Cell No. : Cell Name RCB2362 : HS-PSS  update : 2023/10/16
Comment			Human cell line derived from malignant peripheral nerve sheath tumor.
Comment from the depositor
Terms and conditions			There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form			Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)
			Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
	Basic information	Depositor	Sonobe, Hiroshi
		Originator	Sonobe, Hiroshi
		Year of deposit	2002
		Animal	_human < Mammals
		Genus	Homo
		Species	sapiens
		Gender	Male
		Tissue	prostate
		Disease name	malignant peripheral nerve sheath tumour (MPNST)
		Classification	cancer
		Lifespan	infinite
		Morphology	other
		Cellosaurus(Expasy)	CVCL_8717
			deposit info	lot info
		Medium	Medium List
		Culture type		Adherent cells
		Culture medium		DMEM (low glucose) + 10% FBS
		Antibiotics		Free
		Passage method		0.25% Trypsin
	Culture information	Passage ratio		1 : 8 split
		SC frequency		Subculture : once/week, Medium Renewal : 2 times/week
		Temperature		37 ℃
		CO2 concentration		5 %
		Freeze medium		Medium + 10% DMSO
		Freezing method		Slow freezing
		Mycoplasma		(-)
		Isozyme		LD, NP
		STR(human)		OK
Images			deposit info	lot info
Reference information		Reference	0
		User's Publication	6

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Reference

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User's Publication

17971  Magallón-Lorenz M, Terribas E, Ortega-Bertran S, Creus-Bachiller E, Fernández M, Requena G, Rosas I, Mazuelas H, Uriarte-Arrazola I, Negro A, Lausová T, Castellanos E, Blanco I, DeVries G, Kawashima H, Legius E, Brems H, Mautner V, Kluwe L, Ratner N, Wallace M, Fernández-Rodriguez J, Lázaro C, Fletcher JA, Reuss D, Carrió M, Gel B, Serra E.  Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis  iScience  2023  26(2):106096  PubMed ID: 36818284   DOI: 10.1016/j.isci.2023.106096

20115  Huang R, Fujimura A, Nakata E, Takihira S, Inoue H, Yoshikawa S, Hiyama T, Ozaki T, Kamiya A.  Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors.  Biochem Biophys Res Commun  2021  557:199-205  PubMed ID: 33872989   DOI: 10.1016/j.bbrc.2021.03.172

14763  Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA.  Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors  Mol Oncol  2017  11(9):1156-1171  PubMed ID: 28556483   DOI: 10.1002/1878-0261.12086

9577  Tanaka T, Kikuchi N, Goto K, Iino M.  Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.  Apoptosis  2016  21:594-608  PubMed ID: 26892009   DOI: 10.1007/s10495-016-1230-9

17970  Okano M, Sakata N, Ueda S, Takemura T.  Appropriate modulation of autophagy sensitizes malignant peripheral nerve sheath tumor cells to treatment with imatinib mesylate  J Pediatr Hematol Oncol  2014  36(3):200-11  PubMed ID: 24136016   DOI: 10.1097/MPH.0000000000000038

17972  Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, Iida K, Matsumoto Y, Hakozaki M, Aoki M, Iwasaki H, Dobashi Y, Nishiyama K, Iwamoto Y, Oda Y.  Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors  Clin Cancer Res  2013  19(2):450-61  PubMed ID: 23209032   DOI: 10.1158/1078-0432.CCR-12-1067