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Cell No. : Cell Name
RCB2979 : HCT116  update : 2022/09/08
CommentHuman cell line derived from colon cancer. Loss of the DNA mismatch repair gene (hMLH1).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Shiomi, Tadahiro
Year of deposit 2009
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Tissue colon
Classification cancer
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0291
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 101


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Reference
5492  Long BH, Willson JK, Brattain DE, Musial S, Brattain MG.  Effects of mitomycin on human colon carcinoma cells.  J Natl Cancer Inst  1984  73(4):787-92  PubMed ID: 6434780  
5491  Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE.  Heterogeneity of malignant cells from a human colonic carcinoma.  Cancer Res  1981  41(5):1751-6  PubMed ID: 7214343  

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User's Publication
16354  Koike M, Yutoku Y, Koike A.  Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites  FEBS Open Bio  2022  Jan 9  PubMed ID: 35000298   DOI: 10.1002/2211-5463.13363
16356  Monzen S, Ueno T, Chiba M, Morino Y, Mariya Y, Wojcik A, Lundholm L.  Dose-dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high-dose-rate ionising radiation  Mol Clin Oncol  2022  16(1):19  PubMed ID: 34881039   DOI: 10.3892/mco.2021.2452
20605  Ciftci H, Sever B, Ocak F, Bayrak N, Yıldız M, Yıldırım H, DeMirci H, Tateishi H, Otsuka M, Fujita M, TuYuN AF.  In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment.  Molecules  2022  27(3)  PubMed ID: 35163957   DOI: 10.3390/molecules27030693
20703  Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M.  Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity.  Pharmaceuticals (Basel)  2022  15(4)  PubMed ID: 35455423   DOI: 10.3390/ph15040426
20726  Hino SI, Inenaga K, Miyazaki T, Tanaka-Mizota C.  Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling.  Nutr Cancer  2022  1-8  PubMed ID: 35658755   DOI: 10.1080/01635581.2022.2084122
20733  Masumoto K, Aihara Y, Miyagawa Kuroishi M, Maeda N, Sakai Y, Oka Y, Takahashi Y, Oda K, Yanagida M.  Highly sensitive and non-disruptive detection of residual undifferentiated cells by measuring miRNAs in culture supernatant.  Sci Rep  2022  12(1):10351  PubMed ID: 35725891   DOI: 10.1038/s41598-022-14273-z
20744  Asakawa R, Fuchiyama K, Ishii Y, Hosaka K, Kobayashi A, Shimazaki K, Nagasawa J, Tsuchida S, Ushida K, Matsubayashi M, Furuyama Y, Ohgane K, Kuramochi K.  Synthesis and Cytotoxic Activities of 8- and 6-Demethyleucalyptins.  Biosci Biotechnol Biochem  2022    PubMed ID: 35776954   DOI: 10.1093/bbb/zbac105
16724  Kenji Sugawara, Daichi Kanki, Ryuichi Watanabe, Ryoji Matsushima, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Akihiro Ninomiya, Shigeru Okada, Shigeki Matsunaga  Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge  Tetrahedron  2022  119:132859    DOI: 10.1016/j.tet.2022.132859
20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20846  Takahashi M, Sukowati EW, Nomura S, Kato A, Mizuseki K, Watanabe Y, Mukai H.  Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours.  J Drug Target  2022  1-12  PubMed ID: 36097977   DOI: 10.1080/1061186X.2022.2122477
20853  Uranbileg B, Kurano M, Kano K, Sakai E, Arita J, Hasegawa K, Nishikawa T, Ishihara S, Yamashita H, Seto Y, Ikeda H, Aoki J, Yatomi Y.  Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids.  Clin Transl Med  2022  12(9):e1056  PubMed ID: 36125914   DOI: 10.1002/ctm2.1056
13604  Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H.  Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder  Biochim Biophys Acta Mol Basis Dis  2021  1867(6):166106  PubMed ID: 33631320   DOI: 10.1016/j.bbadis.2021.166106
20083  Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K.  Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.  Sci Rep  2021  11(1):6163  PubMed ID: 33731797   DOI: 10.1038/s41598-021-85603-w
15080  Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K.  Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells  Lab Invest  2021  101(8):1036-1047  PubMed ID: 33911189   DOI: 10.1038/s41374-021-00590-w
20272  Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.  Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.  Sci Rep  2021  11(1):13471  PubMed ID: 34188113   DOI: 10.1038/s41598-021-92860-2
20311  Ashizawa N, Shimizu H, Shoda K, Furuya S, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Sudo M, Inoue S, Kono H, Katsurahara K, Shiozaki A, Ichikawa D.  NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells.  Int J Oncol  2021  59(2)  PubMed ID: 34278462   DOI: 10.3892/ijo.2021.5243
20372  Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, Ortigoza-Escobar JD, Hanada K.  Intellectual disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution.  J Biol Chem  2021  101338  PubMed ID: 34688657   DOI: 10.1016/j.jbc.2021.101338
15709  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.  Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis  J Clin Invest   2021  131(17):e139933  PubMed ID: 34623325   DOI: 10.1172/JCI139933
15870  Sudo H, Kubo A.  The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol  Int J Mol Sci  2021  22(17):9397  PubMed ID: 34502304   DOI: 10.3390/ijms22179397
16051  Maruoka M, Zhang P, Mori H, Imanishi E, Packwood DM, Harada H, Kosako H, Suzuki J.  Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane  Mol Cell  2021  81(7):1397-1410.e9  PubMed ID: 33725486   DOI: 10.1016/j.molcel.2021.02.025
16067  Lazarova D, Semkova S, Zlateva G, Tatsuya H, Aoki I, Bakalova R.  Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging  Anal Chem  2021  93(5):2828-2837  PubMed ID: 33508934   DOI: 10.1021/acs.analchem.0c04116
16123  Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M.  Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation  Front Oncol9  2021  11:70593  PubMed ID: 34595111   DOI: 10.3389/fonc.2021.705939
16282  Hozaka Y, Kita Y, Yasudome R, Tanaka T, Wada M, Idichi T, Tanabe K, Asai S, Moriya S, Toda H, Mori S, Kurahara H, Ohtsuka T, Seki N.  RNA-Sequencing Based microRNA Expression Signature of Colorectal Cancer: The Impact of Oncogenic Targets Regulated by miR-490-3p  Int J Mol Sci   2021  22(18):9876  PubMed ID: 34576039   DOI: 10.3390/ijms22189876
6918  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.  Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.  Cell Chem Biol  2020  27(2):186-196  PubMed ID: 31813846   DOI: 10.1016/j.chembiol.2019.11.010
9166  Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada, Kana Kato, Nan Jia, Satoru Hashimoto, Yuko Kotani, Yuka Miyoshi, Miyako Tanaka, Akira Sobue, Norisato Mitsutake, Takayoshi Suganami, Akio Masuda, Kinji Ohno, Shinichiro Nakada, Tomoji Mashimo, Koji Yamanaka, Martijn S Luijsterburg, Tomoo Ogi   Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair  Cell  2020  180 (6), 1228-1244  PubMed ID: 32142649   DOI: 10.1016/j.cell.2020.02.010
9913  Satoshi Inoue, Takumi Tsunoda, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Ira Pastan, Kunio Kasugai, Kenji Kasai, Hiroshi Ikeda, Shingo Inaguma  Diffuse Mesothelin Expression Leads to Worse Prognosis Through Enhanced Cellular Proliferation in Colorectal Cancer  Oncol Lett  2020  19(3):1741-1750  PubMed ID: 32194667   DOI: 10.3892/ol.2020.11290
11905  Igarashi H, Taniguchi H, Nosho K, Ishigami K, Koide H, Mitsuhashi K, Okita K, Takemasa I, Imai K, Nakase H.  PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.  Clin Transl Oncol  2020  22(7):1126-1137  PubMed ID: 31741141   DOI: 10.1007/s12094-019-02239-z
11910  Ujiie D, Okayama H, Saito K, Ashizawa M, Thar Min AK, Endo E, Kase K, Yamada L, Kikuchi T, Hanayama H, Fujita S, Sakamoto W, Endo H, Saito M, Mimura K, Saze Z, Momma T, Ohki S, Kono K.  KRT17 as a prognostic biomarker for stage II colorectal cancer.  Carcinogenesis  2020  41(5):591-599.  PubMed ID: 31754689   DOI: 10.1093/carcin/bgz192
12035  Kitao A, Kawamoto S, Kurata K, Hayakawa I, Yamasaki T, Matsuoka H, Sumi Y, Kakeji Y, Kamesaki T, Minami H.  Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte membrane-bound IgG and may cause immune-related anemia.  Int. J. Hematol.  2020    PubMed ID: 31997080   DOI: 10.1007/s12185-020-02831-y
12130  Sanada S, Suzuki T, Nagata A, Hashidume T, Yoshikawa Y, Miyoshi N.  Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice.  Sci Rep  2020    PubMed ID: 32296105   DOI: 10.1038/s41598-020-63627-y
12136  Choodej, Khanitha Pudhom  Cycloartane triterpenoids from the leaves of Euphorbia neriifolia  Phytochemistry Letters  2020      DOI: 10.1016/j.phytol.2019.10.005
12150  Amira Mira, Mohamed A. Sabry, Kuniyoshi Shimizu & Fatma M. Abdel Bar  A new pimarane-type diterpene obtained by biotransformation inhibits human HCT-116 colorectal carcinoma through inhibition of LTA4H activity  Original Research  2020      DOI: 10.1007/s00044-020-02520-9
13059  Ratsada P, Hijiya N, Hidano S, Tsukamoto Y, Nakada C, Uchida T, Kobayashi T, Moriyama M.  DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32505357   DOI: 10.1016/j.bbrc.2020.05.140
13210  Wada Y, Morine Y, Imura S, Ikemoto T, Saito Y, Takasu C, Yamada S, Shimada M.  HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis.  World J Surg Oncol  2020    PubMed ID: 32895059   DOI: 10.1186/s12957-020-02012-5
13220  Miyano K, Okamoto S, Yamauchi A, Kajikawa M, Kiyohara T, Taura M, Kawai C, Kuribayashi F.  Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration.  Free Radic Res  2020    PubMed ID: 32924676   DOI: 10.1080/10715762.2020.1823383
13390  Murakami H, Tamura N, Enomoto Y, Shimasaki K, Kurosawa K, Hanada K.  Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT.  PLoS One  2020    PubMed ID: 33347465   DOI: 10.1371/journal.pone.0243980
13454  Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh  Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro  Personalized Medicine Universe  2020      DOI: 10.46459/pmu.2020001
13502  Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K.  GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer  Cancer Sci  2020  111(2):343-355  PubMed ID: 31758608   DOI: 10.1111/cas.14248
13505  Oka S, Kuniba R, Tsuboi N, Tsuchida S, Ushida K, Tomoshige S, Kuramochi K.  Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum  Biosci Biotechnol Biochem  2020  84(1):31-36  PubMed ID: 31794330   DOI: 10.1080/09168451.2019.1662279
13902  Mito A, Kumazawa-Inoue K, Kojima-Aikawa K.  ZG16p, an Animal Homologue of Plant β-Prism Fold Lectins: Purification Methods of Natural and Recombinant ZG16p and Inhibition Assay of Cancer Cell Growth Using ZG16p  Methods Mol Biol  2020  2132:339-347  PubMed ID: 32306341   DOI: 10.1007/978-1-0716-0430-4_33
14364  Kohzaki M, Ootsuyama A, Sun L, Moritake T, Okazaki R.  Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment  Int J Cancer  2020  146(11):3098-3113  PubMed ID: 31495919   DOI: 10.1002/ijc.32670
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14875  Mizuno M, Mori K, Tsuchiya K, Takaki T, Misawa T, Demizu Y, Shibanuma M, Fukuhara K.  Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin  ACS Omega  2020  5(36):23164-23174  PubMed ID: 32954167   DOI: 10.1021/acsomega.0c02936
11388  Kitada K, Pu F, Toi M.  Occurrence of senescence-escaping cells in doxorubicin-induced senescence is enhanced by PD0332991, a cyclin-dependent kinase 4/6 inhibitor, in colon cancer HCT116 cells.  Oncol Lett  2019    PubMed ID: 30655877   DOI: 10.3892/ol.2018.9657
11359  Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K.  CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis.  Anticancer Res.  2019    PubMed ID: 30591445   DOI: 10.21873/anticanres.13084
11408  Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K.  Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing.  Cancer Prev Res (Phila)  2019    PubMed ID: 30700439   DOI: 10.1158/1940-6207.CAPR-18-0288
11517  Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y.  Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.  Cancer Chemother. Pharmacol.  2019    PubMed ID: 30972456   DOI: 10.1007/s00280-019-03837-y
11724  Othman DIA, Selim KB, El-Sayed MA, Tantawy AS, Amen Y, Shimizu K, Okauchi T, Kitamura M.  Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.  Bioorg. Med. Chem.  2019    PubMed ID: 31416740   DOI: 10.1016/j.bmc.2019.07.042
11725  Kawasaki Y, Miyamoto M, Oda T, Matsumura K, Negishi L, Nakato R, Suda S, Yokota N, Shirahige K, Akiyama T.  The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis.  EMBO Rep.  2019    PubMed ID: 31353791   DOI: 10.15252/embr.201847052
11835  Yokoyama Y, Sakatani T, Wada R, Ishino K, Kudo M, Koizumi M, Yamada T, Yoshida H, Naito Z.  In vitro and in vivo studies on the association of long non‑coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5‑fluorouracil in rectal cancer.  Int. J. Oncol.  2019    PubMed ID: 31638183   DOI: 10.3892/ijo.2019.4895
11851  Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.  Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.  Sci Rep  2019    PubMed ID: 31611630   DOI: 10.1038/s41598-019-51462-9
11864  Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K.  Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1.  J. Org. Chem.  2019    PubMed ID: 31642324   DOI: 10.1021/acs.joc.9b02304
12405  Kouyama Y, Masuda T, Fujii A, Ogawa Y, Sato K, Tobo T, Wakiyama H, Yoshikawa Y, Noda M, Tsuruda Y, Kuroda Y, Eguchi H, Ishida F, Kudo SE, Mimori K.  Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer  Cancer Sci   2019  110(10):3132-3144  PubMed ID: 31390121   DOI: 10.1111/cas.14163
12420  Aoki T, Nishita M, Sonoda J, Ikeda T, Kakeji Y, Minami Y.  Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules  Cancer Sci  2019  110(4):1306-1316  PubMed ID: 30742741   DOI: 10.1111/cas.13970
12421  Koike M, Yutoku Y, Koike A.  Feline XLF accumulates at DNA damage sites in a Ku-dependent manner  FEBS Open Bio  2019  9(6):1052-1062  PubMed ID: 31115163   DOI: 10.1002/2211-5463.12589
12422  Miyagi A, Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents  Biol Pharm Bull  2019  42(4):638-644.  PubMed ID: 30930422   DOI: 10.1248/bpb.b18-00855
12423  Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W.  Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1  Gastroenterology  2019  156(3):662-675.e7  PubMed ID: 30342037   DOI: 10.1053/j.gastro.2018.10.030
12424  Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T.  Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect  J Pharmacol Sci  2019  140(3):291-294  PubMed ID: 31377017   DOI: 10.1016/j.jphs.2019.05.009
12517  Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K.  Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi)  Nat Prod Res  2019  33(2):189-195  PubMed ID: 29457741   DOI: 10.1080/14786419.2018.1440229
14360  Ashizawa M, Okayama H, Ishigame T, Thar Min AK, Saito K, Ujiie D, Murakami Y, Kikuchi T, Nakayama Y, Noda M, Tada T, Endo H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K.  miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1  Mol Cancer Res  2019  17(6):1403-1413  PubMed ID: 30872332   DOI: 10.1158/1541-7786.MCR-18-0831
9501  Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M.  Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival.  Nat Commun  2018  9:1561  PubMed ID: 29674746   DOI: 10.1038/s41467-018-03899-1
10580  Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K.  Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites.  Glycobiology  2018  28:21-31  PubMed ID: 29069492   DOI: 10.1093/glycob/cwx088
10606  Kanno E, Kawasaki O, Takahashi K, Takano K, Endo T.  DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.  Exp. Cell Res.  2018  362:111-120  PubMed ID: 29129563   DOI: 10.1016/j.yexcr.2017.11.008
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323   DOI: 10.1186/s12885-017-3958-1
10751  Noguchi A, Adachi S, Yokota N, Hatta T, Natsume T, Kawahara H.  ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest.  Biol Open  2018  7:  PubMed ID: 29449217   DOI: 10.1242/bio.031575
10757  Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S.  H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers.  Nat. Med.  2018  24:497-504  PubMed ID: 29457796   DOI: 10.1038/nm.4493
10847  Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K.  Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer.  PLoS ONE  2018  13:e0194785  PubMed ID: 29746493   DOI: 10.1371/journal.pone.0194785
11009    Evidence suggesting sphingosine 1-phosphate may be actively generated, degraded and transported to extracellular spaces with increased S1P2 and S1P3 expressions in colon cancer  Clinical Colorectal Cancer  2018  17, e171-e182  PubMed ID: 29223361   DOI: 10.1016/j.clcc.2017.11.004
11087  Thar Min AK, Okayama H, Saito M, Ashizawa M, Aoto K, Nakajima T, Saito K, Hayase S, Sakamoto W, Tada T, Hanayama H, Saze Z, Momma T, Ohki S, Sato Y, Motoyama S, Mimura K, Kono K.  Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma.  Cancer Med  2018    PubMed ID: 29855157   DOI: 10.1002/cam4.1564
4422  Enos Tangke Arung, Rudianto Amirta, Qinchang Zhu, Yhiya Amen, Kuniyoshi Shimizu  Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines  Journal of the Indian Academy of Wood Science  2018  5, 115–119    DOI: 10.1007/s13196-018-0215-4
4195  Ishigaki Y, Sato K.  Effects of Microchannel Shape and Ultrasonic Mixing on Microfluidic Padlock Probe Rolling Circle Amplification (RCA) Reactions.  Micromachines (Basel)  2018    PubMed ID: 30424205   DOI: 10.3390/mi9060272
4196  Wada F, Koga H, Akiba J, Niizeki T, Iwamoto H, Ikezono Y, Nakamura T, Abe M, Masuda A, Sakaue T, Tanaka T, Kakuma T, Yano H, Torimura T.  High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine.  Cancer Sci.  2018    PubMed ID: 29981246   DOI: 10.1111/cas.13728
4344  Li HK, Hasegawa S, Nakajima NI, Morokoshi Y, Minegishi K, Nagatsu K.  Targeted cancer cell ablation in mice by an α-particle-emitting astatine-211-labeled antibody against major histocompatibility complex class I chain-related protein A and B.  Biochem. Biophys. Res. Commun.  2018    PubMed ID: 30409432   DOI: 10.1016/j.bbrc.2018.10.157
4476  Bardales JA, Wieser E, Kawaji H, Murakawa Y, Darzacq X.  Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers.  Genes (Basel)  2018  9(6)  PubMed ID: 29882899   DOI: 10.3390/genes9060270
14526  Yamada NO, Wenduerma, Matsuda S, Senda T.  Validation and application of a novel APC antibody in western blotting, immunoprecipitation, and immunohistochemistry  Med Mol Morphol  2018  51(4):227-236  PubMed ID: 29923125   DOI: 10.1007/s00795-018-0196-9
14901  Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K.  Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis  Mol Cancer Res  2018  16(3):554-563  PubMed ID: 29330298   DOI: 10.1158/1541-7786.MCR-17-0393
14906  Noda M, Okayama H, Tachibana K, Sakamoto W, Saito K, Thar Min AK, Ashizawa M, Nakajima T, Aoto K, Momma T, Katakura K, Ohki S, Kono K.  Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis  Clin Cancer Res  2018  24(18):4468-4481  PubMed ID: 29844132   DOI: 10.1158/1078-0432.CCR-17-3533
9847  Koike M, Yutoku Y, Koike A.  Cloning, localization and focus formation at DNA damage sites of canine XRCC4.  J. Vet. Med. Sci.  2017  78:1865-1871  PubMed ID: 27644316   DOI: 10.1292/jvms.16-0381
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
10296  Gombodorj N, Yokobori T, Yoshiyama S, Kawabata-Iwakawa R, Rokudai S, Horikoshi I, Nishiyama M, Nakano T.  Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer.  Anticancer Res.  2017  37:2425-2436  PubMed ID: 28476810   DOI: 10.21873/anticanres.11582
10498  Inaguma S, Lasota J, Felisiak-Golabek A, Kowalik A, Wang Z, Zieba S, Kalisz J, Ikeda H, Miettinen M.  Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.  J Pathol Clin Res  2017  3:268-278  PubMed ID: 29085667   DOI: 10.1002/cjp2.81
10520  Koike M, Yutoku Y, Koike A.  Cloning of canine Ku80 and its localization and accumulation at DNA damage sites.  FEBS Open Bio  2017  7:1854-1863  PubMed ID: 29226073   DOI: 10.1002/2211-5463.12311
10535  Ohashi W, Yamamine N, Imura J, Hattori Y.  SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex.  Biochem. Biophys. Res. Commun.  2017  493:1342-1348  PubMed ID: 28970068   DOI: 10.1016/j.bbrc.2017.09.161
4194  Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T.  A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform.  Lab Chip  2017    PubMed ID: 29184959   DOI: 10.1039/c7lc00952f
10028  Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori  Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells  Int J Oncol  2017  50(3):787-797.  PubMed ID: 28197625   DOI: 10.3892/ijo.2017.3859
14055  Morishita S, Suzuki T, Niwa Y, Dohmae N, Simizu S.  Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines  Oncol Lett  2017  14(2):2537-2544  PubMed ID: 28781692   DOI: 10.3892/ol.2017.6465
14621  Koike M, Yutoku Y, Koike A.  Cloning, localization and focus formation at DNA damage sites of canine Ku70  J Vet Med Sci  2017  79(3):554-561  PubMed ID: 28163277   DOI: 10.1292/jvms.16-0649
14642  Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T.  Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway  Cancer Sci  2017  108(1):108-115  PubMed ID: 27761963   DOI: 10.1111/cas.13106
9637  Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M.  A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells.  Exp. Cell Res.  2016  343:177-189  PubMed ID: 27032575   DOI: 10.1016/j.yexcr.2016.03.023
10913    Clinical potential of DAC-70 sol  Integr Mol Med  2016  3: 645-648    DOI: 10.15761/IMM.1000216
12896  Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S.  The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction  Elife  2016  5:e18357  PubMed ID: 27528193   DOI: 10.7554/eLife.18357
13474  Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS.  α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15  Sci Rep  2016  6:25895  PubMed ID: 27181033   DOI: 10.1038/srep25895
13991  Tanaka G, Inoue K, Shimizu T, Akimoto K, Kubota K.  Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells  Cancer Med  2016  5(9):2544-57  PubMed ID: 27485632   DOI: 10.1002/cam4.844
14105  Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M.  SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer  Cancer Sci  2016  107(5):619-28  PubMed ID: 26892864   DOI: 10.1111/cas.12909
7305  Yamada K, Maishi N, Akiyama K, Towfik Alam M, Ohga N, Kawamoto T, Shindoh M, Takahashi N, Kamiyama T, Hida Y, Taketomi A, Hida K.  CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property.  Int. J. Cancer  2015  137:2825-36  PubMed ID: 26100110   DOI: 10.1002/ijc.29655
7560  Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K  Standard WT1 Expression Using Immunohistochemistry.  J Mol Biomark Diagn  2015  7:266    DOI: 10.4172/2155-9929.1000266
14459  Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H.  MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells  PLoS One  2015  10(5):e0127119  PubMed ID: 25970424   DOI: 10.1371/journal.pone.0127119
15139  Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura K, Baba H, Ohmuraya M.  SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer  Mol Cancer Res  2015  13(7):1130-8  PubMed ID: 25804623   DOI: 10.1158/1541-7786.MCR-14-0581
15210  Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T.  XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency  J Allergy Clin Immunol  2015  136(4):1007-17  PubMed ID: 26255102   DOI: 10.1016/j.jaci.2015.06.007
4397  Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ.  Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer.  Tumour Biol  2011  32(4):729-35  PubMed ID: 21523445   DOI: 10.1007/s13277-011-0174-5



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