Cell No. : Cell Name
RCB5950 : 2C10
update : 2024/07/18
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| Comment | Currently not ready. |
| Comment from the depositor | 2C10 produces monoclonal antibody which binds to dsDNA, but not to ssDNA. |
| Terms and conditions | |
| Remarks | |
| Order Form |
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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Basic information
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Expected time |
Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
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| IPR |
Tokyo Medical and Dental University (Japan)
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| Depositor |
HOSHI, Osamu
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| Originator |
KUBOTA, Tetsuo
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| Reference information |
Reference |
9
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| User's Publication |
0
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| Reference |
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19163
Saito M, Makino Y, Inoue K, Watanabe Y, Hoshi O, Kubota T.
Anti-DNA antibodies cross-reactive with β2-glycoprotein I induce monocyte tissue factor through the TLR9 pathway
Immunol Med
2021
44(2):124-135
PubMed ID: 32701417
DOI: 10.1080/25785826.2020.1796285
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19162
Inoue K, Ishizawa M, Kubota T.
Monoclonal anti-dsDNA antibody 2C10 escorts DNA to intracellular DNA sensors in normal mononuclear cells and stimulates secretion of multiple cytokines implicated in lupus pathogenesis
Clin Exp Immunol
2020
199(2):150-162
PubMed ID: 31604370
DOI: 10.1111/cei.13382
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19161
Virachith S, Saito M, Watanabe Y, Inoue K, Hoshi O, Kubota T.
Anti-β2 -glycoprotein I antibody with DNA binding activity enters living monocytes via cell surface DNA and induces tissue factor expression
Clin Exp Immunol
2019
195(2):167-178
PubMed ID: 30368780
DOI: 10.1111/cei.13229
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19159
Lu Q, Kanai Y, Kubota T.
The emergence of anti-dsDNA antibodies precedes nucleosome-specific antibodies in MRL/lpr and MRL/+ mice
J Med Dent Sci
2003
50(1):9-15
PubMed ID: 12715914
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19158
Satake F, Watanabe N, Miyasaka N, Kanai Y, Kubota T.
Induction of anti-DNA antibodies by immunization with anti-DNA antibodies: mechanism and characterization
Lupus
2000
9(7):489-97
PubMed ID: 11035413
DOI: 10.1177/096120330000900703
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2331
Kubota T, Watanabe N, Kanai Y, Stollar BD.
Enhancement of oxidative cleavage of DNA by the binding sites of two anti-double-stranded DNA antibodies
J Biol Chem
1996
271(11):6555-61
PubMed ID: 8626460
DOI: 10.1074/jbc.271.11.6555
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2329
Kubota T, Kanai Y, Miyasaka N.
Interpretation of the cross-reactivity of anti-DNA antibodies with cell surface proteins: the role of cell surface histones
Immunol Lett
1990
23(3):187-93
PubMed ID: 2307491
DOI: 10.1016/0165-2478(90)90190-2
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2328
Kanai Y, Kubota T.
A novel trait of naturally occurring anti-DNA antibodies: dissociation from immune complexes in neutral 0.3-0.5 M NaCl
Immunol Lett
1989
22(4):293-9
PubMed ID: 2628287
DOI: 10.1016/0165-2478(89)90168-5
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2327
Kubota T, Akatsuka T, Kanai Y.
A monoclonal anti-double stranded DNA antibody from an autoimmune MRL/Mp-lpr/lpr mouse: specificity and idiotype in serum immunoglobulins
Immunol Lett
1986
14(1):53-8
PubMed ID: 3492443
DOI: 10.1016/0165-2478(86)90020-9
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