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細胞番号 : 細胞名
RCB2293 : ACC-MESO-4  update : 2021/02/26
細胞特性(Comment:英)Human malignant pleural mesothelioma cell line.
細胞特性(日)ヒト悪性胸膜中皮腫由来細胞株(アスベスト暴露歴の疑いあり)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)In publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Cancer Sci 2006;97:387-394) designated by the DEPOSITOR is required.
使用条件(日)利用者は、研究成果の公表にあたって寄託者の指定する文献 (Cancer Sci 2006;97:387-394) を引用すること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Sekido, Yoshitaka
樹立者 Hida, Toyoaki
寄託日 2006
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Japanese
性別 Male
59 years
採取組織 malignant pleural mesothelioma, pleural fluid
病名 malignant pleural mesothelioma
細胞分類 cancer
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin or (0.05% trypsin + 0.53mM EDTA) or (0.25% trypsin + 0.53mM EDTA)
継代密度 1 : 6 split
継代・培地交換頻度 Subculture : once/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 1件
Reference(日) 0件
利用者成果(英) 32件
利用者成果(日) 0件

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Reference(英)
3337  Usami, Noriyasu, Fukui, Takayuki, Kondo, Masashi, Taniguchi, Tetsuo, Yokoyama, Toshihiko, Mori, Shoichi, Yokoi, Kohei, Horio, Yoshitsugu, Shimokata, Kaoru, Sekido, Yoshitaka, Hida, Toyoaki  Establishment and characterization of four malignant pleural mesothelioma cell lines from Japanese patients.  Cancer Sci  2006  97:387-94  PubMed ID: 16630136

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Reference(日)

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利用者成果(英)
20093  Yang H, Hall SRR, Sun B, Zhao L, Gao Y, Schmid RA, Tan ST, Peng RW, Yao F.  NF2 and Canonical Hippo-YAP Pathway Define Distinct Tumor Subsets Characterized by Different Immune Deficiency and Treatment Implications in Human Pleural Mesothelioma.  Cancers (Basel)  2021  13(7)  PubMed ID: 33805359
6938  Okonska A, Bühler S, Rao V, Ronner M, Blijlevens M, van der Meulen-Muileman IH, de Menezes RX, Wipplinger M, Oehl K, Smit EF, Weder W, Stahel RA, Penengo L, van Beusechem VW, Felley-Bosco E.  Functional genomic screen in mesothelioma reveals that loss of function of BRCA1-associated-protein-1 induces chemoresistance to ribonucleotide reductase inhibition.  Mol Cancer Ther  2020  19(2):552-563  PubMed ID: 31619462
12125  Fujii T, Itami H, Uchiyama T, Morita K, Nakai T, Hatakeyama K, Sugimoto A, Shimada K, Tsuji S, Ohbayashi C.  HEG1-responsive microRNA-23b regulates cell proliferation in malignant mesothelioma cells.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 32284171
13129  Kojima M, Kajino K, Momose S, Wali N, Hlaing MT, Han B, Yue L, Abe M, Fujii T, Ikeda K, Hino O.  Possible reversibility between epithelioid and sarcomatoid types of mesothelioma is independent of ERC/mesothelin expression.  Respir Res  2020    PubMed ID: 32677949
13171  Yang H, Xu D, Yang Z, Yao F, Zhao H, Schmid RA, Peng RW.  Systematic Analysis of Aberrant Biochemical Networks and Potential Drug Vulnerabilities Induced by Tumor Suppressor Loss in Malignant Pleural Mesothelioma.  Cancers (Basel)  2020    PubMed ID: 32824422
13236  Jotatsu T, Izumi H, Morimoto Y, Yatera K.  Selection of microRNAs in extracellular vesicles for diagnosis of malignant pleural mesothelioma by in vitro analysis.  Oncol Rep  2020    PubMed ID: 33000251
13275  Sakai K, Nishiuchi T, Tange S, Suzuki Y, Yano S, Terashima M, Suzuki T, Matsumoto K.  Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion.  Sci Rep  2020    PubMed ID: 33028834
13551  Han B, Lee-Okada HC, Ishimine M, Orita H, Nishikawa K, Takagaki T, Kajino K, Yokomizo T, Hino O, Kobayashi T.  Combined use of irinotecan and p53 activator enhances growth inhibition of mesothelioma cells  FEBS Open Bio  2020  10(11):2375-2387  PubMed ID: 32961616
13608  Kuwata T, Yoneda K, Mori M, Kanayama M, Kuroda K, Kaneko MK, Kato Y, Tanaka F.  Detection of Circulating Tumor Cells (CTCs) in Malignant Pleural Mesothelioma (MPM) with the "Universal" CTC-Chip and An Anti-Podoplanin Antibody NZ-1.2  Cells  2020  9(4):888  PubMed ID: 32260559
11413  Nakayama K, Seike M, Noro R, Takeuchi S, Matsuda K, Kunugi S, Kubota K, Gemma A.  Tenascin XB Is a Novel Diagnostic Marker for Malignant Mesothelioma.  Anticancer Res.  2019    PubMed ID: 30711938
11837  Xu D, Yang H, Yang Z, Berezowska S, Gao Y, Liang SQ, Marti TM, Hall SRR, Dorn P, Kocher GJ, Schmid RA, Peng RW.  Endoplasmic Reticulum Stress Signaling as a Therapeutic Target in Malignant Pleural Mesothelioma.  Cancers (Basel)  2019    PubMed ID: 31597321
12382  Yoneda K, Kuwata T, Chikaishi Y, Mori M, Kanayama M, Takenaka M, Oka S, Hirai A, Imanishi N, Kuroda K, Ichiki Y, Ohnaga T, Tanaka F.  Detection of circulating tumor cells with a novel microfluidic system in malignant pleural mesothelioma  Cancer Sci  2019  110(2):726-733  PubMed ID: 30499156
12383  Hino O, Abe M, Han B, Yan Y.  In commemoration of the 2018 Mataro Nagayo Prize: A road to early diagnosis and monitoring of asbestos-related mesothelioma  Cancer Sci  2019  110(5):1518-1524  PubMed ID: 30888083
10679  Yoneda K, Chikaishi Y, Kuwata T, Ohnaga T, Tanaka F.  Capture of mesothelioma cells with 'universal' CTC-chip.  Oncol Lett  2018  15:2635-2640  PubMed ID: 29434985
11150  Ohno Y, Shingyoku S, Miyake S, Tanaka A, Fudesaka S, Shimizu Y, Yoshifuji A, Yamawaki Y, Yoshida S, Tanaka S, Sakura K, Tanaka T.  Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways.  Oncogene  2018  37(49):6357-6367  PubMed ID: 30061637
11107  Xu D, Liang SQ, Yang H, Luthi U, Riether C, Berezowska S, Marti TM, Hall SRR, Bruggmann R, Kocher GJ, Schmid RA, Peng RW.  Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma.  Br. J. Cancer  2018  119(1):65-75  PubMed ID: 29921948
11217  Matsuura R, Kaji H, Tomioka A, Sato T, Narimatsu H, Moriwaki Y, Misawa H, Imai K, Tsuji S.  Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1.  Sci Rep  2018    PubMed ID: 30250045
7034  Tsuji S, Washimi K, Kageyama T, Yamashita M, Yoshihara M, Matsuura R, Yokose T, Kameda Y, Hayashi H, Morohoshi T, Tsuura Y, Yusa T, Sato T, Togayachi A, Narimatsu H, Nagasaki T, Nakamoto K, Moriwaki Y, Misawa H, Hiroshima K, Miyagi Y, Imai K.  HEG1 is a novel mucin-like membrane protein that serves as a diagnostic and therapeutic target for malignant mesothelioma.  Sci Rep  2017  7:45768  PubMed ID: 28361969
10043  Hida T, Hamasaki M, Matsumoto S, Sato A, Tsujimura T, Kawahara K, Iwasaki A, Okamoto T, Oda Y, Honda H, Nabeshima K.  Immunohistochemical detection of MTAP and BAP1 protein loss for mesothelioma diagnosis: Comparison with 9p21 FISH and BAP1 immunohistochemistry.  Lung Cancer  2017  104:98-105  PubMed ID: 28213009
10329  Kresoja-Rakic J, Sulemani M, Kirschner MB, Ronner M, Reid G, Kao S, Schwaller B, Weder W, Stahel RA, Felley-Bosco E.  Posttranscriptional Regulation Controls Calretinin Expression in Malignant Pleural Mesothelioma.  Front Genet  2017  8:70  PubMed ID: 28611824
10639  Shigeeda W, Shibazaki M, Yasuhira S, Masuda T, Tanita T, Kaneko Y, Sato T, Sekido Y, Maesawa C.  Hyaluronic acid enhances cell migration and invasion via the YAP1/TAZ-RHAMM axis in malignant pleural mesothelioma.  Oncotarget  2017  8:93729-93740  PubMed ID: 29212185
9731  Mizutani N, Abe M, Matsuoka S, Kajino K, Wakiya M, Ohtsuji N, Hatano R, Morimoto C, Hino O.  Establishment of anti-mesothelioma monoclonal antibodies.  BMC Res Notes  2016  9:324  PubMed ID: 27342200
5814  Lourdes Cortes-Dericks, Laurene Froment, Gregor Kocher, Author information Article notes Copyright and License infor  Human lung-derived mesenchymal stem cell-conditioned medium exerts in vitro antitumor effects in malignant pleural mesothelioma cell lines  Stem Cell Res Ther  2016  7:25  PubMed ID: 26861734
10036  Jelena Kresoja-Rakic, Esra Kapaklikaya, Gabriela Ziltener, Damian Dalcher, Raffaella Santoro, Brock C Christensen, Kevin C Johnson, Beat Schwaller, Walter Weder, Rolf A Stahel, Emanuela Felley-Bosco  Identification of Cis- And Trans-Acting Elements Regulating Calretinin Expression in Mesothelioma Cells  Oncotarget  2016  7(16):21272-86  PubMed ID: 26848772
12632  Amatya VJ, Mawas AS, Kushitani K, Mohi El-Din MM, Takeshima Y.  Differential microRNA expression profiling of mesothelioma and expression analysis of miR-1 and miR-214 in mesothelioma  Int J Oncol  2016  48(4):1599-607  PubMed ID: 26820394
12680  Kushitani K, Amatya VJ, Mawas AS, Miyata Y, Okada M, Takeshima Y.  Use of Anti-Noxa Antibody for Differential Diagnosis between Epithelioid Mesothelioma and Reactive Mesothelial Hyperplasia  Pathobiology  2016  83(1):33-40  PubMed ID: 26735863
13697  Cortes-Dericks L, Froment L, Boesch R, Schmid RA, Karoubi G.  Cisplatin-resistant cells in malignant pleural mesothelioma cell lines show ALDH(high)CD44(+) phenotype and sphere-forming capacity  BMC Cancer  2014  14:304  PubMed ID: 24884875
8088  Iwahori K, Serada S, Fujimoto M, Nomura S, Osaki T, Lee CM, Mizuguchi H, Takahashi T, Ripley B, Okumura M, Kawase I, Kishimoto T, Naka T.  Overexpression of SOCS3 exhibits preclinical antitumor activity against malignant pleural mesothelioma.  Int. J. Cancer  2011  129:1005-17  PubMed ID: 20949562
8199  Hasegawa S, Koshikawa-Yano M, Saito S, Morokoshi Y, Furukawa T, Aoki I, Saga T.  Molecular imaging of mesothelioma by detection of manganese-superoxide dismutase activity using manganese-enhanced magnetic resonance imaging.  Int. J. Cancer  2011  128:2138-46  PubMed ID: 20617513
8186  Tsuji S, Tsuura Y, Morohoshi T, Shinohara T, Oshita F, Yamada K, Kameda Y, Ohtsu T, Nakamura Y, Miyagi Y.  Secretion of intelectin-1 from malignant pleural mesothelioma into pleural effusion.  Br. J. Cancer  2010  103:517-23  PubMed ID: 20628387
8379  Suzuki Y, Sakai K, Ueki J, Xu Q, Nakamura T, Shimada H, Nakamura T, Matsumoto K.  Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma.  Int. J. Cancer  2010  127:1948-57  PubMed ID: 20104519
13735  Ito A, Hagiyama M, Mimura T, Matsumoto M, Wakayama T, Iseki S, Yokozaki H, Okada M.  Expression of cell adhesion molecule 1 in malignant pleural mesothelioma as a cause of efficient adhesion and growth on mesothelium  Lab Invest  2008  88(5):504-14  PubMed ID: 18332875

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