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細胞番号 : 細胞名
RCB2979 : HCT116  update : 2024/11/12
細胞特性(Comment:英)Human cell line derived from colon cancer.
細胞特性(日)ヒト大腸癌由来細胞株。
細胞特性(寄託者記述:英)Loss of the DNA mismatch repair gene (hMLH1).
細胞特性(寄託者記述:日)ミスマッチ修復遺伝子(hMLH1)欠損。
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず cellbank.brc@riken.jp までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Shiomi, Tadahiro
寄託日 2009
動物種 _human < Mammals
属名 Homo
種名 sapiens
性別 Male
採取組織 colon
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0291
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 DMEM (low glucose) + 10% FBS
抗生物質 Free
継代方法 0.25% Trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ/アコレプラズマ (-)
動物種PCR OK
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 3件
Reference(日) 0件
利用者成果(英) 142件
利用者成果(日) 0件

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Reference(英)
18268  Katsube T, Mori M, Tsuji H, Shiomi T, Shiomi N, Onoda M.  Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells  J Radiat Res  2011  52(4):415-24  PubMed ID: 21785230   DOI: 10.1269/jrr.10168
5492  Long BH, Willson JK, Brattain DE, Musial S, Brattain MG.  Effects of mitomycin on human colon carcinoma cells.  J Natl Cancer Inst  1984  73(4):787-92  PubMed ID: 6434780  
5491  Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE.  Heterogeneity of malignant cells from a human colonic carcinoma.  Cancer Res  1981  41(5):1751-6  PubMed ID: 7214343  

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Reference(日)

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利用者成果(英)
21655  Ichisaka Y, Yano S, Nishimura K, Niwa T, Shimizu H.  Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt.  Biomed Res  2024  45(2):57-66  PubMed ID: 38556263   DOI: 10.2220/biomedres.45.57
21662  Kato K, Yasui H, Sato-Akaba H, Emoto MC, Fujii HG, Kmiec MM, Kuppusamy P, Mizuno Y, Kuge Y, Nagane M, Yamashita T, Inanami O.  Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor.  Free Radic Biol Med  2024  218:57-67  PubMed ID: 38574976   DOI: 10.1016/j.freeradbiomed.2024.03.028
21679  Morotomi-Yano K, Hayami S, Yano KI.  Adhesion States Greatly Affect Cellular Susceptibility to Graphene Oxide: Therapeutic Implications for Cancer Metastasis.  Int J Mol Sci  2024  25(3)  PubMed ID: 38339205   DOI: 10.3390/ijms25031927
21709  Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T.  Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.  J Gastroenterol  2024    PubMed ID: 38695904   DOI: 10.1007/s00535-024-02104-z
21968  Yoshinaga N, Numata K.  Poly(A) Tail Length of Messenger RNA Regulates Translational Efficiency of the Mitochondria-Targeting Delivery System.  ACS Biomater Sci Eng  2024  Sep 4  PubMed ID: 39231264   DOI: 10.1021/acsbiomaterials.4c01169
22112  Nakano Y, Masuda T, Sakamoto T, Tanaka N, Tobo T, Hashimoto M, Tatsumi T, Saito H, Takahashi J, Koike K, Abe T, Ando Y, Ozato Y, Hosoda K, Hirose K, Higuchi S, Ikehara T, Hisamatsu Y, Toshima T, Yonemura Y, Ogino T, Uemura M, Eguchi H, Doki Y, Mimori K.  SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expression.  Int J Oncol  2024  65(6)  PubMed ID: 39450547   DOI: 10.3892/ijo.2024.5701
22115  Hashimoto N, Ito S, Harazono A, Tsuchida A, Mouri Y, Yamamoto A, Okajima T, Ohmi Y, Furukawa K, Kudo Y, Kawasaki N, Furukawa K.  Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance.  iScience  2024  27(11):111139  PubMed ID: 39507251   DOI: 10.1016/j.isci.2024.111139
22245  Soeta T, Sugisawa N, Yamamura A, Tanaka N, Imoto H, Tsuchiya T, Aizawa T, Okamoto K, Kawamura M, Saijo F, Mizuma M, Ohnuma S, Kamei T, Unno M.  MRTX1719, an MTA-cooperative PRMT5 Inhibitor, Induces Cell Cycle Arrest and Synergizes With Oxaliplatin and Gemcitabine for Enhanced Anticancer Effects.  Anticancer Res  2024  44(12):5231-5240  PubMed ID: 39626906   DOI: 10.21873/anticanres.17351
17806  Shoji A, Arai Y, Asakawa R, Saito T, Kuramochi K, Yajima A.  Synthesis and structure-activity relationship of violaceoid D, a cytotoxic alkylated phenol isolated from Aspergillus violaceofuscus Gasperini  Biosci Biotechnol Biochem  2023  87(4):363-370  PubMed ID: 36592963   DOI: 10.1093/bbb/zbac212
19597  Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A.  The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis  Sci Rep  2023  13(1):14405  PubMed ID: 37658135   DOI: 10.1038/s41598-023-41492-9
19720  Hirose S, Waku T, Tani M, Masuda H, Endo K, Ashitani S, Aketa I, Kitano H, Nakada S, Wada A, Hatanaka A, Osawa T, Soga T, Kobayashi A.  NRF3 activates mTORC1 arginine-dependently for cancer cell viability  iScience  2023  26(2):106045  PubMed ID: 36818298   DOI: 10.1016/j.isci.2023.106045
19740  Takiguchi K, Shimizu H, Shoda K, Shiraishi K, Furuya S, Hosomura N, Akaike H, Kawaguchi Y, Amemiya H, Kawaida H, Mochizuki K, Kondo T, Ichikawa D.  The Expression and Role of NADPH Oxidase 2 in Colon Cancer  Anticancer Res  2023  43(6):2601-2608  PubMed ID: 37247898   DOI: 10.21873/anticanres.16427
19762  RICO RAMADHAN, ENIH ROSAMAH, IRAWAN WIJAYA KUSUMA, HARLINDA KUSPRADINI, YHIYA AMEN, YONG-UNG KIM, KUNIYOSHI SHIMIZU, ENOS TANGKE ARUNG  Cytotoxicity effect of prenylated flavonoids from Stingless Bee (Wallacetrigona insica) propolis in some cancer cell lines  Herba Polonica  2023  69:9-13    DOI: 10.5604/01.3001.0053.6135
19826  Nashimoto Y, Shishido S, Onuma K, Ino K, Inoue M, Shiku H.  Oxygen metabolism analysis of a single organoid for non-invasive discrimination of cancer subpopulations with different growth capabilities  Front Bioeng Biotechnol  2023  11:1184325  PubMed ID: 37274161   DOI: 10.3389/fbioe.2023.1184325
19960  Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.  An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types  BMC Genomics  2023  24(1):735  PubMed ID: 38049715   DOI: 10.1186/s12864-023-09841-0
19975  Aiba T, Hijiya N, Akagi T, Tsukamoto Y, Hirashita Y, Kinoshita K, Uchida T, Nakada C, Kurogi S, Ueda Y, Shiroshita H, Shiraishi N, Murakami K, Inomata M, Moriyama M.  Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis  Pathobiology  2023  Oct 5  PubMed ID: 37797604   DOI: 10.1159/000533877
21078  Tsuji D, Nakayama A, Yamamoto R, Nagano S, Taniguchi T, Sato R, Karanjit S, Muguruma N, Takayama T, Itoh K, Namba K.  1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes.  Commun Chem  2023  6(1):37  PubMed ID: 36813913   DOI: 10.1038/s42004-023-00838-0
21273  Tomihari A, Kiyota M, Matsuura A, Itakura E.  Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins.  Sci Rep  2023  13(1):4680  PubMed ID: 36977730   DOI: 10.1038/s41598-023-31104-x
21285  Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E.  Prohaptoglobin is a possible prognostic biomarker for colorectal cancer.  Biochem Biophys Res Commun  2023  672:72-80  PubMed ID: 37343317   DOI: 10.1016/j.bbrc.2023.06.017
21307  Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E.  Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer.  Ann Surg Oncol  2023    PubMed ID: 37407874   DOI: 10.1245/s10434-023-13779-8
21320  Takeuchi H, Koga M, Doi K, Sakurai H.  PP2A and its adapter protein IER5 induce the DNA-binding ability and target gene expression of E2F1 via dephosphorylation at serine 375.  Biochim Biophys Acta Gene Regul Mech  2023  1866(3):194960  PubMed ID: 37467925   DOI: 10.1016/j.bbagrm.2023.194960
21327  Simanurak O, Pekthong D, Somran J, Wangteeraprasert A, Srikummool M, Kaewpaeng N, Parhira S, Srisawang P.  Enhanced apoptosis of HCT116 colon cancer cells treated with extracts from Calotropis gigantea stem bark by starvation.  Heliyon  2023  9(7):e18013  PubMed ID: 37483695   DOI: 10.1016/j.heliyon.2023.e18013
21364  Yamanaka S, Furihata H, Yanagihara Y, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S, Kosako H, Tanokura M, Miyakawa T, Imai Y, Shibata N, Sawasaki T.  Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation.  Nat Commun  2023  14(1):4683  PubMed ID: 37596276   DOI: 10.1038/s41467-023-40385-9
21403  Yamamoto T, Uehara R.  Cell shape instability during cytokinesis in tetraploid HCT116 cells.  Biochem Biophys Res Commun  2023  678:39-44  PubMed ID: 37619310   DOI: 10.1016/j.bbrc.2023.08.038
21510  Iwaki M, Kanemoto Y, Sawada T, Nojiri K, Kurokawa T, Tsutsumi R, Nagasawa K, Kato S.  Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells.  PLoS One  2023  18(12):e0295288  PubMed ID: 38091304   DOI: 10.1371/journal.pone.0295288
21526  Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H.  Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells.  Eur J Pharmacol  2023  960:176156  PubMed ID: 38059445   DOI: 10.1016/j.ejphar.2023.176156
22228  Yoshizawa K, Matsura A, Shimada M, Ishida-Ishihara S, Sato F, Yamamoto T, Yaguchi K, Kawamoto E, Kuroda T, Matsuo K, Tamaoki N, Sakai R, Shimada Y, Mishra M, Uehara R.  Tetraploidy-linked sensitization to CENP-E inhibition in human cells  Mol Oncol  2023  17(6):1148-1166  PubMed ID: 36688680   DOI: 10.1002/1878-0261.13379
17551  Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform  Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform  Metabolites  2022  12(7):646  PubMed ID: 35888770   DOI: 10.3390/metabo12070646
17610  Yasudome R, Seki N, Asai S, Goto Y, Kita Y, Hozaka Y, Wada M, Tanabe K, Idichi T, Mori S, Ohtsuka T.  Molecular Pathogenesis of Colorectal Cancer: Impact of Oncogenic Targets Regulated by Tumor Suppressive miR-139-3p  Int J Mol Sci  2022  23(19):11616  PubMed ID: 36232922   DOI: 10.3390/ijms231911616
17660  Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O  The Inhibitory Effects of Anti-ERC/Mesothelin Antibody 22A31 on Colorectal Adenocarcinoma Cells, within a Mouse Xenograft Model  Cancers (Basel)  2022  14(9):2198  PubMed ID: 35565327   DOI: 10.3390/cancers14092198
17793  Kosuke Kimura, Takeshi Yasunaga, Takumi Makikawa, Daisuke Takahashi, Kazunobu Toshima  Efficient Strategy for the Preparation of Chemical Probes of Biologically Active Glycosides Using a Boron-Mediated Aglycon Delivery (BMAD) Method  Bulletin of the Chemical Society of Japan  2022  95:1075-1082    DOI: 10.1246/bcsj.20220076
17798  Chen P, Yang W, Hong T, Miyazaki T, Dirisala A, Kataoka K, Cabral H.  Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC  Biomaterials  2022  288:121748  PubMed ID: 36038419   DOI: 10.1016/j.biomaterials.2022.121748
16354  Koike M, Yutoku Y, Koike A.  Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites  FEBS Open Bio  2022  Jan 9  PubMed ID: 35000298   DOI: 10.1002/2211-5463.13363
16356  Monzen S, Ueno T, Chiba M, Morino Y, Mariya Y, Wojcik A, Lundholm L.  Dose-dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high-dose-rate ionising radiation  Mol Clin Oncol  2022  16(1):19  PubMed ID: 34881039   DOI: 10.3892/mco.2021.2452
20605  Ciftci H, Sever B, Ocak F, Bayrak N, Yıldız M, Yıldırım H, DeMirci H, Tateishi H, Otsuka M, Fujita M, TuYuN AF.  In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.  Molecules  2022  27(3)  PubMed ID: 35163957   DOI: 10.3390/molecules27030693
20703  Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M.  Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.  Pharmaceuticals (Basel)  2022  15(4)  PubMed ID: 35455423   DOI: 10.3390/ph15040426
20726  Hino SI, Inenaga K, Miyazaki T, Tanaka-Mizota C.  Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling.  Nutr Cancer  2022  1-8  PubMed ID: 35658755   DOI: 10.1080/01635581.2022.2084122
20733  Masumoto K, Aihara Y, Miyagawa Kuroishi M, Maeda N, Sakai Y, Oka Y, Takahashi Y, Oda K, Yanagida M.  Highly sensitive and non-disruptive detection of residual undifferentiated cells by measuring miRNAs in culture supernatant.  Sci Rep  2022  12(1):10351  PubMed ID: 35725891   DOI: 10.1038/s41598-022-14273-z
20744  Asakawa R, Fuchiyama K, Ishii Y, Hosaka K, Kobayashi A, Shimazaki K, Nagasawa J, Tsuchida S, Ushida K, Matsubayashi M, Furuyama Y, Ohgane K, Kuramochi K.  Synthesis and Cytotoxic Activities of 8- and 6-Demethyleucalyptins.  Biosci Biotechnol Biochem  2022    PubMed ID: 35776954   DOI: 10.1093/bbb/zbac105
16724  Kenji Sugawara, Daichi Kanki, Ryuichi Watanabe, Ryoji Matsushima, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Akihiro Ninomiya, Shigeru Okada, Shigeki Matsunaga  Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge  Tetrahedron  2022  119:132859    DOI: 10.1016/j.tet.2022.132859
16725  Hasegawa T, Ito M, Hasegawa S, Teranishi M, Takeda K, Negishi S, Nishiwaki H, Takeda JI, LeBaron TW, Ohno K.  Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response  Int J Mol Sci  2022  23(5):2888  PubMed ID: 35270030   DOI: 10.3390/ijms23052888
20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20846  Takahashi M, Sukowati EW, Nomura S, Kato A, Mizuseki K, Watanabe Y, Mukai H.  Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours.  J Drug Target  2022  1-12  PubMed ID: 36097977   DOI: 10.1080/1061186X.2022.2122477
20853  Uranbileg B, Kurano M, Kano K, Sakai E, Arita J, Hasegawa K, Nishikawa T, Ishihara S, Yamashita H, Seto Y, Ikeda H, Aoki J, Yatomi Y.  Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids.  Clin Transl Med  2022  12(9):e1056  PubMed ID: 36125914   DOI: 10.1002/ctm2.1056
20955  Morotomi-Yano K, Hiromoto Y, Higaki T, Yano KI.  Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ.  Sci Rep  2022  12(1):20627  PubMed ID: 36450898   DOI: 10.1038/s41598-022-24883-2
20968  Ciftci H, Sever B, Bayrak N, Yıldız M, Yıldırım H, Tateishi H, Otsuka M, Fujita M, TuYuN AF.  In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights.  Pharmaceuticals (Basel)  2022  15(10)  PubMed ID: 36297378   DOI: 10.3390/ph15101266
21129  Ciftci H, Sever B, Kaya N, Bayrak N, Yıldız M, Yıldırım H, Tateishi H, Otsuka M, Fujita M, TuYuN AF.  Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects.  Molecules  2022  28(1)  PubMed ID: 36615273   DOI: 10.3390/molecules28010077
22229  Gombodorj N, Yokobori T, Mutsuki N, Erkhem-Ochir B, Okami H, Asao T, Saeki H, Shirabe K, Yamanouchi D.  Effects of Ultrafine Single-Nanometer Oxygen Bubbles on Radiation Sensitivity in a Tumor-Bearing Mouse Model  Int J Mol Sci  2022  23(12):6838  PubMed ID: 35743281   DOI: 10.3390/ijms23126838
19517  Nomura TK, Heishima K, Sugito N, Sugawara R, Ueda H, Yukihiro A, Honda R.  Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains  Cell Chem Biol  2021  28(11):1581-1589.e6  PubMed ID: 33964212   DOI: 10.1016/j.chembiol.2021.04.013
13604  Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H.  Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder  Biochim Biophys Acta Mol Basis Dis  2021  1867(6):166106  PubMed ID: 33631320   DOI: 10.1016/j.bbadis.2021.166106
20083  Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K.  Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.  Sci Rep  2021  11(1):6163  PubMed ID: 33731797   DOI: 10.1038/s41598-021-85603-w
14869  Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K.  miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells  Sci Rep  2021  11(1):13502  PubMed ID: 34226586   DOI: 10.1038/s41598-021-92879-5
15080  Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K.  Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells  Lab Invest  2021  101(8):1036-1047  PubMed ID: 33911189   DOI: 10.1038/s41374-021-00590-w
20272  Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.  Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.  Sci Rep  2021  11(1):13471  PubMed ID: 34188113   DOI: 10.1038/s41598-021-92860-2
20311  Ashizawa N, Shimizu H, Shoda K, Furuya S, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Sudo M, Inoue S, Kono H, Katsurahara K, Shiozaki A, Ichikawa D.  NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells.  Int J Oncol  2021  59(2)  PubMed ID: 34278462   DOI: 10.3892/ijo.2021.5243
20372  Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, Ortigoza-Escobar JD, Hanada K.  Intellectual disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution.  J Biol Chem  2021  101338  PubMed ID: 34688657   DOI: 10.1016/j.jbc.2021.101338
15709  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.  Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis  J Clin Invest   2021  131(17):e139933  PubMed ID: 34623325   DOI: 10.1172/JCI139933
15870  Sudo H, Kubo A.  The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol  Int J Mol Sci  2021  22(17):9397  PubMed ID: 34502304   DOI: 10.3390/ijms22179397
16051  Maruoka M, Zhang P, Mori H, Imanishi E, Packwood DM, Harada H, Kosako H, Suzuki J.  Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane  Mol Cell  2021  81(7):1397-1410.e9  PubMed ID: 33725486   DOI: 10.1016/j.molcel.2021.02.025
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12130  Sanada S, Suzuki T, Nagata A, Hashidume T, Yoshikawa Y, Miyoshi N.  Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice.  Sci Rep  2020    PubMed ID: 32296105   DOI: 10.1038/s41598-020-63627-y
12136  Choodej, Khanitha Pudhom  Cycloartane triterpenoids from the leaves of Euphorbia neriifolia  Phytochemistry Letters  2020      DOI: 10.1016/j.phytol.2019.10.005
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