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Cell No. : Cell Name
RCB3576 : Aska-SS  update : 2023/10/16
CommentHuman cell line derived from synovial sarcoma.
Comment from the depositor
Terms and conditionsIn publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Stem Cells 2010;28:1119-1131) designated by the DEPOSITOR is required.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Naka, Norifumi
Originator Naka, Norifumi
Year of deposit 2011
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 27 years
Tissue subcutaneous tissue of groin
Disease name Synovial sarcoma (Stage 4)
Metastastatic ability Yes
Metastatsd tissue Lung
Classification cancer
Year of origin 2005
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_6C43
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (high glucose, without Sodium pyruvate) + 20% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 2-4 split
SC frequency Subculture : once/1-2 weeks, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
deposit info
lot info
Reference information Reference 5
User's Publication 4

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15489  Yokoo S, Fujiwara T, Yoshida A, Uotani K, Morita T, Kiyono M, Hasei J, Nakata E, Kunisada T, Iwata S, Yonemoto T, Ueda K, Ozaki T.  Liquid Biopsy Targeting Monocarboxylate Transporter 1 on the Surface Membrane of Tumor-Derived Extracellular Vesicles from Synovial Sarcoma  Cancers (Basel)  2021  13(8):1823  PubMed ID: 33920416   DOI: 10.3390/cancers13081823
15501  Yasui H, Imura Y, Outani H, Hamada K, Nakai T, Yamada S, Takenaka S, Sasagawa S, Araki N, Itoh K, Myoui A, Yoshikawa H, Naka N.  Trabectedin is a promising antitumour agent for synovial sarcoma  J Chemother  2016  28(5):417-24  PubMed ID: 27077926   DOI: 10.1080/1120009X.2015.1133013
16270  Toru Wakamatsu, Norifumi Naka, Satoru Sasagawa, Takaaki Tanaka, Satoshi Takenaka, Nobuhito Araki, Takafumi Ueda, Yasuko Nishizawa, Hideki Yoshikawa, Kazuyuki Itoh  Deflection of vascular endothelial growth factor action by SS18-SSX and composite vascular endothelial growth factor- and chemokine (C-X-C motif) receptor 4-targeted therapy in synovial sarcoma  Cancer Sci  2014  105(9):1124-34  PubMed ID: 24975049   DOI: 10.1111/cas.12469
15415  Yasui H, Naka N, Imura Y, Outani H, Kaneko K, Hamada K, Sasagawa S, Araki N, Ueda T, Itoh K, Myoui A, Yoshikawa H.  Tailored therapeutic strategies for synovial sarcoma: receptor tyrosine kinase pathway analyses predict sensitivity to the mTOR inhibitor RAD001  Cancer Lett  2014  347(1):114-22  PubMed ID: 24491407   DOI: 10.1016/j.canlet.2014.01.027
3639  Naka N, Takenaka S, Araki N, Miwa T, Hashimoto N, Yoshioka K, Joyama S, Hamada K, Tsukamoto Y, Tomita Y, Ueda T, Yoshikawa H, Itoh K.  Synovial sarcoma is a stem cell malignancy.  Stem Cells.  2010  28(7):1119-31  PubMed ID: 20518020   DOI: 10.1002/stem.452

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User's Publication
20225  Jayabal P, Zhou F, Lei X, Ma X, Blackman B, Weintraub ST, Houghton PJ, Shiio Y.  NELL2-cdc42 signaling regulates BAF complexes and Ewing sarcoma cell growth.  Cell Rep  2021  36(1):109254  PubMed ID: 34233189   DOI: 10.1016/j.celrep.2021.109254
20274  Su BC, Hung GY, Tu YC, Yeh WC, Lin MC, Chen JY.  Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization.  Mar Drugs  2021  19(2)  PubMed ID: 33562681   DOI: 10.3390/md19020093
16177  Fairchild CK Jr, Floros KV, Jacob S, Coon CM, Puchalapalli M, Hu B, Harada H, Dozmorov MG, Koblinski JE, Smith SC, Domson G, Leverson JD, Souers AJ, Takebe N, Ebi H, Faber AC, Boikos SA.  Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA  Cancers (Basel)  2021  13(10):2310  PubMed ID: 34065859   DOI: 10.3390/cancers13102310
14603  Michel BC, D'Avino AR, Cassel SH, Mashtalir N, McKenzie ZM, McBride MJ, Valencia AM, Zhou Q, Bocker M, Soares LMM, Pan J, Remillard DI, Lareau CA, Zullow HJ, Fortoul N, Gray NS, Bradner JE, Chan HM, Kadoch C.  A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation  Nat Cell Biol  2018  20(12):1410-1420  PubMed ID: 30397315   DOI: 10.1038/s41556-018-0221-1

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