CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB4455 : PC-9]

22567 Kumada T, Mimae T, Tsubokawa N, Kushitani K, Takeshima Y, Miyata Y, Okada M. Role of guanylate-binding protein 1 in the proliferation of invasive lung adenocarcinoma cells. Front Oncol 2025 15:1434249 PubMed ID: 40018406 DOI: 10.3389/fonc.2025.1434249

22754 Lyu H, Ishimura A, Suzuki R, Buyanbat K, Batbayar G, Meguro-Horike M, Horike SI, Yano S, Suzuki T. HDAC5, an early osimertinib-responsive gene, is a novel therapeutic target for the drug resistance in EGFR-mutant lung adenocarcinoma cells. Biochem Biophys Rep 2025 42:102016 PubMed ID: 40290805 DOI: 10.1016/j.bbrep.2025.102016

22971 Fukuda K, Nanjo S, Takeuchi S, Chakrabarti T, Brown T, Dev Sahadevan SW, Arai S, Sato S, Kotani H, Nishiyama A, Sakaguchi H, Ohtsubo K, Taniguchi H, Blakely CM, Bivona TG, Yano S. Targeting WEE1 to overcome ARID1A mutation-driven osimertinib resistance in EGFR-mutant lung cancer. J Thorac Oncol 2025 PubMed ID: 40518016 DOI: 10.1016/j.jtho.2025.06.007

22979 Miyata-Morita K, Kawashima A, Kiriya M, Dejima H, Saito K, Sakao Y, Suzuki K, Sasajima Y, Morita S. Perilipin 2 mediates progression of lung adenocarcinoma by modulating lipid metabolism. Am J Pathol 2025 PubMed ID: 40541711 DOI: 10.1016/j.ajpath.2025.05.016

21677 Kim S, Lee Y, Song BR, Sim H, Kang EH, Hwang M, Yu N, Hong S, Park C, Ahn BC, Lim EJ, Hwang KH, Park SY, Choi JH, Lee GK, Han JY. Drug Response of Patient-Derived Lung Cancer Cells Predicts Clinical Outcomes of Targeted Therapy. Cancers (Basel) 2024 16(4) PubMed ID: 38398169 DOI: 10.3390/cancers16040778

21706 Ando S, Tanaka K, Matsumoto M, Oyama Y, Tomabechi Y, Yamagata A, Shirouzu M, Nakagawa R, Okimoto N, Taiji M, Sato K, Ohama T. The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction. J Biol Chem 2024 107277 PubMed ID: 38588804 DOI: 10.1016/j.jbc.2024.107277

21743 Zha L, Matsu-Ura T, Sluka JP, Murakawa T, Tsuta K. Morphological basis of the lung adenocarcinoma subtypes. iScience 2024 27(5):109742 PubMed ID: 38706836 DOI: 10.1016/j.isci.2024.109742

21749 Kohsaka S, Yagishita S, Shirai Y, Matsuno Y, Ueno T, Kojima S, Ikeuchi H, Ikegami M, Kitada R, Yoshioka KI, Toshimitsu K, Tabata K, Yokoi A, Doi T, Yamamoto N, Owa T, Hamada A, Mano H. A molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency. NPJ Precis Oncol 2024 8(1):117 PubMed ID: 38789724 DOI: 10.1038/s41698-024-00610-0

21840 Muneer G, Chen CS, Lee TT, Chen BY, Chen YJ. A Rapid One-Pot Workflow for Sensitive Microscale Phosphoproteomics. J Proteome Res 2024 PubMed ID: 39038167 DOI: 10.1021/acs.jproteome.3c00862

21865 Matsui Y, Yamada T, Katayama Y, Hirai S, Sawada R, Tachibana Y, Ishida M, Kawachi H, Nakamura R, Nishioka N, Morimoto K, Iwasaku M, Horinaka M, Sakai T, Tokuda S, Takayama K. Initial AXL and MCL-1 inhibition contributes to abolishing lazertinib tolerance in EGFR-mutant lung cancer cells Cancer Sci 2024 Jul 22 PubMed ID: 39039802 DOI: 10.1111/cas.16292

21873 Nakamura R, Yamada T, Tokuda S, Morimoto K, Katayama Y, Matsui Y, Hirai S, Ishida M, Kawachi H, Sawada R, Tachibana Y, Osoegawa A, Horinaka M, Sakai T, Yasuhiro T, Kozaki R, Yano S, Takayama K. Triple combination therapy comprising osimertinib, an AXL inhibitor, and an FGFR inhibitor improves the efficacy of EGFR-mutated non-small cell lung cancer. Cancer Lett 2024 598:217124 PubMed ID: 39059573 DOI: 10.1016/j.canlet.2024.217124

22056 Geng L, Matsumoto M, Yao F, Umino M, Kamiya M, Mukai H, Kawakami S. Microfluidic post-insertion of polyethylene glycol lipids and KK or RGD high functionality and quality lipids in milk-derived extracellular vesicles. Eur J Pharm Sci 2024 106929 PubMed ID: 39389168 DOI: 10.1016/j.ejps.2024.106929

22127 Kim Y, Oh HC, Lee S, Kim HH. Saturation profiling of drug-resistant genetic variants using prime editing. Nat Biotechnol 2024 PubMed ID: 39533107 DOI: 10.1038/s41587-024-02465-z

22340 Yamamoto H, Hanamatsu Y, Saigo C, Takeuchi T, Iwata H. SOX17 expression in tumor-penetrating vessels in relation to CD8+ T-cell infiltration in cancer stroma niches Thorac Cancer 2024 15(32):2319-2326 PubMed ID: 39385307 DOI: 10.1111/1759-7714.15464

22393 Sasaki M, Ogiwara H.Sasaki M, Ogiwara H.Sasaki M, Ogiwara H.Sasaki M, Ogiwara H. Efficacy of glutathione inhibitor eprenetapopt against the vulnerability of glutathione metabolism in SMARCA4-, SMARCB1- and PBRM1-deficient cancer cells. Sci Rep 2024 PubMed ID: 39732845 DOI: 10.1038/s41598-024-82753-5

22524 Kasai F, Fukushima M, Miyagi Y, Nakamura Y. Genetic diversity among the present Japanese population: evidence from genotyping of human cell lines established in Japan Hum Cell 2024 37(4):944-950 PubMed ID: 38639832 DOI: 10.1007/s13577-024-01055-0

22814 Shintani T, Shun YT, Toyozumi Y, Ikemura K, Shiroyama T, Nagatomo I, Jingushi K, Takeda Y, Kumanogoh A, Okuda M. MicroRNA-130a-3p regulates osimertinib resistance by targeting runt-related transcription factor 3 in lung adenocarcinoma Sci Rep 2024 14(1):24429 PubMed ID: 39424918 DOI: 10.1038/s41598-024-76196-1

22982 Kanayama M, Yoneda K, Kuwata T, Mori M, Manabe T, Oyama R, Matsumiya H, Takenaka M, Kuroda K, Ohnaga T, Tanaka F. Enhanced capture system for mesenchymal‑type circulating tumor cells using a polymeric microfluidic device 'CTC‑Chip' incorporating cell‑surface vimentin Oncol Rep 2024 52(5):156 PubMed ID: 39364763 DOI: 10.3892/or.2024.8815

17817 Ohkawa Y, Kitano M, Maeda K, Nakano M, Kanto N, Kizuka Y, Seike M, Azuma A, Yamaguchi Y, Ookawara T, Miyoshi E, Taniguchi N. Core Fucosylation Is Required for the Secretion of and the Enzymatic Activity of SOD3 in Nonsmall-Cell Lung Cancer Cells Antioxid Redox Signal 2023 Mar 6 PubMed ID: 36606688 DOI: 10.1089/ars.2022.0010

19676 Clark IC, Fontanez KM, Meltzer RH, Xue Y, Hayford C, May-Zhang A, D'Amato C, Osman A, Zhang JQ, Hettige P, Ishibashi JSA, Delley CL, Weisgerber DW, Replogle JM, Jost M, Phong KT, Kennedy VE, Peretz CAC, Kim EA, Song S, Karlon W, Weissman JS, Smith CC, Gartner ZJ, Abate AR. Microfluidics-free single-cell genomics with templated emulsification Nat Biotechnol 2023 41(11):1557-1566 PubMed ID: 36879006 DOI: 10.1038/s41587-023-01685-z

19697 Nakamura R, Fujii H, Yamada T, Matsui Y, Yaoi T, Honda M, Tanaka N, Miyagawa-Hayashino A, Yoshimura A, Morimoto K, Iwasaku M, Tokuda S, Kim YH, Konishi E, Itoh K, Takayama K. Analysis of Tumor Heterogeneity Through AXL Activation in Primary Resistance to EGFR Tyrosine Kinase Inhibitors JTO Clin Res Rep 2023 4(6):100525 PubMed ID: 37426308 DOI: 10.1016/j.jtocrr.2023.100525

19731 Kosai K, Masuda T, Kitagawa A, Tobo T, Ono Y, Ando Y, Takahashi J, Haratake N, Kohno M, Takenaka T, Yoshizumi T, Mimori K. Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma Ann Surg Oncol 2023 30(12):7538-7548 PubMed ID: 37477745 DOI: 10.1245/s10434-023-13864-y

19976 Gunasekaran P, Hwang YS, Lee GH, Park J, Kim JG, La YK, Park NY, Kothandaraman R, Yim MS, Choi J, Kim HN, Park IY, Lee SJ, Kim MH, Cha-Molstad H, Shin SY, Ryu EK, Bang JK. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer J Med Chem 2023 Dec 17 PubMed ID: 38105611 DOI: 10.1021/acs.jmedchem.3c01493

20946 Takumi Y, Arai S, Suzuki C, Fukuda K, Nishiyama A, Takeuchi S, Sato H, Matsumoto K, Sugio K, Yano S. MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements. Cancer Med 2023 12(5):5809-5820 PubMed ID: 36416133 DOI: 10.1002/cam4.5342

21119 Tokumo K, Masuda T, Nakashima T, Namba M, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Miyata Y, Okada M, Hamada H, Hattori N. Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial-Mesenchymal Transition. Cancers (Basel) 2023 15(4) PubMed ID: 36831438 DOI: 10.3390/cancers15041092

21131 Konishi H, Haga Y, Lin Y, Tsujino H, Higashisaka K, Tsutsumi Y. Osimertinib-tolerant lung cancer cells are susceptible to ferroptosis. Biochem Biophys Res Commun 2023 641:116-122 PubMed ID: 36527745 DOI: 10.1016/j.bbrc.2022.12.029

21136 Sumimoto H, Takano A, Igarashi T, Hanaoka J, Teramoto K, Daigo Y. Oncogenic epidermal growth factor receptor signal-induced histone deacetylation suppresses chemokine gene expression in human lung adenocarcinoma. Sci Rep 2023 13(1):5087 PubMed ID: 36991099 DOI: 10.1038/s41598-023-32177-4

21224 Kim M, Kim S, Yim J, Keam B, Kim TM, Jeon YK, Kim DW, Heo DS. Targeting CD73 to Overcomes Resistance to First-Generation EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer. Cancer Res Treat 2023 PubMed ID: 37218137 DOI: 10.4143/crt.2023.311

22275 Jin G, Ma M, Yang C, Zhen L, Feng M. Salidroside suppresses the multiple oncogenic activates and immune escape of lung adenocarcinoma through the circ_0009624-mediated PD-L1 pathway Thorac Cancer 2023 14(24):2493-2503 PubMed ID: 37423604 DOI: 10.1111/1759-7714.15034

17574 Suzuki C, Nishiyama A, Arai S, Tange S, Tajima A, Tanimoto A, Fukuda K, Takumi Y, Kotani H, Takeuchi S, Yanagimura N, Ohtsubo K, Yamamoto N, Omori K, Yano S. Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells Cancer Sci 2022 113(7):2323-2335 PubMed ID: 35363931 DOI: 10.1111/cas.15354

19448 Choi YR, Cho Y, Park SY, Kim S, Shin M, Choi Y, Shin DH, Han JY, Lee Y. Early On-Treatment Prediction of the Mechanisms of Acquired Resistance to EGFR Tyrosine Kinase Inhibitors Cancers (Basel) 2022 14(6):1512 PubMed ID: 35326664 DOI: 10.3390/cancers14061512

20516 Fan D, Yang Y, Zhang W. A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells. BMC Pulm Med 2022 22(1):27 PubMed ID: 34996416 DOI: 10.1186/s12890-021-01731-z

20523 Gebreyesus ST, Siyal AA, Kitata RB, Chen ES, Enkhbayar B, Angata T, Lin KI, Chen YJ, Tu HL. Streamlined single-cell proteomics by an integrated microfluidic chip and data-independent acquisition mass spectrometry. Nat Commun 2022 13(1):37 PubMed ID: 35013269 DOI: 10.1038/s41467-021-27778-4

20529 Katayama Y, Yamada T, Tokuda S, Okura N, Nishioka N, Morimoto K, Tanimura K, Morimoto Y, Iwasaku M, Horinaka M, Sakai T, Kita K, Yano S, Takayama K. Heterogeneity among tumors with acquired resistance to EGFR tyrosine kinase inhibitors harboring EGFR-T790M mutation in non-small cell lung cancer cells. Cancer Med 2022 11(4):944-955 PubMed ID: 35029047 DOI: 10.1002/cam4.4504

20595 Matsushige T, Sakabe T, Umekita Y. Investigation of the Subcellular Localization-Dependent Anti- or Pro-Tumor Functions of Maspin in Human Lung Adenocarcinoma Cell Line. Yonago Acta Med 2022 65(1):44-52 PubMed ID: 35221759 DOI: 10.33160/yam.2022.02.006

16503 Tsuchiya K, Yoshimura K, Iwashita Y, Inoue Y, Ohta T, Watanabe H, Yamada H, Kawase A, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H. m 6 A demethylase ALKBH5 promotes tumor cell proliferation by destabilizing IGF2BPs target genes and worsens the prognosis of patients with non-small-cell lung cancer Cancer Gene Ther 2022 Mar 22 PubMed ID: 35318440 DOI: 10.1038/s41417-022-00451-8

16726 Grinkevitch V, Wappett M, Crawford N, Price S, Lees A, McCann C, McAllister K, Prehn J, Young J, Bateson J, Gallagher L, Michaut M, Iyer V, Chatzipli A, Barthorpe S, Ciznadija D, Sloma I, Wesa A, Tice DA, Wessels L, Garnett M, Longley DB, McDermott U, McDade SS. Functional Genomic Identification of Predictors of Sensitivity and Mechanisms of Resistance to Multivalent Second-Generation TRAIL-R2 Agonists Mol Cancer Ther 2022 21(4):594-606 PubMed ID: 35086954 DOI: 10.1158/1535-7163.MCT-21-0532

16854 Masaki Takahashi, Yoshifumi Hashimoto, Yoshikazu Nakamura Anti-TGF-β1 aptamer enhances therapeutic effect of tyrosine kinase inhibitor, gefitinib, on non-small cell lung cancer in xenograft model Molecular Therapy - Nucleic Acids 2022 29:969-978 PubMed ID: 36189081 DOI: 10.1016/j.omtn.2022.06.001

20821 Li C, Zheng H, Xiong J, Huang Y, Li H, Jin H, Ai S, Wang Y, Su T, Sun G, Xiao X, Fu T, Wang Y, Gao X, Liang P. miR-596-3p suppresses brain metastasis of non-small cell lung cancer by modulating YAP1 and IL-8. Cell Death Dis 2022 13(8):699 PubMed ID: 35961957 DOI: 10.1038/s41419-022-05062-7

20848 Satoh K, Sakai S, Nishizuka M. Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-β-induced EMT in human lung adenocarcinoma. Biochem Biophys Rep 2022 32:101346 PubMed ID: 36120491 DOI: 10.1016/j.bbrep.2022.101346

20859 Onishi T, Takashima T, Kurashige M, Ohshima K, Morii E. Mutually exclusive expression of EZH2 and H3K27me3 in non-small cell lung carcinoma. Pathol Res Pract 2022 238:154071 PubMed ID: 35985089 DOI: 10.1016/j.prp.2022.154071

20935 Deng H, Lei Q, Wang C, Wang Z, Chen H, Wang G, Yang N, Huang D, Yu Q, Yao M, Xiao X, Zhu G, Cheng C, Li Y, Li F, Tian P, Li W. A fluorogenic probe for predicting treatment response in non-small cell lung cancer with EGFR-activating mutations. Nat Commun 2022 13(1):6944 PubMed ID: 36376325 DOI: 10.1038/s41467-022-34627-5

21853 Yuki Oka, Larina Tzu-Wei Shen, Tomoko Mori, Takumi Iwamura, Philippe Leproux, Satoshi Matsusaka, Hideaki Kano Label-free visualization of cellular response to molecularly targeted agents using multiplex coherent anti-Stokes Raman scattering and third harmonic generation microscopy Applied Physics Express 2022 15:102001 DOI: 10.35848/1882-0786/ac8d47

22256 Takahashi G, Kondo D, Maeda M, Morishita Y, Miyaoka Y. Genome editing is induced in a binary manner in single human cells iScience 2022 25(12):105619 PubMed ID: 36483018 DOI: 10.1016/j.isci.2022.105619

22542 Xiao RR, Jin L, Xie N, Luo P, Gao W, Tu P, Ai X. Establishment and large-scale validation of a three-dimensional tumor model on an array chip for anticancer drug evaluation Front Pharmacol 2022 13:1032975 PubMed ID: 36313330 DOI: 10.3389/fphar.2022.1032975

20104 Abe K, Kanehira M, Ohkouchi S, Kumata S, Suzuki Y, Oishi H, Noda M, Sakurada A, Miyauchi E, Fujiwara T, Harigae H, Okada Y. Targeting stanniocalcin-1-expressing tumor cells elicits efficient antitumor effects in a mouse model of human lung cancer. Cancer Med 2021 PubMed ID: 33826244 DOI: 10.1002/cam4.3852

14291 Isomura H, Taguchi A, Kajino T, Asai N, Nakatochi M, Kato S, Suzuki K, Yanagisawa K, Suzuki M, Fujishita T, Yamaguchi T, Takahashi M, Takahashi T. Conditional Ror1 knockout reveals crucial involvement in lung adenocarcinoma development and identifies novel HIF-1α regulator Cancer Sci 2021 112(4):1614-1623 PubMed ID: 33506575 DOI: 10.1111/cas.14825

14368 Khaledian B, Taguchi A, Shin-Ya K, Kondo-Ida L, Kagaya N, Suzuki M, Kajino T, Yamaguchi T, Shimada Y, Takahashi T. Inhibition of heat shock protein 90 destabilizes receptor tyrosine kinase ROR1 in lung adenocarcinoma Cancer Sci 2021 112(3):1225-1234 PubMed ID: 33370472 DOI: 10.1111/cas.14786

20304 Nakasone S, Suzuki A, Okazaki H, Onodera K, Zenkoh J, Ishii G, Suzuki Y, Tsuboi M, Tsuchihara K. Predictive markers based on transcriptome modules for vinorelbine-based adjuvant chemotherapy for lung adenocarcinoma patients. Lung Cancer 2021 158:115-125 PubMed ID: 34157583 DOI: 10.1016/j.lungcan.2021.06.011

20365 He W, Qin M, Cai Y, Gao X, Cao S, Wang Z, Chen H, Xu R. Downregulation of HOXC6 by miR-27a ameliorates gefitinib resistance in non-small cell lung cancer. Am J Cancer Res 2021 11(9):4329-4346 PubMed ID: 34659890

15836 Nanamiya R, Saito-Koyama R, Miki Y, Inoue C, Asavasupreechar T, Abe J, Sato I, Sasano H. EphB4 as a Novel Target for the EGFR-Independent Suppressive Effects of Osimertinib on Cell Cycle Progression in Non-Small Cell Lung Cancer Int J Mol Sci 2021 22(16):8522 PubMed ID: 34445227 DOI: 10.3390/ijms22168522

15839 Poels KE, Schoenfeld AJ, Makhnin A, Tobi Y, Wang Y, Frisco-Cabanos H, Chakrabarti S, Shi M, Napoli C, McDonald TO, Tan W, Hata A, Weinrich SL, Yu HA, Michor F. dentification of optimal dosing schedules of dacomitinib and osimertinib for a phase I/II trial in advanced EGFR-mutant non-small cell lung cancer Nat Commun 2021 12(1):3697 PubMed ID: 34140482 DOI: 10.1038/s41467-021-23912-4

15840 Fukuda K, Otani S, Takeuchi S, Arai S, Nanjo S, Tanimoto A, Nishiyama A, Naoki K, Yano S. Trametinib overcomes KRAS-G12V-induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR-mutant lung cancer Cancer Sci 2021 112(9):3784-3795 PubMed ID: 34145930 DOI: 10.1111/cas.15035

15846 Kawana S, Saito R, Miki Y, Kimura Y, Abe J, Sato I, Endo M, Sugawara S, Sasano H. Suppression of tumor immune microenvironment via microRNA-1 after epidermal growth factor receptor-tyrosine kinase inhibitor resistance acquirement in lung adenocarcinoma Cancer Med 2021 10(2):718-727 PubMed ID: 33305905 DOI: 10.1002/cam4.3639

15883 Xue L, Gao X, Zhang H, Tang J, Wang Q, Li F, Li X, Yu X, Lu Z, Huang Y, Tang R, Yang W. Antiangiogenic antibody BD0801 combined with immune checkpoint inhibitors achieves synergistic antitumor activity and affects the tumor microenvironment BMC Cancer 2021 21(1):1134 PubMed ID: 34686154 DOI: 10.1186/s12885-021-08859-5

16219 Jeongmin Hong, Aya Shiba‐Ishii, Yunjung Kim, Masayuki Noguchi, Noriaki Sakamoto Ovarian carcinoma immunoreactive antigen domain 2 controls mitochondrial apoptosis in lung adenocarcinoma Cancer Sci 2021 112(12):5114-5126 PubMed ID: 34628698 DOI: 10.1111/cas.15160

16281 Nachankar A, Oike T, Hanaoka H, Kanai A, Sato H, Yoshida Y, Obinata H, Sakai M, Osu N, Hirota Y, Takahashi A, Shibata A, Ohno T. 64 Cu-ATSM Predicts Efficacy of Carbon Ion Radiotherapy Associated with Cellular Antioxidant Capacity Cancers (Basel) 2021 13(24):6159 PubMed ID: 34944777 DOI: 10.3390/cancers13246159

20624 Nozaki M, Nishizuka M. Repression of RhoJ expression promotes TGF-β-mediated EMT in human non-small-cell lung cancer A549cells. Biochem Biophys Res Commun 2021 566:94-100 PubMed ID: 34119829 DOI: 10.1016/j.bbrc.2021.06.004

16516 Tsuchiya K, Yoshimura K, Inoue Y, Iwashita Y, Yamada H, Kawase A, Watanabe T, Tanahashi M, Ogawa H, Funai K, Shinmura K, Suda T, Sugimura H. YTHDF1 and YTHDF2 are associated with better patient survival and an inflamed tumor-immune microenvironment in non-small-cell lung cancer Oncoimmunology 2021 10(1):1962656 PubMed ID: 34408926 DOI: 10.1080/2162402X.2021.1962656

18105 Liu J, Han X, Chen L, Han D, Mu X, Hu X, Wu H, Wu H, Liu W, Zhao Y. TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma Aging (Albany NY) 2020 12(20):20308-20331 PubMed ID: 33091876 DOI: 10.18632/aging.103804

7054 Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM, Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S. Osimertinib overcomes alectinib resistance caused by amphiregulin in a leptomeningeal carcinomatosis model of ALK-rearranged lung cancer. J Thorac Oncol 2020 15(5):752-765 PubMed ID: 31972351 DOI: 10.1016/j.jtho.2020.01.001

11955 Ren T, Fan XX, Wang MF, Duan FG, Wei CL, Li RZ, Jiang ZB, Wang YW, Yao XJ, Chen MW, Tang YJ, Leung EL. miR‑20b promotes growth of non‑small cell lung cancer through a positive feedback loop of the Wnt/β‑catenin signaling pathway. Int. J. Oncol. 2020 PubMed ID: 31894264 DOI: 10.3892/ijo.2019.4940

12050 Azuma Y, Yokobori T, Mogi A, Yajima T, Kosaka T, Iijima M, Shimizu K, Shirabe K, Kuwano H. Cancer exosomal microRNAs from gefitinib-resistant lung cancer cells cause therapeutic resistance in gefitinib-sensitive cells. Surg. Today 2020 PubMed ID: 32052182 DOI: 10.1007/s00595-020-01976-x

12085 Lin Y, Higashisaka K, Shintani T, Maki A, Hanamuro S, Haga Y, Maeda S, Tsujino H, Nagano K, Fujio Y, Tsutsumi Y. Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells. Sci Rep 2020 PubMed ID: 32179851 DOI: 10.1038/s41598-020-61727-3

12089 Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, Hiramoto M, Tsukahara K, Miyazawa K. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin. Biochem Biophys Rep 2020 PubMed ID: 32195376 DOI: 10.1016/j.bbrep.2020.100750

13153 Suzuki S, Yamamoto M, Sanomachi T, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C. Doxazosin, a Classic Alpha 1-Adrenoceptor Antagonist, Overcomes Osimertinib Resistance in Cancer Cells via the Upregulation of Autophagy as Drug Repurposing. Biomedicines 2020 PubMed ID: 32764319 DOI: 10.3390/biomedicines8080273

13224 Wang R, Yamada T, Kita K, Taniguchi H, Arai S, Fukuda K, Terashima M, Ishimura A, Nishiyama A, Tanimoto A, Takeuchi S, Ohtsubo K, Yamashita K, Yamano T, Yoshimura A, Takayama K, Kaira K, Taniguchi Y, Atagi S, Uehara H, Hanayama R, Matsumoto I, Han X, Matsumoto K, Wang W, Suzuki T, Yano S. Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer. Nat Commun 2020 PubMed ID: 32929081 DOI: 10.1038/s41467-020-18442-4

13283 Arai S, Takeuchi S, Fukuda K, Tanimoto A, Nishiyama A, Konishi H, Takagi A, Takahashi H, Ong ST, Yano S. Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism. J Med Invest 2020 PubMed ID: 33148913 DOI: 10.2152/jmi.67.343

13543 Okuno D, Sugiura Y, Sakamoto N, Tagod MSO, Iwasaki M, Noda S, Tamura A, Senju H, Umeyama Y, Yamaguchi H, Suematsu M, Morita CT, Tanaka Y, Mukae H. Comparison of a Novel Bisphosphonate Prodrug and Zoledronic Acid in the Induction of Cytotoxicity in Human Vγ2Vδ2 T Cells Front Immunol 2020 11:1405 PubMed ID: 32793196 DOI: 10.3389/fimmu.2020.01405

13922 Kim H, Ishibashi K, Iijima M, Kuroda S, Nakamura C. Influence of Nivolumab for Intercellular Adhesion Force between a T Cell and a Cancer Cell Evaluated by AFM Force Spectroscopy Sensors (Basel) 2020 20(19):5723 PubMed ID: 33050090 DOI: 10.3390/s20195723

14793 Okura N, Nishioka N, Yamada T, Taniguchi H, Tanimura K, Katayama Y, Yoshimura A, Watanabe S, Kikuchi T, Shiotsu S, Kitazaki T, Nishiyama A, Iwasaku M, Kaneko Y, Uchino J, Uehara H, Horinaka M, Sakai T, Tanaka K, Kozaki R, Yano S, Takayama K. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in EGFR-Mutated Non-Small Cell Lung Cancer Clin Cancer Res 2020 26(9):2244-2256 PubMed ID: 31953310 DOI: 10.1158/1078-0432.CCR-19-2321

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14834 Saito R, Miki Y, Abe T, Miyauchi E, Abe J, Nanamiya R, Inoue C, Sato I, Sasano H. 11β hydroxysteroid dehydrogenase 1: a new marker for predicting response to immune-checkpoint blockade therapy in non-small-cell lung carcinoma Br J Cancer 2020 123(1):61-71 PubMed ID: 32336752 DOI: 10.1038/s41416-020-0837-3

22419 Luong NC, Abiko Y, Shibata T, Uchida K, Warabi E, Suzuki M, Noguchi T, Matsuzawa A, Kumagai Y. Redox cycling of 9,10-phenanthrenequinone activates epidermal growth factor receptor signaling through S-oxidation of protein tyrosine phosphatase 1B. J Toxicol Sci 2020 5(12):807 DOI: 10.1016/j.cellsig.2021.110049

17870 Yamaguchi T, Hayashi M, Ida L, Yamamoto M, Lu C, Kajino T, Cheng J, Nakatochi M, Isomura H, Yamazaki M, Suzuki M, Fujimoto T, Takahashi T. ROR1-CAVIN3 interaction required for caveolae-dependent endocytosis and pro-survival signaling in lung adenocarcinoma Oncogene 2019 38(26):5142-5157 PubMed ID: 30894682 DOI: 10.1038/s41388-019-0785-7

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11848 Sanomachi T, Suzuki S, Togashi K, Sugai A, Seino S, Okada M, Yoshioka T, Kitanaka C, Yamamoto M. Spironolactone, a Classic Potassium-Sparing Diuretic, Reduces Survivin Expression and Chemosensitizes Cancer Cells to Non-DNA-Damaging Anticancer Drugs. Cancers (Basel) 2019 PubMed ID: 31614999 DOI: 10.3390/cancers11101550

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12553 Chen L, Zhou Y, Tang X, Yang C, Tian Y, Xie R, Chen T, Yang J, Jing M, Chen F, Wang C, Sun H, Huang Y. EGFR mutation decreases FDG uptake in non‑small cell lung cancer via the NOX4/ROS/GLUT1 axis Int J Oncol 2019 54(1):370-380 PubMed ID: 30431083 DOI: 10.3892/ijo.2018.4626

14275 Suzawa K, Offin M, Lu D, Kurzatkowski C, Vojnic M, Smith RS, Sabari JK, Tai H, Mattar M, Khodos I, de Stanchina E, Rudin CM, Kris MG, Arcila ME, Lockwood WW, Drilon A, Ladanyi M, Somwar R. Activation of KRAS Mediates Resistance to Targeted Therapy in MET Exon 14-mutant Non-small Cell Lung Cancer Clin Cancer Res 2019 25(4):1248-1260 PubMed ID: 30352902 DOI: 10.1158/1078-0432.CCR-18-1640

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14810 Namba K, Shien K, Takahashi Y, Torigoe H, Sato H, Yoshioka T, Takeda T, Kurihara E, Ogoshi Y, Yamamoto H, Soh J, Tomida S, Toyooka S. Activation of AXL as a Preclinical Acquired Resistance Mechanism Against Osimertinib Treatment in EGFR-Mutant Non-Small Cell Lung Cancer Cells Mol Cancer Res 2019 17(2):499-507 PubMed ID: 30463991 DOI: 10.1158/1541-7786.MCR-18-0628

10633 Asaka S, Yoshizawa A, Nakata R, Negishi T, Yamamoto H, Shiina T, Shigeto S, Matsuda K, Kobayashi Y, Honda T. Utility of bronchial lavage fluids for epithelial growth factor receptor mutation assay in lung cancer patients: Comparison between cell pellets, cell blocks and matching tissue specimens. Oncol Lett 2018 15:1469-1474 PubMed ID: 29399190 DOI: 10.3892/ol.2017.7464

10679 Yoneda K, Chikaishi Y, Kuwata T, Ohnaga T, Tanaka F. Capture of mesothelioma cells with 'universal' CTC-chip. Oncol Lett 2018 15:2635-2640 PubMed ID: 29434985 DOI: 10.3892/ol.2017.7619

10706 Bao H, Bai T, Takata K, Yokobori T, Ohnaga T, Hisada T, Maeno T, Bao P, Yoshida T, Kumakura Y, Honjo H, Sakai M, Sohda M, Fukuchi M, Altan B, Handa T, Ide M, Miyazaki T, Ogata K, Oyama T, Shimizu K, Mogi A, Asao T, Shirabe K, Kuwano H, Kaira K. High expression of carcinoembryonic antigen and telomerase reverse transcriptase in circulating tumor cells is associated with poor clinical response to the immune checkpoint inhibitor nivolumab. Oncol Lett 2018 15:3061-3067 PubMed ID: 29435038 DOI: 10.3892/ol.2017.7671

10721 Sato H, Sakaguchi M, Yamamoto H, Tomida S, Aoe K, Shien K, Yoshioka T, Namba K, Torigoe H, Soh J, Tsukuda K, Tao H, Okabe K, Miyoshi S, Pass HI, Toyooka S. Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma. Oncogenesis 2018 7:11 PubMed ID: 29362358 DOI: 10.1038/s41389-017-0017-3

10768 Kashima Y, Suzuki A, Liu Y, Hosokawa M, Matsunaga H, Shirai M, Arikawa K, Sugano S, Kohno T, Takeyama H, Tsuchihara K, Suzuki Y. Combinatory use of distinct single-cell RNA-seq analytical platforms reveals the heterogeneous transcriptome response. Sci Rep 2018 8:3482 PubMed ID: 29472726 DOI: 10.1038/s41598-018-21161-y

10784 Senju H, Kumagai A, Nakamura Y, Yamaguchi H, Nakatomi K, Fukami S, Shiraishi K, Harada Y, Nakamura M, Okamura H, Tanaka Y, Mukae H. Effect of IL-18 on the Expansion and Phenotype of Human Natural Killer Cells: Application to Cancer Immunotherapy. Int. J. Biol. Sci. 2018 14:331-340 PubMed ID: 29559850 DOI: 10.7150/ijbs.22809

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11201 Cao S, Wang Z, Gao X, He W, Cai Y, Chen H, Xu R. FOXC1 induces cancer stem cell-like properties through upregulation of beta-catenin in NSCLC. J. Exp. Clin. Cancer Res. 2018 PubMed ID: 30189871 DOI: 10.1186/s13046-018-0894-0

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14901 Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis Mol Cancer Res 2018 16(3):554-563 PubMed ID: 29330298 DOI: 10.1158/1541-7786.MCR-17-0393

15838 Hasako S, Terasaka M, Abe N, Uno T, Ohsawa H, Hashimoto A, Fujita R, Tanaka K, Okayama T, Wadhwa R, Miyadera K, Aoyagi Y, Yonekura K, Matsuo K. TAS6417, A Novel EGFR Inhibitor Targeting Exon 20 Insertion Mutations Mol Cancer Ther 2018 17(8):1648-1658 PubMed ID: 29748209 DOI: 10.1158/1535-7163.MCT-17-1206

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15843 Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, Hino H, Kikuchi H, Takano N, Hiramoto M, Tsukahara K, Miyazawa K. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis Int J Oncol 2018 1165-1177 PubMed ID: 29484439 DOI: 10.3892/ijo.2018.4282

10132 Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, Takahashi T. TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Oncogene 2017 36:3740-3748 PubMed ID: 28192407 DOI: 10.1038/onc.2016.524

10280 Seike M, Kim CH, Zou F, Noro R, Chiba M, Ishikawa A, Κunugi S, Kubota K, Gemma A. AXL and GAS6 co-expression in lung adenocarcinoma as a prognostic classifier. Oncol. Rep. 2017 37:3261-3269 PubMed ID: 28440492 DOI: 10.3892/or.2017.5594

10317 Kurimoto R, Ebata T, Iwasawa S, Ishiwata T, Tada Y, Tatsumi K, Takiguchi Y. Pirfenidone may revert the epithelial-to-mesenchymal transition in human lung adenocarcinoma. Oncol Lett 2017 14:944-950 PubMed ID: 28693256 DOI: 10.3892/ol.2017.6188

10530 Niessen S, Dix MM, Barbas S, Potter ZE, Lu S, Brodsky O, Planken S, Behenna D, Almaden C, Gajiwala KS, Ryan K, Ferre R, Lazear MR, Hayward MM, Kath JC, Cravatt BF. Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors. Cell Chem Biol 2017 24:1388-1400.e7 PubMed ID: 28965727 DOI: 10.1016/j.chembiol.2017.08.017

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14432 Sato T, Shiba-Ishii A, Kim Y, Dai T, Husni RE, Hong J, Kano J, Sakashita S, Iijima T, Noguchi M. miR-3941: A novel microRNA that controls IGBP1 expression and is associated with malignant progression of lung adenocarcinoma Cancer Sci 2017 108(3):536-542 PubMed ID: 28012229 DOI: 10.1111/cas.13148

14449 Asaka S, Yoshizawa A, Matsuda K, Yamaguchi A, Yamamoto H, Shiina T, Nakata R, Ogawa K, Zhang M, Honda T. A novel, rapid point-of-care test for lung cancer patients to detect epidermal growth factor receptor gene mutations by using real-time droplet-PCR and fresh liquid cytology specimens Oncol Rep 2017 37(2):1020-1026 PubMed ID: 27922678 DOI: 10.3892/or.2016.5287

14627 Chikaishi Y, Yoneda K, Ohnaga T, Tanaka F. EpCAM-independent capture of circulating tumor cells with a 'universal CTC-chip' Oncol Rep 2017 37(1):77-82 PubMed ID: 27840987 DOI: 10.3892/or.2016.5235

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