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Cell No. : Cell Name
RCB3529 : G603L  update : 2023/10/16
CommentHuman cell line derived from lung large cell carcinoma cells.
Comment from the depositor
Terms and conditionsIn publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Cancer Sci, 2005;96:882-8 ) designated by the DEPOSITOR is required.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor HANAGIRI, Takeshi
Originator TAKENOYAMA, Mitsuhiro
Year of deposit 2010
Animal _human < Mammals
Genus Homo
Species sapiens
Race Japanese
Gender Male
Age at sampling 75 years
Tissue lung
Disease name large cell carcinoma
Metastastatic ability Unknown
Classification cancer
Year of origin 2002
Lifespan infinite
Morphology fibroblast-like
Cellosaurus(Expasy) CVCL_U091
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10mM HEPES + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
Reference information Reference 12
User's Publication 0

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8987  Tetsuro Baba, Takeshi Hanagiri, Mitsuhiro Takenoyama, Hironobu Shiota, Koji Kuroda, Yoshiki Shigematsu, Yoshinobu Ichiki, Hidetaka Uramoto, Tomoko So, Kosei Yasumoto  Identification of a Lung Cancer Antigen Evading CTL Attack Due to Loss of Human Leukocyte Antigen (HLA) Class I Expression  Cancer Sci  2010  101 (10), 2115-20  PubMed ID: 20649604   DOI: 10.1111/j.1349-7006.2010.01659.x
8991  Manabu Yasuda, Takeshi Hanagiri, Yoshiki Shigematsu, Takamitsu Onitsuka, Kouji Kuroda, Tetsurou Baba, Makiko Mizukami, Yoshinobu Ichiki, Hidetaka Uramoto, Mitsuhiro Takenoyama, Kosei Yasumoto  Identification of a Tumour Associated Antigen in Lung Cancer Patients With Asbestos Exposure  Anticancer Res  2010  30 (7), 2631-9  PubMed ID: 20682992  
8992  Koji Kuroda, Mitsuhiro Takenoyama, Tetsuro Baba, Yoshiki Shigematsu, Hironobu Shiota, Yoshinobu Ichiki, Manabu Yasuda, Hidetaka Uramoto, Takeshi Hanagiri, Kosei Yasumoto  Identification of Ribosomal Protein L19 as a Novel Tumor Antigen Recognized by Autologous Cytotoxic T Lymphocytes in Lung Adenocarcinoma  Cancer Sci  2010  101 (1), 46-53  PubMed ID: 19799608   DOI: 10.1111/j.1349-7006.2009.01351.x
8999  Hidetaka Uramoto, Hidehiko Shimokawa, Yoshika Nagata, Kenji Ono, Takeshi Hanagiri  EGFR-activating Mutations Are Not Present in Breast Tumors of Japanese Patients  Anticancer Res  2010  30 (10), 4219-22  PubMed ID: 21036744  
8990  Kosei Yasumoto, Takeshi Hanagiri, Mitsuhiro Takenoyama  Lung Cancer-Associated Tumor Antigens and the Present Status of Immunotherapy Against Non-Small-Cell Lung Cancer  Gen Thorac Cardiovasc Surg  2009  57 (9), 449-57  PubMed ID: 19756930   DOI: 10.1007/s11748-008-0433-6
3628  Baba T, Hanagiri T, Ichiki Y, Kuroda K, Shigematsu Y, Mizukami M, Sugaya M, Takenoyama M, Sugio K, Yasumoto K.  Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B.  Cancer Sci  2007  98(11):1795-802  PubMed ID: 17725806   DOI: 10.1111/j.1349-7006.2007.00586.x
3637  Sugaya M, Takenoyama M, Shigematsu Y, Baba T, Fukuyama T, Nagata Y, Mizukami M, So T, Ichiki Y, Yasuda M, So T, Hanagiri T, Sugio K, Yasumoto K.  Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung.  Int J Cancer  2007  120(5):1055-62  PubMed ID: 17131342   DOI: 10.1002/ijc.22396
8995  Takashi Fukuyama, Yoshinobu Ichiki, Sousuke Yamada, Yoshiki Shigematsu, Tetsuro Baba, Yoshika Nagata, Makiko Mizukami, Masakazu Sugaya, Mitsuhiro Takenoyama, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  Cytokine Production of Lung Cancer Cell Lines: Correlation Between Their Production and the Inflammatory/Immunological Responses Both in Vivo and in Vitro  Cancer Sci  2007  98 (7), 1048-54  PubMed ID: 17511773   DOI: 10.1111/j.1349-7006.2007.00507.x
8988  Takashi Fukuyama, Takeshi Hanagiri, Mitsuhiro Takenoyama, Yoshinobu Ichiki, Makiko Mizukami, Tetsuya So, Masakazu Sugaya, Tomoko So, Kenji Sugio, Kosei Yasumoto  Identification of a New Cancer/Germline Gene, KK-LC-1, Encoding an Antigen Recognized by Autologous CTL Induced on Human Lung Adenocarcinoma  Cancer Res  2006  66 (9), 4922-8  PubMed ID: 16651449   DOI: 10.1158/0008-5472.CAN-05-3840
8989  K Sugio, H Uramoto, K Ono, T Oyama, T Hanagiri, M Sugaya, Y Ichiki, T So, S Nakata, M Morita, K Yasumoto  Mutations Within the Tyrosine Kinase Domain of EGFR Gene Specifically Occur in Lung Adenocarcinoma Patients With a Low Exposure of Tobacco Smoking  Br J Cancer  2006  94 (6), 896-903  PubMed ID: 16552419   DOI: 10.1038/sj.bjc.6603040
7413  Mizukami M, Hanagiri T, Baba T, Fukuyama T, Nagata Y, So T, Ichiki Y, Sugaya M, Yasuda M, Takenoyama M, Sugio K, Yasumoto K.  Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course.  Cancer Sci  2005  96(12):882-8  PubMed ID: 16367908   DOI: 10.1111/j.1349-7006.2005.00119.x
8986  Tetsuya So, Mitsuhiro Takenoyama, Yoshinobu Ichiki, Makiko Mizukami, Tomoko So, Takeshi Hanagiri, Kenji Sugio, Kosei Yasumoto  A Different Pattern of Cytotoxic T Lymphocyte Recognition Against Primary and Metastatic Tumor Cells in a Patient With Nonsmall Cell Lung Carcinoma  Cancer  2005  103 (1), 200-8 2005  PubMed ID: 15573370   DOI: 10.1002/cncr.20782

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