Cell No. : Cell Name
RCB5684 : MDS92
update : 2025/01/20
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| Comment | Currently not ready. |
| Comment from the depositor | This cell line was established from the bone marrow of a patient with MDS. MDS92 cells proliferate slowly in the presence of IL-3 and the whole cells consist of immature blastic cell fraction and dysplastic neutrophil-like or macrophage-like differentiated cell fractions. MDS92 is a parental cell line of MDS-L, MDS-L-2007 and MDS-LGF. After a long -term culture, most cells may differentiate into mature cells and proliferate no longer in some cases, while immature cells may begin to expand like as leukemic transition in the other cases. |
| Terms and conditions | |
| Remarks | |
| Order Form |
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Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
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Basic information
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Expected time |
Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
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| Reference information |
Reference |
9
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| User's Publication |
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| Reference |
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17049
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ.
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia
Sci Adv
2022
8(7):eabl8952
PubMed ID: 35179961
DOI: 10.1126/sciadv.abl8952
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17048
Kida JI, Tsujioka T, Suemori SI, Okamoto S, Sakakibara K, Takahata T, Yamauchi T, Kitanaka A, Tohyama Y, Tohyama K.
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDS
Leukemia
2018
32(8):1846-1850
PubMed ID: 29955132
DOI: 10.1038/s41375-018-0189-7
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17047
Tsujioka T, Yokoi A, Uesugi M, Kishimoto M, Tochigi A, Suemori S, Tohyama Y, Tohyama K.
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines
Exp Hematol
2013
41(2):189-97
PubMed ID: 23085465
DOI: 10.1016/j.exphem.2012.10.006
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17046
Tsujioka T, Matsuoka A, Tohyama Y, Tohyama K.
Approach to new therapeutics: investigation by the use of MDS-derived cell lines
Curr Pharm Des
2012
18(22):3204-14
PubMed ID: 22571700
DOI: 10.2174/1381612811209023204
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17045
Drexler HG, Dirks WG, Macleod RA.
Many are called MDS cell lines: one is chosen
Leuk Res
2009
33(8):1011-6
PubMed ID: 19344951
DOI: 10.1016/j.leukres.2009.03.005
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17043
Tohyama K.
Human factor-dependent leukemia cell lines
Int J Hematol
1997
65(4):309-17
PubMed ID: 9195772
DOI: 10.1016/s0925-5710(96)00563-4
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17044
Yaguchi M, Miyazawa K, Katagiri T, Nishimaki J, Kizaki M, Tohyama K, Toyama K.
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acid
Leukemia
1997
11(6):779-87.
PubMed ID: 9177427
DOI: 10.1038/sj.leu.2400667
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17042
Tohyama K, Tohyama Y, Nakayama T, Ueda T, Nakamura T, Yoshida Y.
A novel factor-dependent human myelodysplastic cell line, MDS92, contains haemopoietic cells of several lineages
Br J Haematol
1995
91(4):795-9
PubMed ID: 8547120
DOI: 10.1111/j.1365-2141.1995.tb05391.x
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17041
Tohyama K, Tsutani H, Ueda T, Nakamura T, Yoshida Y.
Establishment and characterization of a novel myeloid cell line from the bone marrow of a patient with the myelodysplastic syndrome
Br J Haematol
1994
87(2):235-42
PubMed ID: 7947263
DOI: 10.1111/j.1365-2141.1994.tb04904.x
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