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細胞番号 : 細胞名
RCB5994 : RE-3B9  update : 2025/06/27
細胞特性(Comment:英)Currently not ready.
細胞特性(日)未整備。
細胞特性(寄託者記述:英)Hybridoma clone secreting the CR-50 antibody (function-blocking antibody against Reelin)
細胞特性(寄託者記述:日)リーリンに対する機能阻害モノクローナル抗体 CR-50 を産生するハイブリドーマである。
使用条件(英)
使用条件(日)
備考(英)
備考(日)
提供申込書類(英)
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日)
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 提供開始までの期間 利用希望があれば可及的速やかに整備に着手します。詳細は cellkitaku.brc@riken.jp までお問い合わせください。
知的財産権 Keio University School of Medicine (Japan)
寄託者 NAKAJIMA, Kazunori
文献情報 Reference(英) 20件
Reference(日) 0件
利用者成果(英) 0件
利用者成果(日) 0件

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Reference(英)
22955  Kohno T, Honda T, Kubo K, Nakano Y, Tsuchiya A, Murakami T, Banno H, Nakajima K, Hattori M.  Importance of Reelin C-terminal region in the development and maintenance of the postnatal cerebral cortex and its regulation by specific proteolysis.  J Neurosci  2015  35(11):4776-87  PubMed ID: 25788693   DOI: 10.1523/JNEUROSCI.4119-14.2015
22954  Sekine K, Kawauchi T, Kubo K, Honda T, Herz J, Hattori M, Kinashi T, Nakajima K.  Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1.  Neuron  2012  76(2):353-69  PubMed ID: 23083738   DOI: 10.1016/j.neuron.2012.07.020
22953  Kubo K, Honda T, Tomita K, Sekine K, Ishii K, Uto A, Kobayashi K, Tabata H, Nakajima K.  Ectopic Reelin induces neuronal aggregation with a normal birthdate-dependent "inside-out" alignment in the developing neocortex.  J Neurosci  2010  30(33):10953-66  PubMed ID: 20720102   DOI: 10.1523/JNEUROSCI.0486-10.2010
22952  Nakano Y, Kohno T, Hibi T, Kohno S, Baba A, Mikoshiba K, Nakajima K, Hattori M.  The extremely conserved C-terminal region of Reelin is not necessary for secretion but is required for efficient activation of downstream signaling.  J Biol Chem  2007  282(28):20544-52  PubMed ID: 17504759   DOI: 10.1074/jbc.M702300200
22951  Soda T, Nakashima R, Watanabe D, Nakajima K, Pastan I, Nakanishi S.  Segregation and coactivation of developing neocortical layer 1 neurons.  J Neurosci  2003  23(15):6272-9  PubMed ID: 12867512   DOI: 10.1523/JNEUROSCI.23-15-06272.2003
22950  Kubo K, Mikoshiba K, Nakajima K.  Secreted Reelin molecules form homodimers.  Neurosci Res  2002  43(4):381-8  PubMed ID: 12135781   DOI: 10.1016/s0168-0102(02)00068-8
22949  Tabata H, Nakajima K.  Efficient in utero gene transfer system to the developing mouse brain using electroporation: visualization of neuronal migration in the developing cortex.  Neuroscience  2001  103(4):865-72  PubMed ID: 11301197   DOI: 10.1016/s0306-4522(01)00016-1
22947  Yip JW, Yip YP, Nakajima K, Capriotti C.  Reelin controls position of autonomic neurons in the spinal cord.  Proc Natl Acad Sci USA  2000  97(15):8612-6  PubMed ID: 10880573   DOI: 10.1073/pnas.150040497
22948  Utsunomiya-Tate N, Kubo K, Tate S, Kainosho M, Katayama E, Nakajima K, Mikoshiba K.  Reelin molecules assemble together to form a large protein complex, which is inhibited by the function-blocking CR-50 antibody.  Proc Natl Acad Sci USA  2000  97(17):9729-34  PubMed ID: 10920200   DOI: 10.1073/pnas.160272497
22945  Fatemi SH, Emamian ES, Kist D, Sidwell RW, Nakajima K, Akhter P, Shier A, Sheikh S, Bailey K.  Defective corticogenesis and reduction in Reelin immunoreactivity in cortex and hippocampus of prenatally infected neonatal mice.  Mol Psychiatry  1999  4(2):145-54  PubMed ID: 10208446   DOI: 10.1038/sj.mp.4000520
22946  Alvarez-Dolado M, Ruiz M, Del Río JA, Alcántara S, Burgaya F, Sheldon M, Nakajima K, Bernal J, Howell BW, Curran T, Soriano E, Muñoz A.  Thyroid hormone regulates reelin and dab1 expression during brain development.  J Neurosci  1999  19(16):6979-93  PubMed ID: 10436054   DOI: 10.1523/JNEUROSCI.19-16-06979.1999
22944  Rice DS, Sheldon M, D'Arcangelo G, Nakajima K, Goldowitz D, Curran T.  Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain.  Development  1998  125(18):3719-29  PubMed ID: 9716537   DOI: 10.1242/dev.125.18.3719
22938  D'Arcangelo G, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Curran T.  Reelin is a secreted glycoprotein recognized by the CR-50 monoclonal antibody.  J Neurosci.  1997  17(1):23-31  PubMed ID: 8987733   DOI: 10.1523/JNEUROSCI.17-01-00023.1997
22939  Del Río JA, Heimrich B, Borrell V, Förster E, Drakew A, Alcántara S, Nakajima K, Miyata T, Ogawa M, Mikoshiba K, Derer P, Frotscher M, Soriano E.  A role for Cajal-Retzius cells and reelin in the development of hippocampal connections.  Nature  1997  385(6611):70-4  PubMed ID: 8985248   DOI: 10.1038/385070a0
22940  Miyata T, Nakajima K, Mikoshiba K, Ogawa M.  Regulation of Purkinje cell alignment by reelin as revealed with CR-50 antibody.  J Neurosci  1997  17(10):3599-609  PubMed ID: 9133383   DOI: 10.1523/JNEUROSCI.17-10-03599.1997
22941    Disruption of hippocampal development in vivo by CR-50 mAb against reelin.  Proc Natl Acad Sci USA  1997  94(15):8196-201  PubMed ID: 9223338   DOI: 10.1073/pnas.94.15.8196
22942  Yoneshima H, Nagata E, Matsumoto M, Yamada M, Nakajima K, Miyata T, Ogawa M, Mikoshiba K.  A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/reelin.  Neurosci Res  1997  29(3):217-23  PubMed ID: 9436647   DOI: 10.1016/s0168-0102(97)00088-6
22943  de Bergeyck V, Nakajima K, Lambert de Rouvroit C, Naerhuyzen B, Goffinet AM, Miyata T, Ogawa M, Mikoshiba K.  A truncated Reelin protein is produced but not secreted in the 'Orleans' reeler mutation (Reln[rl-Orl]).  Mol Brain Res  1997  50(1-2):85-90  PubMed ID: 9406921   DOI: 10.1016/s0169-328x(97)00166-6
22937  Miyata T, Nakajima K, Aruga J, Takahashi S, Ikenaka K, Mikoshiba K, Ogawa M.  Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.  J Comp Neurol.  1996  372(2):215-228  PubMed ID: 8863127   DOI: 10.1002/(SICI)1096-9861(19960819)372:2<215::AID-CNE5>3.0.CO;2-6
22936  Ogawa M, Miyata T, Nakajima K, Yagyu K, Seike M, Ikenaka K, Yamamoto H, Mikoshiba K.  The reeler gene-associated antigen on Cajal-Retzius neurons is a crucial molecule for laminar organization of cortical neurons.  Neuron  1995  14(5):899-912  PubMed ID: 7748558   DOI: 10.1016/0896-6273(95)90329-1

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