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細胞番号 : 細胞名
RCB4455 : PC-9  update : 2024/11/22
細胞特性(Comment:英)Human cell line derived from lung adenocarcinoma cells. Differentiated type. Previous name:PC-14(RCB0446)
細胞特性(日)ヒト肺腺癌(分化型)由来細胞株。旧提供:RCB0446 PC-14
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 樹立者 Tsuji, K. & Hayata, Y.
寄託日 1989
別名 RCB0446 PC-14
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
採取組織 lung
細胞分類 cancer
細胞寿命 infinite
細胞形態 other
Cellosaurus(Expasy) CVCL_B260
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
動物種PCR OK
個体識別検査 OK
寄託時情報
ロット情報
D5S818 D13S317 D7S820 D16S539 vWA TH01 Amelogenin TPOX CSF1PO
11 8 10,11 9 17 7 X 11 11
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 0件
Reference(日) 0件
利用者成果(英) 129件
利用者成果(日) 1件

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Reference(英)

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利用者成果(英)
21677  Kim S, Lee Y, Song BR, Sim H, Kang EH, Hwang M, Yu N, Hong S, Park C, Ahn BC, Lim EJ, Hwang KH, Park SY, Choi JH, Lee GK, Han JY.  Drug Response of Patient-Derived Lung Cancer Cells Predicts Clinical Outcomes of Targeted Therapy.  Cancers (Basel)  2024  16(4)  PubMed ID: 38398169   DOI: 10.3390/cancers16040778
21706  Ando S, Tanaka K, Matsumoto M, Oyama Y, Tomabechi Y, Yamagata A, Shirouzu M, Nakagawa R, Okimoto N, Taiji M, Sato K, Ohama T.  The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.  J Biol Chem  2024  107277  PubMed ID: 38588804   DOI: 10.1016/j.jbc.2024.107277
21743  Zha L, Matsu-Ura T, Sluka JP, Murakawa T, Tsuta K.  Morphological basis of the lung adenocarcinoma subtypes.  iScience  2024  27(5):109742  PubMed ID: 38706836   DOI: 10.1016/j.isci.2024.109742
21749  Kohsaka S, Yagishita S, Shirai Y, Matsuno Y, Ueno T, Kojima S, Ikeuchi H, Ikegami M, Kitada R, Yoshioka KI, Toshimitsu K, Tabata K, Yokoi A, Doi T, Yamamoto N, Owa T, Hamada A, Mano H.  A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency.  NPJ Precis Oncol  2024  8(1):117  PubMed ID: 38789724   DOI: 10.1038/s41698-024-00610-0
21840  Muneer G, Chen CS, Lee TT, Chen BY, Chen YJ.  A Rapid One-Pot Workflow for Sensitive Microscale Phosphoproteomics.  J Proteome Res  2024    PubMed ID: 39038167   DOI: 10.1021/acs.jproteome.3c00862
21865  Matsui Y, Yamada T, Katayama Y, Hirai S, Sawada R, Tachibana Y, Ishida M, Kawachi H, Nakamura R, Nishioka N, Morimoto K, Iwasaku M, Horinaka M, Sakai T, Tokuda S, Takayama K.  Initial AXL and MCL-1 inhibition contributes to abolishing lazertinib tolerance in EGFR-mutant lung cancer cells  Cancer Sci  2024  Jul 22  PubMed ID: 39039802   DOI: 10.1111/cas.16292
21873  Nakamura R, Yamada T, Tokuda S, Morimoto K, Katayama Y, Matsui Y, Hirai S, Ishida M, Kawachi H, Sawada R, Tachibana Y, Osoegawa A, Horinaka M, Sakai T, Yasuhiro T, Kozaki R, Yano S, Takayama K.  Triple combination therapy comprising osimertinib, an AXL inhibitor, and an FGFR inhibitor improves the efficacy of EGFR-mutated non-small cell lung cancer.  Cancer Lett  2024  598:217124  PubMed ID: 39059573   DOI: 10.1016/j.canlet.2024.217124
22056  Geng L, Matsumoto M, Yao F, Umino M, Kamiya M, Mukai H, Kawakami S.  Microfluidic post-insertion of polyethylene glycol lipids and KK or RGD high functionality and quality lipids in milk-derived extracellular vesicles.  Eur J Pharm Sci  2024  106929  PubMed ID: 39389168   DOI: 10.1016/j.ejps.2024.106929
22127  Kim Y, Oh HC, Lee S, Kim HH.  Saturation profiling of drug-resistant genetic variants using prime editing.  Nat Biotechnol  2024    PubMed ID: 39533107   DOI: 10.1038/s41587-024-02465-z
17817  Ohkawa Y, Kitano M, Maeda K, Nakano M, Kanto N, Kizuka Y, Seike M, Azuma A, Yamaguchi Y, Ookawara T, Miyoshi E, Taniguchi N.  Core Fucosylation Is Required for the Secretion of and the Enzymatic Activity of SOD3 in Nonsmall-Cell Lung Cancer Cells  Antioxid Redox Signal  2023  Mar 6  PubMed ID: 36606688   DOI: 10.1089/ars.2022.0010
19676  Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR.  Microfluidics-free single-cell genomics with templated emulsification  Nat Biotechnol  2023  41(11):1557-1566  PubMed ID: 36879006   DOI: 10.1038/s41587-023-01685-z
19697  Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim YH, Konishi E, Itoh K, Takayama K.  Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors  JTO Clin Res Rep  2023  4(6):100525  PubMed ID: 37426308   DOI: 10.1016/j.jtocrr.2023.100525
19731  Kosai K, Masuda T, Kitagawa A, Tobo T, Ono Y, Ando Y, Takahashi J, Haratake N, Kohno M, Takenaka T, Yoshizumi T, Mimori K.  Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma  Ann Surg Oncol  2023  30(12):7538-7548  PubMed ID: 37477745   DOI: 10.1245/s10434-023-13864-y
19976  Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK.  Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer  J Med Chem  2023  Dec 17  PubMed ID: 38105611   DOI: 10.1021/acs.jmedchem.3c01493
20946  Takumi Y, Arai S, Suzuki C, Fukuda K, Nishiyama A, Takeuchi S, Sato H, Matsumoto K, Sugio K, Yano S.  MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements.  Cancer Med  2023  12(5):5809-5820  PubMed ID: 36416133   DOI: 10.1002/cam4.5342
21119  Tokumo K, Masuda T, Nakashima T, Namba M, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Miyata Y, Okada M, Hamada H, Hattori N.  Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial-Mesenchymal Transition.  Cancers (Basel)  2023  15(4)  PubMed ID: 36831438   DOI: 10.3390/cancers15041092
21131  Konishi H, Haga Y, Lin Y, Tsujino H, Higashisaka K, Tsutsumi Y.  Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis.  Biochem Biophys Res Commun  2023  641:116-122  PubMed ID: 36527745   DOI: 10.1016/j.bbrc.2022.12.029
21136  Sumimoto H, Takano A, Igarashi T, Hanaoka J, Teramoto K, Daigo Y.  Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma.  Sci Rep  2023  13(1):5087  PubMed ID: 36991099   DOI: 10.1038/s41598-023-32177-4
21224  Kim M, Kim S, Yim J, Keam B, Kim TM, Jeon YK, Kim DW, Heo DS.  Targeting CD73 to Overcomes Resistance to First-Generation EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.  Cancer Res Treat  2023    PubMed ID: 37218137   DOI: 10.4143/crt.2023.311
17574  Suzuki C, Nishiyama A, Arai S, Tange S, Tajima A, Tanimoto A, Fukuda K, Takumi Y, Kotani H, Takeuchi S, Yanagimura N, Ohtsubo K, Yamamoto N, Omori K, Yano S.  Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells  Cancer Sci  2022  113(7):2323-2335  PubMed ID: 35363931   DOI: 10.1111/cas.15354
20516  Fan D, Yang Y, Zhang W.  A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells.  BMC Pulm Med  2022  22(1):27  PubMed ID: 34996416   DOI: 10.1186/s12890-021-01731-z
20523  Gebreyesus ST, Siyal AA, Kitata RB, Chen ES, Enkhbayar B, Angata T, Lin KI, Chen YJ, Tu HL.  Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry.  Nat Commun  2022  13(1):37  PubMed ID: 35013269   DOI: 10.1038/s41467-021-27778-4
20529  Katayama Y, Yamada T, Tokuda S, Okura N, Nishioka N, Morimoto K, Tanimura K, Morimoto Y, Iwasaku M, Horinaka M, Sakai T, Kita K, Yano S, Takayama K.  Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells.  Cancer Med  2022  11(4):944-955  PubMed ID: 35029047   DOI: 10.1002/cam4.4504
20595  Matsushige T, Sakabe T, Umekita Y.  Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line.  Yonago Acta Med  2022  65(1):44-52  PubMed ID: 35221759   DOI: 10.33160/yam.2022.02.006
16503  Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H.  m 6 A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer  Cancer Gene Ther  2022  Mar 22  PubMed ID: 35318440   DOI: 10.1038/s41417-022-00451-8
16726  Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS.  Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists  Mol Cancer Ther  2022  21(4):594-606  PubMed ID: 35086954   DOI: 10.1158/1535-7163.MCT-21-0532
16854  Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura  Anti-TGF-β1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model  Molecular Therapy - Nucleic Acids  2022  29:969-978  PubMed ID: 36189081   DOI: 10.1016/j.omtn.2022.06.001
20821  Li C, Zheng H, Xiong J, Huang Y, Li H, Jin H, Ai S, Wang Y, Su T, Sun G, Xiao X, Fu T, Wang Y, Gao X, Liang P.  miR-596-3p suppresses brain metastasis of non-small cell lung cancer by modulating YAP1 and IL-8.  Cell Death Dis  2022  13(8):699  PubMed ID: 35961957   DOI: 10.1038/s41419-022-05062-7
20848  Satoh K, Sakai S, Nishizuka M.  Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-β-induced EMT in human lung adenocarcinoma.  Biochem Biophys Rep  2022  32:101346  PubMed ID: 36120491   DOI: 10.1016/j.bbrep.2022.101346
20859  Onishi T, Takashima T, Kurashige M, Ohshima K, Morii E.  Mutually exclusive expression of EZH2 and H3K27me3 in non-small cell lung carcinoma.  Pathol Res Pract  2022  238:154071  PubMed ID: 35985089   DOI: 10.1016/j.prp.2022.154071
20935  Deng H, Lei Q, Wang C, Wang Z, Chen H, Wang G, Yang N, Huang D, Yu Q, Yao M, Xiao X, Zhu G, Cheng C, Li Y, Li F, Tian P, Li W.  A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations.  Nat Commun  2022  13(1):6944  PubMed ID: 36376325   DOI: 10.1038/s41467-022-34627-5
21853  Yuki Oka, Larina Tzu-Wei Shen, Tomoko Mori, Takumi Iwamura, Philippe Leproux, Satoshi Matsusaka, Hideaki Kano  Label-free visualization of cellular response to molecularly targeted agents using multiplex coherent anti-Stokes Raman scattering and third harmonic generation microscopy  Applied Physics Express  2022  15:102001    DOI: 10.35848/1882-0786/ac8d47
20104  Abe K, Kanehira M, Ohkouchi S, Kumata S, Suzuki Y, Oishi H, Noda M, Sakurada A, Miyauchi E, Fujiwara T, Harigae H, Okada Y.  Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer.  Cancer Med  2021    PubMed ID: 33826244   DOI: 10.1002/cam4.3852
14291  Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, Suzuki K, Yanagisawa K, Suzuki M, Fujishita T, Yamaguchi T, Takahashi M, Takahashi T.  Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator  Cancer Sci  2021  112(4):1614-1623  PubMed ID: 33506575   DOI: 10.1111/cas.14825
14368  Khaledian B, Taguchi A, Shin-Ya K, Kondo-Ida L, Kagaya N, Suzuki M, Kajino T, Yamaguchi T, Shimada Y, Takahashi T.  Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma  Cancer Sci  2021  112(3):1225-1234  PubMed ID: 33370472   DOI: 10.1111/cas.14786
20304  Nakasone S, Suzuki A, Okazaki H, Onodera K, Zenkoh J, Ishii G, Suzuki Y, Tsuboi M, Tsuchihara K.  Predictive markers based on transcriptome modules for vinorelbine-based adjuvant chemotherapy for lung adenocarcinoma patients.  Lung Cancer  2021  158:115-125  PubMed ID: 34157583   DOI: 10.1016/j.lungcan.2021.06.011
20365  He W, Qin M, Cai Y, Gao X, Cao S, Wang Z, Chen H, Xu R.  Downregulation of HOXC6 by miR-27a ameliorates gefitinib resistance in non-small cell lung cancer.  Am J Cancer Res  2021  11(9):4329-4346  PubMed ID: 34659890  
15836  Nanamiya R, Saito-Koyama R, Miki Y, Inoue C, Asavasupreechar T, Abe J, Sato I, Sasano H.  EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer  Int J Mol Sci  2021  22(16):8522  PubMed ID: 34445227   DOI: 10.3390/ijms22168522
15839  Poels KE, Schoenfeld AJ, Makhnin A, Tobi Y, Wang Y, Frisco-Cabanos H, Chakrabarti S, Shi M, Napoli C, McDonald TO, Tan W, Hata A, Weinrich SL, Yu HA, Michor F.  dentification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer  Nat Commun  2021  12(1):3697  PubMed ID: 34140482   DOI: 10.1038/s41467-021-23912-4
15840  Fukuda K, Otani S, Takeuchi S, Arai S, Nanjo S, Tanimoto A, Nishiyama A, Naoki K, Yano S.  Trametinib overcomes KRAS-G12V-induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR-mutant lung cancer  Cancer Sci  2021  112(9):3784-3795  PubMed ID: 34145930   DOI: 10.1111/cas.15035
15846  Kawana S, Saito R, Miki Y, Kimura Y, Abe J, Sato I, Endo M, Sugawara S, Sasano H.  Suppression of tumor immune microenvironment via microRNA-1 after epidermal growth factor receptor-tyrosine kinase inhibitor resistance acquirement in lung adenocarcinoma  Cancer Med  2021  10(2):718-727  PubMed ID: 33305905   DOI: 10.1002/cam4.3639
15883  Xue L, Gao X, Zhang H, Tang J, Wang Q, Li F, Li X, Yu X, Lu Z, Huang Y, Tang R, Yang W.  Antiangiogenic antibody BD0801 combined with immune checkpoint inhibitors achieves synergistic antitumor activity and affects the tumor microenvironment  BMC Cancer  2021  21(1):1134  PubMed ID: 34686154   DOI: 10.1186/s12885-021-08859-5
16219  Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto  Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma  Cancer Sci  2021  112(12):5114-5126  PubMed ID: 34628698   DOI: 10.1111/cas.15160
16281  Nachankar A, Oike T, Hanaoka H, Kanai A, Sato H, Yoshida Y, Obinata H, Sakai M, Osu N, Hirota Y, Takahashi A, Shibata A, Ohno T.  64 Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity  Cancers (Basel)  2021  13(24):6159  PubMed ID: 34944777   DOI: 10.3390/cancers13246159
20624  Nozaki M, Nishizuka M.  Repression of RhoJ expression promotes TGF-β-mediated EMT in human non-small-cell lung cancer A549cells.  Biochem Biophys Res Commun  2021  566:94-100  PubMed ID: 34119829   DOI: 10.1016/j.bbrc.2021.06.004
16516  Tsuchiya K, Yoshimura K, Inoue Y, Iwashita Y, Yamada H, Kawase A, Watanabe T, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H.  YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer  Oncoimmunology  2021  10(1):1962656  PubMed ID: 34408926   DOI: 10.1080/2162402X.2021.1962656
18105  Liu J, Han X, Chen L, Han D, Mu X, Hu X, Wu H, Wu H, Liu W, Zhao Y.  TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma  Aging (Albany NY)  2020  12(20):20308-20331  PubMed ID: 33091876   DOI: 10.18632/aging.103804
7054  Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM, Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S.  Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer.  J Thorac Oncol  2020  15(5):752-765  PubMed ID: 31972351   DOI: 10.1016/j.jtho.2020.01.001
11955  Ren T, Fan XX, Wang MF, Duan FG, Wei CL, Li RZ, Jiang ZB, Wang YW, Yao XJ, Chen MW, Tang YJ, Leung EL.  miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway.  Int. J. Oncol.  2020    PubMed ID: 31894264   DOI: 10.3892/ijo.2019.4940
12050  Azuma Y, Yokobori T, Mogi A, Yajima T, Kosaka T, Iijima M, Shimizu K, Shirabe K, Kuwano H.  Cancer exosomal microRNAs from gefitinib-resistant lung cancer cells cause therapeutic resistance in gefitinib-sensitive cells.  Surg. Today  2020    PubMed ID: 32052182   DOI: 10.1007/s00595-020-01976-x
12085  Lin Y, Higashisaka K, Shintani T, Maki A, Hanamuro S, Haga Y, Maeda S, Tsujino H, Nagano K, Fujio Y, Tsutsumi Y.  Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells.  Sci Rep  2020    PubMed ID: 32179851   DOI: 10.1038/s41598-020-61727-3
12089  Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, Hiramoto M, Tsukahara K, Miyazawa K.  Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin.  Biochem Biophys Rep  2020    PubMed ID: 32195376   DOI: 10.1016/j.bbrep.2020.100750
13153  Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C.  Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing.  Biomedicines  2020    PubMed ID: 32764319   DOI: 10.3390/biomedicines8080273
13224  Wang R, Yamada T, Kita K, Taniguchi H, Arai S, Fukuda K, Terashima M, Ishimura A, Nishiyama A, Tanimoto A, Takeuchi S, Ohtsubo K, Yamashita K, Yamano T, Yoshimura A, Takayama K, Kaira K, Taniguchi Y, Atagi S, Uehara H, Hanayama R, Matsumoto I, Han X, Matsumoto K, Wang W, Suzuki T, Yano S.  Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer.  Nat Commun  2020    PubMed ID: 32929081   DOI: 10.1038/s41467-020-18442-4
13283  Arai S, Takeuchi S, Fukuda K, Tanimoto A, Nishiyama A, Konishi H, Takagi A, Takahashi H, Ong ST, Yano S.  Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism.  J Med Invest  2020    PubMed ID: 33148913   DOI: 10.2152/jmi.67.343
13543  Okuno D, Sugiura Y, Sakamoto N, Tagod MSO, Iwasaki M, Noda S, Tamura A, Senju H, Umeyama Y, Yamaguchi H, Suematsu M, Morita CT, Tanaka Y, Mukae H.  Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells  Front Immunol  2020  11:1405  PubMed ID: 32793196   DOI: 10.3389/fimmu.2020.01405
13922  Kim H, Ishibashi K, Iijima M, Kuroda S, Nakamura C.  Influence of Nivolumab for Intercellular Adhesion Force between a T Cell and a Cancer Cell Evaluated by AFM Force Spectroscopy  Sensors (Basel)  2020  20(19):5723  PubMed ID: 33050090   DOI: 10.3390/s20195723
14793  Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S, Kitazaki T, Nishiyama A, Iwasaku M, Kaneko Y, Uchino J, Uehara H, Horinaka M, Sakai T, Tanaka K, Kozaki R, Yano S, Takayama K.  ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer  Clin Cancer Res  2020  26(9):2244-2256  PubMed ID: 31953310   DOI: 10.1158/1078-0432.CCR-19-2321
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15825  Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment  Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment  Cancer Sci  2014  105(10):1236-44  PubMed ID: 25154680   DOI: 10.1111/cas.12503
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15837  神山 伸,土沼 侑佳,塩沢 浩太,萩原 真,曽根 英行  SLC35F2 の発現状態及び B 群ビタミンが肺腺がん細胞の ゲフィチニブ感受性に及ぼす影響  Trace Nutrients Research  2016  30:80−86   



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