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Cell No. : Cell Name
RCB2860 : MRMT-1  update : 2024/07/17
CommentRat cell line derived from mammary carcinoma. TKG0132 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Fukuda, Hiroshi
Year of deposit 2008
Original cell TKG0132
Animal _rat < Mammals
Strain name SD
Gender Female
Tissue mammary gland
Disease name mammary carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0132)
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_5156
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture or Medium Renewal : once/2-3 days
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
Isozyme LD, NP, AST
deposit info
lot info
Reference information Reference 3
User's Publication 12

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5360  Harada Y.  Pituitary role in the growth of metastasizing MRMT-1 mammary carcinoma in rats.  Cancer Res  1976  36(1):18-22  PubMed ID: 1247997  
5359  Harada Y.  Induction of metastasizing carcinoma in rats and their biological characteristics.  Acta Pathol Jpn  1975  25(4):451-61  PubMed ID: 170787   DOI: 10.1111/j.1440-1827.1975.tb00865.x
5358  Arita H, Kawanami J.  Cytolipin R and its possible precursor ceramide trisaccharide from metastatic rat mammary tumor.  J Biochem  1974  76(5):1067-74  PubMed ID: 4375678  

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User's Publication
19994  Jerard C, Madhusudanan P, Swamy A, Ravikumar K, Shankarappa SA.  Secretome mediated interactions between sensory neurons and breast cancer cells  Int J Cancer  2023  153(2):427-436  PubMed ID: 37067100   DOI: 10.1002/ijc.34529
12523  Kucharczyk MW, Chisholm KI, Denk F, Dickenson AH, Bannister K, McMahon SB.  The impact of bone cancer on the peripheral encoding of mechanical pressure stimuli  Pain  2020  161(8):1894-1905  PubMed ID: 32701848   DOI: 10.1097/j.pain.0000000000001880
11353  Falk S, Appel CK, Bennedbæk HB, Al-Dihaissy T, Unger A, Dinkel K, Heegaard AM.  Chronic high dose P2X7 receptor inhibition exacerbates cancer-induced bone pain.  Eur. J. Pharmacol.  2019    PubMed ID: 30582910   DOI: 10.1016/j.ejphar.2018.12.032
10314  Oka S, Kanagawa M, Doi Y, Schuster DM, Goodman MM, Yoshimura H.  PET Tracer 18F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models.  Theranostics  2017  7:2048-2064  PubMed ID: 28656060   DOI: 10.7150/thno.19883
14754  Oka S, Kanagawa M, Doi Y, Schuster DM, Goodman MM, Yoshimura H.  Fasting Enhances the Contrast of Bone Metastatic Lesions in 18 F-Fluciclovine-PET: Preclinical Study Using a Rat Model of Mixed Osteolytic/Osteoblastic Bone Metastases  Int J Mol Sci  2017  18(5):934  PubMed ID: 28468238   DOI: 10.3390/ijms18050934
14584  Effects of Src-kinase inhibition in cancer-induced bone pain  Effects of Src-kinase inhibition in cancer-induced bone pain  Mol Pain  2016  12:1744806916643725  PubMed ID: 27094550   DOI: 10.1177/1744806916643725
7478  Falk S, Schwab SD, Frosig-Jorgensen M, Clausen RP, Dickenson AH, Heegaard AM.  P2X7 receptor-mediated analgesia in cancer-induced bone pain.  Neuroscience  2015  291:93-105  PubMed ID: 25686524   DOI: 10.1016/j.neuroscience.2015.02.011
5361  Falk S, Patel R, Heegaard A, Mercadante S, Dickenson AH.  Spinal neuronal correlates of tapentadol analgesia in cancer pain: a back-translational approach.  Eur J Pain  2015  19(2):152-8  PubMed ID: 24917026   DOI: 10.1002/ejp.530
5362  Falk S, Ipsen DH, Appel CK, Ugarak A, Durup D, Dickenson AH, Heegaard AM.  Randall Selitto pressure algometry for assessment of bone-related pain in rats.  Eur J Pain  2015  19(3):305-12  PubMed ID: 25057115   DOI: 10.1002/ejp.547
5363  Varani K, Vincenzi F, Targa M, Paradiso B, Parrilli A, Fini M, Lanza G, Borea PA.  The stimulation of A(3) adenosine receptors reduces bone-residing breast cancer in a rat preclinical model.  Eur J Cancer  2013  49(2):482-91  PubMed ID: 22770890   DOI: 10.1016/j.ejca.2012.06.005
5364  Fini M, Salamanna F, Parrilli A, Martini L, Cadossi M, Maglio M, Borsari V.  Electrochemotherapy is effective in the treatment of rat bone metastases.  Clin Exp Metastasis  2013  30(8):1033-45  PubMed ID: 23832763   DOI: 10.1007/s10585-013-9601-x
5365  Vincenzi F, Targa M, Corciulo C, Tabrizi MA, Merighi S, Gessi S, Saponaro G, Baraldi PG, Borea PA, Varani K.  Antinociceptive effects of the selective CB2 agonist MT178 in inflammatory and chronic rodent pain models.  Pain  2013  154(6):864-73  PubMed ID: 23518609   DOI: 10.1016/j.pain.2013.02.007

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