細胞番号 : 細胞名 RCB4486 : AFS98  update : 2024/08/14
細胞特性(Comment:英)			Hybridoma cell line producing anti-mouse c-fms (CD115) antibody.
細胞特性(日)			ハイブリドーマ細胞株。抗マウスc-fms (CD115)抗体産生。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)			1) The BIOLOGICAL RESOURCE shall be used for teaching or not-for-profit research purpose only. (Commercial use is prohibited by the DEPOSITOR.) 2) In publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Oncogene 1995;11:2469-2476) is necessary.
使用条件(日)			1) 教育･研究目的のみ利用可。商業目的の利用不可。 2) 利用者は、研究成果の公表にあたって寄託者の指定する文献 (Oncogene 1995;11:2469-2476) を引用すること。
備考(英)
備考(日)
提供申込書類(英)			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日)			依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf
			提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください（詳細）。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料			手数料とお支払いについてはこちらをご覧ください。
細胞基本情報		寄託者	Nishikawa, Shin-ichi
		樹立者	Nishikawa, Satomi
		寄託日	2012
		別名	anti mouse c-fms
		動物種	_mouse x rat < Hybrid
		採取組織	hybridoma
		細胞分類	hybrid cells
		細胞寿命	infinite
		細胞形態	lymphocyte-like
		Cellosaurus(Expasy)	CVCL_KA99
ハイブリドーマ関連		親細胞１の細胞名	spleen cells
		親細胞１の動物名及び系統名	rat, Wistar
		親細胞２の細胞名	X63-Ag8/653
		親細胞２の動物名及び系統名	mouse
		細胞融合・選択法	PEG #4000, HAT selection
		単クローン性抗体名	AFS98
		サブクラス	rat IgG2a
		免疫に用いた材料	Murine c-fms fused to hIgG FC
		抗体で検出される抗原の名称	c-fms (CD115)
		分子量	150kDa
		抗体で検出される抗原の性状	transmembrane tyrosin-kinase receptor
		陽性細胞・組織	monoocyte, osteoclast, macrophage, peritorial exudate cells, plasmacytoid and conventional dendritic cells
細胞培養・検査情報			寄託時情報	ロット情報
	培地・試薬情報		培地・試薬一覧はこちらをご覧ください。
		培養形態		Suspension cells
		培養方法		General Guidelines for Culturing Suspension Cells, 浮遊細胞の培養に関する一般的な注意(Japanese)
		培地		RPMI1640 + 10% FBS + 50μM 2-Mercaptoethanol
		抗生物質		Free
		継代方法		dilution
		継代密度		1 : 10 split
		継代・培地交換頻度		Subculture : 2 times/week
		培養最適温度		37 ℃
		二酸化炭素濃度		5 %
		凍結培地		90% FBS + 10% DMSO
		凍結方法		Slow freezing
		マイコプラズマ/アコレプラズマ		(-)
		産生抗体のサブクラス		rat IgG2a
画像情報			寄託時情報	ロット情報
文献情報		Reference(英)	21件
		Reference(日)	0件
		利用者成果(英)	2件
		利用者成果(日)	0件

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Reference(英)

8915  Alexandra M Ochsenbein, Sinem Karaman, Steven T Proulx, Rhea Goldmann, Jyothi Chittazhathu, Athanasia Dasargyri, Chloé Chong, Jean-Christophe Leroux, E Richard Stanley, Michael Detmar  Regulation of Lymphangiogenesis in the Diaphragm by Macrophages and VEGFR-3 Signaling  Angiogenesis  2016  19 (4), 513-24  PubMed ID: 27464987   DOI: 10.1007/s10456-016-9523-8

8936  Cynthia Louis, Andrew D Cook, Derek Lacey, Andrew J Fleetwood, Ross Vlahos, Gary P Anderson, John A Hamilton  Specific Contributions of CSF-1 and GM-CSF to the Dynamics of the Mononuclear Phagocyte System  J Immunol  2015  195 (1), 134-44  PubMed ID: 26019271   DOI: 10.4049/jimmunol.1500369

8432  Laetitia Fend, Nathalie Accart, Jacqueline Kintz, Sandrine Cochin, Carine Reymann, Fabrice Le Pogam, Jean-Baptiste Marchand, Thierry Menguy, Philippe Slos, Ronald Rooke, Sylvie Fournel, Jean-Yves Bonnefoy, Xavier Préville, Hélène Haegel  Therapeutic Effects of anti-CD115 Monoclonal Antibody in Mouse Cancer Models Through Dual Inhibition of Tumor-Associated Macrophages and Osteoclasts  PLoS One  2013  8 (9), e73310 2013  PubMed ID: 24019914   DOI: 10.1371/journal.pone.0073310

8919  Melanie Greter, Iva Lelios, Pawel Pelczar, Guillaume Hoeffel, Jeremy Price, Marylene Leboeuf, Thomas M Kündig, Karl Frei, Florent Ginhoux, Miriam Merad, Burkhard Becher  Stroma-derived interleukin-34 Controls the Development and Maintenance of Langerhans Cells and the Maintenance of Microglia  Immunity  2012  37 (6), 1050-1060  PubMed ID: 23177320   DOI: 10.1016/j.immuni.2012.11.001

8924  Takahiro Tsuchiya, Norifumi Nakao, Shigeo Yamamoto, Yoshikazu Hirai, Katsushiro Miyamoto, Hiroshi Tsujibo  NK1.1(+) Cells Regulate Neutrophil Migration in Mice With Acinetobacter Baumannii Pneumonia  Microbiol Immunol  2012  56 (2), 107-16  PubMed ID: 22145920   DOI: 10.1111/j.1348-0421.2011.00402.x

8923  Suwen Wei, Sayan Nandi, Violeta Chitu, Yee-Guide Yeung, Wenfeng Yu, Minmei Huang, Lewis T Williams, Haishan Lin, E Richard Stanley  Functional Overlap but Differential Expression of CSF-1 and IL-34 in Their CSF-1 Receptor-Mediated Regulation of Myeloid Cells  J Leukoc Biol  2010  88 (3), 495-505  PubMed ID: 20504948   DOI: 10.1189/jlb.1209822

8927  Dmitry A Ovchinnikov, Claire E E DeBats, David P Sester, Matthew J Sweet, David A Hume  A Conserved Distal Segment of the Mouse CSF-1 Receptor Promoter Is Required for Maximal Expression of a Reporter Gene in Macrophages and Osteoclasts of Transgenic Mice  J Leukoc Biol  2010  87 (5), 815-22  PubMed ID: 20123678   DOI: 10.1189/jlb.0809557

8580  Masashi Segawa, So-ichiro Fukada, Yukiko Yamamoto, Hiroshi Yahagi, Masanori Kanematsu, Masaki Sato, Takahito Ito, Akiyoshi Uezumi, Shin'ichi Hayashi, Yuko Miyagoe-Suzuki, Shin'ichi Takeda, Kazutake Tsujikawa, Hiroshi Yamamoto  Suppression of Macrophage Functions Impairs Skeletal Muscle Regeneration With Severe Fibrosis  Exp Cell Res  2008  314 (17), 3232-44  PubMed ID: 18775697   DOI: 10.1016/j.yexcr.2008.08.008

8925  Wenfeng Yu, Jian Chen, Ying Xiong, Fiona J Pixley, Xu-Ming Dai, Yee-Guide Yeung, E Richard Stanley  CSF-1 Receptor Structure/Function in MacCsf1r-/- Macrophages: Regulation of Proliferation, Differentiation, and Morphology  J Leukoc Biol  2008  84 (3), 852-63  PubMed ID: 18519746   DOI: 10.1189/jlb.0308171

8931  Ivana Boban, Claire Jacquin, Katie Prior, Tatjana Barisic-Dujmovic, Peter Maye, Stephen H Clark, Hector L Aguila  The 3.6 Kb DNA Fragment From the Rat Col1a1 Gene Promoter Drives the Expression of Genes in Both Osteoblast and Osteoclast Lineage Cells  Bone  2006  39 (6), 1302-12  PubMed ID: 16938497   DOI: 10.1016/j.bone.2006.06.025

8932  Claire Jacquin, Diane E Gran, Sun Kyeong Lee, Joseph A Lorenzo, Hector L Aguila  Identification of Multiple Osteoclast Precursor Populations in Murine Bone Marrow  J Bone Miner Res  2006  21 (1), 67-77  PubMed ID: 16355275   DOI: 10.1359/JBMR.051007

8585  Motokazu Tsuneto, Hidetoshi Yamazaki, Miya Yoshino, Takayuki Yamada, Shin-Ichi Hayashi  Ascorbic Acid Promotes Osteoclastogenesis From Embryonic Stem Cells  Biochem Biophys Res Commun  2005  335 (4), 1239-46  PubMed ID: 16112648   DOI: 10.1016/j.bbrc.2005.08.016

8934  Kiyoshi Kanazawa, Akira Kudo  TRAF2 Is Essential for TNF-alpha-induced Osteoclastogenesis  J Bone Miner Res  2005  20 (5), 840-7  PubMed ID: 15824857   DOI: 10.1359/JBMR.041225

8937  Tatjana Nikolic, Gerben Bouma, Hemmo A Drexhage, Pieter J M Leenen  Diabetes-prone NOD Mice Show an Expanded Subpopulation of Mature Circulating Monocytes, Which Preferentially Develop Into Macrophage-Like Cells in Vitro  J Leukoc Biol  2005  78 (1), 70-9  PubMed ID: 15788439   DOI: 10.1189/jlb.1104662

8939  Michael B Jordan, David Hildeman, John Kappler, Philippa Marrack  An Animal Model of Hemophagocytic Lymphohistiocytosis (HLH): CD8+ T Cells and Interferon Gamma Are Essential for the Disorder  Blood  2004  104 (3), 735-43  PubMed ID: 15069016   DOI: 10.1182/blood-2003-10-3413

8910  Peter Neumeister, Fiona J Pixley, Ying Xiong, Huafeng Xie, Kongming Wu, Anthony Ashton, Michael Cammer, Amanda Chan, Marc Symons, E Richard Stanley, Richard G Pestell  Cyclin D1 Governs Adhesion and Motility of Macrophages  Mol Biol Cell  2003  14 (5), 2005-15  PubMed ID: 12802071   DOI: 10.1091/mbc.02-07-0102

8926  Y H Yang, J A Hamilton  Dependence of interleukin-1-induced Arthritis on Granulocyte-Macrophage Colony-Stimulating Factor  Arthritis Rheum  2001  44 (1), 111-9  PubMed ID: 11212148   DOI: 10.1002/1529-0131(200101)44:1<111::AID-ANR15>3.0.CO;2-1

8930  K Kaji, R Katogi, Y Azuma, A Naito, J I Inoue, A Kudo  Tumor Necrosis Factor Alpha-Induced Osteoclastogenesis Requires Tumor Necrosis Factor Receptor-Associated Factor 6  J Bone Miner Res  2001  16 (9), 1593-9  PubMed ID: 11547829   DOI: 10.1359/jbmr.2001.16.9.1593

8908  T Yamane, T Kunisada, H Yamazaki, T Nakano, S H Orkin, S I Hayashi  Sequential Requirements for SCL/tal-1, GATA-2, Macrophage Colony-Stimulating Factor, and Osteoclast Differentiation Factor/Osteoprotegerin Ligand in Osteoclast Development  Exp Hematol  2000  28 (7), 833-40  PubMed ID: 10907645   DOI: 10.1016/s0301-472x(00)00175-2

8928  J A Hamilton, R Byrne, G Whitty  Particulate Adjuvants Can Induce Macrophage Survival, DNA Synthesis, and a Synergistic Proliferative Response to GM-CSF and CSF-1  J Leukoc Biol  2000  67 (2), 226-32  PubMed ID: 10670584

5512  Sudo T, Nishikawa S, Ogawa M, Kataoka H, Ohno N, Izawa A, Hayashi S, Nishikawa S.  Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M.  Oncogene  1995  11(12):2469-76  PubMed ID: 8545103

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Reference(日)

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利用者成果(英)

21102  Gottschlich A, Thomas M, Grünmeier R, Lesch S, Rohrbacher L, Igl V, Briukhovetska D, Benmebarek MR, Vick B, Dede S, Müller K, Xu T, Dhoqina D, Märkl F, Robinson S, Sendelhofert A, Schulz H, Umut Ö, Kavaka V, Tsiverioti CA, Carlini E, Nandi S, Strzalkowski T, Lorenzini T, Stock S, Müller PJ, Dörr J, Seifert M, Cadilha BL, Brabenec R, Röder N, Rataj F, Nüesch M, Modemann F, Wellbrock J, Fiedler W, Kellner C, Beltrán E, Herold T, Paquet D, Jeremias I, von Baumgarten L, Endres S, Subklewe M, Marr C, Kobold S.  Single-cell transcriptomic atlas-guided development of CAR-T cells for the treatment of acute myeloid leukemia.  Nat Biotechnol  2023    PubMed ID: 36914885   DOI: 10.1038/s41587-023-01684-0

15105  Lu L, Kuroishi T, Tanaka Y, Furukawa M, Nochi T, Sugawara S.  Differential expression of CD11c defines two types of tissue-resident macrophages with different origins in steady-state salivary glands  Sci Rep  2022  12(1):931  PubMed ID: 35042931   DOI: 10.1038/s41598-022-04941-5

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利用者成果(日)