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Cell No. : Cell Name
RCB2630 : B16F10  update : 2023/02/09
CommentMouse cell line derived from melanoma. TKG0348 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Fukuda, Hiroshi
Originator Fidler, I. J.
Year of deposit 2007
Original cell TKG0348
Animal mouse < Mammals
Strain name C57BL/6J
Tissue skin
Disease name melanoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0348)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0159
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 10-20 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
SSLP(mouse) OK
deposit info
lot info
Reference information Reference 13
User's Publication 58

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5225  Fan D, Liaw A, Denkins YM, Collins JH, Van Arsdall M, Chang JL, Chakrabarty S, Nguyen D, Kruzel E, Fidler IJ.  Type-1 transforming growth factor-beta differentially modulates tumoricidal activity of murine peritoneal macrophages against metastatic variants of the B16 murine melanoma.  J Exp Ther Oncol  2002  2(5):286-97  PubMed ID: 12416032   DOI: 10.1046/j.1359-4117.2002.01053.x
5224  Dong Z, Yoneda J, Kumar R, Fidler IJ.  Angiostatin-mediated suppression of cancer metastases by primary neoplasms engineered to produce granulocyte/macrophage colony-stimulating factor.  J Exp Med  1998  188(4):755-63  PubMed ID: 9705957   DOI: 10.1084/jem.188.4.755
5223  Esumi N, Fan D, Fidler IJ.  Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor.  Cancer Res  1991  51(17):4549-56  PubMed ID: 1873799  
5221  Hart IR, Talmadge JE, Fidler IJ.  Comparative studies on the quantitative analysis of experimental metastatic capacity.  Cancer Res  1983  43(1):400-2  PubMed ID: 6291761  
5220  Poste G, Doll J, Fidler IJ.  Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells.  Proc Natl Acad Sci U S A  1981  78(10):6226-30  PubMed ID: 6947225   DOI: 10.1073/pnas.78.10.6226
5217  Raz A, Bucana C, McLellan W, Fidler IJ.  Distribution of membrane anionic sites on B16 melanoma variants with differing lung colonising potential.  Nature  1980  284(5754):363-4  PubMed ID: 7360272   DOI: 10.1038/284363a0
5218  Hart IR, Raz A, Fidler IJ.  Effect of cytoskeleton-disrupting agents on the metastatic behavior of melanoma cells.  J Natl Cancer Inst  1980  64(4):891-900  PubMed ID: 6929000  
5219  Poste G, Doll J, Hart IR, Fidler IJ.  In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.  Cancer Res  1980  40(5):1636-44  PubMed ID: 7370995  
5216  Fidler IJ, Nicolson GL.  Tumor cell and host properties affecting the implantation and survival of blood-borne metastatic variants of B16 melanoma.  Isr J Med Sci  1978  14(1):38-50  PubMed ID: 632082  
5215  Fidler IJ, Bucana C.  Mechanism of tumor cell resistance to lysis by syngeneic lymphocytes.  Cancer Res  1977  37(11):3945-56  PubMed ID: 908034  
5213  Fidler IJ, Gersten DM, Budmen MB.  Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity.  Cancer Res  1976  36(9 pt.1):3160-5  PubMed ID: 975082  
5214  Fidler IJ, Nicolson GL.  Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines.  J Natl Cancer Inst  1976  57(5):1199-202  PubMed ID: 1003551   DOI: 10.1093/jnci/57.5.1199
5212  Fidler IJ.  Biological behavior of malignant melanoma cells correlated to their survival in vivo.  Cancer Res  1975  35(1):218-24  PubMed ID: 1109790  

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User's Publication
21052  Zhou S, Yamada R, Sakamoto K.  Low energy multiple blue light-emitting diode light Irradiation promotes melanin synthesis and induces DNA damage in B16F10 melanoma cells.  PLoS One  2023  18(2):e0281062  PubMed ID: 36730244   DOI: 10.1371/journal.pone.0281062
21056  Chen P, Yang W, Nagaoka K, Huang GL, Miyazaki T, Hong T, Li S, Igarashi K, Takeda K, Kakimi K, Kataoka K, Cabral H.  An IL-12-Based Nanocytokine Safely Potentiates Anticancer Immunity through Spatiotemporal Control of Inflammation to Eradicate Advanced Cold Tumors.  Adv Sci (Weinh)  2023  e2205139  PubMed ID: 36739605   DOI: 10.1002/advs.202205139
20207  Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H.  Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles.  Arthritis Rheumatol  2022    PubMed ID: 34164946   DOI: 10.1002/art.41897
20331  Maeda M, Suzuki M, Fuchino H, Tanaka N, Kobayashi T, Isogai R, Batubara I, Iswantini D, Matsuno M, Kawahara N, Koketsu M, Hamamoto A, Takemori H.  Diversity of Adenostemma lavenia, multi-potential herbs, and its kaurenoic acid composition between Japan and Taiwan.  J Nat Med  2022    PubMed ID: 34510371   DOI: 10.1007/s11418-021-01565-3
20712  Kondo N, Hirano F, Temma T.  Evaluation of 3-Borono-l-Phenylalanine as a Water-Soluble Boron Neutron Capture Therapy Agent.  Pharmaceutics  2022  14(5)  PubMed ID: 35631692   DOI: 10.3390/pharmaceutics14051106
20781  Uesugi S, Hakozaki M, Kanno Y, Takahashi Y, Shindo K, Kimura KI, Yano A.  Anti-melanogenic effect of furanoeremophilanes identified from edible wild plants belonging to the genus Cacalia.  Biosci Biotechnol Biochem  2022    PubMed ID: 35867866   DOI: 10.1093/bbb/zbac124
13919  Kaneda-Nakashima K, Zhang Z, Manabe Y, Shimoyama A, Kabayama K, Watabe T, Kanai Y, Ooe K, Toyoshima A, Shirakami Y, Yoshimura T, Fukuda M, Hatazawa J, Nakano T, Fukase K, Shinohara A.  α-Emitting cancer therapy using 211 At-AAMT targeting LAT1  Cancer Sci  2021  112(3):1132-1140  PubMed ID: 33277750   DOI: 10.1111/cas.14761
20230  Zheng J, Sato M, Mishima E, Sato H, Proneth B, Conrad M.  Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines.  Cell Death Dis  2021  12(7):698  PubMed ID: 34257282   DOI: 10.1038/s41419-021-03998-w
15168  Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T.  Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells  Nat Immunol  2021  22(8):947-957  PubMed ID: 34239121   DOI: 10.1038/s41590-021-00967-5
20277  Zhou S, Yotsumoto H, Tian Y, Sakamoto K.  α-Mangostin suppressed melanogenesis in B16F10 murine melanoma cells through GSK3β and ERK signaling pathway.  Biochem Biophys Rep  2021  26:100949  PubMed ID: 33665379   DOI: 10.1016/j.bbrep.2021.100949
15279  Maeda M, Suzuki M, Takashima S, Sasaki T, Oh-Hashi K, Takemori H.  The new live imagers MitoMM1/2 for mitochondrial visualization  Biochem Biophys Res Commun  2021  562:50-54  PubMed ID: 34034093   DOI: 10.1016/j.bbrc.2021.05.040
20323  Mori D, Tsujikawa T, Sugiyama Y, Kotani SI, Fuse S, Ohmura G, Arai A, Kawaguchi T, Hirano S, Mazda O, Kishida T.  Extracellular acidity in tumor tissue upregulates PD-L1 expression on tumor cells via proton-sensing G protein-coupled receptors.  Int J Cancer  2021    PubMed ID: 34460096   DOI: 10.1002/ijc.33786
20370  Jo JI, Emi T, Tabata Y.  Design of a Platelet-Mediated Delivery System for Drug-Incorporated Nanospheres to Enhance Anti-Tumor Therapeutic Effect.  Pharmaceutics  2021  13(10)  PubMed ID: 34684017   DOI: 10.3390/pharmaceutics13101724
15709  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.  Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis  J Clin Invest   2021  131(17):e139933  PubMed ID: 34623325   DOI: 10.1172/JCI139933
16045  Fardous J, Omoso Y, Joshi A, Yoshida K, Patwary MKA, Ono F, Ijima H.  Development and characterization of gel-in-water nanoemulsion as a novel drug delivery system  Mater Sci Eng C Mater Biol Appl  2021  124:112076  PubMed ID: 33947568   DOI: 10.1016/j.msec.2021.112076
16057  Morikura T, Miyata S.  Mechanical Intermittent Compression Affects the Progression Rate of Malignant Melanoma Cells in a Cycle Period-Dependent Manner  Diagnostics (Basel)  2021  11(6):1112  PubMed ID: 34207144   DOI: 10.3390/diagnostics11061112
16127  Kobayashi M, Kojima K, Murayama K, Amano Y, Koyama T, Ogama N, Takeshita T, Fukuhara T, Tanaka N.  MK-6, a novel not-α IL-2, elicits a potent antitumor activity by improving the effector to regulatory T cell balance  Cancer Sci   2021  112(11):4478-4489  PubMed ID: 34545658   DOI: 10.1111/cas.15127
16276  Shibuya T, Kamiyama A, Sawada H, Kikuchi K, Maruyama M, Sawado R, Ikeda N, Asano K, Kurotaki D, Tamura T, Yoneda A, Imada K, Satoh T, Akira S, Tanaka M, Yotsumoto S.  Immunoregulatory Monocyte Subset Promotes Metastasis Associated With Therapeutic Intervention for Primary Tumor  Front Immunol  2021  12:663115  PubMed ID: 34163472   DOI: 10.3389/fimmu.2021.663115
16871  Myra O. Villareal, Meriem Bejaoui, Thanyanan Chaochaiphat, Kozo Sato, Hiroko Isoda  Tara (Caesalpinia spinosa L.) tannin promotes proliferation and expression of hair growth-associated markers in human follicular dermal papilla cells  Euro-Mediterranean Journal for Environmental Integration  2021  6    DOI: 10.1007/s41207-021-00273-4
17028  Moshikur RM, Ali MK, Wakabayashi R, Moniruzzaman M, Goto M.  Methotrexate-based ionic liquid as a potent anticancer drug for oral delivery: In vivo pharmacokinetics, biodistribution, and antitumor efficacy  Int J Pharm  2021  608:121129  PubMed ID: 34562557   DOI: 10.1016/j.ijpharm.2021.121129
11949  Kozaka S, Tahara Y, Wakabayashi R, Nakata T, Ueda T, Kamiya N, Goto M.  Transcutaneous Cancer Vaccine Using a Reverse Micellar Antigen Carrier.  Mol. Pharm.  2020    PubMed ID: 31833775   DOI: 10.1021/acs.molpharmaceut.9b01104
12095  Baba K, Nomura M, Ohashi S, Hiratsuka T, Nakai Y, Saito T, Kondo Y, Fukuyama K, Kikuchi O, Yamada A, Matsubara J, Hirohashi K, Mitani Y, Mizumoto A, Muto M.  Experimental model for the irradiation-mediated abscopal effect and factors influencing this effect.  Am J Cancer Res  2020    PubMed ID: 32195019  
12122  Makbal R, Villareal MO, Gadhi C, Hafidi A, Isoda H.  Argania Spinosa Fruit Shell Extract-Induced Melanogenesis via cAMP Signaling Pathway Activation.  Int J Mol Sci  2020    PubMed ID: 32268492   DOI: 10.3390/ijms21072539
12174  Myra O. Villareal, Thanyanan Chaochaiphat, Meriem Bejaoui, Kozo Sato, Hiroko Isoda  Tara Tannin Regulates Pigmentation by Modulating Melanogenesis Enzymes and Melanosome Transport Proteins Expression  Planta Medica International Open  2020      DOI: 10.1055/a-1141-0151
12201  Irmanida Batubara, Rika Indri Astuti, Muhammad Eka Prastya, Auliya Ilmiawati, Miwa Maeda, Mayu Suzuki, Akie Hamamoto, Hiroshi Takemori  The Antiaging Effect of Active Fractions and Ent-11α-Hydroxy-15-Oxo-Kaur-16-En-19-Oic Acid Isolated from Adenostemma lavenia (L.) O. Kuntze at the Cellular Level  Antioxidants (Basel)  2020  9(8):719  PubMed ID: 32784463   DOI: 10.3390/antiox9080719
13040  Li K, Sun S, Kageyama M, Xiao L, Xing G, Gao R, You F, Fu X, Zhang Z.  Evaluation of the Immunomodulatory and Anti-Inflammatory Activities of Honey Bee Larva Powder.  J Med Food  2020    PubMed ID: 32456573   DOI: 10.1089/jmf.2019.4554
13388  Zhou S, Sakamoto K.  Citric acid promoted melanin synthesis in B16F10 mouse melanoma cells, but inhibited it in human epidermal melanocytes and HMV-II melanoma cells via the GSK3β/β-catenin signaling pathway.  PLoS One  2020    PubMed ID: 33332393   DOI: 10.1371/journal.pone.0243565
13500  Sato M, Onuma K, Domon M, Hasegawa S, Suzuki A, Kusumi R, Hino R, Kakihara N, Kanda Y, Osaki M, Hamada J, Bannai S, Feederle R, Buday K, Angeli JPF, Proneth B, Conrad M, Okada F, Sato H.  Loss of the cystine/glutamate antiporter in melanoma abrogates tumor metastasis and markedly increases survival rates of mice  Int J Cancer  2020  147(11):3224-3235  PubMed ID: 32818320   DOI: 10.1002/ijc.33262
13558  Bejaoui M, Villareal MO, Isoda H.  3,4,5-Tri- O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes  Front Cell Dev Biol  2020  8:175.  PubMed ID: 32269993   DOI: 10.3389/fcell.2020.00175
14503  The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays  The High Content of Ent- 11α-hydroxy-15-oxo-kaur- 16-en-19-oic Acid in Adenostemma lavenia (L.) O. Kuntze Leaf Extract: With Preliminary in Vivo Assays  Foods  2020  9(1):73  PubMed ID: 31936516   DOI: 10.3390/foods9010073
11294  Zhou S, Sakamoto K.  Pyruvic acid/ethyl pyruvate inhibits melanogenesis in B16F10 melanoma cells through PI3K/AKT, GSK3β, and ROS-ERK signaling pathways.  Genes Cells  2019    PubMed ID: 30417494   DOI: 10.1111/gtc.12654
11549  Chowdhury MR, Moshikur RM, Wakabayashi R, Tahara Y, Kamiya N, Moniruzzaman M, Goto M.  In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations.  Int J Pharm  2019    PubMed ID: 31077761   DOI: 10.1016/j.ijpharm.2019.05.020
11612  Sugiyama Y, Shudo T, Hosokawa S, Watanabe A, Nakano M, Kakizuka A.  Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.  Genes Cells  2019    PubMed ID: 31234244   DOI: 10.1111/gtc.12712
11645  Yamada H, Hakozaki M, Uemura A, Yamashita T.  Effect of fatty acids on melanogenesis and tumor cell growth in melanoma cells.  J. Lipid Res.  2019    PubMed ID: 31345992   DOI: 10.1194/jlr.M090712
11698  Kazuomi Sato, Yuji Yamaguchi, Setsuko Sakaki, Hiroyuki Takenaka   Pleurochrysis carterae Hot-Water Extract Inhibits Melanogenesis in Murine Melanoma Cells  Cosmetics  2019      DOI: 10.3390/cosmetics6040060
11795  Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A.  Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells.  Genes Cells  2019    PubMed ID: 31495058   DOI: 10.1111/gtc.12719
11828  Morikura T, Miyata S.  Effect of Mechanical Compression on Invasion Process of Malignant Melanoma Using In Vitro Three-Dimensional Cell Culture Device.  Micromachines (Basel)  2019    PubMed ID: 31575066   DOI: 10.3390/mi10100666
4074  Kazue Mizuno et al  Plasma-Induced Suppression of Recurrent and Reinoculated Melanoma Tumors in Mice  IEEE Transactions on Radiation and Plasma Medical Sciences  2018  2:353 - 359    DOI: 10.1109/TRPMS.2018.2809673
4151  Manome Y, Suzuki D, Mochizuki A, Saito E, Sasa K, Yoshimura K, Inoue T, Takami M, Inagaki K, Funatsu T, Kamijo R.  The inhibition of malignant melanoma cell invasion of bone by the TLR7 agonist R848 is dependent upon pro-inflammatory cytokines produced by bone marrow macrophages.  Oncotarget  2018    PubMed ID: 30042824   DOI: 10.18632/oncotarget.25711
4158  Shimada K, Ushijima K, Suzuki C, Horiguchi M, Ando H, Akita T, Shimamura M, Fujii J, Yamashita C, Fujimura A.  Pulmonary administration of curcumin inhibits B16F10 melanoma lung metastasis and invasion in mice.  Cancer Chemother. Pharmacol.  2018    PubMed ID: 29869202   DOI: 10.1007/s00280-018-3616-6
4470  Villareal MO, Sato Y, Matsuyama K, Isoda H.  Daphnane diterpenes inhibit the metastatic potential of B16F10 murine melanoma cells in vitro and in vivo.  BMC Cancer  2018  18(1):856  PubMed ID: 30157785   DOI: 10.1186/s12885-018-4693-y
14897  Wakabayashi R, Sakuragi M, Kozaka S, Tahara Y, Kamiya N, Goto M.  Solid-in-Oil Peptide Nanocarriers for Transcutaneous Cancer Vaccine Delivery against Melanoma  Mol Pharm  2018  15(3):955-961  PubMed ID: 29397746   DOI: 10.1021/acs.molpharmaceut.7b00894
10617  Villareal MO, Kume S, Neffati M, Isoda H.  Upregulation of Mitf by Phenolic Compounds-Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal Melanocytes.  Biomed Res Int  2017  2017:8303671  PubMed ID: 29359158   DOI: 10.1155/2017/8303671
4527  Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Yoshikazu Yonei  Inhibition of AGE-induced Melanogenesis in B16 Melanoma Cells by Iridoid-containing Plants  Glycative Stress Research  2017  4 (1): 067-070    DOI: 10.24659/gsr.4.1_067
13481  Gunarta IK, Li R, Nakazato R, Suzuki R, Boldbaatar J, Suzuki T, Yoshioka K.  Critical role of glioma-associated oncogene homolog 1 in maintaining invasive and mesenchymal-like properties of melanoma cells  Cancer Sci  2017  108(8):1602-1611  PubMed ID: 28635133   DOI: 10.1111/cas.13294
14635  Sato K, Takei M, Iyota R, Muraoka Y, Nagashima M, Yoshimura Y.  Indomethacin inhibits melanogenesis via down-regulation of Mitf mRNA transcription  Biosci Biotechnol Biochem  2017  81(12):2307-2313  PubMed ID: 29090638   DOI: 10.1080/09168451.2017.1394812
14722  Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S.  Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages  Proc Natl Acad Sci U S A  2017  114(35):E7331-E7340  PubMed ID: 28808017   DOI: 10.1073/pnas.1708598114
10866    Tumor distribution and anti-tumor effect of doxorubicin following intrapulmonary administration to mice with metastatic lung tumor  Journal of Drug Delivery Science and Technology  2016  33, 143-148    DOI: 10.1016/j.jddst.2016.04.001
10926  Yumi Abe, Wakako Takabe, Masayuki Yagi, Akemi Uwaya, Fumiyuki Isami, Shoichi Yamagishi, Yoshikazu Yonei  Melanin synthesis induction by advanced glycation end-products (AGEs) without α-melanocyte stimulating hormone (α-MSH) or UV exposure   Glycative Stress Research  2016  3 : 229-235    DOI: 10.24659/gsr.3.4_229
12625  Nishio T, Usami M, Awaji M, Shinohara S, Sato K.  Dual effects of acetylsalicylic acid on ERK signaling and Mitf transcription lead to inhibition of melanogenesis  Mol Cell Biochem  2016  412(1-2):101-10  PubMed ID: 26699907   DOI: 10.1007/s11010-015-2613-x
12841  Kitahata Y, Kanuma T, Hayashi M, Kobayashi N, Ozasa K, Kusakabe T, Temizoz B, Kuroda E, Yamaue H, Coban C, Yamamoto T, Kobiyama K, Aoshi T, Ishii KJ.  Circulating nano-particulate TLR9 agonist scouts out tumor microenvironment to release immunogenic dead tumor cells  Oncotarget  2016  7(31):48860-48869.  PubMed ID: 27384490   DOI: 10.18632/oncotarget.10379
14583  Kondo T, Tsunematsu T, Yamada A, Arakaki R, Saito M, Otsuka K, Kujiraoka S, Ushio A, Kurosawa M, Kudo Y, Ishimaru N.  Acceleration of tumor growth due to dysfunction in M1 macrophages and enhanced angiogenesis in an animal model of autoimmune disease  Lab Invest  2016  96(4):468-80  PubMed ID: 26808709   DOI: 10.1038/labinvest.2015.166
7375  Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY.  Melanogenesis-inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression.  Int J Mol Sci  2015  16:8772-88  PubMed ID: 25903150   DOI: 10.3390/ijms16048772
5420  Katoh D, Nishizuka M1, Osada S1, Imagawa M1.  Fad104, a positive regulator of adipocyte differentiation, suppresses invasion and metastasis of melanoma cells by inhibition of STAT3 activity.  PLoS One  2015  10(2):e0117197  PubMed ID: 25671570   DOI: 10.1371/journal.pone.0117197
15155  Temizoz B, Kuroda E, Ohata K, Jounai N, Ozasa K, Kobiyama K, Aoshi T, Ishii KJ.  TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN  Eur J Immunol  2015  45(4):1159-69  PubMed ID: 25529558   DOI: 10.1002/eji.201445132
17093  Fujiwara S, Nagai H, Shimoura N, Oniki S, Yoshimoto T, Nishigori C.  Intratumoral CD4+ T lymphodepletion sensitizes poorly immunogenic melanomas to immunotherapy with an OX40 agonist  J Invest Dermatol  2014  134(7):1884-1892  PubMed ID: 24468748   DOI: 10.1038/jid.2014.42
17122  Ichikawa H, Uneme T, Andoh T, Arita Y, Fujimoto T, Suzuki M, Sakurai Y, Shinto H, Fukasawa T, Fujii F, Fukumori Y.  Gadolinium-loaded chitosan nanoparticles for neutron-capture therapy: Influence of micrometric properties of the nanoparticles on tumor-killing effect  Appl Radiat Isot  2014  88:109-13  PubMed ID: 24462286   DOI: 10.1016/j.apradiso.2013.12.018
13480  Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells  Photodynamic hyperthermal therapy with indocyanine green (ICG) induces apoptosis and cell cycle arrest in B16F10 murine melanoma cells  J Vet Med Sci  2012  74(5):545-51  PubMed ID: 22146339   DOI: 10.1292/jvms.11-0464

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