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20396
Liu Y, Li H, Hu J, Wu Z, Meng J, Hayashi Y, Nakanishi H, Qing H, Ni J.
Differential Expression and Distinct Roles of Proteinase-Activated Receptor 2 in Microglia and Neurons in Neonatal Mouse Brain After Hypoxia-Ischemic Injury.
Mol Neurobiol
2022
PubMed ID: 34762231
DOI: 10.1007/s12035-021-02594-5
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20546
Tana, Nakagawa T.
Luteolin ameliorates depression-like behaviors by suppressing ER stress in a mouse model of Alzheimer's disease.
Biochem Biophys Res Commun
2022
588:168-174
PubMed ID: 34959189
DOI: 10.1016/j.bbrc.2021.12.074
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20576
Xie Z, Meng J, Kong W, Wu Z, Lan F, Narengaowa, Hayashi Y, Yang Q, Bai Z, Nakanishi H, Qing H, Ni J.
Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease.
Aging Cell
2022
e13565
PubMed ID: 35181976
DOI: 10.1111/acel.13565
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20584
Akaishi T, Yamamoto S, Abe K.
3',4',7-Trihydroxyflavone Downregulates NO Production in LPS- or IFN-γ-Activated MG6 Microglial Cells by Attenuating the JNK-STAT1 Pathway.
Biol Pharm Bull
2022
45(3):301-308
PubMed ID: 35228396
DOI: 10.1248/bpb.b21-00841
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20685
Maejima Y, Horita S, Yokota S, Yamachi M, Shimizu M, Ono T, Yu Z, Tomita H, Shimomura K.
Surface translocation of Kir2.1 channel induces IL-1β secretion in microglia.
Mol Cell Neurosci
2022
120:103734
PubMed ID: 35508277
DOI: 10.1016/j.mcn.2022.103734
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20786
Kawamura N, Katsuura G, Yamada-Goto N, Nakama R, Kambe Y, Miyata A, Furuyashiki T, Narumiya S, Ogawa Y, Inui A.
Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice.
Sci Rep
2022
12(1):12604
PubMed ID: 35871167
DOI: 10.1038/s41598-022-16944-3
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20113
Ozawa S, Hori Y, Shimizu Y, Taniguchi A, Suzuki T, Wang W, Chiu YW, Koike R, Yokoshima S, Fukuyama T, Takatori S, Sohma Y, Kanai M, Tomita T.
Photo-oxygenation by a biocompatible catalyst reduces amyloid-β levels in Alzheimer's disease mice.
Brain
2021
PubMed ID: 33851209
DOI: 10.1093/brain/awab058
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20261
Ni J, Zhao J, Zhang X, Reinheckel T, Turk V, Nakanishi H.
Cathepsin H deficiency decreases hypoxia-ischemia-induced hippocampal atrophy in neonatal mice through attenuated TLR3/IFN-β signaling.
J Neuroinflammation
2021
18(1):176
PubMed ID: 34376208
DOI: 10.1186/s12974-021-02227-7
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20272
Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.
Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.
Sci Rep
2021
11(1):13471
PubMed ID: 34188113
DOI: 10.1038/s41598-021-92860-2
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16425
Novianti E, Katsuura G, Kawamura N, Asakawa A, Inui A.
Atractylenolide-III suppresses lipopolysaccharide-induced inflammation via downregulation of toll-like receptor 4 in mouse microglia
Heliyon
2021
7(10):e08269.
PubMed ID: 34765767
DOI: 10.1016/j.heliyon.2021.e08269
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16530
Saputra WD, Shono H, Ohsaki Y, Sultana H, Komai M, Shirakawa H.
Geranylgeraniol Inhibits Lipopolysaccharide-Induced Inflammation in Mouse-Derived MG6 Microglial Cells via NF-κB Signaling Modulation
Int J Mol Sci
2021
22(19):10543
PubMed ID: 34638882
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17029
Jiang M, Zhang X, Yan X, Mizutani S, Kashiwazaki H, Ni J, Wu Z.
GSK3β is involved in promoting Alzheimer's disease pathologies following chronic systemic exposure to Porphyromonas gingivalis lipopolysaccharide in amyloid precursor protein NL-F/NL-F knock-in mice
Brain Behav Immun
2021
98:1-12
PubMed ID: 34391814
DOI: 10.1016/j.bbi.2021.08.213
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11817
Suzuki T, Kohyama K, Moriyama K, Ozaki M, Hasegawa S, Ueno T, Saitoe M, Morio T, Hayashi M, Sakuma H.
Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor.
Eur. J. Immunol.
2020
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12025
Ogawa K, Yagi T, Guo T, Takeda K, Ohguchi H, Koyama H, Aotani D, Imaeda K, Kataoka H, Tanaka T.
Pemafibrate, a selective PPARα modulator, and fenofibrate suppress microglial activation through distinct PPARα and SIRT1-dependent pathways.
Biochem. Biophys. Res. Commun.
2020
PubMed ID: 32005522
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13230
Meng J, Liu Y, Xie Z, Qing H, Lei P, Ni J.
Nucleus distribution of cathepsin B in senescent microglia promotes brain aging through degradation of sirtuins.
Neurobiol Aging
2020
PubMed ID: 33049518
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13244
Shih JH, Tsai YF, Li IH, Chen MH, Huang YS.
Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-κB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.
Mar Drugs
2020
PubMed ID: 33003399
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13565
Gu Y, Wu Z, Zeng F, Jiang M, Teeling JL, Ni J, Takahashi I.
Systemic Exposure to Lipopolysaccharide from Porphyromonas gingivalis Induces Bone Loss-Correlated Alzheimer's Disease-Like Pathologies in Middle-Aged Mice
J Alzheimers Dis
2020
78(1):61-74
PubMed ID: 32925065
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13602
Tsutsui T, Kawahara H, Kimura R, Dong Y, Jiapaer S, Sabit H, Zhang J, Yoshida T, Nakada M, Hanayama R.
Glioma-derived extracellular vesicles promote tumor progression by conveying WT1
Carcinogenesis
2020
41(9):1238-1245
PubMed ID: 32463428
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11351
Ni J, Wu Z, Stoka V, Meng J, Hayashi Y, Peters C, Qing H, Turk V, Nakanishi H.
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice.
Aging Cell
2019
PubMed ID: 30575263
DOI: 10.1111/acel.12856
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5292
Huntula S, Saegusa H, Wang X, Zong S, Tanabe T.
Involvement of N-type Ca2+ channel in microglial activation and its implications to aging-induced exaggerated cytokine response.
Cell Calcium
2019
82:102059
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5306
Saputra WD, Aoyama N, Komai M, Shirakawa H4,.
Menaquinone-4 Suppresses Lipopolysaccharide-Induced Inflammation in MG6 Mouse Microglia-Derived Cells by Inhibiting the NF-κB Signaling Pathway.
Int J Mol Sci
2019
20(9). pii: E2317
PubMed ID: 31083359
DOI: 10.3390/ijms20092317
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5308
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh-Asahara N.
Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia.
Cells
2019
8(6):527
PubMed ID: 31159306
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Youssef M, Ibrahim A, Akashi K, Hossain MS.
PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells.
Neuroscience
2019
15;397:18-30
PubMed ID: 30496826
DOI: 10.1016/j.neuroscience.2018.11.030
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Fujikura M1, Iwahara N, Hisahara S, Kawamata J, Matsumura A, Yokokawa K, Saito T, Manabe T, Matsushita T, Suzuki S, Shimohama S.
CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway.
J Alzheimers Dis
2019
68(1):323-337
PubMed ID: 30775984
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Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y.
Regulatory Role of GRK2 in the TLR Signaling-Mediated iNOS Induction Pathway in Microglial Cells.
Front Pharmacol
2019
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Wang X, Saegusa H, Huntula S, Tanabe T.
Blockade of microglial Cav1.2 Ca2+ channel exacerbates the symptoms in a Parkinson's disease model.
Sci Rep
2019
PubMed ID: 31235768
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Ni J, Wu Z, Meng J, Saito T, Saido TC, Qing H, Nakanishi H.
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
J Neuroinflammation
2019
16(1):173
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Yasuhiro Nakagawa, Yuto Yano, Jeonggyu Lee, Yasutaka Anraku, Makoto Nakakido Makoto Nakakido, Kouhei Tsumoto, Horacio Cabral, and Mitsuhiro Ebara
Apoptotic Cell-Inspired Polymeric Particles for Controlling Microglial Inflammation toward Neurodegenerative Disease Treatment
ACS Biomater Sci Eng
2019
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Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
EMBO Mol Med
2018
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Kawakami M, Hattori M, Ohashi W, Fujimori T, Hattori K, Takebe M, Tomita K, Yokoo H, Matsuda N, Yamazaki M, Hattori Y.
Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy.
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Meng J, Ni J, Wu Z, Jiang M, Zhu A, Qing H, Nakanishi H.
The Critical Role of IL-10 in the Anti-neuroinflammatory and Anti-oxidative Effects of Rheum tanguticum on Activated Microglia
Oxid Med Cell Longev
2018
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Taiki Shima et al
Effects of antiepileptic drugs on microglial properties
Epilepsy & Seizure
2018
10, 22-32
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Serizawa K, Tomizawa-Shinohara H, Magi M, Yogo K, Matsumoto Y.
Anti-IL-6 receptor antibody improves pain symptoms in mice with experimental autoimmune encephalomyelitis.
J. Neuroimmunol.
2018
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Shimamura M, Nakagami H, Shimizu H, Mukai H, Watanabe R, Okuzono T, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Ju N, Mochizuki H, Morishita R.
Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.
Sci Rep
2018
PubMed ID: 30538259
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Shimamura M, Nakagami H, Shimizu H, Wakayama K, Kawano T, Ikeda Y, Hayashi H, Yoshida S, Mochizuki H, Morishita R.
Therapeutic Effects of Systemic Administration of the Novel RANKL-Modified Peptide, MHP1, for Ischemic Stroke in Mice.
Biomed Res Int
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Aiqin Zhu, Xin Zhong, Wei Nian, Shizheng Wu, Jie Meng, Junjun Ni, Yoshinori Hayashi, Zhou Wu, Hiroshi Nakanishi
Ratanasampil Suppresses the Hypoxia-Related Inflammatory Responses by Inhibiting Oxidative Stress and NF-kB Activation in Microglia
Journal of Alzheimer’s Disease & Parkinsonism
2018
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Wu Z, Ni J, Liu Y, Teeling JL, Takayama F, Collcutt A, Ibbett P, Nakanishi H.
Cathepsin B plays a critical role in inducing Alzheimer's disease-like phenotypes following chronic systemic exposure to lipopolysaccharide from Porphyromonas gingivalis in mice.
Brain Behav. Immun.
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Involvement of Host Defense Mechanisms against Toxoplasma gondii Infection in Anhedonic and Despair-Like Behaviors in Mice.
Infect. Immun.
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Omega-3 polyunsaturated fatty acids suppress the inflammatory responses of lipopolysaccharide-stimulated mouse microglia by activating SIRT1 pathways.
Biochim. Biophys. Acta
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Liu Y, Wu Z, Nakanishi Y, Ni J, Hayashi Y, Takayama F, Zhou Y, Kadawaki T, Nakanishi H.
Infection of microglia with Porphyromonas gingivalis promotes cell migration and an inflammatory response through the gingipain-mediated activation of protease-activated receptor-2 in mice.
Sci Rep
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Ferulic acid suppresses expression of tryptophan metabolic key enzyme indoleamine 2, 3-dioxygenase via NFκB and p38 MAPK in lipopolysaccharide-stimulated microglial cells.
Biosci Biotechnol Biochem
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Tanaka Y, Suzuki G, Matsuwaki T, Hosokawa M, Serrano G, Beach TG, Yamanouchi K, Hasegawa M, Nishihara M.
Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes
Hum Mol Genet
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Synergy between phenotypic modulation and ROS neutralization in reduction of inflammatory response of hypoxic microglia by using phosphatidylserine and antioxidant containing liposomes.
J Biomater Sci Polym Ed
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Neuronal Orphan G-Protein Coupled Receptor Proteins Mediate Plasmalogens-Induced Activation of ERK and Akt Signaling.
PLoS ONE
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Takayama F, Hayashi Y, Wu Z, Liu Y, Nakanishi H.
Diurnal dynamic behavior of microglia in response to infected bacteria through the UDP-P2Y6 receptor system.
Sci Rep
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Kurinami H, Shimamura M, Nakagami H, Shimizu H, Koriyama H, Kawano T, Wakayama K, Mochizuki H, Rakugi H, Morishita R.
A Novel Therapeutic Peptide as a Partial Agonist of RANKL in Ischemic Stroke.
Sci Rep
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The Critical Role of Proteolytic Relay through Cathepsins B and E in the Phenotypic Change of Microglia/Macrophage.
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Characterization of zinc uptake by mouse primary cultured astrocytes and microglia.
Metallomics
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Therapeutic concentration of lithium stimulates complement C3 production in dendritic cells and microglia via GSK-3 inhibition.
Glia
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Arch Biochem Biophys
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Leptomeningeal cells transduce peripheral macrophages inflammatory signal to microglia in reponse to Porphyromonas gingivalis LPS.
Mediators Inflamm
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Brazilian green propolis suppresses the hypoxia-induced neuroinflammatory responses by inhibiting NF-κB activation in microglia.
Oxid Med Cell Longev
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