The cells are fibroblasts prepared from embryos of the wild type mice (congenic (>96%) to C57BL/6J mice). They were immortalized by transfection with a plasmid encoding the SV40 large T antigen.
Terms and conditions
A prior written permission of the approver(Depositor) is necessary for any kind of use including academic use and for-profit use.
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
18864
Li ST, Hirayama H, Huang C, Matsuda T, Oka R, Yamasaki T, Kohda D, Suzuki T.
Hydrolytic activity of yeast oligosaccharyltransferase is enhanced when misfolded proteins accumulate in the endoplasmic reticulumFEBS J
2023
Nov 24
PubMed ID: 37997624
DOI: 10.1111/febs.17011
17476
Huang C, Suzuki T.
The occurrence of nonglycosylated forms of N-glycoprotein upon proteasome inhibition does not confirm cytosolic deglycosylationFEBS Lett
2020
594(9):1433-1442
PubMed ID: 31951015
DOI: 10.1002/1873-3468.13734
17477
Maynard JC, Fujihira H, Dolgonos GE, Suzuki T, Burlingame AL.
Cytosolic N-GlcNAc proteins are formed by the action of endo-β-N-acetylglucosaminidaseBiochem Biophys Res Commun
2020
530(4):719-724
PubMed ID: 32782141
DOI: 10.1016/j.bbrc.2020.06.127
17478
Fujihira H, Masahara-Negishi Y, Akimoto Y, Hirayama H, Lee HC, Story BA, Mueller WF, Jakob P, Clauder-Münster S, Steinmetz LM, Radhakrishnan SK, Kawakami H, Kamada Y, Miyoshi E, Yokomizo T, Suzuki T.
Liver-specific deletion of Ngly1 causes abnormal nuclear morphology and lipid metabolism under food stressBiochim Biophys Acta Mol Basis Dis
2020
1866(3):165588
PubMed ID: 31733337
DOI: 10.1016/j.bbadis.2019.165588
17479
Galeone A, Adams JM, Matsuda S, Presa MF, Pandey A, Han SY, Tachida Y, Hirayama H, Vaccari T, Suzuki T, Lutz CM, Affolter M, Zuberi A, Jafar-Nejad H.
Regulation of BMP4/Dpp retrotranslocation and signaling by deglycosylationElife . 2020 Jul 28;9:e55596
2020
9:e55596
PubMed ID: 32720893
DOI: 10.7554/eLife.55596
18862
Fermaintt CS, Sano K, Liu Z, Ishii N, Seino J, Dobbs N, Suzuki T, Fu YX, Lehrman MA, Matsuo I, Yan N.
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune responseNat Commun
2019
10(1):2377
PubMed ID: 31147550
DOI: 10.1038/s41467-019-10319-5
18861
Yang K, Huang R, Fujihira H, Suzuki T, Yan N.
N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1J Exp Med
2018
215(10):2600-2616
PubMed ID: 30135079
DOI: 10.1084/jem.20180783
18859
Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T,
Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor CytotoxicityACS Cent Sci
2017
1143-1155
PubMed ID: 29202016
DOI: 10.1021/acscentsci.7b00224
18860
Fujihira H, Masahara-Negishi Y, Tamura M, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T.
Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase genePLoS Genet
2017
13(4):e1006696
PubMed ID: 28426790
DOI: 10.1371/journal.pgen.1006696
18858
Harada Y, Huang C, Yamaki S, Dohmae N, Suzuki T.
Non-lysosomal Degradation of Singly Phosphorylated Oligosaccharides Initiated by the Action of a Cytosolic Endo-β-N-acetylglucosaminidaseJ Biol Chem
2016
291(15):8048-58
PubMed ID: 26858256
DOI: 10.1074/jbc.M115.685313
18856
Harada Y, Masahara-Negishi Y, Suzuki T.
Cytosolic-free oligosaccharides are predominantly generated by the degradation of dolichol-linked oligosaccharides in mammalian cellsGlycobiology
2014
25(11):1196-205
PubMed ID: 26206502
DOI: 10.1093/glycob/cwv055
13936
Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno-Horikawa Y, Nakano M, Asahi M, Takahashi M, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N.
Dysregulation of TGF-beta1 receptor activation leads to abnormal lung development and emphysema-like phenotype in core fucose-deficient miceProc Natl Acad Sci U S A
2005
102(44):15791-6
PubMed ID: 16236725
DOI: 10.1073/pnas.0507375102