CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2979 : HCT116]

18268 Katsube T, Mori M, Tsuji H, Shiomi T, Shiomi N, Onoda M. Differences in sensitivity to DNA-damaging Agents between XRCC4- and Artemis-deficient human cells J Radiat Res 2011 52(4):415-24 PubMed ID: 21785230 DOI: 10.1269/jrr.10168

5492 Long BH, Willson JK, Brattain DE, Musial S, Brattain MG. Effects of mitomycin on human colon carcinoma cells. J Natl Cancer Inst 1984 73(4):787-92 PubMed ID: 6434780

5491 Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE. Heterogeneity of malignant cells from a human colonic carcinoma. Cancer Res 1981 41(5):1751-6 PubMed ID: 7214343

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22452 Iwasa Y, Miyata S, Tomita T, Yokota N, Miyauchi M, Mori R, Matsushita S, Suzuki R, Saeki Y, Kawahara H. TanGIBLE: A selective probe for evaluating hydrophobicity-exposed defective proteins in live cells. J Cell Biol 2025 224(3) PubMed ID: 39812643 DOI: 10.1083/jcb.202109010

22506 Ichisaka Y, Takei C, Naito K, Higa M, Yano S, Niwa T, Shimizu H. The Role of Indoxyl Sulfate in Exacerbating Colorectal Cancer During Chronic Kidney Disease Progression: Insights into the Akt/β-Catenin/c-Myc and AhR/c-Myc Pathways in HCT-116 Colorectal Cancer Cells Toxins (Basel) 2025 17(1):17. PubMed ID: 39852970 DOI: 10.3390/toxins17010017

22553 Kaewpaeng N, Wongwan S, Pansooksan K, Chailom C, Chaisupasakul P, Pekthong D, Nuengchamnong N, Jiang ZH, Bai LP, Srisawang P, Parhira S. HPLC-MS standardization and validation methods for determination of calactin content in dichloromethane fraction of Calotropis gigantea (L.) Dryand. (Niu jiao gua) stem bark and its application in prediction of anticancer activities. Heliyon 2025 11(3):e41963 PubMed ID: 39916826 DOI: 10.1016/j.heliyon.2025.e41963

22606 Nakada T, Koga M, Takeuchi H, Doi K, Sugiyama H, Sakurai H. PP2A adapter protein IER5 induces dephosphorylation and degradation of MDM2, thereby stabilizing p53. Cell Signal 2025 131:111739 PubMed ID: 40081547 DOI: 10.1016/j.cellsig.2025.111739

21655 Ichisaka Y, Yano S, Nishimura K, Niwa T, Shimizu H. Indoxyl sulfate contributes to colorectal cancer cell proliferation and increased EGFR expression by activating AhR and Akt. Biomed Res 2024 45(2):57-66 PubMed ID: 38556263 DOI: 10.2220/biomedres.45.57

21662 Kato K, Yasui H, Sato-Akaba H, Emoto MC, Fujii HG, Kmiec MM, Kuppusamy P, Mizuno Y, Kuge Y, Nagane M, Yamashita T, Inanami O. Feasibility study of multimodal imaging for redox status and glucose metabolism in tumor. Free Radic Biol Med 2024 218:57-67 PubMed ID: 38574976 DOI: 10.1016/j.freeradbiomed.2024.03.028

21679 Morotomi-Yano K, Hayami S, Yano KI. Adhesion States Greatly Affect Cellular Susceptibility to Graphene Oxide: Therapeutic Implications for Cancer Metastasis. Int J Mol Sci 2024 25(3) PubMed ID: 38339205 DOI: 10.3390/ijms25031927

21709 Imazu N, Torisu T, Yokote A, Umeno J, Kawasaki K, Fujioka S, Matsuno Y, Nagasue T, Kawatoko S, Moriyama T, Nitahata T, Uchida Y, Aihara S, Taniguchi Y, Oda Y, Kitazono T. Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine. J Gastroenterol 2024 PubMed ID: 38695904 DOI: 10.1007/s00535-024-02104-z

21968 Yoshinaga N, Numata K. Poly(A) Tail Length of Messenger RNA Regulates Translational Efficiency of the Mitochondria-Targeting Delivery System. ACS Biomater Sci Eng 2024 Sep 4 PubMed ID: 39231264 DOI: 10.1021/acsbiomaterials.4c01169

22112 Nakano Y, Masuda T, Sakamoto T, Tanaka N, Tobo T, Hashimoto M, Tatsumi T, Saito H, Takahashi J, Koike K, Abe T, Ando Y, Ozato Y, Hosoda K, Hirose K, Higuchi S, Ikehara T, Hisamatsu Y, Toshima T, Yonemura Y, Ogino T, Uemura M, Eguchi H, Doki Y, Mimori K. SHARPIN is a novel gene of colorectal cancer that promotes tumor growth potentially via inhibition of p53 expression. Int J Oncol 2024 65(6) PubMed ID: 39450547 DOI: 10.3892/ijo.2024.5701

22115 Hashimoto N, Ito S, Harazono A, Tsuchida A, Mouri Y, Yamamoto A, Okajima T, Ohmi Y, Furukawa K, Kudo Y, Kawasaki N, Furukawa K. Bidirectional signals generated by Siglec-7 and its crucial ligand tri-sialylated T to escape of cancer cells from immune surveillance. iScience 2024 27(11):111139 PubMed ID: 39507251 DOI: 10.1016/j.isci.2024.111139

22245 Soeta T, Sugisawa N, Yamamura A, Tanaka N, Imoto H, Tsuchiya T, Aizawa T, Okamoto K, Kawamura M, Saijo F, Mizuma M, Ohnuma S, Kamei T, Unno M. MRTX1719, an MTA-cooperative PRMT5 Inhibitor, Induces Cell Cycle Arrest and Synergizes With Oxaliplatin and Gemcitabine for Enhanced Anticancer Effects. Anticancer Res 2024 44(12):5231-5240 PubMed ID: 39626906 DOI: 10.21873/anticanres.17351

22379 Liu Z, Koseki Y, Suzuki R, Dao ATN, Kasai H. Sustained Drug Release from Dual-Responsive Hydrogels for Local Cancer Chemo-Photothermal Therapy Macromol Biosci 2024 e2400413 PubMed ID: 39565793 DOI: 10.1002/mabi.202400413

22935 Kanoda R, Nakajima S, Okayama H, Kaneta A, Chida S, Matsumoto T, Saito K, Kikuchi T, Maruyama Y, Suzuki H, Mimura K, Saito M, Hanayama H, Sakamoto W, Momma T, Saze Z, Kono K. Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer. Sci Rep 2024 15(1):19234 PubMed ID: 40451897 DOI: 10.1038/s41598-025-03924-6

17806 Shoji A, Arai Y, Asakawa R, Saito T, Kuramochi K, Yajima A. Synthesis and structure-activity relationship of violaceoid D, a cytotoxic alkylated phenol isolated from Aspergillus violaceofuscus Gasperini Biosci Biotechnol Biochem 2023 87(4):363-370 PubMed ID: 36592963 DOI: 10.1093/bbb/zbac212

19597 Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A. The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis Sci Rep 2023 13(1):14405 PubMed ID: 37658135 DOI: 10.1038/s41598-023-41492-9

19720 Hirose S, Waku T, Tani M, Masuda H, Endo K, Ashitani S, Aketa I, Kitano H, Nakada S, Wada A, Hatanaka A, Osawa T, Soga T, Kobayashi A. NRF3 activates mTORC1 arginine-dependently for cancer cell viability iScience 2023 26(2):106045 PubMed ID: 36818298 DOI: 10.1016/j.isci.2023.106045

19740 Takiguchi K, Shimizu H, Shoda K, Shiraishi K, Furuya S, Hosomura N, Akaike H, Kawaguchi Y, Amemiya H, Kawaida H, Mochizuki K, Kondo T, Ichikawa D. The Expression and Role of NADPH Oxidase 2 in Colon Cancer Anticancer Res 2023 43(6):2601-2608 PubMed ID: 37247898 DOI: 10.21873/anticanres.16427

19762 RICO RAMADHAN, ENIH ROSAMAH, IRAWAN WIJAYA KUSUMA, HARLINDA KUSPRADINI, YHIYA AMEN, YONG-UNG KIM, KUNIYOSHI SHIMIZU, ENOS TANGKE ARUNG Cytotoxicity effect of prenylated flavonoids from Stingless Bee (Wallacetrigona insica) propolis in some cancer cell lines Herba Polonica 2023 69:9-13 DOI: 10.5604/01.3001.0053.6135

19826 Nashimoto Y, Shishido S, Onuma K, Ino K, Inoue M, Shiku H. Oxygen metabolism analysis of a single organoid for non-invasive discrimination of cancer subpopulations with different growth capabilities Front Bioeng Biotechnol 2023 11:1184325 PubMed ID: 37274161 DOI: 10.3389/fbioe.2023.1184325

19960 Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H. An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types BMC Genomics 2023 24(1):735 PubMed ID: 38049715 DOI: 10.1186/s12864-023-09841-0

19975 Aiba T, Hijiya N, Akagi T, Tsukamoto Y, Hirashita Y, Kinoshita K, Uchida T, Nakada C, Kurogi S, Ueda Y, Shiroshita H, Shiraishi N, Murakami K, Inomata M, Moriyama M. Overexpression of VSNL1 enhances cell proliferation in colorectal carcinogenesis Pathobiology 2023 Oct 5 PubMed ID: 37797604 DOI: 10.1159/000533877

21078 Tsuji D, Nakayama A, Yamamoto R, Nagano S, Taniguchi T, Sato R, Karanjit S, Muguruma N, Takayama T, Itoh K, Namba K. 1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes. Commun Chem 2023 6(1):37 PubMed ID: 36813913 DOI: 10.1038/s42004-023-00838-0

21273 Tomihari A, Kiyota M, Matsuura A, Itakura E. Alpha 2-macroglobulin acts as a clearance factor in the lysosomal degradation of extracellular misfolded proteins. Sci Rep 2023 13(1):4680 PubMed ID: 36977730 DOI: 10.1038/s41598-023-31104-x

21285 Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E. Prohaptoglobin is a possible prognostic biomarker for colorectal cancer. Biochem Biophys Res Commun 2023 672:72-80 PubMed ID: 37343317 DOI: 10.1016/j.bbrc.2023.06.017

21307 Sumiyoshi S, Shiozaki A, Kosuga T, Simizu H, Kudo M, Kiuchi J, Arita T, Konishi H, Komatsu S, Kuriu Y, Kubota T, Fujiwara H, Morinaga Y, Konishi E, Otsuji E. Functional Analysis and Clinical Importance of ATP1A1 in Colon Cancer. Ann Surg Oncol 2023 PubMed ID: 37407874 DOI: 10.1245/s10434-023-13779-8

21320 Takeuchi H, Koga M, Doi K, Sakurai H. PP2A and its adapter protein IER5 induce the DNA-binding ability and target gene expression of E2F1 via dephosphorylation at serine 375. Biochim Biophys Acta Gene Regul Mech 2023 1866(3):194960 PubMed ID: 37467925 DOI: 10.1016/j.bbagrm.2023.194960

21327 Simanurak O, Pekthong D, Somran J, Wangteeraprasert A, Srikummool M, Kaewpaeng N, Parhira S, Srisawang P. Enhanced apoptosis of HCT116 colon cancer cells treated with extracts from Calotropis gigantea stem bark by starvation. Heliyon 2023 9(7):e18013 PubMed ID: 37483695 DOI: 10.1016/j.heliyon.2023.e18013

21364 Yamanaka S, Furihata H, Yanagihara Y, Taya A, Nagasaka T, Usui M, Nagaoka K, Shoya Y, Nishino K, Yoshida S, Kosako H, Tanokura M, Miyakawa T, Imai Y, Shibata N, Sawasaki T. Lenalidomide derivatives and proteolysis-targeting chimeras for controlling neosubstrate degradation. Nat Commun 2023 14(1):4683 PubMed ID: 37596276 DOI: 10.1038/s41467-023-40385-9

21403 Yamamoto T, Uehara R. Cell shape instability during cytokinesis in tetraploid HCT116 cells. Biochem Biophys Res Commun 2023 678:39-44 PubMed ID: 37619310 DOI: 10.1016/j.bbrc.2023.08.038

21510 Iwaki M, Kanemoto Y, Sawada T, Nojiri K, Kurokawa T, Tsutsumi R, Nagasawa K, Kato S. Differential gene regulation by a synthetic vitamin D receptor ligand and active vitamin D in human cells. PLoS One 2023 18(12):e0295288 PubMed ID: 38091304 DOI: 10.1371/journal.pone.0295288

21526 Pan Y, Suzuki T, Sakai K, Hirano Y, Ikeda H, Hattori A, Dohmae N, Nishio K, Kakeya H. Bisabosqual A: A novel asparagine synthetase inhibitor suppressing the proliferation and migration of human non-small cell lung cancer A549 cells. Eur J Pharmacol 2023 960:176156 PubMed ID: 38059445 DOI: 10.1016/j.ejphar.2023.176156

22228 Yoshizawa K, Matsura A, Shimada M, Ishida-Ishihara S, Sato F, Yamamoto T, Yaguchi K, Kawamoto E, Kuroda T, Matsuo K, Tamaoki N, Sakai R, Shimada Y, Mishra M, Uehara R. Tetraploidy-linked sensitization to CENP-E inhibition in human cells Mol Oncol 2023 17(6):1148-1166 PubMed ID: 36688680 DOI: 10.1002/1878-0261.13379

17551 Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform Isotope Calculation Gadgets: A Series of Software for Isotope-Tracing Experiments in Garuda Platform Metabolites 2022 12(7):646 PubMed ID: 35888770 DOI: 10.3390/metabo12070646

17610 Yasudome R, Seki N, Asai S, Goto Y, Kita Y, Hozaka Y, Wada M, Tanabe K, Idichi T, Mori S, Ohtsuka T. Molecular Pathogenesis of Colorectal Cancer: Impact of Oncogenic Targets Regulated by Tumor Suppressive miR-139-3p Int J Mol Sci 2022 23(19):11616 PubMed ID: 36232922 DOI: 10.3390/ijms231911616

17660 Taniguchi G, Kajino K, Momose S, Saeki H, Yue L, Ohtsuji N, Abe M, Shibuya T, Orimo A, Nagahara A, Watanabe S, Hino O The Inhibitory Effects of Anti-ERC/Mesothelin Antibody 22A31 on Colorectal Adenocarcinoma Cells, within a Mouse Xenograft Model Cancers (Basel) 2022 14(9):2198 PubMed ID: 35565327 DOI: 10.3390/cancers14092198

17793 Kosuke Kimura, Takeshi Yasunaga, Takumi Makikawa, Daisuke Takahashi, Kazunobu Toshima Efficient Strategy for the Preparation of Chemical Probes of Biologically Active Glycosides Using a Boron-Mediated Aglycon Delivery (BMAD) Method Bulletin of the Chemical Society of Japan 2022 95:1075-1082 DOI: 10.1246/bcsj.20220076

17798 Chen P, Yang W, Hong T, Miyazaki T, Dirisala A, Kataoka K, Cabral H. Nanocarriers escaping from hyperacidified endo/lysosomes in cancer cells allow tumor-targeted intracellular delivery of antibodies to therapeutically inhibit c-MYC Biomaterials 2022 288:121748 PubMed ID: 36038419 DOI: 10.1016/j.biomaterials.2022.121748

16354 Koike M, Yutoku Y, Koike A. Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites FEBS Open Bio 2022 Jan 9 PubMed ID: 35000298 DOI: 10.1002/2211-5463.13363

16356 Monzen S, Ueno T, Chiba M, Morino Y, Mariya Y, Wojcik A, Lundholm L. Dose-dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high-dose-rate ionising radiation Mol Clin Oncol 2022 16(1):19 PubMed ID: 34881039 DOI: 10.3892/mco.2021.2452

20605 Ciftci H, Sever B, Ocak F, Bayrak N, Yıldız M, Yıldırım H, DeMirci H, Tateishi H, Otsuka M, Fujita M, TuYuN AF. In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment. Molecules 2022 27(3) PubMed ID: 35163957 DOI: 10.3390/molecules27030693

20703 Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M. Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity. Pharmaceuticals (Basel) 2022 15(4) PubMed ID: 35455423 DOI: 10.3390/ph15040426

20726 Hino SI, Inenaga K, Miyazaki T, Tanaka-Mizota C. Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling. Nutr Cancer 2022 1-8 PubMed ID: 35658755 DOI: 10.1080/01635581.2022.2084122

20733 Masumoto K, Aihara Y, Miyagawa Kuroishi M, Maeda N, Sakai Y, Oka Y, Takahashi Y, Oda K, Yanagida M. Highly sensitive and non-disruptive detection of residual undifferentiated cells by measuring miRNAs in culture supernatant. Sci Rep 2022 12(1):10351 PubMed ID: 35725891 DOI: 10.1038/s41598-022-14273-z

20744 Asakawa R, Fuchiyama K, Ishii Y, Hosaka K, Kobayashi A, Shimazaki K, Nagasawa J, Tsuchida S, Ushida K, Matsubayashi M, Furuyama Y, Ohgane K, Kuramochi K. Synthesis and Cytotoxic Activities of 8- and 6-Demethyleucalyptins. Biosci Biotechnol Biochem 2022 PubMed ID: 35776954 DOI: 10.1093/bbb/zbac105

16724 Kenji Sugawara, Daichi Kanki, Ryuichi Watanabe, Ryoji Matsushima, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Akihiro Ninomiya, Shigeru Okada, Shigeki Matsunaga Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge Tetrahedron 2022 119:132859 DOI: 10.1016/j.tet.2022.132859

16725 Hasegawa T, Ito M, Hasegawa S, Teranishi M, Takeda K, Negishi S, Nishiwaki H, Takeda JI, LeBaron TW, Ohno K. Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response Int J Mol Sci 2022 23(5):2888 PubMed ID: 35270030 DOI: 10.3390/ijms23052888

20774 Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M. Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun 2022 13(1):4063 PubMed ID: 35831322 DOI: 10.1038/s41467-022-31690-w

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20846 Takahashi M, Sukowati EW, Nomura S, Kato A, Mizuseki K, Watanabe Y, Mukai H. Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours. J Drug Target 2022 1-12 PubMed ID: 36097977 DOI: 10.1080/1061186X.2022.2122477

20853 Uranbileg B, Kurano M, Kano K, Sakai E, Arita J, Hasegawa K, Nishikawa T, Ishihara S, Yamashita H, Seto Y, Ikeda H, Aoki J, Yatomi Y. Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids. Clin Transl Med 2022 12(9):e1056 PubMed ID: 36125914 DOI: 10.1002/ctm2.1056

20955 Morotomi-Yano K, Hiromoto Y, Higaki T, Yano KI. Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ. Sci Rep 2022 12(1):20627 PubMed ID: 36450898 DOI: 10.1038/s41598-022-24883-2

20968 Ciftci H, Sever B, Bayrak N, Yıldız M, Yıldırım H, Tateishi H, Otsuka M, Fujita M, TuYuN AF. In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights. Pharmaceuticals (Basel) 2022 15(10) PubMed ID: 36297378 DOI: 10.3390/ph15101266

21129 Ciftci H, Sever B, Kaya N, Bayrak N, Yıldız M, Yıldırım H, Tateishi H, Otsuka M, Fujita M, TuYuN AF. Studies on 1,4-Quinone Derivatives Exhibiting Anti-Leukemic Activity along with Anti-Colorectal and Anti-Breast Cancer Effects. Molecules 2022 28(1) PubMed ID: 36615273 DOI: 10.3390/molecules28010077

22229 Gombodorj N, Yokobori T, Mutsuki N, Erkhem-Ochir B, Okami H, Asao T, Saeki H, Shirabe K, Yamanouchi D. Effects of Ultrafine Single-Nanometer Oxygen Bubbles on Radiation Sensitivity in a Tumor-Bearing Mouse Model Int J Mol Sci 2022 23(12):6838 PubMed ID: 35743281 DOI: 10.3390/ijms23126838

19517 Nomura TK, Heishima K, Sugito N, Sugawara R, Ueda H, Yukihiro A, Honda R. Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains Cell Chem Biol 2021 28(11):1581-1589.e6 PubMed ID: 33964212 DOI: 10.1016/j.chembiol.2021.04.013

13604 Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H. Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder Biochim Biophys Acta Mol Basis Dis 2021 1867(6):166106 PubMed ID: 33631320 DOI: 10.1016/j.bbadis.2021.166106

20083 Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K. Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues. Sci Rep 2021 11(1):6163 PubMed ID: 33731797 DOI: 10.1038/s41598-021-85603-w

14869 Torii C, Maishi N, Kawamoto T, Morimoto M, Akiyama K, Yoshioka Y, Minami T, Tsumita T, Alam MT, Ochiya T, Hida Y, Hida K. miRNA-1246 in extracellular vesicles secreted from metastatic tumor induces drug resistance in tumor endothelial cells Sci Rep 2021 11(1):13502 PubMed ID: 34226586 DOI: 10.1038/s41598-021-92879-5

15080 Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K. Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells Lab Invest 2021 101(8):1036-1047 PubMed ID: 33911189 DOI: 10.1038/s41374-021-00590-w

20272 Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R. Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA. Sci Rep 2021 11(1):13471 PubMed ID: 34188113 DOI: 10.1038/s41598-021-92860-2

20311 Ashizawa N, Shimizu H, Shoda K, Furuya S, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Sudo M, Inoue S, Kono H, Katsurahara K, Shiozaki A, Ichikawa D. NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells. Int J Oncol 2021 59(2) PubMed ID: 34278462 DOI: 10.3892/ijo.2021.5243

20372 Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, Ortigoza-Escobar JD, Hanada K. Intellectual disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution. J Biol Chem 2021 101338 PubMed ID: 34688657 DOI: 10.1016/j.jbc.2021.101338

15709 Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y. Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis J Clin Invest 2021 131(17):e139933 PubMed ID: 34623325 DOI: 10.1172/JCI139933

15870 Sudo H, Kubo A. The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol Int J Mol Sci 2021 22(17):9397 PubMed ID: 34502304 DOI: 10.3390/ijms22179397

16051 Maruoka M, Zhang P, Mori H, Imanishi E, Packwood DM, Harada H, Kosako H, Suzuki J. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane Mol Cell 2021 81(7):1397-1410.e9 PubMed ID: 33725486 DOI: 10.1016/j.molcel.2021.02.025

16067 Lazarova D, Semkova S, Zlateva G, Tatsuya H, Aoki I, Bakalova R. Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging Anal Chem 2021 93(5):2828-2837 PubMed ID: 33508934 DOI: 10.1021/acs.analchem.0c04116

16123 Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M. Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation Front Oncol9 2021 11:70593 PubMed ID: 34595111 DOI: 10.3389/fonc.2021.705939

16282 Hozaka Y, Kita Y, Yasudome R, Tanaka T, Wada M, Idichi T, Tanabe K, Asai S, Moriya S, Toda H, Mori S, Kurahara H, Ohtsuka T, Seki N. RNA-Sequencing Based microRNA Expression Signature of Colorectal Cancer: The Impact of Oncogenic Targets Regulated by miR-490-3p Int J Mol Sci 2021 22(18):9876 PubMed ID: 34576039 DOI: 10.3390/ijms22189876

18207 Shigematsu N, Kawashiri T, Kobayashi D, Shimizu S, Mine K, Hiromoto S, Uchida M, Egashira N, Shimazoe T. Neuroprotective effect of alogliptin on oxaliplatin-induced peripheral neuropathy in vivo and in vitro Sci Rep 2020 10(1):6734 PubMed ID: 32317735 DOI: 10.1038/s41598-020-62738-w

19423 Kajihara D, Hon CC, Abdullah AN, Wosniak J Jr, Moretti AIS, Poloni JF, Bonatto D, Hashimoto K, Carninci P, Laurindo FRM. Analysis of splice variants of the human protein disulfide isomerase (P4HB) gene BMC Genomics 2020 21(1):766. PubMed ID: 33148170 DOI: 10.1186/s12864-020-07164-y

6918 Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol 2020 27(2):186-196 PubMed ID: 31813846 DOI: 10.1016/j.chembiol.2019.11.010

9166 Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada, Kana Kato, Nan Jia, Satoru Hashimoto, Yuko Kotani, Yuka Miyoshi, Miyako Tanaka, Akira Sobue, Norisato Mitsutake, Takayoshi Suganami, Akio Masuda, Kinji Ohno, Shinichiro Nakada, Tomoji Mashimo, Koji Yamanaka, Martijn S Luijsterburg, Tomoo Ogi Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Cell 2020 180 (6), 1228-1244 PubMed ID: 32142649 DOI: 10.1016/j.cell.2020.02.010

9913 Satoshi Inoue, Takumi Tsunoda, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Ira Pastan, Kunio Kasugai, Kenji Kasai, Hiroshi Ikeda, Shingo Inaguma Diffuse Mesothelin Expression Leads to Worse Prognosis Through Enhanced Cellular Proliferation in Colorectal Cancer Oncol Lett 2020 19(3):1741-1750 PubMed ID: 32194667 DOI: 10.3892/ol.2020.11290

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