| 利用者成果(英) |
|
19669
Parvin S, Aryal A, Yin S, Fell GG, Davids MS, Wu CJ, Letai A.
Targeting conditioned media dependencies and FLT-3 in chronic lymphocytic leukemia
Blood Adv
2023
7(19):5877-5889
PubMed ID: 37428863
DOI: 10.1182/bloodadvances.2022008207
|
|
17718
Muhowski EM, Ravikrishnan J, Gordon B, Yu L, Misra S, Walker B, Eathiraj S, Sampath D, Rogers KA, Byrd JC, Woyach JA.
Preclinical evaluation of combination nemtabrutinib and venetoclax in chronic lymphocytic leukemia
J Hematol Oncol
2022
15(1):166
PubMed ID: 36380319
DOI: 10.1186/s13045-022-01386-1
|
|
13511
Herbaux C, Kornauth C, Poulain S, Chong SJF, Collins MC, Valentin R, Hackett L, Tournilhac O, Lemonnier F, Dupuis J, Daniel A, Tomowiak C, Laribi K, Renaud L, Roos-Weil D, Rossi C, Van Den Neste EW, Leyronnas C, Merabet F, Malfuson JV, Tiab M, Ysebaert L, Ng SY, Morschhauser F, Staber PB, Davids MS.
BH3 profiling identifies ruxolitinib as a promising partner for venetoclax to treat T-cell prolymphocytic leukemia
Blood
2021
blood.2020007303
PubMed ID: 33598678
DOI: 10.1182/blood.2020007303
|
|
15651
Chen R, Tsai J, Thompson PA, Chen Y, Xiong P, Liu C, Burrows F, Sivina M, Burger JA, Keating MJ, Wierda WG, Plunkett W.
The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action
Blood Cancer J
2021
11(3):57
PubMed ID: 33714981
DOI: 10.1038/s41408-021-00436-0
|
|
15656
Herbst SA, Stolarczyk M, Becirovic T, Czernilofsky F, Liu Y, Kolb C, Knoll M, Herling M, Müller-Tidow C, Dietrich S.
Phagocytosis by stroma confounds coculture studies
iScience
2021
24(9):10306
PubMed ID: 34585113
DOI: 10.1016/j.isci.2021.103062
|
|
13375
Chong SJF, Iskandar K, Lai JXH, Qu J, Raman D, Valentin R, Herbaux C, Collins M, Low ICC, Loh T, Davids M, Pervaiz S.
Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism.
Nucleic Acids Res
2020
PubMed ID: 33245769
DOI: 10.1093/nar/gkaa1110
|
|
14794
Yi X, Sarkar A, Kismali G, Aslan B, Ayres M, Iles LR, Keating MJ, Wierda WG, Long JP, Bertilaccio MTS, Gandhi V.
AMG-176, an Mcl-1 Antagonist, Shows Preclinical Efficacy in Chronic Lymphocytic Leukemia
Clin Cancer Res
2020
26(14):3856-3867
PubMed ID: 31937611
DOI: 10.1158/1078-0432.CCR-19-1397
|
|
14299
Recasens-Zorzo C, Cardesa-Salzmann T, Petazzi P, Ros-Blanco L, Esteve-Arenys A, Clot G, Guerrero-Hernández M, Rodríguez V, Soldini D, Valera A, Moros A, Climent F, González-Barca E, Mercadal S, Arenillas L, Calvo X, Mate JL, Gutiérrez-García G, Casanova I, Mangues R, Sanjuan-Pla A, Bueno C, Menéndez P, Martínez A, Colomer D, Tejedor RE, Teixidó J, Campo E, López-Guillermo A, Borrell JI, Colomo L, Pérez-Galán P, Roué G.
Pharmacological modulation of CXCR4 cooperates with BET bromodomain inhibition in diffuse large B-cell lymphoma
Haematologica
2019
104(4):778-788
PubMed ID: 29954928
DOI: 10.3324/haematol.2017.180505
|
|
4352
Ding L, Zhang W, Yang L, Pelicano H, Zhou K, Yin R, Huang R, Zeng J.
Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia.
Onco Targets Ther
2018
11:5151-5170
PubMed ID: 30210236
DOI: 10.2147/OTT.S170392
|
|
14918
Esteve-Arenys A, Valero JG, Chamorro-Jorganes A, Gonzalez D, Rodriguez V, Dlouhy I, Salaverria I, Campo E, Colomer D, Martinez A, Rymkiewicz G, Pérez-Galán P, Lopez-Guillermo A, Roué G.
The BET bromodomain inhibitor CPI203 overcomes resistance to ABT-199 (venetoclax) by downregulation of BFL-1/A1 in in vitro and in vivo models of MYC+/BCL2+ double hit lymphoma
Oncogene
2018
37(14):1830-1844
PubMed ID: 29353886
DOI: 10.1038/s41388-017-0111-1
|
|
9948
Barile E, Marconi GD, De SK, Baggio C, Gambini L, Salem AF, Kashyap MK, Castro JE, Kipps TJ, Pellecchia M.
hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.
ACS Chem. Biol.
2017
12:444-455
PubMed ID: 28026162
DOI: 10.1021/acschembio.6b00962
|
|
4552
Deng J, Isik E, Fernandes SM, Brown JR, Letai A, Davids MS.
Bruton's tyrosine kinase inhibition increases BCL-2 dependence and enhances sensitivity to venetoclax in chronic lymphocytic leukemia.
Leukemia
2017
31(10):2075-2084
PubMed ID: 28111464
DOI: 10.1038/leu.2017.32
|
|
15654
Kashyap MK, Amaya-Chanaga CI, Kumar D, Simmons B, Huser N, Gu Y, Hallin M, Lindquist K, Yafawi R, Choi MY, Amine AA, Rassenti LZ, Zhang C, Liu SH, Smeal T, Fantin VR, Kipps TJ, Pernasetti F, Castro JE.
Targeting the CXCR4 pathway using a novel anti-CXCR4 IgG1 antibody (PF-06747143) in chronic lymphocytic leukemia
J Hematol Oncol
2017
10(1):112
PubMed ID: 28526063
DOI: 10.1186/s13045-017-0435-x
|
|
13477
Balakrishnan K, Fu M, Onida F, Wierda WG, Keating MJ, Gandhi V.
Reactivation of Smac-mediated apoptosis in chronic lymphocytic leukemia cells: mechanistic studies of Smac mimetic
Oncotarget
2016
7(26):39458-39472
PubMed ID: 27223062
DOI: 10.18632/oncotarget.8462
|
|
15659
Chen JY, Lai YS, Tsai HJ, Kuo CC, Yen BL, Yeh SP, Sun HS, Hung WC.
The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells
Sci Rep
2016
6:32428
PubMed ID: 27577048
DOI: 10.1038/srep32428
|
|
14285
Patel V, Balakrishnan K, Keating MJ, Wierda WG, Gandhi V.
Expression of executioner procaspases and their activation by a procaspase-activating compound in chronic lymphocytic leukemia cells
Blood
2015
125(7):1126-36
PubMed ID: 25538042
DOI: 10.1182/blood-2014-01-546796
|
|
14390
Zaman S, Shentu S, Yang J, He J, Orlowski RZ, Stellrecht CM, Gandhi V.
Targeting the pro-survival protein MET with tivantinib (ARQ 197) inhibits growth of multiple myeloma cells
Neoplasia
2015
17(3):289-300
PubMed ID: 25810013
DOI: 10.1016/j.neo.2015.01.006
|
|
15001
Balakrishnan K, Peluso M, Fu M, Rosin NY, Burger JA, Wierda WG, Keating MJ, Faia K, O'Brien S, Kutok JL, Gandhi V.
The phosphoinositide-3-kinase (PI3K)-delta and gamma inhibitor, IPI-145 (Duvelisib), overcomes signals from the PI3K/AKT/S6 pathway and promotes apoptosis in CLL
Leukemia
2015
29(9):1811-22
PubMed ID: 25917267
DOI: 10.1038/leu.2015.105
|
|
14394
Balakrishnan K, Burger JA, Fu M, Doifode T, Wierda WG, Gandhi V.
Regulation of Mcl-1 expression in context to bone marrow stromal microenvironment in chronic lymphocytic leukemia
Neoplasia
2014
16(12):1036-46
PubMed ID: 25499217
DOI: 10.1016/j.neo.2014.10.002
|
|
14395
El-Mabhouh AA, Ayres ML, Shpall EJ, Baladandayuthapani V, Keating MJ, Wierda WG, Gandhi V.
Evaluation of bendamustine in combination with fludarabine in primary chronic lymphocytic leukemia cells
Blood
2014
123(24):3780-9
PubMed ID: 24747434
DOI: 10.1182/blood-2013-12-541433
|
|
15655
Patel V, Chen LS, Wierda WG, Balakrishnan K, Gandhi V.
Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia
Leuk Lymphoma
2014
55(4):899-910
PubMed ID: 23837491
DOI: 10.3109/10428194.2013.819573
|
|
15661
Fiorcari S, Brown WS, McIntyre BW, Estrov Z, Maffei R, O'Brien S, Sivina M, Hoellenriegel J, Wierda WG, Keating MJ, Ding W, Kay NE, Lannutti BJ, Marasca R, Burger JA.
The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells
PLoS One
2013
8(12):e83830
PubMed ID: 24376763
DOI: 10.1371/journal.pone.0083830
|
|
15649
Sivina M, Hartmann E, Vasyutina E, Boucas JM, Breuer A, Keating MJ, Wierda WG, Rosenwald A, Herling M, Burger JA.
Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemia
Leukemia
2012
26(8):1812-20
PubMed ID: 22460735
DOI: 10.1038/leu.2012.63
|
|
15650
Davids MS, Deng J, Wiestner A, Lannutti BJ, Wang L, Wu CJ, Wilson WH, Brown JR, Letai A.
Decreased mitochondrial apoptotic priming underlies stroma-mediated treatment resistance in chronic lymphocytic leukemia
Blood
2012
120(17):3501-9
PubMed ID: 22955911
DOI: 10.1182/blood-2012-02-414060
|
|
17207
Nakamori Y, Liu B, Ohishi K, Suzuki K, Ino K, Matsumoto T, Masuya M, Nishikawa H, Shiku H, Hamada H, Katayama N.
Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis
Br J Haematol
2012
157(6):674-86
PubMed ID: 22463758
DOI: 10.1111/j.1365-2141.2012.09109.x
|
|
15652
Chen R, Guo L, Chen Y, Jiang Y, Wierda WG, Plunkett W.
Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia
Blood
2011
117(1):156-64
PubMed ID: 20971952
DOI: 10.1182/blood-2010-01-262808
|
|
15653
Manshouri T, Estrov Z, Quintás-Cardama A, Burger J, Zhang Y, Livun A, Knez L, Harris D, Creighton CJ, Kantarjian HM, Verstovsek S.
Bone marrow stroma-secreted cytokines protect JAK2(V617F)-mutated cells from the effects of a JAK2 inhibitor
Cancer Res
2011
71(11):3831-40
PubMed ID: 21512135
DOI: 10.1158/0008-5472.CAN-10-4002
|
戻る
細胞材料の再培養方法 (
HPS以外・
HPS )
ページトップへ
細胞材料開発室サイト
