This cell line was established from the bone marrow of a patient with MDS. MDS92 cells proliferate slowly in the presence of IL-3 and the whole cells consist of immature blastic cell fraction and dysplastic neutrophil-like or macrophage-like differentiated cell fractions. MDS92 is a parental cell line of MDS-L, MDS-L-2007 and MDS-LGF. After a long -term culture, most cells may differentiate into mature cells and proliferate no longer in some cases, while immature cells may begin to expand like as leukemic transition in the other cases.
Terms and conditions
1) TheRECIPIENT of BIOLOGICAL RESOURCE shall obtain a priorcon sent on use of it from the DEVELOPER and DEPOSITOR. The RECIPIENT shall conclude a MTA with the depositor. 2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature (Leukemia 2018 32(8):1846-1850) designated by the DEPOSITOR is requested. 3) In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
Remarks
approver's address
×
English
Address
Kawasaki University of Medical Welfare Industry-Academia Collaboration and Intellectual Property Management Section 577 Matsushima, Kurashiki-city, Okayama 701-0192 JAPAN E-mail. s-renkei@med.kawasaki-m.ac.jp
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information
IPR
Kawasaki University of Medical Welfare (Japan)
Depositor
TOHYAMA, Kaoru
Originator
TOHYAMA, Kaoru
Year of deposit
2022
Cloning (depositor)
No
Animal
_human
< Mammals
Genus
Homo
Species
sapiens
Race
Japanese
Gender
Male
Age at sampling
54 years
Tissue
bone marrow
Primary focus
bone marrow
Disease name
myelodysplastic syndrome (MDS)
Tumor
MDS-EB1 stage from MDS-RS
Classification
cancer
Recombinant
non-recombinant
Year of origin
1991
Lifespan
unknown
Morphology
other
(mixture of immature cells and maturing myeloid cells)
Differentiation
Lifespan : unknown because the whole cells might differentiate gradually into mature cells under unkown culture conditions.
17049
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ.
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemiaSci Adv
2022
8(7):eabl8952
PubMed ID: 35179961
DOI: 10.1126/sciadv.abl8952
17048
Kida JI, Tsujioka T, Suemori SI, Okamoto S, Sakakibara K, Takahata T, Yamauchi T, Kitanaka A, Tohyama Y, Tohyama K.
An MDS-derived cell line and a series of its sublines serve as an in vitro model for the leukemic evolution of MDSLeukemia
2018
32(8):1846-1850
PubMed ID: 29955132
DOI: 10.1038/s41375-018-0189-7
17047
Tsujioka T, Yokoi A, Uesugi M, Kishimoto M, Tochigi A, Suemori S, Tohyama Y, Tohyama K.
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell linesExp Hematol
2013
41(2):189-97
PubMed ID: 23085465
DOI: 10.1016/j.exphem.2012.10.006
17046
Tsujioka T, Matsuoka A, Tohyama Y, Tohyama K.
Approach to new therapeutics: investigation by the use of MDS-derived cell linesCurr Pharm Des
2012
18(22):3204-14
PubMed ID: 22571700
DOI: 10.2174/1381612811209023204
17045
Drexler HG, Dirks WG, Macleod RA.
Many are called MDS cell lines: one is chosenLeuk Res
2009
33(8):1011-6
PubMed ID: 19344951
DOI: 10.1016/j.leukres.2009.03.005
17043
Tohyama K.
Human factor-dependent leukemia cell linesInt J Hematol
1997
65(4):309-17
PubMed ID: 9195772
DOI: 10.1016/s0925-5710(96)00563-4
17044
Yaguchi M, Miyazawa K, Katagiri T, Nishimaki J, Kizaki M, Tohyama K, Toyama K.
Vitamin K2 and its derivatives induce apoptosis in leukemia cells and enhance the effect of all-trans retinoic acidLeukemia
1997
11(6):779-87.
PubMed ID: 9177427
DOI: 10.1038/sj.leu.2400667
17042
Tohyama K, Tohyama Y, Nakayama T, Ueda T, Nakamura T, Yoshida Y.
A novel factor-dependent human myelodysplastic cell line, MDS92, contains haemopoietic cells of several lineagesBr J Haematol
1995
91(4):795-9
PubMed ID: 8547120
DOI: 10.1111/j.1365-2141.1995.tb05391.x
17041
Tohyama K, Tsutani H, Ueda T, Nakamura T, Yoshida Y.
Establishment and characterization of a novel myeloid cell line from the bone marrow of a patient with the myelodysplastic syndromeBr J Haematol
1994
87(2):235-42
PubMed ID: 7947263
DOI: 10.1111/j.1365-2141.1994.tb04904.x
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How_to_culture_MDS92.pdf