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21995
Jiang M, Zhao D, Zhou Y, Kong W, Xie Z, Xiong Y, Li Y, Zhao S, Kou X, Zhang S, Meng R, Pan Y, Wu Z, Nakanishi H, Zhao J, Li H, Quan Z, Lin L, Qing H, Ni J.
Cathepsin B modulates microglial migration and phagocytosis of amyloid β in Alzheimer's disease through PI3K-Akt signaling.
Neuropsychopharmacology
2024
PubMed ID: 39304744
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22006
Yeh TY, Chu WJ, Huang YS.
GM1 ganglioside protects against LPS-induced neuroinflammatory and oxidative responses by inhibiting the activation of Akt, TAK1 and NADPH oxidase in MG6 microglial cells
Glycobiology
2024
34(1):cwad087
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DOI: 10.1093/glycob/cwad087
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22161
Lee JW, Mizuno K, Watanabe H, Lee IH, Tsumita T, Hida K, Yawaka Y, Kitagawa Y, Hasebe A, Iimura T, Kong SW.
Enhanced phagocytosis associated with multinucleated microglia via Pyk2 inhibition in an acute β-amyloid infusion model.
J Neuroinflammation
2024
21(1):196
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DOI: 10.1186/s12974-024-03192-7
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19625
Mutoh T, Kikuchi H, Jitsuishi T, Kitajo K, Yamaguchi A.
Spatiotemporal expression patterns of ZBP1 in the brain of mouse experimental stroke model
J Chem Neuroanat
2023
134:102362
PubMed ID: 37952561
DOI: 10.1016/j.jchemneu.2023.102362
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19626
Kong W, Xie Z, Shang X, Hayashi Y, Lan F, Narengaowa, Zhao S, Li H, Quan Z, Wu Z, Nakanishi H, Qing H, Ni J.
Zinc finger protein 335 mediates lipopolysaccharide-induced neurodegeneration and memory loss as a transcriptional factor in microglia
Glia
2023
71(12):2720-2734
PubMed ID: 37522284
DOI: 10.1002/glia.24447
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21097
Fukasawa M, Nishio K, Oikawa D, Itou T, Iinuma T, Asano M.
Allograft inflammatory factor-1 released from the cerebral microglia affect several organs in the body.
J Mol Histol
2023
PubMed ID: 36877416
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21113
Sakai M, Yu Z, Taniguchi M, Picotin R, Oyama N, Stellwagen D, Ono C, Kikuchi Y, Matsui K, Nakanishi M, Yoshii H, Furuyashiki T, Abe T, Tomita H.
N-Acetylcysteine Suppresses Microglial Inflammation and Induces Mortality Dose-Dependently via Tumor Necrosis Factor-α Signaling.
Int J Mol Sci
2023
24(4)
PubMed ID: 36835209
DOI: 10.3390/ijms24043798
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21127
Kurniati D, Hirai S, Egashira Y.
Effect of apigenin on tryptophan metabolic key enzymes expression in lipopolysaccharide-induced microglial cells and its mechanism.
Heliyon
2023
9(1):e12743
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21298
Ishida T, Kawada K, Jobu K, Morisawa S, Kawazoe T, Nishimura S, Akagaki K, Yoshioka S, Miyamura M.
Exosome-like nanoparticles derived from Allium tuberosum prevent neuroinflammation in microglia-like cells.
J Pharm Pharmacol
2023
PubMed ID: 37390476
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21300
Akaishi T, Yamamoto S, Abe K.
3',4'-Dihydroxyflavonol Attenuates Lipopolysaccharide-Induced Neuroinflammatory Responses of Microglial Cells by Suppressing AKT-mTOR and NF-κB Pathways.
Biol Pharm Bull
2023
46(7):914-920
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Komori T, Kuwahara T, Fujimoto T, Sakurai M, Koyama-Honda I, Fukuda M, Iwatsubo T.
Phosphorylation of Rab29 at Ser185 regulates its localization and role in the lysosomal stress response in concert with LRRK2.
J Cell Sci
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17649
Inoue E, Minatozaki S, Katsuta Y, Nonaka S, Nakanishi H.
Human β-Defensin 3 Inhibits Porphyromonas Gingivalis Lipopolysaccharide-Induced Oxidative and Inflammatory Responses of Microglia by Suppression of Cathepsins B and L
Int J Mol Sci
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20396
Liu Y, Li H, Hu J, Wu Z, Meng J, Hayashi Y, Nakanishi H, Qing H, Ni J.
Differential Expression and Distinct Roles of Proteinase-Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia-Ischemic Injury.
Mol Neurobiol
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20546
Tana, Nakagawa T.
Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease.
Biochem Biophys Res Commun
2022
588:168-174
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Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J.
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease.
Aging Cell
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3',4',7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway.
Biol Pharm Bull
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20685
Maejima Y, Horita S, Yokota S, Yamachi M, Shimizu M, Ono T, Yu Z, Tomita H, Shimomura K.
Surface translocation of Kir2.1 channel induces IL-1β secretion in microglia.
Mol Cell Neurosci
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20786
Kawamura N, Katsuura G, Yamada-Goto N, Nakama R, Kambe Y, Miyata A, Furuyashiki T, Narumiya S, Ogawa Y, Inui A.
Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice.
Sci Rep
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Brain
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J Neuroinflammation
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Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.
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11(1):13471
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16425
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Heliyon
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Saputra WD, Shono H, Ohsaki Y, Sultana H, Komai M, Shirakawa H.
Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation
Int J Mol Sci
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Jiang M, Zhang X, Yan X, Mizutani S, Kashiwazaki H, Ni J, Wu Z.
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Brain Behav Immun
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Biochem. Biophys. Res. Commun.
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Neurobiol Aging
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Mar Drugs
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Carcinogenesis
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Ni J, Wu Z, Stoka V, Meng J, Hayashi Y, Peters C, Qing H, Turk V, Nakanishi H.
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
Aging Cell
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Cell Calcium
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Int J Mol Sci
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Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Cells
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Youssef M, Ibrahim A, Akashi K, Hossain MS.
PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells.
Neuroscience
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Fujikura M1, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.
J Alzheimers Dis
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Front Pharmacol
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Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson's disease model.
Sci Rep
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J Neuroinflammation
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Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Disease Treatment
ACS Biomater Sci Eng
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EMBO Mol Med
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The Critical Role of IL-10 in the Anti-neuroinflammatory and Anti-oxidative Effects of Rheum tanguticum on Activated Microglia
Oxid Med Cell Longev
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Sci Rep
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Ratanasampil Suppresses the Hypoxia-Related Inflammatory Responses by Inhibiting Oxidative Stress and NF-kB Activation in Microglia
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