Cell No. : Cell Name RCB5347 : TDP2-TK6  update : 2022/09/06
Comment			Currently not ready.
Comment from the depositor			TK6 cells are one of the most commonly used human B lymphocyte-derived cell for cancer research. TDP2- disrupted TK6 cells.
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			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Expected time	Upon a request we will start preparation. Contact us: cellkitaku.brc@riken.jp
Reference information		Reference	6
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Reference

17846  Sasanuma H, Tsuda M, Morimoto S, Saha LK, Rahman MM, Kiyooka Y, Fujiike H, Cherniack AD, Itou J, Callen Moreu E, Toi M, Nakada S, Tanaka H, Tsutsui K, Yamada S, Nussenzweig A, Takeda S.  BRCA1 ensures genome integrity by eliminating estrogen-induced pathological topoisomerase II-DNA complexes  Proc Natl Acad Sci U S A  2018  115(45):E10642-E10651  PubMed ID: 30352856   DOI: 10.1073/pnas.1803177115

17839  Hoa NN, Shimizu T, Zhou ZW, Wang ZQ, Deshpande RA, Paull TT, Akter S, Tsuda M, Furuta R, Tsutsui K, Takeda S, Sasanuma H.  Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes  Mol Cell  2016  64(3):580-592  PubMed ID: 27814490   DOI: 10.1016/j.molcel.2016.10.011

17841  Marchand C, Abdelmalak M, Kankanala J, Huang SY, Kiselev E, Fesen K, Kurahashi K, Sasanuma H, Takeda S, Aihara H, Wang Z, Pommier Y.  Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2  ACS Chem Biol  2016  11(7):1925-33  PubMed ID: 27128689   DOI: 10.1021/acschembio.5b01047

279  Skopek TR, Liber HL, Penman BW, Thilly WG.  Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay  Biochem Biophys Res Commun  1978  84(2):411-6  PubMed ID: 214074   DOI: 10.1016/0006-291x(78)90185-7

281  Levy JA, Buell DN, Creech C, Hirshaut Y, Silverberg H.  Further characterization of the WI-L1 and WI-L2 lymphoblastoid lines  J Natl Cancer Inst  1971  46(3):647-54  PubMed ID: 4323138

280  Levy JA, Virolainen M, Defendi V.  Human lymphoblastoid lines from lymph node and spleen  Cancer  1968  22(3):517-24  PubMed ID: 5673231   DOI: 10.1002/1097-0142(196809)22:3<517::aid-cncr2820220305>3.0.co;2-a

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