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細胞番号 : 細胞名
RCB2782 : RBL 2H3  update : 2021/08/10
細胞特性(Comment:英)Rat cell line derived from basophilic leukemia cells. TKG0321 (Deposited from Tohoku Univ.).
細胞特性(日)ラット好塩基性白血病細胞由来細胞株。 TKG0321 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Fukuda, Hiroshi
樹立者 Siraganian, R. & Eccleston.
寄託日 2008
元の細胞 TKG0321
動物種 _rat < Mammals
採取組織 peripheral blood
細胞分類 cancer
入手歴 Maeyama, K. & Tanno, Y. → Cell Resource Center for Biomedical Research, Tohoku University(TKG0321)
細胞寿命 infinite
細胞形態 other
Cellosaurus(Expasy) CVCL_0591
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 MEM + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
動物種PCR OK
アイソザイム検査 LD, NP, G6PD, AST
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 3件
Reference(日) 0件
利用者成果(英) 24件
利用者成果(日) 0件

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Reference(英)
5269  Morita Y, Siraganian RP.  Inhibition of IgE-mediated histamine release from rat basophilic leukemia cells and rat mast cells by inhibitors of transmethylation.  J Immunol  1981  127(4):1339-44  PubMed ID: 6168684
5268  Anthony Kulczycki, Chaviva Isersky, Henry Metzger  THE INTERACTION OF IgE WITH RAT BASOPHILIC LEUKEMIA CELLS. I. EVIDENCE FOR SPECIFIC BINDING 0]~ IgE   J Exp Med  1974  139(3):600-16 
5267  Eccleston E, Leonard BJ, Lowe JS, Welford HJ.  Basophilic leukaemia in the albino rat and a demonstration of the basopoietin.  Nat New Biol  1973  244(133):73-6  PubMed ID: 4516144

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Reference(日)

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利用者成果(英)
13447  Lin YANG, Xianwei ZHU, Minoru SUGA, Hiroaki SHINOHARA  Evaluation of the Anti-Allergic Effect of Natural Medicines on Mast Cell by Using Two-Dimensional Surface Plasmon Resonance Observation  Electrochemistry  2021/1/1   
11451  Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K.  Inhibition of mast cell degranulation by melanin.  Biochem. Pharmacol.  2019    PubMed ID: 30796915
11670  Xiaolu He, Akiko Yamauchi, Toshiki Nakano, Toshiyasu Yamaguchi, Yoshihiro Ochiai  The composition and anti-inflammatory effect of polysaccharides from the red alga Chondrus verrucosus  Fisheries Science  2019   
10538  Mwakalu kwa, Ahmed Ashour, Yhiya Amen, Yasuharu Niwa, Sonam Tamrakar, Tomofumi Miyamoto, Kuniyoshi Shimizu  Anti-allergic activity of polyphenolic compounds isolated from olive mill wastes  Journal of Functional Foods  2019  58:207-217 
9997  Kamei R, Fujimura T, Matsuda M, Kakihara K, Hirakawa N, Baba K, Ono K, Arakawa K, Kawamoto S.  A flavanone derivative from the Asian medicinal herb (Perilla frutescens) potently suppresses IgE-mediated immediate hypersensitivity reactions.  Biochem. Biophys. Res. Commun.  2017  483:674-679  PubMed ID: 27986566
10063  Kishikawa A, Amen Y, Shimizu K.  Anti-allergic triterpenes isolated from olive milled waste.  Cytotechnology  2017  69:307-315  PubMed ID: 28074390
10307  Tan H, Sonam T, Shimizu K.  The Potential of Triterpenoids from Loquat Leaves (Eriobotrya japonica) for Prevention and Treatment of Skin Disorder.  Int J Mol Sci  2017  18:  PubMed ID: 28492484
7140  Shi YH, Zhu S, Ge YW, He YM, Kazuma K, Wang Z, Yoshimatsu K, Komatsu K.  Monoterpene derivatives with anti-allergic activity from red peony root, the root of Paeonia lactiflora.  Fitoterapia  2016  108:55-61  PubMed ID: 26598138
7145  Nakakita S, Itoh A, Nakakita Y, Nonaka Y, Ogawa T, Nakamura T, Nishi N.  Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9.  J. Biol. Chem.  2016  291:968-79  PubMed ID: 26582205
9552  Shi YH, Zhu S, Tamura T, Kadowaki M, Wang Z, Yoshimatsu K, Komatsu K.  Chemical constituents with anti-allergic activity from the root of Edulis Superba, a horticultural cultivar of Paeonia lactiflora.  J Nat Med  2016  70:234-40  PubMed ID: 26833191
10857    Clinical Evaluation of Novel Natural Polysaccharides Sacran as a Skincare Material for Atopic Dermatitis Patients   Journal of Cosmetics, Dermatological Sciences and Applications  2016  6, 9-18 
7437  Kishikawa A, Ashour A, Zhu Q, Yasuda M, Ishikawa H, Shimizu K.  Multiple Biological Effects of Olive Oil By-products such as Leaves, Stems, Flowers, Olive Milled Waste, Fruit Pulp, and Seeds of the Olive Plant on Skin.  Phytother Res  2015  29:877-86  PubMed ID: 25779104
7473  Sato A, Tamura H.  High antiallergic activity of 5,6,4'-trihydroxy-7,8,3'-trimethoxyflavone and 5,6-dihydroxy-7,8,3',4'-tetramethoxyflavone from eau de cologne mint (Mentha×piperita citrata).  Fitoterapia  2015  102:74-83  PubMed ID: 25704366
7520  Akihiko Sato, Ting Zhang, Lina Yonekura, Hirotoshi Tamura.  Antiallergic activities of eleven onions (Allium cepa) were attributed to quercetin 4'-glucoside using QuEChERS method and Pearson's correlation coefficient.  J Functional Foods  2015  14:581-589 
7540  Kobayashi S, Kato T, Azuma T, Kikuzaki H, Abe K..  Anti-allergenic activity of polymethoxyflavones from Kaempferia parviflora.  J Functional Foods  2015  13:100-107 
7554  Q. Zhu, T. Nakagawa, A. Kishikawa, K. Ohnuki, K. Shimizu  In vitro bioactivities and phytochemical profile of various parts of the strawberry (Fragaria × ananassa var.?Amaou).  J Functional Foods  2015  13:38-49 
10950  Akihiko, Sato et al  Antialleric Activity of varius kinds of vegetables and Fruits in japan and thailand  Conference: Journal of Science and Technology  2014  52B, 726-735 
10261  Mitsuteru Irie, Junkyu Han, Atsushi Kawachi, Jamila Tarhouni, Mohamed Ksibi, Kenichi Kashiwagi & Hiroko Isoda  In Vitro Testing and Commercialization Potential of Extracted Fulvic Acid from Dredged Sediment from Arid Region Reservoirs  Waste and Biomass Valorization  2014  5:273–281 
9479  Amira Mira, Akinobu Tanaka, Yumie Tateyama, Ryuichiro Kondo, Kuniyoshi Shimizu  Comparative Biological Study of Roots, Stems, Leaves, and Seeds of Angelica Shikokiana Makino  J Ethnopharmacol  2013  148(3):980-7  PubMed ID: 23769982
7986  Kawamoto S, Kaneoke M, Ohkouchi K, Amano Y, Takaoka Y, Kume K, Aki T, Yamashita S, Watanabe K, Kadowaki M, Hirata D, Ono K.  Sake lees fermented with lactic acid bacteria prevents allergic rhinitis-like symptoms and IgE-mediated basophil degranulation.  Biosci. Biotechnol. Biochem.  2011  75:140-4  PubMed ID: 21228477
8680  Parida Yamada, Moktar Zarrouk, Hiroko Isoda  Screening of Various Tunisian Olive Oils for Their Inhibitory Effect on Beta-Hexosaminidase Release by Basophilic Cells  Animal Cell Technology: Basic & Applied Aspects  2009  231-238: 
5880  Rieko IIJIMA1, Parida YAMADA1, Junkyu HAN1, Hideyuki SHIGEMORI, Hiroko ISODA  Anti-allergic Effect of Acteoside Derived from Arid Land Plant Cistanche tubulosa  Journal of Arid Land Studies   2009  9-1:383- 386 
12784  Yamada P, Zarrouk M, Kawasaki K, Isoda H.  Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells  J Ethnopharmacol  2008  116(2):279-87  PubMed ID: 18178046
14933  Murakami M, Yoshihara K, Shimbara S, Lambeau G, Singer A, Gelb MH, Sawada M, Inagaki N, Nagai H, Kudo I.  Arachidonate release and eicosanoid generation by group IIE phospholipase A(2)  Biochem Biophys Res Commun  2002  292(3):689-96  PubMed ID: 11922621

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