CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2979 : HCT116]

5492 Long BH, Willson JK, Brattain DE, Musial S, Brattain MG. Effects of mitomycin on human colon carcinoma cells. J Natl Cancer Inst 1984 73(4):787-92 PubMed ID: 6434780

5491 Brattain MG, Fine WD, Khaled FM, Thompson J, Brattain DE. Heterogeneity of malignant cells from a human colonic carcinoma. Cancer Res 1981 41(5):1751-6 PubMed ID: 7214343

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21078 Tsuji D, Nakayama A, Yamamoto R, Nagano S, Taniguchi T, Sato R, Karanjit S, Muguruma N, Takayama T, Itoh K, Namba K. 1,3a,6a-Triazapentalene derivatives as photo-induced cytotoxic small fluorescent dyes. Commun Chem 2023 6(1):37 PubMed ID: 36813913 DOI: 10.1038/s42004-023-00838-0

16354 Koike M, Yutoku Y, Koike A. Feline XRCC4 undergoes rapid Ku-dependent recruitment to DNA damage sites FEBS Open Bio 2022 Jan 9 PubMed ID: 35000298 DOI: 10.1002/2211-5463.13363

16356 Monzen S, Ueno T, Chiba M, Morino Y, Mariya Y, Wojcik A, Lundholm L. Dose-dependent expression of extracellular microRNAs in HCT116 colorectal cancer cells exposed to high-dose-rate ionising radiation Mol Clin Oncol 2022 16(1):19 PubMed ID: 34881039 DOI: 10.3892/mco.2021.2452

20605 Ciftci H, Sever B, Ocak F, Bayrak N, Yıldız M, Yıldırım H, DeMirci H, Tateishi H, Otsuka M, Fujita M, TuYuN AF. In Vitro and In Silico Study of Analogs of Plant Product Plastoquinone to Be Effective in Colorectal Cancer Treatment. Molecules 2022 27(3) PubMed ID: 35163957 DOI: 10.3390/molecules27030693

20703 Ali TFS, Ciftci HI, Radwan MO, Roshdy E, Shawky AM, Abourehab MAS, Tateishi H, Otsuka M, Fujita M. Discovery of Azaindolin-2-One as a Dual Inhibitor of GSK3β and Tau Aggregation with Potential Neuroprotective Activity. Pharmaceuticals (Basel) 2022 15(4) PubMed ID: 35455423 DOI: 10.3390/ph15040426

20726 Hino SI, Inenaga K, Miyazaki T, Tanaka-Mizota C. Suppression of HCT116 Human Colon Cancer Cell Motility by Polymethoxyflavones is Associated with Inhibition of Wnt/β-Catenin Signaling. Nutr Cancer 2022 1-8 PubMed ID: 35658755 DOI: 10.1080/01635581.2022.2084122

20733 Masumoto K, Aihara Y, Miyagawa Kuroishi M, Maeda N, Sakai Y, Oka Y, Takahashi Y, Oda K, Yanagida M. Highly sensitive and non-disruptive detection of residual undifferentiated cells by measuring miRNAs in culture supernatant. Sci Rep 2022 12(1):10351 PubMed ID: 35725891 DOI: 10.1038/s41598-022-14273-z

20744 Asakawa R, Fuchiyama K, Ishii Y, Hosaka K, Kobayashi A, Shimazaki K, Nagasawa J, Tsuchida S, Ushida K, Matsubayashi M, Furuyama Y, Ohgane K, Kuramochi K. Synthesis and Cytotoxic Activities of 8- and 6-Demethyleucalyptins. Biosci Biotechnol Biochem 2022 PubMed ID: 35776954 DOI: 10.1093/bbb/zbac105

16724 Kenji Sugawara, Daichi Kanki, Ryuichi Watanabe, Ryoji Matsushima, Yuji Ise, Hisayoshi Yokose, Yasuhiro Morii, Nobuhiro Yamawaki, Akihiro Ninomiya, Shigeru Okada, Shigeki Matsunaga Aciculitin D, a cytotoxic heterodetic cyclic peptide from a Poecillastra sp. marine sponge Tetrahedron 2022 119:132859 DOI: 10.1016/j.tet.2022.132859

16725 Hasegawa T, Ito M, Hasegawa S, Teranishi M, Takeda K, Negishi S, Nishiwaki H, Takeda JI, LeBaron TW, Ohno K. Molecular Hydrogen Enhances Proliferation of Cancer Cells That Exhibit Potent Mitochondrial Unfolded Protein Response Int J Mol Sci 2022 23(5):2888 PubMed ID: 35270030 DOI: 10.3390/ijms23052888

20774 Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M. Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun 2022 13(1):4063 PubMed ID: 35831322 DOI: 10.1038/s41467-022-31690-w

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20846 Takahashi M, Sukowati EW, Nomura S, Kato A, Mizuseki K, Watanabe Y, Mukai H. Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours. J Drug Target 2022 1-12 PubMed ID: 36097977 DOI: 10.1080/1061186X.2022.2122477

20853 Uranbileg B, Kurano M, Kano K, Sakai E, Arita J, Hasegawa K, Nishikawa T, Ishihara S, Yamashita H, Seto Y, Ikeda H, Aoki J, Yatomi Y. Sphingosine 1-phosphate lyase facilitates cancer progression through converting sphingolipids to glycerophospholipids. Clin Transl Med 2022 12(9):e1056 PubMed ID: 36125914 DOI: 10.1002/ctm2.1056

20955 Morotomi-Yano K, Hiromoto Y, Higaki T, Yano KI. Disease-associated H58Y mutation affects the nuclear dynamics of human DNA topoisomerase IIβ. Sci Rep 2022 12(1):20627 PubMed ID: 36450898 DOI: 10.1038/s41598-022-24883-2

20968 Ciftci H, Sever B, Bayrak N, Yıldız M, Yıldırım H, Tateishi H, Otsuka M, Fujita M, TuYuN AF. In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights. Pharmaceuticals (Basel) 2022 15(10) PubMed ID: 36297378 DOI: 10.3390/ph15101266

13604 Jiang W, Jia N, Guo C, Wen J, Wu L, Ogi T, Zhang H. Predominant cellular mitochondrial dysfunction in the TOP3A gene-caused Bloom syndrome-like disorder Biochim Biophys Acta Mol Basis Dis 2021 1867(6):166106 PubMed ID: 33631320 DOI: 10.1016/j.bbadis.2021.166106

20083 Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K. Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues. Sci Rep 2021 11(1):6163 PubMed ID: 33731797 DOI: 10.1038/s41598-021-85603-w

15080 Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K. Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells Lab Invest 2021 101(8):1036-1047 PubMed ID: 33911189 DOI: 10.1038/s41374-021-00590-w

20272 Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R. Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA. Sci Rep 2021 11(1):13471 PubMed ID: 34188113 DOI: 10.1038/s41598-021-92860-2

20311 Ashizawa N, Shimizu H, Shoda K, Furuya S, Akaike H, Hosomura N, Kawaguchi Y, Amemiya H, Kawaida H, Sudo M, Inoue S, Kono H, Katsurahara K, Shiozaki A, Ichikawa D. NADPH oxidase 5 has a crucial role in cellular motility of colon cancer cells. Int J Oncol 2021 59(2) PubMed ID: 34278462 DOI: 10.3892/ijo.2021.5243

20372 Tamura N, Sakai S, Martorell L, Colomé R, Mizuike A, Goto A, Ortigoza-Escobar JD, Hanada K. Intellectual disability-associated mutations in the ceramide transport protein gene CERT1 lead to aberrant function and subcellular distribution. J Biol Chem 2021 101338 PubMed ID: 34688657 DOI: 10.1016/j.jbc.2021.101338

15709 Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y. Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis J Clin Invest 2021 131(17):e139933 PubMed ID: 34623325 DOI: 10.1172/JCI139933

15870 Sudo H, Kubo A. The Aneugenicity of Ketone Bodies in Colon Epithelial Cells Is Mediated by Microtubule Hyperacetylation and Is Blocked by Resveratrol Int J Mol Sci 2021 22(17):9397 PubMed ID: 34502304 DOI: 10.3390/ijms22179397

16051 Maruoka M, Zhang P, Mori H, Imanishi E, Packwood DM, Harada H, Kosako H, Suzuki J. Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane Mol Cell 2021 81(7):1397-1410.e9 PubMed ID: 33725486 DOI: 10.1016/j.molcel.2021.02.025

16067 Lazarova D, Semkova S, Zlateva G, Tatsuya H, Aoki I, Bakalova R. Quantum Sensors To Track Total Redox-Status and Oxidative Stress in Cells and Tissues Using Electron-Paramagnetic Resonance, Magnetic Resonance Imaging, and Optical Imaging Anal Chem 2021 93(5):2828-2837 PubMed ID: 33508934 DOI: 10.1021/acs.analchem.0c04116

16123 Zhou Y, Li X, Morita Y, Hachimura S, Miyakawa T, Takahashi S, Tanokura M. Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation Front Oncol9 2021 11:70593 PubMed ID: 34595111 DOI: 10.3389/fonc.2021.705939

16282 Hozaka Y, Kita Y, Yasudome R, Tanaka T, Wada M, Idichi T, Tanabe K, Asai S, Moriya S, Toda H, Mori S, Kurahara H, Ohtsuka T, Seki N. RNA-Sequencing Based microRNA Expression Signature of Colorectal Cancer: The Impact of Oncogenic Targets Regulated by miR-490-3p Int J Mol Sci 2021 22(18):9876 PubMed ID: 34576039 DOI: 10.3390/ijms22189876

6918 Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol 2020 27(2):186-196 PubMed ID: 31813846 DOI: 10.1016/j.chembiol.2019.11.010

9166 Yuka Nakazawa, Yuichiro Hara, Yasuyoshi Oka, Okiru Komine, Diana van den Heuvel, Chaowan Guo, Yasukazu Daigaku, Mayu Isono, Yuxi He, Mayuko Shimada, Kana Kato, Nan Jia, Satoru Hashimoto, Yuko Kotani, Yuka Miyoshi, Miyako Tanaka, Akira Sobue, Norisato Mitsutake, Takayoshi Suganami, Akio Masuda, Kinji Ohno, Shinichiro Nakada, Tomoji Mashimo, Koji Yamanaka, Martijn S Luijsterburg, Tomoo Ogi Ubiquitination of DNA Damage-Stalled RNAPII Promotes Transcription-Coupled Repair Cell 2020 180 (6), 1228-1244 PubMed ID: 32142649 DOI: 10.1016/j.cell.2020.02.010

9913 Satoshi Inoue, Takumi Tsunoda, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Ira Pastan, Kunio Kasugai, Kenji Kasai, Hiroshi Ikeda, Shingo Inaguma Diffuse Mesothelin Expression Leads to Worse Prognosis Through Enhanced Cellular Proliferation in Colorectal Cancer Oncol Lett 2020 19(3):1741-1750 PubMed ID: 32194667 DOI: 10.3892/ol.2020.11290

11905 Igarashi H, Taniguchi H, Nosho K, Ishigami K, Koide H, Mitsuhashi K, Okita K, Takemasa I, Imai K, Nakase H. PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer. Clin Transl Oncol 2020 22(7):1126-1137 PubMed ID: 31741141 DOI: 10.1007/s12094-019-02239-z

11910 Ujiie D, Okayama H, Saito K, Ashizawa M, Thar Min AK, Endo E, Kase K, Yamada L, Kikuchi T, Hanayama H, Fujita S, Sakamoto W, Endo H, Saito M, Mimura K, Saze Z, Momma T, Ohki S, Kono K. KRT17 as a prognostic biomarker for stage II colorectal cancer. Carcinogenesis 2020 41(5):591-599. PubMed ID: 31754689 DOI: 10.1093/carcin/bgz192

12035 Kitao A, Kawamoto S, Kurata K, Hayakawa I, Yamasaki T, Matsuoka H, Sumi Y, Kakeji Y, Kamesaki T, Minami H. Band 3 ectopic expression in colorectal cancer induces an increase in erythrocyte membrane-bound IgG and may cause immune-related anemia. Int. J. Hematol. 2020 PubMed ID: 31997080 DOI: 10.1007/s12185-020-02831-y

12130 Sanada S, Suzuki T, Nagata A, Hashidume T, Yoshikawa Y, Miyoshi N. Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob mice. Sci Rep 2020 PubMed ID: 32296105 DOI: 10.1038/s41598-020-63627-y

12136 Choodej, Khanitha Pudhom Cycloartane triterpenoids from the leaves of Euphorbia neriifolia Phytochemistry Letters 2020 DOI: 10.1016/j.phytol.2019.10.005

12150 Amira Mira, Mohamed A. Sabry, Kuniyoshi Shimizu & Fatma M. Abdel Bar A new pimarane-type diterpene obtained by biotransformation inhibits human HCT-116 colorectal carcinoma through inhibition of LTA4H activity Original Research 2020 DOI: 10.1007/s00044-020-02520-9

13059 Ratsada P, Hijiya N, Hidano S, Tsukamoto Y, Nakada C, Uchida T, Kobayashi T, Moriyama M. DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells. Biochem Biophys Res Commun 2020 PubMed ID: 32505357 DOI: 10.1016/j.bbrc.2020.05.140

13210 Wada Y, Morine Y, Imura S, Ikemoto T, Saito Y, Takasu C, Yamada S, Shimada M. HIF-1α expression in liver metastasis but not primary colorectal cancer is associated with prognosis of patients with colorectal liver metastasis. World J Surg Oncol 2020 PubMed ID: 32895059 DOI: 10.1186/s12957-020-02012-5

13220 Miyano K, Okamoto S, Yamauchi A, Kajikawa M, Kiyohara T, Taura M, Kawai C, Kuribayashi F. Constitutive activity of NADPH oxidase 1 (Nox1) that promotes its own activity suppresses the colon epithelial cell migration. Free Radic Res 2020 PubMed ID: 32924676 DOI: 10.1080/10715762.2020.1823383

13390 Murakami H, Tamura N, Enomoto Y, Shimasaki K, Kurosawa K, Hanada K. Intellectual disability-associated gain-of-function mutations in CERT1 that encodes the ceramide transport protein CERT. PLoS One 2020 PubMed ID: 33347465 DOI: 10.1371/journal.pone.0243980

13454 Wataru Matsunaga, Misa Ichikawa, Takahiro Ishikawa, Akinobu Gotoh Lentiviral vector-mediated transfection of human cancer cell lines with tumor suppressor genes inhibits proliferation in vitro Personalized Medicine Universe 2020 DOI: 10.46459/pmu.2020001

13502 Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K. GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer Cancer Sci 2020 111(2):343-355 PubMed ID: 31758608 DOI: 10.1111/cas.14248

13505 Oka S, Kuniba R, Tsuboi N, Tsuchida S, Ushida K, Tomoshige S, Kuramochi K. Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum Biosci Biotechnol Biochem 2020 84(1):31-36 PubMed ID: 31794330 DOI: 10.1080/09168451.2019.1662279

13902 Mito A, Kumazawa-Inoue K, Kojima-Aikawa K. ZG16p, an Animal Homologue of Plant β-Prism Fold Lectins: Purification Methods of Natural and Recombinant ZG16p and Inhibition Assay of Cancer Cell Growth Using ZG16p Methods Mol Biol 2020 2132:339-347 PubMed ID: 32306341 DOI: 10.1007/978-1-0716-0430-4_33

14364 Kohzaki M, Ootsuyama A, Sun L, Moritake T, Okazaki R. Human RECQL4 represses the RAD52-mediated single-strand annealing pathway after ionizing radiation or cisplatin treatment Int J Cancer 2020 146(11):3098-3113 PubMed ID: 31495919 DOI: 10.1002/ijc.32670

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14875 Mizuno M, Mori K, Tsuchiya K, Takaki T, Misawa T, Demizu Y, Shibanuma M, Fukuhara K. Design, Synthesis, and Biological Activity of Conformationally Restricted Analogues of Silibinin ACS Omega 2020 5(36):23164-23174 PubMed ID: 32954167 DOI: 10.1021/acsomega.0c02936

11388 Kitada K, Pu F, Toi M. Occurrence of senescence-escaping cells in doxorubicin-induced senescence is enhanced by PD0332991, a cyclin-dependent kinase 4/6 inhibitor, in colon cancer HCT116 cells. Oncol Lett 2019 PubMed ID: 30655877 DOI: 10.3892/ol.2018.9657

11359 Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K. CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. Anticancer Res. 2019 PubMed ID: 30591445 DOI: 10.21873/anticanres.13084

11408 Suzuki N, Niikura R, Ihara S, Hikiba Y, Kinoshita H, Higashishima N, Hayakawa Y, Yamada A, Hirata Y, Nakata R, Okamoto M, Sano M, Kushiyama A, Ichinose M, Woods SL, Worthley D, Iwamoto Y, Koike K. Alpha-Blockers As Colorectal Cancer Chemopreventive: Findings from a Case-Control Study, Human Cell Cultures, and In Vivo Preclinical Testing. Cancer Prev Res (Phila) 2019 PubMed ID: 30700439 DOI: 10.1158/1940-6207.CAPR-18-0288

11517 Sekido M, Fujita KI, Kubota Y, Ishida H, Takahashi T, Ohkuma R, Tsunoda T, Ishikawa F, Shibanuma M, Sasaki Y. Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil. Cancer Chemother. Pharmacol. 2019 PubMed ID: 30972456 DOI: 10.1007/s00280-019-03837-y

11724 Othman DIA, Selim KB, El-Sayed MA, Tantawy AS, Amen Y, Shimizu K, Okauchi T, Kitamura M. Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives. Bioorg. Med. Chem. 2019 PubMed ID: 31416740 DOI: 10.1016/j.bmc.2019.07.042

11725 Kawasaki Y, Miyamoto M, Oda T, Matsumura K, Negishi L, Nakato R, Suda S, Yokota N, Shirahige K, Akiyama T. The novel lncRNA CALIC upregulates AXL to promote colon cancer metastasis. EMBO Rep. 2019 PubMed ID: 31353791 DOI: 10.15252/embr.201847052

11835 Yokoyama Y, Sakatani T, Wada R, Ishino K, Kudo M, Koizumi M, Yamada T, Yoshida H, Naito Z. In vitro and in vivo studies on the association of long non‑coding RNAs H19 and urothelial cancer associated 1 with the susceptibility to 5‑fluorouracil in rectal cancer. Int. J. Oncol. 2019 PubMed ID: 31638183 DOI: 10.3892/ijo.2019.4895

11851 Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T. Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction. Sci Rep 2019 PubMed ID: 31611630 DOI: 10.1038/s41598-019-51462-9

11864 Matsumoto Y, Kuriki H, Kitamura T, Takahashi D, Toshima K. Total Synthesis and Structure-Activity Relationship Study of Vineomycin A1. J. Org. Chem. 2019 PubMed ID: 31642324 DOI: 10.1021/acs.joc.9b02304

12405 Kouyama Y, Masuda T, Fujii A, Ogawa Y, Sato K, Tobo T, Wakiyama H, Yoshikawa Y, Noda M, Tsuruda Y, Kuroda Y, Eguchi H, Ishida F, Kudo SE, Mimori K. Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer Cancer Sci 2019 110(10):3132-3144 PubMed ID: 31390121 DOI: 10.1111/cas.14163

12420 Aoki T, Nishita M, Sonoda J, Ikeda T, Kakeji Y, Minami Y. Intraflagellar transport 20 promotes collective cancer cell invasion by regulating polarized organization of Golgi-associated microtubules Cancer Sci 2019 110(4):1306-1316 PubMed ID: 30742741 DOI: 10.1111/cas.13970

12421 Koike M, Yutoku Y, Koike A. Feline XLF accumulates at DNA damage sites in a Ku-dependent manner FEBS Open Bio 2019 9(6):1052-1062 PubMed ID: 31115163 DOI: 10.1002/2211-5463.12589

12422 Miyagi A, Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T. Dimethyl Fumarate Attenuates Oxaliplatin-Induced Peripheral Neuropathy without Affecting the Anti-tumor Activity of Oxaliplatin in Rodents Biol Pharm Bull 2019 42(4):638-644. PubMed ID: 30930422 DOI: 10.1248/bpb.b18-00855

12423 Wang-Bishop L, Chen Z, Gomaa A, Lockhart AC, Salaria S, Wang J, Lewis KB, Ecsedy J, Washington K, Beauchamp RD, El-Rifai W. Inhibition of AURKA Reduces Proliferation and Survival of Gastrointestinal Cancer Cells With Activated KRAS by Preventing Activation of RPS6KB1 Gastroenterology 2019 156(3):662-675.e7 PubMed ID: 30342037 DOI: 10.1053/j.gastro.2018.10.030

12424 Kawashiri T, Shimizu S, Shigematsu N, Kobayashi D, Shimazoe T. Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect J Pharmacol Sci 2019 140(3):291-294 PubMed ID: 31377017 DOI: 10.1016/j.jphs.2019.05.009

12517 Satria D, Amen Y, Niwa Y, Ashour A, Allam AE, Shimizu K. Lucidumol D, a new lanostane-type triterpene from fruiting bodies of Reishi (Ganoderma lingzhi) Nat Prod Res 2019 33(2):189-195 PubMed ID: 29457741 DOI: 10.1080/14786419.2018.1440229

14360 Ashizawa M, Okayama H, Ishigame T, Thar Min AK, Saito K, Ujiie D, Murakami Y, Kikuchi T, Nakayama Y, Noda M, Tada T, Endo H, Fujita S, Sakamoto W, Saito M, Saze Z, Momma T, Ohki S, Mimura K, Kono K. miRNA-148a-3p Regulates Immunosuppression in DNA Mismatch Repair-Deficient Colorectal Cancer by Targeting PD-L1 Mol Cancer Res 2019 17(6):1403-1413 PubMed ID: 30872332 DOI: 10.1158/1541-7786.MCR-18-0831

9501 Shiota M, Naya M, Yamamoto T, Hishiki T, Tani T, Takahashi H, Kubo A, Koike D, Itoh M, Ohmura M, Kabe Y, Sugiura Y, Hiraoka N, Morikawa T, Takubo K, Suina K, Nagashima H, Sampetrean O, Nagano O, Saya H, Yamazoe S, Watanabe H, Suematsu M. Gold-nanofève surface-enhanced Raman spectroscopy visualizes hypotaurine as a robust anti-oxidant consumed in cancer survival. Nat Commun 2018 9:1561 PubMed ID: 29674746 DOI: 10.1038/s41467-018-03899-1

10580 Mito A, Nakano Y, Saitoh T, Gouraud SSS, Yamaguchi Y, Sato T, Sasaki N, Kojima-Aikawa K. Lectin ZG16p inhibits proliferation of human colorectal cancer cells via its carbohydrate-binding sites. Glycobiology 2018 28:21-31 PubMed ID: 29069492 DOI: 10.1093/glycob/cwx088

10606 Kanno E, Kawasaki O, Takahashi K, Takano K, Endo T. DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor. Exp. Cell Res. 2018 362:111-120 PubMed ID: 29129563 DOI: 10.1016/j.yexcr.2017.11.008

10702 Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y. Mechanism of recipient cell-dependent differences in exosome uptake. BMC Cancer 2018 18:47 PubMed ID: 29306323 DOI: 10.1186/s12885-017-3958-1

10751 Noguchi A, Adachi S, Yokota N, Hatta T, Natsume T, Kawahara H. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Biol Open 2018 7: PubMed ID: 29449217 DOI: 10.1242/bio.031575

10757 Seiler M, Yoshimi A, Darman R, Chan B, Keaney G, Thomas M, Agrawal AA, Caleb B, Csibi A, Sean E, Fekkes P, Karr C, Klimek V, Lai G, Lee L, Kumar P, Lee SC, Liu X, Mackenzie C, Meeske C, Mizui Y, Padron E, Park E, Pazolli E, Peng S, Prajapati S, Taylor J, Teng T, Wang J, Warmuth M, Yao H, Yu L, Zhu P, Abdel-Wahab O, Smith PG, Buonamici S. H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers. Nat. Med. 2018 24:497-504 PubMed ID: 29457796 DOI: 10.1038/nm.4493

10847 Kojima K, Nakamura T, Ohbu M, Katoh H, Ooizumi Y, Igarashi K, Ishii S, Tanaka T, Yokoi K, Nishizawa N, Yokota K, Kosaka Y, Sato T, Watanabe M, Yamashita K. Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. PLoS ONE 2018 13:e0194785 PubMed ID: 29746493 DOI: 10.1371/journal.pone.0194785

11009 Evidence suggesting sphingosine 1-phosphate may be actively generated, degraded and transported to extracellular spaces with increased S1P2 and S1P3 expressions in colon cancer Clinical Colorectal Cancer 2018 17, e171-e182 PubMed ID: 29223361 DOI: 10.1016/j.clcc.2017.11.004

11087 Thar Min AK, Okayama H, Saito M, Ashizawa M, Aoto K, Nakajima T, Saito K, Hayase S, Sakamoto W, Tada T, Hanayama H, Saze Z, Momma T, Ohki S, Sato Y, Motoyama S, Mimura K, Kono K. Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma. Cancer Med 2018 PubMed ID: 29855157 DOI: 10.1002/cam4.1564

4422 Enos Tangke Arung, Rudianto Amirta, Qinchang Zhu, Yhiya Amen, Kuniyoshi Shimizu Effect of wood, bark and leaf extracts of Macaranga trees on cytotoxic activity in some cancer and normal cell lines Journal of the Indian Academy of Wood Science 2018 5, 115–119 DOI: 10.1007/s13196-018-0215-4

4195 Ishigaki Y, Sato K. Effects of Microchannel Shape and Ultrasonic Mixing on Microfluidic Padlock Probe Rolling Circle Amplification (RCA) Reactions. Micromachines (Basel) 2018 PubMed ID: 30424205 DOI: 10.3390/mi9060272

4196 Wada F, Koga H, Akiba J, Niizeki T, Iwamoto H, Ikezono Y, Nakamura T, Abe M, Masuda A, Sakaue T, Tanaka T, Kakuma T, Yano H, Torimura T. High expression of CD44v9 and xCT in chemoresistant hepatocellular carcinoma: Potential targets by sulfasalazine. Cancer Sci. 2018 PubMed ID: 29981246 DOI: 10.1111/cas.13728

4344 Li HK, Hasegawa S, Nakajima NI, Morokoshi Y, Minegishi K, Nagatsu K. Targeted cancer cell ablation in mice by an α-particle-emitting astatine-211-labeled antibody against major histocompatibility complex class I chain-related protein A and B. Biochem. Biophys. Res. Commun. 2018 PubMed ID: 30409432 DOI: 10.1016/j.bbrc.2018.10.157

4476 Bardales JA, Wieser E, Kawaji H, Murakawa Y, Darzacq X. Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers. Genes (Basel) 2018 9(6) PubMed ID: 29882899 DOI: 10.3390/genes9060270

14526 Yamada NO, Wenduerma, Matsuda S, Senda T. Validation and application of a novel APC antibody in western blotting, immunoprecipitation, and immunohistochemistry Med Mol Morphol 2018 51(4):227-236 PubMed ID: 29923125 DOI: 10.1007/s00795-018-0196-9

14901 Enjoji S, Yabe R, Tsuji S, Yoshimura K, Kawasaki H, Sakurai M, Sakai Y, Takenouchi H, Yoshino S, Hazama S, Nagano H, Oshima H, Oshima M, Vitek MP, Matsuura T, Hippo Y, Usui T, Ohama T, Sato K. Stemness Is Enhanced in Gastric Cancer by a SET/PP2A/E2F1 Axis Mol Cancer Res 2018 16(3):554-563 PubMed ID: 29330298 DOI: 10.1158/1541-7786.MCR-17-0393

14906 Noda M, Okayama H, Tachibana K, Sakamoto W, Saito K, Thar Min AK, Ashizawa M, Nakajima T, Aoto K, Momma T, Katakura K, Ohki S, Kono K. Glycosyltransferase Gene Expression Identifies a Poor Prognostic Colorectal Cancer Subtype Associated with Mismatch Repair Deficiency and Incomplete Glycan Synthesis Clin Cancer Res 2018 24(18):4468-4481 PubMed ID: 29844132 DOI: 10.1158/1078-0432.CCR-17-3533

9847 Koike M, Yutoku Y, Koike A. Cloning, localization and focus formation at DNA damage sites of canine XRCC4. J. Vet. Med. Sci. 2017 78:1865-1871 PubMed ID: 27644316 DOI: 10.1292/jvms.16-0381

10185 Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M. Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer. Br. J. Cancer 2017 116:1046-1056 PubMed ID: 28291773 DOI: 10.1038/bjc.2017.65

10296 Gombodorj N, Yokobori T, Yoshiyama S, Kawabata-Iwakawa R, Rokudai S, Horikoshi I, Nishiyama M, Nakano T. Inhibition of Ubiquitin-conjugating Enzyme E2 May Activate the Degradation of Hypoxia-inducible Factors and, thus, Overcome Cellular Resistance to Radiation in Colorectal Cancer. Anticancer Res. 2017 37:2425-2436 PubMed ID: 28476810 DOI: 10.21873/anticanres.11582

10498 Inaguma S, Lasota J, Felisiak-Golabek A, Kowalik A, Wang Z, Zieba S, Kalisz J, Ikeda H, Miettinen M. Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression. J Pathol Clin Res 2017 3:268-278 PubMed ID: 29085667 DOI: 10.1002/cjp2.81

10520 Koike M, Yutoku Y, Koike A. Cloning of canine Ku80 and its localization and accumulation at DNA damage sites. FEBS Open Bio 2017 7:1854-1863 PubMed ID: 29226073 DOI: 10.1002/2211-5463.12311

10535 Ohashi W, Yamamine N, Imura J, Hattori Y. SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem. Biophys. Res. Commun. 2017 493:1342-1348 PubMed ID: 28970068 DOI: 10.1016/j.bbrc.2017.09.161

4194 Satoh T, Sugiura S, Shin K, Onuki-Nagasaki R, Ishida S, Kikuchi K, Kakiki M, Kanamori T. A multi-throughput multi-organ-on-a-chip system on a plate formatted pneumatic pressure-driven medium circulation platform. Lab Chip 2017 PubMed ID: 29184959 DOI: 10.1039/c7lc00952f

10028 Michinori Takashina, Sayaka Inoue, Kei Tomihara, Kengo Tomita, Kohshi Hattori, Qing-Li Zhao, Tokiko Suzuki, Makoto Noguchi, Wakana Ohashi, Yuichi Hattori Different Effect of Resveratrol to Induction of Apoptosis Depending on the Type of Human Cancer Cells Int J Oncol 2017 50(3):787-797. PubMed ID: 28197625 DOI: 10.3892/ijo.2017.3859

14055 Morishita S, Suzuki T, Niwa Y, Dohmae N, Simizu S. Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines Oncol Lett 2017 14(2):2537-2544 PubMed ID: 28781692 DOI: 10.3892/ol.2017.6465

14621 Koike M, Yutoku Y, Koike A. Cloning, localization and focus formation at DNA damage sites of canine Ku70 J Vet Med Sci 2017 79(3):554-561 PubMed ID: 28163277 DOI: 10.1292/jvms.16-0649

14642 Egashira I, Takahashi-Yanaga F, Nishida R, Arioka M, Igawa K, Tomooka K, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Kitazono T, Sasaguri T. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway Cancer Sci 2017 108(1):108-115 PubMed ID: 27761963 DOI: 10.1111/cas.13106

9637 Li W, Itou J, Tanaka S, Nishimura T, Sato F, Toi M. A homeobox protein, NKX6.1, up-regulates interleukin-6 expression for cell growth in basal-like breast cancer cells. Exp. Cell Res. 2016 343:177-189 PubMed ID: 27032575 DOI: 10.1016/j.yexcr.2016.03.023

10913 Clinical potential of DAC-70 sol Integr Mol Med 2016 3: 645-648 DOI: 10.15761/IMM.1000216

12896 Koizumi S, Irie T, Hirayama S, Sakurai Y, Yashiroda H, Naguro I, Ichijo H, Hamazaki J, Murata S. The aspartyl protease DDI2 activates Nrf1 to compensate for proteasome dysfunction Elife 2016 5:e18357 PubMed ID: 27528193 DOI: 10.7554/eLife.18357

13474 Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, Nishizuka SS. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15 Sci Rep 2016 6:25895 PubMed ID: 27181033 DOI: 10.1038/srep25895

13991 Tanaka G, Inoue K, Shimizu T, Akimoto K, Kubota K. Dual pharmacological inhibition of glutathione and thioredoxin systems synergizes to kill colorectal carcinoma stem cells Cancer Med 2016 5(9):2544-57 PubMed ID: 27485632 DOI: 10.1002/cam4.844

14105 Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M. SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer Cancer Sci 2016 107(5):619-28 PubMed ID: 26892864 DOI: 10.1111/cas.12909

7305 Yamada K, Maishi N, Akiyama K, Towfik Alam M, Ohga N, Kawamoto T, Shindoh M, Takahashi N, Kamiyama T, Hida Y, Taketomi A, Hida K. CXCL12-CXCR7 axis is important for tumor endothelial cell angiogenic property. Int. J. Cancer 2015 137:2825-36 PubMed ID: 26100110 DOI: 10.1002/ijc.29655

7560 Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K Standard WT1 Expression Using Immunohistochemistry. J Mol Biomark Diagn 2015 7:266 DOI: 10.4172/2155-9929.1000266

14459 Ogawa H, Wu X, Kawamoto K, Nishida N, Konno M, Koseki J, Matsui H, Noguchi K, Gotoh N, Yamamoto T, Miyata K, Nishiyama N, Nagano H, Yamamoto H, Obika S, Kataoka K, Doki Y, Mori M, Ishii H. MicroRNAs Induce Epigenetic Reprogramming and Suppress Malignant Phenotypes of Human Colon Cancer Cells PLoS One 2015 10(5):e0127119 PubMed ID: 25970424 DOI: 10.1371/journal.pone.0127119

15139 Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura K, Baba H, Ohmuraya M. SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer Mol Cancer Res 2015 13(7):1130-8 PubMed ID: 25804623 DOI: 10.1158/1541-7786.MCR-14-0581

15210 Guo C, Nakazawa Y, Woodbine L, Björkman A, Shimada M, Fawcett H, Jia N, Ohyama K, Li TS, Nagayama Y, Mitsutake N, Pan-Hammarström Q, Gennery AR, Lehmann AR, Jeggo PA, Ogi T. XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency J Allergy Clin Immunol 2015 136(4):1007-17 PubMed ID: 26255102 DOI: 10.1016/j.jaci.2015.06.007

4397 Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol 2011 32(4):729-35 PubMed ID: 21523445 DOI: 10.1007/s13277-011-0174-5