| 利用者成果(英) |
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21765
Ferretti GDS, Quaas CE, Bertolini I, Zuccotti A, Saatci O, Kashatus JA, Sharmin S, Lu DY, Poli ANR, Quesnelle AF, Rodriguez-Blanco J, de Cubas AA, Hobbs GA, Liu Q, O'Bryan JP, Salvino JM, Kashatus DF, Sahin O, Barnoud T.
HSP70-mediated mitochondrial dynamics and autophagy represent a novel vulnerability in pancreatic cancer.
Cell Death Differ
2024
PubMed ID: 38802657
DOI: 10.1038/s41418-024-01310-9
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18285
Yamakawa K, Koyanagi-Aoi M, Machinaga A, Kakiuchi N, Hirano T, Kodama Y, Aoi T.
Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase
Cancer Cell Int
2023
23(1):94
PubMed ID: 37198667
DOI: 10.1186/s12935-023-02928-4
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18288
Kudo Y, Suzuki H, Tanaka T, Kaneko MK, Kato Y.
Development of a Novel Anti-CD44 Variant 5 Monoclonal Antibody C44Mab-3 for Multiple Applications against Pancreatic Carcinomas
Antibodies (Basel)
2023
12(2):31
PubMed ID: 37218897
DOI: 10.3390/antib12020031
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19722
Masuda T, Fukuda A, Yamakawa G, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Nagao M, Araki O, Yoshikawa T, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Masui T, Hatano E, Matsuzaki T, Noda M, Seno H.
Pancreatic RECK inactivation promotes cancer formation, epithelial-mesenchymal transition, and metastasis
J Clin Invest
2023
133(18):e161847
PubMed ID: 37712427
DOI: 10.1172/JCI161847
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19807
Shichi Y, Gomi F, Hasegawa Y, Nonaka K, Shinji S, Takahashi K, Ishiwata T.
Artificial intelligence-based analysis of time-lapse images of sphere formation and process of plate adhesion and spread of pancreatic cancer cells
Front Cell Dev Biol
2023
11:1290753
PubMed ID: 38046666
DOI: 10.3389/fcell.2023.1290753
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21397
Sathiyaseelan P, Chittaranjan S, Kalloger SE, Chan J, Go NE, Jardon MA, Ho CJ, Hui T, Xu J, Chow C, Gao D, Johnson FD, Lockwood WW, Morin GB, Renouf DJ, Schaeffer DF, Gorski SM.
ATG4B and ATG4A loss result in two-stage cell cycle defects in pancreatic ductal adenocarcinoma cells.
J Cell Sci
2023
PubMed ID: 37701987
DOI: 10.1242/jcs.260644
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21412
Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T.
Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer.
JCI Insight
2023
PubMed ID: 37733442
DOI: 10.1172/jci.insight.163022
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17527
Sasaki N, Hirano K, Shichi Y, Gomi F, Yoshimura H, Matsushita A, Toyoda M, Ishiwata T.
Gp130-Mediated STAT3 Activation Contributes to the Aggressiveness of Pancreatic Cancer through H19 Long Non-Coding RNA Expression
Cancers (Basel)
2022
14(9):2055
PubMed ID: 35565185
DOI: 10.3390/cancers14092055
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18221
Shichi Y, Gomi F, Sasaki N, Nonaka K, Arai T, Ishiwata T.
Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures
J Pers Med
2022
12(5):746
PubMed ID: 35629168
DOI: 10.3390/jpm12050746
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20538
Hassan G, Ohara T, Afify SM, Kumon K, Zahra MH, Fu X, Al Kadi M, Seno A, Salomon DS, Seno M.
Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways.
J Exp Clin Cancer Res
2022
41(1):29
PubMed ID: 35063003
DOI: 10.1186/s13046-021-02167-3
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20575
Hassan G, Zahra MH, Seno A, Seno M.
The significance of ErbB2/3 in the conversion of induced pluripotent stem cells into cancer stem cells.
Sci Rep
2022
12(1):2711
PubMed ID: 35177646
DOI: 10.1038/s41598-022-04980-y
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20717
Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T.
Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.
PLoS One
2022
17(5)
PubMed ID: 35617311
DOI: 10.1371/journal.pone.0266620
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20864
Shichi Y, Gomi F, Ueda Y, Nonaka K, Hasegawa F, Hasegawa Y, Hinata N, Yoshimura H, Yamamoto M, Takahashi K, Arai T, Ishiwata T.
Multiple cystic sphere formation from PK-8 cells in three-dimensional culture.
Biochem Biophys Rep
2022
32:101339
PubMed ID: 36105614
DOI: 10.1016/j.bbrep.2022.101339
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20976
Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H.
Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.
Br J Cancer
2022
PubMed ID: 36536047
DOI: 10.1038/s41416-022-02106-9
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20074
Gomi F, Sasaki N, Shichi Y, Minami F, Shinji S, Toyoda M, Ishiwata T.
Polyvinyl alcohol increased growth, migration, invasion, and sphere size in the PK-8 pancreatic ductal adenocarcinoma cell line.
Heliyon
2021
7(2):e06182
PubMed ID: 33598581
DOI: 10.1016/j.heliyon.2021.e06182
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20090
Minami F, Sasaki N, Shichi Y, Gomi F, Michishita M, Ohkusu-Tsukada K, Toyoda M, Takahashi K, Ishiwata T.
Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures.
Sci Rep
2021
11(1):6775
PubMed ID: 33762591
DOI: 10.1038/s41598-021-86028-1
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20108
Tasaki Y, Suzuki M, Katsushima K, Shinjo K, Iijima K, Murofushi Y, Naiki-Ito A, Hayashi K, Qiu C, Takahashi A, Tanaka Y, Kawaguchi T, Sugawara M, Kataoka T, Naito M, Miyata K, Kataoka K, Noda T, Gao W, Kataoka H, Takahashi S, Kimura K, Kondo Y.
Cancer-Specific Targeting of Taurine-Upregulated Gene 1 Enhances the Effects of Chemotherapy in Pancreatic Cancer.
Cancer Res
2021
PubMed ID: 33648930
DOI: 10.1158/0008-5472.CAN-20-3021
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20247
Munekage E, Serada S, Tsujii S, Yokota K, Kiuchi K, Tominaga K, Fujimoto M, Kanda M, Uemura S, Namikawa T, Nomura T, Murakami I, Hanazaki K, Naka T.
A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.
Neoplasia
2021
23(9):939-950
PubMed ID: 34332450
DOI: 10.1016/j.neo.2021.07.006
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16124
Nakao Y, Nakagawa S, Yamashita YI, Umezaki N, Okamoto Y, Ogata Y, Yasuda-Yoshihara N, Itoyama R, Yusa T, Yamashita K, Miyata T, Okabe H, Hayashi H, Imai K, Baba H.
High ARHGEF2 (GEF-H1) Expression is Associated with Poor Prognosis Via Cell Cycle Regulation in Patients with Pancreatic Cancer
Ann Surg Oncol
2021
28(8):4733-4743
PubMed ID: 33393038
DOI: 10.1245/s10434-020-09383-9
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11820
Okazaki J, Tanahashi T, Sato Y, Miyoshi J, Nakagawa T, Kimura T, Miyamoto H, Fujino Y, Nakamura F, Takehara M, Ma B, Bando M, Kitamura S, Okamoto K, Muguruma N, Sogabe M, Takayama T.
MicroRNA-296-5p Promotes Cell Invasion and Drug Resistance by Targeting Bcl2-Related Ovarian Killer, Leading to a Poor Prognosis in Pancreatic Cancer.
Digestion
2020
101(6):794-806
PubMed ID: 31563901
DOI: 10.1159/000503225
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13240
Onodera T, Momose I, Adachi H, Yamazaki Y, Sawa R, Ohba SI, Kawada M.
Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition.
J Biol Chem
2020
PubMed ID: 32978257
DOI: 10.1074/jbc.RA120.013893
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13287
Sasaki N, Gomi F, Yoshimura H, Yamamoto M, Matsuda Y, Michishita M, Hatakeyama H, Kawano Y, Toyoda M, Korc M, Ishiwata T.
FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer.
Cancers (Basel)
2020
PubMed ID: 33066597
DOI: 10.3390/cancers12102976
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13542
Takehara M, Sato Y, Kimura T, Noda K, Miyamoto H, Fujino Y, Miyoshi J, Nakamura F, Wada H, Bando Y, Ikemoto T, Shimada M, Muguruma N, Takayama T.
Cancer-associated adipocytes promote pancreatic cancer progression through SAA1 expression
Cancer Sci
2020
111(8):2883-2894
PubMed ID: 32535957
DOI: 10.1111/cas.14527
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14280
Hobbs GA, Baker NM, Miermont AM, Thurman RD, Pierobon M, Tran TH, Anderson AO, Waters AM, Diehl JN, Papke B, Hodge RG, Klomp JE, Goodwin CM, DeLiberty JM, Wang J, Ng RWS, Gautam P, Bryant KL, Esposito D, Campbell SL, Petricoin EF 3rd, Simanshu DK, Aguirre AJ, Wolpin BM, Wennerberg K, Rudloff U, Cox AD, Der CJ.
Atypical KRAS G12R Mutant Is Impaired in PI3K Signaling and Macropinocytosis in Pancreatic Cancer
Cancer Discov
2020
10(1):104-123
PubMed ID: 31649109
DOI: 10.1158/2159-8290.CD-19-1006
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11218
Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T.
Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.
Oncogene
2019
38(8):1211-1224
PubMed ID: 30250298
DOI: 10.1038/s41388-018-0510-y
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5030
Tsukamoto M, Imai K, Ishimoto T, Komohara Y, Yamashita YI, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Miyata T, Arima K, Okabe H, Baba Y, Chikamoto A, Ishiko T, Hirota M, Baba H.
PD-L1 expression enhancement by infiltrating macrophage-derived tumor necrosis factor-α leads to poor pancreatic cancer prognosis.
Cancer Sci
2019
110(1):310-320
PubMed ID: 30426611
DOI: 10.1111/cas.13874
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11862
Afify SM, Chen L, Yan T, Calle AS, Nair N, Murakami C, Zahra MH, Okada N, Iwasaki Y, Seno A, Seno M.
Method to Convert Stem Cells into Cancer Stem Cells.
Methods Protoc
2019
PubMed ID: 31426391
DOI: 10.3390/mps2030071
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11960
Sasaki N, Hirabayashi K, Michishita M, Takahashi K, Hasegawa F, Gomi F, Itakura Y, Nakamura N, Toyoda M, Ishiwata T.
Ganglioside GM2, highly expressed in the MIA PaCa-2 pancreatic ductal adenocarcinoma cell line, is correlated with growth, invasion, and advanced stage.
Sci Rep
2019
PubMed ID: 31852956
DOI: 10.1038/s41598-019-55867-4
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12367
Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M.
Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts
Oncol Res
2019
27(8):945-956.
PubMed ID: 31046874
DOI: 10.3727/096504019X15555408784978
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12554
Takamatsu H, Yamamoto KI, Tomonobu N, Murata H, Inoue Y, Yamauchi A, Sumardika IW, Chen Y, Kinoshita R, Yamamura M, Fujiwara H, Mitsui Y, Araki K, Futami J, Saito K, Iioka H, Ruma IMW, Putranto EW, Nishibori M, Kondo E, Yamamoto Y, Toyooka S, Sakaguchi M.
Extracellular S100A11 Plays a Critical Role in Spread of the Fibroblast Population in Pancreatic Cancers
Oncol Res
2019
27(6):713-727
PubMed ID: 30850029
DOI: 10.3727/096504018X15433161908259
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14880
Momose I, Onodera T, Doi H, Adachi H, Iijima M, Yamazaki Y, Sawa R, Kubota Y, Igarashi M, Kawada M.
Leucinostatin Y: A Peptaibiotic Produced by the Entomoparasitic Fungus Purpureocillium lilacinum 40-H-28
J Nat Prod
2019
82(5):1120-1127
PubMed ID: 31017786
DOI: 10.1021/acs.jnatprod.8b00839
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10750
Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, Uchihara T, Ogata Y, Nakagawa S, Okabe H, Imai K, Hashimoto D, Chikamoto A, Yamashita YI, Baba H, Ishimoto T.
Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1β from activated macrophages leads to poor prognosis in pancreatic cancer.
Cancer Sci.
2018
109:462-470
PubMed ID: 29224225
DOI: 10.1111/cas.13467
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7044
Calle AS, Nair N, Oo AK, Prieto-Vila M, Koga M, Khayrani AC, Hussein M, Hurley L, Vaidyanath A, Seno A, Iwasaki Y, Calle M, Kasai T, Seno M.
A new PDAC mouse model originated from iPSCs-converted pancreatic cancer stem cells (CSCcm).
Am J Cancer Res
2016
6:2799-2815
PubMed ID: 28042501
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9938
Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S.
CASTIN: a system for comprehensive analysis of cancer-stromal interactome.
BMC Genomics
2016
17:899
PubMed ID: 27829362
DOI: 10.1186/s12864-016-3207-z
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12941
Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H, Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M.
Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells
Cancer Microenviron
2016
9(2-3):93-105
PubMed ID: 27334300
DOI: 10.1007/s12307-016-0185-2
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