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Cell No. : Cell Name
RCB2280 : HCE-T  update : 2024/06/12
CommentSV40-Adeno vector transformed cornea cells. 64kD keratin producing. Choleratoxin-free medium. To the users who purchased this cell line for OECD Test Guideline No. 494 (PDF 91KB)
Comment from the depositor
Terms and conditions1) In publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Invest Ophthalmol Vis Sci. 1995;36:614-621)
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Araki-Sasaki Kaoru
Originator Araki-Sasaki Kaoru
Year of deposit 2005
Original cell RCB1384
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 49 years
Tissue cornea
Disease name maxillary sinus carcinoma
Classification transformed
Recombinant recombinant
Exogene SV40-large T
Memo_1 Mycoplasma was eliminated with MC-210 by the depositor.
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1272
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM/HamF12 + 5% FBS + 5μg/ml Insulin + 10ng/ml human EGF + 0.5% DMSO
Antibiotics Free
Passage method 0.25% Trypsin or (0.25% Trypsin + 0.02% EDTA) or (0.25% Trypsin + 0.04% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
deposit info
lot info
Reference information Reference 5
User's Publication 242

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9981  Araki-Sasaki K, Aizawa S, Hiramoto M, Nakamura M, Iwase O, Nakata K, Sasaki Y, Mano T, Handa H, Tano Y.  Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line.  J Cell Physiol  2000  182(2):189-95  PubMed ID: 10623882   DOI: 10.1002/(SICI)1097-4652(200002)182:2<189::AID-JCP7>3.0.CO;2-9
9980  Saarinen-Savolainen P, Järvinen T, Araki-Sasaki K, Watanabe H, Urtti A. Author information  Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and cyclodextrins in an immortalized human corneal epithelial cell line.  Pharm Res  1998  15(8):1275-80  PubMed ID: 9706061   DOI: 10.1023/a:1011956327987
2263  Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H  An SV40-immortalized human corneal epithelial cell line and its characterization.  Invest Ophthalmol Vis Sci  1995  36:614-21  PubMed ID: 7534282  
2262  Zhang Y, Araki-Sasaki K, Handa H, Akhtar, R A  Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells.  Curr Eye Res  1995  14:563-71  PubMed ID: 7587302   DOI: 10.3109/02713689508998403
2261  Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang, X Z, Hosaka Y, Aizawa S, Handa H  Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector.  Invest Ophthalmol Vis Sci  1993  34:2665-71  PubMed ID: 7688358  

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User's Publication
21704  Zeng Z, Yoshida Y, Wang D, Fujii Y, Shen M, Mimura T, Tanaka Y.  Inflammatory Cytokines and Chemokines Are Synergistically Induced in a ROS-Dependent Manner by a Co-Culture of Corneal Epithelial Cells and Neutrophil-like Cells in the Presence of Particulate Matter.  Antioxidants (Basel)  2024  13(4)  PubMed ID: 38671915   DOI: 10.3390/antiox13040467
21742  Lochenie C, Duncan S, Zhou Y, Fingerhut L, Kiang A, Benson S, Jiang G, Liu X, Mills B, Vendrell M.  Photosensitizer-Amplified Antimicrobial Materials for Broad-spectrum Ablation of Resistant Pathogens in Ocular Infections.  Adv Mater  2024  e2404107  PubMed ID: 38762778   DOI: 10.1002/adma.202404107
17736  Ong HS, Riau AK, Yam GH, Yusoff NZBM, Han EJY, Goh TW, Lai RC, Lim SK, Mehta JS.  Mesenchymal Stem Cell Exosomes as Immunomodulatory Therapy for Corneal Scarring  Int J Mol Sci  2023  24(8):7456  PubMed ID: 37108619   DOI: 10.3390/ijms24087456
17782  Ban Y, Yoshida Y, Aziza Y, Kinoshita S, Sotozono C.  Strengthening of the barrier function in human telomerase reverse transcription (hTERT) immortalized corneal and conjunctival epithelium by double-stranded RNA  Exp Eye Res  2023  227:109357  PubMed ID: 36572167   DOI: 10.1016/j.exer.2022.109357
19536  Wang J, Shang KT, Ma QH, Dong ZY, Chen YH, Yao YF.  Herpes Simplex Virus Type 1 Infection Induces the Formation of Tunneling Nanotubes  Microorganisms  2023  11(8):1916  PubMed ID: 37630476   DOI: 10.3390/microorganisms11081916
19579  Hao R, Hu S, Zhang H, Chen X, Yu Z, Ren J, Guo H, Yang H.  Mechanical stimulation on a microfluidic device to highly enhance small extracellular vesicle secretion of mesenchymal stem cells  Mater Today Bio  2023  18:100527  PubMed ID: 36619203   DOI: 10.1016/j.mtbio.2022.100527
19618  Anitua E, de la Fuente M, Sánchez-Ávila RM, de la Sen-Corcuera B, Merayo-Lloves J, Muruzábal F.  Beneficial Effects of Plasma Rich in Growth Factors (PRGF) Versus Autologous Serum and Topical Insulin in Ocular Surface Cells  Curr Eye Res  2023  48(5):456-464  PubMed ID: 36695530   DOI: 10.1080/02713683.2023.2173237
19623  Chen K, Jin L, Wen Y, Yang Q, Li X, Zhang L, Wang L, Xia Y, Chen Z, Xie C, Tong J, Shen Y.  Blue light impairs cornea and corneal wound healing by downregulating VCAM1 partly  iScience  2023  26(12):108448  PubMed ID: 38034364   DOI: 10.1016/j.isci.2023.108448
19660  Ryosuke Fukuda, Nargis Mahmuda, Sawangrat Kasirawat, Ryo Kawakami, Rumina Shima, Yu Mizukami, Shiori Shibukawa, Yuki Tada, Fumitake Kawanishi, Masatsune Ogura, Kota Matsuki, Yoshinori Nagai, Eri Nakano, Kenji Suda, Akitaka Tsujikawa, Tatsuya Murakami  High‐Density Lipoprotein Engineering for Eye‐Drop Treatment of Age‐Related Macular Degeneration  Advanced Therapeutics  2023  6    DOI: 10.1002/adtp.202300186
19726  Chai N, Stachon T, Nastaranpour M, Li Z, Seitz B, Ulrich M, Langenbucher A, Szentmáry N.  Assessment of Rose Bengal Photodynamic Therapy on Viability and Proliferation of Human Keratolimbal Epithelial and Stromal Cells In Vitro  Klin Monbl Augenheilkd  2023  Jun 19  PubMed ID: 36808578   DOI: 10.1055/a-2038-8899
21275  Kang WS, Kim E, Choi H, Lee KH, Kim KJ, Lim D, Choi SY, Kim Y, Son SA, Kim JS, Kim S.  Therapeutic Potential of Peucedanum japonicum Thunb. and Its Active Components in a Delayed Corneal Wound Healing Model Following Blue Light Irradiation-Induced Oxidative Stress.  Antioxidants (Basel)  2023  12(6)  PubMed ID: 37371901   DOI: 10.3390/antiox12061171
21302  Iwasaki T, Uchiyama R, Nosaka K.  New Candidate Preservative in Ophthalmic Solution Instead of Benzalkonium Chloride: 1,3-Didecyl-2-methyl Imidazolium Chloride.  Chem Pharm Bull (Tokyo)  2023  71(7):552-557  PubMed ID: 37394604   DOI: 10.1248/cpb.c23-00115
21417  Ghosh S, Humera Khathun AH, Athulya GS, Vignesh P, Mathan L, Mudaraddi N, Narendran S, Lalitha P, Venkatesh Prajna N.  Host cell-type and pathogen-specific immunomodulatory functions of macrophage migration inhibitory factor (MIF) in infectious keratitis.  Exp Eye Res  2023  109669  PubMed ID: 37774962   DOI: 10.1016/j.exer.2023.109669
21457  Abdalkader RK, Fujita T.  Corneal epithelium models for safety assessment in drug development: Present and future directions.  Exp Eye Res  2023  237:109697  PubMed ID: 37890755   DOI: 10.1016/j.exer.2023.109697
21463  Areesanan A, Nicolay S, Keller M, Zimmermann-Klemd AM, Potterat O, Gründemann C.  Potential benefits of Malva sylvestris in dry-eye disease pathology in vitro based on antioxidant, wound-healing and anti-inflammatory properties.  Biomed Pharmacother  2023  168:115782  PubMed ID: 37924786   DOI: 10.1016/j.biopha.2023.115782
21535  Chai N, Stachon T, Berger T, Li Z, Seitz B, Langenbucher A, Szentmáry N.  Human corneal epithelial cell and fibroblast migration and growth factor secretion after rose bengal photodynamic therapy (RB-PDT) and the effect of conditioned medium.  PLoS One  2023  18(12):e0296022  PubMed ID: 38150488   DOI: 10.1371/journal.pone.0296022
21557  Malakouti-Nejad M, Monti D, Burgalassi S, Bardania H, Elahi E, Morshedi D.  A comparison between the effects of two liposome-encapsulated bevacizumab formulations on ocular neovascularization inhibition.  Colloids Surf B Biointerfaces  2023  234:113708  PubMed ID: 38141384   DOI: 10.1016/j.colsurfb.2023.113708
17539  Otsu W, Yako T, Sugisawa E, Nakamura S, Tsusaki H, Umigai N, Shimazawa M, Hara H.  Crocetin protects against mitochondrial damage induced by UV-A irradiation in corneal epithelial cell line HCE-T cells  J Pharmacol Sci  2022  150(4):279-288  PubMed ID: 36344051   DOI: 10.1016/j.jphs.2022.10.005
17614  Abbate I, Zappulla C, Santonocito M, Viola S, La Rosa LR, De Pasquale G, Caviola E, Meloni M, Curatolo MC, Mazzone MG.  Preclinical study of a new matrix to help the ocular surface in dry eye disease  Exp Eye Res  2022  222:109168  PubMed ID: 35777472   DOI: 10.1016/j.exer.2022.109168
17632  Yihui Song, Sheng Hua, Sepidar Sayyar, Zhi Chen, Johnson Chung, Xiao Liu, Zhilian Yue, Cameron Angus, Benjamin Filippi, Stephen Beirne, Gordon Wallace, Gerard Sutton, Jingjing You  Corneal bioprinting using a high concentration pure collagen I transparent bioink  Corneal bioprinting using a high concentration pure collagen I transparent bioink  2022  28:e00235    DOI: 10.1016/j.bprint.2022.e00235
18228  Jactty Chew, Tommy Tong, Mun Lok Chua, Mohammad Ridwane Mungroo, Yi Xing Yap, Misni Misran, Lai Ti Gew  The Antibacterial Activity of Zinc Oxide Nanoparticle-Loaded Soft Contact Lens  Current Chemical Biology  2022  16:138-144    DOI: 10.2174/2212796816666220419121948
15508  Yu Z, Hao R, Du J, Wu X, Chen X, Zhang Y, Li W, Gu Z, Yang H.  A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles  iScience  2022  25(5):104200  PubMed ID: 35479406   DOI: 10.1016/j.isci.2022.104200
20515  Arunachalam D, Ramanathan SM, Menon A, Madhav L, Ramaswamy G, Namperumalsamy VP, Prajna L, Kuppamuthu D.  Expression of immune response genes in human corneal epithelial cells interacting with Aspergillus flavus conidia.  BMC Genomics  2022  23(1):5  PubMed ID: 34983375   DOI: 10.1186/s12864-021-08218-5
20586  Schwab R, Reichl S.  Dexamethasone-loaded keratin films for ocular surface reconstruction.  J Mater Sci Mater Med  2022  33(3):29  PubMed ID: 35244790   DOI: 10.1007/s10856-021-06638-z
16666  Abdalkader R, Kamei KI.  An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells  Hum Cell  2022  35(4):1016-1029  PubMed ID: 35553384   DOI: 10.1007/s13577-022-00713-5
16695  Kanae Moriya, Hisanori Shimizu, Daisuke Kamei, Satoko Handa, Tadanori Sasaki, Yasuhisa Kato  Evaluation of corneal damage caused by the anticancer drug S-1 in human corneal epithelial cells  The Showa University Journal of Medical Sciences  2022  34:27-32    DOI: 10.15369/sujms.34.27
20797  Cai J, Jacob S, Kurupi R, Dalton KM, Coon C, Greninger P, Egan RK, Stein GT, Murchie E, McClanaghan J, Adachi Y, Hirade K, Dozmorov M, Glod J, Boikos SA, Ebi H, Hao H, Caponigro G, Benes CH, Faber AC.  High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition.  Cell Rep  2022  40(4):111095  PubMed ID: 35905710   DOI: 10.1016/j.celrep.2022.111095
20929  Anitua E, Fuente M, Merayo-Lloves J, Muruzabal F.  Optimization of a Plasma Rich in Growth Factors Membrane for the Treatment of Inflammatory Ocular Diseases.  Bioengineering (Basel)  2022  9(10)  PubMed ID: 36290475   DOI: 10.3390/bioengineering9100508
13379  Wu C, Or PW, Chong JIT, Pathirage Don IKK, Lee CHC, Wu K, Yu M, Lam DCC, Yang Y.  Extended Delivery of Pirfenidone with Novel, Soft Contact Lenses In Vitro and In Vivo.  J Ocul Pharmacol Ther  2021  37(2):75-83.  PubMed ID: 33297836   DOI: 10.1089/jop.2020.0058
13392  Lai YH, Lee PY, Lu CY, Liu YR, Wang SC, Liu CC, Chang YC, Chen YH, Su CC, Li CY, Liu PL.  Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.  FASEB J  2021    PubMed ID: 33341997   DOI: 10.1096/fj.202001106RRR
20039  Kaluzhny Y, Klausner M.  In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development.    2021    PubMed ID: 33544359   DOI: 10.1007/s11626-020-00533-7
20091  Xu M, Sivak JG, McCanna DJ.  Neutralization of the eye and skin irritant benzalkonium chloride using UVC radiation.  Cutan Ocul Toxicol  2021  1-7  PubMed ID: 33771058   DOI: 10.1080/15569527.2021.1902339
20140  Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T.  The transcriptome of wild-type and immortalized corneal epithelial cells.  Sci Data  2021  8(1):126  PubMed ID: 33963195   DOI: 10.1038/s41597-021-00908-9
14367  Dalton KM, Krytska K, Lochmann TL, Sano R, Casey C, D'Aulerio A, Khan QA, Stein Crowther G, Coon C, Cai J, Jacob S, Kurupi R, Hu B, Dozmorov M, Greninger P, Souers AJ, Benes CH, Mossé YP, Faber AC.  Venetoclax-based rational combinations are effective in models of MYCN-amplified neuroblastoma  Mol Cancer Ther  2021    PubMed ID: 34088831   DOI: 10.1158/1535-7163.MCT-20-0710
14518  Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z.  New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations  Drug Des Devel Ther  2021  15:351-360  PubMed ID: 33568896   DOI: 10.2147/DDDT.S264745
14702  Račić A, Čalija B, Milić J, Dukovski BJ, Lovrić J, Dobričić V, Micov A, Vuković M, Stepanović-Petrović R, Krajišnik D.  Formulation of olopatadine hydrochloride viscous eye drops - physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches  Eur J Pharm Sci  2021  105906  PubMed ID: 34118409   DOI: 10.1016/j.ejps.2021.105906
15098  Agnė Žiniauskaitė, Vytautas Cėpla, Tadas Jelinskas, Romuald Eimont, Artūras Ulčinas, Rūta Aldonytė, Ramūnas Valiokas, Giedrius Kalesnykas, Jenni J. Hakkarainen  Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability  Sci  2021  3:30    DOI: 10.3390/sci3030030
20266  Abdalkader R, Chaleckis R, Wheelock CE, Kamei KI.  Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip.  Exp Eye Res  2021  209:108646  PubMed ID: 34102209   DOI: 10.1016/j.exer.2021.108646
20368  Lin TL, Cheng C, Zeng WT, Duan F, Pei YH, Liu XP, Shang F, Wu KL.  Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study.  Int J Ophthalmol  2021  14(10):1463-1472  PubMed ID: 34667721   DOI: 10.18240/ijo.2021.10.01
15676  Ghosh AK, Thapa R, Hariani HN, Volyanyuk M, Ogle SD, Orloff KA, Ankireddy S, Lai K, Žiniauskaitė A, Stubbs EB Jr, Kalesnykas G, Hakkarainen JJ, Langert KA, Kaja S.  Poly(lactic-co-glycolic acid) Nanoparticles Encapsulating the Prenylated Flavonoid, Xanthohumol, Protect Corneal Epithelial Cells from Dry Eye Disease-Associated Oxidative Stress  Pharmaceutics  2021  13(9):1362  PubMed ID: 34575438   DOI: 10.3390/pharmaceutics13091362
15678  Magny R, Regazzetti A, Kessal K, Baudouin C, Mélik-Parsadaniantz S, Laprévote O, Brignole-Baudouin F, Auzeil N, Roulland E.  Deepening of lipidome annotation by associating cross-metathesis reaction with mass spectrometry: application to an in vitro model of corneal toxicity  Anal Bioanal Chem  2021  413(19):4825-4836  PubMed ID: 34125263   DOI: 10.1007/s00216-021-03438-w
20447  Otsu W, Ishida K, Chinen N, Nakamura S, Shimazawa M, Tsusaki H, Hara H.  Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells.  Sci Rep  2021  11(1):18555  PubMed ID: 34535730   DOI: 10.1038/s41598-021-97956-3
20505  Goto R, Yamada S, Otake H, Nakazawa Y, Oka M, Yamamoto N, Sasaki H, Nagai N.  Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats.  Pharmaceutics  2021  13(12)  PubMed ID: 34959281   DOI: 10.3390/pharmaceutics13121999
14734  Arunachalam D, Namperumalsamy VP, Prajna L, Kuppamuthu D.  Human Corneal Epithelial Cells Internalize Aspergillus flavus Spores by Actin-Mediated Endocytosis  Infect Immun  2021  89(6):e00794-20  PubMed ID: 33753415   DOI: 10.1128/IAI.00794-20
11687  Mungroo MR, Tong T, Khan NA, Anuar TS, Maciver SK, Siddiqui R.  Development of anti-acanthamoebic approaches  Int Microbiol  2021  24(3):363-371  PubMed ID: 33754231   DOI: 10.1007/s10123-021-00171-3
16667  Wu C, Or PW, Chong JIT, K Pathirage Don IK, Lee CHC, Wu K, Yu M, Lam DCC, Yang Y.  Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo  Drug Deliv  2021  28(1):634-641  PubMed ID: 33779455   DOI: 10.1080/10717544.2021.1895911
16669  Banshoya K, Fujita C, Hokimoto Y, Ohnishi M, Inoue A, Tanaka T, Kaneo Y.  Amphotericin B nanohydrogel ocular formulation using alkyl glyceryl hyaluronic acid: Formulation, characterization, and in vitro evaluation  Int J Pharm  2021  610:121061  PubMed ID: 34481008   DOI: 10.1016/j.ijpharm.2021.121061
16671  Yamashiro C, Tokuda K, Kobayashi Y, Higashijima F, Yoshimoto T, Ota M, Ogata T, Ashimori A, Kobayashi M, Hatano M, Uchi SH, Wakuta M, Teranishi S, Kimura K.  Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10  Sci Rep  2021  11(1):16096  PubMed ID: 34373467   DOI: 10.1038/s41598-021-94852-8
16672  Kang WS, Choi H, Lee KH, Kim E, Kim KJ, Kim JS, Na CS, Kim S.  Peucedanum japonicum Thunberg and Its Active Components Mitigate Oxidative Stress, Inflammation and Apoptosis after Urban Particulate Matter-Induced Ocular Surface Damage  Antioxidants (Basel)  2021  10(11):1717.  PubMed ID: 34829588   DOI: 10.3390/antiox10111717
16673  Bianchini G, Tomassetti M, Lillini S, Sirico A, Bovolenta S, Za L, Liberati C, Novelli R, Aramini A.  Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p Ka and LogD Modulation  J Med Chem  2021  64(22):16820-16837  PubMed ID: 34762442   DOI: 10.1021/acs.jmedchem.1c01647
16789  Wang S, Hou F, Yao YF, Pan D.  Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication  Virology  2021  556:140-148  PubMed ID: 33631413   DOI: 10.1016/j.virol.2021.01.016
6967  Seino S1,, Matsuoka R, Masuda Y, Kunou M, Okada Y, Saika S.  Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing.  Cutan Ocul Toxicol  2020  39(1):13-20  PubMed ID: 31588814   DOI: 10.1080/15569527.2019.1673402
11893  Vitoux MA, Kessal K, Melik Parsadaniantz S, Claret M, Guerin C, Baudouin C, Brignole-Baudouin F, Réaux-Le Goazigo A.  Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro.  Toxicol. Lett.  2020    PubMed ID: 31707104   DOI: 10.1016/j.toxlet.2019.10.014
11963  Jurišić Dukovski B, Juretić M, Bračko D, Randjelović D, Savić S, Crespo Moral M, Diebold Y, Filipović-Grčić J, Pepić I, Lovrić J.  Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment.  Int J Pharm  2020    PubMed ID: 31870964   DOI: 10.1016/j.ijpharm.2019.118979
11983  Zeng W, Zhang Y, Duan F, Lin T, Liu X, Li D, Wu K.  Lipopolysaccharide enhances human herpesvirus 1 replication and IL-6 release in epithelial cells.  Microb. Pathog.  2020    PubMed ID: 31904451   DOI: 10.1016/j.micpath.2019.103961
11998  Rubelowski AK, Latta L, Katiyar P, Stachon T, Käsmann-Kellner B, Seitz B, Szentmáry N.  HCE-T cell line lacks cornea-specific differentiation markers compared to primary limbal epithelial cells and differentiated corneal epithelium.  Graefes Arch. Clin. Exp. Ophthalmol.  2020    PubMed ID: 31927639   DOI: 10.1007/s00417-019-04563-0
12024  Fu R, Guo H, Janga S, Choi M, Klinngam W, Edman MC, Hamm-Alvarez SF.  Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model.  Sci Rep  2020  10(1):1455  PubMed ID: 31996771   DOI: 10.1038/s41598-020-58337-4
12145  Davood Kharaghani, Debarun Dutta, Kitty K. K. Ho, Ke-Qin Zhang, Wei Kai, Xuehong Ren, Mark D. P. Willcox & Ick Soo Kim  Active loading graphite/hydroxyapatite into the stable hydroxyethyl cellulose scaffold nanofibers for artificial cornea application  Original Research  2020      DOI: 10.1007/s10570-020-02999-w
12173  Pierre-Louis Destruel,Ni Zeng, Françoise Brignole-Baudouin,Sophie Douat, Johanne Seguin, Elodie Olivier, Melody Dutot, ,Patrice Rat, Sophie Dufaÿ, Amélie Dufaÿ-Wojcicki, Marc Maury, Nathalie Mignet, * andVincent Boudy,   In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics  Pharmaceutics  2020    PubMed ID: 32326492   DOI: 10.3390/pharmaceutics12040360
12965  Kabashima K, Murakami A, Ebihara N.  Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells.  J Ocul Pharmacol Ther  2020    PubMed ID: 32552267   DOI: 10.1089/jop.2019.0165
12993  Matsuda Y, Machida M, Nakagami Y, Nakajima T, Azuma M.  NFE2L2 activator RS9 protects against corneal epithelial cell damage in dry eye models.  PLoS One  2020    PubMed ID: 32320433   DOI: 10.1371/journal.pone.0229421
13118  Kiss EL, Berkó S, Gácsi A, Kovács A, Katona G, Soós J, Csányi E, Gróf I, Harazin A, Deli MA, Balogh GT, Budai-Szűcs M.  Development and Characterization of Potential Ocular Mucoadhesive Nano Lipid Carriers Using Full Factorial Design.  Pharmaceutics  2020    PubMed ID: 32698334   DOI: 10.3390/pharmaceutics12070682
13271  Xu M, Sivak JG, McCanna DJ.  Ocular toxicology: synergism of UV radiation and benzalkonium chloride.  Cutan Ocul Toxicol  2020    PubMed ID: 33019823   DOI: 10.1080/15569527.2020.1833027
13318  Inaba K, Minami M, Yamaguchi M, Goto R, Otake H, Kotake T, Nagai N.  Effects of the Ophthalmic Additive Mannitol on Antimicrobial Activity and Corneal Toxicity of Various Preservatives.  Chem Pharm Bull (Tokyo)  2020    PubMed ID: 33132373   DOI: 10.1248/cpb.c20-00540
13339  Kashiwagi K, Iizuka Y.  Effect and underlying mechanisms of airborne particulate matter 2.5 (PM2.5) on cultured human corneal epithelial cells.  Sci Rep  2020    PubMed ID: 33177636   DOI: 10.1038/s41598-020-76651-9
13397  Frazer H, You J, Chen Z, Sayyar S, Liu X, Taylor A, Hodge C, Wallace G, Sutton G.  Development of a Platelet Lysate-Based Printable, Transparent Biomaterial With Regenerative Potential for Epithelial Corneal Injuries.  Transl Vis Sci Technol  2020    PubMed ID: 33442494   DOI: 10.1167/tvst.9.13.40
13425  Emi Ooe, Tomohiro Yako, Yoshiki Kuse, Tetsuya Sogon, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara  The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells  Journal of Nutritional Food  2020      DOI: 10.20618/jhnfa.17.1_18
13569  He H, Liang M, Li L, Luo S, Fang X, He H, Xiao X, Wu H, Lin Z.  PPAR-α Agonist Fenofibrate Suppressed the Formation of Ocular Surface Squamous Metaplasia Induced by Topical Benzalkonium Chloride  Invest Ophthalmol Vis Sci  2020  61(3):54  PubMed ID: 32232349   DOI: 10.1167/iovs.61.3.54
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13848  Kyung-A Kim, Chung Hyun Lee, Tae Kyeom Kang, Sung Jae Yang, Chang Yong Lee, Wook-Bin Lee & Sang Hoon Jung   Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model  Applied Biological Chemistry   2020  63    DOI: 10.1186/s13765-020-00529-7
13904  Xu LJ, Rong SS, Xu YS, Zheng LB, Qiu WY, Zhang X, Jiang LJ, Duan RP, Tian T, Yao YF.  Anti-fibrosis potential of pirarubicin via inducing apoptotic and autophagic cell death in rabbit conjunctiva  Exp Eye Res  2020  200:108215  PubMed ID: 32896532   DOI: 10.1016/j.exer.2020.108215
13928  Chen SY, Xie C, Zhu H, Shen Y.  Effects of epidermal growth factor on transforming growth factor-beta1-induced epithelial-mesenchymal transition and potential mechanism in human corneal epithelial cells  Int J Ophthalmol  2020  13(1):11-20  PubMed ID: 31956565   DOI: 10.18240/ijo.2020.01.03
14864  Zambrano-Andazol I, Vázquez N, Chacón M, Sánchez-Avila RM, Persinal M, Blanco C, González Z, Menéndez R, Sierra M, Fernández-Vega Á, Sánchez T, Merayo-Lloves J, Meana Á.  Reduced graphene oxide membranes in ocular regenerative medicine  Mater Sci Eng C Mater Biol Appl  2020  114:111075  PubMed ID: 32993970   DOI: 10.1016/j.msec.2020.111075
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12973  Zong R, Zhou T, Lin Z, Bao X, Xiu Y, Chen Y, Chen L, Ma JX, Liu Z, Zhou Y.  Down-Regulation of MicroRNA-184 Is Associated With Corneal Neovascularization  Invest Ophthalmol Vis Sci  2016  57(3):1398-407  PubMed ID: 27018842   DOI: 10.1167/iovs.15-17417
14107  Iqbal J, Saeed A, Shah SJ, al-Rashida M, Shams-ul Mahmood.  Biological Evaluation of Azomethine-dihydroquinazolinone Conjugates as Cancer and Cholinesterase Inhibitors  Med Chem  2016  12(1):74-82  PubMed ID: 26152145   DOI: 10.2174/1573406411666150708111417
14580  Chen Y, Yang W, Zhang X, Yang S, Peng G, Wu T, Zhou Y, Huang C, Reinach PS, Li W, Liu Z.  MK2 inhibitor reduces alkali burn-induced inflammation in rat cornea  Sci Rep  2016  6:28145  PubMed ID: 27329698   DOI: 10.1038/srep28145
14582  Kokado M, Okada Y, Miyamoto T, Yamanaka O, Saika S.  Effects of epiplakin-knockdown in cultured corneal epithelial cells  BMC Res Notes  2016  9:278  PubMed ID: 27206504   DOI: 10.1186/s13104-016-2082-7
11651  Hogerheyde TA, Suzuki S, Walshe J, Bray LJ, Stephenson SA, Harkin DG, Richardson NA.  Optimization of Corneal Epithelial Progenitor Cell Growth on Bombyx mori Silk Fibroin Membranes  Stem Cells Int  2016  2016:8310127  PubMed ID: 27648078   DOI: 10.1155/2016/8310127
16661  Romaniuk D, Smagur J, Cisek A, Antonik J, Romaniuk W.  Does preservative content affect drug permeability? The permeability analysis in vitro of 3 ophthalmic Latanoprost formulations in a human epithelial cell culture model  Klin Oczna  2016  118(2):127-32  PubMed ID: 29912495  
16690  Mehra NK, Cai D, Kuo L, Hein T, Palakurthi S.  Safety and toxicity of nanomaterials for ocular drug delivery applications  Nanotoxicology  2016  10(7):836-60.  PubMed ID: 27027670   DOI: 10.3109/17435390.2016.1153165
7396  Hafner A, Lovri? J, Romi? MD, Jureti? M, Pepi? I, Cetina-?i?mek B, Filipovi?-Gr?i? J.  Evaluation of cationic nanosystems with melatonin using an eye-related bioavailability prediction model.  Eur J Pharm Sci  2015  75:142-50  PubMed ID: 25869457   DOI: 10.1016/j.ejps.2015.04.003
7500  Verstraelen J, Reichl S.  Upregulation of P-glycoprotein expression by ophthalmic drugs in different corneal in-vitro models.  J. Pharm. Pharmacol.  2015  67:605-15  PubMed ID: 25643948   DOI: 10.1111/jphp.12357
6337  Xu M, McCanna DJ, Sivak JG.  Use of the viability reagent PrestoBlue in comparison with alamarBlue and MTT to assess the viability of human corneal epithelial cells.  J Pharmacol Toxicol Methods  2015  71:1-7  PubMed ID: 25464019   DOI: 10.1016/j.vascn.2014.11.003
15032  Pretor S, Bartels J, Lorenz T, Dahl K, Finke JH, Peterat G, Krull R, Al-Halhouli AT, Dietzel A, Büttgenbach S, Behrends S, Reichl S, Müller-Goymann CC.  Cellular uptake of coumarin-6 under microfluidic conditions into HCE-T cells from nanoscale formulations  Mol Pharm  2015  12(1):34-45  PubMed ID: 25412253   DOI: 10.1021/mp500401t
15065  Arooj S, Nazir S, Nadhman A, Ahmad N, Muhammad B, Ahmad I, Mazhar K, Abbasi R.  Novel ZnO:Ag nanocomposites induce significant oxidative stress in human fibroblast malignant melanoma (Ht144) cells  Beilstein J Nanotechnol   2015  6:570-82  PubMed ID: 25821698   DOI: 10.3762/bjnano.6.59
15242  Sirajuddin M, Ali S, McKee V, Ullah H.  Synthesis, spectroscopic characterization and in vitro antimicrobial, anticancer and antileishmanial activities as well interaction with Salmon sperm DNA of newly synthesized carboxylic acid derivative, 4-(4-methoxy-2-nitrophenylamino)-4-oxobutanoic acid  Spectrochim Acta A Mol Biomol Spectrosc  2015  138:569-78  PubMed ID: 25536453   DOI: 10.1016/j.saa.2014.11.061
15480  Chen L, Zong R, Zhou J, Ge L, Zhou T, Ma JX, Liu Z, Zhou Y.  The oxidant role of 4-hydroxynonenal in corneal epithelium  Sci Rep  2015  5:10630  PubMed ID: 26023743   DOI: 10.1038/srep10630
15505  Bartok M, Gabel D, Zorn-Kruppa M, Engelke M.  Development of an in vitro ocular test system for the prediction of all three GHS categories  Toxicol In Vitro  2015  29(1):72-80  PubMed ID: 25260822   DOI: 10.1016/j.tiv.2014.09.005
6330  Shibata Y, Tanaka Y, Tomita T, Taogoshi T, Kimura Y, Chikama T, Kihira K.  Evaluation of corneal damage caused by iodine preparations using human corneal epithelial cells.  Jpn J Ophthalmol  2014  58(6):522-7  PubMed ID: 25230910   DOI: 10.1007/s10384-014-0348-y
6332  Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay JA.  Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles.  J Mater Chem B  2014  2(46):8131-8141  PubMed ID: 25530855   DOI: 10.1039/C4TB00979G
6357  Wen L, Zhu M, Madigan MC, You J, King NJ, Billson FA, McClellan K, Sutton G, Petsoglou C2  Immunomodulatory effects of bone marrow-derived mesenchymal stem cells on pro-inflammatory cytokine-stimulated human corneal epithelial cells.  PLoS One.  2014  9(7):e101841  PubMed ID: 25003339   DOI: 10.1371/journal.pone.0101841
6358  Sharma S, Gupta D, Mohanty S, Jassal M, Agrawal AK, Tandon R.  Surface-modified electrospun poly(epsilon-caprolactone) scaffold with improved optical transparency and bioactivity for damaged ocular surface reconstruction.  Invest Ophthalmol Vis Sci  2014  55(2):899-907  PubMed ID: 24425860   DOI: 10.1167/iovs.13-12727
6359  Mahita Kadmiel, John A Cidlowski  Functional Characterization of the Glucocorticoid Receptor in the Cornea  Investigative Ophthalmology & Visual Science  2014  55:5504   
6360  Anitua E, Muruzabal F, De la Fuente M, Merayo-Lloves J, Orive G.  Effects of heat-treatment on plasma rich in growth factors-derived autologous eye drop.  Exp Eye Res  2014  119:27-34  PubMed ID: 24345372   DOI: 10.1016/j.exer.2013.12.005
15099  Zorn-Kruppa M, Houdek P, Wladykowski E, Engelke M, Bartok M, Mewes KR, Moll I, Brandner JM.  Determining the Depth of Injury in Bioengineered Tissue Models of Cornea and Conjunctiva for the Prediction of All Three Ocular GHS Categories  PLoS One  2014  9(12):e114181  PubMed ID: 25494045   DOI: 10.1371/journal.pone.0114181
15833  Ko JA, Mizuno Y, Ohki C, Chikama T, Sonoda KH, Kiuchi Y.  Neuropeptides released from trigeminal neurons promote the stratification of human corneal epithelial cells  Invest Ophthalmol Vis Sci  2014  55(1):125-33  PubMed ID: 24327615   DOI: 10.1167/iovs.13-12642
15995  Friedrich Erben, Dirk Michalik, Holger Feist, Dennis Kleeblatt, Martin Hein, Abdul Matin, Jamshed Iqbal, Peter Langer  Synthesis and antiproliferative activity of (Z)-1-glycosyl-3-(5-oxo-2-thioxoimidazolidin-4-ylidene)indolin-2-ones and (Z)-3-(2-glycosylsulfanyl-4-oxo-4,5-dihydro-thiazol-5-ylidene)indolin-2-ones  RSC Advances  2014  4:10879    DOI: 10.1039/c3ra44362k
16002  Wright B, De Bank PA, Luetchford KA, Acosta FR, Connon CJ.  Oxidized alginate hydrogels as niche environments for corneal epithelial cells  J Biomed Mater Res A  2014  102(10):3393-400  PubMed ID: 24142706   DOI: 10.1002/jbm.a.35011
6364  Wang N, Zimmerman K, Raab RW, McKown RL, Hutnik CM, Talla V, Tyler MF 4th, Lee JK, Laurie GW.  Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.  J Biol Chem.  2013.  288(25):18146-61  PubMed ID: 23640897   DOI: 10.1074/jbc.M112.436584
19070  Sasaki H, Karasawa K, Hironaka K, Tahara K, Tozuka Y, Takeuchi H.  Retinal drug delivery using eyedrop preparations of poly-L-lysine-modified liposomes  Eur J Pharm Biopharm  2013  83(3):364-9.  PubMed ID: 23153668   DOI: 10.1016/j.ejpb.2012.10.014
6323  Xu M, Sivak JG, McCanna DJ.  Comparison of the effects of ophthalmic solutions on human corneal epithelial cells using fluorescent dyes.  J Ocul Pharmacol Ther  2013  29(9):794-802  PubMed ID: 23905770   DOI: 10.1089/jop.2013.0002
6324  Yamaguchi H, Kojima H, Takezawa T.  Vitrigel-eye irritancy test method using HCE-T cells.  Toxicol Sci  2013  135(2):347-55  PubMed ID: 23872712   DOI: 10.1093/toxsci/kft159
6325  Rahimi M, Youn HY, McCanna DJ, Sivak JG, Mikkelsen SR.  Application of cyclic biamperometry to viability and cytotoxicity assessment in human corneal epithelial cells.  Anal Bioanal Chem  2013  405(14):4975-9  PubMed ID: 23443523   DOI: 10.1007/s00216-013-6843-z
6327  Tong L, Png E, Aihua H, Yong SS, Yeo HL, Riau A, Mendoz E, Chaurasia SS, Lim CT, Yiu TW, Iismaa SE.  Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion.  Biochim Biophys Acta.  2013  1833(6):1304-15  PubMed ID: 23466867   DOI: 10.1016/j.bbamcr.2013.02.030
6328  Hiroyoshi Kasai et al  Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride  Pharmacology & Pharmacy   2013  4:377-384    DOI: 10.4236/pp.2013.44054
6361  Verstraelen J, Reichl S.  Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies.  Int J Pharm  2013  441(1-2):765-75  PubMed ID: 23069916   DOI: 10.1016/j.ijpharm.2012.10.007
6362  Borrelli M, Reichl S, Feng Y, Schargus M, Schrader S, Geerling G.  In vitro characterization and ex vivo surgical evaluation of human hair keratin films in ocular surface reconstruction after sterilization processing.  J Mater Sci Mater Med  2013  24(1):221-30  PubMed ID: 23015265   DOI: 10.1007/s10856-012-4774-4
6363  Hogerheyde TA, Stephenson SA, Harkin DG, Bray LJ, Madden PW, Woolf MI, Richardson NA.  Evaluation of Eph receptor and ephrin expression within the human cornea and limbus.  Exp Eye Res  2013  107:110-20  PubMed ID: 23247085   DOI: 10.1016/j.exer.2012.11.016
6365  Raju R, Jian B, Hooks JJ, Nagineni CN.  Transforming growth factor-β regulates the expression of anosmin (KAL-1) in human retinal pigment epithelial cells.  Cytokine  2013  61(3):724-7  PubMed ID: 23357298   DOI: 10.1016/j.cyto.2012.12.019
6333  George KA, Shadforth AM, Chirila TV, Laurent MJ, Stephenson SA, Edwards GA, Madden PW, Hutmacher DW, Harkin DG.  Effect of the sterilization method on the properties of Bombyx mori silk fibroin films.  Mater Sci Eng C Mater Biol Appl  2013  33(2):668-74  PubMed ID: 25427472   DOI: 10.1016/j.msec.2012.10.016
6366  Anitua E, Muruzabal F, Alcalde I, Merayo-Lloves J, Orive G.  Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery.  Exp Eye Res  2013  115:153-61  PubMed ID: 23872360   DOI: 10.1016/j.exer.2013.07.007
6367  Paterson SM, Shadforth AM, Shaw JA, Brown DH, Chirila TV, Baker MV.  Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: the use of copolymerization as a means to functionalize PHEMA sponges.  Mater Sci Eng C Mater Biol Appl  2013  33(8):4917-22  PubMed ID: 24094205   DOI: 10.1016/j.msec.2013.08.011
6368  Engelke M, Zorn-Kruppa M, Gabel D, Reisinger K, Rusche B, Mewes KR.  A human hemi-cornea model for eye irritation testing: quality control of production, reliability and predictive capacity.  Toxicol In Vitro  2013  27(1):458-68  PubMed ID: 22902307   DOI: 10.1016/j.tiv.2012.07.011
14321  Dutot M, Vincent J, Martin-Brisac N, Fabre I, Grasmick C, Rat P.  Ocular cytotoxicity evaluation of medical devices such as contact lens solutions and benefits of a rinse step in cleaning procedure  ALTEX  2013  30(1):41-9.  PubMed ID: 23338805   DOI: 10.14573/altex.2013.1.041
15778  Fukuda K, Ishida W, Tanaka H, Harada Y, Matsuda A, Ebihara N, Fukushima A.  Alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts  Invest Ophthalmol Vis Sci  2013  54(8):5817-23  PubMed ID: 23920370   DOI: 10.1167/iovs.13-11969
15787  Guo H, Du G, Wang L, Wang D, Hu L, Huang Y.  Integrin alpha v beta 6 contributes to maintaining corneal epithelial barrier function  Cell Biol Int  2013  37(6):593-9  PubMed ID: 23412966   DOI: 10.1002/cbin.10076
15934  Hafiz Muhammad Shoaib 1 , Ambreen Gul Muazzam, Asif Mir, Suk-Yul Jung, Abdul Matin  Evaluation of inhibitory potential of some selective methanolic plants extracts on biological characteristics of Acanthamoeba castellanii using human corneal epithelial cells in vitro  Parasitol Res  2013  112(3):1179-88  PubMed ID: 23306385   DOI: 10.1007/s00436-012-3249-3
16088  Iqbal J, Saeed A, Raza R, Matin A, Hameed A, Furtmann N, Lecka J, Sévigny J, Bajorath J.  Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors  Eur J Med Chem  2013  70:685-91  PubMed ID: 24215819   DOI: 10.1016/j.ejmech.2013.10.053
6315  Liang H, Baudouin C, Daull P, Garrigue JS, Brignole-Baudouin F.  Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit model.  Mol Vis  2012  18:2195-204  PubMed ID: 22919267  
6369  Hattori M, Shimizu K, Katsumura K, Oku H, Sano Y, Matsumoto K, Yamaguchi Y, Ikeda T.  Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing.  Graefes Arch Clin Exp Ophthalmol  2012  250(4):557-63  PubMed ID: 22048243   DOI: 10.1007/s00417-011-1849-8
6370  Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K.  Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).  Trans Am Ophthalmol Soc  2012  110:166-77  PubMed ID: 23818740  
6371  Hahne M, Zorn-Kruppa M, Guzman G, Brandner JM, Haltner-Ukomado E, Wätzig H, Reichl S.  Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies.  J Pharm Sci  2012  101(8):2976-88  PubMed ID: 22581751   DOI: 10.1002/jps.23190
6372  Stefan M.Paterson et al  The synthesis and degradation of collagenase-degradable poly(2-hydroxyethyl methacrylate)-based hydrogels and sponges for potential applications as scaffolds in tissue engineering  Materials Science and Engineering: C   2012  32:2536-2544    DOI: 10.1016/j.msec.2012.07.037
9093  Bernice Wright, Richard A Cave, Joseph P Cook, Vitaliy V Khutoryanskiy, Shengli Mi, Bo Chen, Martin Leyland, Che J Connon  Enhanced Viability of Corneal Epithelial Cells for Efficient Transport/Storage Using a Structurally Modified Calcium Alginate Hydrogel  Regen Med2  2012  7 (3), 295-307  PubMed ID: 22594324   DOI: 10.2217/rme.12.7
15761  Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, Liu Z, He H, Ma JX, Liu Z, Zhou Y.  SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium  Invest Ophthalmol Vis Sci  2012  53(8):5033-43  PubMed ID: 22736614   DOI: 10.1167/iovs.12-9729
16034  Shinya Hattori, Dohiko Terada, Andreana Bibin Bintang, Takako Honda, Chiaki Yoshikawa, Hidetoshi Teramoto, Tsunenori Kameda, Tamada Yasushi, Hisatoshi Kobayashi  Influence of sterilisations on silk protein-based materials  Bioinspired, Biomimetic and Nanobiomaterials  2012  1:195-199    DOI: 10.1680/bbn.11.00006
7623  Sharma S, Mohanty S, Gupta D, Jassal M, Agrawal AK, Tandon R.  Cellular response of limbal epithelial cells on electrospun poly-ε-caprolactone nanofibrous scaffolds for ocular surface bioengineering: a preliminary in vitro study.  Mol. Vis.  2011  17:2898-910  PubMed ID: 22128237  
7815  Kato M, Hagiwara Y, Oda T, Imamura-Takai M, Aono H, Nakamura M.  Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.  J Ocul Pharmacol Ther  2011  27:353-60  PubMed ID: 21574866   DOI: 10.1089/jop.2010.0177
7894  Png E, Lan W, Lazaroo M, Chen S, Zhou L, Tong L.  A new method of high-speed cellular protein separation and insight into subcellular compartmentalization of proteins.  Anal Bioanal Chem  2011  400:767-75  PubMed ID: 21380751   DOI: 10.1007/s00216-011-4810-0
7974  Youn HY, McCanna DJ, Sivak JG, Jones LW.  In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells.  Mol. Vis.  2011  17:237-46  PubMed ID: 21270970  
8152  Png E, Samivelu GK, Yeo SH, Chew J, Chaurasia SS, Tong L.  Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells.  J. Cell. Physiol.  2011  226:693-9  PubMed ID: 20717931   DOI: 10.1002/jcp.22389
6311  Takezawa T, Nishikawa K, Wang PC.  Development of a human corneal epithelium model utilizing a collagen vitrigel membrane and the changes of its barrier function induced by exposing eye irritant chemicals.  Toxicol In Vitro  2011  25(6):1237-41  PubMed ID: 21641988   DOI: 10.1016/j.tiv.2011.05.021
12746  Kimura K, Teranishi S, Kawamoto K, Nishida T.  Protective effect of dexamethasone against hypoxia-induced disruption of barrier function in human corneal epithelial cells  Exp Eye Res  2011  92(5):388-93  PubMed ID: 21354133   DOI: 10.1016/j.exer.2011.02.013
15712  Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, Ma JX, Liu Z, Zhou Y.  Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury  PLoS One  2011  6(1):e16712  PubMed ID: 21304961   DOI: 10.1371/journal.pone.0016712
16306  Kimura K, Teranishi S, Orita T, Zhou H, Nishida T.  Role of β-Pix in corneal epithelial cell migration on fibronectin  Invest Ophthalmol Vis Sci  2011  52(6):3181-6  PubMed ID: 21228382   DOI: 10.1167/iovs.10-5684
8041  Shah A, Farooq AV, Tiwari V, Kim MJ, Shukla D.  HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection.  Mol. Vis.  2010  16:2476-86  PubMed ID: 21139972  
6374  Yamada T, Ueda T, Ugawa S, Ishida Y, Imayasu M, Koyama S, Shimada S.  Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.  Exp Eye Res  2010  90(1):121-9  PubMed ID: 19793539   DOI: 10.1016/j.exer.2009.09.020
9081  Yuki Terasaka, Dai Miyazaki, Keiko Yakura, Tomoko Haruki, Yoshitsugu Inoue  Induction of IL-6 in Transcriptional Networks in Corneal Epithelial Cells After Herpes Simplex Virus Type 1 Infection  Invest Ophthalmol Vis Sci  2010  51 (5), 2441-9  PubMed ID: 20019363   DOI: 10.1167/iovs.09-4624
12758  Kimura K, Teranishi S, Kawamoto K, Nishida T.  Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by hepatocyte growth factor  Exp Eye Res  2010  90(2):337-43  PubMed ID: 19944686   DOI: 10.1016/j.exer.2009.11.012
15696  Kimura K, Kawano S, Mori T, Inoue J, Hadachi H, Saito T, Nishida T.  Quantitative analysis of the effects of extracellular matrix proteins on membrane dynamics associated with corneal epithelial cell motility  Invest Ophthalmol Vis Sci   2010  51(9):4492-9  PubMed ID: 20357207   DOI: 10.1167/iovs.09-4380
16663  Imayasu M, Hori Y, Cavanagh HD.  Effects of multipurpose contact lens care solutions and their ingredients on membrane-associated mucins of human corneal epithelial cells  Eye Contact Lens  2010  36(6):361-6  PubMed ID: 21060261   DOI: 10.1097/ICL.0b013e3181faa43e
11686  Kimura K, Teranishi S, Nishida T.  Establishment of human corneal epithelial cells stably expressing human connexin43  Exp Eye Res  2010  90(1):4-9  PubMed ID: 19799899   DOI: 10.1016/j.exer.2009.09.002
8445  Dutot M, Liang H, Martin C, Rousseau D, Grynberg A, Warnet JM, Rat P.  Per os administered refined olive oil and marine PUFA-rich oils reach the cornea: possible role on oxidative stress through caveolin-1 modulation.  Nutr Metab (Lond)  2009  6:48  PubMed ID: 19930652   DOI: 10.1186/1743-7075-6-48
8502  Pauloin T, Dutot M, Liang H, Chavinier E, Warnet JM, Rat P.  Corneal protection with high-molecular-weight hyaluronan against in vitro and in vivo sodium lauryl sulfate-induced toxic effects.  Cornea  2009  28:1032-41  PubMed ID: 19724206   DOI: 10.1097/ICO.0b013e3181a0a3f8
8624  Pauloin T, Dutot M, Joly F, Warnet JM, Rat P.  High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.  Mol. Vis.  2009  15:577-83  PubMed ID: 19325714  
8697  Liu L, Tiffany J, Dang Z, Dart JK, Watson SL, Daniels JT, Geerling G.  Nourish and nurture: development of a nutrient ocular lubricant.  Invest. Ophthalmol. Vis. Sci.  2009  50:2932-9  PubMed ID: 19074805   DOI: 10.1167/iovs.08-1991
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6376  Karla PK, Quinn TL, Herndon BL, Thomas P, Pal D, Mitra A.  Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.  J Ocul Pharmacol Ther  2009  25(2):121-32  PubMed ID: 19323627   DOI: 10.1089/jop.2008.0084
9077  Kozaburo Hayashi, Laura C Hooper, Barbara Detrick, John J Hooks  HSV Immune Complex (HSV-IgG: IC) and HSV-DNA Elicit the Production of Angiogenic Factor VEGF and MMP-9  Arch Virol  2009  154 (2), 219-26  PubMed ID: 19115032   DOI: 10.1007/s00705-008-0303-7
12767  Kimura K, Teranishi S, Nishida T.  Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells  Invest Ophthalmol Vis Sci  2009  50(2):597-603  PubMed ID: 19171646   DOI: 10.1167/iovs.08-2606
16691  Ko JA, Yanai R, Nishida T.  Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P  FEBS Lett  2009  583(12):2148-53  PubMed ID: 19446555   DOI: 10.1016/j.febslet.2009.05.010
16694  Teranishi S, Kimura K, Nishida T.  Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro  Invest Ophthalmol Vis Sci  2009  50(12):5646-52  PubMed ID: 19494198   DOI: 10.1167/iovs.08-2534
18249  Teranishi S, Kimura K, Kawamoto K, Nishida T.  Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by keratinocyte growth factor  Invest Ophthalmol Vis Sci  2008  49(6):2432-7  PubMed ID: 18362114   DOI: 10.1167/iovs.07-1464
8755  Dutot M, Liang H, Pauloin T, Brignole-Baudouin F, Baudouin C, Warnet JM, Rat P.  Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.  Mol. Vis.  2008  14:889-97  PubMed ID: 18490962  
8777  Alison C. Dunn A Jessica A. Cobb A Ana N. Kantzios A Sung Jin Lee AMalisa Sarntinoranont A Roger Tran-Son-Tay A W. Gregory Sawyer  Friction Coefficient Measurement of Hydrogel Materialson Living Epithelial Cells  Tribology Letters  2008  30:13-19    DOI: 10.1007/s11249-008-9306-5
8783  Cobb JA, Dunn AC, Kwon J, Sarntinoranont M, Sawyer WG, Tran-Son-Tay R.  A novel method for low load friction testing on living cells.  Biotechnol. Lett.  2008  30:801-6  PubMed ID: 18071637   DOI: 10.1007/s10529-007-9623-z
6299  Pauloin T, Dutot M, Warnet JM, Rat P.  In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride.  Eur J Pharm Sci.   2008  34(4-5):263-73  PubMed ID: 18534829   DOI: 10.1016/j.ejps.2008.04.006
6377  Becker U, Ehrhardt C, Schneider M, Muys L, Gross D, Eschmann K, Schaefer UF, Lehr CM.  A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability.  Altern Lab Anim  2008  36(1):33-44  PubMed ID: 18333713   DOI: 10.1177/026119290803600106
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