Cell No. : Cell Name RCB6068 : HSAEC_4T53RD_clone-2  update : 2025/03/12
Comment			Currently not ready.
Comment from the depositor			Transformed cell clone established from normal human small airway epithelial cells (HSAEC) by introducing hTERT, Cdk4, p53 dominant negative mutan, KRAS G12V and Cyclin D1.
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			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Expected time	Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
Reference information		Reference	2
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Reference

22590  Sasai K, Takao-Rikitsu E, Sukezane T, Yanagita E, Nakagawa H, Itoh-Yagi M, Izumi Y, Itoh T, Akagi T.  Engineering cancer stem-like cells from normal human lung epithelial cells.  PLoS One  2017  12(4):e0175147  PubMed ID: 28380052   DOI: 10.1371/journal.pone.0175147

22589  Sasai K, Sukezane T, Yanagita E, Nakagawa H, Hotta A, Itoh T, Akagi T.  Oncogene-mediated human lung epithelial cell transformation produces adenocarcinoma phenotypes in vivo.  Cancer Res  2011  71(7):2541-9  PubMed ID: 21447735   DOI: 10.1158/0008-5472.CAN-10-2221

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