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Cell No. : Cell Name
RCB0098 : A549  update : 2024/03/08
CommentHuman cell line derived from lung cancer.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Abe, Shin-ichiro
Originator Giard, D. J.
Year of deposit 1986
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Tissue lung
Disease name adenocarcinoma
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0023
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP, G6PD
Chromosome mode 59-64(50) : 59(3),60(2),61(8),62(21),63(14),64(2)
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 339


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Reference
4609  Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G.  A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells.  Int J Cancer  1976  17(1):62-70  PubMed ID: 175022   DOI: 10.1002/ijc.2910170110

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User's Publication
21542  Morihiro K, Morita S, Harada N, Baba M, Yum J, Naito M, Miyata K, Nagae G, Okamoto A.  RNA Oncological Therapeutics: Intracellular Hairpin RNA Assembly Enables MicroRNA-Triggered Anticancer Functionality.  J Am Chem Soc  2024    PubMed ID: 38170469   DOI: 10.1021/jacs.3c09524
21618  Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T.  PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells.  J Biol Chem  2024  300(1):105584  PubMed ID: 38141761   DOI: 10.1016/j.jbc.2023.105584
17622  Maruyama S, Sakabe N, Ito C, Shimoyama Y, Sato S, Ikeda K.  Effect of Specimen Processing Technique on Cell Detection and Classification by Artificial Intelligence  Am J Clin Pathol  2023  aqac178  PubMed ID: 36933198   DOI: 10.1093/ajcp/aqac178
17769  Primadharsini PP, Nagashima S, Tanaka T, Jirintai S, Takahashi M, Murata K, Okamoto H.  Development and Characterization of Efficient Cell Culture Systems for Genotype 1 Hepatitis E Virus and Its Infectious cDNA Clone  Viruses  2023  15(4):845  PubMed ID: 37112827   DOI: 10.3390/v15040845
17785  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Oboshi W, Komene T, Yamaguchi Y, Sato S, Nagata K.  Relationship between a deep learning model and liquid-based cytological processing techniques  Cytopathology  2023  Apr 13  PubMed ID: 37051774   DOI: 10.1111/cyt.13235
17792  Ryo Doge, Yuki Nishino, Akiko Saito  Fluorinated Derivatives of Digalloyl-Flavan-3-ol Induce Autophagic Cell Death by Forming Granular Aggregates Containing Mitochondria  BioChem  2023  3:61-77    DOI: 10.3390/biochem3020005
17808  Sato Y, Yoshino H, Sato K, Kashiwakura I, Tsuruga E.  DAP3-mediated cell cycle regulation and its association with radioresistance in human lung adenocarcinoma cell lines  J Radiat Res  2023  rrad016  PubMed ID: 37023702   DOI: 10.1093/jrr/rrad016
17814  Tamai M, Taba S, Mise T, Yamashita M, Ishikawa H, Shintake T.  Ethanol vapor inhalation treatment inhibits lethal respiratory viral infection with Influenza A  J Infect Dis  2023  jiad089  PubMed ID: 37101418   DOI: 10.1093/infdis/jiad089
17816  Satoshi Nozaki, Yuka Nakatani, Aya Mawatari, William Ewan Hume, Hisashi Doi, Yasuyoshi Watanabe  In vitro evaluation of (S)-2-amino-3-[3-(2-18F-fluoroethoxy)-4-iodophenyl]-2-methylpropanoic acid (18F-FIMP) as a positron emission tomography probe for imaging amino acid transporters  EJNMMI Research  2023  13    DOI: 10.1186/s13550-023-00988-1
19918  Horie M, Fujita K, Endoh S, Sugino S, Maru J, Moriyama A, Ogura I.  Contaminant microorganisms in the in vitro evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation  Toxicol Mech Methods  2023  33(9):741-754  PubMed ID: 37496379   DOI: 10.1080/15376516.2023.2238061
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
19976  Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK.  Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer  J Med Chem  2023  Dec 17  PubMed ID: 38105611   DOI: 10.1021/acs.jmedchem.3c01493
21065  Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A.  Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.  J Am Chem Soc  2023  145(1):135-142  PubMed ID: 36538570   DOI: 10.1021/jacs.2c08974
21080  Miura K, Koyanagi-Aoi M, Maniwa Y, Aoi T.  Chorioallantoic membrane assay revealed the role of TIPARP (2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible poly (ADP-ribose) polymerase) in lung adenocarcinoma-induced angiogenesis.  Cancer Cell Int  2023  23(1):34  PubMed ID: 36841751   DOI: 10.1186/s12935-023-02870-5
21168  Yang J, Liu L, Oda Y, Wada K, Ago M, Matsuda S, Hattori M, Goto T, Kawashima Y, Matsuzaki Y, Taketani T.  Highly-purified rapidly expanding clones, RECs, are superior for functional-mitochondrial transfer.  Stem Cell Res Ther  2023  14(1):40  PubMed ID: 36927781   DOI: 10.1186/s13287-023-03274-y
21185  Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S.  Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.  Drug Deliv  2023  30(1):2191891  PubMed ID: 36964673   DOI: 10.1080/10717544.2023.2191891
21259  Takata J, Kiura K, Nakasuka T, Hirabae A, Arimoto-Kobayashi S.  Chemo-preventive effects and antitumorigenic mechanisms of beer and nonalcoholic beer toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) - induced lung tumorigenesis in A/J mice.  Genes Environ  2023  45(1):19  PubMed ID: 37280663   DOI: 10.1186/s41021-023-00276-3
21379  Hata M, Ueno J, Hitomi Y, Kodera M.  Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.  ACS Omega  2023  8(31):28690-28701  PubMed ID: 37576680   DOI: 10.1021/acsomega.3c03387
21380  Tagawa Y, Sakagami H, Tanuma SI, Amano S, Uota S, Bandow K, Tomomura M, Uesawa Y, Takao K, Sugita Y, Yamamoto N, Sakashita H, Nakakaji R, Koizumi T, Mitsudo K, Tohnai I.  Potentiation of Anticancer Activity of G2/M Blockers by Mild Hyperthermia.  Anticancer Res  2023  43(8):3429-3439  PubMed ID: 37500171   DOI: 10.21873/anticanres.16518
21514  Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N.  Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma.  Nat Commun  2023  14(1):8095  PubMed ID: 38092728   DOI: 10.1038/s41467-023-43630-3
21526  Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H.  Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells.  Eur J Pharmacol  2023  960:176156  PubMed ID: 38059445   DOI: 10.1016/j.ejphar.2023.176156
21547  Autsavapromporn N, Kobayashi A, Liu C, Duangya A, Oikawa M, Tengku Ahmad TA, Konishi T.  Primary and Secondary Bystander Effects of Proton Microbeam Irradiation on Human Lung Cancer Cells under Hypoxic Conditions.  Biology (Basel)  2023  12(12)  PubMed ID: 38132311   DOI: 10.3390/biology12121485
17494  Maeda A, Fujimura T, Hirakawa N, Baba K, Kawamoto S.  A Methoxyflavanone from Perilla frutescens Induces Cellular Senescence in A549 Human Lung Adenocarcinoma Cells but Not in Normal Human Bronchial Epithelial Cells  Biol Pharm Bull  2022  45(10):1581-1584  PubMed ID: 35979561   DOI: 10.1248/bpb.b22-00310
17595  Maki M, JeongMin H, Nakagawa T, Kawai H, Sakamoto N, Sato Y, Noguchi M.  Aberrant OCIAD2 demethylation in lung adenocarcinoma is associated with outcome  Pathol Int  2022  72(10):496-505  PubMed ID: 35920378   DOI: 10.1111/pin.13262
17647  Tamari S, Menju T, Toyazaki T, Miyamoto H, Chiba N, Noguchi M, Ishikawa H, Miyata R, Kayawake H, Tanaka S, Yamada Y, Yutaka Y, Nakajima D, Ohsumi A, Hamaji M, Date H.  Nrf2/p‑Fyn/ABCB1 axis accompanied by p‑Fyn nuclear accumulation plays pivotal roles in vinorelbine resistance in non‑small cell lung cancer  Oncol Rep  2022  48(4):171  PubMed ID: 35959810   DOI: 10.3892/or.2022.8386
18224  Sadahiro Y, Hitora Y, Kimura I, Hitora-Imamura N, Onodera R, Motoyama K, Tsukamoto S.  Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53  Chem Res Toxicol  2022  35(9):1598-1603  PubMed ID: 36027604   DOI: 10.1021/acs.chemrestox.2c00202
13435  Funato N, Yanagisawa H.  TBX1 targets the miR-200-ZEB2 axis to induce epithelial differentiation and inhibit stem cell properties  Sci Rep  2022  12(1):20188  PubMed ID: 36418889   DOI: 10.1038/s41598-022-24604-9
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2022  e1485  PubMed ID: 34173723   DOI: 10.1002/cnr2.1485
20391  Fardous J, Omoso Y, Yoshida K, Ono F, Patwary MKA, Ijima H.  Gel-in-water nanodispersion for potential application in intravenous delivery of anticancer drugs.  J Biosci Bioeng  2022    PubMed ID: 34789413   DOI: 10.1016/j.jbiosc.2021.10.001
20408  Ikeda K, Oboshi W, Hashimoto Y, Komene T, Yamaguchi Y, Sato S, Maruyama S, Furukawa N, Sakabe N, Nagata K.  Characterizing the Effect of Processing Technique and Solution Type on Cytomorphology Using Liquid-Based Cytology.  Acta Cytol  2022  1-6  PubMed ID: 34644702   DOI: 10.1159/000519335
20410  Autsavapromporn N, Kobayashi A, Liu C, Jaikang C, Ahmad TAT, Oikawa M, Konishi T.  Hypoxia and Proton microbeam: Role of Gap Junction Intercellular Communication in Inducing Bystander Responses on Human Lung Cancer Cells and Normal Cells.  Radiat Res  2022    PubMed ID: 34634126   DOI: 10.1667/RADE-21-00112.1
20486  Horibe S, Ishikawa K, Nakada K, Wake M, Takeda N, Tanaka T, Kawauchi S, Sasaki N, Rikitake Y.  Mitochondrial DNA mutations are involved in the acquisition of cisplatin resistance in human lung cancer A549 cells.  Oncol Rep  2022  47(2)  PubMed ID: 34935060   DOI: 10.3892/or.2021.8243
16353  Tsujiya Y, Hasegawa A, Yamamori M, Okamura N.  Troglitazone-Induced Autophagic Cytotoxicity in Lung Adenocarcinoma Cell Lines  Biol Pharm Bull  2022  45(3):276-283  PubMed ID: 35228393   DOI: 10.1248/bpb.b21-00785
20590  Hagimori M, Hara F, Mizuyama N, Fujino T, Saji H, Mukai T.  High-Affinity Ratiometric Fluorescence Probe Based on 6-Amino-2,2'-Bipyridine Scaffold for Endogenous Zn2+ and Its Application to Living Cells.  Molecules  2022  27(4)  PubMed ID: 35209077   DOI: 10.3390/molecules27041287
20595  Matsushige T, Sakabe T, Umekita Y.  Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line.  Yonago Acta Med  2022  65(1):44-52  PubMed ID: 35221759   DOI: 10.33160/yam.2022.02.006
20613  Shimmyo N, Furuhata M, Yamada M, Utoh R, Seki M.  Process simplification and structure design of parallelized microslit isolator for physical property-based capture of tumor cells.  Analyst  2022    PubMed ID: 35297918   DOI: 10.1039/d2an00052k
20674  Ito K, Nagata K, Ohta S, Matsuda Y, Ukai T, Yasuda I, Ota A, Kobayashi R, Kabata M, Sankoda N, Maeda T, Woltjen K, Yang L, Maruyama R, Katayama R, Yamamoto T, Yamada Y.  The oncogene-dependent resistance to reprogramming unveils cancer therapeutic targets.  Cell Rep  2022  39(4):110721  PubMed ID: 35476996   DOI: 10.1016/j.celrep.2022.110721
20684  Fujimoto M, Higashiyama R, Yasui H, Yamashita K, Inanami O.  Preclinical studies for improving radiosensitivity of non-small cell lung cancer cell lines by combining glutaminase inhibition and senolysis.  Transl Oncol  2022  21:101431  PubMed ID: 35452996   DOI: 10.1016/j.tranon.2022.101431
16485  Toma T, Tateishi H, Kawakami K, Ali TFS, Kamo M, Monde K, Nakashima Y, Fujita M, Otsuka M.  Novel Inhibitor for Downstream Targeting of Transforming Growth Factor-β Signaling to Suppress Epithelial to Mesenchymal Transition and Cell Migration  Int J Mol Sci  2022  23(9):5047  PubMed ID: 35563439   DOI: 10.3390/ijms23095047
16496  Siswanto FM, Tamura A, Sakuma R, Imaoka S.  Yeast β-glucan Increases Etoposide Sensitivity in Lung Cancer Cell Line A549 by Suppressing Nuclear Factor Erythroid 2-Related Factor 2 via the Noncanonical Nuclear Factor Kappa B Pathway  Mol Pharmacol  2022  101(4):257-273  PubMed ID: 35193967   DOI: 10.1124/molpharm.121.000475
16710  Alaa N. Hassan, Tsugumasa Toma, Halilibrahim Ciftci, Tanima Biswas, Yurika Tahara, Mohamed O. Radwan, Hiroshi Tateishi, Mikako Fujita, Masami Otsuka  A vitamin D C/D ring-derived compound with cytotoxicity  Medicinal Chemistry Research  2022  1120-1125    DOI: 10.1007/s00044-021-02842-2
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20808  Riko Nakagawa, Hiroshi Tateishi, Mohamed O. Radwan, Takuma Chinen, Halilibrahim Ciftci, Kana Iwamaru, Nanami Baba, Yuna Tominaga, Ryoko Koga, Tsugumasa Toma, Jun-ichiro Inoue, Kazuo Umezawa, Mikako Fujita, Masami Otsuka  A New 1,2-Naphthoquinone Derivative with Anti-lung Cancer Activity  Chemical and Pharmaceutical Bulletin  2022  477-482  PubMed ID: 35786566   DOI: 10.1248/cpb.c21-01087
16959  Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, Mikako Fujita  Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells  Medicinal Chemistry Research  2022  31:1584-1593    DOI: 10.1007/s00044-022-02939-2
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937
20896  Ikeda K, Sakabe N, Maruyama S, Ito C, Shimoyama Y, Sato S, Nagata K.  Relationship between Liquid-Based Cytology Preservative Solutions and Artificial Intelligence: Liquid-Based Cytology Specimen Cell Detection Using YOLOv5 Deep Convolutional Neural Network.  Acta Cytol  2022  1-9  PubMed ID: 36067744   DOI: 10.1159/000526098
20912  Kotani N, Nakano T, Kuwahara R.  Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis.  J Biol Chem  2022  298(11):102500  PubMed ID: 36152751   DOI: 10.1016/j.jbc.2022.102500
20963  Takata J, Miyake N, Saiki Y, Tada M, Sasaki K, Kubo T, Kiura K, Arimoto-Kobayashi S.  Chemopreventive effects and anti-tumorigenic mechanisms of Actinidia arguta, known as sarunashi in Japan toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)- induced lung tumorigenesis in a/J mouse.  Genes Environ  2022  44(1):26  PubMed ID: 36494703   DOI: 10.1186/s41021-022-00255-0
12851  Kamo M, Ito M, Toma T, Gotoh H, Shimozono R, Nakagawa R, Koga R, Monde K, Tateishi H, Misumi S, Otsuka M, Fujita M.  Discovery of anti-cell migration activity of an anti-HIV heterocyclic compound by identification of its binding protein hnRNP M  Bioorg Chem  2021  107:104627  PubMed ID: 33476868   DOI: 10.1016/j.bioorg.2021.104627
13332  Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.  Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.  Oncol Rep  2021    PubMed ID: 33155667   DOI: 10.3892/or.2020.7839
20016  Matsumoto N, Ebihara M, Oishi S, Fujimoto Y, Okada T, Imamura T.  Histamine H1 receptor antagonists selectively kill cisplatin-resistant human cancer cells.  Sci Rep  2021  11(1):1492  PubMed ID: 33452347   DOI: 10.1038/s41598-021-81077-y
20076  Anam MB, Istiaq A, Kariya R, Kudo M, Ishtiyaq Ahmad SA, Ito N, Okada S, Ohta K.  Ribosome induces transdifferentiation of A549 and H-111-TC cancer cell lines.  Biochem Biophys Rep  2021  26:100946  PubMed ID: 33644423   DOI: 10.1016/j.bbrep.2021.100946
13718  Aida R, Hagiwara K, Okano K, Nakata K, Obata Y, Yamashita T, Yoshida K, Hagiwara H.  miR-34a-5p might have an important role for inducing apoptosis by down-regulation of SNAI1 in apigenin-treated lung cancer cells  Mol Biol Rep  2021  Mar 6  PubMed ID: 33675467   DOI: 10.1007/s11033-021-06255-7
13912  Yamamoto S, Nakanishi J.  Epidermal growth factor-gold nanoparticle conjugates-induced cellular responses: Effect of interfacial parameters between cell and nanoparticle  Anal Sci  2021  37(5):741-745  PubMed ID: 33390415   DOI: 10.2116/analsci.20SCP16
20145  Kiba Y, Oyama R, Misawa S, Tanikawa T, Kitamura M, Suzuki R.  Screening for inhibitory effects of crude drugs on furin-like enzymatic activities.  J Nat Med  2021    PubMed ID: 33928494   DOI: 10.1007/s11418-021-01519-9
20147  Kariya Y, Oyama M, Suzuki T, Kariya Y.  αvβ3 Integrin induces partial EMT independent of TGF-β signaling.  Commun Biol  2021  4(1):490  PubMed ID: 33883697   DOI: 10.1038/s42003-021-02003-6
14339  Sumitomo T, Nakata M, Nagase S, Takahara Y, Honda-Ogawa M, Mori Y, Akamatsu Y, Yamaguchi M, Okamoto S, Kawabata S.  GP96 Drives Exacerbation of Secondary Bacterial Pneumonia following Influenza A Virus Infection  mBio  2021  e0326920  PubMed ID: 34061598   DOI: 10.1128/mBio.03269-20
20205  Arimoto-Kobayashi S, Sasaki K, Hida R, Miyake N, Fujii N, Saiki Y, Daimaru K, Nakashima H, Kubo T, Kiura K.  Chemopreventive effects and anti-tumorigenic mechanisms of 2,6-dimethoxy-1,4-benzoquinone, a constituent of Vitis coignetiae Pulliat (crimson glory vine, known as yamabudo in Japan), toward 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J mice.  Food Chem Toxicol  2021  154:112319  PubMed ID: 34087405   DOI: 10.1016/j.fct.2021.112319
20278  Fukai R, Ogo N, Ichida T, Yamane M, Sawada JI, Miyoshi N, Murakami H, Asai A.  Design, synthesis, and evaluation of a novel prodrug, a S-trityl-l-cysteine derivative targeting kinesin spindle protein.  Eur J Med Chem  2021  215:113288  PubMed ID: 33640763   DOI: 10.1016/j.ejmech.2021.113288
15273  Tsukayama I, Mega T, Hojo N, Toda K, Kawakami Y, Takahashi Y, Suzuki-Yamamoto T.  Diosgenin suppresses COX-2 and mPGES-1 via GR and improves LPS-induced liver injury in mouse  Prostaglandins Other Lipid Mediat  2021  Jul 9  PubMed ID: 34252545   DOI: 10.1016/j.prostaglandins.2021.106580
15490  Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.  LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence  Transl Oncol  2021  14(11):101212  PubMed ID: 34461558   DOI: 10.1016/j.tranon.2021.101212
15504  Taguchi J, Shibata H, Kabata M, Kato M, Fukuda K, Tanaka A, Ohta S, Ukai T, Mitsunaga K, Yamada Y, Nagaoka SI, Yamazawa S, Ohnishi K, Woltjen K, Ushiku T, Ozawa M, Saitou M, Shinkai Y, Yamamoto T, Yamada Y.  DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency  Nat Commun  2021  12(1):5041  PubMed ID: 34413299   DOI: 10.1038/s41467-021-25249-4
20362  Sasaki M, Kishimoto M, Itakura Y, Tabata K, Intaruck K, Uemura K, Toba S, Sanaki T, Sato A, Hall WW, Orba Y, Sawa H.  Air-liquid interphase culture confers SARS-CoV-2 susceptibility to A549 alveolar epithelial cells.  Biochem Biophys Res Commun  2021  577:146-151  PubMed ID: 34517212   DOI: 10.1016/j.bbrc.2021.09.015
20363  Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Seino S, Sugai A, Yoshioka T, Okada M, Kitanaka C.  Lurasidone Sensitizes Cancer Cells to Osimertinib by Inducing Autophagy and Reduction of Survivin.  Anticancer Res  2021  41(9):4321-4331  PubMed ID: 34475052   DOI: 10.21873/anticanres.15237
20367  Kariya Y, Oyama M, Kariya Y, Hashimoto Y.  Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.  Biomolecules  2021  11(9)  PubMed ID: 34572536   DOI: 10.3390/biom11091323
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032   DOI: 10.1016/j.heliyon.2021.e08318
20423  Shindo Y, Arai W, Konno T, Kohno T, Kodera Y, Chiba H, Miyajima M, Sakuma Y, Watanabe A, Kojima T.  Effects of histone deacetylase inhibitors Tricostatin A and Quisinostat on tight junction proteins of human lung adenocarcinoma A549 cells and normal lung epithelial cells.  Histochem Cell Biol  2021  155(6):637-653  PubMed ID: 33974136   DOI: 10.1007/s00418-021-01966-1
15879  Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.  5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2  iScience  2021  24(10):103120  PubMed ID: 34541466   DOI: 10.1016/j.isci.2021.103120
15881  Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, de Figueiredo P, Sawa H, Kobayashi KS.  SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis  Nat Commun  2021  12(1):6602  PubMed ID: 34782627   DOI: 10.1038/s41467-021-26910-8
20510  Takasaka M, Kobayashi S, Usui Y, Haniu H, Tsuruoka S, Aoki K, Saito N.  Biokinetic Evaluation of Contrast Media Loaded Carbon Nanotubes Using a Radiographic Device.  Toxics  2021  9(12)  PubMed ID: 34941765   DOI: 10.3390/toxics9120331
16119  Sanoyama I, Sakurai Y, Ichinoe M, Hoshino A, Kesen Y, Kato T, Numata Y, Umezawa A, Jiang SX, Murakumo Y.  Increased expression of REV7 in small cell lung carcinomas and its association with tumor cell survival and proliferation  Pathol Int  2021  71(1):15-23  PubMed ID: 33112501   DOI: 10.1111/pin.13040
16128  Sato Y, Yoshino H, Kashiwakura I, Tsuruga E.  DAP3 Is Involved in Modulation of Cellular Radiation Response by RIG-I-Like Receptor Agonist in Human Lung Adenocarcinoma Cells  Int J Mol Sci  2021  22(1):420  PubMed ID: 33401559   DOI: 10.3390/ijms22010420
16219  Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto  Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma  Cancer Sci  2021  112(12):5114-5126  PubMed ID: 34628698   DOI: 10.1111/cas.15160
16225  M Sato, K Hirose, K Ichise, H Yoshino, T Harada, Y Hatayama, H Kawaguchi, M Tanaka, I Fujioka, Y Takai, M Aoki  Not Only Hypoxia- but Radiation-Induced Epithelial-Mesenchymal Transition Is Modulated by Hypoxia-Inducible Factor 1 in A549 Lung Cancer Cells  Folia Biol (Praha)  2021  67(2):62-69.  PubMed ID: 34624938  
16231  Onuma S, Manabe A, Yoshino Y, Matsunaga T, Asai T, Ikari A.  Upregulation of Chemoresistance by Mg 2+ Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells  Cells  2021  10(5):1179  PubMed ID: 34066059   DOI: 10.3390/cells10051179
16523  Takeru Yamazaki, Kohe Arima, Riku Kubota, Kiyoshi Sato, Hiroyoshi Kawakami  Preparation of Mitochondria‐ and Epigenetics‐Targeting Nanoparticles for Suppression of Cancer Metastasis  Particle & Particle Systems Characterization  2021  38:2100003    DOI: 10.1002/ppsc.202100003
17827  Hirofumi Kurita, Yoshie Minamijima, Kazunori Takashima  Characterization of intracellular reactive species production stimulated by cold atmospheric pressure plasma irradiation  Int. J. Plasma Environ. Sci. Technol  2020  14:e03003 (9pp)    DOI: 10.34343/ijpest.2020.14.e03003
6923  Nasako H, Akizuki R, Takashina Y, Ishikawa Y, Shinoda T, Shirouzu M, Asai T, Matsunaga T, Endo S, Ikari A.  Claudin-2 binding peptides, VPDSM and DSMKF, down-regulate claudin-2 expression and anticancer resistance in human lung adenocarcinoma A549 cells.  Biochim Biophys Acta Mol Cell Res.  2020  1867(4):118642  PubMed ID: 31923533   DOI: 10.1016/j.bbamcr.2019.118642
9729  Yasuhiro Takenouchi, Keisuke Kitakaze, Kazuhito Tsuboi, Yasuo Okamoto  Growth Differentiation Factor 15 Facilitates Lung Fibrosis by Activating Macrophages and Fibroblasts  Exp Cell Res  2020  391(2):112010  PubMed ID: 32305327   DOI: 10.1016/j.yexcr.2020.112010
9819  Keisuke Toda, Mai Ueyama, Shomu Tanaka, Izumi Tsukayama, Takuto Mega, Yuka Konoike, Asako Tamenobu, Februadi Bastian, Iria Akai, Hideyuki Ito, Yuki Kawakami, Yoshitaka Takahashi, Toshiko Suzuki-Yamamoto  Ellagitannins From Punica granatum Leaves Suppress Microsomal Prostaglandin E synthase-1 Expression and Induce Lung Cancer Cells to Undergo Apoptosis  Biosci Biotechnol Biochem  2020  84(4):757-763  PubMed ID: 31868102   DOI: 10.1080/09168451.2019.1706442
11986  Maezawa H, Indo HP, Usami N, Majima HJ, Ito H, Ohnishi K, Kobayashi K.  Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus.  J. Radiat. Res.  2020  61(2):237-242.  PubMed ID: 31904079   DOI: 10.1093/jrr/rrz098
12065  Tomizawa S, Tamori M, Tanaka A, Utsumi N, Sato H, Hatakeyama H, Hisaka A, Kohama T, Yamagata K, Honda T, Nakamura H, Murayama T.  Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2020    PubMed ID: 32112978   DOI: 10.1016/j.bbalip.2020.158675
12375  Morita S, Horii T, Kimura M, Hatada I.  Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform  Int J Mol Sci   2020  21(5):1574  PubMed ID: 32106616   DOI: 10.3390/ijms21051574
12376  Uddin M, Kawami M, Yumoto R, Takano M.  Effect of transforming growth factor-β1 on functional expression of monocarboxylate transporter 1 in alveolar epithelial A549 cells  Naunyn Schmiedebergs Arch Pharmacol  2020  393(5):889-896  PubMed ID: 31900520   DOI: 10.1007/s00210-019-01802-3
12607  Dukaew N, Konishi T, Chairatvit K, Autsavapromporn N, Soonthornchareonnon N, Wongnoppavich A.  Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair  Oncol Res  2020  28(2):161-175  PubMed ID: 31727206   DOI: 10.3727/096504019X15736439848765
12989  Endo M, Ohba K, Sato S, Yokota Y, Takahashi K.  Increased soluble (pro)renin receptor protein by autophagy inhibition in cultured cancer cells.  Genes Cells  2020    PubMed ID: 32314441   DOI: 10.1111/gtc.12776
12990  Eguchi H, Matsunaga T, Endo S, Ichihara K, Ikari A.  Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression.  Nutrients  2020    PubMed ID: 32340376   DOI: 10.3390/nu12041190
12998  Matsumoto Y, Hattori K, Arima H, Motoyama K, Higashi T, Ishikawa H, Fukumitsu N, Aihara T, Nakai K, Kumada H, Sakurai H.  Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.  Appl Radiat Isot  2020    PubMed ID: 32561042   DOI: 10.1016/j.apradiso.2020.109201
13002  Ihara H, Mitsuishi Y, Kato M, Takahashi F, Tajima K, Hayashi T, Hidayat M, Winardi W, Wirawan A, Hayakawa D, Kanamori K, Matsumoto N, Yae T, Sato T, Sasaki S, Takamochi K, Suehara Y, Ogura D, Niwa SI, Suzuki K, Takahashi K.  Nintedanib inhibits epithelial-mesenchymal transition in A549 alveolar epithelial cells through regulation of the TGF-β/Smad pathway.  Respir Investig  2020    PubMed ID: 32359980   DOI: 10.1016/j.resinv.2020.01.003
13021  Kurita H, Haruta N, Uchihashi Y, Seto T, Takashima K.  Strand breaks and chemical modification of intracellular DNA induced by cold atmospheric pressure plasma irradiation.  PLoS One  2020    PubMed ID: 32374749   DOI: 10.1371/journal.pone.0232724
13089  Ahmed S, Kobayashi H, Afroz T, Ma N, Oikawa S, Kawanishi S, Murata M, Hiraku Y.  Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions.  Sci Rep  2020    PubMed ID: 32612147   DOI: 10.1038/s41598-020-67488-3
13167  Kikuchi N, Soga T, Nomura M, Sato T, Sakamoto Y, Tanaka R, Abe J, Morita M, Shima H, Okada Y, Tanuma N.  Comparison of the ischemic and non-ischemic lung cancer metabolome reveals hyper activity of the TCA cycle and autophagy.  Biochem Biophys Res Commun  2020    PubMed ID: 32828300   DOI: 10.1016/j.bbrc.2020.07.082
13228  Togami K, Maruta Y, Nanbu M, Tada H, Chono S.  Prolonged distribution of aerosolized PEGylated liposomes in the lungs of mice with bleomycin-induced pulmonary fibrosis.  Drug Dev Ind Pharm  2020    PubMed ID: 32940095   DOI: 10.1080/03639045.2020.1825473
13260  Inoue Y, Okamoto T, Honda T, Nukui Y, Akashi T, Takemura T, Tozuka M, Miyazaki Y.  Disruption in the balance between apolipoprotein A-I and mast cell chymase in chronic hypersensitivity pneumonitis.  Immun Inflamm Dis  2020    PubMed ID: 33016012   DOI: 10.1002/iid3.355
13295  Doi T, Ogawa H, Tanaka Y, Hayashi Y, Maniwa Y.  Bex1 significantly contributes to the proliferation and invasiveness of malignant tumor cells.  Oncol Lett  2020    PubMed ID: 33133262   DOI: 10.3892/ol.2020.12226
13342  Chinnathambi S, Hanagata N, Yamazaki T, Shirahata N.  Nano-Bio Interaction between Blood Plasma Proteins and Water-Soluble Silicon Quantum Dots with Enabled Cellular Uptake and Minimal Cytotoxicity.  Nanomaterials (Basel)  2020    PubMed ID: 33202926   DOI: 10.3390/nano10112250
13432  Kenta Shinha, Wataru Nihei, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  A pharmacokinetic–pharmacodynamic model based on multi-organ-on-a-chip for drug–drug interaction studies  Biomicrofluidics  2020      DOI: 10.1063/5.0011545
13523  Hitomi Fujisaki, Sugiko Futaki, Masashi Yamada, Kiyotoshi Sekiguchi, Toshihiko Hayashi, Shunji Hattori  Adhesion to type I collagen fibrous gels induces E- to N-cadherin switching without other EMT-related phenotypes in lung carcinoma cell A549  bioRxiv  2020  October 04    DOI: 10.1101/2020.10.02.323881
13535  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  RNF8 promotes high linear energy transfer carbon-ion-induced DNA double-stranded break repair in serum-starved human cells  DNA Repair (Amst)  2020  91-92:102872  PubMed ID: 32502756   DOI: 10.1016/j.dnarep.2020.102872
13568  Kenta Shinha, Tatsuto Ono, Ryota Nakazato, Hiroshi Kimura  Combination of a multi-organ microphysiological system (MO–MPS) and a pharmacokinetic-pharmacodynamic (PK–PD) model to evaluate drug–drug interactions (DDI)  Authorea Preprints  2020      DOI: 10.22541/au.158316431.10469346
13622  Sato Y, Yoshino H, Tsuruga E, Kashiwakura I.  Fas Ligand Enhances Apoptosis of Human Lung Cancer Cells Cotreated with RIG-I-like Receptor Agonist and Radiation  Curr Cancer Drug Targets  2020  20(5):372-381  PubMed ID: 31951181   DOI: 10.2174/1568009620666200115161717
13767  Togami K, Yamaguchi K, Tada H, Chono S.  Assessment of transporter-mediated efflux of nintedanib using in vitro cell line models of idiopathic pulmonary fibrosis  Pharmazie  2020  75(8):371-374  PubMed ID: 32758335   DOI: 10.1691/ph.2020.0048
13841  Eguchi R, Wakabayashi I.  HDGF enhances VEGF‑dependent angiogenesis and FGF‑2 is a VEGF‑independent angiogenic factor in non‑small cell lung cancer  Oncol Rep  2020  44(1):14-28  PubMed ID: 32319650   DOI: 10.3892/or.2020.7580
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14836  Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M.  Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library  Cell Chem Biol   2020  27(6):708-718.e1  PubMed ID: 32402240   DOI: 10.1016/j.chembiol.2020.04.007
14849  Chikuma K, Arima K, Asaba Y, Kubota R, Asayama S, Sato K, Kawakami H.  The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD  Free Radic Res  2020  54(11-12):829-840  PubMed ID: 31809610   DOI: 10.1080/10715762.2019.1696965
11371  Aki T, Unuma K, Noritake K, Hirayama N, Funakoshi T, Uemura K.  Formation of high molecular weight p62 by CORM-3.  PLoS ONE  2019    PubMed ID: 30620762   DOI: 10.1371/journal.pone.0210474
4061  Kobayashi A, Autsavapromporn N, Ahmad TAFT, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.   BYSTANDER WI-38 CELLS MODULATE DNA DOUBLE-STRAND BREAK REPAIR IN MICROBEAM-TARGETED A549 CELLS THROUGH GAP JUNCTION INTERCELLULAR COMMUNICATION.  Radiat Prot Dosimetry   2019    PubMed ID: 30535060   DOI: 10.1093/rpd/ncy249
4759  Halil I. Ciftci, Mohamed O. Radwan, Safiye E. Ozturk, N. Gokce Ulusoy, Ece Sozer, Doha E. Ellakwa, Zeynep Ocak, Mustafa Can, Taha F.S. Ali, Howaida I. Abd-Alla, Nurettin Yayli, Hiroshi Tateishi, Masami Otsuka and Mikako Fujita  Design, Synthesis and Biological Evaluation of Pentacyclic Triterpene Derivatives: Optimization of Anti-ABL Kinase Activity  Molecules  2019  24:3535  PubMed ID: 31574910   DOI: 10.3390/molecules24193535
5357  Takahashi D, Moriyama J, Nakamura T, Miki E, Takahashi E, Sato A, Akaike T, Itto-Nakama K, Arimoto H.  AUTACs: Cargo-Specific Degraders Using Selective Autophagy.  Mol Cell  2019  76(5):797-810  PubMed ID: 31606272   DOI: 10.1016/j.molcel.2019.09.009
11612  Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.  Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.  Genes Cells  2019    PubMed ID: 31234244   DOI: 10.1111/gtc.12712
11634  Autsavapromporn N, Liu C, Kobayashi A, Ahmad TAFT, Oikawa M, Dukaew N, Wang J, Wongnoppavichb A, Konishic T.  Emerging Role of Secondary Bystander Effects Induced by Fractionated Proton Microbeam Radiation.  Radiat. Res.  2019    PubMed ID: 30526323   DOI: 10.1667/RR15155.1
11675  Dr. Ze Yuan, Prof. Toshihiro Nakamura, Dr. Shanmugavel Chinnathambi, Prof. Yanbai Pu, Prof. Naoto Shirahata, Prof. Kiyoto Matsuishi  Facile Formation of Stable Water‐Dispersed Luminescent Silicon Nanocrystals by Laser Processing in Liquid: Toward Fluorescent Labeling for Bio‐Imaging  CHEMNANOMAT  2019      DOI: 10.1002/cnma.201900289
11808  Sanomachi T, Suzuki S, Togashi K, Seino S, Yoshioka T, Kitanaka C, Okada M, Yamamoto M.  Brexpiprazole Reduces Survivin and Reverses EGFR Tyrosine Kinase Inhibitor Resistance in Lung and Pancreatic Cancer.  Anticancer Res.  2019    PubMed ID: 31519584   DOI: 10.21873/anticanres.13667
11848  Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M.  Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs.  Cancers (Basel)  2019    PubMed ID: 31614999   DOI: 10.3390/cancers11101550
11864  Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K.  Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1.  J. Org. Chem.  2019    PubMed ID: 31642324   DOI: 10.1021/acs.joc.9b02304
9758  Hiromasa Fujita, Katsumi Hirose, Mariko Sato, Ichitaro Fujioka, Tamaki Fujita, Masahiko Aoki, Yoshihiro Takai  Metformin Attenuates Hypoxia-Induced Resistance to Cisplatin in the HepG2 Cell Line  Oncol Lett  2019  17(2):2431-2440  PubMed ID: 30719114   DOI: 10.3892/ol.2018.9869
10357  Belgin Sever, Mehlika Dilek Altıntop, Mohamed O Radwan, Ahmet Özdemir, Masami Otsuka, Mikako Fujita, Halil I Ciftci  Design, synthesis and biological evaluation of a new series of thiazolyl-pyrazolines as dual EGFR and HER2 inhibitors  Eur J Med Chem  2019  82:111648  PubMed ID: 31493743   DOI: 10.1016/j.ejmech.2019.111648
12378  Shirai YT, Mizutani A, Nishijima S, Horie M, Kikuguchi C, Elisseeva O, Yamamoto T.  CNOT3 targets negative cell cycle regulators in non-small cell lung cancer development  Oncogene  2019  38(14):2580-2594  PubMed ID: 30531840   DOI: 10.1038/s41388-018-0603-7
12379  Shiba-Ishii A, Hong J, Hirokawa T, Kim Y, Nakagawa T, Sakashita S, Sakamoto N, Kozuma Y, Sato Y, Noguchi M.  Stratifin Inhibits SCF FBW7 Formation and Blocks Ubiquitination of Oncoproteins during the Course of Lung Adenocarcinogenesis  Clin Cancer Res  2019  25(9):2809-2820  PubMed ID: 30728155   DOI: 10.1158/1078-0432.CCR-18-3631
12380  Chinnathambi S, Hanagata N.  Photostability of quantum dot micelles under ultraviolet irradiation  Luminescence  2019  34(5):472-479  PubMed ID: 30809921   DOI: 10.1002/bio.3618
12381  Lai HW, Sasaki R, Usuki S, Nakajima M, Tanaka T, Ogura SI.  Novel strategy to increase specificity of ALA-Induced PpIX accumulation through inhibition of transporters involved in ALA uptake  Photodiagnosis Photodyn Ther  2019  27:327-335  PubMed ID: 31252141   DOI: 10.1016/j.pdpdt.2019.06.017
12382  Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F.  Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma  Cancer Sci  2019  110(2):726-733  PubMed ID: 30499156   DOI: 10.1111/cas.13895
9502  Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.  PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.  Cancer Cell  2018  33:355-367.e7  PubMed ID: 29533781   DOI: 10.1016/j.ccell.2018.02.004
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323   DOI: 10.1186/s12885-017-3958-1
10803  Sugimoto M, Kitagawa Y, Yamada M, Yajima Y, Utoh R, Seki M.  Micropassage-embedding composite hydrogel fibers enable quantitative evaluation of cancer cell invasion under 3D coculture conditions.  Lab Chip  2018  18:1378-1387  PubMed ID: 29658964   DOI: 10.1039/c7lc01280b
10805  Tahara K, Kobayashi M, Yoshida S, Onodera R, Inoue N, Takeuchi H.  Effects of cationic liposomes with stearylamine against virus infection.  Int J Pharm  2018  543:311-317  PubMed ID: 29625169   DOI: 10.1016/j.ijpharm.2018.04.001
11049  Sasaki M, Anindita PD, Ito N, Sugiyama M, Carr M, Fukuhara H, Ose T, Maenaka K, Takada A, Hall WW, Orba Y, Sawa H  The Role of Heparan Sulfate Proteoglycans as an Attachment Factor for Rabies Virus Entry and Infection.  J Infect Dis  2018  217(11):1740-1749  PubMed ID: 29529215   DOI: 10.1093/infdis/jiy081
11076  Toyama K, Nomura W, Kobayakawa T, Tamamura H.  Delivery of a Proapoptotic Peptide to EGFR-Positive Cancer Cells by a Cyclic Peptide Mimicking the Dimerization Arm Structure of EGFR.  Bioconjug. Chem.  2018  29(6):2050-2057  PubMed ID: 29763296   DOI: 10.1021/acs.bioconjchem.8b00250
11177  Kobayashi A, Konishi T.  Radiation quality effects alteration in COX-2 pathway to trigger radiation-induced bystander response in A549 lung carcinoma cells.  J. Radiat. Res.  2018  59(6):754-759  PubMed ID: 30124879   DOI: 10.1093/jrr/rry065
11164  Mogi K, Hayashida K, Yamamoto T.  Damage-less Handling of Exosomes Using an Ion-depletion Zone in a Microchannel.  Anal Sci  2018  34(8):875-880  PubMed ID: 30101880   DOI: 10.2116/analsci.17P462
4072  Takayuki Hirono et al  MiR-301a/b function as oncomiRs in non-small-cell lung cancer  Integr Mol Med  2018  5: 1-6    DOI: 10.15761/IMM.1000347
4097  Sasaki M, Anindita PD, Phongphaew W, Carr M, Kobayashi S, Orba Y, Sawa H.  Development of a rapid and quantitative method for the analysis of viral entry and release using a NanoLuc luciferase complementation assay.  Virus Res  2018  243:69-74  PubMed ID: 29074234   DOI: 10.1016/j.virusres.2017.10.015
4132  Abd El-Hafeez AA, Fujimura T, Kamei R, Hirakawa N, Baba K, Ono K, Kawamoto S.  Synergistic tumor suppression by a Perilla frutescens-derived methoxyflavanone and anti-cancer tyrosine kinase inhibitors in A549 human lung adenocarcinoma.  Cytotechnology  2018    PubMed ID: 28756527   DOI: 10.1007/s10616-017-0124-1
4133  Kanemaru R, Takahashi F, Kato M, Mitsuishi Y, Tajima K, Ihara H, Hidayat M, Wirawan A, Koinuma Y, Hayakawa D, Yagishita S, Ko R, Sato T, Harada N, Kodama Y, Nurwidya F, Sasaki S, Niwa SI, Takahashi K.  Dasatinib Suppresses TGFβ-Mediated Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells and Inhibits Pulmonary Fibrosis.  Lung  2018    PubMed ID: 29926178   DOI: 10.1007/s00408-018-0134-6
4134  Sato Y, Yoshino H, Kazama Y, Kashiwakura I.  Involvement of caspase‑8 in apoptosis enhancement by cotreatment with retinoic acid‑inducible gene‑I‑like receptor agonist and ionizing radiation in human non‑small cell lung cancer.  Mol Med Rep  2018    PubMed ID: 30320341   DOI: 10.3892/mmr.2018.9536
4135  Horibe S, Kawauchi S, Tanahashi T, Sasaki N, Mizuno S, Rikitake Y.  CD44v-dependent upregulation of xCT is involved in the acquisition of cisplatin-resistance in human lung cancer A549 cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30448176   DOI: 10.1016/j.bbrc.2018.11.055
4136  Sakaizawa T, Matsumura T, Fujii C, Hida S, Toishi M, Shiina T, Yoshida K, Hamanaka K, Ito KI, Taniguchi S.  Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.  Tohoku J. Exp. Med.  2018    PubMed ID: 29459573   DOI: 10.1620/tjem.244.133
4137  Hayashi Y, Higashi T, Motoyama K, Jono H, Ando Y, Arima H.  In vitro and in vivo siRNA delivery to hepatocyte utilizing ternary complexation of lactosylated dendrimer/cyclodextrin conjugates, siRNA and low-molecular-weight sacran.  Int. J. Biol. Macromol.  2018    PubMed ID: 28964842   DOI: 10.1016/j.ijbiomac.2017.09.085
4138  Morimoto Y, Kishida T, Kotani SI, Takayama K, Mazda O.  Interferon-β signal may up-regulate PD-L1 expression through IRF9-dependent and independent pathways in lung cancer cells.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30446226   DOI: 10.1016/j.bbrc.2018.11.035
4139  Sakashita M, Sakashita S, Murata Y, Shiba-Ishii A, Kim Y, Matsuoka R, Nakano N, Sato Y, Noguchi M.  High expression of ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is associated with poor prognosis in lung adenocarcinoma.  Pathol. Int.  2018    PubMed ID: 30320419   DOI: 10.1111/pin.12724
4141  Suzuki S, Okada M, Takeda H, Kuramoto K, Sanomachi T, Togashi K, Seino S, Yamamoto M, Yoshioka T, Kitanaka C.  Involvement of GLUT1-mediated glucose transport and metabolism in gefitinib resistance of non-small-cell lung cancer cells.  Oncotarget  2018    PubMed ID: 30220973   DOI: 10.18632/oncotarget.25994
4468  Sasaki K, Miyashita Y, Asai D, Funamoto D, Sato K, Yamaguchi Y, Mishima Y, Iino T, Takaishi S, Nagano J, Kishimura A, Mori T, Katayama Y.  A peptide inhibitor of antibody-dependent cell-mediated cytotoxicity against EGFR/folate receptor-α double positive cells.  Medchemcomm  2018  9(5):783-788  PubMed ID: 30108967   DOI: 10.1039/c8md00010g
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516   DOI: 10.18632/oncotarget.13761
10274  Akihisa T, Yokokawa S, Ogihara E, Matsumoto M, Zhang J, Kikuchi T, Koike K, Abe M.  Melanogenesis-Inhibitory and Cytotoxic Activities of Limonoids, Alkaloids, and Phenolic Compounds from Phellodendron amurense Bark.  Chem. Biodivers.  2017  14:  PubMed ID: 28425165   DOI: 10.1002/cbdv.201700105
10280  Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A.  AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier.  Oncol. Rep.  2017  37:3261-3269  PubMed ID: 28440492   DOI: 10.3892/or.2017.5594
10381  Kobayashi A, Tengku Ahmad TAF, Autsavapromporn N, Oikawa M, Homma-Takeda S, Furusawa Y, Wang J, Konishi T.  Enhanced DNA double-strand break repair of microbeam targeted A549 lung carcinoma cells by adjacent WI38 normal lung fibroblast cells via bi-directional signaling.  Mutat. Res.  2017  803-805:1-8  PubMed ID: 28689138   DOI: 10.1016/j.mrfmmm.2017.06.006
10924    Biocompatible CdSe/ZnS quantum dot micelles for long-term cell imaging without alteration to the native structure of the blood plasma protein human serum albumin  RSC Adv  2017  7, 2392-2402    DOI: 10.1039/C6RA26592H
4526  Yusuke Hiraku, Yoshihiro Nishikawa, Ning Ma, Tahmina Afroza, Kosuke Mizobuchi, Ryo Ishiyama, Yuta Matsunaga, Takamichi Ichinose, Shosuke Kawanishi, Mariko Murata  Nitrative DNA damage induced by carbon-black nanoparticles in macrophages and lung epithelial cells  Mutation Research/Genetic Toxicology and Environmental Mutagenesis  2017  818, 7-16  PubMed ID: 28477879   DOI: 10.1016/j.mrgentox.2017.04.002
9171  Haruhiko Fuwa, Mizuho Sato  A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells  Mar Drugs  2017  15 (10)  PubMed ID: 29053565   DOI: 10.3390/md15100320
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625   DOI: 10.3892/ijo.2017.3859
12213  Cancer Lett  Lipophilic triphenylphosphonium derivatives enhance radiation-induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells    2017  390:160-167  PubMed ID: 28093283   DOI: 10.1016/j.canlet.2017.01.006
12218  Kohei Togami, Kotaro Yamaguchi, Sumio Chono, Hitoshi Tada  Evaluation of permeability alteration and epithelial-mesenchymal transition induced by transforming growth factor-β 1 in A549, NCI-H441, and Calu-3 cells: Development of an in vitro model of respiratory epithelial cells in idiopathic pulmonary fibrosis  J Pharmacol Toxicol Methods  2017  86:19-27.  PubMed ID: 28259823   DOI: 10.1016/j.vascn.2017.02.023
14030  El-Aarag B, Kasai T, Masuda J, Agwa H, Zahran M, Seno M.  Anticancer effects of novel thalidomide analogs in A549 cells through inhibition of vascular endothelial growth factor and matrix metalloproteinase-2  Biomed Pharmacother  2017  85:549-555  PubMed ID: 27889230   DOI: 10.1016/j.biopha.2016.11.063
14081  Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H.  IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models  Allergy  2017  72(7):1043-1053.   PubMed ID: 27878831   DOI: 10.1111/all.13079
14432  Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M.  miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma  Cancer Sci  2017  108(3):536-542  PubMed ID: 28012229   DOI: 10.1111/cas.13148
14529  Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R.  Oxygen Enhancement Ratio in Radiation-Induced Initial DSBs by an Optimized Flow Cytometry-based Gamma-H2AX Analysis in A549 Human Cancer Cells  Radiat Res  2017  188(5):591-594  PubMed ID: 28829673   DOI: 10.1667/RR14824.1
14665  Takahashi K, Ohta T.  Membrane translocation of transient receptor potential ankyrin 1 induced by inflammatory cytokines in lung cancer cells  Biochem Biophys Res Commun  2017  490(3):587-593  PubMed ID: 28629997   DOI: 10.1016/j.bbrc.2017.06.082
14674  Piao W, Hanaoka K, Fujisawa T, Takeuchi S, Komatsu T, Ueno T, Terai T, Tahara T, Nagano T, Urano Y.  Development of an Azo-Based Photosensitizer Activated under Mild Hypoxia for Photodynamic Therapy  J Am Chem Soc  2017  139(39):13713-13719  PubMed ID: 28872304   DOI: 10.1021/jacs.7b05019
14730  Ogawa H, Koyanagi-Aoi M, Otani K, Zen Y, Maniwa Y, Aoi T.  Interleukin-6 blockade attenuates lung cancer tissue construction integrated by cancer stem cells  Sci Rep  2017  7(1):12317.  PubMed ID: 28951614   DOI: 10.1038/s41598-017-12017-y
16608  Sanomachi T, Suzuki S, Kuramoto K, Takeda H, Sakaki H, Togashi K, Seino S, Yoshioka T, Okada M, Kitanaka C.  Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents  Anticancer Res  2017  37(11):6177-6188  PubMed ID: 29061799   DOI: 10.21873/anticanres.12067
7063  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I.  Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.  Nat. Biotechnol.  2016  34:1060-1065  PubMed ID: 27571369   DOI: 10.1038/nbt.3658
7193  Yamazoe H, Hagihara Y, Kobayashi H.  Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs.  Tissue Eng Part C Methods  2016  22:20-9  PubMed ID: 26421875   DOI: 10.1089/ten.TEC.2015.0188
9581  Shimobaba S, Taga S, Akizuki R, Hichino A, Endo S, Matsunaga T, Watanabe R, Yamaguchi M, Yamazaki Y, Sugatani J, Ikari A.  Claudin-18 inhibits cell proliferation and motility mediated by inhibition of phosphorylation of PDK1 and Akt in human lung adenocarcinoma A549 cells.  Biochim. Biophys. Acta  2016  1863:1170-8  PubMed ID: 26919807   DOI: 10.1016/j.bbamcr.2016.02.015
9774  Nagashima S, Kobayashi T, Tanaka T, Tanggis , Jirintai S, Takahashi M, Nishizawa T, Okamoto H.  Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.  Virus Res.  2016  223:170-80  PubMed ID: 27485920   DOI: 10.1016/j.virusres.2016.07.011
9884  Watarai H, Okada M, Kuramoto K, Takeda H, Sakaki H, Suzuki S, Seino S, Oizumi H, Sadahiro M, Kitanaka C.  Impact of H3K27 Demethylase Inhibitor GSKJ4 on NSCLC Cells Alone and in Combination with Metformin.  Anticancer Res.  2016  36:6083-6092  PubMed ID: 27793936   DOI: 10.21873/anticanres.11198
9117  Soshi Seike, Kazuaki Miyamoto, Keiko Kobayashi, Masaya Takehara, Masahiro Nagahama  Clostridium Perfringens Delta-Toxin Induces Rapid Cell Necrosis  PLoS One  2016  11 (1), e0147957  PubMed ID: 26807591   DOI: 10.1371/journal.pone.0147957
10117  Takahiro Nomoto, Shigeto Fukushima, Michiaki Kumagai, Kozo Miyazaki, Aki Inoue, Peng Mi, Yoshinori Maeda, Kazuko Toh, Yu Matsumoto, Yuji Morimoto, Akihiro Kishimura, Nobuhiro Nishiyama, Kazunori Kataoka  Calcium Phosphate-Based Organic-Inorganic Hybrid Nanocarriers With pH-responsive on/Off Switch for Photodynamic Therapy  Biomater Sci .   2016  4(5):826-38  PubMed ID: 26971562   DOI: 10.1039/c6bm00011h
12614  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  Intracellular accumulation of indium ions released from nanoparticles induces oxidative stress, proinflammatory response and DNA damage  J Biochem  2016  159(2):225-37  PubMed ID: 26378248   DOI: 10.1093/jb/mvv098
12629  Takeda H, Okada M, Suzuki S, Kuramoto K, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Rho-Associated Protein Kinase (ROCK) Inhibitors Inhibit Survivin Expression and Sensitize Pancreatic Cancer Stem Cells to Gemcitabine  Anticancer Res  2016  36(12):6311-6318  PubMed ID: 27919951   DOI: 10.21873/anticanres.11227
12630  Okada M, Kuramoto K, Takeda H, Watarai H, Sakaki H, Seino S, Seino M, Suzuki S, Kitanaka C.  The novel JNK inhibitor AS602801 inhibits cancer stem cells in vitro and in vivo  Oncotarget  2016  7(19):27021-32  PubMed ID: 27027242   DOI: 10.18632/oncotarget.8395
12631  Hino H, Kamiya M, Kitano K, Mizuno K, Tanaka S, Nishiyama N, Kataoka K, Urano Y, Nakajima J.  Rapid Cancer Fluorescence Imaging Using A γ-Glutamyltranspeptidase-Specific Probe For Primary Lung Cancer  Transl Oncol  2016  9(3):203-10  PubMed ID: 27267838   DOI: 10.1016/j.tranon.2016.03.007
12646  Husni RE, Shiba-Ishii A, Iiyama S, Shiozawa T, Kim Y, Nakagawa T, Sato T, Kano J, Minami Y, Noguchi M.  DNMT3a expression pattern and its prognostic value in lung adenocarcinoma  Lung Cancer  2016  97:59-65  PubMed ID: 27237029   DOI: 10.1016/j.lungcan.2016.04.018
12681  Toyama K, Mizuguchi T, Nomura W, Tamamura H.  Functional evaluation of fluorescein-labeled derivatives of a peptide inhibitor of the EGF receptor dimerization  Bioorg Med Chem  2016  24(16):3406-12  PubMed ID: 27283787   DOI: 10.1016/j.bmc.2016.05.026
12948  Ali F, Yamaguchi K, Fukuoka M, Elhelaly AE, Kuwata K.  Logical design of an anti-cancer agent targeting the plant homeodomain in Pygopus2  Cancer Sci  2016  107(9):1321-8  PubMed ID: 27324116   DOI: 10.1111/cas.12995
12949  Fukushi S, Yoshino H, Yoshizawa A, Kashiwakura I.  p53-independent structure-activity relationships of 3-ring mesogenic compounds' activity as cytotoxic effects against human non-small cell lung cancer lines  BMC Cancer  2016  16:521  PubMed ID: 27456853   DOI: 10.1186/s12885-016-2585-6
12974  Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, Murata M.  Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation  Part Fibre Toxicol  2016  13:16  PubMed ID: 27026438   DOI: 10.1186/s12989-016-0127-7
13469  Tanabe K.  Image-based compound profiling reveals a dual inhibitor of tyrosine kinase and microtubule polymerization  Sci Rep  2016  6:25095  PubMed ID: 27117592   DOI: 10.1038/srep25095
13976  Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, Fujimori A, Uesaka M, Okayasu R.  Nontoxic concentration of DNA-PK inhibitor NU7441 radio-sensitizes lung tumor cells with little effect on double strand break repair  Cancer Sci  2016  107(9):1250-5  PubMed ID: 27341700   DOI: 10.1111/cas.12998
13996  Rana U, Chakraborty C, Pandey RK, Hossain MD, Nagano R, Morita H, Hattori S, Minowa T, Higuchi M.  Selective DNA Recognition and Cytotoxicity of Water-Soluble Helical Metallosupramolecular Polymers  Bioconjug Chem  2016  27(10):2307-2314  PubMed ID: 27580353   DOI: 10.1021/acs.bioconjchem.6b00255
14026  Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.  Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance  Anticancer Res  2016  36(10):5153-5161  PubMed ID: 27798875   DOI: 10.21873/anticanres.11085
14028  Maeda K, Yasui H, Yamamori T, Matsuura T, Takao S, Suzuki M, Matsuda A, Inanami O, Shirato H.  A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam  PLoS One  2016  11(11):e0166848  PubMed ID: 27875573   DOI: 10.1371/journal.pone.0166848
14041  Zhang J, Yamada S, Ogihara E, Kurita M, Banno N, Qu W, Feng F, Akihisa T.  Biological Activities of Triterpenoids and Phenolic Compounds from Myrica cerifera Bark  Chem Biodivers  2016  13(11):1601-1609  PubMed ID: 27492128   DOI: 10.1002/cbdv.201600247
14095  Nozomu Kiyama, Shigeaki Abe, Shuichi Yamagata, Yasuhiro Yoshida, Junichiro Iida  Evaluation of the Biocompatibility of Ceramic Nanoparticles with A549 Lung Epithelial Cells  Nanoscience and Nanotechnology Letters  2016  8:310-315    DOI: 10.1166/nnl.2016.2132
17169  Kurimoto S, Pu JX, Sun HD, Shibata H, Takaishi Y, Kashiwada Y.  Acylated neo-clerodane type diterpenoids from the aerial parts of Scutellaria coleifolia Levl. (Lamiaceae)  J Nat Med  2016  70(2):241-52  PubMed ID: 26825781   DOI: 10.1007/s11418-016-0967-3
5653  Tabata A, Ohkubo Y, Anyoji N, Hojo K, Tomoyasu T, Tatematsu Y, Ohkura K, Nagamune H.  Development of a Sortase A-mediated Peptide-labeled Liposome Applicable to Drug-delivery Systems.  Anticancer Res  2015  35(8):4411-7  PubMed ID: 26168480  
14286  Katono K, Sato Y, Jiang SX, Kobayashi M, Nagashio R, Ryuge S, Fukuda E, Goshima N, Satoh Y, Saegusa M, Masuda N.  Prognostic significance of MYH9 expression in resected non-small cell lung cancer  PLoS One  2015  10(3):e0121460  PubMed ID: 25826333   DOI: 10.1371/journal.pone.0121460
14460  Hosokawa Y, Monzen S, Yoshino H, Terashima S, Nakano M, Toshima K, Saga R, Kashiwakura I.  Effects of X‑ray irradiation in combination with ascorbic acid on tumor control  Mol Med Rep  2015  12(4):5449-54  PubMed ID: 26238154   DOI: 10.3892/mmr.2015.4108
14953  Yoshimasu T, Ohashi T, Oura S, Kokawa Y, Kawago M, Hirai Y, Miyasaka M, Nishiguchi H, Kawashima S, Yata Y, Honda M, Fujimoto T, Okamura Y.  A Theoretical Model for the Hormetic Dose-response Curve for Anticancer Agents  Anticancer Res  2015  35(11):5851-5  PubMed ID: 26504007  
15015  Okada K, Chikumi H, Takata M, Yamaguchi K, Makino H, Kitaura T, Nakamoto M, Yamasaki A, Igishi T, Burioka N, Shimizu E.  Effect of Clarithromycin on the Expression of UL16-Binding Protein 2 in Human Cells  Yonago Acta Med  2015  58(1):31-8  PubMed ID: 26190895  
15069  Zhang J, Kurita M, Ebina K, Ukiya M, Tokuda H, Yasukawa K, Masters ET, Shimizu N, Akihisa M, Feng F, Akihisa T.  Melanogenesis-inhibitory activity and cancer chemopreventive effect of glucosylcucurbic acid from shea (Vitellaria paradoxa) kernels  Chem Biodivers  2015  12(4):547-58  PubMed ID: 25879500   DOI: 10.1002/cbdv.201400424
15117  Sugano T, Seike M, Noro R, Soeno C, Chiba M, Zou F, Nakamichi S, Nishijima N, Matsumoto M, Miyanaga A, Kubota K, Gemma A.  Inhibition of ABCB1 Overcomes Cancer Stem Cell-like Properties and Acquired Resistance to MET Inhibitors in Non-Small Cell Lung Cancer  Mol Cancer Ther  2015  14(11):2433-40  PubMed ID: 26351321   DOI: 10.1158/1535-7163.MCT-15-0050
15198  Pauli G, Aepfelbacher M, Bauerfeind U, Blümel J, Burger R, Gärtner B, Gröner A, Gürtler L, Heiden M, Hildebrandt M, Jansen B, Offergeld R, Schlenkrich U, Schottstedt V, Seitz R, Strobel J, Willkommen H, Baylis SA, German Advisory Committee Blood (Arbeitskreis Blut), Subgroup ‘Assessment of Pathogens Transmissible by Blood’.  Hepatitis E Virus  Transfus Med Hemother  2015  2(4):247-65.  PubMed ID: 26557817   DOI: 10.1159/000431191
15455  Tabei Y, Sonoda A, Nakajima Y, Biju V, Makita Y, Yoshida Y, Horie M.  In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells  Metallomics  2015  7(5):816-27  PubMed ID: 25781390   DOI: 10.1039/c5mt00031a
5612  Yamada A, Aki T, Unuma K, Funakoshi T, Uemura K.  Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells  PLoS One  2015  10(3):e0120192  PubMed ID: 25799450   DOI: 10.1371/journal.pone.0120192
17443  Kimura H, Ikeda T, Nakayama H, Sakai Y, Fujii T.  An on-chip small intestine-liver model for pharmacokinetic studies  J Lab Autom  2015  20(3):265-73  PubMed ID: 25385717   DOI: 10.1177/2211068214557812
18179  Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.  Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses  Elife  2014  3:e04177  PubMed ID: 25149452   DOI: 10.7554/eLife.04177
6014  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H.  Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies.  J Gen Virol  2014  95(Pt 10):2166-75  PubMed ID: 24970738   DOI: 10.1099/vir.0.066910-0
10200  Masanori Horie, Keiko Nishio, Haruhisa Kato, Shigehisa Endoh, Katsuhide Fujita, Ayako Nakamura, Shinichi Kinugasa, Yoshihisa Hagihara, Yasukazu Yoshida, Hitoshi Iwahashi   Evaluation of Cellular Influences Caused by Calcium Carbonate Nanoparticles  Chem Biol Interact .  2014  210:64-76  PubMed ID: 24412303   DOI: 10.1016/j.cbi.2013.12.013
13754  Narita K, Matsuda Y, Seike M, Naito Z, Gemma A, Ishiwata T.  Nestin regulates proliferation, migration, invasion and stemness of lung adenocarcinoma  Int J Oncol   2014  44(4):1118-30  PubMed ID: 24481417   DOI: 10.3892/ijo.2014.2278
15845  Kitamura K, Seike M, Okano T, Matsuda K, Miyanaga A, Mizutani H, Noro R, Minegishi Y, Kubota K, Gemma A.  MiR-134/487b/655 cluster regulates TGF-β-induced epithelial-mesenchymal transition and drug resistance to gefitinib by targeting MAGI2 in lung adenocarcinoma cells  Mol Cancer Ther  2014  13(2):444-53  PubMed ID: 24258346   DOI: 10.1158/1535-7163.MCT-13-0448
16547  Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, Suzuki T, Koike K, Akihisa R, Akihisa T.  Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities  Chem Biodivers  2014  11(7):987-1000  PubMed ID: 25044585   DOI: 10.1002/cbdv.201400052
16548  Kitdamrongtham W, Ishii K, Ebina K, Zhang J, Ukiya M, Koike K, Akazawa H, Manosroi A, Manosroi J, Akihisa T.  Limonoids and flavonoids from the flowers of Azadirachta indica var. siamensis, and their melanogenesis-inhibitory and cytotoxic activities  Chem Biodivers  2014  11(1):73-84  PubMed ID: 24443427   DOI: 10.1002/cbdv.201300266
17116  Yukako Fukushi, Hironori Yoshino, Junya Ishikawa, Masanobu Sagisaka, Ikuo Kashiwakura, Atsushi Yoshizawa  Effects of liquid crystallinity on anticancer activity of benzoate derivatives possessing a terminal hydroxyl group  Liquid Crystals  2014  41:1873-1878    DOI: 10.1080/02678292.2014.956350
17137  Mamdouh N. Samy, Sachiko Sugimoto, Katsuyoshi Matsunami, Hideaki Otsuka, Mohamed S. Kamel  One new flavonoid xyloside and one new natural triterpene rhamnoside from the leaves of Syzygium grande  Phytochemistry Letters  2014  10:86-90    DOI: 10.1016/j.phytol.2014.08.009
17167  Fukushi Y , Yoshino H , Ishikawa J , Sagisaka M , Kashiwakura I , Yoshizawa A .  Synthesis and anticancer properties of phenyl benzoate derivatives possessing a terminal hydroxyl group  J Mater Chem B  2014  2(10):1335-1343  PubMed ID: 32261448   DOI: 10.1039/c3tb21736a
18241  Kawai K, Ieda N, Aizawa K, Suzuki T, Miyata N, Nakagawa H.  A reductant-resistant and metal-free fluorescent probe for nitroxyl applicable to living cells   J Am Chem Soc  2013  135(34):12690-6  PubMed ID: 23865676   DOI: 10.1021/ja404757s
18463  Horie M, Nishio K, Kato H, Shinohara N, Nakamura A, Fujita K, Kinugasa S, Endoh S, Yoshida Y, Hagihara Y, Iwahashi H.  In vitro evaluation of cellular influences induced by stable fullerene C₇₀ medium dispersion: induction of cellular oxidative stress  Chemosphere  2013  93(6):1182-8  PubMed ID: 23886439   DOI: 10.1016/j.chemosphere.2013.06.067
3914  Kazuhiro Hiyama, Hirofumi Matsui, Masato Tamura, Osamu Shimokawa, Mariko Hiyama, Tsuyoshi Kaneko, Yumiko Nagano, Ichinosuke Hyodo, Junko Tanaka, Yoshihiro Miwa, Tetsuo Ogawa, Takeo Nakanishi and Ikumi Tamai  Cancer cells uptake porphyrins via heme carrier protein 1  Journal of Porphyrins and Phthalocyanines  2013  17:36-43    DOI: 10.1142/S1088424612501192
15793  Masayasu Mie, Mayu Oomuro, Eiry Kobatake  Hydrogel scaffolds composed of genetically synthesized self-assembling peptides for three-dimensional cell culture  Polymer Journal  2013  45:504-508    DOI: 10.1038/pj.2012.216
15922  Fujitani N, Furukawa J, Araki K, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y.  Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers  Proc Natl Acad Sci U S A   2013  110(6):2105-10  PubMed ID: 23345451   DOI: 10.1073/pnas.1214233110
16601  Ukiya M, Sawada S, Kikuchi T, Kushi Y, Fukatsu M, Akihisa T.  Cytotoxic and apoptosis-inducing activities of steviol and isosteviol derivatives against human cancer cell lines  Chem Biodivers  2013  10(2):177-88  PubMed ID: 23418165   DOI: 10.1002/cbdv.201200406
18586  Matsuo K, Nakagawa H, Adachi Y, Kameda E, Aizawa K, Tsumoto H, Suzuki T, Miyata N.  Photoinduced upregulation of calcitonin gene-related peptide in A549 cells through HNO release from a hydrophilic photocontrollable HNO donor  Chem Pharm Bull (Tokyo)  2012  60(8):1055-62  PubMed ID: 22863710   DOI: 10.1248/cpb.c12-00348
18765  Sumitomo T, Nakata M, Yamaguchi M, Terao Y, Kawabata S.  S-carboxymethylcysteine inhibits adherence of Streptococcus pneumoniae to human alveolar epithelial cells  J Med Microbiol  2012  61(Pt 1):101-108  PubMed ID: 21890513   DOI: 10.1099/jmm.0.033688-0
5376  Murata M, Nakano K, Tahara K, Tozuka Y, Takeuchi H.  Pulmonary delivery of elcatonin using surface-modified liposomes to improve systemic absorption: polyvinyl alcohol with a hydrophobic anchor and chitosan oligosaccharide as effective surface modifiers.  Eur J Pharm Biopharm  2012  80(2):340-6  PubMed ID: 22036988   DOI: 10.1016/j.ejpb.2011.10.011
5620  Tabata A, Ohkubo Y, Sakakura E, Tomoyasu T, Ohkura K, Nagamune H.  Investigation of a bacterial pore-forming chimera toxin for application as a novel drug-delivery system tool.  Anticancer Res  2012  32(6):2323-9  PubMed ID: 22641669  
6432  Jirintai S, Jinshan, Tanggis, Manglai D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H.  Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells.  Virus Res  2012  170(1-2):126-37  PubMed ID: 23041252   DOI: 10.1016/j.virusres.2012.09.015
12718  Ikari A, Sato T, Watanabe R, Yamazaki Y, Sugatani J.  Increase in claudin-2 expression by an EGFR/MEK/ERK/c-Fos pathway in lung adenocarcinoma A549 cells  Biochim Biophys Acta  2012  1823(6):1110-8  PubMed ID: 22546605   DOI: 10.1016/j.bbamcr.2012.04.005
16032  Takahashi H, Tanaka T, Jirintai S, Nagashima S, Takahashi M, Nishizawa T, Mizuo H, Yazaki Y, Okamoto H.  A549 and PLC/PRF/5 cells can support the efficient propagation of swine and wild boar hepatitis E virus (HEV) strains: demonstration of HEV infectivity of porcine liver sold as food  Arch Virol  2012  157(2):235-46.  PubMed ID: 22048607   DOI: 10.1007/s00705-011-1153-2
16490  Shiba-Ishii A, Noguchi M.  Aberrant stratifin overexpression is regulated by tumor-associated CpG demethylation in lung adenocarcinoma  Am J Pathol  2012  180(4):1653-62  PubMed ID: 22310466   DOI: 10.1016/j.ajpath.2011.12.014
16596  Minakata K, Takahashi F, Nara T, Hashimoto M, Tajima K, Murakami A, Nurwidya F, Yae S, Koizumi F, Moriyama H, Seyama K, Nishio K, Takahashi K.  Hypoxia induces gefitinib resistance in non-small-cell lung cancer with both mutant and wild-type epidermal growth factor receptors  Cancer Sci  2012  103(11):1946-54  PubMed ID: 22863020   DOI: 10.1111/j.1349-7006.2012.02408.x
16599  Yamadori T, Ishii Y, Homma S, Morishima Y, Kurishima K, Itoh K, Yamamoto M, Minami Y, Noguchi M, Hizawa N.  Molecular mechanisms for the regulation of Nrf2-mediated cell proliferation in non-small-cell lung cancers  Oncogene  2012  31(45):4768-77  PubMed ID: 22249257   DOI: 10.1038/onc.2011.628
17472  Ashinuma H, Takiguchi Y, Kitazono S, Kitazono-Saitoh M, Kitamura A, Chiba T, Tada Y, Kurosu K, Sakaida E, Sekine I, Tanabe N, Iwama A, Yokosuka O, Tatsumi K.  Antiproliferative action of metformin in human lung cancer cell lines  Oncol Rep  2012  28(1):8-14  PubMed ID: 22576795   DOI: 10.3892/or.2012.1763
7717  Miura T, Kakehashi H, Shinkai Y, Egara Y, Hirose R, Cho AK, Kumagai Y.  GSH-mediated S-transarylation of a quinone glyceraldehyde-3-phosphate dehydrogenase conjugate.  Chem. Res. Toxicol.  2011  24:1836-44  PubMed ID: 21827172   DOI: 10.1021/tx200025y
7765  Herlambang S, Kumagai M, Nomoto T, Horie S, Fukushima S, Oba M, Miyazaki K, Morimoto Y, Nishiyama N, Kataoka K.  Disulfide crosslinked polyion complex micelles encapsulating dendrimer phthalocyanine directed to improved efficiency of photodynamic therapy.  J Control Release  2011  155:449-57  PubMed ID: 21704092   DOI: 10.1016/j.jconrel.2011.06.019
7806  Hoshino A, Ishii G, Ito T, Aoyagi K, Ohtaki Y, Nagai K, Sasaki H, Ochiai A.  Podoplanin-positive fibroblasts enhance lung adenocarcinoma tumor formation: podoplanin in fibroblast functions for tumor progression.  Cancer Res.  2011  71:4769-79  PubMed ID: 21610106   DOI: 10.1158/0008-5472.CAN-10-3228
7900  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improvements in transfection efficiency with chitosan modified poly(DL-lactide-co-glycolide) nanospheres prepared by the emulsion solvent diffusion method, for gene delivery.  Chem. Pharm. Bull.  2011  59:298-301  PubMed ID: 21372409   DOI: 10.1248/cpb.59.298
7951  Okamoto H.  Hepatitis E virus cell culture models.  Virus Res.  2011  161:65-77  PubMed ID: 21316402   DOI: 10.1016/j.virusres.2011.01.015
18332  Motoyama K, Nakashima Y, Aramaki Y, Hirayama F, Uekama K, Arima H.  In Vitro Gene Delivery Mediated by Asialofetuin-Appended Cationic Liposomes Associated with γ-Cyclodextrin into Hepatocytes  J Drug Deliv  2011  2011:476137  PubMed ID: 21490752   DOI: 10.1155/2011/476137
8125  Ishigaki Y, Nakamura Y, Takehara T, Nemoto N, Kurihara T, Koga H, Nakagawa H, Takegami T, Tomosugi N, Miyazawa S, Kuwabata S.  Ionic liquid enables simple and rapid sample preparation of human culturing cells for scanning electron microscope analysis.  Microsc. Res. Tech.  2011  74:415-20  PubMed ID: 20830703   DOI: 10.1002/jemt.20924
8176  Haruki T, Shomori K, Hamamoto Y, Taniguchi Y, Nakamura H, Ito H.  Geminin expression in small lung adenocarcinomas: implication of prognostic significance.  Lung Cancer  2011  71:356-62  PubMed ID: 20650542   DOI: 10.1016/j.lungcan.2010.06.013
18789  Kikuchi T, Ishii K, Noto T, Takahashi A, Tabata K, Suzuki T, Akihisa T.  Cytotoxic and apoptosis-inducing activities of limonoi  J Nat Prod  2011  74(4):866-70  PubMed ID: 21381696   DOI: 10.1021/np100783k
5322  Akihisa T, Kikuchi T, Nagai H, Ishii K, Tabata K, Suzuki T.  4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells.  J Oleo Sci  2011  60(2):71-7  PubMed ID: 21263202   DOI: 10.5650/jos.60.71
5863  Yoshii Y, Waki A, Yoshida K, Kakezuka A, Kobayashi M, Namiki H, Kuroda Y, Kiyono Y, Yoshii H, Furukawa T, Asai T, Okazawa H, Gelovani JG, Fujibayashi Y.  The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation.  Biomaterials  2011  32(26):6052-8  PubMed ID: 21640378   DOI: 10.1016/j.biomaterials.2011.04.076
6008  Horie M, Kato H, Endoh S, Fujita K, Nishio K, Komaba LK, Fukui H, Nakamura A, Miyauchi A, Nakazato T, Kinugasa S, Yoshida Y, Hagihara Y, Morimoto Y, Iwahashi H.  Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.  Metallomics  2011  3(11):1244-52  PubMed ID: 21804981   DOI: 10.1039/c1mt00060h
9083  Masahiro Nagahama, Mariko Umezaki, Masataka Oda, Keiko Kobayashi, Shigenobu Tone, Taiji Suda, Kazumi Ishidoh, Jun Sakurai  Clostridium Perfringens Iota-Toxin B Induces Rapid Cell Necrosis  Infect Immun  2011  79 (11), 4353-60  PubMed ID: 21911469   DOI: 10.1128/IAI.05677-11
12748  Ikari A, Sato T, Takiguchi A, Atomi K, Yamazaki Y, Sugatani J.  Claudin-2 knockdown decreases matrix metalloproteinase-9 activity and cell migration via suppression of nuclear Sp1 in A549 cells  Life Sci  2011  88(13-14):628-33  PubMed ID: 21315735   DOI: 10.1016/j.lfs.2011.02.002
16488  Shiba-Ishii A, Kano J, Morishita Y, Sato Y, Minami Y, Noguchi M.  High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinoma  Int J Cancer  2011  129(10):2445-53  PubMed ID: 21207417   DOI: 10.1002/ijc.25907
16552  Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N.  ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer  Br J Cancer  2011  104(4):700-6  PubMed ID: 21285982   DOI: 10.1038/sj.bjc.6606012
16553  Hayashi S, Kumai T, Matsuda Y, Aoki N, Sato K, Kimura S, Kitada M, Tateno M, Celis E, Kobayashi H.  Six-transmembrane epithelial antigen of the prostate and enhancer of zeste homolog 2 as immunotherapeutic targets for lung cancer  J Transl Med  2011  9:191  PubMed ID: 22053850   DOI: 10.1186/1479-5876-9-191
18333  Horie M, Nishio K, Kato H, Shinohara N, Nakamura A, Fujita K, Kinugasa S, Endoh S, Yamamoto K, Yamamoto O, Niki E, Yoshida Y, Iwahashi H.  In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion  J Biochem  2010  148(3):289-98  PubMed ID: 20576621   DOI: 10.1093/jb/mvq068
8043  Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T.  Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway.  J. Pharmacol. Sci.  2010  114:420-32  PubMed ID: 21127389   DOI: 10.1254/jphs.10181fp
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387   DOI: 10.1038/sj.bjc.6605786
8238  Horie M, Nishio K, Fujita K, Kato H, Endoh S, Suzuki M, Nakamura A, Miyauchi A, Kinugasa S, Yamamoto K, Iwahashi H, Murayama H, Niki E, Yoshida Y.  Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less.  Toxicol In Vitro  2010  24:1629-38  PubMed ID: 20541599   DOI: 10.1016/j.tiv.2010.06.003
8346  Ishikawa Y, Nagai J, Okada Y, Sato K, Yumoto R, Takano M.  Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.  Biol. Pharm. Bull.  2010  33:504-11  PubMed ID: 20190417   DOI: 10.1248/bpb.33.504
5870  Takahashi N, Fukushima T, Yorita K, Tanaka H, Chijiiwa K, Kataoka H.  Dickkopf-1 is overexpressed in human pancreatic ductal adenocarcinoma cells and is involved in invasive growth.  Int J Cancer.  2010  126(7):1611-20  PubMed ID: 19711349   DOI: 10.1002/ijc.24865
12266  Kohei Tahara, Hiromitsu Yamamoto, Naohide Hirashima, Yoshiaki Kawashima  Chitosan-modified poly(D,L-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects  Eur J Pharm Biopharm  2010  74(3):421-6  PubMed ID: 20034563   DOI: 10.1016/j.ejpb.2009.12.007
6124  Nguyen Bich Thu et al  Screening of Vietnamese medicinal plants for cytotoxic activity  Natural Product Sciences  2010  16(1)   
11378  T. Ohnuma, T. Matsumoto, T. Komats, T. Nishiyama, K. Ogura, H. Iwata, A. Hiratsuka  Role of phase 2 drug-metabolizing enzymes modulated by extracts from 78 herbal medicines in detoxification of electrophiles and lung cancer chemotherapy.  J Traditional Medicines  2010  27:122-133    DOI: 10.11339/jtm.27.122
13818  Kikuji Yamashita, Shine-Od Dalkhsuren, Tatsuo Ishikawa, Kaori Sumida, Jun Ishibashi, Hiroyoshi Hosokawa, Akemichi Ueno, Fumio Nasu, Seiichiro Kitamura  Far Infrared Ray Radiation Inhibits the Proliferation of A549, HSC3 and Sa3 Cancer Cells through Enhancing the Expression of ATF3 Gene  Journal of Electromagnetic Analysis and Applications  2010  2:382-394    DOI: 10.4236/jemaa.2010.26050
16149  Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Omura K, Nguyen ST, Miki Y, Iimura T, Himeno A, Akashi T, Yamada-Okabe H, Ogata E, Yamaguchi A.  Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells  Am J Pathol  2010  176(2):968-80  PubMed ID: 20035059   DOI: 10.2353/ajpath.2010.090299
16518  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines  Nat Prod Commun  2010  5(10):1601-6.  PubMed ID: 21121257  
16551  Song X, Chen Z, Wu C, Zhao S.  Abrogating HSP response augments cell death induced by As2O3 in glioma cell lines  Can J Neurol Sci  2010  37(4):504-11  PubMed ID: 20724260   DOI: 10.1017/s0317167100010544
18295  Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M.  Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer  Clin Cancer Res  2009  15(10):3423-32  PubMed ID: 19417020   DOI: 10.1158/1078-0432.CCR-08-2822
18297  Hazawa M, Wada K, Takahashi K, Mori T, Kawahara N, Kashiwakura I.  Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth  Invest New Drugs  2009  27(2):111-9  PubMed ID: 18551247   DOI: 10.1007/s10637-008-9141-4
18300  Totsuka Y, Higuchi T, Imai T, Nishikawa A, Nohmi T, Kato T, Masuda S, Kinae N, Hiyoshi K, Ogo S, Kawanishi M, Yagi T, Ichinose T, Fukumori N, Watanabe M, Sugimura T, Wakabayashi K.  Genotoxicity of nano/microparticles in in vitro micronuclei, in vivo comet and mutation assay systems  Part Fibre Toxicol  2009  6:23  PubMed ID: 19725983   DOI: 10.1186/1743-8977-6-23
8436  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents of propolis from Myanmar and their structure-activity relationship.  Biol. Pharm. Bull.  2009  32:2075-8  PubMed ID: 19952433   DOI: 10.1248/bpb.32.2075
8489  Matsuzawa Y, Kiuchi Y, Toyomura K, Matsumoto I, Nakamura H, Fujino H, Murayama T, Kawashima T.  Activation of cytosolic phospholipase A2alpha by epidermal growth factor (EGF) and phorbol ester in HeLa cells: different effects of inhibitors for EGF receptor, protein kinase C, Src, and C-Raf.  J. Pharmacol. Sci.  2009  111:182-92  PubMed ID: 19783865   DOI: 10.1254/jphs.09201fp
8509  Awale S, Miyamoto T, Linn TZ, Li F, Win NN, Tezuka Y, Esumi H, Kadota S.  Cytotoxic constituents of Soymida febrifuga from Myanmar.  J. Nat. Prod.  2009  72:1631-6  PubMed ID: 19689125   DOI: 10.1021/np9003323
8523  Tahara K, Sakai T, Yamamoto H, Takeuchi H, Hirashima N, Kawashima Y.  Improved cellular uptake of chitosan-modified PLGA nanospheres by A549 cells.  Int J Pharm  2009  382:198-204  PubMed ID: 19646519   DOI: 10.1016/j.ijpharm.2009.07.023
8596  Fukasawa C, Ishiwada N, Ogita J, Hishiki H, Kohno Y.  The effects of disodium cromoglycate on enhanced adherence of Haemophilus influenzae to A549 cells infected with respiratory syncytial virus.  Pediatr. Res.  2009  66:168-73  PubMed ID: 19390482   DOI: 10.1203/PDR.0b013e3181aa3b2e
8626  Iwakiri S, Mino N, Takahashi T, Sonobe M, Nagai S, Okubo K, Wada H, Date H, Miyahara R.  Higher expression of chemokine receptor CXCR7 is linked to early and metastatic recurrence in pathological stage I nonsmall cell lung cancer.  Cancer  2009  115:2580-93  PubMed ID: 19309748   DOI: 10.1002/cncr.24281
8659  Kawanami Y, Morimoto Y, Kim H, Nakamura T, Machida K, Kido T, Asonuma E, Yatera K, Yoshii C, Kido M.  Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells.  Respir. Res.  2009  10:8  PubMed ID: 19192276   DOI: 10.1186/1465-9921-10-8
8688  Yumi Motoyama,a Kanae Bekki,a Sang Woon Chung,a Ning Tang,b Takayuki Kameda,b. Akira Toriba,b Keiko Taguchi, Kazuichi Hayakawa  Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells  Journal of Health Science  2009  55:845-850    DOI: 10.1248/jhs.55.845
8698  Ozawa T, Miyata M, Nishimura M, Ando T, Ouyang Y, Ohba T, Shimokawa N, Ohnuma Y, Katoh R, Ogawa H, Nakao A.  Transforming growth factor-beta activity in commercially available pasteurized cow milk provides protection against inflammation in mice.  J. Nutr.  2009  139:69-75  PubMed ID: 19056655   DOI: 10.3945/jn.108.092528
18451  Hannachi Imen E, Nakamura M, Mie M, Kobatake E.  Construction of multifunctional proteins for tissue engineering: epidermal growth factor with collagen binding and cell adhesive activities  J Biotechnol  2009  139(1):19-25  PubMed ID: 18984018   DOI: 10.1016/j.jbiotec.2008.09.011
5877  Yamamoto H, Okumura K, Toshima S, Mukaisho K, Sugihara H, Hattori T, Kato M, Asano S.  FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues.  Biol Pharm Bull  2009  32(7):1148-54  PubMed ID: 19571376   DOI: 10.1248/bpb.32.1148
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
16646  Matsunami K, Otsuka H, Kondo K, Shinzato T, Kawahata M, Yamaguchi K, Takeda Y.  Absolute configuration of (+)-pinoresinol 4-O-[6''-O-galloyl]-beta-D-glucopyranoside, macarangiosides E, and F isolated from the leaves of Macaranga tanarius  Phytochemistry  2009  70(10):1277-85  PubMed ID: 19683319   DOI: 10.1016/j.phytochem.2009.07.020
18311  Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A.  Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter  J Nucl Med  2008  49(4):615-22  PubMed ID: 18344442   DOI: 10.2967/jnumed.107.048231
18334  Yoshikawa Y, Hirayasu H, Tsuzuki S, Fushiki T.  Granzyme A causes detachment of alveolar epithelial A549 cells accompanied by promotion of interleukin-8 release  Biosci Biotechnol Biochem  2008  72(9):2481-4  PubMed ID: 18776661   DOI: 10.1271/bbb.80362
13878  Tanaka Y, Goto K, Matsumoto Y, Ueoka R.  Remarkably high inhibitory effects of docosahexaenoic acid incorporated into hybrid liposomes on the growth of tumor cells along with apoptosis  Int J Pharm  2008  359(1-2):264-71  PubMed ID: 18511224   DOI: 10.1016/j.ijpharm.2008.03.045
16645  Li F, Awale S, Tezuka Y, Kadota S.  Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship  Bioorg Med Chem  2008  16(10):5434-40  PubMed ID: 18440233   DOI: 10.1016/j.bmc.2008.04.016
17238  Matsuda Y, Yamamoto T, Kudo M, Kawahara K, Kawamoto M, Nakajima Y, Koizumi K, Nakazawa N, Ishiwata T, Naito Z.  Expression and roles of lumican in lung adenocarcinoma and squamous cell carcinoma  Int J Oncol  2008  33(6):1177-85  PubMed ID: 19020750  
18608  Chen H, Zhang L, Jin Z, Jin E, Fujiwara M, Ghazizadeh M, Asoh S, Ohta S, Kawanami O.  Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats  Exp Mol Pathol  2007  83(3):377-84  PubMed ID: 17959170   DOI: 10.1016/j.yexmp.2007.08.016
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725   DOI: 10.1021/np0604681
9059  Y-C Jung, E Mizuki, T Akao, J-C Côté  Isolation and Characterization of a Novel Bacillus Thuringiensis Strain Expressing a Novel Crystal Protein With Cytocidal Activity Against Human Cancer Cells  J Appl Microbiol  2007  103 (1), 65-79  PubMed ID: 17584453   DOI: 10.1111/j.1365-2672.2006.03260.x
16537  Wakayama M, Abei M, Kawashima R, Seo E, Fukuda K, Ugai H, Murata T, Tanaka N, Hyodo I, Hamada H, Yokoyama KK.  E1A, E1B double-restricted adenovirus with RGD-fiber modification exhibits enhanced oncolysis for CAR-deficient biliary cancers  Clin Cancer Res  2007  13(10):3043-50  PubMed ID: 17505007   DOI: 10.1158/1078-0432.CCR-06-2103
6150  Ichwan SJ, Yamada S, Sumrejkanchanakij P, Ibrahim-Auerkari E, Eto K, Ikeda MA.  Defect in serine 46 phosphorylation of p53 contributes to acquisition of p53 resistance in oral squamous cell carcinoma cells.  Oncogene  2006  25(8):1216-24  PubMed ID: 16247456   DOI: 10.1038/sj.onc.1209158
6458  Misumi T, Tanaka T, Mikawa K, Nishina K, Morikawa O, Obara H.  Effects of sivelestat, a new elastase inhibitor, on IL-8 and MCP-1 production from stimulated human alveolar epithelial type II cells.  J Anesth  2006  20(3):159-65  PubMed ID: 16897233   DOI: 10.1007/s00540-006-0391-z
9054  Naoko Asaoka, Yasuko Tanaka, Tatsuya Sakai, Yutaka Fujii, Reiko Ohuchi, Masanobu Ohuchi  Low Growth Ability of Recent Influenza Clinical Isolates in MDCK Cells Is Due to Their Low Receptor Binding Affinities  Microbes Infect  2006  8 (2), 511-9  PubMed ID: 16300986   DOI: 10.1016/j.micinf.2005.08.006
14324  Gene expression profile changes correlating with radioresistance in human cell lines  Gene expression profile changes correlating with radioresistance in human cell lines  Int J Radiat Oncol Biol Phys  2006  65(1):234-4  PubMed ID: 16618578   DOI: 10.1016/j.ijrobp.2005.12.048
16074  Kawauchi S, Sato S, Morimoto Y, Kikuchi M.  Intracellular kinetics of ATX-S10.Na(II) and its correlation with photochemical reaction dynamics during a pulsed photosensitization process: effect of pulse repetition rate  J Biomed Opt  2006  11(1):014005  PubMed ID: 16526882   DOI: 10.1117/1.2160387
3413  Yamashita, Satoko, Katayama, Hideki, Saitoh, Hiroyuki, Akao, Tetsuyuki, Park, Yu Shin, Mizuki, Eiichi, Ohba, Michio, Ito, Akio  Typical Three-Domain Cry Proteins of Bacillus thuringiensis Strain A1462 Exhibit Cytocidal Activity on Limited Human Cancer Cells.  J Biochem  2005  138:663-72  PubMed ID: 16428294   DOI: 10.1093/jb/mvi177
2892  Katayama H, Yokota H, Akao T, Nakamura O, Ohba M, Mekada E, Mizuki E  Parasporin-1, a novel cytotoxic protein to human cells from non-insecticidal parasporal inclusions of Bacillus thuringiensis  J Biochem (Tokyo)  2005  137:17-25  PubMed ID: 15713879   DOI: 10.1093/jb/mvi003
3412  Okajima, Shuhei, Yamaguchi, Takeo, Sakai, Yasuyuki, Nakao, Shin-ichi  Regulation of cell adhesion using a signal-responsive membrane substrate.  Biotechnol Bioeng  2005  91:237-43  PubMed ID: 15892056   DOI: 10.1002/bit.20512
3409  Sato, Masamitsu, Takahashi, Kenji, Nagayama, Kazuhiro, Arai, Yasuhito, Ito, Nobue, Okada, Mitsumasa, Minna, John D, Yokota, Jun, Kohno, Takashi  Identification of chromosome arm 9p as the most frequent target of homozygous deletions in lung cancer.  Genes Chromosomes Cancer  2005  44:405-14  PubMed ID: 16114034   DOI: 10.1002/gcc.20253
3021  Fukumoto K, Yano Y, Virgona N, Hagiwara H, Sato H, Senba H, Suzuki K, Asano R, Yamada K, Yano T.  Peroxisome proliferator-activated receptor delta as a molecular target to regulate lung cancer cell growth.  FEBS Lett  2005  579(17):3829-36  PubMed ID: 15978581   DOI: 10.1016/j.febslet.2005.06.004
3022  Yano Y, Satoh H, Fukumoto K, Kumadaki I, Ichikawa T, Yamada K, Hagiwara K, Yano T.  Induction of cytotoxicity in human lung adenocarcinoma cells by 6-O-carboxypropyl-alpha-tocotrienol, a redox-silent derivative of alpha-tocotrienol.  Int J Cancer  2005  115(5):839-46  PubMed ID: 15723336   DOI: 10.1002/ijc.20809
9048  Shiro Okumura, Hiroyuki Saitoh, Tomoyuki Ishikawa, Naoya Wasano, Satoko Yamashita, Ken-Ichi Kusumoto, Tetsuyuki Akao, Eiichi Mizuki, Michio Ohba, Kuniyo Inouye  Identification of a Novel Cytotoxic Protein, Cry45Aa, From Bacillus Thuringiensis A1470 and Its Selective Cytotoxic Activity Against Various Mammalian Cell Lines  J Agric Food Chem  2005  53 (16), 6313-8  PubMed ID: 16076112   DOI: 10.1021/jf0506129
16489  Seike M, Kondo T, Fujii K, Okano T, Yamada T, Matsuno Y, Gemma A, Kudoh S, Hirohashi S.  Proteomic signatures for histological types of lung cancer  Proteomics  2005  5(11):2939-48  PubMed ID: 15996008   DOI: 10.1002/pmic.200401166
2894  Ito, Akio, Sasaguri, Yasuyuki, Kitada, Sakae, Kusaka, Yoshitomo, Kuwano, Kyoko, Masutomi, Kenjiro, Mizuki, Eiichi, Akao, Tetsuyuki, Ohba, Michio  A Bacillus thuringiensis crystal protein with selective cytocidal action to human cells.  J Biol Chem  2004  279:21282-6  PubMed ID: 15026424   DOI: 10.1074/jbc.M401881200
2708  Nanda K, Miyoshi N, Nakamura Y, Shimoji Y, Tamura Y, Nishikawa Y, Uenakai K, Kohno H, Tanaka T.  Extract of vinegar "Kurosu" from unpolished rice inhibits the proliferation of human cancer cells.  J. Exp. Clin. Cancer Res.  2004  23:69-75  PubMed ID: 15149153  
5416  Araki K, Hashimoto K, Ardyanto TD, Osaki M, Shomori K, Nakamura H, Ito H.  Co-expression of Cox-2 and EGFR in stage I human bronchial adenocarcinomas.  Lung Cancer  2004  45(2):161-9  PubMed ID: 15246187   DOI: 10.1016/j.lungcan.2004.01.013
2931  Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, KeQin X, Masuda A, Takahashi T, Kitamura H.  K-ras gene mutation enhances motility of immortalized airway cells and lung adenocarcinoma cells via Akt activation: possible contribution to non-invasive expansion of lung adenocarcinoma.  Am J Pathol  2004  164(1):91-100  PubMed ID: 14695323   DOI: 10.1016/S0002-9440(10)63100-8
3191  Akasaki K1, Nakamura N, Tsukui N, Yokota S, Murata S, Katoh R, Michihara A, Tsuji H, Marques ET Jr, August JT.  Human dendritic cell lysosome-associated membrane protein expressed in lung type II pneumocytes.  Arch Biochem Biophys  2004  425(2):147-57  PubMed ID: 15111122   DOI: 10.1016/j.abb.2004.02.042
3333  Kawauchi S, Sato S, Morimoto Y, Kikuchi M.  Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation time.  Photochem Photobiol  2004  80(2):216-23  PubMed ID: 15244505   DOI: 10.1562/2004-03-27-RA-125
9043  Hironaga Kamiyama, Kunikazu Kurosaki, Masanori Kurimoto, Toyomasa Katagiri, Yusuke Nakamura, Masahiko Kurokawa, Hitoshi Sato, Shunro Endo, Kimiyasu Shiraki  Herpes Simplex Virus-Induced, Death Receptor-Dependent Apoptosis and Regression of Transplanted Human Cancers  Cancer Sci  2004  95 (12), 990-8  PubMed ID: 15596049   DOI: 10.1111/j.1349-7006.2004.tb03188.x
12847  Ishii T, Teramoto S, Matsuse T.  GSTP1 affects chemoresistance against camptothecin in human lung adenocarcinoma cells  Cancer Lett  2004  216(1):89-102  PubMed ID: 15500952   DOI: 10.1016/j.canlet.2004.05.018
16491  Nakanishi H, Suda T, Katoh M, Watanabe A, Igishi T, Kodani M, Matsumoto S, Nakamoto M, Shigeoka Y, Okabe T, Oshimura M, Shimizu E.  Loss of imprinting of PEG1/MEST in lung cancer cell lines  Oncol Rep  2004  12(6):1273-8  PubMed ID: 15547750  
16648  Konishi J, Yamazaki K, Yokouchi H, Shinagawa N, Iwabuchi K, Nishimura M.  The characteristics of human NKT cells in lung cancer--CD1d independent cytotoxicity against lung cancer cells by NKT cells and decreased human NKT cell response in lung cancer patients  Hum Immunol  2004  65(11):1377-88  PubMed ID: 15556688   DOI: 10.1016/j.humimm.2004.09.003
18706  Simamura E, Hirai K, Shimada H, Pan J, Koyama J.  Mitochondrial damage prior to apoptosis in furanonaphthoquinone treated lung cancer cells  Cancer Detect Prev  2003  27(1):5-13  PubMed ID: 12600411   DOI: 10.1016/s0361-090x(02)00174-5
2659  Ma K, Araki K, Ichwan SJ, Suganuma T, Tamamori-Adachi M, Ikeda MA.  E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.  Mol Cancer Res  2003  1(6):438-44  PubMed ID: 12692263  
6401  Tsuchiya Y, Nakajima M, Itoh S, Iwanari M, Yokoi T.  Expression of aryl hydrocarbon receptor repressor in normal human tissues and inducibility by polycyclic aromatic hydrocarbons in human tumor-derived cell lines.  Toxicol Sci  2003  72(2):253-9  PubMed ID: 12655030   DOI: 10.1093/toxsci/kfg022
3594  Igishi T, Mikami M, Murakami K, Matsumoto S, Shigeoka Y, Nakanishi H, Yasuda K, Gutkind JS, Hitsuda Y, Shimizu E.  Enhancement of cisplatin-induced cytotoxicity by ROCK inhibitor through suppression of focal adhesion kinase-independent mechanism in lung carcinoma cells.  Int J Oncol  2003  23(4):1079-85  PubMed ID: 12963988  
3592  Fukuhara H, Masuda M, Yageta M, Fukami T, Kuramochi M, Maruyama T, Kitamura T, Murakami Y.  Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg.  Oncogene  2003  22(40):6160-5  PubMed ID: 13679854   DOI: 10.1038/sj.onc.1206744
9039  Masako Tanabe, Mitsue Kurita-Taniguchi, Kaoru Takeuchi, Makoto Takeda, Minoru Ayata, Hisashi Ogura, Misako Matsumoto, Tsukasa Seya  Mechanism of Up-Regulation of Human Toll-like Receptor 3 Secondary to Infection of Measles Virus-Attenuated Strains  Biochem Biophys Res Commun  2003  311 (1), 39-48  PubMed ID: 14575692   DOI: 10.1016/j.bbrc.2003.09.159
14424  Kajiwara Y, Yamasaki F, Hama S, Yahara K, Yoshioka H, Sugiyama K, Arita K, Kurisu K.  Expression of survivin in astrocytic tumors: correlation with malignant grade and prognosis  Cancer  2003  97(4):1077-83  PubMed ID: 12569609   DOI: 10.1002/cncr.11122
3020  Yano T, Zissel G, Muller-Qernheim J, Jae Shin S, Satoh H, Ichikawa T.  Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3.  FEBS Lett  2002  518(1-3):154-8  PubMed ID: 11997037   DOI: 10.1016/s0014-5793(02)02689-3
6399  Iwanari M, Nakajima M, Kizu R, Hayakawa K, Yokoi T.  Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences.  Arch Toxicol  2002  76(5-6):287-98  PubMed ID: 12107646   DOI: 10.1007/s00204-002-0340-z
16535  Matsuoka K, Isowa N, Yoshimura T, Liu M, Wada H.  Green tea polyphenol blocks h(2)o(2)-induced interleukin-8 production from human alveolar epithelial cells  Cytokine  2002  18(5):266-73  PubMed ID: 12161102   DOI: 10.1006/cyto.2002.1038
16609  Nagaoka T, Banskota AH, Tezuka Y, Saiki I, Kadota S.  Selective antiproliferative activity of caffeic acid phenethyl ester analogues on highly liver-metastatic murine colon 26-L5 carcinoma cell line  Bioorg Med Chem  2002  10(10):3351-9  PubMed ID: 12150882   DOI: 10.1016/s0968-0896(02)00138-4
16972  Nahoko Nakano, Ryoji Nagai, Kaori Fukuhara, Tamami Sakamoto, Nobuaki Eto, Seikoh Horiuchi  Expression of a novel AGE-receptor on A549 cells  International Congress Series  2002  1245:119-124    DOI: 10.1016/s0531-5131(02)00923-8
17297  Fujimoto N, Sueoka N, Sueoka E, Okabe S, Suganuma M, Harada M, Fujiki H.  Lung cancer prevention with (-)-epigallocatechin gallate using monitoring by heterogeneous nuclear ribonucleoprotein B1  Int J Oncol  2002  20(6):1233-9  PubMed ID: 12012004  
5404  Simamura E, Hirai KI, Shimada H, Koyama J.  Apoptosis and epithelial phagocytosis in mitomycin C-treated human pulmonary adenocarcinoma A549 cells.  Tissue Cell  2001  33:161-8  PubMed ID: 11392669   DOI: 10.1054/tice.2000.0167
5553  Kobayashi H, Higashiyama M, Minamigawa K, Tanisaka K, Takano T, Yokouchi H, Kodama K, Hata T.  Examination of in vitro chemosensitivity test using collagen gel droplet culture method with colorimetric endpoint quantification.  Jpn J Cancer Res  2001  92(2):203-10  PubMed ID: 11223550   DOI: 10.1111/j.1349-7006.2001.tb01083.x
3775  Ishibashi Y, Relman DA, Nishikawa A.  Invasion of human respiratory epithelial cells by Bordetella pertussis: possible role for a filamentous hemagglutinin Arg-Gly-Asp sequence and alpha5beta1 integrin.  Microb Pathog  2001  30(5):279-88  PubMed ID: 11373122   DOI: 10.1006/mpat.2001.0432
6400  Hatano H, Kawashima H, Ogose A, Hotta T, Endo N.  A PCR-ELISA assay for the detection of disseminated osteosarcoma cells in a mouse metastatic model.  J Orthop Sci  2001  6(3):269-75  PubMed ID: 11484122   DOI: 10.1007/s007760100046
9143  M Kuramochi, H Fukuhara, T Nobukuni, T Kanbe, T Maruyama, H P Ghosh, M Pletcher, M Isomura, M Onizuka, T Kitamura, T Sekiya, R H Reeves, Y Murakami  TSLC1 Is a Tumor-Suppressor Gene in Human Non-Small-Cell Lung Cancer  Nat Genet  2001  27 (4), 427-30  PubMed ID: 11279526   DOI: 10.1038/86934
13875  Satoh JI, Kuroda Y.  Alpha-synuclein expression is up-regulated in NTera2 cells during neuronal differentiation but unaffected by exposure to cytokines and neurotrophic factors  Parkinsonism Relat Disord  2001  8(1):7-17  PubMed ID: 11472875   DOI: 10.1016/s1353-8020(00)00075-4
5968  Satoh J, Kuroda Y.  Beta-catenin expression in human neural cell lines following exposure to cytokines and growth factors.  Neuropathology  2000  20(2):113-23  PubMed ID: 10935448   DOI: 10.1046/j.1440-1789.2000.00293.x
16532  Hirota A, Taki S, Kawaii S, Yano M, Abe N.  1,1-Diphenyl-2-picrylhydrazyl radical-scavenging compounds from soybean miso and antiproliferative activity of isoflavones from soybean miso toward the cancer cell lines  Biosci Biotechnol Biochem  2000  64(5):1038-40  PubMed ID: 10879475   DOI: 10.1271/bbb.64.1038
18150  Kono T, Watanabe M, Koyama K, Kishimoto T, Fukushima S, Sugimura T, Wakabayashi K.  Cytotoxic activity of pierisin, from the cabbage butterfly, Pieris rapae, in various human cancer cell lines  Cancer Lett  1999  137(1):75-81  PubMed ID: 10376796   DOI: 10.1016/s0304-3835(98)00346-2
6454  Asano M, Yukita A, Suzuki H.  Wide spectrum of antitumor activity of a neutralizing monoclonal antibody to human vascular endothelial growth factor.  Jpn J Cancer Res  1999  90(1):93-100  PubMed ID: 10076571   DOI: 10.1111/j.1349-7006.1999.tb00671.x
9026  H Uchida, N Kiyokawa, T Taguchi, H Horie, J Fujimoto, T Takeda  Shiga Toxins Induce Apoptosis in Pulmonary Epithelium-Derived Cells  Infect Dis  1999  180 (6), 1902-11  PubMed ID: 10558947   DOI: 10.1086/315131
16536  Mori N, Oishi K, Sar B, Mukaida N, Nagatake T, Matsushima K, Yamamoto N.  Essential role of transcription factor nuclear factor-kappaB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aeruginosa in respiratory epithelial cells  Infect Immun  1999  67(8):3872-8  PubMed ID: 10417151   DOI: 10.1128/IAI.67.8.3872-3878.1999
1505  Shiraishi M, Chuu YH, Sekiya T.  Isolation of DNA fragments associated with methylated CpG islands in human adenocarcinomas of the lung using a methylated DNA binding column and denaturing gradient gel electrophoresis  Proc Natl Acad Sci U S A  1999  96(6):2913-8  PubMed ID: 10077611   DOI: 10.1073/pnas.96.6.2913
2747  Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M, Takemura Y, Ju-ichi M, Ito C, Furukawa H.  The antiproliferative effect of acridone alkaloids on several cancer cell lines  J Nat Prod  1999  62(4):587-9  PubMed ID: 10217715   DOI: 10.1021/np980504z
13873  Satoh J, Kurohara K, Yukitake M, Kuroda Y.  Interleukin-15, a T-cell growth factor, is expressed in human neural cell lines and tissues  J Neurol Sci  1998  155(2):170-7  PubMed ID: 9562262   DOI: 10.1016/s0022-510x(97)00310-9
9017  A Tada, H Kato, K Takenaga, S Hasegawa  Transforming Growth Factor beta1 Increases the Expressions of High Molecular Weight Tropomyosin Isoforms and Vinculin and Suppresses the Transformed Phenotypes in Human Lung Carcinoma Cells  Cancer Lett  1997  121 (1), 31-7  PubMed ID: 9459171   DOI: 10.1016/s0304-3835(97)00319-4
17239  Lin-Shu Liu, Shu-Qin Liu, Steven Y Ng, Michael Froix, Tadao Ohno, Jorge Heller  Controlled release of interleukin-2 for tumour immunotherapy using alginate/chitosan porous microspheres  Journal of Controlled Release  1997  43:65-74    DOI: 10.1016/s0168-3659(96)01471-x
17240  Hiroko Isoda, Tadaatsu Nakahara  Antiproliferative effect of polyol lipids, 3,5-dihydroxydecanoyl and 5-hydroxy-2-decenoyl esters of arabitol and mannitol on lung cancer cell line A549  Journal of Fermentation and Bioengineering  1997  84:403-406    DOI: 10.1016/s0922-338x(97)81999-x
2114  Honma M, Hayashi M, Ohno T, Mizusawa H, Saijo K, Sofuni T.  Heterogeneity of the Y chromosome following long-term culture of the human lung cancer cell line A549.  In Vitro Cell Dev Biol Anim  1996  32(5):262-4  PubMed ID: 8792154   DOI: 10.1007/BF02723057
17227  Osada H, Kono T, Miwa K, Yamada C.  Phorbol-ester-stimulated human lymphoid cell lines produce a plasminogen activator modulator inducing cell-bound urokinase-type plasminogen activator in malignant tumor cell lines  Int J Cancer  1996  65(2):178-85  PubMed ID: 8567114   DOI: 10.1002/(SICI)1097-0215(19960117)65:2<178::AID-IJC9>3.0.CO;2-W
17951  Isoda H, Shinmoto H, Matsumura M, Nakahara T.  Succinoyl trehalose lipid induced differentiation of human monocytoid leukemic cell line U937 into monocyte-macrophages  Cytotechnology   1995  19(1):79-88  PubMed ID: 8987500   DOI: 10.1007/BF00749758
17968  Igarashi K, Koga K, He Y, Shimogori T, Ekimoto H, Kashiwagi K, Shirahata A.  Inhibition of the growth of various human and mouse tumor cells by 1,15-bis(ethylamino)-4,8,12-triazapentadecane  Cancer Res  1995  55(12):2615-9  PubMed ID: 7780977  
3751  Kobayashi S, Kondo S, Juni K.  Permeability of peptides and proteins in human cultured alveolar A549 cell monolayer.  Pharm Res  1995  12(8):1115-9  PubMed ID: 7494821   DOI: 10.1023/a:1016295406473
1901  Liu SQ, Shiba R, Kim BS, Saijo K, Ohno T.  Long-term serum/plasma-free culture of human cytotoxic T lymphocytes i  Cancer Immunol Immunother  1994  39(5):279-85  PubMed ID: 7987858   DOI: 10.1007/BF01519979
1902  Shu Qin Liu, Kaoru Saijo, Makoto Kodama, Tadao Ohno  Intelligent matrices for tumor-specific cytotoxic T lymphocytes  Materials Science and Engineering: C  1994  2:61-65    DOI: 10.1016/0928-4931(94)90030-2



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