| Reference |
|
20678
Ono K, Fujiwara T, Saito K, Nishizawa H, Takahashi N, Suzuki C, Ochi T, Kato H, Ishii Y, Onodera K, Ichikawa S, Fukuhara N, Onishi Y, Yokoyama H, Yamada R, Nakamura Y, Igarashi K, Harigae H.
Congenital sideroblastic anemia model due to ALAS2 mutation is susceptible to ferroptosis.
Sci Rep
2022
12(1):9024
PubMed ID: 35637209
|
|
20087
Ma Y, Liu S, Gao J, Chen C, Zhang X, Yuan H, Chen Z, Yin X, Sun C, Mao Y, Zhou F, Shao Y, Liu Q, Xu J, Cheng L, Yu D, Li P, Yi P, He J, Geng G, Guo Q, Si Y, Zhao H, Li H, Banes GL, Liu H, Nakamura Y, Kurita R, Huang Y, Wang X, Wang F, Fang G, Engel JD, Shi L, Zhang YE, Yu J.
Genome-wide analysis of pseudogenes reveals HBBP1's human-specific essentiality in erythropoiesis and implication in β-thalassemia.
Dev Cell
2021
56(4):478-493.e11
PubMed ID: 33476555
|
|
20294
Ma SP, Xi HR, Gao XX, Yang JM, Kurita R, Nakamura Y, Song XM, Chen HY, Lu DR.
Long noncoding RNA HBBP1 enhances γ-globin expression through the ETS transcription factor ELK1.
Biochem Biophys Res Commun
2021
552:157-163
PubMed ID: 33744764
|
|
15517
Papasavva PL, Papaioannou NY, Patsali P, Kurita R, Nakamura Y, Sitarou M, Christou S, Kleanthous M, Lederer CW.
Distinct miRNA Signatures and Networks Discern Fetal from Adult Erythroid Differentiation and Primary from Immortalized Erythroid Cells
Int J Mol Sci
2021
22(7):3626.
PubMed ID: 33807258
|
|
15638
King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, McGee B, Saunders TL, Kurita R, Nakamura Y, Engel JD, Reddy P, Khoriaty R.
SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II
Sci Adv
2021
7(48):eabj5293
PubMed ID: 34818036
|
|
16042
Yannis Hara, Dipti Gupta, Courtney Mercadante, Kim Alving, Yukio Nakamura, Sriram Krishnamoorthy, Alexandra Hicks, Melanie Demers
Heme-Regulated eIF2α Kinase (HRI) Inhibition Decreases PKR Activation in HUDEP2 Cells
Blood
2021
138:2035-2035
|
|
16066
Wessels MW, Cnossen MH, van Dijk TB, Gillemans N, Schmidt KLJ, van Lom K, Vinjamur DS, Coyne S, Kurita R, Nakamura Y, de Man SA, Pfundt R, Azmani Z, Brouwer RWW, Bauer DE, van den Hout MCGN, van IJcken WFJ, Philipsen S.
Molecular analysis of the erythroid phenotype of a patient with BCL11A haploinsufficiency
Blood Adv
2021
5(9):2339-2349
PubMed ID: 33938942
|
|
6747
Daniels DE, Downes DJ, Ferrer-Vicens I, Ferguson DCJ, Singleton BK, Wilson MC, Trakarnsanga K, Kurita R, Nakamura Y, Anstee DJ, Frayne J
Comparing the two leading erythroid lines BEL-A and HUDEP-2.
Haematologica
2020
105(8):e389-e394
PubMed ID: 31753923
|
|
6796
Balogh P, Adelman ER, Pluvinage JV, Capaldo BJ, Freeman KC, Singh S, Elagib KE, Nakamura Y, Kurita R, Sashida G, Zunder ER, Li H, Gru AA, Price EA, Schrier SL, Weissman IL, Figueroa ME, Pang WW, Goldfarb AN.
RUNX3 levels in human hematopoietic progenitors are regulated by aging and dictate erythroid-myeloid balance.
Haematologica
2020
105(4):905-913
PubMed ID: 31171641
|
|
8959
Liren Wang, Linxi Li, Yanlin Ma, Handan Hu 1, Qi Li, Yang Yang, Wenbang Liu, Shuming Yin, Wei Li, Bin Fu, Ryo Kurita, Yukio Nakamura, Mingyao Liu, Yongrong Lai, Dali Li
Reactivation of γ-Globin Expression Through Cas9 or Base Editor to Treat β-Hemoglobinopathies
Cell Res
2020
30 (3), 276-278
PubMed ID: 31911671
|
|
8964
Jun Zhan, Maria Johnson Irudayam, Yukio Nakamura, Ryo Kurita, Arthur W Nienhuis
High Level of Fetal-Globin Reactivation by Designed Transcriptional Activator-Like Effector
Blood Adv
2020
4 (4), 687-695
PubMed ID: 32084259
|
|
8969
Cristina Fugazza, Gloria Barbarani, Sudharshan Elangovan, Maria Giuseppina Marini, Serena Giolitto, Isaura Font-Monclus, Maria Franca Marongiu, Laura Manunza, John Strouboulis, Claudio Cantù, Fabio Gasparri, Silvia M L Barabino, Yukio Nakamura, Sergio Ottolenghi, Paolo Moi, Antonella Ellena Ronchi
The Coup-TFII Orphan Nuclear Receptor Is an Activator of the γ-Globin Gene
Haematologica
2020
106(2):474-482
PubMed ID: 32107331
|
|
8970
Leslie Weber, Giacomo Frati, Tristan Felix, Giulia Hardouin, Antonio Casini, Clara Wollenschlaeger, Vasco Meneghini, Cecile Masson, Anne De Cian, Anne Chalumeau, Fulvio Mavilio, Mario Amendola, Isabelle Andre-Schmutz, Anna Cereseto, Wassim El Nemer, Jean-Paul Concordet, Carine Giovannangeli, Marina Cavazzana, Annarita Miccio
Editing a γ-Globin Repressor Binding Site Restores Fetal Hemoglobin Synthesis and Corrects the Sickle Cell Disease Phenotype
Sci Adv
2020
6 (7), eaay9392
PubMed ID: 32095533
|
|
6743
Chung JE, Magis W, Vu J, Heo SJ, Wartiovaara K, Walters MC, Kurita R, Nakamura Y, Boffelli D, Martin DIK, Corn JE, DeWitt MA
CRISPR-Cas9 interrogation of a putative fetal globin repressor in human erythroid cells.
PLoS One
2019
14(1):e0208237
PubMed ID: 30645582
|
|
6744
Couch T, Murphy Z, Getman M, Kurita R, Nakamura Y, Steiner LA.
Human erythroblasts with c-Kit activating mutations have reduced cell culture costs and remain capable of terminal maturation.
Exp Hematol
2019
19-24.e4
PubMed ID: 31004744
|
|
6752
Svetlana Soboleva , Ryo Kurita, PhD , Fredrik Ek, PhD , Rita Alves , Roger Olsson, PhD , Yukio Nakamura, MD PhD , Kenichi Miharada, PhD
Identification of Potential Chemical Compounds Able to Trigger Enucleation of Immortalized Human Erythroid Cell Lines
Blood
2019
134 (Supplement_1): 951
|
|
6763
Ingrid Grazielle Sousa, BSc, MSc , Priscila Keiko Matsumoto Martin, PhD , Dulcinéia Martins de Albuquerque, BSc, PhD , Carolina Lanaro, BSc, PhD , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Fernando Ferreira Costa, MD PhD
Knockdown of HNF4A Gene Increases Fetal Hemoglobin Synthesis in Hudep-2
Blood
2019
134 (Supplement_1): 968
|
|
6768
Tohru Fujiwara, MD PhD , Chie Suzuki , Tetsuro Ochi , Koya Ono, MD , Kei Saito , Noriko Fukuhara, MD PhD , Yasushi Onishi, MD PhD , Hisayuki Yokoyama, MD PhD , Shinichi Fujimaki , Yukio Nakamura, MD PhD , Hideo Harigae, MD PhD
Characterization of Congenital Sideroblastic Anemia Model Due to ABCB7 Defects: How Do Defects in Iron-Sulfur Cluster Metabolism Lead to Ring Sideroblast Formation?
Blood
2019
134 (Supplement_1): 2232
|
|
6770
Melanie Demers, PhD , Sarah Sturtevant, BSc , Kevin Guertin, PhD , Dipti Gupta , Kunal Desai, MS , Benjamin Vieira, BS , Alexandra Hicks, PhD , Ayman Ismail, PhD , Yukio Nakamura, MD PhD , Bronner Goncalves, MD PhD , Giuseppe Di Caprio, PhD , Ethan Schonbrun, PhD , Scott Hansen, BS , Martin K. Safo, PhD , David K. Wood, PhD , John M. Higgins, MD PhD , David R. Light, PhD
MetAP2 Inhibition Modifies Hemoglobin S (HbS) to Delay Polymerization and Improve Blood Flow in Sickle Cell Disease
Blood
2019
134 (Supplement_1): 2260
|
|
6771
Dipti Gupta , Sarah Sturtevant, BSc , Benjamin Vieira, BS , Yukio Nakamura, MD PhD , Sriram Krishnamoorthy, PhD , Melanie Demers, PhD
Characterization of a Genetically Engineered HUDEP2 Cell Line Harboring a Sickle Cell Disease Mutation As a Potential Research Tool for Preclinical Sickle Cell Disease Drug Discovery
Blood
2019
134 (Supplement_1): 3559
|
|
6776
Orkin SH, Bauer DE.
Emerging Genetic Therapy for Sickle Cell Disease
Annu Rev Med
2019
70:257-271
PubMed ID: 30355263
|
|
6789
Yu X, Azzo A, Bilinovich SM, Li X, Dozmorov M, Kurita R, Nakamura Y, Williams DC Jr, Ginder GD.
Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells.
Haematologica
2019
104(12):2361-2371
PubMed ID: 31004025
|
|
6793
Kurita R, Funato K, Abe T, Watanabe Y, Shiba M, Tadokoro K, Nakamura Y, Nagai T, Satake M
Establishment and characterization of immortalized erythroid progenitor cell lines derived from a common cell source.
Exp Hematol
2019
69:11-16
PubMed ID: 30326248
|
|
6799
Sher F, Hossain M, Seruggia D, Schoonenberg VAC, Yao Q, Cifani P, Dassama LMK, Cole MA, Ren C, Vinjamur DS, Macias-Trevino C, Luk K, McGuckin C, Schupp PG, Canver MC, Kurita R, Nakamura Y, Fujiwara Y, Wolfe SA, Pinello L, Maeda T, Kentsis A, Orkin SH, Bauer DE
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis.
Nat Genet
2019
51(7):1149-1159
PubMed ID: 31253978
|
|
6809
Ron Baik, Stacia K. Wyman, Shaheen Kabir, Jacob E. Corn1
Genome editing to model and reverse a prevalent mutation associated with myeloproliferative
bioRxiv
2019
|
|
6811
Damien J. Downes, Ron Schwessinger, Stephanie J. Hill, Lea Nussbaum, Caroline Scott, Matthew E. Gosden, Priscila P. Hirschfeld, Jelena M. Telenius, Chris Q. Eijsbouts, Simon J. McGowan, Antony J. Cutler, Jon Kerry, Jessica L. Davies, Calliope A. Dendrou, Jamie R.J. Inshaw, Martin S.C. Larke, A. Marieke Oudelaar, Yavor Bozhilov, Andrew J. King, Richard C. Brown, Maria C. Suciu, James O.J. Davies, Philip Hublitz, Chris Fisher, Ryo Kurita, Yukio Nakamura, Gerton Lunter, Stephen Taylor, Veronica J. Buckle, John A. Todd, Douglas R. Higgs, & Jim R. Hughes.
An integrated platform to systematically identify causal variants and genes for polygenic human traits
bioRxiv
2019
|
|
6816
Papasavva P, Kleanthous M, Lederer CW.
Rare Opportunities: CRISPR/Cas-Based Therapy Development for Rare Genetic Diseases.
Mol Diagn Ther.
2019
23(2):201-222
PubMed ID: 30945166
|
|
6821
Finotti A, Fabbri E, Lampronti I, Gasparello J, Borgatti M, Gambari R.
MicroRNAs and Long Non-coding RNAs in Genetic Diseases.
Mol Diagn Ther
2019
23(2):155-171
PubMed ID: 30610665
|
|
8953
Gabriella E Martyn, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Kate G R Quinlan, Merlin Crossley
A Natural Regulatory Mutation in the Proximal Promoter Elevates Fetal globin Expression by Creating a De Novo GATA1 Site
Blood
2019
133 (8), 852-856
PubMed ID: 30617196
|
|
9888
Dipti Gupta, Samuel Lessard, PhD, Nancy Moore, Jicheng Duan, PhD, Yukio Nakamura, MD PhD, Feng-Chun Yang, MD PhD, Alexandra Hicks, PhD, David R. Light, PhD, Sriram Krishnamoorthy, PhD
Genetic Activation of NRF2 By KEAP1 Inhibition Induces Fetal Hemoglobin Expression and Triggers Anti-Oxidant Stress Response in Erythroid Cells
Blood
2019
134 (Supplement_1): 210
|
|
4404
Moir-Meyer G, Cheong PL, Olijnik AA, Brown J, Knight S, King A, Kurita R, Nakamura Y, Gibbons RJ, Higgs DR, Buckle VJ, Babbs C.
Robust CRISPR/Cas9 Genome Editing of the HUDEP-2 Erythroid Precursor Line Using Plasmids and Single-Stranded Oligonucleotide Donors
Methods Protoc
2018
1(3)
PubMed ID: 31164570
|
|
4247
Liu J, Li Y, Tong J, Gao J, Guo Q, Zhang L, Wang B, Zhao H, Wang H, Jiang E, Kurita R, Nakamura Y, Tanabe O, Engel JD, Bresnick EH, Zhou J, Shi L.
Long non-coding RNA-dependent mechanism to regulate heme biosynthesis and erythrocyte development.
Nat Commun
2018
PubMed ID: 30349036
|
|
4974
Morrison TA, Wilcox I, Luo HY, Farrell JJ, Kurita R, Nakamura Y, Murphy GJ, Cui S, Steinberg MH, Chui DHK.
A long noncoding RNA from the HBS1L-MYB intergenic region on chr6q23 regulates human fetal hemoglobin expression.
Blood Cells Mol Dis
2018
69:1-9
PubMed ID: 29227829
|
|
6728
Ghosh A, Garee G, Sweeny EA, Nakamura Y, Stuehr DJ.
Hsp90 chaperones hemoglobin maturation in erythroid and nonerythroid cells.
Proc Natl Acad Sci U S A
2018
115(6):E1117-E1126
PubMed ID: 29358373
|
|
6761
Lee E, Sivalingam J, Lim ZR, Chia G, Shi LG, Roberts M, Loh YH, Reuveny S, Oh SK.
Review: In vitro generation of red blood cells for transfusion medicine: Progress, prospects and challenges.
Biotechnol Adv
2018
36(8):2118-2128
PubMed ID: 30273713
|
|
6773
Martyn GE, Wienert B, Yang L, Shah M, Norton LJ, Burdach J, Kurita R, Nakamura Y, Pearson RCM, Funnell APW, Quinlan KGR, Crossley M
Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding.
Nat Genet
2018
50(4):498-503
PubMed ID: 29610478
|
|
6784
Yu L, Jearawiriyapaisarn N, Lee MP, Hosoya T, Wu Q, Myers G, Lim KC, Kurita R, Nakamura Y, Vojtek AB, Rual JF, Engel JD.
BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.
Genes Dev
2018
32(23-24):1537-1549
PubMed ID: 30463901
|
|
6785
Sun S, Peng Y, Liu J.
Research advances in erythrocyte regeneration sources and methods in vitro.
Cell Regen (Lond)
2018
7(2):45-49
PubMed ID: 30671230
|
|
6786
Loucari CC, Patsali P, van Dijk TB, Stephanou C, Papasavva P, Zanti M, Kurita R, Nakamura Y, Christou S, Sitarou M, Philipsen S, Lederer CW, Kleanthous M.
Rapid and Sensitive Assessment of Globin Chains for Gene and Cell Therapy of Hemoglobinopathies.
Hum Gene Ther Methods
2018
29(1):60-74
PubMed ID: 29325430
|
|
6787
Vinjamur DS, Bauer DE, Orkin SH
Recent progress in understanding and manipulating haemoglobin switching for the haemoglobinopathies.
Br J Haematol
2018
180(5):630-643
PubMed ID: 29193029
|
|
6788
Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, Orkin SH.
Direct Promoter Repression by BCL11A Controls the Fetal to Adult Hemoglobin Switch.
Cell
2018
173(2):430-442.e17
PubMed ID: 29606353
|
|
6790
Khalil S, Delehanty L, Grado S, Holy M, White Z 3rd, Freeman K, Kurita R, Nakamura Y, Bullock G, Goldfarb A.
Iron modulation of erythropoiesis is associated with Scribble-mediated control of the erythropoietin receptor.
J Exp Med
2018
215(2):661-679
PubMed ID: 29282252
|
|
6798
Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, View ORCID ProfileJean-François Rual, View ORCID ProfileJames Douglas Engel
BAP1 deubiquitinase is a potent repressor of fetal hemoglobin biosynthesis
bioRxiv
2018
|
|
6813
Wienert B, Martyn GE, Funnell APW, Quinlan KGR, Crossley M.
Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.
Trends Genet
2018
34(12):927-940
PubMed ID: 30287096
|
|
6817
Lau CH, Suh Y.
CRISPR-based strategies for studying regulatory elements and chromatin structure in mammalian gene control.
Mamm Genome
2018
29(3-4):205-228
PubMed ID: 29196861
|
|
6819
Paikari A, Sheehan VA.
Fetal haemoglobin induction in sickle cell disease.
Br J Haematol
2018
180(2):189-200
PubMed ID: 29143315
|
|
8954
Tyler A Couch, BS , Zachary C. Murphy, PhD , Michael Getman, MS , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Laurie A. Steiner, MD
Human Erythroblasts with c-Kit Activating Mutations Have Reduced Cell Culture Costs and Remain Capable of Terminal Maturation and Enucleation
Blood
2018
132 (Supplement 1): 2315
|
|
8956
Laura Breda, PhD , Valentina Ghiaccio, PhD , Hanyia Zaidi , Silvia Pires Lourenco, MSc , Carla Casu , Kim Smith-Whitley, MD , Janet L. Kwiatkowski, MD , Vanessa Carrion, RN, CPN , Virginia Guzikowski, RN, MSN, CRNP , Ryo Kurita, PhD , Yukio Nakamura, MD PhD ,
Improved Lentiviral Vectors for the Cure of Hemoglobinopathies
Blood
2018
132 (Supplement 1): 3477
|
|
8958
Yuxuan Wu, PhD , Mitchel A. Cole, BS , Abdou Mousas , Jing Zeng, MD , Qiuming Yao, PhD , Divya Vinjamur, PhD , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Luca Pinello, PhD , Guillame Lettre, PhD , Daniel E. Bauer, MD PhD
Comprehensive Integrated Genomic Perturbations Reveal Molecular Mechanisms of Red Blood Cell Trait Associations
Blood
2018
132 (Supplement 1): 532
|
|
8968
Tyler A Couch, BS , Zachary C. Murphy, PhD , Jacquelyn Lillis, MS , Michael Getman, MS , Paul D. Kingsley, PhD , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Laurie A. Steiner, MD
High-Level Setd8 Expression Is Important for Establishment of Normal Patterns of Erythroid Gene Expression and Is Essential for Stress Erythropoiesis
Blood
2018
132 (Supplement 1): 499
|
|
4973
Wienert B, Martyn GE, Kurita R, Nakamura Y, Quinlan KGR1, Crossley M.
KLF1 drives the expression of fetal hemoglobin in British HPFH.
Blood
2017
130(6):803-807
PubMed ID: 28659276
|
|
6750
Trakarnsanga K, Griffiths RE, Wilson MC, Blair A, Satchwell TJ, Meinders M, Cogan N, Kupzig S, Kurita R, Nakamura Y, Toye AM, Anstee DJ, Frayne J.
An immortalized adult human erythroid line facilitates sustainable and scalable generation of functional red cells.
Nat Commun
2017
8:14750
PubMed ID: 28290447
|
|
6765
Yankai Zhang, PhD , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Vivien Sheehan, MD PhD
Screening Fetal Hemoglobin Inducing Compounds in Human Umbilical Cord Blood-Derived Erythroid Progenitor Cells
Blood
2017
130 (Supplement 1): 2222
|
|
6777
Lessard S, Gatof ES, Beaudoin M, Schupp PG, Sher F, Ali A, Prehar S, Kurita R, Nakamura Y, Baena E, Ledoux J, Oceandy D, Bauer DE, Lettre G.
An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.
J Clin Invest
2017
127(8):3065-3074
PubMed ID: 28714864
|
|
6778
Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galactéros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, A Cole M, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH.
Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci.
Nat Genet
2017
49(4):625-634
PubMed ID: 28218758
|
|
6791
Hodonsky CJ, Jain D, Schick UM, Morrison JV, Brown L, McHugh CP, Schurmann C, Chen DD, Liu YM, Auer PL, Laurie CA, Taylor KD, Browning BL, Li Y, Papanicolaou G1, Rotter JI, Kurita R, Nakamura Y, Browning SR, Loos RJF, North KE, Laurie CC, Thornton TA, Pankratz N, Bauer DE, Sofer T, Reiner AP.
Genome-wide association study of red blood cell traits in Hispanics/Latinos: The Hispanic Community Health Study/Study of Latinos.
PLoS Genet
2017
13(4):e1006760
PubMed ID: 28453575
|
|
6803
Habara AH, Shaikho EM, Steinberg MH.
Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents.
Am J Hematol
2017
92(11):1233-1242
PubMed ID: 28736939
|
|
6818
Ipe J, Swart M, Burgess KS, Skaar TC.
High-Throughput Assays to Assess the Functional Impact of Genetic Variants: A Road Towards Genomic-Driven Medicine.
Clin Transl Sci
2017
10(2):67-77
PubMed ID: 28213901
|
|
8824
Yan Dai, PhD , Tyngwei Chen , Heba Ijaz , Elizabeth Cho , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Martin H. Steinberg, MD
SIRT1 Increases the Expression of Fetal Hemoglobin Genes in Human Adult and Cord Blood Erythroblasts
Blood
2017
130 (Supplement 1): 287
|
|
8955
Silvia Pires Lourenco, MSc , Amaliris Gonzalez, PhD , Tobias Raabe, PhD , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Laura Breda, PhD , Stefano Rivella, PhD
Generation of New Cell Models to Screen Improved Vectors for Functional Hemoglobin Expression
Blood
2017
130 (Supplement 1): 5563
|
|
8962
Laura J Norton, Alister P W Funnell, Jon Burdach, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Sjaak Philipsen, Richard C M Pearson, Kate G R Quinlan, Merlin Crossley
KLF1 Directly Activates Expression of the Novel Fetal Globin Repressor ZBTB7A/LRF in Erythroid Cells
Blood Adv
2017
1 (11), 685-692
PubMed ID: 29296711
|
|
8966
Shadi Khalil, Maja Holy, Stephen Grado, Robert Fleming, Ryo Kurita, Yukio Nakamura, Adam Goldfarb
A Specialized Pathway for Erythroid Iron Delivery Through Lysosomal Trafficking of Transferrin Receptor 2
Blood Adv
2017
1 (15), 1181-1194
PubMed ID: 29296759
|
|
8967
Brian M Dulmovits, MS , Julien Papoin, MS , Jian Hua Li, MS , Ryo Kurita, PhD , Yukio Nakamura, MD PhD , Yousef Al-Abed, MD , Luanne L. Peters, PhD , Betty Diamond, MD , Anupama Narla, MD , Jeffrey M Lipton, MDPhD , Mohandas Narla, DSc , Kevin Tracey, MD , Lionel Blanc, PhD
High Mobility Group Box 1 Protein (HMGB1) Mediates Anemia of Inflammation through Lineage Skewing and Direct Inhibition of EPO Signaling
Blood
2017
130 (Supplement 1): 2196
|
|
6762
Masuda T, Wang X, Maeda M, Canver MC, Sher F, Funnell AP, Fisher C, Suciu M, Martyn GE, Norton LJ, Zhu C, Kurita R, Nakamura Y, Xu J, Higgs DR, Crossley M, Bauer DE, Orkin SH, Kharchenko PV, Maeda T.
Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
Science
2016
351(6270):285-9
PubMed ID: 26816381
|
|
6764
Traxler EA, Yao Y, Wang YD, Woodard KJ, Kurita R, Nakamura Y, Hughes JR, Hardison RC, Blobel GA, Li C, Weiss MJ.
A genome-editing strategy to treat β-hemoglobinopathies that recapitulates a mutation associated with a benign genetic condition.
Nat Med
2016
22(9):987-90
PubMed ID: 27525524
|
|
6774
Orkin SH.
Recent advances in globin research using genome-wide association studies and gene editing.
Ann N Y Acad Sci
2016
368(1):5-10
PubMed ID: 26866328
|
|
6795
Smith EC, Orkin SH.
Hemoglobin genetics: recent contributions of GWAS and gene editing.
Hum Mol Genet
2016
25(R2):R99-R105
PubMed ID: 27340226
|
|
6804
Prakash V, Moore M, Yáñez-Muñoz RJ.
Current Progress in Therapeutic Gene Editing for Monogenic Diseases.
Mol Ther
2016
24(3):465-74
PubMed ID: 26765770
|
|
6820
Cottle RN, Lee CM, Bao G.
Treating hemoglobinopathies using gene-correction approaches: promises and challenges.
Hum Genet
2016
135(9):993-1010
PubMed ID: 27314256
|
|
8963
Sriram Krishnamoorthy , Dipti Gupta , William E. Hobbs, MD PhD , Christine Loh, PhD , David R. Light , Robert Peters, PhD , Sarah Sturtevant , Betty Pace, MD , Yukio Nakamura , Brian Lucas , Benjamin F. Vieira
Nrf2 activation and fetal hemoglobin induction in sickle cell disease
Blood
2016
128 (22): 4840
|
|
6756
Kim YH, Kim HO, Baek EJ, Kurita R, Cha HJ, Nakamura Y, Kim H.
Rh D blood group conversion using transcription activator-like effector nucleases.
Nat Commun
2015
6:7451
PubMed ID: 26078220
|
|
6775
Canver MC, Smith EC, Sher F, Pinello L, Sanjana NE, Shalem O, Chen DD, Schupp PG, Vinjamur DS, Garcia SP, Luc S, Kurita R, Nakamura Y, Fujiwara Y, Maeda T, Yuan GC, Zhang F, Orkin SH, Bauer DE.
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis.
Nature
2015
527(7577):192-7
PubMed ID: 26375006
|
|
6742
Kurita R, Suda N, Sudo K, Miharada K, Hiroyama T, Miyoshi H, Tani K, Nakamura Y.
Establishment of immortalized human erythroid progenitor cell lines able to produce enucleated red blood cells.
PLoS One
2013
8(3):e59890
PubMed ID: 23533656
|
|
9631
Richard A. Morgan et al
Creating New β-globin-Expressing Lentiviral Vectors by High-Resolution Mapping of Locus Control Region Enhancer Sequences
Molecular Therapy: Methods & Clinical Development
2010
|
|
8965
Chiara Antoniani, Vasco Meneghini, Annalisa Lattanzi, Tristan Felix, Oriana Romano, Elisa Magrin, Leslie Weber, Giulia Pavani, Sara El Hoss, Ryo Kurita, Yukio Nakamura, Thomas J Cradick, Ante S Lundberg, Matthew Porteus, Mario Amendola, Wassim El Nemer, Marina Cavazzana, Fulvio Mavilio, Annarita Miccio
Induction of Fetal Hemoglobin Synthesis by CRISPR/Cas9-mediated Editing of the Human β-Globin Locus
Blood
02018
131 (17), 1960-1973
PubMed ID: 29519807
|
| User's Publication |
|
20716
Qin K, Huang P, Feng R, Keller CA, Peslak SA, Khandros E, Saari MS, Lan X, Mayuranathan T, Doerfler PA, Abdulmalik O, Giardine B, Chou ST, Shi J, Hardison RC, Weiss MJ, Blobel GA.
Dual function NFI factors control fetal hemoglobin silencing in adult erythroid cells.
Nat Genet
2022
PubMed ID: 35618846
|
|
20126
Qi Q, Cheng L, Tang X, He Y, Li Y, Yee T, Shrestha D, Feng R, Xu P, Zhou X, Pruett-Miller S, Hardison RC, Weiss MJ, Cheng Y.
Dynamic CTCF binding directly mediates interactions among cis-regulatory elements essential for hematopoiesis.
Blood
2021
137(10):1327-1339
PubMed ID: 33512425
|
|
20255
Doerfler PA, Feng R, Li Y, Palmer LE, Porter SN, Bell HW, Crossley M, Pruett-Miller SM, Cheng Y, Weiss MJ.
Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.
Nat Genet
2021
53(8):1177-1186
PubMed ID: 34341563
|
|
20388
Downes DJ, Cross AR, Hua P, Roberts N, Schwessinger R, Cutler AJ, Munis AM, Brown J, Mielczarek O, de Andrea CE, Melero I, COvid-19 Multi-omics Blood ATlas (COMBAT) Consortium, Gill DR, Hyde SC, Knight JC, Todd JA, Sansom SN, Issa F, Davies JOJ, Hughes JR.
Identification of LZTFL1 as a candidate effector gene at a COVID-19 risk locus.
Nat Genet
2021
53(11):1606-1615
PubMed ID: 34737427
|
|
20449
Georgolopoulos G, Psatha N, Iwata M, Nishida A, Som T, Yiangou M, Stamatoyannopoulos JA, Vierstra J.
Discrete regulatory modules instruct hematopoietic lineage commitment and differentiation.
Nat Commun
2021
12(1):6790
PubMed ID: 34815405
|
|
16052
Xu P, Scott DC, Xu B, Yao Y, Feng R, Cheng L, Mayberry K, Wang YD, Bi W, Palmer LE, King MT, Wang H, Li Y, Fan Y, Alpi AF, Li C, Peng J, Papizan J, Pruett-Miller SM, Spallek R, Bassermann F, Cheng Y, Schulman BA, Weiss MJ.
FBXO11-mediated proteolysis of BAHD1 relieves PRC2-dependent transcriptional repression in erythropoiesis
Blood
2021
137(2):155-167.
PubMed ID: 33156908
|
|
16055
Liu N, Xu S, Yao Q, Zhu Q, Kai Y, Hsu JY, Sakon P, Pinello L, Yuan GC, Bauer DE, Orkin SH.
Transcription factor competition at the γ-globin promoters controls hemoglobin switching
Nat Genet
2021
53(4):511-520
PubMed ID: 33649594
|
|
16059
Cheng L, Li Y, Qi Q, Xu P, Feng R, Palmer L, Chen J, Wu R, Yee T, Zhang J, Yao Y, Sharma A, Hardison RC, Weiss MJ, Cheng Y.
Single-nucleotide-level mapping of DNA regulatory elements that control fetal hemoglobin expression
Nat Genet
2021
53(6):869-880
PubMed ID: 33958780
|
|
16060
Vinjamur DS, Yao Q, Cole MA, McGuckin C, Ren C, Zeng J, Hossain M, Luk K, Wolfe SA, Pinello L, Bauer DE.
ZNF410 represses fetal globin by singular control of CHD4
Nat Genet
2021
53(5):719-728
PubMed ID: 33859416
|
|
16062
Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR.
MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease
Blood Adv . 2021
2021
1388-1402
PubMed ID: 33661300
|
|
16065
Baik R, Wyman SK, Kabir S, Corn JE.
Genome editing to model and reverse a prevalent mutation associated with myeloproliferative neoplasms
PLoS One
2021
16(3):e0247858
PubMed ID: 33661998
|
|
6780
Makino T, Haruyama M, Katayama K, Terashima H, Tsunemi T, Miyazaki K, Terakawa M, Yamashiro K, Yoshioka R, Maeda H.
Phenotypic-screening generates active novel fetal globin-inducers that downregulate Bcl11a in a monkey model.
Biochem Pharmacol
2020
171:113717
PubMed ID: 31751536
|
|
14505
Demirci S, Gudmundsdottir B, Li Q, Haro-Mora JJ, Nassehi T, Drysdale C, Yapundich M, Gamer J, Seifuddin F, Tisdale JF, Uchida N.
βT87Q-Globin Gene Therapy Reduces Sickle Hemoglobin Production, Allowing for Ex Vivo Anti-sickling Activity in Human Erythroid Cells
Mol Ther Methods Clin Dev
2020
17:912-921.
PubMed ID: 32405513
|
|
6745
Hyle J, Zhang Y, Wright S, Xu B, Shao Y, Easton J, Tian L, Feng R, Xu P, Li C.
Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.
Nucleic Acids Res
2019
47(13):6699-6713
PubMed ID: 31127282
|
|
6766
Mudit Chaand, PhD , Chris Fiore, PhD , Brian T Johnston, MS , Diane H Moon, PhD , John P Carulli, PhD , Jeffrey R Shearstone, PhD
Chromatin Accessibility Mapping of Primary Erythroid Cell Populations Leads to Identification and Validation of Nuclear Factor I X (NFIX) As a Novel Fetal Hemoglobin (HbF) Repressor
Blood
2019
134 (Supplement_1): 812
|
|
6767
Laura Breda, PhD , Valentina Ghiaccio, PhD , Silvia Pires Lourenco, MSc , Danuta Jadwiga Jarocha, PhD , Yasuhiro Ikawa, MD PhD , Naoto Tanaka, PhD , Virginia Guzikowski , Carla Casu, PhD , Kim Smith-Whitley, MD , Janet L. Kwiatkowski, MD MSCE , Stefano Rivella, PhD
Preclinical Evaluation of ALS20, a New and Improved Lentiviral Vector for Beta-Globinopathies
Blood
2019
134 (Supplement_1): 2242
|
|
6769
Craig M Forester, MD PhD , Gun Woo-Byeon , Juan Oses-Prieto, PhD , Al Burlingame, PhD , Maria Barna, PhD , Davide M Ruggero, PhD
Regulation of eIF4E Guides a Unique Translational Program to Steer Erythroid Maturation
Blood
2019
134 (Supplement_1): 156
|
|
6772
Kang J, Kang Y, Kim YW, You J, Kang J, Kim A.
LRF acts as an activator and repressor of the human β-like globin gene transcription in a developmental stage dependent manner.
Biochem Cell Biol
2019
97(4):380-386
PubMed ID: 30427207
|
|
6779
Sukanya Chumchuen, MSc, BSc , Tanapat Pornsukjantra, B.Sc. , Pinyaphat Khamphikham, PhD , Usanarat Anurathapan, MD , Orapan Sripichai, PhD
Downregulation of Transcription Factor LRF/ZBTB7A Increases Fetal Hemoglobin Expression in β-Thalassemia/Hemoglobin E Erythroid Cells
Blood
2019
134 (Supplement_1): 3549
|
|
6783
Pamela Himadewi, BSc , Xiaotian Zhang, PhDBS , Haley Gore, MS , Xue Qing David Wang, PhD
Chromosomal Loop Editing Reveals New Epigenomic Landscape in the β-Globin Locus with Implications for Hemoglobinopathy Therapies
Blood
2019
134 (Supplement_1): 813
|
|
6792
Zhou Z, Giles KE, Felsenfeld G.
DNA·RNA triple helix formation can function as a cis-acting regulatory mechanism at the human β-globin locus.
Proc Natl Acad Sci U S A
2019
116(13):6130-6139
PubMed ID: 30867287
|
|
6794
Li C, Mishra AS, Gil S, Wang M, Georgakopoulou A, Papayannopoulou T, Hawkins RD, Lieber A.
Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors.
Mol Ther
2019
27(12):2195-2212
PubMed ID: 31494053
|
|
6797
Wang H, Liu Z, Li C, Gil S, Papayannopoulou T, Doering CB, Lieber A
High-level protein production in erythroid cells derived from in vivo transduced hematopoietic stem cells.
Blood Adv
2019
3(19):2883-2894
PubMed ID: 31585952
|
|
6801
Ludwig LS, Lareau CA, Bao EL, Nandakumar SK, Muus C, Ulirsch JC, Chowdhary K, Buenrostro JD, Mohandas N, An X, Aryee MJ, Regev A, Sankaran VG.
Transcriptional States and Chromatin Accessibility Underlying Human Erythropoiesis.
Cell Rep
2019
27(11):3228-3240.e7
PubMed ID: 31189107
|
|
6810
Métais JY, Doerfler PA, Mayuranathan T, Bauer DE, Fowler SC, Hsieh MM, Katta V, Keriwala S, Lazzarotto CR, Luk K, Neel MD, Perry SS, Peters ST, Porter SN, Ryu BY, Sharma A, Shea D, Tisdale JF, Uchida N, Wolfe SA, Woodard KJ, Wu Y, Yao Y, Zeng J, Pruett-Miller S, Tsai SQ, Weiss MJ.
Genome editing of HBG1 and HBG2 to induce fetal hemoglobin.
Blood Adv
2019
3(21):3379-3392
PubMed ID: 31698466
|
|
6815
Damena D, Denis A, Golassa L, Chimusa ER.
Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.
BMC Med Genomics
2019
12(1):120
PubMed ID: 31409341
|
|
4246
Schoonenberg VAC, Cole MA, Yao Q, Macias-Treviño C, Sher F, Schupp PG, Canver MC, Maeda T, Pinello L, Bauer DE.
CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis.
Genome Biol.
2018
PubMed ID: 30340514
|
|
4518
Vinjamur DS, Bauer DE
Growing and Genetically Manipulating Human Umbilical Cord Blood-Derived Erythroid Progenitor (HUDEP) Cell Lines.
Erythropoiesis
2018
275-284
PubMed ID: 29076097
|
|
6782
Li C, Psatha N, Gil S, Wang H, Papayannopoulou T, Lieber A.
HDAd5/35++ Adenovirus Vector Expressing Anti-CRISPR Peptides Decreases CRISPR/Cas9 Toxicity in Human Hematopoietic Stem Cells.
Mol Ther Methods Clin Dev
2018
9:390-401
PubMed ID: 30038942
|
|
6805
Nussbaum L, Telenius JM, Hill S, Hirschfeld PP, Suciu MC, WIGWAM Consortium, Downes DJ, Hughes JR.
High-Throughput Genotyping of CRISPR/Cas Edited Cells in 96-Well Plates.
Methods Protoc
2018
1(3):29
PubMed ID: 31164571
|
|
6806
Hsu JY, Fulco CP, Cole MA, Canver MC, Pellin D, Sher F, Farouni R, Clement K, Guo JA, Biasco L, Orkin SH, Engreitz JM, Lander ES, Joung JK, Bauer DE, Pinello L.
CRISPR-SURF: discovering regulatory elements by deconvolution of CRISPR tiling screen data.
Nat Methods
2018
15(12):992-993
PubMed ID: 30504875
|
|
6807
Shukla A, Huangfu D.
Decoding the noncoding genome via large-scale CRISPR screens.
Curr Opin Genet Dev
2018
52:70-76
PubMed ID: 29913329
|
|
6812
Leung A, Zulick E, Skvir N, Vanuytsel K, Morrison TA, Naing ZH, Wang Z, Dai Y, Chui DHK, Steinberg MH, Sherr DH, Murphy GJ.
Notch and Aryl Hydrocarbon Receptor Signaling Impact Definitive Hematopoiesis from Human Pluripotent Stem Cells.
Stem Cells
2018
36(7):1004-1019
PubMed ID: 29569827
|
|
6822
Canver MC, Haeussler M, Bauer DE, Orkin SH, Sanjana NE, Shalem O, Yuan GC, Zhang F, Concordet JP, Pinello L
Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experiments.
Nat Protoc
2018
13(5):946-986
PubMed ID: 29651054
|
|
6781
Maroofi N, Azarkeivan A, Banihashemi S, Mohammadparast S, Aghajanirefah A, Banan M.
An enhancer haplotype may influence BCL11A expression levels and the response to hydroxyurea in β-thalassemia patients.
Pharmacogenomics
2017
18(10):995-967
PubMed ID: 28639471
|
|
6800
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F.
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Nat Protoc
2017
12(4):828-863
PubMed ID: 28333914
|
|
6802
Wright JB, Sanjana NE.
CRISPR Screens to Discover Functional Noncoding Elements.
Trends Genet
2016
32(9):526-529
PubMed ID: 27423542
|
Back
Top
CELL BANK Website