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細胞番号 : 細胞名
RCB2630 : B16F10  update : 2021/11/29
細胞特性(Comment:英)Mouse cell line derived from melanoma. TKG0348 (Deposited from Tohoku Univ.).
細胞特性(日)マウスメラノーマ由来細胞株。 TKG0348 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Fukuda, Hiroshi
樹立者 Fidler, I. J.
寄託日 2007
元の細胞 TKG0348
動物種 _mouse < Mammals
動物系統名 C57BL/6J
採取組織 skin
病名 melanoma
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0348)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_0159
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
マウス系統検査 OK
アイソザイム検査 LD, NP
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 13件
Reference(日) 0件
利用者成果(英) 47件
利用者成果(日) 0件

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Reference(英)
5225  Fan D, Liaw A, Denkins YM, Collins JH, Van Arsdall M, Chang JL, Chakrabarty S, Nguyen D, Kruzel E, Fidler IJ.  Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma.  J Exp Ther Oncol  2002  2(5):286-97  PubMed ID: 12416032
5224  Dong Z, Yoneda J, Kumar R, Fidler IJ.  Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor.  J Exp Med  1998  188(4):755-63  PubMed ID: 9705957
5223  Esumi N, Fan D, Fidler IJ.  Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor.  Cancer Res  1991  51(17):4549-56  PubMed ID: 1873799
5221  Hart IR, Talmadge JE, Fidler IJ.  Comparative studies on the quantitative analysis of experimental metastatic capacity.  Cancer Res  1983  43(1):400-2  PubMed ID: 6291761
5220  Poste G, Doll J, Fidler IJ.  Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.  Proc Natl Acad Sci U S A  1981  78(10):6226-30  PubMed ID: 6947225
5217  Raz A, Bucana C, McLellan W, Fidler IJ.  Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential.  Nature  1980  284(5754):363-4  PubMed ID: 7360272
5218  Hart IR, Raz A, Fidler IJ.  Effect of cytoskeleton-disrupting agents on the metastatic behavior of melanoma cells.  J Natl Cancer Inst  1980  64(4):891-900  PubMed ID: 6929000
5219  Poste G, Doll J, Hart IR, Fidler IJ.  In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.  Cancer Res  1980  40(5):1636-44  PubMed ID: 7370995
5216  Fidler IJ, Nicolson GL.  Tumor cell and host properties affecting the implantation and survival of blood-borne metastatic variants of B16 melanoma.  Isr J Med Sci  1978  14(1):38-50  PubMed ID: 632082
5215  Fidler IJ, Bucana C.  Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes.  Cancer Res  1977  37(11):3945-56  PubMed ID: 908034
5213  Fidler IJ, Gersten DM, Budmen MB.  Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.  Cancer Res  1976  36(9 pt.1):3160-5  PubMed ID: 975082
5214  Fidler IJ, Nicolson GL.  Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines.  J Natl Cancer Inst  1976  57(5):1199-202  PubMed ID: 1003551
5212  Fidler IJ.  Biological behavior of malignant melanoma cells correlated to their survival in vivo.  Cancer Res  1975  35(1):218-24  PubMed ID: 1109790

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Reference(日)

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利用者成果(英)
13919  Kaneda-Nakashima K, Zhang Z, Manabe Y, Shimoyama A, Kabayama K, Watabe T, Kanai Y, Ooe K, Toyoshima A, Shirakami Y, Yoshimura T, Fukuda M, Hatazawa J, Nakano T, Fukase K, Shinohara A.  α-Emitting cancer therapy using 211 At-AAMT targeting LAT1  Cancer Sci  2021  112(3):1132-1140  PubMed ID: 33277750
20207  Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H.  Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles.  Arthritis Rheumatol  2021    PubMed ID: 34164946
20230  Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M.  Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.  Cell Death Dis  2021  12(7):698  PubMed ID: 34257282
15168  Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T.  Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells  Nat Immunol  2021  22(8):947-957  PubMed ID: 34239121
20277  Zhou S, Yotsumoto H, Tian Y, Sakamoto K.  α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway.  Biochem Biophys Rep  2021  26:100949  PubMed ID: 33665379
15279  Maeda M, Suzuki M, Takashima S, Sasaki T, Oh-Hashi K, Takemori H.  The new live imagers MitoMM1/2 for mitochondrial visualization  Biochem Biophys Res Commun  2021  562:50-54  PubMed ID: 34034093
20323  Mori D, Tsujikawa T, Sugiyama Y, Kotani SI, Fuse S, Ohmura G, Arai A, Kawaguchi T, Hirano S, Mazda O, Kishida T.  Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors.  Int J Cancer  2021    PubMed ID: 34460096
20331  Maeda M, Suzuki M, Fuchino H, Tanaka N, Kobayashi T, Isogai R, Batubara I, Iswantini D, Matsuno M, Kawahara N, Koketsu M, Hamamoto A, Takemori H.  Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan.  J Nat Med  2021    PubMed ID: 34510371
20370  Jo JI, Emi T, Tabata Y.  Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect.  Pharmaceutics  2021  13(10)  PubMed ID: 34684017
15709  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.  Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis  J Clin Invest   2021  131(17):e139933  PubMed ID: 34623325
11949  Kozaka S, Tahara Y, Wakabayashi R, Nakata T, Ueda T, Kamiya N, Goto M.  Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier.  Mol. Pharm.  2020    PubMed ID: 31833775
12095  Baba K, Nomura M, Ohashi S, Hiratsuka T, Nakai Y, Saito T, Kondo Y, Fukuyama K, Kikuchi O, Yamada A, Matsubara J, Hirohashi K, Mitani Y, Mizumoto A, Muto M.  Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.  Am J Cancer Res  2020    PubMed ID: 32195019
12122  Makbal R, Villareal MO, Gadhi C, Hafidi A, Isoda H.  Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation.  Int J Mol Sci  2020    PubMed ID: 32268492
12174  Myra O. Villareal, Thanyanan Chaochaiphat, Meriem Bejaoui, Kozo Sato, Hiroko Isoda  Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression  Planta Medica International Open  2020   
12201  Irmanida Batubara, Rika Indri Astuti, Muhammad Eka Prastya, Auliya Ilmiawati, Miwa Maeda, Mayu Suzuki, Akie Hamamoto, Hiroshi Takemori  The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level  Antioxidants (Basel)  2020  9(8):719  PubMed ID: 32784463
13040  Li K, Sun S, Kageyama M, Xiao L, Xing G, Gao R, You F, Fu X, Zhang Z.  Evaluation of the Immunomodulatory and Anti-Inflammatory Activities of Honey Bee Larva Powder.  J Med Food  2020    PubMed ID: 32456573
13388  Zhou S, Sakamoto K.  Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway.  PLoS One  2020    PubMed ID: 33332393
13500  Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, Sato H.  Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice  Int J Cancer  2020  147(11):3224-3235  PubMed ID: 32818320
13558  Bejaoui M, Villareal MO, Isoda H.  3,4,5-Tri- O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes  Front Cell Dev Biol  2020  8:175.  PubMed ID: 32269993
14503  The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays  The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays  Foods  2020  9(1):73  PubMed ID: 31936516
11294  Zhou S, Sakamoto K.  Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways.  Genes Cells  2019    PubMed ID: 30417494
11549  Chowdhury MR, Moshikur RM, Wakabayashi R, Tahara Y, Kamiya N, Moniruzzaman M, Goto M.  In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations.  Int J Pharm  2019    PubMed ID: 31077761
11612  Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.  Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.  Genes Cells  2019    PubMed ID: 31234244
11645  Yamada H, Hakozaki M, Uemura A, Yamashita T.  Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells.  J. Lipid Res.  2019    PubMed ID: 31345992
11698  Kazuomi Sato, Yuji Yamaguchi, Setsuko Sakaki, Hiroyuki Takenaka   Pleurochrysis carterae Hot-Water Extract Inhibits Melanogenesis in Murine Melanoma Cells  Cosmetics  2019   
11795  Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A.  Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells.  Genes Cells  2019    PubMed ID: 31495058
11828  Morikura T, Miyata S.  Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device.  Micromachines (Basel)  2019    PubMed ID: 31575066
4074  Kazue Mizuno et al  Plasma-Induced Suppression of Recurrent and Reinoculated Melanoma Tumors in Mice  IEEE Transactions on Radiation and Plasma Medical Sciences  2018  2:353 - 359 
4151  Manome Y, Suzuki D, Mochizuki A, Saito E, Sasa K, Yoshimura K, Inoue T, Takami M, Inagaki K, Funatsu T, Kamijo R.  The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages.  Oncotarget  2018    PubMed ID: 30042824
4158  Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A.  Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice.  Cancer Chemother. Pharmacol.  2018    PubMed ID: 29869202
4470  Villareal MO, Sato Y, Matsuyama K, Isoda H.  Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo.  BMC Cancer  2018  18(1):856  PubMed ID: 30157785
14897  Wakabayashi R, Sakuragi M, Kozaka S, Tahara Y, Kamiya N, Goto M.  Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma  Mol Pharm  2018  15(3):955-961  PubMed ID: 29397746
10617  Villareal MO, Kume S, Neffati M, Isoda H.  Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes.  Biomed Res Int  2017  2017:8303671  PubMed ID: 29359158
4527  Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Yoshikazu Yonei  Inhibition of AGE-induced Melanogenesis in B16 Melanoma Cells by Iridoid-containing Plants  Glycative Stress Research  2017  4 (1): 067-070 
13481  Gunarta IK, Li R, Nakazato R, Suzuki R, Boldbaatar J, Suzuki T, Yoshioka K.  Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells  Cancer Sci  2017  108(8):1602-1611  PubMed ID: 28635133
14635  Sato K, Takei M, Iyota R, Muraoka Y, Nagashima M, Yoshimura Y.  Indomethacin inhibits melanogenesis via down-regulation of Mitf mRNA transcription  Biosci Biotechnol Biochem  2017  81(12):2307-2313  PubMed ID: 29090638
14722  Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.  Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages  Proc Natl Acad Sci U S A  2017  114(35):E7331-E7340  PubMed ID: 28808017
10866    Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor  Journal of Drug Delivery Science and Technology  2016  33, 143-148 
10926  Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Shoichi Yamagishi, Yoshikazu Yonei  Melanin synthesis induction by advanced glycation end-products (AGEs) without α-melanocyte stimulating hormone (α-MSH) or UV exposure   Glycative Stress Research  2016  3 : 229-235 
12625  Nishio T, Usami M, Awaji M, Shinohara S, Sato K.  Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis  Mol Cell Biochem  2016  412(1-2):101-10  PubMed ID: 26699907
12841  Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ.  Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells  Oncotarget  2016  7(31):48860-48869.  PubMed ID: 27384490
14583  Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N.  Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease  Lab Invest  2016  96(4):468-80  PubMed ID: 26808709
7375  Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY.  Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.  Int J Mol Sci  2015  16:8772-88  PubMed ID: 25903150
5420  Katoh D, Nishizuka M1, Osada S1, Imagawa M1.  Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity.  PLoS One  2015  10(2):e0117197  PubMed ID: 25671570
15155  Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.  TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN  Eur J Immunol  2015  45(4):1159-69  PubMed ID: 25529558
13480  Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells  Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells  J Vet Med Sci  2012  74(5):545-51  PubMed ID: 22146339
13691  Ryuya Yamanaka, Susan A. Zullo, Ryuichi Tanaka, Michael Blaese, Kleanthis G. Xanthopoulos  Enhancement of antitumor immune response in glioma models in mice by genetically modified dendritic cells pulsed with Semliki Forest virus—mediated complementary DNA  Journal of Neurosurgery  2001  94:474-481 

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