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Cell No. : Cell Name
RCB2362 : HS-PSS  update : 2023/10/16
CommentHuman cell line derived from malignant peripheral nerve sheath tumor.
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Sonobe, Hiroshi
Originator Sonobe, Hiroshi
Year of deposit 2002
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Male
Tissue prostate
Disease name malignant peripheral nerve sheath tumour (MPNST)
Classification cancer
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_8717
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
deposit info
lot info
Reference information Reference 0
User's Publication 8

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User's Publication
19741  Katayama H, Fujimura A, Huang R, Otani Y, Itano T, Fujiwara T, Kunisada T, Nakata E, Ozaki T.  Role of catecholamine synthases in the maintenance of cancer stem-like cells in malignant peripheral nerve sheath tumors  Cancer Sci  2024  115(3):871-882  PubMed ID: 38279513   DOI: 10.1111/cas.16077
21639  Takihira S, Yamada D, Osone T, Takao T, Sakaguchi M, Hakozaki M, Itano T, Nakata E, Fujiwara T, Kunisada T, Ozaki T, Takarada T.  PRRX1-TOP2A interaction is a malignancy-promoting factor in human malignant peripheral nerve sheath tumours.  Br J Cancer  2024    PubMed ID: 38448751   DOI: 10.1038/s41416-024-02632-8
17971  Magallón-Lorenz M, Terribas E, Ortega-Bertran S, Creus-Bachiller E, Fernández M, Requena G, Rosas I, Mazuelas H, Uriarte-Arrazola I, Negro A, Lausová T, Castellanos E, Blanco I, DeVries G, Kawashima H, Legius E, Brems H, Mautner V, Kluwe L, Ratner N, Wallace M, Fernández-Rodriguez J, Lázaro C, Fletcher JA, Reuss D, Carrió M, Gel B, Serra E.  Deep genomic analysis of malignant peripheral nerve sheath tumor cell lines challenges current malignant peripheral nerve sheath tumor diagnosis  iScience  2023  26(2):106096  PubMed ID: 36818284   DOI: 10.1016/j.isci.2023.106096
20115  Huang R, Fujimura A, Nakata E, Takihira S, Inoue H, Yoshikawa S, Hiyama T, Ozaki T, Kamiya A.  Adrenergic signaling promotes the expansion of cancer stem-like cells of malignant peripheral nerve sheath tumors.  Biochem Biophys Res Commun  2021  557:199-205  PubMed ID: 33872989   DOI: 10.1016/j.bbrc.2021.03.172
14763  Kolberg M, Bruun J, Murumägi A, Mpindi JP, Bergsland CH, Høland M, Eilertsen IA, Danielsen SA, Kallioniemi O, Lothe RA.  Drug sensitivity and resistance testing identifies PLK1 inhibitors and gemcitabine as potent drugs for malignant peripheral nerve sheath tumors  Mol Oncol  2017  11(9):1156-1171  PubMed ID: 28556483   DOI: 10.1002/1878-0261.12086
9577  Tanaka T, Kikuchi N, Goto K, Iino M.  Sec6/8 regulates Bcl-2 and Mcl-1, but not Bcl-xl, in malignant peripheral nerve sheath tumor cells.  Apoptosis  2016  21:594-608  PubMed ID: 26892009   DOI: 10.1007/s10495-016-1230-9
17970  Okano M, Sakata N, Ueda S, Takemura T.  Appropriate modulation of autophagy sensitizes malignant peripheral nerve sheath tumor cells to treatment with imatinib mesylate  J Pediatr Hematol Oncol  2014  36(3):200-11  PubMed ID: 24136016   DOI: 10.1097/MPH.0000000000000038
17972  Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, Iida K, Matsumoto Y, Hakozaki M, Aoki M, Iwasaki H, Dobashi Y, Nishiyama K, Iwamoto Y, Oda Y.  Prognostic significance of AKT/mTOR and MAPK pathways and antitumor effect of mTOR inhibitor in NF1-related and sporadic malignant peripheral nerve sheath tumors  Clin Cancer Res  2013  19(2):450-61  PubMed ID: 23209032   DOI: 10.1158/1078-0432.CCR-12-1067

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