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Cell No. : Cell Name
RCB3588 : hPSC-5  update : 2025/03/26
CommentHuman cell line derived from pacreatic cancer. Pancreatic stellate cells.
Comment from the depositor
Terms and conditions1) The availability of the BIOLOGICAL RESOURCE is restricted to a RECIPIENT of a not-for profit organization for a not-for profit research. 2) For use of the BIOLOGICAL RESOURCE by a for-profit organization or by a not-for profit organization for for-profit research, the RECIPIENT must reach agreement on Terms and Conditions of use of it with the DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. 3) Co-authorship must be given to the depositor when the results using the cells are published.
Remarks
approver's address
×
English
Address
Tohoku university hospital

1-1 Seiryo-cho, Aobaka-ku, Sendai Miyagi 980-8574 Japan
Dr.MASAMUNE Atsushi
Fax. +81-22-717-7177
Order Form Order Form(C-0005.pdf)   Approval Form(C-0006.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Masamune, Atsushi
Originator Masamune, Atsushi
Year of deposit 2011
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Female
Tissue pancreas
Disease name pancreas cancer
Classification normal
Lifespan finite
Crisis PDL 50 PDL
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_T769
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM/HamF12 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 2.5 split
SC frequency Subculture : once/5 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma/Acholeplasma (-)
Animal PCR OK
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 5


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Reference
16509  Oshima Y, Sano M, Kajiwara I, Ichimaru Y, Itaya T, Kuramochi T, Hayashi E, Kim J, Kitajima O, Masugi Y, Masamune A, Ijichi H, Ishii Y, Suzuki T.  Midazolam exhibits antitumour and anti-inflammatory effects in a mouse model of pancreatic ductal adenocarcinoma  Br J Anaesth  2022  128(4):679-690  PubMed ID: 35120712   DOI: 10.1016/j.bja.2021.12.042
22431  Kajiwara I, Sano M, Ichimaru Y, Oshima Y, Kitajima O, Hao H, Masamune A, Kim J, Ishii Y, Ijichi H, Suzuki T.  Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer through stimulation of noradrenaline pathway and its antitumor effects  Pain  2020  161(12):2909-2919  PubMed ID: 32694385   DOI: 10.1097/j.pain.0000000000001997

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User's Publication
19848  Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Ishii N, Tsukagoshi M, Watanabe A, Harimoto N, Masamune A, Uojima H, Mizokami M, Ito K, Shirabe K.  Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer  Cancer Sci  2024  Feb 6  PubMed ID: 38321872   DOI: 10.1111/cas.16087
22346  Tsunetoshi Y, Sanada F, Kanemoto Y, Shibata K, Masamune A, Taniyama Y, Yamamoto K, Morishita R.  A Role for Periostin Pathological Variants and Their Interaction with HSP70-1a in Promoting Pancreatic Cancer Progression and Chemoresistance  Int J Mol Sci  2024  25(23):13205  PubMed ID: 39684914   DOI: 10.3390/ijms252313205
19772  Itaya T, Sano M, Kajiwara I, Oshima Y, Kuramochi T, Kim J, Ichimaru Y, Kitajima O, Masamune A, Ijichi H, Ishii Y, Suzuki T.  Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer  Pain  2023  164(7):1545-1554  PubMed ID: 36701124   DOI: 10.1097/j.pain.0000000000002852
22431  Kajiwara I, Sano M, Ichimaru Y, Oshima Y, Kitajima O, Hao H, Masamune A, Kim J, Ishii Y, Ijichi H, Suzuki T.  Duloxetine improves cancer-associated pain in a mouse model of pancreatic cancer through stimulation of noradrenaline pathway and its antitumor effects  Pain  2020  161(12):2909-2919  PubMed ID: 32694385   DOI: 10.1097/j.pain.0000000000001997
6912  Ishii N, Araki K, Yokobori T, Hagiwara K, Gantumur D, Yamanaka T, Handa T, Tsukagoshi M, Igarashi T, Watanabe A, Kubo N, Harimoto N, Masamune A, Umezawa K, Kuwano H, Shirabe K.  Conophylline suppresses pancreatic cancer desmoplasia and cancer-promoting cytokines produced by cancer-associated fibroblasts.  Cancer Sci  2019  110(1):334-344  PubMed ID: 30353606   DOI: 10.1111/cas.13847


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