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Cell No. : Cell Name
RCB2280 : HCE-T  update : 2022/05/30
CommentSV40-Adeno vector transformed cornea cells. 64kD keratin producing. Choleratoxin-free medium. To the users who purchased this cell line for OECD Test Guideline No. 494 (PDF 91KB)
Comment from the depositor
Terms and conditions1) In publishing research results obtained by the use of the BIOLOGICAL RESOURCE, a citation of the literature ref. (Invest Ophthalmol Vis Sci. 1995;36:614-621)
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Araki-Sasaki Kaoru
Originator Araki-Sasaki Kaoru
Year of deposit 2005
Original cell RCB1384
Animal human < Mammals
Genus Homo
Species sapiens
Gender Female
Age at sampling 49 years
Tissue cornea
Disease name maxillary sinus carcinoma
Classification transformed
Recombinant recombinant
Exogene SV40-large T
Memo_1 Mycoplasma was eliminated with MC-210 by the depositor.
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_1272
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM/HamF12 + 5% FBS + 5μg/ml Insulin + 10ng/ml human EGF + 0.5% DMSO
Antibiotics Free
Passage method 0.25% Trypsin or (0.25% Trypsin + 0.02% EDTA) or (0.25% Trypsin + 0.04% EDTA)
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 5
User's Publication 225


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Reference
9981  Araki-Sasaki K, Aizawa S, Hiramoto M, Nakamura M, Iwase O, Nakata K, Sasaki Y, Mano T, Handa H, Tano Y.  Substance P-induced cadherin expression and its signal transduction in a cloned human corneal epithelial cell line.  J Cell Physiol  2000  182(2):189-95  PubMed ID: 10623882   DOI: 10.1002/(SICI)1097-4652(200002)182:2<189::AID-JCP7>3.0.CO;2-9
9980  Saarinen-Savolainen P, Järvinen T, Araki-Sasaki K, Watanabe H, Urtti A. Author information  Evaluation of cytotoxicity of various ophthalmic drugs, eye drop excipients and cyclodextrins in an immortalized human corneal epithelial cell line.  Pharm Res  1998  15(8):1275-80  PubMed ID: 9706061   DOI: 10.1023/a:1011956327987
2263  Araki-Sasaki K, Ohashi Y, Sasabe T, Hayashi K, Watanabe H, Tano Y, Handa H  An SV40-immortalized human corneal epithelial cell line and its characterization.  Invest Ophthalmol Vis Sci  1995  36:614-21  PubMed ID: 7534282  
2262  Zhang Y, Araki-Sasaki K, Handa H, Akhtar, R A  Effect of carbachol on phospholipase C-mediated phosphatidylinositol 4,5-bisphosphate hydrolysis, and its modulation by isoproterenol in rabbit corneal epithelial cells.  Curr Eye Res  1995  14:563-71  PubMed ID: 7587302   DOI: 10.3109/02713689508998403
2261  Araki K, Ohashi Y, Sasabe T, Kinoshita S, Hayashi K, Yang, X Z, Hosaka Y, Aizawa S, Handa H  Immortalization of rabbit corneal epithelial cells by a recombinant SV40-adenovirus vector.  Invest Ophthalmol Vis Sci  1993  34:2665-71  PubMed ID: 7688358  

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User's Publication
15508  Yu Z, Hao R, Du J, Wu X, Chen X, Zhang Y, Li W, Gu Z, Yang H.  A human cornea-on-a-chip for the study of epithelial wound healing by extracellular vesicles  iScience  2022  25(5):104200  PubMed ID: 35479406   DOI: 10.1016/j.isci.2022.104200
20515  Arunachalam D, Ramanathan SM, Menon A, Madhav L, Ramaswamy G, Namperumalsamy VP, Prajna L, Kuppamuthu D.  Expression of immune response genes in human corneal epithelial cells interacting with Aspergillus flavus conidia.  BMC Genomics  2022  23(1):5  PubMed ID: 34983375   DOI: 10.1186/s12864-021-08218-5
20586  Schwab R, Reichl S.  Dexamethasone-loaded keratin films for ocular surface reconstruction.  J Mater Sci Mater Med  2022  33(3):29  PubMed ID: 35244790   DOI: 10.1007/s10856-021-06638-z
16666  Abdalkader R, Kamei KI.  An efficient simplified method for the generation of corneal epithelial cells from human pluripotent stem cells  Hum Cell  2022  35(4):1016-1029  PubMed ID: 35553384   DOI: 10.1007/s13577-022-00713-5
16695  Kanae Moriya, Hisanori Shimizu, Daisuke Kamei, Satoko Handa, Tadanori Sasaki, Yasuhisa Kato  Evaluation of corneal damage caused by the anticancer drug S-1 in human corneal epithelial cells  The Showa University Journal of Medical Sciences  2022  34:27-32    DOI: 10.15369/sujms.34.27
20797  Cai J, Jacob S, Kurupi R, Dalton KM, Coon C, Greninger P, Egan RK, Stein GT, Murchie E, McClanaghan J, Adachi Y, Hirade K, Dozmorov M, Glod J, Boikos SA, Ebi H, Hao H, Caponigro G, Benes CH, Faber AC.  High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition.  Cell Rep  2022  40(4):111095  PubMed ID: 35905710   DOI: 10.1016/j.celrep.2022.111095
20929  Anitua E, Fuente M, Merayo-Lloves J, Muruzabal F.  Optimization of a Plasma Rich in Growth Factors Membrane for the Treatment of Inflammatory Ocular Diseases.  Bioengineering (Basel)  2022  9(10)  PubMed ID: 36290475   DOI: 10.3390/bioengineering9100508
13379  Wu C, Or PW, Chong JIT, Pathirage Don IKK, Lee CHC, Wu K, Yu M, Lam DCC, Yang Y.  Extended Delivery of Pirfenidone with Novel, Soft Contact Lenses In Vitro and In Vivo.  J Ocul Pharmacol Ther  2021  37(2):75-83.  PubMed ID: 33297836   DOI: 10.1089/jop.2020.0058
13392  Lai YH, Lee PY, Lu CY, Liu YR, Wang SC, Liu CC, Chang YC, Chen YH, Su CC, Li CY, Liu PL.  Thrombospondin 1-induced exosomal proteins attenuate hypoxia-induced paraptosis in corneal epithelial cells and promote wound healing.  FASEB J  2021    PubMed ID: 33341997   DOI: 10.1096/fj.202001106RRR
20039  Kaluzhny Y, Klausner M.  In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development.    2021    PubMed ID: 33544359   DOI: 10.1007/s11626-020-00533-7
20091  Xu M, Sivak JG, McCanna DJ.  Neutralization of the eye and skin irritant benzalkonium chloride using UVC radiation.  Cutan Ocul Toxicol  2021  1-7  PubMed ID: 33771058   DOI: 10.1080/15569527.2021.1902339
20140  Furuya K, Wu T, Orimoto A, Sugano E, Tomita H, Kiyono T, Kurose T, Takai Y, Fukuda T.  The transcriptome of wild-type and immortalized corneal epithelial cells.  Sci Data  2021  8(1):126  PubMed ID: 33963195   DOI: 10.1038/s41597-021-00908-9
14367  Dalton KM, Krytska K, Lochmann TL, Sano R, Casey C, D'Aulerio A, Khan QA, Stein Crowther G, Coon C, Cai J, Jacob S, Kurupi R, Hu B, Dozmorov M, Greninger P, Souers AJ, Benes CH, Mossé YP, Faber AC.  Venetoclax-based rational combinations are effective in models of MYCN-amplified neuroblastoma  Mol Cancer Ther  2021    PubMed ID: 34088831   DOI: 10.1158/1535-7163.MCT-20-0710
14518  Bíró T, Bocsik A, Jurišić Dukovski B, Gróf I, Lovrić J, Csóka I, Deli MA, Aigner Z.  New Approach in Ocular Drug Delivery: In vitro and ex vivo Investigation of Cyclodextrin-Containing, Mucoadhesive Eye Drop Formulations  Drug Des Devel Ther  2021  15:351-360  PubMed ID: 33568896   DOI: 10.2147/DDDT.S264745
14702  Račić A, Čalija B, Milić J, Dukovski BJ, Lovrić J, Dobričić V, Micov A, Vuković M, Stepanović-Petrović R, Krajišnik D.  Formulation of olopatadine hydrochloride viscous eye drops - physicochemical, biopharmaceutical and efficacy assessment using in vitro and in vivo approaches  Eur J Pharm Sci  2021  105906  PubMed ID: 34118409   DOI: 10.1016/j.ejps.2021.105906
15098  Agnė Žiniauskaitė, Vytautas Cėpla, Tadas Jelinskas, Romuald Eimont, Artūras Ulčinas, Rūta Aldonytė, Ramūnas Valiokas, Giedrius Kalesnykas, Jenni J. Hakkarainen  Introducing an Efficient In Vitro Cornea Mimetic Model for Testing Drug Permeability  Sci  2021  3:30    DOI: 10.3390/sci3030030
20266  Abdalkader R, Chaleckis R, Wheelock CE, Kamei KI.  Spatiotemporal determination of metabolite activities in the corneal epithelium on a chip.  Exp Eye Res  2021  209:108646  PubMed ID: 34102209   DOI: 10.1016/j.exer.2021.108646
20368  Lin TL, Cheng C, Zeng WT, Duan F, Pei YH, Liu XP, Shang F, Wu KL.  Anti-viral activity of Staphylococcus aureus lysates against herpes simplex virus type-I infection: an in vitro and in vivo study.  Int J Ophthalmol  2021  14(10):1463-1472  PubMed ID: 34667721   DOI: 10.18240/ijo.2021.10.01
15676  Ghosh AK, Thapa R, Hariani HN, Volyanyuk M, Ogle SD, Orloff KA, Ankireddy S, Lai K, Žiniauskaitė A, Stubbs EB Jr, Kalesnykas G, Hakkarainen JJ, Langert KA, Kaja S.  Poly(lactic-co-glycolic acid) Nanoparticles Encapsulating the Prenylated Flavonoid, Xanthohumol, Protect Corneal Epithelial Cells from Dry Eye Disease-Associated Oxidative Stress  Pharmaceutics  2021  13(9):1362  PubMed ID: 34575438   DOI: 10.3390/pharmaceutics13091362
15678  Magny R, Regazzetti A, Kessal K, Baudouin C, Mélik-Parsadaniantz S, Laprévote O, Brignole-Baudouin F, Auzeil N, Roulland E.  Deepening of lipidome annotation by associating cross-metathesis reaction with mass spectrometry: application to an in vitro model of corneal toxicity  Anal Bioanal Chem  2021  413(19):4825-4836  PubMed ID: 34125263   DOI: 10.1007/s00216-021-03438-w
20447  Otsu W, Ishida K, Chinen N, Nakamura S, Shimazawa M, Tsusaki H, Hara H.  Cigarette smoke extract and heated tobacco products promote ferritin cleavage and iron accumulation in human corneal epithelial cells.  Sci Rep  2021  11(1):18555  PubMed ID: 34535730   DOI: 10.1038/s41598-021-97956-3
20505  Goto R, Yamada S, Otake H, Nakazawa Y, Oka M, Yamamoto N, Sasaki H, Nagai N.  Instillation of Ophthalmic Formulation Containing Nilvadipine Nanocrystals Attenuates Lens Opacification in Shumiya Cataract Rats.  Pharmaceutics  2021  13(12)  PubMed ID: 34959281   DOI: 10.3390/pharmaceutics13121999
14734  Arunachalam D, Namperumalsamy VP, Prajna L, Kuppamuthu D.  Human Corneal Epithelial Cells Internalize Aspergillus flavus Spores by Actin-Mediated Endocytosis  Infect Immun  2021  89(6):e00794-20  PubMed ID: 33753415   DOI: 10.1128/IAI.00794-20
11687  Mungroo MR, Tong T, Khan NA, Anuar TS, Maciver SK, Siddiqui R.  Development of anti-acanthamoebic approaches  Int Microbiol  2021  24(3):363-371  PubMed ID: 33754231   DOI: 10.1007/s10123-021-00171-3
16667  Wu C, Or PW, Chong JIT, K Pathirage Don IK, Lee CHC, Wu K, Yu M, Lam DCC, Yang Y.  Controllable release of pirfenidone by polyvinyl alcohol film embedded soft contact lenses in vitro and in vivo  Drug Deliv  2021  28(1):634-641  PubMed ID: 33779455   DOI: 10.1080/10717544.2021.1895911
16669  Banshoya K, Fujita C, Hokimoto Y, Ohnishi M, Inoue A, Tanaka T, Kaneo Y.  Amphotericin B nanohydrogel ocular formulation using alkyl glyceryl hyaluronic acid: Formulation, characterization, and in vitro evaluation  Int J Pharm  2021  610:121061  PubMed ID: 34481008   DOI: 10.1016/j.ijpharm.2021.121061
16671  Yamashiro C, Tokuda K, Kobayashi Y, Higashijima F, Yoshimoto T, Ota M, Ogata T, Ashimori A, Kobayashi M, Hatano M, Uchi SH, Wakuta M, Teranishi S, Kimura K.  Benzalkonium chloride-induced myofibroblastic transdifferentiation of Tenon's capsule fibroblasts is inhibited by coculture with corneal epithelial cells or by interleukin-10  Sci Rep  2021  11(1):16096  PubMed ID: 34373467   DOI: 10.1038/s41598-021-94852-8
16672  Kang WS, Choi H, Lee KH, Kim E, Kim KJ, Kim JS, Na CS, Kim S.  Peucedanum japonicum Thunberg and Its Active Components Mitigate Oxidative Stress, Inflammation and Apoptosis after Urban Particulate Matter-Induced Ocular Surface Damage  Antioxidants (Basel)  2021  10(11):1717.  PubMed ID: 34829588   DOI: 10.3390/antiox10111717
16673  Bianchini G, Tomassetti M, Lillini S, Sirico A, Bovolenta S, Za L, Liberati C, Novelli R, Aramini A.  Discovery of Novel TRPM8 Blockers Suitable for the Treatment of Somatic and Ocular Painful Conditions: A Journey through p Ka and LogD Modulation  J Med Chem  2021  64(22):16820-16837  PubMed ID: 34762442   DOI: 10.1021/acs.jmedchem.1c01647
16789  Wang S, Hou F, Yao YF, Pan D.  Efficient establishment of reactivatable latency by an acyclovir-resistant herpes simplex virus 1 thymidine kinase substitution mutant with reduced neuronal replication  Virology  2021  556:140-148  PubMed ID: 33631413   DOI: 10.1016/j.virol.2021.01.016
6967  Seino S1,, Matsuoka R, Masuda Y, Kunou M, Okada Y, Saika S.  Topical hyaluronan alone promotes corneal epithelial cell migration whereas combination with benzalkonium chloride impairs epithelial wound healing.  Cutan Ocul Toxicol  2020  39(1):13-20  PubMed ID: 31588814   DOI: 10.1080/15569527.2019.1673402
11893  Vitoux MA, Kessal K, Melik Parsadaniantz S, Claret M, Guerin C, Baudouin C, Brignole-Baudouin F, Réaux-Le Goazigo A.  Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro.  Toxicol. Lett.  2020    PubMed ID: 31707104   DOI: 10.1016/j.toxlet.2019.10.014
11963  Jurišić Dukovski B, Juretić M, Bračko D, Randjelović D, Savić S, Crespo Moral M, Diebold Y, Filipović-Grčić J, Pepić I, Lovrić J.  Functional ibuprofen-loaded cationic nanoemulsion: Development and optimization for dry eye disease treatment.  Int J Pharm  2020    PubMed ID: 31870964   DOI: 10.1016/j.ijpharm.2019.118979
11983  Zeng W, Zhang Y, Duan F, Lin T, Liu X, Li D, Wu K.  Lipopolysaccharide enhances human herpesvirus 1 replication and IL-6 release in epithelial cells.  Microb. Pathog.  2020    PubMed ID: 31904451   DOI: 10.1016/j.micpath.2019.103961
11998  Rubelowski AK, Latta L, Katiyar P, Stachon T, Käsmann-Kellner B, Seitz B, Szentmáry N.  HCE-T cell line lacks cornea-specific differentiation markers compared to primary limbal epithelial cells and differentiated corneal epithelium.  Graefes Arch. Clin. Exp. Ophthalmol.  2020    PubMed ID: 31927639   DOI: 10.1007/s00417-019-04563-0
12024  Fu R, Guo H, Janga S, Choi M, Klinngam W, Edman MC, Hamm-Alvarez SF.  Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjögren's syndrome murine model.  Sci Rep  2020  10(1):1455  PubMed ID: 31996771   DOI: 10.1038/s41598-020-58337-4
12145  Davood Kharaghani, Debarun Dutta, Kitty K. K. Ho, Ke-Qin Zhang, Wei Kai, Xuehong Ren, Mark D. P. Willcox & Ick Soo Kim  Active loading graphite/hydroxyapatite into the stable hydroxyethyl cellulose scaffold nanofibers for artificial cornea application  Original Research  2020      DOI: 10.1007/s10570-020-02999-w
12173  Pierre-Louis Destruel,Ni Zeng, Françoise Brignole-Baudouin,Sophie Douat, Johanne Seguin, Elodie Olivier, Melody Dutot, ,Patrice Rat, Sophie Dufaÿ, Amélie Dufaÿ-Wojcicki, Marc Maury, Nathalie Mignet, * andVincent Boudy,   In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics  Pharmaceutics  2020    PubMed ID: 32326492   DOI: 10.3390/pharmaceutics12040360
12965  Kabashima K, Murakami A, Ebihara N.  Effects of Benzalkonium Chloride and Preservative-Free Composition on the Corneal Epithelium Cells.  J Ocul Pharmacol Ther  2020    PubMed ID: 32552267   DOI: 10.1089/jop.2019.0165
12993  Matsuda Y, Machida M, Nakagami Y, Nakajima T, Azuma M.  NFE2L2 activator RS9 protects against corneal epithelial cell damage in dry eye models.  PLoS One  2020    PubMed ID: 32320433   DOI: 10.1371/journal.pone.0229421
13118  Kiss EL, Berkó S, Gácsi A, Kovács A, Katona G, Soós J, Csányi E, Gróf I, Harazin A, Deli MA, Balogh GT, Budai-Szűcs M.  Development and Characterization of Potential Ocular Mucoadhesive Nano Lipid Carriers Using Full Factorial Design.  Pharmaceutics  2020    PubMed ID: 32698334   DOI: 10.3390/pharmaceutics12070682
13271  Xu M, Sivak JG, McCanna DJ.  Ocular toxicology: synergism of UV radiation and benzalkonium chloride.  Cutan Ocul Toxicol  2020    PubMed ID: 33019823   DOI: 10.1080/15569527.2020.1833027
13318  Inaba K, Minami M, Yamaguchi M, Goto R, Otake H, Kotake T, Nagai N.  Effects of the Ophthalmic Additive Mannitol on Antimicrobial Activity and Corneal Toxicity of Various Preservatives.  Chem Pharm Bull (Tokyo)  2020    PubMed ID: 33132373   DOI: 10.1248/cpb.c20-00540
13339  Kashiwagi K, Iizuka Y.  Effect and underlying mechanisms of airborne particulate matter 2.5 (PM2.5) on cultured human corneal epithelial cells.  Sci Rep  2020    PubMed ID: 33177636   DOI: 10.1038/s41598-020-76651-9
13397  Frazer H, You J, Chen Z, Sayyar S, Liu X, Taylor A, Hodge C, Wallace G, Sutton G.  Development of a Platelet Lysate-Based Printable, Transparent Biomaterial With Regenerative Potential for Epithelial Corneal Injuries.  Transl Vis Sci Technol  2020    PubMed ID: 33442494   DOI: 10.1167/tvst.9.13.40
13425  Emi Ooe, Tomohiro Yako, Yoshiki Kuse, Tetsuya Sogon, Shinsuke Nakamura, Masamitsu Shimazawa, Hideaki Hara  The protective effects of bilberry extract and its main constituents against blue light-emitting diode (LED) light-induced damage in human corneal epithelial cells  Journal of Nutritional Food  2020      DOI: 10.20618/jhnfa.17.1_18
13569  He H, Liang M, Li L, Luo S, Fang X, He H, Xiao X, Wu H, Lin Z.  PPAR-α Agonist Fenofibrate Suppressed the Formation of Ocular Surface Squamous Metaplasia Induced by Topical Benzalkonium Chloride  Invest Ophthalmol Vis Sci  2020  61(3):54  PubMed ID: 32232349   DOI: 10.1167/iovs.61.3.54
13617  Abdalkader R, Kamei KI.  Multi-corneal barrier-on-a-chip to recapitulate eye blinking shear stress forces  Lab Chip  2020  20(8):1410-1417  PubMed ID: 32202263   DOI: 10.1039/c9lc01256g
13848  Kyung-A Kim, Chung Hyun Lee, Tae Kyeom Kang, Sung Jae Yang, Chang Yong Lee, Wook-Bin Lee & Sang Hoon Jung   Effect of persimmon leaves (Diospyros kaki) on goblet cell density and inflammation in experimental dry eye model  Applied Biological Chemistry   2020  63    DOI: 10.1186/s13765-020-00529-7
13904  Xu LJ, Rong SS, Xu YS, Zheng LB, Qiu WY, Zhang X, Jiang LJ, Duan RP, Tian T, Yao YF.  Anti-fibrosis potential of pirarubicin via inducing apoptotic and autophagic cell death in rabbit conjunctiva  Exp Eye Res  2020  200:108215  PubMed ID: 32896532   DOI: 10.1016/j.exer.2020.108215
13928  Chen SY, Xie C, Zhu H, Shen Y.  Effects of epidermal growth factor on transforming growth factor-beta1-induced epithelial-mesenchymal transition and potential mechanism in human corneal epithelial cells  Int J Ophthalmol  2020  13(1):11-20  PubMed ID: 31956565   DOI: 10.18240/ijo.2020.01.03
14864  Zambrano-Andazol I, Vázquez N, Chacón M, Sánchez-Avila RM, Persinal M, Blanco C, González Z, Menéndez R, Sierra M, Fernández-Vega Á, Sánchez T, Merayo-Lloves J, Meana Á.  Reduced graphene oxide membranes in ocular regenerative medicine  Mater Sci Eng C Mater Biol Appl  2020  114:111075  PubMed ID: 32993970   DOI: 10.1016/j.msec.2020.111075
14871  Wang G, Chen P, Wang Y, Wang Y, Reinach PS, Xue Y, Liu Z, Li C.  Onion Epithelial Membrane Scaffolds Transfer Corneal Epithelial Layers in Reconstruction Surgery  Adv Healthc Mater  2020  9(14):e2000469  PubMed ID: 32548957   DOI: 10.1002/adhm.202000469
15662  Magny R, Kessal K, Regazzetti A, Ben Yedder A, Baudouin C, Mélik Parsadaniantz S, Brignole-Baudouin F, Laprévote O, Auzeil N.  Lipidomic analysis of epithelial corneal cells following hyperosmolarity and benzalkonium chloride exposure: New insights in dry eye disease  Biochim Biophys Acta Mol Cell Biol Lipids  2020  1865(9):15872  PubMed ID: 32438057   DOI: 10.1016/j.bbalip.2020.158728
16665  Lee C, Edman MC, Laurie GW, Hamm-Alvarez SF, MacKay JA.  Biosynthesized Multivalent Lacritin Peptides Stimulate Exosome Production in Human Corneal Epithelium  Int J Mol Sci  2020  21(17):6157  PubMed ID: 32859014   DOI: 10.3390/ijms21176157
16686  Han Y, Jiang N, Su T, Yang QC, Yan CC, Ye L, Yuan Q, Zhu PW, Li W, Liu ZG, Shao Y.  Netrin-1 promotes epithelium repair in corneal injury  Int J Ophthalmol  2020  13(2):206-212  PubMed ID: 32090028   DOI: 10.18240/ijo.2020.02.02
16688  Yang Y, Huang C, Lin X, Wu Y, Ouyang W, Tang L, Ye S, Wang Y, Li W, Zhang X, Liu Z.  Long-Term Exposure to Urban Particulate Matter on the Ocular Surface and the Incidence of Deleterious Changes in the Cornea, Conjunctiva and Retina in Rats  Int J Mol Sci  2020  21(14):4976  PubMed ID: 32674521   DOI: 10.3390/ijms21144976
16689  Kang WS, Choi H, Jang G, Lee KH, Kim E, Kim KJ, Jeong GY, Kim JS, Na CS, Kim S.  Dry eye induced by exposure to cigarette smoke pollution: An in vivo and in vitro study  Free Radic Biol Med  2020  187-201  PubMed ID: 32320747   DOI: 10.1016/j.freeradbiomed.2020.04.007
11556  Fuwa M, Shimazaki A, Mieda M, Yamashita N, Akaishi T, Taniguchi T, Kato M.  Efficacy and safety of the fixed combinations of tafluprost/timolol and latanoprost/carteolol.  Sci Rep  2019    PubMed ID: 31097790   DOI: 10.1038/s41598-019-44028-2
11595  Koyama S, Narita E, Suzuki Y, Shiina T, Taki M, Shinohara N, Miyakoshi J.  Long-term exposure to a 40-GHz electromagnetic field does not affect genotoxicity or heat shock protein expression in HCE-T or SRA01/04 cells.  J. Radiat. Res.  2019    PubMed ID: 31197350   DOI: 10.1093/jrr/rrz017
11636  Kawata K, Aoki S, Futamata M, Yamamoto-Rikitake M, Nakao I, Enaida H, Toda S.  Mesenchymal cells and fluid flow stimulation synergistically regulate the kinetics of corneal epithelial cells at the air-liquid interface.  Graefes Arch. Clin. Exp. Ophthalmol.  2019    PubMed ID: 31321523   DOI: 10.1007/s00417-019-04422-y
11661  Panita Suwannoi, Mullika Chomnawang, Amolnat Tunsirikongkon, Angsuma Phongphisutthinan, Christel C.Müller-Goymann, Narong Sarisuta  TAT-surface modified acyclovir-loaded albumin nanoparticles as a novel ocular drug delivery system  Journal of Drug Delivery Science and Technology  2019      DOI: 10.1016/j.jddst.2019.05.029
11818  Dukovski BJ, Bračko A, Šare M, Pepić I, Lovrić J.  In vitro evaluation of stearylamine cationic nanoemulsions for improved ocular drug delivery.  Acta Pharm  2019    PubMed ID: 31639085   DOI: 10.2478/acph-2019-0054
6948  Tong L, Matsuura E, Takahashi M, Nagano T, Kawazu K.  Effects of Anti-Glaucoma Prostaglandin Ophthalmic Solutions on Cultured Human Corneal Epithelial Cells.  Curr Eye Res  2019  44(8):856-862  PubMed ID: 30884982   DOI: 10.1080/02713683.2019.1597127
6970  Kazuyo Sadamoto, Shingo Nemoto, Akio Kawamura, Masaaki Kurata  Comparison of cytotoxicity between fixed- and unfixed-combination ophthalmic solutions in vitro  Fundamental Toxicological Sciences  2019  6:245-248    DOI: 10.2131/fts.6.245
9139  Guoliang Wang, Yuhua Xue, Yanzi Wang, Fei Dong, Mei Shen, Rongrong Zong, Zuguo Liu, Cheng Li   The Role of Autophagy in the Pathogenesis of Exposure Keratitis  J Cell Mol Med  2019  23 (6), 4217-4228  PubMed ID: 30973208   DOI: 10.1111/jcmm.14310
10688  Noriko Yaekashiwa, Hisa Yoshida, Sato Otsuki, Shin’ichiro Hayashi and Kodo Kawase  Verification of Non-thermal Effects of 0.3–0.6 THz-Waves on Human Cultured Cells  Photonics  2019  6(1):33    DOI: 10.3390/photonics6010033
11956  L Kiss E, Berkó S, Gácsi A, Kovács A, Katona G, Soós J, Csányi E, Gróf I, Harazin A, Deli MA, Budai-Szűcs M.  Design and Optimization of Nanostructured Lipid Carrier Containing Dexamethasone for Ophthalmic Use.  Pharmaceutics  2019    PubMed ID: 31847336   DOI: 10.3390/pharmaceutics11120679
12325  Zorzi GK, Schuh RS, Maschio VJ, Brazil NT, Rott MB, Teixeira HF.  Box Behnken design of siRNA-loaded liposomes for the treatment of a murine model of ocular keratitis caused by Acanthamoeba  Colloids Surf B Biointerfaces  2019  173:725-732.  PubMed ID: 30384269   DOI: 10.1016/j.colsurfb.2018.10.044
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12417  Zhang X, Yin Y, Yue L, Gong L.  Selective Serotonin Reuptake Inhibitors Aggravate Depression-Associated Dry Eye Via Activating the NF-κB Pathway  Invest Ophthalmol Vis Sci  2019  60(1):407-419  PubMed ID: 30695093   DOI: 10.1167/iovs.18-25572
12418  Žiniauskaitė A, Ragauskas S, Ghosh AK, Thapa R, Roessler AE, Koulen P, Kalesnykas G, Hakkarainen JJ, Kaja S.  Manganese(III) tetrakis(1-methyl-4-pyridyl) porphyrin, a superoxide dismutase mimetic, reduces disease severity in in vitro and in vivo models for dry-eye disease  Ocul Surf  2019  17(2):257-264  PubMed ID: 30807830   DOI: 10.1016/j.jtos.2019.02.006
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16670  Klinngam W, Janga SR, Lee C, Ju Y, Yarber F, Shah M, Guo H, Wang D, MacKay JA, Edman MC, Hamm-Alvarez SF.  Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sjögren's Syndrome  Sci Rep  2019  9(1):9559  PubMed ID: 31267034   DOI: 10.1038/s41598-019-45966-7
10627  Beißner N, Zorn-Kruppa M, Reichl S.  Parameter study of shipping conditions for the ready-to-use application of a 3D human hemicornea construct in drug absorption studies.  Int J Pharm  2018  536:377-387  PubMed ID: 29191484   DOI: 10.1016/j.ijpharm.2017.11.057
10824  Juretić M, Cetina-Čižmek B, Filipović-Grčić J, Hafner A, Lovrić J, Pepić I.  Biopharmaceutical evaluation of surface active ophthalmic excipients using in vitro and ex vivo corneal models.  Eur J Pharm Sci  2018  120:133-141  PubMed ID: 29702232   DOI: 10.1016/j.ejps.2018.04.032
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11142  Marek V, Melik-Parsadaniantz S, Villette T, Montoya F, Baudouin C, Brignole-Baudouin F, Denoyer A.  Blue light phototoxicity toward human corneal and conjunctival epithelial cells in basal and hyperosmolar conditions.  Free Radic. Biol. Med.  2018  126:27-40  PubMed ID: 30040995   DOI: 10.1016/j.freeradbiomed.2018.07.012
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6352  Hou A, Tong L.  Expression, Regulation, and Effects of Interleukin-17f in the Human Ocular Surface.  Ocul Immunol Inflamm  2018  26(7):1069-1077  PubMed ID: 28537453   DOI: 10.1080/09273948.2017.1316411
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15099  Zorn-Kruppa M, Houdek P, Wladykowski E, Engelke M, Bartok M, Mewes KR, Moll I, Brandner JM.  Determining the Depth of Injury in Bioengineered Tissue Models of Cornea and Conjunctiva for the Prediction of All Three Ocular GHS Categories  PLoS One  2014  9(12):e114181  PubMed ID: 25494045   DOI: 10.1371/journal.pone.0114181
15833  Ko JA, Mizuno Y, Ohki C, Chikama T, Sonoda KH, Kiuchi Y.  Neuropeptides released from trigeminal neurons promote the stratification of human corneal epithelial cells  Invest Ophthalmol Vis Sci  2014  55(1):125-33  PubMed ID: 24327615   DOI: 10.1167/iovs.13-12642
15995  Friedrich Erben, Dirk Michalik, Holger Feist, Dennis Kleeblatt, Martin Hein, Abdul Matin, Jamshed Iqbal, Peter Langer  Synthesis and antiproliferative activity of (Z)-1-glycosyl-3-(5-oxo-2-thioxoimidazolidin-4-ylidene)indolin-2-ones and (Z)-3-(2-glycosylsulfanyl-4-oxo-4,5-dihydro-thiazol-5-ylidene)indolin-2-ones  RSC Advances  2014  4:10879    DOI: 10.1039/c3ra44362k
16002  Wright B, De Bank PA, Luetchford KA, Acosta FR, Connon CJ.  Oxidized alginate hydrogels as niche environments for corneal epithelial cells  J Biomed Mater Res A  2014  102(10):3393-400  PubMed ID: 24142706   DOI: 10.1002/jbm.a.35011
6364  Wang N, Zimmerman K, Raab RW, McKown RL, Hutnik CM, Talla V, Tyler MF 4th, Lee JK, Laurie GW.  Lacritin rescues stressed epithelia via rapid forkhead box O3 (FOXO3)-associated autophagy that restores metabolism.  J Biol Chem.  2013.  288(25):18146-61  PubMed ID: 23640897   DOI: 10.1074/jbc.M112.436584
6323  Xu M, Sivak JG, McCanna DJ.  Comparison of the effects of ophthalmic solutions on human corneal epithelial cells using fluorescent dyes.  J Ocul Pharmacol Ther  2013  29(9):794-802  PubMed ID: 23905770   DOI: 10.1089/jop.2013.0002
6324  Yamaguchi H, Kojima H, Takezawa T.  Vitrigel-eye irritancy test method using HCE-T cells.  Toxicol Sci  2013  135(2):347-55  PubMed ID: 23872712   DOI: 10.1093/toxsci/kft159
6325  Rahimi M, Youn HY, McCanna DJ, Sivak JG, Mikkelsen SR.  Application of cyclic biamperometry to viability and cytotoxicity assessment in human corneal epithelial cells.  Anal Bioanal Chem  2013  405(14):4975-9  PubMed ID: 23443523   DOI: 10.1007/s00216-013-6843-z
6327  Tong L, Png E, Aihua H, Yong SS, Yeo HL, Riau A, Mendoz E, Chaurasia SS, Lim CT, Yiu TW, Iismaa SE.  Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion.  Biochim Biophys Acta.  2013  1833(6):1304-15  PubMed ID: 23466867   DOI: 10.1016/j.bbamcr.2013.02.030
6328  Hiroyoshi Kasai et al  Comparison of efficacy and safety evaluation of latanoprost formulations with and without benzalkonium chloride  Pharmacology & Pharmacy   2013  4:377-384    DOI: 10.4236/pp.2013.44054
6361  Verstraelen J, Reichl S.  Expression analysis of MDR1, BCRP and MRP3 transporter proteins in different in vitro and ex vivo cornea models for drug absorption studies.  Int J Pharm  2013  441(1-2):765-75  PubMed ID: 23069916   DOI: 10.1016/j.ijpharm.2012.10.007
6362  Borrelli M, Reichl S, Feng Y, Schargus M, Schrader S, Geerling G.  In vitro characterization and ex vivo surgical evaluation of human hair keratin films in ocular surface reconstruction after sterilization processing.  J Mater Sci Mater Med  2013  24(1):221-30  PubMed ID: 23015265   DOI: 10.1007/s10856-012-4774-4
6363  Hogerheyde TA, Stephenson SA, Harkin DG, Bray LJ, Madden PW, Woolf MI, Richardson NA.  Evaluation of Eph receptor and ephrin expression within the human cornea and limbus.  Exp Eye Res  2013  107:110-20  PubMed ID: 23247085   DOI: 10.1016/j.exer.2012.11.016
6365  Raju R, Jian B, Hooks JJ, Nagineni CN.  Transforming growth factor-β regulates the expression of anosmin (KAL-1) in human retinal pigment epithelial cells.  Cytokine  2013  61(3):724-7  PubMed ID: 23357298   DOI: 10.1016/j.cyto.2012.12.019
6333  George KA, Shadforth AM, Chirila TV, Laurent MJ, Stephenson SA, Edwards GA, Madden PW, Hutmacher DW, Harkin DG.  Effect of the sterilization method on the properties of Bombyx mori silk fibroin films.  Mater Sci Eng C Mater Biol Appl  2013  33(2):668-74  PubMed ID: 25427472   DOI: 10.1016/j.msec.2012.10.016
6366  Anitua E, Muruzabal F, Alcalde I, Merayo-Lloves J, Orive G.  Plasma rich in growth factors (PRGF-Endoret) stimulates corneal wound healing and reduces haze formation after PRK surgery.  Exp Eye Res  2013  115:153-61  PubMed ID: 23872360   DOI: 10.1016/j.exer.2013.07.007
6367  Paterson SM, Shadforth AM, Shaw JA, Brown DH, Chirila TV, Baker MV.  Improving the cellular invasion into PHEMA sponges by incorporation of the RGD peptide ligand: the use of copolymerization as a means to functionalize PHEMA sponges.  Mater Sci Eng C Mater Biol Appl  2013  33(8):4917-22  PubMed ID: 24094205   DOI: 10.1016/j.msec.2013.08.011
6368  Engelke M, Zorn-Kruppa M, Gabel D, Reisinger K, Rusche B, Mewes KR.  A human hemi-cornea model for eye irritation testing: quality control of production, reliability and predictive capacity.  Toxicol In Vitro  2013  27(1):458-68  PubMed ID: 22902307   DOI: 10.1016/j.tiv.2012.07.011
14321  Dutot M, Vincent J, Martin-Brisac N, Fabre I, Grasmick C, Rat P.  Ocular cytotoxicity evaluation of medical devices such as contact lens solutions and benefits of a rinse step in cleaning procedure  ALTEX  2013  30(1):41-9.  PubMed ID: 23338805   DOI: 10.14573/altex.2013.1.041
15778  Fukuda K, Ishida W, Tanaka H, Harada Y, Matsuda A, Ebihara N, Fukushima A.  Alarmins from corneal epithelial cells upregulate CCL11 and VCAM-1 in corneal fibroblasts  Invest Ophthalmol Vis Sci  2013  54(8):5817-23  PubMed ID: 23920370   DOI: 10.1167/iovs.13-11969
15787  Guo H, Du G, Wang L, Wang D, Hu L, Huang Y.  Integrin alpha v beta 6 contributes to maintaining corneal epithelial barrier function  Cell Biol Int  2013  37(6):593-9  PubMed ID: 23412966   DOI: 10.1002/cbin.10076
15934  Hafiz Muhammad Shoaib 1 , Ambreen Gul Muazzam, Asif Mir, Suk-Yul Jung, Abdul Matin  Evaluation of inhibitory potential of some selective methanolic plants extracts on biological characteristics of Acanthamoeba castellanii using human corneal epithelial cells in vitro  Parasitol Res  2013  112(3):1179-88  PubMed ID: 23306385   DOI: 10.1007/s00436-012-3249-3
16088  Iqbal J, Saeed A, Raza R, Matin A, Hameed A, Furtmann N, Lecka J, Sévigny J, Bajorath J.  Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors  Eur J Med Chem  2013  70:685-91  PubMed ID: 24215819   DOI: 10.1016/j.ejmech.2013.10.053
6315  Liang H, Baudouin C, Daull P, Garrigue JS, Brignole-Baudouin F.  Ocular safety of cationic emulsion of cyclosporine in an in vitro corneal wound-healing model and an acute in vivo rabbit model.  Mol Vis  2012  18:2195-204  PubMed ID: 22919267  
6369  Hattori M, Shimizu K, Katsumura K, Oku H, Sano Y, Matsumoto K, Yamaguchi Y, Ikeda T.  Effects of all-trans retinoic acid nanoparticles on corneal epithelial wound healing.  Graefes Arch Clin Exp Ophthalmol  2012  250(4):557-63  PubMed ID: 22048243   DOI: 10.1007/s00417-011-1849-8
6370  Kinoshita S, Kawasaki S, Kitazawa K, Shinomiya K.  Establishment of a human conjunctival epithelial cell line lacking the functional TACSTD2 gene (an American Ophthalmological Society thesis).  Trans Am Ophthalmol Soc  2012  110:166-77  PubMed ID: 23818740  
6371  Hahne M, Zorn-Kruppa M, Guzman G, Brandner JM, Haltner-Ukomado E, Wätzig H, Reichl S.  Prevalidation of a human cornea construct as an alternative to animal corneas for in vitro drug absorption studies.  J Pharm Sci  2012  101(8):2976-88  PubMed ID: 22581751   DOI: 10.1002/jps.23190
6372  Stefan M.Paterson et al  The synthesis and degradation of collagenase-degradable poly(2-hydroxyethyl methacrylate)-based hydrogels and sponges for potential applications as scaffolds in tissue engineering  Materials Science and Engineering: C   2012  32:2536-2544    DOI: 10.1016/j.msec.2012.07.037
9093  Bernice Wright, Richard A Cave, Joseph P Cook, Vitaliy V Khutoryanskiy, Shengli Mi, Bo Chen, Martin Leyland, Che J Connon  Enhanced Viability of Corneal Epithelial Cells for Efficient Transport/Storage Using a Structurally Modified Calcium Alginate Hydrogel  Regen Med2  2012  7 (3), 295-307  PubMed ID: 22594324   DOI: 10.2217/rme.12.7
15761  Zhou T, Zong R, Zhang Z, Zhu C, Pan F, Xiao X, Liu Z, He H, Ma JX, Liu Z, Zhou Y.  SERPINA3K protects against oxidative stress via modulating ROS generation/degradation and KEAP1-NRF2 pathway in the corneal epithelium  Invest Ophthalmol Vis Sci  2012  53(8):5033-43  PubMed ID: 22736614   DOI: 10.1167/iovs.12-9729
16034  Shinya Hattori, Dohiko Terada, Andreana Bibin Bintang, Takako Honda, Chiaki Yoshikawa, Hidetoshi Teramoto, Tsunenori Kameda, Tamada Yasushi, Hisatoshi Kobayashi  Influence of sterilisations on silk protein-based materials  Bioinspired, Biomimetic and Nanobiomaterials  2012  1:195-199    DOI: 10.1680/bbn.11.00006
7623  Sharma S, Mohanty S, Gupta D, Jassal M, Agrawal AK, Tandon R.  Cellular response of limbal epithelial cells on electrospun poly-ε-caprolactone nanofibrous scaffolds for ocular surface bioengineering: a preliminary in vitro study.  Mol. Vis.  2011  17:2898-910  PubMed ID: 22128237  
7815  Kato M, Hagiwara Y, Oda T, Imamura-Takai M, Aono H, Nakamura M.  Beneficial pharmacological effects of selective glucocorticoid receptor agonist in external eye diseases.  J Ocul Pharmacol Ther  2011  27:353-60  PubMed ID: 21574866   DOI: 10.1089/jop.2010.0177
7894  Png E, Lan W, Lazaroo M, Chen S, Zhou L, Tong L.  A new method of high-speed cellular protein separation and insight into subcellular compartmentalization of proteins.  Anal Bioanal Chem  2011  400:767-75  PubMed ID: 21380751   DOI: 10.1007/s00216-011-4810-0
7974  Youn HY, McCanna DJ, Sivak JG, Jones LW.  In vitro ultraviolet-induced damage in human corneal, lens, and retinal pigment epithelial cells.  Mol. Vis.  2011  17:237-46  PubMed ID: 21270970  
8152  Png E, Samivelu GK, Yeo SH, Chew J, Chaurasia SS, Tong L.  Hyperosmolarity-mediated mitochondrial dysfunction requires Transglutaminase-2 in human corneal epithelial cells.  J. Cell. Physiol.  2011  226:693-9  PubMed ID: 20717931   DOI: 10.1002/jcp.22389
6311  Takezawa T, Nishikawa K, Wang PC.  Development of a human corneal epithelium model utilizing a collagen vitrigel membrane and the changes of its barrier function induced by exposing eye irritant chemicals.  Toxicol In Vitro  2011  25(6):1237-41  PubMed ID: 21641988   DOI: 10.1016/j.tiv.2011.05.021
12746  Kimura K, Teranishi S, Kawamoto K, Nishida T.  Protective effect of dexamethasone against hypoxia-induced disruption of barrier function in human corneal epithelial cells  Exp Eye Res  2011  92(5):388-93  PubMed ID: 21354133   DOI: 10.1016/j.exer.2011.02.013
15712  Liu X, Lin Z, Zhou T, Zong R, He H, Liu Z, Ma JX, Liu Z, Zhou Y.  Anti-angiogenic and anti-inflammatory effects of SERPINA3K on corneal injury  PLoS One  2011  6(1):e16712  PubMed ID: 21304961   DOI: 10.1371/journal.pone.0016712
16306  Kimura K, Teranishi S, Orita T, Zhou H, Nishida T.  Role of β-Pix in corneal epithelial cell migration on fibronectin  Invest Ophthalmol Vis Sci  2011  52(6):3181-6  PubMed ID: 21228382   DOI: 10.1167/iovs.10-5684
8041  Shah A, Farooq AV, Tiwari V, Kim MJ, Shukla D.  HSV-1 infection of human corneal epithelial cells: receptor-mediated entry and trends of re-infection.  Mol. Vis.  2010  16:2476-86  PubMed ID: 21139972  
6374  Yamada T, Ueda T, Ugawa S, Ishida Y, Imayasu M, Koyama S, Shimada S.  Functional expression of transient receptor potential vanilloid 3 (TRPV3) in corneal epithelial cells: involvement in thermosensation and wound healing.  Exp Eye Res  2010  90(1):121-9  PubMed ID: 19793539   DOI: 10.1016/j.exer.2009.09.020
9081  Yuki Terasaka, Dai Miyazaki, Keiko Yakura, Tomoko Haruki, Yoshitsugu Inoue  Induction of IL-6 in Transcriptional Networks in Corneal Epithelial Cells After Herpes Simplex Virus Type 1 Infection  Invest Ophthalmol Vis Sci  2010  51 (5), 2441-9  PubMed ID: 20019363   DOI: 10.1167/iovs.09-4624
12758  Kimura K, Teranishi S, Kawamoto K, Nishida T.  Protection of human corneal epithelial cells from hypoxia-induced disruption of barrier function by hepatocyte growth factor  Exp Eye Res  2010  90(2):337-43  PubMed ID: 19944686   DOI: 10.1016/j.exer.2009.11.012
15696  Kimura K, Kawano S, Mori T, Inoue J, Hadachi H, Saito T, Nishida T.  Quantitative analysis of the effects of extracellular matrix proteins on membrane dynamics associated with corneal epithelial cell motility  Invest Ophthalmol Vis Sci   2010  51(9):4492-9  PubMed ID: 20357207   DOI: 10.1167/iovs.09-4380
16663  Imayasu M, Hori Y, Cavanagh HD.  Effects of multipurpose contact lens care solutions and their ingredients on membrane-associated mucins of human corneal epithelial cells  Eye Contact Lens  2010  36(6):361-6  PubMed ID: 21060261   DOI: 10.1097/ICL.0b013e3181faa43e
11686  Kimura K, Teranishi S, Nishida T.  Establishment of human corneal epithelial cells stably expressing human connexin43  Exp Eye Res  2010  90(1):4-9  PubMed ID: 19799899   DOI: 10.1016/j.exer.2009.09.002
8445  Dutot M, Liang H, Martin C, Rousseau D, Grynberg A, Warnet JM, Rat P.  Per os administered refined olive oil and marine PUFA-rich oils reach the cornea: possible role on oxidative stress through caveolin-1 modulation.  Nutr Metab (Lond)  2009  6:48  PubMed ID: 19930652   DOI: 10.1186/1743-7075-6-48
8502  Pauloin T, Dutot M, Liang H, Chavinier E, Warnet JM, Rat P.  Corneal protection with high-molecular-weight hyaluronan against in vitro and in vivo sodium lauryl sulfate-induced toxic effects.  Cornea  2009  28:1032-41  PubMed ID: 19724206   DOI: 10.1097/ICO.0b013e3181a0a3f8
8624  Pauloin T, Dutot M, Joly F, Warnet JM, Rat P.  High molecular weight hyaluronan decreases UVB-induced apoptosis and inflammation in human epithelial corneal cells.  Mol. Vis.  2009  15:577-83  PubMed ID: 19325714  
8697  Liu L, Tiffany J, Dang Z, Dart JK, Watson SL, Daniels JT, Geerling G.  Nourish and nurture: development of a nutrient ocular lubricant.  Invest. Ophthalmol. Vis. Sci.  2009  50:2932-9  PubMed ID: 19074805   DOI: 10.1167/iovs.08-1991
6376  Karla PK, Quinn TL, Herndon BL, Thomas P, Pal D, Mitra A.  Expression of multidrug resistance associated protein 5 (MRP5) on cornea and its role in drug efflux.  J Ocul Pharmacol Ther  2009  25(2):121-32  PubMed ID: 19323627   DOI: 10.1089/jop.2008.0084
9077  Kozaburo Hayashi, Laura C Hooper, Barbara Detrick, John J Hooks  HSV Immune Complex (HSV-IgG: IC) and HSV-DNA Elicit the Production of Angiogenic Factor VEGF and MMP-9  Arch Virol  2009  154 (2), 219-26  PubMed ID: 19115032   DOI: 10.1007/s00705-008-0303-7
12767  Kimura K, Teranishi S, Nishida T.  Interleukin-1beta-induced disruption of barrier function in cultured human corneal epithelial cells  Invest Ophthalmol Vis Sci  2009  50(2):597-603  PubMed ID: 19171646   DOI: 10.1167/iovs.08-2606
16691  Ko JA, Yanai R, Nishida T.  Up-regulation of ZO-1 expression and barrier function in cultured human corneal epithelial cells by substance P  FEBS Lett  2009  583(12):2148-53  PubMed ID: 19446555   DOI: 10.1016/j.febslet.2009.05.010
16694  Teranishi S, Kimura K, Nishida T.  Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro  Invest Ophthalmol Vis Sci  2009  50(12):5646-52  PubMed ID: 19494198   DOI: 10.1167/iovs.08-2534
8755  Dutot M, Liang H, Pauloin T, Brignole-Baudouin F, Baudouin C, Warnet JM, Rat P.  Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.  Mol. Vis.  2008  14:889-97  PubMed ID: 18490962  
8777  Alison C. Dunn A Jessica A. Cobb A Ana N. Kantzios A Sung Jin Lee AMalisa Sarntinoranont A Roger Tran-Son-Tay A W. Gregory Sawyer  Friction Coefficient Measurement of Hydrogel Materialson Living Epithelial Cells  Tribology Letters  2008  30:13-19    DOI: 10.1007/s11249-008-9306-5
8783  Cobb JA, Dunn AC, Kwon J, Sarntinoranont M, Sawyer WG, Tran-Son-Tay R.  A novel method for low load friction testing on living cells.  Biotechnol. Lett.  2008  30:801-6  PubMed ID: 18071637   DOI: 10.1007/s10529-007-9623-z
6299  Pauloin T, Dutot M, Warnet JM, Rat P.  In vitro modulation of preservative toxicity: high molecular weight hyaluronan decreases apoptosis and oxidative stress induced by benzalkonium chloride.  Eur J Pharm Sci.   2008  34(4-5):263-73  PubMed ID: 18534829   DOI: 10.1016/j.ejps.2008.04.006
6377  Becker U, Ehrhardt C, Schneider M, Muys L, Gross D, Eschmann K, Schaefer UF, Lehr CM.  A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability.  Altern Lab Anim  2008  36(1):33-44  PubMed ID: 18333713   DOI: 10.1177/026119290803600106
6378  Secker GA, Shortt AJ, Sampson E, Schwarz QP, Schultz GS, Daniels JT.  TGFbeta stimulated re-epithelialisation is regulated by CTGF and Ras/MEK/ERK signalling.  Exp Cell Res  2008  314(1):131-42  PubMed ID: 17915216   DOI: 10.1016/j.yexcr.2007.09.001
6379  Nishikiori N, Sawada N, Ohguro H.  Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9.  Jpn J Ophthalmol  2008  52(3):195-203  PubMed ID: 18661270   DOI: 10.1007/s10384-008-0524-z
6380  Benko S, Tozser J, Miklossy G, Varga A, Kadas J, Csutak A, Berta A, Rajnavolgyi E.  Constitutive and UV-B modulated transcription of Nod-like receptors and their functional partners in human corneal epithelial cells.  Mol Vis  2008  14:1575-83  PubMed ID: 18769647  
12787  Kimura K, Teranishi S, Fukuda K, Kawamoto K, Nishida T.  Delayed disruption of barrier function in cultured human corneal epithelial cells induced by tumor necrosis factor-alpha in a manner dependent on NF-kappaB  Invest Ophthalmol Vis Sci  2008  49(2):565-71  PubMed ID: 18235000   DOI: 10.1167/iovs.07-0419
15688  Kimura K, Teranishi S, Yamauchi J, Nishida T.  Role of JNK-dependent serine phosphorylation of paxillin in migration of corneal epithelial cells during wound closure  Invest Ophthalmol Vis Sci  2008  49(1):125-32  PubMed ID: 18172084   DOI: 10.1167/iovs.07-0725
16693  Yanai R, Liu Y, Ko JA, Nishida T.  Effects of ambient oxygen concentration on the proliferation and viability of cultured human corneal epithelial cells  Exp Eye Res  2008  86(2):412-8  PubMed ID: 18187131   DOI: 10.1016/j.exer.2007.11.014
6292  Miles DH, Thakur A, Cole N, Willcox MD.  The induction and suppression of the apoptotic response of HSV-1 in human corneal epithelial cells.  Invest Ophthalmol Vis Sci  2007  48(2):789-96  PubMed ID: 17251479   DOI: 10.1167/iovs.06-0609
6381  Ho JH, Chuang CH, Ho CY, Shih YR, Lee OK, Su Y.  Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells.  Invest Ophthalmol Vis Sci  2007  48(1):27-33  PubMed ID: 17197512   DOI: 10.1167/iovs.06-0826
15639  Kimura K, Hattori A, Usui Y, Kitazawa K, Naganuma M, Kawamoto K, Teranishi S, Nomizu M, Nishida T.  Stimulation of corneal epithelial migration by a synthetic peptide (PHSRN) corresponding to the second cell-binding site of fibronectin  Invest Ophthalmol Vis Sci  2007  48(3):1110-8  PubMed ID: 17325153   DOI: 10.1167/iovs.06-0704
8874  Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Kasper K, Geerling G.  Corneal epitheliotrophic capacity of three different blood-derived preparations.  Invest. Ophthalmol. Vis. Sci.  2006  47:2438-44  PubMed ID: 16723454   DOI: 10.1167/iovs.05-0876
9066  Liu L, Hartwig D, Harloff S, Herminghaus P, Wedel T, Geerling G.  An optimised protocol for the production of autologous serum eyedrops.  Graefes Arch. Clin. Exp. Ophthalmol.  2005  243:706-14  PubMed ID: 15756576   DOI: 10.1007/s00417-004-1106-5
9075  Joo JH, Alpatov R, Munguba GC, Jackson MR, Hunt ME, Sugrue SP.  Reduction of Pnn by RNAi induces loss of cell-cell adhesion between human corneal epithelial cells.  Mol. Vis.  2005  11:133-42  PubMed ID: 15735603  
6382  Gabison EE1, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA, De Wever B, Calvo F, Mauviel A, Menashi S.  Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction.  Am J Pathol  2005  166(1):209-19  PubMed ID: 15632013   DOI: 10.1016/S0002-9440(10)62245-6
16935  Saika S, Ikeda K, Yamanaka O, Miyamoto T, Ohnishi Y, Sato M, Muragaki Y, Ooshima A, Nakajima Y, Kao WW, Flanders KC, Roberts AB.  Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali  Am J Pathol  2005  166(5):1405-18  PubMed ID: 15855641   DOI: 10.1016/S0002-9440(10)62358-9
9344  Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP.  Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells.  Invest. Ophthalmol. Vis. Sci.  2003  44:4715-23  PubMed ID: 14578391   DOI: 10.1167/iovs.03-0240
6274  Miles D, Athmanathan S, Thakur A, Willcox M.  A novel apoptotic interaction between HSV-1 and human corneal epithelial cells.  Curr Eye Res  2003  26(3-4):165-74  PubMed ID: 12815544   DOI: 10.1076/ceyr.26.3.165.14899
6383  Papa V, Leonardi A, Getuli C, Pacelli V, Russo P, Milazzo G.  Effect of ofloxacin and netilmicin on human corneal and conjunctival cells in vitro.  J Ocul Pharmacol Ther  2003  19(6):535-45  PubMed ID: 14733711   DOI: 10.1089/108076803322660459



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