell-mediated chromosome transfer efficiency Mol Ther Nucleic Acids 2023 33:391-403 PubMed ID: 37547291 DOI: 10.1016/j.omtn.2023.07.002

22203 Quantitative Proteomics for the Development and Manufacturing of Human-Induced Pluripotent Stem Cell-Derived Neural Stem Cells Using Data-Independent Acquisition Mass Spectrometry Quantitative Proteomics for the Development and Manufacturing of Human-Induced Pluripotent Stem Cell-Derived Neural Stem Cells Using Data-Independent Acquisition Mass Spectrometry J Proteome Res 2023 22(6):1843-1854 PubMed ID: 37097202 DOI: 10.1021/acs.jproteome.2c00841

17534 Miyake N, Nagai T, Suga H, Osuka S, Kasai T, Sakakibara M, Soen M, Ozaki H, Miwata T, Asano T, Kano M, Muraoka A, Nakanishi N, Nakamura T, Goto M, Yasuda Y, Kawaguchi Y, Miyata T, Kobayashi T, Sugiyama M, Onoue T, Hagiwara D, Iwama S, Iwase A, Inoshita N, Arima H, Kajiyama H. Functional Lactotrophs in Induced Adenohypophysis Differentiated From Human iPS Cells Endocrinology 2022 163(3):bqac004 PubMed ID: 35085394 DOI: 10.1210/endocr/bqac004

17538 Kodani Y, Kawata M, Suga H, Kasai T, Ozone C, Sakakibara M, Kuwahara A, Taga S, Arima H, Kameyama T, Saito K, Nakashima A, Nagasaki H. EpCAM Is a Surface Marker for Enriching Anterior Pituitary Cells From Human Hypothalamic-Pituitary Organoids Front Endocrinol (Lausanne) 2022 13:941166 PubMed ID: 35903276 DOI: 10.3389/fendo.2022.941166

19243 Shimizu K, Kassai H, Kamei Y, Yamamoto K, Nagashima T, Maekawa T, Akiyama H, Honda H. Alignment of Skeletal Muscle Cells Facilitates Acetylcholine Receptor Clustering and Neuromuscular Junction Formation with Co-Cultured Human iPSC-Derived Motor Neurons Cells 2022 11(23):3760 PubMed ID: 36497020 DOI: 10.3390/cells11233760

20537 Nakatani E, Okajima R, Ohnuma K. Slow diffusion on the monolayer culture enhances auto/paracrine effects of Noggin in differentiation of human iPS cells induced by BMP. Biochem Biophys Rep 2022 29:101195 PubMed ID: 35005256 DOI: 10.1016/j.bbrep.2021.101195

20566 Kanno S, Okubo Y, Kageyama T, Yan L, Kitajima S, Fukuda J. Establishment of a developmental toxicity assay based on human iPSC reporter to detect FGF signal disruption. iScience 2022 25(2):103770 PubMed ID: 35146387 DOI: 10.1016/j.isci.2022.103770

20530 Kanno S, Okubo Y, Kageyama T, Yan L, Fukuda J. Integrated fibroblast growth factor signal disruptions in human iPS cells for prediction of teratogenic toxicity of chemicals. J Biosci Bioeng 2022 PubMed ID: 35034848 DOI: 10.1016/j.jbiosc.2021.12.006

20579 Uno N, Takata S, Komoto S, Miyamoto H, Nakayama Y, Osaki M, Mayuzumi R, Miyazaki N, Hando C, Abe S, Sakuma T, Yamamoto T, Suzuki T, Nakajima Y, Oshimura M, Tomizuka K, Kazuki Y. Panel of human cell lines with human/mouse artificial chromosomes. Sci Rep 2022 12(1):3009 PubMed ID: 35194085 DOI: 10.1038/s41598-022-06814-3

16355 Takeshi Tada, Hiroe Ohnishi, Norio Yamamoto, Fumihiko Kuwata, Yasuyuki Hayashi, Hideaki Okuyama, Tsunetaro Morino, Yoshiyuki Kasai, Hiromi Kojima, Koichi Omori Transplantation of a human induced pluripotent stem cell-derived airway epithelial cell sheet into the middle ear of rats Regen Ther 2022 19:77-87 PubMed ID: 35097166 DOI: 10.1016/j.reth.2022.01.001

16361 Takahashi H, Oikawa F, Takeda N, Shimizu T. Contraction Control of Aligned Myofiber Sheet Tissue by Parallel Oriented iPS Cell-derived Neurons Tissue Eng Part A 2022 Jan 21 PubMed ID: 35057641 DOI: 10.1089/ten.TEA.2021.0202

20587 Uehara K, Koyanagi-Aoi M, Koide T, Itoh T, Aoi T. Epithelial-derived factors induce muscularis mucosa of human induced pluripotent stem cell-derived gastric organoids. Stem Cell Reports 2022 PubMed ID: 35245440 DOI: 10.1016/j.stemcr.2022.02.002

16439 Otsuka Y, Imamura K, Oishi A, Kondo T, Suga M, Yada Y, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Tsujikawa A, Inoue H. One-step induction of photoreceptor-like cells from human iPSCs by delivering transcription factors iScience 2022 25(4):103987. PubMed ID: 35330684 DOI: 10.1016/j.isci.2022.103987

20662 Hayashi R, Okubo T, Kudo Y, Ishikawa Y, Imaizumi T, Suzuki K, Shibata S, Katayama T, Park SJ, Young RD, Quantock AJ, Nishida K. Generation of 3D lacrimal gland organoids from human pluripotent stem cells. Nature 2022 PubMed ID: 35444274 DOI: 10.1038/s41586-022-04613-4

20683 Sanaki-Matsumiya M, Matsuda M, Gritti N, Nakaki F, Sharpe J, Trivedi V, Ebisuya M. Periodic formation of epithelial somites from human pluripotent stem cells. Nat Commun 2022 13(1):2325 PubMed ID: 35484123 DOI: 10.1038/s41467-022-29967-1

16448 Suzuki T, Furuhata E, Maeda S, Kishima M, Miyajima Y, Tanaka Y, Lim J, Nishimura H, Nakanishi Y, Shojima A, Suzuki H. GATA6 is predicted to regulate DNA methylation in an in vitro model of human hepatocyte differentiation Commun Biol 2022 ;5(1):414 PubMed ID: 35508708 DOI: 10.1038/s42003-022-03365-1

20670 Saito Y, Yamanaka S, Matsumoto N, Takamura T, Fujimoto T, Matsui K, Tajiri S, Matsumoto K, Kobayashi E, Yokoo T. Generation of functional chimeric kidney containing exogenous progenitor-derived stroma and nephron via a conditional empty niche. Cell Rep 2022 39(11):110933 PubMed ID: 35705028 DOI: 10.1016/j.celrep.2022.110933

16780 Miura K, Matsuura K, Yamasaki Itoyama Y, Sasaki D, Takada T, Furutani Y, Hayama E, Ito M, Nomura S, Morita H, Toyoda M, Umezawa A, Onoue K, Saito Y, Aburatani H, Nakanishi T, Hagiwara N, Komuro I, Shimizu T. Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy Int Heart J 2022 63(2):338-346 PubMed ID: 35354754 DOI: 10.1536/ihj.21-790

20780 Sim EZ, Enomoto T, Shiraki N, Furuta N, Kashio S, Kambe T, Tsuyama T, Arakawa A, Ozawa H, Yokoyama M, Miura M, Kume S. Methionine metabolism regulates pluripotent stem cell pluripotency and differentiation through zinc mobilization. Cell Rep 2022 40(3):111120 PubMed ID: 35858556 DOI: 10.1016/j.celrep.2022.111120

16836 Koide T, Koyanagi-Aoi M, Uehara K, Kakeji Y, Aoi T. CDX2-induced intestinal metaplasia in human gastric organoids derived from induced pluripotent stem cells iScience 2022 25(5):104314 PubMed ID: 35602937 DOI: 10.1016/j.isci.2022.104314

16845 Morimoto Y, Tokumitsu A, Sone T, Hirota Y, Tamura R, Sakamoto A, Nakajima K, Toda M, Kawakami Y, Okano H, Ohta S. TPT1 Supports Proliferation of Neural Stem/Progenitor Cells and Brain Tumor Initiating Cells Regulated by Macrophage Migration Inhibitory Factor (MIF) Neurochem Res 2022 May 27 PubMed ID: 35622214 DOI: 10.1007/s11064-022-03629-6

20795 Kanno S, Mizota K, Okubo Y, Kageyama T, Yan L, Fukuda J. Luciferase assay system to monitor fibroblast growth factor signal disruption in human iPSCs. STAR Protoc 2022 PubMed ID: 35677614 DOI: 10.1016/j.xpro.2022.101439

20850 Tanaka H, Tsuji D, Watanabe R, Ohnishi Y, Kitaguchi S, Nakae R, Teramoto H, Tsukimoto J, Horii Y, Itoh K. Aberrant autophagy in lysosomal storage disorders marked by a lysosomal SNARE protein shortage due to suppression of endocytosis. J Inherit Metab Dis 2022 PubMed ID: 36102069 DOI: 10.1002/jimd.12558

20865 Nakashima Y, Miyagi-Shiohira C, Saitoh I, Watanabe M, Matsushita M, Tsukahara M, Noguchi H. Induced hepatic stem cells are suitable for human hepatocyte production. iScience 2022 25(10):105052 PubMed ID: 36147945 DOI: 10.1016/j.isci.2022.105052

17191 Yamamoto T, Arita M, Kuroda H, Suzuki T, Kawamata S. Improving the differentiation potential of pluripotent stem cells by optimizing culture conditions Sci Rep 2022 12(1):14147 PubMed ID: 35986054 DOI: 10.1038/s41598-022-18400-8

20936 Yoshida S, Kato TM, Sato Y, Umekage M, Ichisaka T, Tsukahara M, Takasu N, Yamanaka S. A clinical-grade HLA haplobank of human induced pluripotent stem cells matching approximately 40% of the Japanese population. Med (N Y) 2022 PubMed ID: 36395757 DOI: 10.1016/j.medj.2022.10.003

20987 Limjanthong N, Tohbaru Y, Okamoto T, Okajima R, Kusama Y, Kojima H, Fujimura A, Miyazaki T, Kanamori T, Sugiura S, Ohnuma K. Gravity-driven microfluidic device placed on a slow-tilting table enables constant unidirectional perfusion culture of human induced pluripotent stem cells. J Biosci Bioeng 2022 PubMed ID: 36586792 DOI: 10.1016/j.jbiosc.2022.11.007

17433 Sugiura R, Hamano S, Tomokiyo A, Hasegawa D, Yoshida S, Sugii H, Fujino S, Adachi O, Kadowaki M, Yamashita D, Maeda H. PAX9 Is Involved in Periodontal Ligament Stem Cell-like Differentiation of Human-Induced Pluripotent Stem Cells by Regulating Extracellular Matrix Biomedicines 2022 10(10):2366 PubMed ID: 36289626 DOI: 10.3390/biomedicines10102366

21377 Shiraki N, Maruyama K, Hayashi R, Oguchi A, Murakawa Y, Katayama T, Takigawa T, Sakimoto S, Quantock AJ, Tsujikawa M, Nishida K. PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids. Stem Cell Reports 2022 17(2):221-230 PubMed ID: 35030319 DOI: 10.1016/j.stemcr.2021.12.009

22204 Ohno T, Akase T, Kono S, Kurasawa H, Takashima T, Kaneko S, Aizawa Y. Biallelic and gene-wide genomic substitution for endogenous intron and retroelement mutagenesis in human cells Nat Commun 2022 13(1):4219 PubMed ID: 35864085 DOI: 10.1038/s41467-022-31982-1

22205 Shimizu E, Iguchi H, Le MNT, Nakamura Y, Kobayashi D, Arai Y, Takakura K, Benno S, Yoshida N, Tsukahara M, Haneda S, Hasegawa K. A chemically-defined plastic scaffold for the xeno-free production of human pluripotent stem cells Sci Rep 2022 12(1):2516 PubMed ID: 35169157 DOI: 10.1038/s41598-022-06356-8

19237 Yamamoto-Shimojima K, Osawa M, Saito MK, Yamamoto T. Induced pluripotent stem cells established from a female patient with Xq22 deletion confirm that BEX2 escapes from X-chromosome inactivation Congenit Anom (Kyoto) 2021 61(2):63-67 PubMed ID: 33244819 DOI: 10.1111/cga.12403

19510 Nagai Y, Nakao H, Kojima A, Komatsubara Y, Ohta Y, Kawasaki N, Kawasaki N, Toyoda H, Kawasaki T. Glycan Epitopes on 201B7 Human-Induced Pluripotent Stem Cells Using R-10G and R-17F Marker Antibodies Biomolecules 2021 11(4):508 PubMed ID: 33805466 DOI: 10.3390/biom11040508

19539 Aghasafari P, Yang PC, Kernik DC, Sakamoto K, Kanda Y, Kurokawa J, Vorobyov I, Clancy CE. A deep learning algorithm to translate and classify cardiac electrophysiology Elife 2021 10:e68335 PubMed ID: 34212860 DOI: 10.7554/eLife.68335

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12197 Yuko Arioka, Emiko Shishido, Itaru Kushima, Toshiaki Suzuki, Ryo Saito, Atsu Aiba, Daisuke Mori, Norio Ozaki Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons EBioMedicine 2021 63:103138 PubMed ID: 33341442 DOI: 10.1016/j.ebiom.2020.103138

13237 Watanabe T, Yasuda S, Kusakawa S, Kuroda T, Futamura M, Ogawa M, Mochizuki H, Kikkawa E, Furukawa H, Nagaoka M, Sato Y. Multisite studies for validation and improvement of a highly efficient culture assay for detection of undifferentiated human pluripotent stem cells intermingled in cell therapy products. Cytotherapy 2021 PubMed ID: 32978066 DOI: 10.1016/j.jcyt.2020.07.009

13380 Fukusumi H, Togo K, Sumida M, Nakamori M, Obika S, Baba K, Shofuda T, Ito D, Okano H, Mochizuki H, Kanemura Y. Alpha-synuclein dynamics in induced pluripotent stem cell-derived dopaminergic neurons from a Parkinson's disease patient (PARK4) with SNCA triplication. FEBS Open Bio 2021 11(2):354-366 PubMed ID: 33301617 DOI: 10.1002/2211-5463.13060

20030 Yamanaka S, Matsui K, Fujimoto T, Takamura T, Saito Y, Matsumoto N, Tajiri S, Matsumoto K, Yokoo T. In vivo regeneration of neo-nephrons in rodents by renal progenitor cell transplantation. STAR Protoc 2021 2(1):100314 PubMed ID: 33554147 DOI: 10.1016/j.xpro.2021.100314

20034 Nomi K, Hayashi R, Ishikawa Y, Kobayashi Y, Katayama T, Quantock AJ, Nishida K. Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs. Cell Rep 2021 34(5):108715 PubMed ID: 33535050 DOI: 10.1016/j.celrep.2021.108715

20051 Oyane A, Araki H, Nakamura M, Aiki Y, Ito Y. Storable bFGF-Releasing Membrane Allowing Continuous Human iPSC Culture. Materials (Basel) 2021 14(3) PubMed ID: 33572553 DOI: 10.3390/ma14030651

20129 Hasegawa-Ogawa M, Okano HJ. Characterization of the upstream and intron promoters of the gene encoding TAR DNA-binding protein. Sci Rep 2021 11(1):8720 PubMed ID: 33888768 DOI: 10.1038/s41598-021-88015-y

20132 Akagi Y, Mori N, Kawamura T, Takayama Y, Kida YS. Non-invasive cell classification using the Paint Raman Express Spectroscopy System (PRESS). Sci Rep 2021 11(1):8818 PubMed ID: 33893362 DOI: 10.1038/s41598-021-88056-3

14068 Shimizu M, Tachikawa S, Saitoh N, Nakazono K, Yu-Jung L, Suga M, Ohnuma K. Thalidomide affects limb formation and multiple myeloma related genes in human induced pluripotent stem cells and their mesoderm differentiation Biochem Biophys Rep 2021 26:100978 PubMed ID: 33763605 DOI: 10.1016/j.bbrep.2021.100978

14073 Watanabe T, Tateno H. Elimination of cells deviated from human induced pluripotent stem cells with a photoactivatable IR700-labelled antibody Biochem Biophys Res Commun 2021 554:13-18 PubMed ID: 33774274 DOI: 10.1016/j.bbrc.2021.03.078

14076 Li J, Lee JK, Miwa K, Kuramoto Y, Masuyama K, Yasutake H, Tomoyama S, Nakanishi H, Sakata Y. Scaffold-Mediated Developmental Effects on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Are Preserved After External Support Removal Front Cell Dev Biol 2021 9:591754 PubMed ID: 33659246 DOI: 10.3389/fcell.2021.591754

20141 Yasutake H, Lee JK, Hashimoto A, Masuyama K, Li J, Kuramoto Y, Higo S, Hikoso S, Hidaka K, Naito AT, Miyagawa S, Sawa Y, Komuro I, Sakata Y. Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes. Sci Rep 2021 11(1):10351 PubMed ID: 33990626 DOI: 10.1038/s41598-021-89603-8

20144 Fukunaga I, Oe Y, Danzaki K, Ohta S, Chen C, Shirai K, Kawano A, Ikeda K, Kamiya K. Modeling gap junction beta 2 gene-related deafness with human iPSC. Hum Mol Genet 2021 PubMed ID: 33997905 DOI: 10.1093/hmg/ddab097

20221 Sato M, Inohaya A, Yasuda E, Mogami H, Chigusa Y, Kawasaki K, Kawamura Y, Ueda Y, Takai H, Mandai M, Kondoh E. Three-dimensional human placenta-like bud synthesized from induced pluripotent stem cells Sci Rep 2021 11(1):14167 PubMed ID: 34239021 DOI: 10.1038/s41598-021-93766-9

20303 Watanabe S, Hayashi R, Sasamoto Y, Tsujikawa M, Ksander BR, Frank MH, Quantock AJ, Frank NY, Nishida K. Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities. iScience 2021 24(6):102688 PubMed ID: 34195566 DOI: 10.1016/j.isci.2021.102688

20318 Hori Y, Shimamoto A, Kobayashi T. The human ribosomal DNA array is composed of highly homogenized tandem clusters. Genome Res 2021 PubMed ID: 34407983 DOI: 10.1101/gr.275838.121

15460 Minoshima F, Ozaki H, Odaka H, Tateno H. Integrated analysis of glycan and RNA in single cells iScience 2021 24(8):102882 PubMed ID: 34401666 DOI: 10.1016/j.isci.2021.102882

15519 Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, Kanagaki S, Namba T, Yamamoto Y, Xu Y, Takeuchi K, Adachi Y, Chen-Yoshikawa TF, Date H, Hagiwara M, Tsukita S, Hirai T, Torisawa YS, Gotoh S. Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology Sci Transl Med 2021 13(601):eabb1298 PubMed ID: 34233948 DOI: 10.1126/scitranslmed.abb1298

15522 Kikuchi T, Matsuura K, Shimizu T. Non-coating method for non-adherent cell culture using high molecular weight dextran sulfate and bovine serum albumin J Biosci Bioeng 2021 S1389-1723(21)00209-7 PubMed ID: 34518107 DOI: 10.1016/j.jbiosc.2021.08.006

15525 Horikawa A, Mizuno K, Tsuda K, Yamamoto T, Michiue T. A simple method of hiPSCs differentiation into insulin-producing cells is improved with vitamin C and RepSox PLoS One 2021 16(7):e0254373 PubMed ID: 34252142 DOI: 10.1371/journal.pone.0254373

20435 Miyake T, Kuge M, Matsumoto Y, Shimada M. α-glucosyl-rutin activates immediate early genes in human induced pluripotent stem cells. Stem Cell Res 2021 56:102511 PubMed ID: 34455240 DOI: 10.1016/j.scr.2021.102511

15884 Akihiro Morita, Yuta Omoya, Rie Ito, Yuya Ishibashi, Keiichi Hiramoto, Shiho Ohnishi, Nobuji Yoshikawa, Shosuke Kawanishi Glycyrrhizin and its derivatives promote hepatic differentiation via sweet receptor, Wnt, and Notch signaling Biochemistry and Biophysics Reports 2021 28:101181 PubMed ID: 34934826 DOI: 10.1016/j.bbrep.2021.101181

20474 Chu SL, Abe K, Yokota H, Cho D, Chen YH, Tsai MD. High Resolution U-Net for Quantitatively Analyzing Early Spatial Patterning of Human Induced Pluripotent Stem Cells on Micropatterns. Annu Int Conf IEEE Eng Med Biol Soc 2021 3713-3716 PubMed ID: 34892043 DOI: 10.1109/EMBC46164.2021.9630956

20491 Tadokoro S, Tokuyama-Toda R, Tatehara S, Ide S, Umeki H, Miyoshi K, Noma T, Satomura K. A New Induction Method for the Controlled Differentiation of Human-Induced Pluripotent Stem Cells Using Frozen Sections. Cells 2021 10(11) PubMed ID: 34831050 DOI: 10.3390/cells10112827

20508 Lee HS, Mok J, Joo CK. Bone Morphogenetic Protein 4 (BMP4) Enhances the Differentiation of Human Induced Pluripotent Stem Cells into Limbal Progenitor Cells. Curr Issues Mol Biol 2021 43(3):2124-2134 PubMed ID: 34940121 DOI: 10.3390/cimb43030147

16880 Taniguchi-Ikeda M, Koyanagi-Aoi M, Maruyama T, Takaori T, Hosoya A, Tezuka H, Nagase S, Ishihara T, Kadoshima T, Muguruma K, Ishigaki K, Sakurai H, Mizoguchi A, Novitch BG, Toda T, Watanabe M, Aoi T. Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy iScience 2021 24(10):103140 PubMed ID: 34632335 DOI: 10.1016/j.isci.2021.103140

17418 Yamasaki Y, Matsuura K, Sasaki D, Shimizu T. Assessment of human bioengineered cardiac tissue function in hypoxic and re-oxygenized environments to understand functional recovery in heart failure Regen Ther 2021 18:66-75 PubMed ID: 33869689 DOI: 10.1016/j.reth.2021.03.007

17420 Ohya T, Ohtomo H, Kikuchi T, Sasaki D, Kawamura Y, Matsuura K, Shimizu T, Fukuda K, Someya T, Umezu S. Simultaneous measurement of contractile force and field potential of dynamically beating human iPS cell-derived cardiac cell sheet-tissue with flexible electronics Lab Chip 2021 21(20):3899-3909 PubMed ID: 34636821 DOI: 10.1039/d1lc00411e

19241 Haramoto Y, Onuma Y, Mawaribuchi S, Nakajima Y, Aiki Y, Higuchi K, Shimizu M, Tateno H, Hirabayashi J, Ito Y. A technique for removing tumourigenic pluripotent stem cells using rBC2LCN lectin Regen Ther 2020 14:306-314 PubMed ID: 32462059 DOI: 10.1016/j.reth.2020.03.017

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11778 Tateno H, Hiemori K, Minoshima F, Kiyoi K, Matoba K, Katayama J, Kumada Y. Oriented immobilization of rBC2LCN lectin for highly sensitive detection of human pluripotent stem cells using cell culture supernatants. J. Biosci. Bioeng. 2020 129(2):215-222. PubMed ID: 31473147 DOI: 10.1016/j.jbiosc.2019.08.003

11841 Yoda K, Ohnuki Y, Masui S, Kurosawa H. Optimized conditions for the supplementation of human-induced pluripotent stem cell cultures with a GSK-3 inhibitor during embryoid body formation with the aim of inducing differentiation into mesodermal and cardiac lineage. J. Biosci. Bioeng. 2020 PubMed ID: 31615734 DOI: 10.1016/j.jbiosc.2019.09.015

11879 Morishige S, Mizuno S, Ozawa H, Nakamura T, Mazahery A, Nomura K, Seki R, Mouri F, Osaki K, Yamamura K, Okamura T, Nagafuji K. CRISPR/Cas9-mediated gene correction in hemophilia B patient-derived iPSCs. Int. J. Hematol. 2020 PubMed ID: 31664646 DOI: 10.1007/s12185-019-02765-0

6879 Kasai T, Suga H, Sakakibara M, Ozone C, Matsumoto R, Kano M, Mitsumoto K, Ogawa K, Kodani Y, Nagasaki H, Inoshita N, Sugiyama M, Onoue T, Tsunekawa T, Ito Y, Takagi H, Hagiwara D, Iwama S, Goto M, Banno R, Takahashi J, Arima H. Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells. Cell Rep 2020 30(1):18-24 PubMed ID: 31914385 DOI: 10.1016/j.celrep.2019.12.009

9933 Shun Shibata, Ryuhei Hayashi, Yuji Kudo, Toru Okubo, Tsutomu Imaizumi, Tomohiko Katayama, Yuki Ishikawa, Yuki Kobayashi, Junko Toga, Yukimasa Taniguchi, Yoichi Honma, Kiyotoshi Sekiguchi, Kohji Nishida Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium Stem Cell Reports 2020 14(4):663-676 PubMed ID: 32197114 DOI: 10.1016/j.stemcr.2020.02.008

11938 Hashida A, Uemura T, Kino-Oka M. Kinetics on aggregate behaviors of human induced pluripotent stem cells in static suspension and rotating flow cultures. J. Biosci. Bioeng. 2020 PubMed ID: 31826834 DOI: 10.1016/j.jbiosc.2019.11.005

12000 Zujur D, Kanke K, Onodera S, Tani S, Lai J, Azuma T, Xin X, Lichtler AC, Rowe DW, Saito T, Tanaka S, Masaki H, Nakauchi H, Chung UI, Hojo H, Ohba S. Stepwise strategy for generating osteoblasts from human pluripotent stem cells under fully defined xeno-free conditions with small-molecule inducers. Regen Ther 2020 PubMed ID: 31988991 DOI: 10.1016/j.reth.2019.12.010

12042 Ninomiya H, Intoh A, Ishimine H, Onuma Y, Ito Y, Michiue T, Tazaki A, Kato M. Application of a human mesoderm tissue elongation system in vitro derived from human induced pluripotent stem cells to risk assessment for teratogenic chemicals. Chemosphere 2020 PubMed ID: 32092576 DOI: 10.1016/j.chemosphere.2020.126124

12079 Umehara Y, Toyama S, Tominaga M, Matsuda H, Takahashi N, Kamata Y, Niyonsaba F, Ogawa H, Takamori K. Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Sci Rep 2020 PubMed ID: 32152328 DOI: 10.1038/s41598-020-60036-z

13105 Takayama Y, Kushige H, Akagi Y, Suzuki Y, Kumagai Y, Kida YS. Selective Induction of Human Autonomic Neurons Enables Precise Control of Cardiomyocyte Beating. Sci Rep 2020 PubMed ID: 32528170 DOI: 10.1038/s41598-020-66303-3

13124 Watanabe T, Saito S, Hiemori K, Kiyoi K, Mawaribuchi S, Haramoto Y, Tateno H. SSEA-1-positive fibronectin is secreted by cells deviated from the undifferentiated state of human induced pluripotent stem cells. Biochem Biophys Res Commun 2020 PubMed ID: 32736676 DOI: 10.1016/j.bbrc.2020.06.074

13166 Ito A, Yoshioka K, Masumoto S, Sato K, Hatae Y, Nakai T, Yamazaki T, Takahashi M, Tanoue S, Horie M. Magnetic heating of nanoparticles as a scalable cryopreservation technology for human induced pluripotent stem cells. Sci Rep 2020 PubMed ID: 32788637 DOI: 10.1038/s41598-020-70707-6

13213 Watanabe T, Kakuta J, Saito S, Hasehira K, Kiyoi K, Imai T, Tateno H. Monoclonal antibodies specific for podocalyxin expressed on human induced pluripotent stem cells. Biochem Biophys Res Commun 2020 PubMed ID: 32912628 DOI: 10.1016/j.bbrc.2020.08.092

13218 Fujimoto T, Yamanaka S, Tajiri S, Takamura T, Saito Y, Matsumoto N, Matsumoto K, Tachibana T, Okano HJ, Yokoo T. Generation of Human Renal Vesicles in Mouse Organ Niche Using Nephron Progenitor Cell Replacement System. Cell Rep 2020 PubMed ID: 32937125 DOI: 10.1016/j.celrep.2020.108130

13370 Xu L, Hanamatsu H, Homan K, Onodera T, Miyazaki T, Furukawa JI, Hontani K, Tian Y, Baba R, Iwasaki N. Alterations of Glycosphingolipid Glycans and Chondrogenic Markers during Differentiation of Human Induced Pluripotent Stem Cells into Chondrocytes. Biomolecules 2020 PubMed ID: 33271874 DOI: 10.3390/biom10121622

13487 Hidaka T, Tsubono Y, Hashiya K, Bando T, Pandian GN, Sugiyama H. Enhanced nuclear accumulation of pyrrole-imidazole polyamides by incorporation of the tri-arginine vector Chem Commun (Camb) 2020 56(82):12371-12374 PubMed ID: 32930253 DOI: 10.1039/d0cc05158f

13607 Nakamura T, Morishige S, Ozawa H, Kuboyama K, Yamasaki Y, Oya S, Yamaguchi M, Aoyama K, Seki R, Mouri F, Osaki K, Okamura T, Mizuno S, Nagafuji K. Successful correction of factor V deficiency of patient-derived iPSCs by CRISPR/Cas9-mediated gene editing Haemophilia 2020 26(5):826-833 PubMed ID: 32700411 DOI: 10.1111/hae.14104

13615 Tateno H. Expression and Purification of a Human Pluripotent Stem Cell-Specific Lectin Probe, rBC2LCN Methods Mol Biol 2020 2132:453-461 PubMed ID: 32306352 DOI: 10.1007/978-1-0716-0430-4_44

13782 Homma J, Shimizu S, Sekine H, Matsuura K, Shimizu T. A novel method to align cells in a cardiac tissue-like construct fabricated by cell sheet-based tissue engineering J Tissue Eng Regen Med 2020 14(7):944-954 PubMed ID: 32478904 DOI: 10.1002/term.3074

14604 Sakaguchi K, Takahashi H, Tobe Y, Sasaki D, Matsuura K, Iwasaki K, Shimizu T, Umezu M. Measuring the Contractile Force of Multilayered Human Cardiac Cell Sheets Tissue Eng Part C Methods 2020 26(9):485-492 PubMed ID: 32799760 DOI: 10.1089/ten.TEC.2020.0164

19492 Kanie K, Bando H, Iguchi G, Muguruma K, Matsumoto R, Hidaka-Takeno R, Okimura Y, Yamamoto M, Fujita Y, Fukuoka H, Yoshida K, Suda K, Nishizawa H, Ogawa W, Takahashi Y. Pathogenesis of Anti-PIT-1 Antibody Syndrome: PIT-1 Presentation by HLA Class I on Anterior Pituitary Cells J Endocr Soc 2019 3(11):1969-1978 PubMed ID: 31620667 DOI: 10.1210/js.2019-00243

19493 Miyazaki T, Hanamatsu H, Xu L, Onodera T, Furukawa JI, Homan K, Baba R, Kawasaki T, Iwasaki N. Stem Cells in Human Chondrocytes by Cell Type-Specific Glycosphingolipid Glycome Analysis Based on the Aminolysis-SALSA Technique Int J Mol Sci 2019 21(1):231 PubMed ID: 31905707 DOI: 10.3390/ijms21010231

19509 to K, Matsuura K, Mihara Y, Sakamoto Y, Hasegawa K, Kokudo N, Shimizu T. Delivery of pancreatic digestive enzymes into the gastrointestinal tract by pancreatic exocrine tissue transplant Sci Rep 2019 9(1):5922 PubMed ID: 30976035 DOI: 10.1038/s41598-019-42362-z

11235 Yoda K, Ohnuki Y, Kurosawa H. Optimization of the treatment conditions with glycogen synthase kinase-3 inhibitor towards enhancing the proliferation of human induced pluripotent stem cells while maintaining an undifferentiated state under feeder-free conditions. J. Biosci. Bioeng. 2019 127(3):381-387 PubMed ID: 30292671 DOI: 10.1016/j.jbiosc.2018.09.002

11391 Iwasawa C, Kuzumaki N, Suda Y, Kagawa R, Oka Y, Hattori N, Okano H, Narita M. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations. Mol Brain 2019 PubMed ID: 30658665 DOI: 10.1186/s13041-019-0426-7

11424 Dion J, Minoshima F, Saito S, Kiyoi K, Hasehira K, Tateno H. Photoactivable elimination of tumorigenic human induced pluripotent stem cells using a lectin-doxorubicin prodrug conjugate. Chembiochem 2019 PubMed ID: 30737871 DOI: 10.1002/cbic.201900086

11468 Kono K, Sawada R, Kuroda T, Yasuda S, Matsuyama S, Matsuyama A, Mizuguchi H, Sato Y. Development of selective cytotoxic viral vectors for concentration of undifferentiated cells in cardiomyocytes derived from human induced pluripotent stem cells. Sci Rep 2019 PubMed ID: 30842516 DOI: 10.1038/s41598-018-36848-5

4572 Kuroda T, Yasuda S, Tachi S, Matsuyama S, Kusakawa S, Tano K, Miura T, Matsuyama A, Sato Y. SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation. Nat Commun 2019 10(1):2175 PubMed ID: 31092818 DOI: 10.1038/s41467-019-09511-4

11516 Matsushita S, Kajiwara T, Mizumoto H. Expansion and differentiation of human iPS cells in a three-dimensional culture using hollow fibers and separation of the specific population by magnetic-activated cell sorting. J. Biosci. Bioeng. 2019 PubMed ID: 30982708 DOI: 10.1016/j.jbiosc.2019.03.014

11531 Kuzumaki N, Suda Y, Iwasawa C, Narita M, Sone T, Watanabe M, Maekawa A, Matsumoto T, Akamatsu W, Igarashi K, Tamura H, Takeshima H, Tawfik VL, Ushijima T, Hattori N, Okano H, Narita M. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson's disease. Brain 2019 PubMed ID: 31135049 DOI: 10.1093/brain/awz084

11576 Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y, Tomonaga K. RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs. Mol Ther Methods Clin Dev 2019 14:47-55 PubMed ID: 31309127 DOI: 10.1016/j.omtm.2019.05.010

11653 Nao Yamaoka, Kazunori Shimizu, Yu Imaizumi, Takuji Ito, Yohei Okada, Hiroyuki Honda Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions BioChip Journal 2019 DOI: 10.1007/s13206-018-3202-3

11679 Sachiko Sekiya, Tetsutaro Kikuchi, Tatsuya Shimizu Perfusion culture maintained with an air-liquid interface to stimulate epithelial cell organization in renal organoids in vitro BMC Biomedical Engineering 2019 1:15 PubMed ID: 32903332 DOI: 10.1186/s42490-019-0017-9

11788 Shoji M, Ueda M, Nishioka M, Minato H, Seki M, Harada K, Kubo M, Fukuyama Y, Suzuki Y, Aoyama E, Takigawa M, Kuzuhara T. Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 31506177 DOI: 10.1016/j.bbrc.2019.09.003

11798 Sugawara Y, Hamada K, Yamada Y, Kumai J, Kanagawa M, Kobayashi K, Toda T, Negishi Y, Katagiri F, Hozumi K, Nomizu M, Kikkawa Y. Characterization of dystroglycan binding in adhesion of human induced pluripotent stem cells to laminin-511 E8 fragment. Sci Rep 2019 PubMed ID: 31506597 DOI: 10.1038/s41598-019-49669-x

11875 Shimada M, Tsukada K, Kagawa N, Matsumoto Y. Reprogramming and differentiation-dependent transcriptional alteration of DNA damage response and apoptosis genes in human induced pluripotent stem cells. J. Radiat. Res. 2019 PubMed ID: 31665364 DOI: 10.1093/jrr/rrz057

10103 Tomoko Miyake, Mikio Shimada, Yoshihisa Matsumoto, Akitoshi Okino DNA Damage Response After Ionizing Radiation Exposure in Skin Keratinocytes Derived From Human-Induced Pluripotent Stem Cells Int J Radiat Oncol Biol Phys . 2019 105(1):193-205 PubMed ID: 31085283 DOI: 10.1016/j.ijrobp.2019.05.006

11968 Hayakawa K, Nishitani K, Tanaka S. Kynurenine, 3-OH-kynurenine, and anthranilate are nutrient metabolites that alter H3K4 trimethylation and H2AS40 O-GlcNAcylation at hypothalamus-related loci. Sci Rep 2019 PubMed ID: 31875008 DOI: 10.1038/s41598-019-56341-x

12138 Takayuki Nakamura, MD, Shinichi Mizuno, MD PhD, Hidetoshi Ozawa, Yoshitaka Yamasaki, MD, Shuki Oya, MD, Satoshi Morishige, MD, Kazutoshi Aoyama, MD PhD, Maki Ymaguchi, MD PhD, Ritsuko Seki, PhD, Fumihiko Mouri, MD PhD, Koichi Osaki, MD, Koji Nagafuji, MD PhD A Functional Analysis of SNP on Anthracycline-Induced Cardiotoxicity in a Uniform Genetic Background Using CRISPR/Cas9 Mediated Single-Base-Edited iPSCs Blood 2019 DOI: 10.1182/blood-2019-123932

12141 Ayako Oyane, Hiroko Araki, Maki Nakamura, Yasuhiko Aiki, Kumiko Higuchi, Alexander Pyatenko, Masaki Adachi and Yuzuru Ito Controlled release of basic fibroblast growth factor from a water-floatable polyethylene nonwoven fabric sheet for maintenance culture of iPSCs RSC Adv 2019 10(1):95-104 PubMed ID: 35492512 DOI: 10.1039/C9RA06906B

12334 Wei H, Wang C, Guo R, Takahashi K, Naruse K. Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells Biochem Biophys Res Commun 2019 520(3):600-605 PubMed ID: 31623826 DOI: 10.1016/j.bbrc.2019.09.119

12355 Okuyama H, Ohnishi H, Nakamura R, Yamashita M, Kishimoto Y, Tateya I, Suehiro A, Gotoh S, Takezawa T, Nakamura T, Omori K. Transplantation of multiciliated airway cells derived from human iPS cells using an artificial tracheal patch into rat trachea J Tissue Eng Regen Med 2019 13(6):1019-1030 PubMed ID: 30809958 DOI: 10.1002/term.2849

12356 Tsuruyama S, Matsuura K, Sakaguchi K, Shimizu T. Pulsatile tubular cardiac tissues fabricated by wrapping human iPS cells-derived cardiomyocyte sheets Regen Ther 2019 11:297-305 PubMed ID: 31667209 DOI: 10.1016/j.reth.2019.09.001

12357 Inui A, Sekine H, Sano K, Dobashi I, Yoshida A, Matsuura K, Kobayashi E, Ono M, Shimizu T. Generation of a large-scale vascular bed for the in vitro creation of three-dimensional cardiac tissue Regen Ther 2019 11:316-323 PubMed ID: 31687425 DOI: 10.1016/j.reth.2019.10.001

12358 Ito E, Miyagawa S, Takeda M, Kawamura A, Harada A, Iseoka H, Yajima S, Sougawa N, Mochizuki-Oda N, Yasuda S, Sato Y, Sawa Y. Tumorigenicity assay essential for facilitating safety studies of hiPSC-derived cardiomyocytes for clinical application Sci Rep 2019 9(1):1881 PubMed ID: 30760836 DOI: 10.1038/s41598-018-38325-5

16886 Fujii S, Yoshida S, Inagaki E, Hatou S, Tsubota K, Takahashi M, Shimmura S, Sugita S. Immunological Properties of Neural Crest Cells Derived from Human Induced Pluripotent Stem Cells Stem Cells Dev 2019 28(1):28-43 PubMed ID: 30251915 DOI: 10.1089/scd.2018.0058

16889 Nakanishi H, Lee JK, Miwa K, Masuyama K, Yasutake H, Li J, Tomoyama S, Honda Y, Deguchi J, Tsujimoto S, Hidaka K, Miyagawa S, Sawa Y, Komuro I, Sakata Y. Geometrical Patterning and Constituent Cell Heterogeneity Facilitate Electrical Conduction Disturbances in a Human Induced Pluripotent Stem Cell-Based Platform: An In vitro Disease Model of Atrial Arrhythmias Front Physiol 2019 10:818 PubMed ID: 31316396 DOI: 10.3389/fphys.2019.00818

7001 Akiyama T, Sato S, Chikazawa-Nohtomi N, Soma A, Kimura H, Wakabayashi S, Ko SBH, Ko MSH. Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing. Sci Rep 2018 8:1189 PubMed ID: 29352121 DOI: 10.1038/s41598-017-19114-y

7003 Yamamoto T, Takenaka C, Yoda Y, Oshima Y, Kagawa K, Miyajima H, Sasaki T, Kawamata S. Differentiation potential of Pluripotent Stem Cells correlates to the level of CHD7. Sci Rep 2018 8:241 PubMed ID: 29321579 DOI: 10.1038/s41598-017-18439-y

10630 Matsumura W, Fujita Y, Nakayama C, Shinkuma S, Suzuki S, Nomura T, Abe R, Shimizu H. Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes. J. Dermatol. Sci. 2018 89:263-271 PubMed ID: 29229433 DOI: 10.1016/j.jdermsci.2017.11.017

10758 Suda Y, Kuzumaki N, Sone T, Narita M, Tanaka K, Hamada Y, Iwasawa C, Shibasaki M, Maekawa A, Matsuo M, Akamatsu W, Hattori N, Okano H, Narita M. Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson's disease-like motor dysfunction. Mol Brain 2018 11:6 PubMed ID: 29458391 DOI: 10.1186/s13041-018-0349-8

10777 Saito S, Hiemori K, Kiyoi K, Tateno H. Glycome analysis of extracellular vesicles derived from human induced pluripotent stem cells using lectin microarray. Sci Rep 2018 8:3997 PubMed ID: 29507392 DOI: 10.1038/s41598-018-22450-2

10813 Sugimoto K, Matsuura T, Nakazono A, Igawa K, Yamada S, Hayashi Y. Effects of hypoxia inducible factors on pluripotency in human iPS cells. Microsc. Res. Tech. 2018 81(7):749-754 PubMed ID: 29633433 DOI: 10.1002/jemt.23032

10815 Lee JY, Han SH, Park MH, Baek B, Song IS, Choi MK, Takuwa Y, Ryu H, Kim SH, He X, Schuchman EH, Bae JS, Jin HK. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun 2018 9:1479 PubMed ID: 29662056 DOI: 10.1038/s41467-018-03674-2

10821 Tashiro S, Le MNT, Kusama Y, Nakatani E, Suga M, Furue MK, Satoh T, Sugiura S, Kanamori T, Ohnuma K. High cell density suppresses BMP4-induced differentiation of human pluripotent stem cells to produce macroscopic spatial patterning in a unidirectional perfusion culture chamber. J. Biosci. Bioeng. 2018 126(3):379-388 PubMed ID: 29681444 DOI: 10.1016/j.jbiosc.2018.03.007

11055 Hayashi Y, Matsumoto J, Kumagai S, Morishita K, Xiang L, Kobori Y, Hori S, Suzuki M, Kanamori T, Hotta K, Sumaru K. Automated Adherent Cell Elimination by a High-Speed Laser Mediated by a LightResponsive Polymer Commun Biol 2018 1:218 PubMed ID: 30534610 DOI: 10.1038/s42003-018-0222-4

11135 Arioka Y, Shishido E, Kubo H, Kushima I, Yoshimi A, Kimura H, Ishizuka K, Aleksic B, Maeda T, Ishikawa M, Kuzumaki N, Okano H, Mori D, Ozaki N. Single-cell trajectory analysis of human homogenous neurons carrying a rare RELN variant. Transl Psychiatry 2018 8(1):129 PubMed ID: 30022058 DOI: 10.1038/s41398-018-0177-8

11178 Nagashima T, Shimizu K, Matsumoto R, Honda H. Selective Elimination of Human Induced Pluripotent Stem Cells Using Medium with High Concentration of L-Alanine. Sci Rep 2018 8(1):12427 PubMed ID: 30127448 DOI: 10.1038/s41598-018-30936-2

11131 Haraguchi Y, Matsuura K, Kagawa Y, Hasegawa A, Kubo H, Shimizu T. Rapid creation system of morphologically and functionally communicative three-dimensional cell-dense tissue by centrifugation. Biotechnol. Prog. 2018 34(6):1447-1453 PubMed ID: 30009512 DOI: 10.1002/btpr.2691

11208 Yamamoto Y, Miyazaki S, Maruyama K, Kobayashi R, Le MNT, Kano A, Kondow A, Fujii S, Ohnuma K. Random migration of induced pluripotent stem cell-derived human gastrulation-stage mesendoderm. PLoS ONE 2018 PubMed ID: 30199537 DOI: 10.1371/journal.pone.0201960

11123 Tsuburaya N, Homma K, Higuchi T, Balia A, Yamakoshi H, Shibata N, Nakamura S, Nakagawa H, Ikeda SI, Umezawa N, Kato N, Yokoshima S, Shibuya M, Shimonishi M, Kojima H, Okabe T, Nagano T, Naguro I, Imamura K, Inoue H, Fujisawa T, Ichijo H. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun 2018 9(1):2668 PubMed ID: 29991716 DOI: 10.1038/s41467-018-05127-2

11234 Yasuda S, Kusakawa S, Kuroda T, Miura T, Tano K, Takada N, Matsuyama S, Matsuyama A, Nasu M, Umezawa A, Hayakawa T, Tsutsumi H, Sato Y. Tumorigenicity-associated characteristics of human iPS cell lines. PLoS ONE 2018 PubMed ID: 30286143 DOI: 10.1371/journal.pone.0205022

4048 Shibata S, Hayashi R, Okubo T, Kudo Y, Katayama T, Ishikawa Y, Toga J, Yagi E, Honma Y, Quantock AJ, Sekiguchi K, Nishida K. Selective Laminin-Directed Differentiation of Human Induced Pluripotent Stem Cells into Distinct Ocular Lineages Cell Rep 2018 25(6):1668-1679 PubMed ID: 30404017 DOI: 10.1016/j.celrep.2018.10.032

11240 Tajiri S, Yamanaka S, Fujimoto T, Matsumoto K, Taguchi A, Nishinakamura R, Okano HJ, Yokoo T. Regenerative potential of induced pluripotent stem cells derived from patients undergoing haemodialysis in kidney regeneration. Sci Rep 2018 PubMed ID: 30297790 DOI: 10.1038/s41598-018-33256-7

11251 Murata H, Khine CC, Nishikawa A, Yamamoto KI, Kinoshita R, Sakaguchi M. c-Jun N-terminal kinase (JNK)-mediated phosphorylation of SARM1 regulates NAD+ cleavage activity to inhibit mitochondrial respiration. J. Biol. Chem. 2018 PubMed ID: 30333228 DOI: 10.1074/jbc.RA118.004578

11290 Hayashi R, Ishikawa Y, Katayama T, Quantock AJ, Nishida K. CD200 facilitates the isolation of corneal epithelial cells derived from human pluripotent stem cells. Sci Rep 2018 PubMed ID: 30410112 DOI: 10.1038/s41598-018-34845-2

4068 Takako Tsugata, Naruo Nikoh, Tatsuya Kin, Chika Miyagi-Shiohira, Yoshiki Nakashima, Issei Saitoh, Yasufumi Noguchi, Hideo Ueki, Masami Watanabe6 Naoya Kobayashi, Andrew M. James Shapiro2 Hirofumi Noguchi Role of Egr1 on Pancreatic Endoderm Differentiation Cell Medicine 2018 10 PubMed ID: 32634182 DOI: 10.1177/2155179017733177

4111 Ide K, Mitsui K, Irie R, Matsushita Y, Ijichi N, Toyodome S, Kosai KI. A Novel Construction of Lentiviral Vectors for Eliminating Tumorigenic Cells from Pluripotent Stem Cells. Stem Cells 2018 PubMed ID: 29067732 DOI: 10.1002/stem.2725

4112 Tachikawa S, Shimizu M, Maruyama K, Ohnuma K. Thalidomide induces apoptosis during early mesodermal differentiation of human induced pluripotent stem cells. In Vitro Cell. Dev. Biol. Anim. 2018 PubMed ID: 29435726 DOI: 10.1007/s11626-018-0234-x

4113 Shoji M, Minato H, Ogaki S, Seki M, Suzuki Y, Kume S, Kuzuhara T. Different murine-derived feeder cells alter the definitive endoderm differentiation of human induced pluripotent stem cells. PLoS ONE 2018 PubMed ID: 30048506 DOI: 10.1371/journal.pone.0201239

4114 Eto S, Goto M, Soga M, Kaneko Y, Uehara Y, Mizuta H, Era T. Mesenchymal stem cells derived from human iPS cells via mesoderm and neuroepithelium have different features and therapeutic potentials. PLoS ONE 2018 PubMed ID: 30044827 DOI: 10.1371/journal.pone.0200790

4115 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Oct3/4 is potentially useful for the suppression of the proliferation and motility of hepatocellular carcinoma cells. Oncol Lett 2018 PubMed ID: 30250594 DOI: 10.3892/ol.2018.9292

4456 Matsuura K, Ito K, Shiraki N, Kume S, Hagiwara N, Shimizu T. Induced Pluripotent Stem Cell Elimination in a Cell Sheet by Methionine-Free and 42°C Condition for Tumor Prevention. Tissue Eng Part C Methods 2018 24(10):605-615 PubMed ID: 30234460 DOI: 10.1089/ten.TEC.2018.0228

4457 Kikuchi T, Kino-Oka M, Wada M, Kobayashi T, Kato M, Takeda S, Kubo H, Ogawa T, Sunayama H, Tanimoto K, Mizutani M, Shimizu T, Okano T. A novel, flexible and automated manufacturing facility for cell-based health care products: Tissue Factory. Regen Ther 2018 9:89-99 PubMed ID: 30525079 DOI: 10.1016/j.reth.2018.08.004

4458 Kobayashi H, Ebisawa K, Kambe M, Kasai T, Suga H, Nakamura K, Narita Y, Ogata A, Kamei Y. ＜Editors' Choice＞ Effects of exosomes derived from the induced pluripotent stem cells on skin wound healing. Nagoya J Med Sci 2018 80(2):141-153 PubMed ID: 29915432 DOI: 10.18999/nagjms.80.2.141

4459 Sasaki D, Matsuura K, Seta H, Haraguchi Y, Okano T, Shimizu T. Contractile force measurement of human induced pluripotent stem cell-derived cardiac cell sheet-tissue. PLoS ONE 2018 13(5):e0198026 PubMed ID: 29791489 DOI: 10.1371/journal.pone.0198026

4460 Hamano S, Tomokiyo A, Hasegawa D, Yoshida S, Sugii H, Mitarai H, Fujino S, Wada N, Maeda H. Extracellular Matrix from Periodontal Ligament Cells Could Induce the Differentiation of Induced Pluripotent Stem Cells to Periodontal Ligament Stem Cell-Like Cells. Stem Cells Dev. 2018 27(2):100-111 PubMed ID: 29160151 DOI: 10.1089/scd.2017.0077

4461 Matsuda Y, Takahashi K, Kamioka H, Naruse K. Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes. Biochem. Biophys. Res. Commun. 2018 503(3):1798-1804 PubMed ID: 30060947 DOI: 10.1016/j.bbrc.2018.07.116

5773 Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M. A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin. Biotechnol J 2018 13(2) PubMed ID: 29027750 DOI: 10.1002/biot.201700384

5775 Kobayashi W, Onishi A, Tu HY, Takihara Y, Matsumura M, Tsujimoto K, Inatani M, Nakazawa T, Takahashi M. Culture Systems of Dissociated Mouse and Human Pluripotent Stem Cell-Derived Retinal Ganglion Cells Purified by Two-Step Immunopanning. Invest Ophthalmol Vis Sci 2018 59(2):776-787 PubMed ID: 29392326 DOI: 10.1167/iovs.17-22406

5776 Sumaru K, Takagi T, Morishita K, Kanamori T. Photoresponsive Aqueous Dissolution of Poly( N-Isopropylacrylamide) Functionalized with o-Nitrobenzaldehyde through Phase Transition. Biomacromolecules 2018 19(7):2913-2922 PubMed ID: 29641886 DOI: 10.1021/acs.biomac.8b00470

5777 Nakashima Y, Miyagi-Shiohira C, Noguchi H2, Omasa T. Atorvastatin Inhibits the HIF1α-PPAR Axis, Which Is Essential for Maintaining the Function of Human Induced Pluripotent Stem Cells. Mol Ther 2018 26(7):1715-1734 PubMed ID: 29929789 DOI: 10.1016/j.ymthe.2018.06.005

14923 Nakayama C, Fujita Y, Matsumura W, Ujiie I, Takashima S, Shinkuma S, Nomura T, Abe R, Shimizu H. The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes J Dermatol Sci 2018 91(3):301-310 PubMed ID: 29933899 DOI: 10.1016/j.jdermsci.2018.06.004

7014 Taguchi A, Nishinakamura R. Higher-Order Kidney Organogenesis from Pluripotent Stem Cells. Cell Stem Cell 2017 21(6):730-746 PubMed ID: 29129523 DOI: 10.1016/j.stem.2017.10.011

7022 Nihongaki Y, Furuhata Y, Otabe T, Hasegawa S, Yoshimoto K, Sato M. CRISPR-Cas9-based photoactivatable transcription systems to induce neuronal differentiation. Nat. Methods 2017 14:963-966 PubMed ID: 28892089 DOI: 10.1038/nmeth.4430

7037 Goparaju SK, Kohda K, Ibata K, Soma A, Nakatake Y, Akiyama T, Wakabayashi S, Matsushita M, Sakota M, Kimura H, Yuzaki M, Ko SB, Ko MS. Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors. Sci Rep 2017 7:42367 PubMed ID: 28205555 DOI: 10.1038/srep42367

9814 Suga M, Tachikawa S, Tateyama D, Ohnuma K, Furue MK. Imaging-cytometry revealed spatial heterogeneities of marker expression in undifferentiated human pluripotent stem cells. In Vitro Cell. Dev. Biol. Anim. 2017 53:83-91 PubMed ID: 27573412 DOI: 10.1007/s11626-016-0084-3

9842 Ozeki N, Hase N, Higuchi N, Hiyama T, Yamaguchi H, Kawai R, Matsumoto T, Nakata K, Mogi M. Gelatin scaffold combined with bone morphogenetic protein-4 induces odontoblast-like cell differentiation involving integrin profile changes, autophagy-related gene 10, and Wnt5 sequentially in human induced pluripotent stem cells. Differentiation 2017 93:1-14 PubMed ID: 27639333 DOI: 10.1016/j.diff.2016.09.002

10099 Ozeki N, Hase N, Hiyama T, Yamaguchi H, Kawai-Asano R, Nakata K, Mogi M. MicroRNA-211 and autophagy-related gene 14 signaling regulate osteoblast-like cell differentiation of human induced pluripotent stem cells. Exp. Cell Res. 2017 352:63-74 PubMed ID: 28159471 DOI: 10.1016/j.yexcr.2017.01.018

10124 Nagasaka R, Gotou Y, Yoshida K, Kanie K, Shimizu K, Honda H, Kato R. Image-based cell quality evaluation to detect irregularities under same culture process of human induced pluripotent stem cells. J. Biosci. Bioeng. 2017 123:642-650 PubMed ID: 28189491 DOI: 10.1016/j.jbiosc.2016.12.015

10162 Haraguchi Y, Hasegawa A, Matsuura K, Kobayashi M, Iwana SI, Kabetani Y, Shimizu T. Three-Dimensional Human Cardiac Tissue Engineered by Centrifugation of Stacked Cell Sheets and Cross-Sectional Observation of Its Synchronous Beatings by Optical Coherence Tomography. Biomed Res Int 2017 2017:5341702 PubMed ID: 28326324 DOI: 10.1155/2017/5341702

10212 Takahashi M, Saito A, Jimbo Y, Nakasono S. Evaluation of the effects of power-frequency magnetic fields on the electrical activity of cardiomyocytes differentiated from human induced pluripotent stem cells. J Toxicol Sci 2017 42:223-231 PubMed ID: 28321048 DOI: 10.2131/jts.42.223

10276 Kondo Y, Hattori K, Tashiro S, Nakatani E, Yoshimitsu R, Satoh T, Sugiura S, Kanamori T, Ohnuma K. Compartmentalized microfluidic perfusion system to culture human induced pluripotent stem cell aggregates. J. Biosci. Bioeng. 2017 124:234-241 PubMed ID: 28434976 DOI: 10.1016/j.jbiosc.2017.03.014

10279 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Differentiation of human induced pluripotent stem cells in William's E initiation medium supplemented with 3‑bromopyruvate and 2‑deoxy‑d‑glucose. Mol Med Rep 2017 15:3719-3723 PubMed ID: 28440498 DOI: 10.3892/mmr.2017.6474

10346 Ishikawa T. Next-generation sequencing traces human induced pluripotent stem cell lines clonally generated from heterogeneous cancer tissue. World J Stem Cells 2017 9:77-88 PubMed ID: 28596815 DOI: 10.4252/wjsc.v9.i5.77

10409 Bamba Y, Kanemura Y, Okano H, Yamasaki M. Visualization of migration of human cortical neurons generated from induced pluripotent stem cells. J. Neurosci. Methods 2017 289:57-63 PubMed ID: 28694214 DOI: 10.1016/j.jneumeth.2017.07.004

10426 Tateno H, Saito S. Engineering of a Potent Recombinant Lectin-Toxin Fusion Protein to Eliminate Human Pluripotent Stem Cells. Molecules 2017 22: PubMed ID: 28698527 DOI: 10.3390/molecules22071151

10447 Taniguchi J, Pandian GN, Hidaka T, Hashiya K, Bando T, Kim KK, Sugiyama H. A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm. Nucleic Acids Res. 2017 45:9219-9228 PubMed ID: 28934500 DOI: 10.1093/nar/gkx693

10484 Tachikawa S, Nishimura T, Nakauchi H, Ohnuma K. Thalidomide induces apoptosis in undifferentiated human induced pluripotent stem cells. In Vitro Cell. Dev. Biol. Anim. 2017 53:841-851 PubMed ID: 28849348 DOI: 10.1007/s11626-017-0192-8

10529 Hosoyama T, Ichida S, Kanno M, Ishihara R, Hatashima T, Ueno K, Hamano K. Microgravity influences maintenance of the human muscle stem/progenitor cell pool. Biochem. Biophys. Res. Commun. 2017 493:998-1003 PubMed ID: 28942144 DOI: 10.1016/j.bbrc.2017.09.103

10593 Hasegawa D, Ochiai-Shino H, Onodera S, Nakamura T, Saito A, Onda T, Watanabe K, Nishimura K, Ohtaka M, Nakanishi M, Kosaki K, Yamaguchi A, Shibahara T, Azuma T. Gorlin syndrome-derived induced pluripotent stem cells are hypersensitive to hedgehog-mediated osteogenic induction. PLoS ONE 2017 12:e0186879 PubMed ID: 29088246 DOI: 10.1371/journal.pone.0186879

10667 Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu D, Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M. Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta. Asian Spine J 2017 11:870-879 PubMed ID: 29279741 DOI: 10.4184/asj.2017.11.6.870

10690 Kavitha MS, Kurita T, Park SY, Chien SI, Bae JS, Ahn BC. Deep vector-based convolutional neural network approach for automatic recognition of colonies of induced pluripotent stem cells. PLoS ONE 2017 12:e0189974 PubMed ID: 29281701 DOI: 10.1371/journal.pone.0189974

4551 Hayashi R, Ishikawa Y, Katori R, Sasamoto Y, Taniwaki Y, Takayanagi H, Tsujikawa M, Sekiguchi K, Quantock AJ, Nishida K. Coordinated generation of multiple ocular-like cell lineages and fabrication of functional corneal epithelial cell sheets from human iPS cells. Nat Protoc 2017 12(4):683-696 PubMed ID: 28253236 DOI: 10.1038/nprot.2017.007

5760 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. 2‑Deoxy‑D‑glucose initiates hepatocyte differentiation in human induced pluripotent stem cells. Mol Med Rep 2017 15(5):3083-3087 PubMed ID: 28358426 DOI: 10.3892/mmr.2017.6405

5761 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Oncostatin M in William's E medium is suitable for initiation of hepatocyte differentiation in human induced pluripotent stem cells. Mol Med Rep 2017 15(5):3088-3092 PubMed ID: 28358419 DOI: 10.3892/mmr.2017.6406

5762 Hasehira K, Hirabayashi J, Tateno H. Structural and quantitative evidence of α2-6-sialylated N-glycans as markers of the differentiation potential of human mesenchymal stem cells. Glycoconj J 2017 34(6):797-806 PubMed ID: 27314244 DOI: 10.1007/s10719-016-9699-6

5763 K Sumaru et al Sectioning of cultured cell monolayer using photo-acid-generating substrate and micro-patterned light projection European Polymer Journal 2017 93:733-742 DOI: 10.1016/j.eurpolymj.2017.02.021

5764 Tani H, Okuda S, Nakamura K, Aoki M, Umemura T. Short-lived long non-coding RNAs as surrogate indicators for chemical exposure and LINC00152 and MALAT1 modulate their neighboring genes. PLoS One 2017 12(7):e0181628 PubMed ID: 28719640 DOI: 10.1371/journal.pone.0181628

5765 Tateno H et al Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media. Regen Ther 2017 6:1-8 PubMed ID: 30271833 DOI: 10.1016/j.reth.2016.12.002

5766 Suzuki N, Arimitsu N, Shimizu J, Takai K, Hirotsu C, Ueda Y, Wakisaka S, Fujiwara N, Suzuki T. Neuronal Cell Sheets of Cortical Motor Neuron Phenotype Derived from Human iPSCs. Cell Transplant 2017 26(8):1355-1364 PubMed ID: 28901192 DOI: 10.1177/0963689717720280

5767 Ito M, Sun S, Fukuhara T, Suzuki R, Tamai M, Yamauchi T, Nakashima K, Tagawa Y, Okazaki S, Matsuura Y, Wakita T, Suzuki T. Development of hepatoma-derived, bidirectional oval-like cells as a model to study host interactions with hepatitis C virus during differentiation. Oncotarget 2017 8(33):53899-53915 PubMed ID: 28903311 DOI: 10.18632/oncotarget.19108

5768 Alsayegh K, Matsuura K, Sekine H, Shimizu T. Dinaciclib potently suppresses MCL-1 and selectively induces the cell death in human iPS cells without affecting the viability of cardiac tissue. Sci Rep 2017 7:45577 PubMed ID: 28361959 DOI: 10.1038/srep45577

5769 Kuroda T, Yasuda S, Nakashima H, Takada N, Matsuyama S, Kusakawa S, Umezawa A, Matsuyama A, Kawamata S, Sato Y dentification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells. Sci Rep 2017 7(1):8163 PubMed ID: 28811571 DOI: 10.1038/s41598-017-08014-w

5770 Seta H, Matsuura K, Sekine H, Yamazaki K, Shimizu T. Tubular Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells Generate Pulse Pressure In Vivo. Sci Rep 2017 7:45499 PubMed ID: 28358136 DOI: 10.1038/srep45499

5771 Hayakawa K, Sakamoto Y, Kanie O, Ohtake A, Daikoku S, Ito Y, Shiota K. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics 2017 12(9):764-778 PubMed ID: 28762874 DOI: 10.1080/15592294.2017.1346775

5772 Sato M　etal Regeneration of cervical reserve cell-like cells from human induced pluripotent stem cells (iPSCs): A new approach to finding targets for cervical cancer stem cell treatment. Oncotarget 2017 8(25):40935-40945 PubMed ID: 28402962 DOI: 10.18632/oncotarget.16783

5774 Miyagoe-Suzuki Y, Nishiyama T, Nakamura M, Narita A, Takemura F, Masuda S, Minami N, Murayama K, Komaki H, Goto YI, Takeda S. Induction of Pluripotent Stem Cells from a Manifesting Carrier of Duchenne Muscular Dystrophy and Characterization of Their X-Inactivation Status. Stem Cells Int 2017 2017:7906843 PubMed ID: 28491099 DOI: 10.1155/2017/7906843

7048 Suzuki K, Kimura T, Shinoda H, Bai G, Daniels MJ, Arai Y, Nakano M, Nagai T. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun 2016 7:13718 PubMed ID: 27966527 DOI: 10.1038/ncomms13718

7080 Hayashi R, Ishikawa Y, Sasamoto Y, Katori R, Nomura N, Ichikawa T, Araki S, Soma T, Kawasaki S, Sekiguchi K, Quantock AJ, Tsujikawa M, Nishida K. Co-ordinated ocular development from human iPS cells and recovery of corneal function. Nature 2016 531:376-80 PubMed ID: 26958835 DOI: 10.1038/nature17000

7083 Matsuura K, Seta H, Haraguchi Y, Alsayegh K, Sekine H, Shimizu T, Hagiwara N, Yamazaki K, Okano T. TRPV-1-mediated elimination of residual iPS cells in bioengineered cardiac cell sheet tissues. Sci Rep 2016 6:21747 PubMed ID: 26888607 DOI: 10.1038/srep21747

7315 Imaizumi K, Iha M, Nishishita N, Kawamata S, Nishikawa S, Akuta T. A Simple and Efficient Method of Slow Freezing for Human Embryonic Stem Cells and Induced Pluripotent Stem Cells. Methods Mol. Biol. 2016 1341:15-24 PubMed ID: 26069023 DOI: 10.1007/7651_2015_211

7326 Kim SI, Oceguera-Yanez F, Sakurai C, Nakagawa M, Yamanaka S, Woltjen K. Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol. Biol. 2016 1357:111-31 PubMed ID: 26025620 DOI: 10.1007/7651_2015_251

9529 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Transcription Factors and Medium Suitable for Initiating the Differentiation of Human-Induced Pluripotent Stem Cells to the Hepatocyte Lineage. J. Cell. Biochem. 2016 117:2001-9 PubMed ID: 26773721 DOI: 10.1002/jcb.25494

9535 Shoji M, Nishioka M, Minato H, Harada K, Kubo M, Fukuyama Y, Kuzuhara T. Neurotrophic activity of jiadifenolide on neuronal precursor cells derived from human induced pluripotent stem cells. Biochem. Biophys. Res. Commun. 2016 470:798-803 PubMed ID: 26809091 DOI: 10.1016/j.bbrc.2016.01.092

9660 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Improved Survival and Initiation of Differentiation of Human Induced Pluripotent Stem Cells to Hepatocyte-Like Cells upon Culture in William's E Medium followed by Hepatocyte Differentiation Inducer Treatment. PLoS ONE 2016 11:e0153435 PubMed ID: 27073925 DOI: 10.1371/journal.pone.0153435

9698 Horiguchi I, Sakai Y. Serum replacement with albumin-associated lipids prevents excess aggregation and enhances growth of induced pluripotent stem cells in suspension culture. Biotechnol. Prog. 2016 32:1009-16 PubMed ID: 27193385 DOI: 10.1002/btpr.2301

9756 Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H. In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations. Mol Brain 2016 9:70 PubMed ID: 27431206 DOI: 10.1186/s13041-016-0246-y

9794 Shimba K, Iida S, Kotani K, Jimbo Y. Cell-cycle-dependent Ca2+ transients in human induced pluripotent stem cells revealed by a simultaneous imaging of cell nuclei and intracellular Ca2+ level. Integr Biol (Camb) 2016 8:985-990 PubMed ID: 27713967 DOI: 10.1039/c6ib00074f

9800 Seno A, Kasai T, Ikeda M, Vaidyanath A, Masuda J, Mizutani A, Murakami H, Ishikawa T, Seno M. Characterization of Gene Expression Patterns among Artificially Developed Cancer Stem Cells Using Spherical Self-Organizing Map. Cancer Inform 2016 15:163-78 PubMed ID: 27559294 DOI: 10.4137/CIN.S39839

9838 Tomotsune D, Hirashima K, Fujii M, Yue F, Matsumoto K, Takizawa-Shirasawa S, Yokoyama T, Sasaki K. Enrichment of Pluripotent Stem Cell-Derived Hepatocyte-Like Cells by Ammonia Treatment. PLoS ONE 2016 11:e0162693 PubMed ID: 27632182 DOI: 10.1371/journal.pone.0162693

9853 Imamura T, Fujita K, Tagawa K, Ikura T, Chen X, Homma H, Tamura T, Mao Y, Taniguchi JB, Motoki K, Nakabayashi M, Ito N, Yamada K, Tomii K, Okano H, Kaye J, Finkbeiner S, Okazawa H. Identification of hepta-histidine as a candidate drug for Huntington's disease by in silico-in vitro- in vivo-integrated screens of chemical libraries. Sci Rep 2016 6:33861 PubMed ID: 27653664 DOI: 10.1038/srep33861

10851 Hayashi K, Ochiai-Shino H, Shiga T, Onodera S, Saito A, Shibahara T, Azuma T. Transplantation of human-induced pluripotent stem cells carried by self-assembling peptide nanofiber hydrogel improves bone regeneration in rat calvarial bone defects BDJ Open 2016 2:15007 PubMed ID: 29607061 DOI: 10.1038/bdjopen.2015.7

10891 Human iPS cell derived neural cell sheets exhibit mature neural and extendable scaffold functions and promote recovery in injured mouse spinal cords J Stem Cell Res Med 2016 1: 41-47 DOI: 10.15761/JSCRM.1000107

5758 Ashida T, Sakai S1, Taya M1. Propagation of human iPS cells in alginate-based microcapsules prepared using reactions catalyzed by horseradish peroxidase and catalase. Artif Cells Nanomed Biotechnol. 2016 44(6):1406-9 PubMed ID: 26148179 DOI: 10.3109/21691401.2015.1029631

5759 Takayama Y, Kida YS. In Vitro Reconstruction of Neuronal Networks Derived from Human iPS Cells Using Microfabricated Devices. PLoS One 2016 11(2):e0148559 PubMed ID: 26848955 DOI: 10.1371/journal.pone.0148559

13997 Matsumoto R, Shimizu K, Nagashima T, Tanaka H, Mizuno M, Kikkawa F, Hori M, Honda H. Plasma-activated medium selectively eliminates undifferentiated human induced pluripotent stem cells Regen Ther 2016 5:55-63 PubMed ID: 31245502 DOI: 10.1016/j.reth.2016.07.001

14189 Ryuhei Hayashi, Ryuhei Hayashi, Yuki Ishikawa, Ryosuke Katori, Yuki Taniwaki, Motokazu Tsujikawa, Andrew J. Quantock, Kohji Nishida Fabrication of a Corneal Epithelial Cell Sheet from Human Pluripotent Stem Cells by a Method Based on Spontaneous Ocular Cell Differentiation Protocol Exchange 2016 DOI: 10.1038/protex.2016.009

7204 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. Involvement of the Wnt signaling pathway in feeder-free culture of human induced pluripotent stem cells. Mol Med Rep 2015 12:6797-800 PubMed ID: 26398905 DOI: 10.3892/mmr.2015.4314

7223 Arai Y, Hayakawa K, Arai D, Ito R, Iwasaki Y, Saito K, Akutsu K, Takatori S, Ishii R, Hayashi R, Izumi S, Sugino N, Kondo F, Horie M, Nakazawa H, Makino T, Hirosawa M, Shiota K, Ohgane J. Putative Epimutagens in Maternal Peripheral and Cord Blood Samples Identified Using Human Induced Pluripotent Stem Cells. Biomed Res Int 2015 2015:876047 PubMed ID: 26339649 DOI: 10.1155/2015/876047

7271 Fujiwara N, Shimizu J, Takai K, Arimitsu N, Ueda Y, Wakisaka S, Suzuki T, Suzuki N. Cellular and molecular mechanisms of the restoration of human APP transgenic mouse cognitive dysfunction after transplant of human iPS cell-derived neural cells. Exp. Neurol. 2015 271:423-31 PubMed ID: 26196079 DOI: 10.1016/j.expneurol.2015.07.008

7364 Arai Y, Yamamoto T, Minamikawa T, Takamatsu T, Nagai T. Spectral fingerprinting of individual cells visualized by cavity-reflection-enhanced light-absorption microscopy. PLoS ONE 2015 10:e0125733 PubMed ID: 25950513 DOI: 10.1371/journal.pone.0125733

7482 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. An Optimal Medium Supplementation Regimen for Initiation of Hepatocyte Differentiation in Human Induced Pluripotent Stem Cells. J. Cell. Biochem. 2015 116:1479-89 PubMed ID: 25683148 DOI: 10.1002/jcb.25139

7495 Kato H, Ochiai-Shino H, Onodera S, Saito A, Shibahara T, Azuma T. Promoting effect of 1,25(OH)2 vitamin D3 in osteogenic differentiation from induced pluripotent stem cells to osteocyte-like cells. Open Biol 2015 5:140201 PubMed ID: 25652541 DOI: 10.1098/rsob.140201

7521 Binata Joddar, Chieko Nishioka, Eiki Takahashi, Yoshihiro Ito Chemically fixed autologous feeder cell-derived niche for human induced pluripotent stem cell culture. J Mater Chem B. 2015 3:2301-2307 PubMed ID: 32262060 DOI: 10.1039/C4TB01635A

7542 M Iinuma, T Umehara, N Arimitsu, J Shimizu, H Misawa, K Takai, N Fujiwara, A Fujii, Y Ueda, S Wakisaka, T Suzuki, C Hirotsu, M Beppu, N Suzuki Induction of neural cells with spinal motoneuron phenotype from human iPS cells and the trans-plantation to totally transected spinal cords in mice. Inflammation and Regeneration 2015 35:154-163 DOI: 10.2492/inflammregen.35.154

7550 N Kuzumaki, M Narita δ-Opioids and Neurogenesis. Y. Xia (ed.), Neural Functions of the Delta-Opioid Receptor 2015 9:389-398 DOI: 10.1007/978-3-319-25495-1_9

7562 Takuya Kuroda, Satoshi Yasuda, Satoko Matsuyama a, Keiko Tano, Shinji Kusakawa, Yoshiki Sawa, Shin Kawamata, Yoji Sato Highly sensitive droplet digital PCR method for detection of residual undifferentiated cells in cardiomyocytes derived from human pluripotent stem cells. Regenerative Therapy 2015 2:17-23 PubMed ID: 31245455 DOI: 10.1016/j.reth.2015.08.001

5449 Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J. Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein. Stem Cell Reports 2015 4(5):811-20 PubMed ID: 25866158 DOI: 10.1016/j.stemcr.2015.02.016

5697 Ishikawa T, Kobayashi M, Yanagi S, Kato C, Takashima R, Kobayashi E, Hagiwara K, Ochiya T Human induced hepatic lineage-oriented stem cells: autonomous specification of human iPS cells toward hepatocyte-like cells without any exogenous differentiation factors. PLoS One 2015 10(4):e0123193 PubMed ID: 25875613 DOI: 10.1371/journal.pone.0123193

5729 Matsuura K, Kodama F, Sugiyama K, Shimizu T, Hagiwara N, Okano T. Elimination of remaining undifferentiated induced pluripotent stem cells in the process of human cardiac cell sheet fabrication using a methionine-free culture condition. Tissue Eng Part C Methods 2015 21(3):330-8 PubMed ID: 25245976 DOI: 10.1089/ten.TEC.2014.0198

5747 Kawamata S, Kanemura H, Sakai N, Takahashi M, Go MJ. Design of a Tumorigenicity Test for Induced Pluripotent Stem Cell (iPSC)-Derived Cell Products. J Clin Med 2015 4(1):159-71 PubMed ID: 26237025 DOI: 10.3390/jcm4010159

5749 Takenaka C, Miyajima H, Yoda Y, Imazato H, Yamamoto T, Gomi S, Ohshima Y, Kagawa K, Sasaki T, Kawamata S. Controlled Growth and the Maintenance of Human Pluripotent Stem Cells by Cultivation with Defined Medium on Extracellular Matrix-Coated Micropatterned Dishes. PLoS One 2015 10(6):e0129855 PubMed ID: 26115194 DOI: 10.1371/journal.pone.0129855

5751 Morita A, Soga K, Nakayama H, Ishida T, Kawanishi S, Sato EF. Neuronal differentiation of human iPS cells induced by baicalin via regulation of bHLH gene expression. Biochem Biophys Res Commun 2015 465(3):458-63 PubMed ID: 26277393 DOI: 10.1016/j.bbrc.2015.08.039

5752 Onuma Y, Higuchi K, Aiki Y, Shu Y, Asada M, Asashima M, Suzuki M, Imamura T, Ito Y. A stable chimeric fibroblast growth factor (FGF) can successfully replace basic FGF in human pluripotent stem cell culture. PLoS One 2015 10(4):e0118931 PubMed ID: 25850016 DOI: 10.1371/journal.pone.0118931

5753 Komatsu M, Konagaya S, Egawa EY, Iwata H. Maturation of human iPS cell-derived dopamine neuron precursors in alginate-Ca(2+) hydrogel. Biochim Biophys Acta 2015 1850(9):1669-75 PubMed ID: 25952075 DOI: 10.1016/j.bbagen.2015.04.011

5754 Cieślar-Pobuda A, Jain MV, Kratz G, Rzeszowska-Wolny J, Ghavami S, Wiechec E. The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells. Oncotarget 2015 6(30):29753-70 PubMed ID: 26337471 DOI: 10.18632/oncotarget.4995

5755 Konagaya S, Iwata H. Microencapsulation of dopamine neurons derived from human induced pluripotent stem cells. Biochim Biophys Acta 2015 1850(1):22-32 PubMed ID: 25281770 DOI: 10.1016/j.bbagen.2014.09.025

5756 Shimojima K, Okumura A, Hayashi M, Kondo T, Inoue H, Yamamoto T. CHCHD2 is down-regulated in neuronal cells differentiated from iPS cells derived from patients with lissencephaly. Genomics 2015 106(4):196-203 PubMed ID: 26188257 DOI: 10.1016/j.ygeno.2015.07.001

5757 Haraguchi Y, Matsuura K, Shimizu T, Yamato M, Okano T. Simple suspension culture system of human iPS cells maintaining their pluripotency for cardiac cell sheet engineering. J Tissue Eng Regen Med 2015 9(12):1363-75 PubMed ID: 23728860 DOI: 10.1002/term.1761

5794 Mitsui K, Ide K, Takayama A, Wada T, Irie R, Kosai K. Conditionally replicating adenovirus prevents pluripotent stem cell-derived teratoma by specifically eliminating undifferentiated cells. Mol Ther Methods Clin Dev 2015 2:15026 PubMed ID: 26269798 DOI: 10.1038/mtm.2015.26

5708 Daisuke Takahashi, Masato Sasaki, Kuniaki Nagamine, Keiichi Torimitsu, and Matsuhiko Nishizawa Electroporation of Adherent Cells by Direct Lamination of Hydrogel-based Microelectrode Substrates Chem. Lett 2014 43:444–446 DOI: 10.1246/cl.131083

5724 Ochiai-Shino H, Kato H, Sawada T, Onodera S, Saito A, Takato T, Shibahara T, Muramatsu T, Azuma T. A novel strategy for enrichment and isolation of osteoprogenitor cells from induced pluripotent stem cells based on surface marker combination. PLoS One. 2014 9(6):e99534 PubMed ID: 24911063 DOI: 10.1371/journal.pone.0099534

5725 Imaizumi K, Nishishita N, Muramatsu M, Yamamoto T, Takenaka C, Kawamata S, Kobayashi K, Nishikawa S, Akuta T. A simple and highly effective method for slow-freezing human pluripotent stem cells using dimethyl sulfoxide, hydroxyethyl starch and ethylene glycol. PLoS One 2014 9(2):e88696 PubMed ID: 24533137 DOI: 10.1371/journal.pone.0088696

5726 Kobayashi J, Yoshida M, Tarui S, Hirata M, Nagai Y, Kasahara S, Naruse K, Ito H, Sano S, Oh H. Directed differentiation of patient-specific induced pluripotent stem cells identifies the transcriptional repression and epigenetic modification of NKX2-5, HAND1, and NOTCH1 in hypoplastic left heart syndrome. PLoS One 2014 9(7):e102796 PubMed ID: 25050861 DOI: 10.1371/journal.pone.0102796

5727 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Sueishi M. Dual gene expression in embryoid bodies derived from human induced pluripotent stem cells using episomal vectors. Tissue Eng Part A 2014 20(23-24):3154-62 PubMed ID: 24980753 DOI: 10.1089/ten.TEA.2014.0132

5728 Tani H, Onuma Y, Ito Y, Torimura M. Long non-coding RNAs as surrogate indicators for chemical stress responses in human-induced pluripotent stem cells. PLoS One 2014 9(8):e106282 PubMed ID: 25171338 DOI: 10.1371/journal.pone.0106282

5730 Bamba Y, Shofuda T, Kanematsu D, Nonaka M, Yamasaki M, Okano H, Kanemura Y. Differentiation, polarization, and migration of human induced pluripotent stem cell-derived neural progenitor cells co-cultured with a human glial cell line with radial glial-like characteristics. Biochem Biophys Res Commun 2014 447(4):683-8 PubMed ID: 24755070 DOI: 10.1016/j.bbrc.2014.04.070

5731 Tateno H, Onuma Y, Ito Y. Live-cell imaging of human pluripotent stem cells by a novel lectin probe rBC2LCN. Methods Mol Biol 2014 1200:313-8 PubMed ID: 25117245 DOI: 10.1007/978-1-4939-1292-6_26

5732 Tokunaga K, Saitoh N, Goldberg IG, Sakamoto C, Yasuda Y, Yoshida Y, Yamanaka S, Nakao M. Computational image analysis of colony and nuclear morphology to evaluate human induced pluripotent stem cells. Sci Rep 2014 4:6996 PubMed ID: 25385348 DOI: 10.1038/srep06996

5733 Ohnuma K, Fujiki A, Yanagihara K, Tachikawa S, Hayashi Y, Ito Y, Onuma Y, Chan T, Michiue T, Furue MK, Asashima M Enzyme-free passage of human pluripotent stem cells by controlling divalent cations. Sci Rep 2014 4:4646 PubMed ID: 24721898 DOI: 10.1038/srep04646

5734 Tateno H, Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J. A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells. Sci Rep 2014 4:4069 PubMed ID: 24518842 DOI: 10.1038/srep04069

5735 Yamada R, Hattori K, Tachikawa S, Tagaya M, Sasaki T, Sugiura S, Kanamori T, Ohnuma K. Control of adhesion of human induced pluripotent stem cells to plasma-patterned polydimethylsiloxane coated with vitronectin and γ-globulin. J Biosci Bioeng 2014 118(3):315-22 PubMed ID: 24656306 DOI: 10.1016/j.jbiosc.2014.02.009

5736 Kowno M et al Prohibitin 2 regulates the proliferation and lineage-specific differentiation of mouse embryonic stem cells in mitochondria. PLoS One 2014 9(4):e81552 PubMed ID: 24709813 DOI: 10.1371/journal.pone.0081552

5737 Ishizuka T, Goshima H, Ozawa A, Watanabe Y. Involvement of β-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells. Eur J Pharmacol 2014 740:28-34 PubMed ID: 25014757 DOI: 10.1016/j.ejphar.2014.06.056

5738 Kanemura H, Go MJ, Shikamura M, Nishishita N, Sakai N, Kamao H, Mandai M, Morinaga C, Takahashi M, Kawamata S. Tumorigenicity studies of induced pluripotent stem cell (iPSC)-derived retinal pigment epithelium (RPE) for the treatment of age-related macular degeneration. PLoS One 2014 9(1):e85336 PubMed ID: 24454843 DOI: 10.1371/journal.pone.0085336

5739 Yoshimitsu R, Hattori K, Sugiura S, Kondo Y, Yamada R, Tachikawa S, Satoh T, Kurisaki A, Ohnuma K, Asashima M, Kanamori T. Microfluidic perfusion culture of human induced pluripotent stem cells under fully defined culture conditions. Biotechnol Bioeng 2014 111(5):937-47 PubMed ID: 24222619 DOI: 10.1002/bit.25150

5740 Horiguchi A, Yazaki K, Aoyagi M, Ohnuki Y, Kurosawa H. Effective Rho-associated protein kinase inhibitor treatment to dissociate human iPS cells for suspension culture to form embryoid body-like cell aggregates. J Biosci Bioeng 2014 118(5):588-92 PubMed ID: 24856590 DOI: 10.1016/j.jbiosc.2014.04.008

5741 Tano K, Yasuda S, Kuroda T, Saito H, Umezawa A, Sato Y. A novel in vitro method for detecting undifferentiated human pluripotent stem cells as impurities in cell therapy products using a highly efficient culture system. PLoS One 2014 9(10):e110496 PubMed ID: 25347300 DOI: 10.1371/journal.pone.0110496

5742 Higuchi Y, Kawai K, Yamamoto M, Kuronuma M, Ando Y, Katano I, Nakamura M, Suemizu H. Novel enhanced green fluorescent protein-expressing NOG mouse for analyzing the microenvironment of xenograft tissues. Exp Anim 2014 63(1):55-62 PubMed ID: 24521863 DOI: 10.1538/expanim.63.55

5743 Kamada M, Mitsui Y, Kumazaki T, Kawahara Y, Matsuo T, Takahashi T. Tumorigenic risk of human induced pluripotent stem cell explants cultured on mouse SNL76/7 feeder cells. Biochem Biophys Res Commun 2014 453(3):668-73 PubMed ID: 25305485 DOI: 10.1016/j.bbrc.2014.10.009

5744 Kuroda T, Yasuda S, Sato Y. In vitro detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human induced pluripotent stem cells. Methods Mol Biol 2014 1210:183-92 PubMed ID: 25173169 DOI: 10.1007/978-1-4939-1435-7_14

5745 Luo L, Kawakatsu M, Guo CW, Urata Y, Huang WJ, Ali H, Doi H, Kitajima Y, Tanaka T, Goto S, Ono Y, Xin HB, Hamano K, Li TS. Effects of antioxidants on the quality and genomic stability of induced pluripotent stem cells. Sci Rep 2014 4:3779 PubMed ID: 24445363 DOI: 10.1038/srep03779

5746 Taguchi A, Kaku Y, Ohmori T, Sharmin S, Ogawa M, Sasaki H, Nishinakamura R. Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. Cell Stem Cell 2014 14(1):53-67 PubMed ID: 24332837 DOI: 10.1016/j.stem.2013.11.010

5748 Tsugata T1, Nikoh N, Kin T, Saitoh I, Noguchi Y, Ueki H, Watanabe M, James Shapiro AM, Noguchi H. Potential Factors for the Differentiation of ESCs/iPSCs Into Insulin-Producing Cells. Cell Med 2014 7(2):83-93 PubMed ID: 26858897 DOI: 10.3727/215517914X685178

13757 Ishihara Y, Tsuno S, Kuwamoto S, Yamashita T, Endo Y, Hasegawa J, Miura N. Hsa-miR-520d converts fibroblasts into CD105+ populations Drugs R D 2014 14(4):253-64. PubMed ID: 25303886 DOI: 10.1007/s40268-014-0064-6

15918 Lee JK, Jin HK, Park MH, Kim BR, Lee PH, Nakauchi H, Carter JE, He X, Schuchman EH, Bae JS. Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease J Exp Med 2014 211(8):1551-70 PubMed ID: 25049335 DOI: 10.1084/jem.20132451

16004 Ryotaro Yamada, Koji Hattori, Motohiro Tagaya, Toru Sasaki, Daisuke Miyamoto, Kohji Nakazawa, Shinji Sugiura, Toshiyuki Kanamori, Kiyoshi Ohnuma Plasma-Patterned Polydimethylsiloxane Surface With Single-Step Coating with a Mixture of Vitronectin and Albumin Enables the Formation of Small Discs and Spheroids of Human Induced Pluripotent Stem Cells Plasma Medicine 2014 4:165-176 DOI: 10.1615/plasmamed.2014012077

5707 Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T. Activin A is essential for Feeder-free culture of human induced pluripotent stem cells. J Cell Biochem 2013 114(3):584-8 PubMed ID: 22991093 DOI: 10.1002/jcb.24395

5709 Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T. Survival of primary human hepatocytes and death of induced pluripotent stem cells in media lacking glucose and arginine. PLoS One 2013 8(8):e71897 PubMed ID: 23967260 DOI: 10.1371/journal.pone.0071897

5710 Fujiwara N, Shimizu J, Takai K, Arimitsu N, Saito A, Kono T, Umehara T, Ueda Y, Wakisaka S, Suzuki T, Suzuki N. Restoration of spatial memory dysfunction of human APP transgenic mice by transplantation of neuronal precursors derived from human iPS cells. Neurosci Lett 2013 557 Pt B:129-34 PubMed ID: 24466594

5711 Saito A, Ochiai H, Okada S, Miyata N, Azuma T. Suppression of Lefty expression in induced pluripotent cancer cells. FASEB J 2013 27(6):2165-74 PubMed ID: 23407711 DOI: 10.1096/fj.12-221432

5712 Fukusumi H, Shofuda T, Kanematsu D, Yamamoto A, Suemizu H, Nakamura M, Yamasaki M, Ohgushi M, Sasai Y, Kanemura Y. Feeder-free generation and long-term culture of human induced pluripotent stem cells using pericellular matrix of decidua derived mesenchymal cells. PLoS One 2013 8(1):e55226 PubMed ID: 23383118 DOI: 10.1371/journal.pone.0055226

5713 Shofuda T, Fukusumi H, Kanematsu D, Yamamoto A, Yamasaki M, Arita N, Kanemura Y. A method for efficiently generating neurospheres from human-induced pluripotent stem cells using microsphere arrays. Neuroreport 2013 24(2):84-90 PubMed ID: 23238165 DOI: 10.1097/WNR.0b013e32835cb677

5714 Onuma Y, Tateno H, Hirabayashi J, Ito Y, Asashima M. rBC2LCN, a new probe for live cell imaging of human pluripotent stem cells. Biochem Biophys Res Commun 2013 431(3):524-9 PubMed ID: 23321312 DOI: 10.1016/j.bbrc.2013.01.025

5716 Donai K, Kuroda K, Guo Y, So KH, Sone H, Kobayashi M, Nishimori K, Fukuda T. Establishment of a reporter system to monitor silencing status in induced pluripotent stem cell lines. Anal Biochem 2013 443(1):104-12 PubMed ID: 23973628 DOI: 10.1016/j.ab.2013.08.014

5717 Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori MX, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S. A human Dravet syndrome model from patient induced pluripotent stem cells. Mol Brain 2013 6:19 PubMed ID: 23639079 DOI: 10.1186/1756-6606-6-19

5718 Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K, Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y, Nakanishi M, Ohnuma K, Chan T, Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J. Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN. Stem Cells Transl Med 2013 2(4):265-73 PubMed ID: 23526252 DOI: 10.5966/sctm.2012-0154

5719 Toshiaki Ishizuka Hazuki Goshima Ayako Ozawa Yasuhiro Watanabe Stimulation ofα1-adrenoceptor or angiotensin type 1 receptorenhances DNA synthesis in human-induced pluripotent stemcells via Gq-coupled receptor-dependent signaling pathways European Journal of Pharmacology 2013 714:202-209 PubMed ID: 23792040 DOI: 10.1016/j.ejphar.2013.06.003

5720 Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T. Single-step protocol for the differentiation of human-induced pluripotent stem cells into hepatic progenitor-like cells. Biomed Rep 2013 1(1):18-22. PubMed ID: 24648886 DOI: 10.3892/br.2012.2

5722 Guo CW, Kawakatsu M, Idemitsu M, Urata Y, Goto S, Ono Y, Hamano K, Li TS. Culture under low physiological oxygen conditions improves the stemness and quality of induced pluripotent stem cells. J Cell Physiol 2013 228(11):2159-66 PubMed ID: 23589166 DOI: 10.1002/jcp.24389

5723 Inagaki E, Hatou S, Yoshida S, Miyashita H, Tsubota K, Shimmura S. Expression and distribution of claudin subtypes in human corneal endothelium. Invest Ophthalmol Vis Sci 2013 54(12):7258-65 PubMed ID: 24114540 DOI: 10.1167/iovs.13-12022

13655 Ohta S, Imaizumi Y, Akamatsu W, Okano H, Kawakami Y. Generation of human melanocytes from induced pluripotent stem cells Methods Mol Biol 2013 989:193-215 PubMed ID: 23483397 DOI: 10.1007/978-1-62703-330-5_16

5702 Hayashi R, Ishikawa Y, Ito M, Kageyama T, Takashiba K, Fujioka T, Tsujikawa M, Miyoshi H, Yamato M, Nakamura Y, Nishida K. Generation of corneal epithelial cells from induced pluripotent stem cells derived from human dermal fibroblast and corneal limbal epithelium. PLoS One 2012 7(9):e45435 PubMed ID: 23029008 DOI: 10.1371/journal.pone.0045435

5703 Hasehira K, Tateno H, Onuma Y, Ito Y, Asashima M, Hirabayashi J. Structural and quantitative evidence for dynamic glycome shift on production of induced pluripotent stem cells. Mol Cell Proteomics 2012 11(12):1913-23 PubMed ID: 23023295 DOI: 10.1074/mcp.M112.020586

5704 Kuroda T, Yasuda S, Kusakawa S, Hirata N, Kanda Y, Suzuki K, Takahashi M, Nishikawa S, Kawamata S, Sato Y. Highly sensitive in vitro methods for detection of residual undifferentiated cells in retinal pigment epithelial cells derived from human iPS cells. PLoS One 2012 7(5):e37342 PubMed ID: 22615985 DOI: 10.1371/journal.pone.0037342

5706 Otsuji TG, Kurose Y, Suemori H, Tada M, Nakatsuji N. Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes. PLoS One 2012 7(9):e45010 PubMed ID: 22984602 DOI: 10.1371/journal.pone.0045010

5721 Shofuda T, Kanematsu D, Fukusumi H, Yamamoto A, Bamba Y, Yoshitatsu S, Suemizu H, Nakamura M, Sugimoto Y, Furue MK, Kohara A, Akamatsu W, Okada Y, Okano H, Yamasaki M, Kanemura Y. Human Decidua-Derived Mesenchymal Cells Are a Promising Source for the Generation and Cell Banking of Human Induced Pluripotent Stem Cells. Cell Med 2012 4(3):125-47 PubMed ID: 26858858 DOI: 10.3727/215517912X658918

7771 Ogawa S, Tokumoto Y, Miyake J, Nagamune T. Induction of oligodendrocyte differentiation from adult human fibroblast-derived induced pluripotent stem cells. In Vitro Cell. Dev. Biol. Anim. 2011 47:464-9 PubMed ID: 21695581 DOI: 10.1007/s11626-011-9435-2

5698 Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T. Activin A maintains pluripotency markers and proliferative potential of human induced pluripotent stem cells. Exp Ther Med 2011 2(3):405-408 PubMed ID: 22977517 DOI: 10.3892/etm.2011.219

5750 Kumazaki T, Kurata S, Matsuo T, Mitsui Y, Takahashi T. Establishment of human induced pluripotent stem cell lines from normal fibroblast TIG-1. Hum Cell 2011 24(2):96-103 PubMed ID: 21562774 DOI: 10.1007/s13577-011-0016-1

5699 Nishi M, Akutsu H, Masui S, Kondo A, Nagashima Y, Kimura H, Perrem K, Shigeri Y, Toyoda M, Okayama A, Hirano H, Umezawa A, Yamamoto N, Lee SW, Ryo A. A distinct role for Pin1 in the induction and maintenance of pluripotency. J Biol Chem 2011 286(13):11593-603 PubMed ID: 21296877 DOI: 10.1074/jbc.M110.187989

5700 Yoshizaki S, Nishi M, Kondo A, Kojima Y, Yamamoto N, Ryo A. Vaccination with Human Induced Pluripotent Stem Cells Creates an Antigen-Specific Immune Response Against HIV-1 gp160. Front Microbiol 2011 2:27 PubMed ID: 21687419 DOI: 10.3389/fmicb.2011.00004