Cell No. : Cell Name TDC0003 : PDT-LUAD#43  update : 2025/04/15
Comment			Currently not ready. Cancer organoid cell line.
Comment from the depositor			An organoid derived from malignant pleural effusion of a lung cancer patient with acquired resistance to EGFR TKIs (tyrosine kinase inhibitors). The organoid carried EGFR^(L858R)/RB1^(E737*).
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			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Expected time	Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
		IPR	Kawasaki Medical School
		Depositor	FUKAZAWA, Takuya
		Originator	FUKAZAWA, Takuya
Reference information		Reference	3
		User's Publication	0

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Reference

17019  Yokota E, Iwai M, Yukawa T, Yoshida M, Naomoto Y, Haisa M, Monobe Y, Takigawa N, Guo M, Maeda Y, Fukazawa T, Yamatsuji T.  Clinical application of a lung cancer organoid (tumoroid) culture system  NPJ Precis Oncol  2021  5(1):29  PubMed ID: 33846488   DOI: 10.1038/s41698-021-00166-3

17020  Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans SJ, van Zon JS, Boj SF, Vries RG, Beekman JM, Clevers H.  Long-termLong-term expanding human airway organoids for disease modeling expanding human airway organoids for disease modeling  EMBO J  2019  38(4):e100300  PubMed ID: 30643021   DOI: 10.15252/embj.2018100300

17021  Kim M, Mun H, Sung CO, Cho EJ, Jeon HJ, Chun SM, Jung DJ, Shin TH, Jeong GS, Kim DK, Choi EK, Jeong SY, Taylor AM, Jain S, Meyerson M, Jang SJ.  Patient-derived lung cancer organoids as in vitro cancer models for therapeutic screening  Nat Commun  2019  10(1):3991  PubMed ID: 31488816   DOI: 10.1038/s41467-019-11867-6

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