| 利用者成果(英) |
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21415
Fukuoka S, Koga Y, Yamauchi M, Koganemaru S, Yasunaga M, Shitara K, Doi T, Yoshino T, Kuronita T, Elenbaas B, Wahra P, Zhang H, Crowley L, Jenkins MH, Clark A, Kojima T.
p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab.
Sci Rep
2023
13(1):16017
PubMed ID: 37749105
DOI: 10.1038/s41598-023-40612-9
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21448
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H.
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J Am Chem Soc
2023
PubMed ID: 37874670
DOI: 10.1021/jacs.3c07145
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20609
Shen Y, Eng JS, Fajardo F, Liang L, Li C, Collins P, Tedesco D, Nolan-Stevaux O.
Cancer cell-intrinsic resistance to BiTE therapy is mediated by loss of CD58 costimulation and modulation of the extrinsic apoptotic pathway.
J Immunother Cancer
2022
10(3)
PubMed ID: 35296559
DOI: 10.1136/jitc-2021-004348
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20664
Han Y, Dong Q, Liu T, Chen X, Yu C, Zhang Y.
The novel mechanism of Med12-mediated drug resistance in a TGFBR2-independent manner.
Biochem Biophys Res Commun
2022
610:1-7
PubMed ID: 35461070
DOI: 10.1016/j.bbrc.2022.04.029
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12041
Hirano T, Shinsato Y, Tanabe K, Higa N, Kamil M, Kawahara K, Yamamoto M, Minami K, Shimokawa M, Arigami T, Yanagita S, Matushita D, Uenosono Y, Ishigami S, Kijima Y, Maemura K, Kitazono I, Tanimoto A, Furukawa T, Natsugoe S.
FARP1 boosts CDC42 activity from integrin αvβ5 signaling and correlates with poor prognosis of advanced gastric cancer.
Oncogenesis
2020
PubMed ID: 32029704
DOI: 10.1038/s41389-020-0190-7
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12127
An L, Nie P, Chen M, Tang Y, Zhang H, Guan J, Cao Z, Hou C, Wang W, Zhao Y, Xu H, Jiao S, Zhou Z.
MST4 kinase suppresses gastric tumorigenesis by limiting YAP activation via a non-canonical pathway.
J. Exp. Med.
2020
PubMed ID: 32271880
DOI: 10.1084/jem.20191817
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13385
Neggers JE, Paolella BR, Asfaw A, Rothberg MV, Skipper TA, Yang A, Kalekar RL, Krill-Burger JM, Dharia NV, Kugener G, Kalfon J, Yuan C, Dumont N, Gonzalez A, Abdusamad M, Li YY, Spurr LF, Wu WW, Durbin AD, Wolpin BM, Piccioni F, Root DE, Boehm JS, Cherniack AD, Tsherniak A, Hong AL, Hahn WC, Stegmaier K, Golub TR, Vazquez F, Aguirre AJ.
Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.
Cell Rep
2020
PubMed ID: 33326793
DOI: 10.1016/j.celrep.2020.108493
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14877
Liu T, Han Y, Yu C, Ji Y, Wang C, Chen X, Wang X, Shen J, Zhang Y, Lang JY.
MYC predetermines the sensitivity of gastrointestinal cancer to antifolate drugs through regulating TYMS transcription
EBioMedicine
2019
48:289-300
PubMed ID: 31648989
DOI: 10.1016/j.ebiom.2019.10.003
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10662
Miyamoto S, Nagamura Y, Nakabo A, Okabe A, Yanagihara K, Fukami K, Sakai R, Yamaguchi H.
Aberrant alternative splicing of RHOA is associated with loss of its expression and activity in diffuse-type gastric carcinoma cells.
Biochem. Biophys. Res. Commun.
2018
495:1942-1947
PubMed ID: 29247652
DOI: 10.1016/j.bbrc.2017.12.067
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9978
Kneissl J, Hartmann A, Pfarr N, Erlmeier F, Lorber T, Keller S, Zwingenberger G, Weichert W, Luber B.
Influence of the HER receptor ligand system on sensitivity to cetuximab and trastuzumab in gastric cancer cell lines.
J. Cancer Res. Clin. Oncol.
2017
143:573-600
PubMed ID: 27933395
DOI: 10.1007/s00432-016-2308-z
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14615
Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K.
Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer
Oncotarget
2017
8(64):107666-107677
PubMed ID: 29296196
DOI: 10.18632/oncotarget.22587
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5812
Hirashita Y et al
Reduced phosphorylation of ribosomal protein S6 is associated with sensitivity to MEK inhibition in gastric cancer cells.
Cancer Sci
2016
107(12):1919-1928
PubMed ID: 27699948
DOI: 10.1111/cas.13094
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15081
Awazu Y, Nakamura K, Mizutani A, Kakoi Y, Iwata H, Yamasaki S, Miyamoto N, Imamura S, Miki H, Hori A.
A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities
Mol Cancer Ther
2013
12(6):913-24
PubMed ID: 23548264
DOI: 10.1158/1535-7163.MCT-12-1011
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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