Back Back
Cell No. : Cell Name
RCB3531 : A904L  update : 2021/05/20
CommentHuman cell line derived from lung large cell carcinoma cells.
Comment from the depositor
Terms and conditionsIn publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Int J Cancer 2007;120:1055-1062.) designated by the DEPOSITOR is required.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Hanagiri, Takeshi
Originator Takenoyama, Mitsuhiro
Year of deposit 2010
Animal human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 46 years
Tissue lung
Disease name lung cell carcinoma
Classification cancer
Year of origin 1996
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_U095
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10mM HEPES + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 4-6 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
deposit info
lot info
Reference information Reference 17
User's Publication 1

To topTop
8987  Tetsuro Baba, Takeshi Hanagiri, Mitsuhiro Takenoyama, Hironobu Shiota, Koji Kuroda, Yoshiki Shigematsu, Yoshinobu Ichiki, Hidetaka Uramoto, Tomoko So, Kosei Yasumoto  Identification of a Lung Cancer Antigen Evading CTL Attack Due to Loss of Human Leukocyte Antigen (HLA) Class I Expression  Cancer Sci  2010  101 (10), 2115-20  PubMed ID: 20649604   DOI: 10.1111/j.1349-7006.2010.01659.x
8991  Manabu Yasuda, Takeshi Hanagiri, Yoshiki Shigematsu, Takamitsu Onitsuka, Kouji Kuroda, Tetsurou Baba, Makiko Mizukami, Yoshinobu Ichiki, Hidetaka Uramoto, Mitsuhiro Takenoyama, Kosei Yasumoto  Identification of a Tumour Associated Antigen in Lung Cancer Patients With Asbestos Exposure  Anticancer Res  2010  30 (7), 2631-9  PubMed ID: 20682992  
8999  Hidetaka Uramoto, Hidehiko Shimokawa, Yoshika Nagata, Kenji Ono, Takeshi Hanagiri  EGFR-activating Mutations Are Not Present in Breast Tumors of Japanese Patients  Anticancer Res  2010  30 (10), 4219-22  PubMed ID: 21036744  
8990  Kosei Yasumoto, Takeshi Hanagiri, Mitsuhiro Takenoyama  Lung Cancer-Associated Tumor Antigens and the Present Status of Immunotherapy Against Non-Small-Cell Lung Cancer  Gen Thorac Cardiovasc Surg  2009  57 (9), 449-57  PubMed ID: 19756930   DOI: 10.1007/s11748-008-0433-6
3628  Baba T, Hanagiri T, Ichiki Y, Kuroda K, Shigematsu Y, Mizukami M, Sugaya M, Takenoyama M, Sugio K, Yasumoto K.  Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.  Cancer Sci  2007  98(11):1795-802  PubMed ID: 17725806   DOI: 10.1111/j.1349-7006.2007.00586.x
3637  Sugaya M, Takenoyama M, Shigematsu Y, Baba T, Fukuyama T, Nagata Y, Mizukami M, So T, Ichiki Y, Yasuda M, So T, Hanagiri T, Sugio K, Yasumoto K.  Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung.  Int J Cancer  2007  120(5):1055-62  PubMed ID: 17131342   DOI: 10.1002/ijc.22396
8995  Takashi Fukuyama, Yoshinobu Ichiki, Sousuke Yamada, Yoshiki Shigematsu, Tetsuro Baba, Yoshika Nagata, Makiko Mizukami, Masakazu Sugaya, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  Cytokine Production of Lung Cancer Cell Lines: Correlation Between Their Production and the Inflammatory/Immunological Responses Both in Vivo and in Vitro  Cancer Sci  2007  98 (7), 1048-54  PubMed ID: 17511773   DOI: 10.1111/j.1349-7006.2007.00507.x
9004  Makiko Mizukami, Takeshi Hanagiri, Manabu Yasuda, Koji Kuroda, Yoshiki Shigematsu, Tetsuro Baba, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Tomoko So, Mitsuhiro Takenoyama, Kenji Sugio, Kosei Yasumoto  Antitumor Effect of Antibody Against a SEREX-defined Antigen (UOEH-LC-1) on Lung Cancer Xenotransplanted Into Severe Combined Immunodeficiency Mice  Cancer Res  2007  67 (17), 8351-7  PubMed ID: 17804751   DOI: 10.1158/0008-5472.CAN-06-3889
8988  Takashi Fukuyama, Takeshi Hanagiri, Mitsuhiro Takenoyama, Yoshinobu Ichiki, Makiko Mizukami, Tetsuya So, Masakazu Sugaya, Tomoko So, Kenji Sugio, Kosei Yasumoto  Identification of a New Cancer/Germline Gene, KK-LC-1, Encoding an Antigen Recognized by Autologous CTL Induced on Human Lung Adenocarcinoma  Cancer Res  2006  66 (9), 4922-8  PubMed ID: 16651449   DOI: 10.1158/0008-5472.CAN-05-3840
9000  Manabu Yasuda, Makiko Mizukami, Takeshi Hanagiri, Yoshiki Shigematsu, Takashi Fukuyama, Yoshika Nagata, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Mitsuhiro Takenoyama, Kenji Sugio, Kosei Yasumoto  Antigens Recognized by IgG Derived From Tumor-Infiltrating B Lymphocytes in Human Lung Cancer  Anticancer Res  2006  26 (5A), 3607-11  PubMed ID: 17094490  
7413  Mizukami M, Hanagiri T, Baba T, Fukuyama T, Nagata Y, So T, Ichiki Y, Sugaya M, Yasuda M, Takenoyama M, Sugio K, Yasumoto K.  Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course.  Cancer Sci  2005  96(12):882-8  PubMed ID: 16367908   DOI: 10.1111/j.1349-7006.2005.00119.x
8948  Yoshika Nagata, Takeshi Hanagiri, Mitsuhiro Takenoyama, Takashi Fukuyama, Makiko Mizukami, Tetsuya So, Yoshinobu Ichiki, Masakazu Sugaya, Kenji Sugio, Kosei Yasumoto  Identification of the HLA-Cw*0702-restricted Tumor-Associated Antigen Recognized by a CTL Clone From a Lung Cancer Patient  Clin Cancer Res  2005  11 (14), 5265-72  PubMed ID: 16033845   DOI: 10.1158/1078-0432.CCR-04-2542
8949  Tetsuya So, Mitsuhiro Takenoyama, Makiko Mizukami, Yoshinobu Ichiki, Masakazu Sugaya, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  Haplotype Loss of HLA Class I Antigen as an Escape Mechanism From Immune Attack in Lung Cancer  Cancer Res  2005  65 (13), 5945-52  PubMed ID: 15994973   DOI: 10.1158/0008-5472.CAN-04-3787
8947  Yoshinobu Ichiki, Mitsuhiro Takenoyama, Makiko Mizukami, Tetsuya So, Masakazu Sugaya, Manabu Yasuda, Tomoko So, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  Simultaneous Cellular and Humoral Immune Response Against Mutated p53 in a Patient With Lung Cancer  J Immunol  2004  172 (8), 4844-50  PubMed ID: 15067062   DOI: 10.4049/jimmunol.172.8.4844
9001  Manabu Yasuda, Mitsuhiro Takenoyama, Yuichi Obata, Masakazu Sugaya, Tomoko So, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  Tumor-infiltrating B Lymphocytes as a Potential Source of Identifying Tumor Antigen in Human Lung Cancer  Cancer Res  2002  62 (6), 1751-6  PubMed ID: 11912150  
9003  Satoru Imahayashi, Tomoko So, Masakazu Sugaya, Manabu Yasuda, Ryozo Eifuku, Mitsuhiro Takenoyama, Takeshi Hanagiri, Takashi Yoshimatsu, Tsunehiro Oyama, Kosei Yasumoto  Establishment of an Immortalized T-cell Line From Lung Cancer Tissue: Phenotypic and Functional Analyses  Int J Clin Oncol  2002  7 (1), 38-44  PubMed ID: 11942048   DOI: 10.1007/s101470200004
3636  Takenoyama M, Yoshino I, Eifuku R, So T, Imahayashi S, Sugaya M, Yasuda M, Inoue M, Ichiyoshi Y, Osaki T, Nagashima A, Nomoto K, Yasumoto K.  Successful induction of tumor-specific cytotoxic T lymphocytes from patients with non-small cell lung cancer using CD80-transfected autologous tumor cells.  Jpn J Cancer Res  2001  92(3):309-15  PubMed ID: 11267941   DOI: 10.1111/j.1349-7006.2001.tb01096.x

To topTop
User's Publication
20884  Shindo A, Kusano M, Sakagami H, Amano S, Inomata M, Abe M, Okazawa M, Ooka T.  Comparison of UVC Sensitivity and Dectin-2 Expression Between Malignant and Non-malignant Cells.  In Vivo  2022  36(5):2116-2125  PubMed ID: 36099100   DOI: 10.21873/invivo.12937

Back Back Return Top Page