| 利用者成果(英) |
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17565
Arai Y, Yamanaka I, Okamoto T, Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, Matsumoto K, Okuzaki D, Watanabe Y.
Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists
iScience
2023
26(1):105742
PubMed ID: 36507221
DOI: 10.1016/j.isci.2022.105742
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17804
Toshiki Takahashi, Jun Shirai, Miyo Matsuda, Sae Nakanaga, Shin Matsushita, Kei Wakita, Mizuki Hayashishita, Rigel Suzuki, Aya Noguchi, Naoto Yokota, and Hiroyuki Kawahara
Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8- family GTPases
iScience
2023
DOI: 10.1016/ j.isci.2023.106652
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20922
Sasaki M, Tabata K, Kishimoto M, Itakura Y, Kobayashi H, Ariizumi T, Uemura K, Toba S, Kusakabe S, Maruyama Y, Iida S, Nakajima N, Suzuki T, Yoshida S, Nobori H, Sanaki T, Kato T, Shishido T, Hall WW, Orba Y, Sato A, Sawa H.
S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters.
Sci Transl Med
2023
15(679):eabq4064
PubMed ID: 36327352
DOI: 10.1126/scitranslmed.abq4064
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20993
Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H.
Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle.
Sci Rep
2023
13(1):323
PubMed ID: 36609635
DOI: 10.1038/s41598-022-27372-8
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21011
Hiyamizu S, Qiu H, Vuolo L, Stevenson NL, Shak C, Heesom KJ, Hamada Y, Tsurumi Y, Chiba S, Katoh Y, Stephens DJ, Nakayama K.
Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective IFT.
J Cell Sci
2023
PubMed ID: 36632779
DOI: 10.1242/jcs.260462
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21015
Shoji H, Kitao K, Miyazawa T, Nakagawa S.
Potentially reduced fusogenicity of syncytin-2 in New World monkeys.
FEBS Open Bio
2023
PubMed ID: 36647789
DOI: 10.1002/2211-5463.13555
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21065
Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A.
Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.
J Am Chem Soc
2023
145(1):135-142
PubMed ID: 36538570
DOI: 10.1021/jacs.2c08974
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21076
Sato M, Maishi N, Hida Y, Yanagawa-Matsuda A, Alam MT, Sakakibara-Konishi J, Nam JM, Onodera Y, Konno S, Hida K.
Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy.
Cancer Med
2023
PubMed ID: 36808261
DOI: 10.1002/cam4.5696
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21092
Yoshimoto S, Suzuki T, Otani N, Takahashi D, Toshima K, Dohmae N, Simizu S.
Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C-mannosylation.
FEBS Open Bio
2023
PubMed ID: 36680395
DOI: 10.1002/2211-5463.13561
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21101
Ota A, Morita H, Naganuma T, Miyamoto M, Jojima K, Nojiri K, Matsuda J, Kihara A.
Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides.
J Biol Chem
2023
104603
PubMed ID: 36907437
DOI: 10.1016/j.jbc.2023.104603
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17485
Tanikawa S, Ebisu Y, Sedlačík T, Semba S, Nonoyama T, Kurokawa T, Hirota A, Takahashi T, Yamaguchi K, Imajo M, Kato H, Nishimura T, Tanei ZI, Tsuda M, Nemoto T, Gong JP, Tanaka S.
Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction
Sci Rep
2023
13(1):2233
PubMed ID: 36788295
DOI: 10.1038/s41598-023-28870-z
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21104
Kawano T, Kashiwagi M, Kanuka M, Chen CK, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y.
ER proteostasis regulators cell-non-autonomously control sleep.
Cell Rep
2023
42(3):112267
PubMed ID: 36924492
DOI: 10.1016/j.celrep.2023.112267
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21158
Tao F, Kitamura K, Hanada S, Sugimoto K, Furihata T, Kojima N.
Rapid and Stable Formation Method of Human Astrocyte Spheroid in a High Viscous Methylcellulose Medium and Its Functional Advantages.
Bioengineering (Basel)
2023
10(3)
PubMed ID: 36978740
DOI: 10.3390/bioengineering10030349
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21159
Watanabe T, Narahari A, Bhardwaj E, Kuriyama K, Nishimura M, Izumi T, Fujimuro M, Ohno S.
Conserved cysteine residues in Kaposi's sarcoma herpesvirus ORF34 are necessary for viral production and viral pre-initiation complex formation.
bioRxiv
2023
PubMed ID: 36945456
DOI: 10.1101/2023.03.08.531831
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21179
Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A.
Lysine long-chain fatty acylation regulates the TEAD transcription factor.
Cell Rep
2023
112388
PubMed ID: 37060904
DOI: 10.1016/j.celrep.2023.112388
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21219
Jojima K, Kihara A.
Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS3.
Biochim Biophys Acta Mol Cell Biol Lipids
2023
1868(8):159335
PubMed ID: 37209771
DOI: 10.1016/j.bbalip.2023.159335
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21222
Takahashi T, Shirai J, Matsuda M, Nakanaga S, Matsushita S, Wakita K, Hayashishita M, Suzuki R, Noguchi A, Yokota N, Kawahara H.
Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases.
iScience
2023
26(5):106652
PubMed ID: 37182096
DOI: 10.1016/j.isci.2023.106652
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17502
Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S.
Local anesthetic lidocaine induces growth suppression of HeLa cells by decreasing and changing the cellular localization of the proliferation marker Ki-67
Genes Cells
2022
27(11):675-684
PubMed ID: 36074048
DOI: 10.1111/gtc.12983
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17510
Miku Akishino, Yuko Aoki, Hajime Baba, Makio Asakawa, Yoichiro Hama, Susumu Mitsutake
Red algae-derived isofloridoside activates the sweet taste receptor T1R2/T1R3
Food Bioscience
2022
50:102186
DOI: 10.1016/j.fbio.2022.102186
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17529
Tsukida K, Muramatsu SI, Osaka H, Yamagata T, Muramatsu K.
WDR45 variants cause ferrous iron loss due to impaired ferritinophagy associated with nuclear receptor coactivator 4 and WD repeat domain phosphoinositide interacting protein 4 reduction
Brain Commun
2022
4(6):fcac304
PubMed ID: 36751498
DOI: 10.1093/braincomms/fcac304
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17581
Kamiki H, Murakami S, Nishikaze T, Hiono T, Igarashi M, Furuse Y, Matsugo H, Ishida H, Katayama M, Sekine W, Muraki Y, Takahashi M, Takenaka-Uema A, Horimoto T.
Influenza A Virus Agnostic Receptor Tropism Revealed Using a Novel Biological System with Terminal Sialic Acid Knockout Cells
J Virol
2022
96(15):e0041622
PubMed ID: 35862707
DOI: 10.1128/jvi.00416-22
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17616
Yamashita F, Kaieda T, Shimomura T, Kawaguchi M, Lin CY, Johnson MD, Tanaka H, Kiwaki T, Fukushima T, Kataoka H.
Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1
FEBS J
2022
289(12):3422-3439
PubMed ID: 35020274
DOI: 10.1111/febs.16348
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17620
Saito S, Funayama K, Kato W, Okuda M, Kawamoto M, Matsubara T, Sato T, Sato A, Otsuguro S, Sasaki M, Orba Y, Sawa H, Maenaka K, Shindo K, Imoto M, Arai MA.
Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses
J Nat Prod
2022
85(11):2583-2591
PubMed ID: 36223390
DOI: 10.1021/acs.jnatprod.2c00550
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17651
Wei Z, Shimizu K, Sarii RS, Muthusinghe DS, Lokupathirage SMW, Nio-Kobayashi J, Yoshimatsu K.
Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome
Viruses
2022
14(10):2247
PubMed ID: 36298802
DOI: 10.3390/v14102247
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17675
Yamauchi K, Okamoto S, Ishida Y, Konno K, Hoshino K, Furuta T, Takahashi M, Koike M, Isa K, Watanabe M, Isa T, Hioki H.
Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis
Sci Rep
2022
12(1):14807
PubMed ID: 36097273
DOI: 10.1038/s41598-022-19085-9
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17714
Matsumura Y, To TK, Kunieda T, Kohno H, Kakutani T, Kubo T.
Mblk-1/E93, an ecdysone related-transcription factor, targets synaptic plasticity-related genes in the honey bee mushroom bodies
Sci Rep
2022
12(1):21367
PubMed ID: 36494426
DOI: 10.1038/s41598-022-23329-z
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17783
Ohshima T, Yamamoto H, Sakamaki Y, Saito C, Mizushima N.
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy
J Cell Biol
2022
221(10):e202203102
PubMed ID: 36066504
DOI: 10.1083/jcb.202203102
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17788
Takeuchi Y, Ushimaru K, Kaneda K, Maruyama C, Ito T, Yamanaka K, Ogasawara Y, Katano H, Kato Y, Dairi T, Hamano Y.
First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria
Commun Biol
2022
5(1):1132
PubMed ID: 36289442
DOI: 10.1038/s42003-022-04110-4
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20207
Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H.
Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles.
Arthritis Rheumatol
2022
PubMed ID: 34164946
DOI: 10.1002/art.41897
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20452
Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H.
ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma.
Oncol Rep
2022
47(2)
PubMed ID: 34841437
DOI: 10.3892/or.2021.8234
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20477
Arase N, Tsuji H, Takamatsu H, Jin H, Konaka H, Hamaguchi Y, Tonomura K, Kotobuki Y, Ueda-Hayakawa I, Matsuoka S, Hirano T, Yorifuji H, Murota H, Ohmura K, Nakashima R, Sato T, Kumanogoh A, Katayama I, Arase H, Fujimoto M.
Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.
J Autoimmun
2022
126:102774
PubMed ID: 34896887
DOI: 10.1016/j.jaut.2021.102774
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20517
Qiu H, Tsurumi Y, Katoh Y, Nakayama K.
Combinations of deletion and missense variations of the dynein-2 DYNC2LI1 subunit found in skeletal ciliopathies cause ciliary defects.
Sci Rep
2022
12(1):31
PubMed ID: 34997029
DOI: 10.1038/s41598-021-03950-0
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20522
Hiraiwa M, Fukasawa K, Iezaki T, Sabit H, Horie T, Tokumura K, Iwahashi S, Murata M, Kobayashi M, Suzuki A, Park G, Kaneda K, Todo T, Hirao A, Nakada M, Hinoi E.
SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability.
Commun Biol
2022
5(1):22
PubMed ID: 35017630
DOI: 10.1038/s42003-021-02950-0
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20524
Nomura T, Nagao K, Shirai R, Gotoh H, Umeda M, Ono K.
Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains.
Nat Commun
2022
13(1):96
PubMed ID: 35013223
DOI: 10.1038/s41467-021-27707-5
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16114
Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK.
Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts
Cell Biol Toxicol
2022
Mar 15
PubMed ID: 33723743
DOI: 10.1007/s10565-021-09592-2
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20588
Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H.
Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.
Sci Adv
2022
8(9):eabj9867
PubMed ID: 35245125
DOI: 10.1126/sciadv.abj9867
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20597
Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H.
Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window.
Biomed Opt Express
2022
13(2):694-708
PubMed ID: 35284173
DOI: 10.1364/BOE.446273
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20641
Miyajima Y, Noguchi S, Tanaka Y, Li JR, Nishimura H, Kishima M, Lim J, Furuhata E, Suzuki T, Kasukawa T, Suzuki H.
Prediction of transcription factors associated with DNA demethylation during human cellular development.
Chromosome Res
2022
30(1):109-121
PubMed ID: 35142952
DOI: 10.1007/s10577-022-09685-6
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20659
Chino H, Yamasaki A, Ode KL, Ueda HR, Noda NN, Mizushima N.
Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins.
EMBO Rep
2022
e54801
PubMed ID: 35417087
DOI: 10.15252/embr.202254801
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20702
Nashimoto Y, Matsushita F, Dijkstra JM, Nakamura Y, Akiyama H, Hamako J, Morita T, Araki S, Matsui T.
Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen.
Toxins (Basel)
2022
14(4)
PubMed ID: 35448845
DOI: 10.3390/toxins14040236
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20704
Kamo H, Kawahara R, Simizu S.
Tyrosinase suppresses vasculogenic mimicry in human melanoma cells.
Oncol Lett
2022
23(5):169
PubMed ID: 35496574
DOI: 10.3892/ol.2022.13289
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20713
Satoda Y, Noguchi T, Fujii T, Taniguchi A, Katoh Y, Nakayama K.
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to IFT turnaround involving ICK/CILK1.
Mol Biol Cell
2022
mbcE22030089
PubMed ID: 35609210
DOI: 10.1091/mbc.E22-03-0089
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16502
Kamada H, Yasuhira S, Shibazaki M, Amano H, Maesawa C.
DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells
J Invest Dermatol
2022
S0022-202X(22)00126-9
PubMed ID: 35189148
DOI: 10.1016/j.jid.2022.02.007
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20729
Ishida Y, Tasaki K, Katoh Y, Nakayama K.
Molecular basis underlying the ciliary defects caused by IFT52 variations found in skeletal ciliopathies.
Mol Biol Cell
2022
mbcE22050188
PubMed ID: 35704471
DOI: 10.1091/mbc.E22-05-0188
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16632
Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A.
Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells
Genes Dev
2022
36(1-2):84-102
PubMed ID: 34992147
DOI: 10.1101/gad.348782.121
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16658
Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M.
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells
Cell Chem Biol
2022
S2451-9456(22)00198-2
PubMed ID: 35728598
DOI: 10.1016/j.chembiol.2022.05.006
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16659
Matsuura-Suzuki E, Shimazu T, Takahashi M, Kotoshiba K, Suzuki T, Kashiwagi K, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Ito T, Shinkai Y, Iwasaki S.
METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance
Elife
2022
11:e72780
PubMed ID: 35674491
DOI: 10.7554/eLife.72780
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20750
Yamada T, Fukasawa K, Horie T, Kadota T, Lyu J, Tokumura K, Ochiai S, Iwahashi S, Suzuki A, Park G, Ueda R, Yamamoto M, Kitao T, Shirahase H, Ochi H, Sato S, Iezaki T, Hinoi E.
The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
Stem Cell Reports
2022
PubMed ID: 35777359
DOI: 10.1016/j.stemcr.2022.06.001
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16732
Zhu Z, Kitano T, Morimatsu M, Tanaka A, Morioka R, Lin X, Orino K, Yoshikawa Y.
BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents
Int J Mol Sci
2022
23(7):4060
PubMed ID: 35409418
DOI: 10.3390/ijms23074060
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16747
Fujii K, Morita S, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Yamaguchi K, Abe J, Yamazaki T, Imai T, Sugamura K, Yasuda J, Satoh K, Sato I, Saito-Koyama R, Fujishima F, Sasano H, Kato Y, Matsuura K, Asada Y, Tamai K.
Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry
Cancer Sci . 2022 Mar 28
2022
Mar 28
PubMed ID: 35343032
DOI: 10.1111/cas.15340
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16748
Song W, Isaji T, Nakano M, Liang C, Fukuda T, Gu J.
O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis
FASEB J
2022
36(2):e22149
PubMed ID: 34981577
DOI: 10.1096/fj.202101520R
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16749
Kitanishi T, Tashiro M, Kitanishi N, Mizuseki K.
Intersectional, anterograde transsynaptic targeting of neurons receiving monosynaptic inputs from two upstream regions
Commun Biol
2022
5(1):149
PubMed ID: 35190665
DOI: 10.1038/s42003-022-03096-3
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16750
Otsuka K, Sawai-Ogawa M, Kihara A.
Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention
FASEB J
2022
36(4):e22216
PubMed ID: 35238077
DOI: 10.1096/fj.202101733R
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16765
Takahashi S, Shibutani S, Iwata H.
Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation
Exp Cell Res
2022
418(1):113246
PubMed ID: 35697076
DOI: 10.1016/j.yexcr.2022.113246
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20788
Oishi T, Ito M, Koizumi S, Horikawa M, Yamamoto T, Yamagishi S, Yamasaki T, Sameshima T, Suzuki T, Sugimura H, Namba H, Kurozumi K.
Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases.
Mol Ther Methods Clin Dev
2022
26:253-265
PubMed ID: 35892087
DOI: 10.1016/j.omtm.2022.07.001
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20822
Deai M, Oya R, Saso N, Tanaka A, Uchida I, Miyake Y, Tachihara R, Otsugu M, Mine A, Sato K, Tomura H.
Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells.
Biochem Biophys Res Commun
2022
626:15-20
PubMed ID: 35964552
DOI: 10.1016/j.bbrc.2022.07.110
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17100
Izumi A, Yamamoto K, Kawaguchi M, Yamashita F, Fukushima T, Kiwaki T, Tanaka H, Yamashita Y, Kataoka H.
Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells
Cancer Sci
2022
113(6):2179-2193
PubMed ID: 35332604
DOI: 10.1111/cas.15346
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20836
Kashio M, Masubuchi S, Tominaga M.
Protein kinase C (PKC)-mediated phosphorylation of TRPM2 Thr738 counteracts the effect of cytosolic Ca2+ and elevates the temperature threshold.
J Physiol
2022
PubMed ID: 36042566
DOI: 10.1113/JP283350
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20845
Zhou Z, Katoh Y, Nakayama K.
CEP19-RABL2-IFT-B axis controls BBSome-mediated ciliary GPCR export.
Mol Biol Cell
2022
PubMed ID: 36074075
DOI: 10.1091/mbc.E22-05-0161
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20857
Nohara T, Ohno Y, Kihara A.
Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1.
J Dermatol Sci
2022
107(2):89-94
PubMed ID: 35970721
DOI: 10.1016/j.jdermsci.2022.07.008
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20869
Lyu X, Imai S, Yamano T, Hanayama R.
Preventing SARS-CoV-2 Infection Using Anti-spike Nanobody-IFN-β Conjugated Exosomes.
Pharm Res
2022
PubMed ID: 36163411
DOI: 10.1007/s11095-022-03400-0
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20873
Yamamura N, Mikkaichi T, Itokawa KI, Hoshi M, Damme K, Geigner S, Baumhauer C.
Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K.
Xenobiotica
2022
1-42
PubMed ID: 36170033
DOI: 10.1080/00498254.2022.2129517
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20880
Kanadome T, Hayashi K, Seto Y, Eiraku M, Nakajima K, Nagai T, Matsuda T.
Development of intensiometric indicators for visualizing N-cadherin interaction across cells.
Commun Biol
2022
5(1):1065
PubMed ID: 36207396
DOI: 10.1038/s42003-022-04023-2
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20892
Mang D, Mayu K, Toyama T, Yamagishi T, Sato R.
BmGr4 responds to sucrose and glucose and expresses in tachykinin-related peptide-secreting enteroendocrine cells.
Insect Biochem Mol Biol
2022
103858
PubMed ID: 36244651
DOI: 10.1016/j.ibmb.2022.103858
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Nakazato A, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Fujii K, Saijoh S, Morita S, Yamazaki T, Imai T, Sato I, Satoh K, Yamaguchi K, Sugamura K, Yasuda J, Matsuura K, Shojaku H, Asada Y, Tamai K.
RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer.
Sci Rep
2022
12(1):17751
PubMed ID: 36273237
DOI: 10.1038/s41598-022-22736-6
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20912
Kotani N, Nakano T, Kuwahara R.
Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis.
J Biol Chem
2022
298(11):102500
PubMed ID: 36152751
DOI: 10.1016/j.jbc.2022.102500
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20914
Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M.
Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes.
Nature
2022
PubMed ID: 36323784
DOI: 10.1038/s41586-022-05388-4
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20926
Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y.
Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress.
Redox Biol
2022
57:102514
PubMed ID: 36279630
DOI: 10.1016/j.redox.2022.102514
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17337
Sekine W, Takenaka-Uema A, Kamiki H, Ishida H, Matsugo H, Murakami S, Horimoto T.
Adaptation of the H7N2 Feline Influenza Virus to Human Respiratory Cell Culture
Viruses
2022
14(5):1091
PubMed ID: 35632832
DOI: 10.3390/v14051091
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20971
Tatsumi A, Hirakochi H, Inoue S, Tanaka Y, Furuno H, Ikeda M, Ishibashi S, Taguchi T, Yamamoto K, Onishi I, Sachs Z, Largaespada DA, Kitagawa M, Kurata M.
Identification of NRAS Downstream Genes with CRISPR Activation Screening.
Biology (Basel)
2022
11(11)
PubMed ID: 36358254
DOI: 10.3390/biology11111551
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20975
Moriyama H, Moriyama M, Ozawa T, Tsuruta D, Hayakawa T.
Differentiation of Human Adipose-Derived Mesenchymal Stromal/Stem Cells into Insulin-Producing Cells with A Single Tet-Off Lentiviral Vector System.
Cell J
2022
24(12):705-714
PubMed ID: 36527342
DOI: 10.22074/cellj.2022.557533.1063
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20998
Ozono T, Kimura Y, Suenaga T, Beck G, Jinno J, Aguirre C, Ikenaka K, Krainc D, Mochizuki H, Arase H.
Extracellular transportation of α-synuclein by HLA class II molecules.
Biochem Biophys Res Commun
2022
644:25-33
PubMed ID: 36621149
DOI: 10.1016/j.bbrc.2022.12.082
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21033
Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T.
Optogenetic induction of hibernation-like state with modified human Opsin4 in mice.
Cell Rep Methods
2022
2(11):100336
PubMed ID: 36452866
DOI: 10.1016/j.crmeth.2022.100336
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21037
Takahashi M, Kobayashi T, Mizuma H, Yamauchi K, Okamoto S, Okamoto K, Ishida Y, Koike M, Watanabe M, Isa T, Hioki H.
Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum.
Neurosci Res
2022
PubMed ID: 36574563
DOI: 10.1016/j.neures.2022.11.008
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17361
Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A.
Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease
J Med Chem
2022
65(20):13852-13865
PubMed ID: 36229406
DOI: 10.1021/acs.jmedchem.2c01081
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21141
Suenaga T, Mori Y, Suzutani T, Arase H.
Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B.
Biochem Biophys Res Commun
2022
607:67-72
PubMed ID: 35367830
DOI: 10.1016/j.bbrc.2022.03.060
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17694
Furuta T, Yamauchi K, Okamoto S, Takahashi M, Kakuta S, Ishida Y, Takenaka A, Yoshida A, Uchiyama Y, Koike M, Isa K, Isa T, Hioki H.
Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, Sca l eSF
iScience
2021
25(1):103601
PubMed ID: 35106459
DOI: 10.1016/j.isci.2021.103601
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12798
Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M.
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
Science
2021
371(6526):265-270
PubMed ID: 33446552
DOI: 10.1126/science.abb5916
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13320
Matsumoto N, Sekiya M, Fujimoto Y, Haga S, Sun-Wada GH, Wada Y, Nakanishi-Matsui M.
Functional complementation of V-ATPase a subunit isoforms in osteoclasts.
J Biochem
2021
169(4):459-466
PubMed ID: 33135054
DOI: 10.1093/jb/mvaa118
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13345
Daifu T, Mikami M, Hiramatsu H, Iwai A, Umeda K, Noura M, Kubota H, Masuda T, Furuichi K, Takasaki S, Noguchi Y, Morita K, Bando T, Hirata M, Kataoka TR, Nakahata T, Kuwahara Y, Iehara T, Hosoi H, Takita J, Sugiyama H, Adachi S, Kamikubo Y.
Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition.
Pediatr Blood Cancer
2021
PubMed ID: 33180377
DOI: 10.1002/pbc.28789
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13351
Matsumoto Y, Kishida K, Matsumoto M, Matsuoka S, Kohyama M, Suenaga T, Arase H.
A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice.
Biochem Biophys Res Commun
2021
PubMed ID: 33208230
DOI: 10.1016/j.bbrc.2020.11.019
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13463
Shota Someya et al
Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells
iScienc
2021
24
PubMed ID: 33615198
DOI: 10.1016/j.isci.2021.102090
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20008
Umaba R, Kitanishi T, Mizuseki K.
Monosynaptic connection from the subiculum to medial mammillary nucleus neurons projecting to the anterior thalamus and Gudden's ventral tegmental nucleus.
Neurosci Res
2021
PubMed ID: 33476683
DOI: 10.1016/j.neures.2021.01.006
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20053
Takafuji S, Mori T, Nishimura N, Yamamoto N, Uemura S, Nozu K, Terui K, Toki T, Ito E, Muramatsu H, Takahashi Y, Matsuo M, Yamamura T, Iijima K.
Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19.
Pediatr Hematol Oncol
2021
1-16
PubMed ID: 33622161
DOI: 10.1080/08880018.2021.1887984
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20060
Nishiike Y, Miyazoe D, Togawa R, Yokoyama K, Nakasone K, Miyata M, Kikuchi Y, Kamei Y, Todo T, Ishikawa-Fujiwara T, Ohno K, Usami T, Nagahama Y, Okubo K.
Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka.
Curr Biol
2021
PubMed ID: 33639108
DOI: 10.1016/j.cub.2021.01.089
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13513
Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M.
Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A
J Immunol
2021
206(4):737-750
PubMed ID: 33452125
DOI: 10.4049/jimmunol.2000817
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20067
Aizawa N, Fujimori Y, Nakanishi O, Hayashi T, Goi Y, Kobayashi JI, Fujita T.
Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β3-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity.
Eur J Pharmacol
2021
173995
PubMed ID: 33675781
DOI: 10.1016/j.ejphar.2021.173995
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20068
Nakamura R, Oyama T, Inokuchi M, Ishikawa S, Hirata M, Kawashima H, Ikeda H, Dobashi Y, Ooi A.
Neural EGFL like 2 expressed in myoepithelial cells and suppressed breast cancer cell migration.
Pathol Int
2021
PubMed ID: 33657249
DOI: 10.1111/pin.13087
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13640
Fujita K, Koide N, Somiya M, Kuroda S, Hinuma S.
A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells
Biochim Biophys Acta Mol Cell Res
2021
1868(1):118859
PubMed ID: 32956759
DOI: 10.1016/j.bbamcr.2020.118859
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20083
Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K.
Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues.
Sci Rep
2021
11(1):6163
PubMed ID: 33731797
DOI: 10.1038/s41598-021-85603-w
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20103
McKee HK, Kajiwara C, Yamaguchi T, Ishii Y, Shimizu N, Ohara A, Tateda K.
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-α via Toll-like receptors in macrophages.
J Med Microbiol
2021
70(4)
PubMed ID: 33830910
DOI: 10.1099/jmm.0.001342
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13898
Takuma Kitanishi, Ryoko Umaba, Kenji Mizuseki
Robust information routing by dorsal subiculum neurons
Sci Adv
2021
7(11):eabf1913
PubMed ID: 33692111
DOI: 10.1126/sciadv.abf1913
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13913
Rai D, Akagi T, Shimohata A, Ishii T, Gangi M, Maruyama T, Wada-Kiyama Y, Ogiwara I, Kaneda M.
Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6
J Neurochem
2021
158(4):837-848
PubMed ID: 33067823
DOI: 10.1111/jnc.15217
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20114
Ojiro I, Nishio H, Yamazaki-Ito T, Nakano S, Ito S, Toyohara Y, Hiramoto T, Terada Y, Ito K.
Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46.
Biosci Biotechnol Biochem
2021
PubMed ID: 33844825
DOI: 10.1093/bbb/zbab061
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20138
Nagumo Y, Kandori S, Tanuma K, Nitta S, Chihara I, Shiga M, Hoshi A, Negoro H, Kojima T, Mathis BJ, Funakoshi Y, Nishiyama H.
PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer.
Cancer Lett
2021
511:15-25
PubMed ID: 33945837
DOI: 10.1016/j.canlet.2021.04.014
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20147
Kariya Y, Oyama M, Suzuki T, Kariya Y.
αvβ3 Integrin induces partial EMT independent of TGF-β signaling.
Commun Biol
2021
4(1):490
PubMed ID: 33883697
DOI: 10.1038/s42003-021-02003-6
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14182
Somiya M, Kuroda S.
Real-Time Luminescence Assay for Cytoplasmic Cargo Delivery of Extracellular Vesicles
Anal Chem
2021
93(13):5612-5620
PubMed ID: 33759512
DOI: 10.1021/acs.analchem.1c00339
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20150
Takeshita M, Suzuki K, Nakazawa M, Kamata H, Ishii M, Oyamada Y, Oshima H, Takeuchi T.
Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease.
J Autoimmun
2021
121:102661
PubMed ID: 34034155
DOI: 10.1016/j.jaut.2021.102661
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20155
Sahoo PR, Kowada T, Mizukami S.
Long-Term Mg2+ Imaging in Live Cells with a Targetable Fluorescent Probe.
Methods Mol Biol
2021
2274:237-243
PubMed ID: 34050476
DOI: 10.1007/978-1-0716-1258-3_20
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20157
Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A.
Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease.
Nat Commun
2021
12(1):3101
PubMed ID: 34035300
DOI: 10.1038/s41467-021-23452-x
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20158
Osakabe K, Wada N, Murakami E, Miyashita N, Osakabe Y.
Genome editing in mammalian cells using the CRISPR type I-D nuclease.
Nucleic Acids Res
2021
PubMed ID: 34076237
DOI: 10.1093/nar/gkab348
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20165
Kobayashi JI, Hirasawa H, Fujimori Y, Nakanishi O, Kamada N, Ikeda T, Yamamoto A, Kanbe H.
Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects.
Bioorg Med Chem
2021
30:115903
PubMed ID: 33333445
DOI: 10.1016/j.bmc.2020.115903
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14478
Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y.
Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on β-Glucan-Specific Antibody Production in Healthy Human Volunteers
Int J Med Mushrooms
2021
23(2):13-28
PubMed ID: 33639078
DOI: 10.1615/IntJMedMushrooms.2020037471
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20199
Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S.
Extracellular mRNA transported to the nucleus exerts translation-independent function.
Nat Commun
2021
12(1):3655
PubMed ID: 34135341
DOI: 10.1038/s41467-021-23969-1
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20200
Kuwabara S, Tanimoto Y, Okutani M, Jie M, Haseda Y, Kinugasa-Katayama Y, Aoshi T.
Microfluidics sorting enables the isolation of an intact cellular pair complex of CD8+ T cells and antigen-presenting cells in a cognate antigen recognition-dependent manner.
PLoS One
2021
16(6):e0252666
PubMed ID: 34125844
DOI: 10.1371/journal.pone.0252666
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20216
Niinae T, Imami K, Sugiyama N, Ishihama Y.
Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs.
Mol Cell Proteomics
2021
100119
PubMed ID: 34186244
DOI: 10.1016/j.mcpro.2021.100119
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14782
Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A.
MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2
Sci Rep
2021
11(1):5376
PubMed ID: 33686154
DOI: 10.1038/s41598-021-84882-7
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14827
iu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H.
An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies
Cell
2021
184(13):3452-3466.e18
PubMed ID: 34139176
DOI: 10.1016/j.cell.2021.05.032
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20233
Koshizuka T, Kondo H, Kato H, Takahashi K.
Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases.
Microbiol Immunol
2021
PubMed ID: 34260096
DOI: 10.1111/1348-0421.12932
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20240
Kaku T, Sugiura K, Entani T, Osabe K, Nagai T.
Enhanced brightness of bacterial luciferase by bioluminescence resonance energy transfer.
Sci Rep
2021
11(1):14994
PubMed ID: 34294849
DOI: 10.1038/s41598-021-94551-4
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14939
Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda
Binding of Nanoparticles Harboring Recombinant Large Surface Protein of Hepatitis B Virus to Scavenger Receptor Class B Type 1
Viruses
2021
13:1334
PubMed ID: 34372540
DOI: 10.3390/v13071334
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20244
Yoshioka K, Obara K, Oikawa S, Uemura K, Yamaguchi A, Fujisawa K, Hanazawa H, Fujiwara M, Endoh T, Suzuki T, Regadera MD, Ito D, Ou G, Xu K, Tanaka Y.
Docosahexaenoic acid inhibits U46619- and prostaglandin F2α-induced pig coronary and basilar artery contractions by inhibiting prostanoid TP receptors.
Eur J Pharmacol
2021
174371
PubMed ID: 34329614
DOI: 10.1016/j.ejphar.2021.174371
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20272
Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R.
Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA.
Sci Rep
2021
11(1):13471
PubMed ID: 34188113
DOI: 10.1038/s41598-021-92860-2
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15168
Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T.
Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells
Nat Immunol
2021
22(8):947-957
PubMed ID: 34239121
DOI: 10.1038/s41590-021-00967-5
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20282
Nakanishi E, Uemura N, Akiyama H, Kinoshita M, Masanori S, Taruno Y, Yamakado H, Matsuzawa SI, Takeda S, Hirabayashi Y, Takahashi R.
Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes).
Mol Brain
2021
14(1):80
PubMed ID: 33971917
DOI: 10.1186/s13041-021-00790-x
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20283
Sakoguchi A, Saito F, Hirayasu K, Shida K, Matsuoka S, Itagaki S, Nakai W, Kohyama M, Suenaga T, Iwanaga S, Horii T, Arase H.
Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2.
Biochem Biophys Res Commun
2021
548:167-173
PubMed ID: 33647792
DOI: 10.1016/j.bbrc.2021.02.033
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20298
Nagano C, Takaoka Y, Kamei K, Hamada R, Ichikawa D, Tanaka K, Aoto Y, Ishiko S, Rossanti R, Sakakibara N, Okada E, Horinouchi T, Yamamura T, Tsuji Y, Noguchi Y, Ishimori S, Nagase H, Ninchoji T, Iijima K, Nozu K.
Genotype-Phenotype Correlation in WT1 Exon 8 to 9 Missense Variants.
Kidney Int Rep
2021
6(8):2114-2121
PubMed ID: 34386660
DOI: 10.1016/j.ekir.2021.05.009
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20322
Fujisawa S, Qiu H, Nozaki S, Chiba S, Katoh Y, Nakayama K.
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane.
Biol Open
2021
PubMed ID: 34447983
DOI: 10.1242/bio.058843
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15284
Yoshiko Iizuka, Kinuko Inomata, Risako Nohara, Akimitsu Miyawaki and Yoshifumi Watanabe
Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus
International Journal of Herbal Medicine
2021
9(3):54-60
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15524
Fukasawa K, Kadota T, Horie T, Tokumura K, Terada R, Kitaguchi Y, Park G, Ochiai S, Iwahashi S, Okayama Y, Hiraiwa M, Yamada T, Iezaki T, Kaneda K, Yamamoto M, Kitao T, Shirahase H, Hazawa M, Wong RW, Todo T, Hirao A, Hinoi E.
CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway
Oncogene
2021
40(15):2803-2815
PubMed ID: 33727660
DOI: 10.1038/s41388-021-01745-1
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20354
Noguchi T, Nakamura K, Satoda Y, Katoh Y, Nakayama K.
CCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32.
PLoS One
2021
16(10):e0258497
PubMed ID: 34624068
DOI: 10.1371/journal.pone.0258497
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20356
Yasumura M, Hagiwara A, Hida Y, Ohtsuka T.
Planar cell polarity protein Vangl2 and its interacting protein Ap2m1 regulate dendritic branching in cortical neurons.
Genes Cells
2021
PubMed ID: 34626136
DOI: 10.1111/gtc.12899
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20367
Kariya Y, Oyama M, Kariya Y, Hashimoto Y.
Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.
Biomolecules
2021
11(9)
PubMed ID: 34572536
DOI: 10.3390/biom11091323
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20403
Yaguchi A, Oshikawa M, Watanabe G, Hiramatsu H, Uchida N, Hara C, Kaneko N, Sawamoto K, Muraoka T, Ajioka I.
Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration.
Nat Commun
2021
12(1):6623
PubMed ID: 34799548
DOI: 10.1038/s41467-021-26896-3
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20440
Kanadome T, Hoshino N, Nagai T, Matsuda T, Yagi T.
Development of FRET-based indicators for visualizing homophilic trans interaction of a clustered protocadherin.
Sci Rep
2021
11(1):22237
PubMed ID: 34782670
DOI: 10.1038/s41598-021-01481-2
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15879
Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K.
5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2
iScience
2021
24(10):103120
PubMed ID: 34541466
DOI: 10.1016/j.isci.2021.103120
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15898
Yafei Liu, Noriko Arase, Jun-ichi Kishikawa, Mika Hirose, Songling Li, Asa Tada, Sumiko Matsuoka, Akemi Arakawa, Kanako Akamatsu, Chikako Ono, Hui Jin, Kazuki Kishida, Wataru Nakai, Masako Kohyama, Atsushi Nakagawa, Yoshiaki Yamagishi, Hironori Nakagami, Atsushi Kumanogoh, Yoshiharu Matsuura, Daron M. Standley, Takayuki Kato, Masato Okada, Manabu Fujimoto, Hisashi Arase
The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines
bioRxiv
2021
DOI: 10.1101/2021.08.22.457114
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20490
Ito F, Kato K, Yanatori I, Murohara T, Toyokuni S.
Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.
Redox Biol
2021
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Viruses
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J Extracell Vesicles
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Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy
Hepatology
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PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization
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Front Endocrinol (Lausanne)
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iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma
Cancer Immunol Res
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Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth
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Cytotechnology
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V-ATPase a3 Isoform Mutations Identified in Osteopetrosis Patients Abolish Its Expression and Disrupt Osteoclast Function
Exp Cell Res
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17β-Hydroxysteroid Dehydrogenase Type 12a Responsible for Testicular 11-ketotestosterone Synthesis in the Japanese Eel, Anguilla Japonica
J Steroid Biochem Mol Biol
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HTLV-1 Induces T Cell Malignancy and Inflammation by Viral Antisense Factor-Mediated Modulation of the Cytokine Signaling
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AirID, a novel proximity biotinylation enzyme, for analysis of protein-protein interactions.
Elife
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Neuroplastinβ-mediated upregulation of solute carrier family 22 member 18 antisense (SLC22A18AS) plays a crucial role in the epithelial-mesenchymal transition, leading to lung cancer cells' enhanced motility.
Biochem Biophys Rep
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Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H.
Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need.
Sci Rep
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Horinouchi T, Yamamura T, Minamikawa S, Nagano C, Sakakibara N, Nakanishi K, Shima Y, Morisada N, Ishiko S, Aoto Y, Nagase H, Takeda H, Rossanti R, Ishimori S, Kaito H, Matsuo M, Iijima K, Nozu K.
Pathogenic evaluation of synonymous COL4A5 variants in X-linked Alport syndrome using a minigene assay.
Mol Genet Genomic Med
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Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.
Redox Biol
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Yamashita J, Takeuchi A, Hosono K, Fleming T, Nagahama Y, Okubo K.
Male-predominant galanin mediates androgen-dependent aggressive chases in medaka.
Elife
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Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence.
Sci Rep
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Huetter J, Gritzan U, Gutcher I, Doecke WD, Luetke-Eversloh MV, Golfier S, Roider HG, Frisk AL, Hunter J, Pow A, Drake A, Levine Z, Levy O, Azulay M, Barbiro I, Cojocaru G, Vaknin I, Kreft B, Roese L.
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2).
Cancer Immunol Res
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Kakizawa S, Kishimoto Y, Yamamoto S, Onga K, Yasuda K, Miyamoto Y, Watanabe M, Sakai R, Mori N.
Functional maintenance of calcium store by ShcB adaptor protein in cerebellar Purkinje cells.
Sci Rep
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Ago Y, Otsuka H, Sasai H, Abdelkreem E, Nakama M, Aoyama Y, Matsumoto H, Fujiki R, Ohara O, Akiyama K, Fukui K, Watanabe Y, Nakajima Y, Ohnishi H, Ito T, Fukao T.
Japanese patients with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency: In vitro functional analysis of five novel HMGCS2 mutations.
Exp Ther Med
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Diffusible GRAPHIC to visualize morphology of cells after specific cell-cell contact.
Sci Rep
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Kitao T, Taguchi K, Seto S, Arasaki K, Ando H, Nagai H, Kubori T.
Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase.
Cell Rep
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Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y.
PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range.
J Virol
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Okamura M, Shizu R, Abe T, Kodama S, Hosaka T, Sasaki T, Yoshinari K.
PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice.
Cells
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Kato M, Onoyama I, Kawakami M, Yoshida S, Kawamura K, Kodama K, Hori E, Cui L, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K.
Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia.
PLoS One
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Yamazaki T, Takahashi C, Taniguchi Y, Narukawa M, Misaka T, Ano Y.
Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells.
Biochem Biophys Res Commun
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Osakabe K, Wada N, Miyaji T, Murakami E, Marui K, Ueta R, Hashimoto R, Abe-Hara C, Kong B, Yano K, Osakabe Y.
Genome editing in plants using CRISPR type I-D nuclease.
Commun Biol
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Shoji S, Hanada K, Takahashi M, Watanabe K, Yonemochi M, Tomabechi Y, Shirouzu M.
The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction
FEBS Lett
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Development of a Single Construct System for Site-Directed RNA Editing Using MS2-ADAR
Int J Mol Sci
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Harada M, Nghia VT, Nakao A, Tanigaki R, Fukuoka N, Nishida A, Kataoka T.
Eomesodermin promotes interaction of RelA and NFATc2 with the Ifng promoter and multiple conserved noncoding sequences across the Ifng locus in mouse lymphoma BW5147 cells
Immunol Lett
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Suzuki T, Morimoto N, Akaike A, Osakada F.
Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors
Front Neural Circuits
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Overexpression of neural miRNAs miR-9/9* and miR-124 suppresses differentiation to Müller glia and promotes differentiation to neurons in mouse retina in vivo
Genes Cells
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Cooperative activation of the human herpesvirus 6B U79/80 early gene promoter by immediate-early proteins IE1B and IE2B
Microbiol Immunol
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Species-Dependent Enhancement of Ovarian Cancer G Protein-Coupled Receptor 1 Activation by Ogerin
Zoolog Sci
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TGF-β-Induced TMEPAI Attenuates the Response of Triple-Negative Breast Cancer Cells to Doxorubicin and Paclitaxel
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N-terminal [Glu] 3 moiety of γ-glutamyl peptides contributes largely to the activation of human calcium-sensing receptor, a kokumi receptor
Biosci Biotechnol Biochem
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GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer
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Establishment of a Reverse Genetics System for Influenza D Virus
J Virol
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Overexpression of RUNX3 Represses RUNX1 to Drive Transformation of Myelodysplastic Syndrome
Cancer Res
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Lysosome-Associated Membrane Proteins Support the Furin-Mediated Processing of the Mumps Virus Fusion Protein
J Virol
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Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells
Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells
Int J Mol Sci
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An Antiviral Drug Screening Platform with a FRET Biosensor for Measurement of Arenavirus Z Assembly
Cell Struct Funct
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Synthesis of C12-Keto Saxitoxin Derivatives with Unusual Inhibitory Activity Against Voltage-Gated Sodium Channels
Chemistry
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Mol Med Rep
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Globo-series glycosphingolipids enhance Toll-like receptor 4-mediated inflammation and play a pathophysiological role in diabetic nephropathy.
Glycobiology
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Mol. Cell. Biochem.
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J. Biol. Chem.
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Elife
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Kataoka K, Miyoshi H, Sakata S, Dobashi A, Couronné L, Kogure Y, Sato Y, Nishida K, Gion Y, Shiraishi Y, Tanaka H, Chiba K, Watatani Y, Kakiuchi N, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Sanada M, Onozawa M, Teshima T, Yoshiki Y, Ishida T, Suzuki K, Shimada K, Tomita A, Kato M, Ota Y, Izutsu K, Demachi-Okamura A, Akatsuka Y, Miyano S, Yoshino T, Gaulard P, Hermine O, Takeuchi K, Ohshima K, Ogawa S.
Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.
Leukemia
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Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes.
Biochem. Biophys. Res. Commun.
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Int. Immunol.
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Type I interferon protects neurons from prions in in vivo models.
Brain
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Biochem. Biophys. Res. Commun.
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Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.
Sci Rep
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Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M.
Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.
Cancer Lett.
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TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2.
Int J Mol Sci
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Mol Cell
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Int. J. Oncol.
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The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells.
Exp. Cell Res.
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Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.
Neoplasia
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Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.
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Exp. Cell Res.
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PLoS Pathog.
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Evolutionary and Functional Diversity of the 5' Untranslated Region of Enterovirus D68: Increased Activity of the Internal Ribosome Entry Site of Viral Strains during the 2010s.
Viruses
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Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H.
Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.
Commun Biol
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Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population.
Genome Med
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Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.
Sci Rep
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Yamanashi T, Maki M, Kojima K, Shibukawa A, Tsukamoto T, Chowdhury S, Yamanaka A, Takagi S, Sudo Y.
Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination.
Sci Rep
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Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells.
RNA
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Kamiki H, Matsugo H, Ishida H, Kobayashi-Kitamura T, Sekine W, Takenaka-Uema A, Murakami S, Horimoto T.
Adaptation of H3N2 canine influenza virus to feline cell culture.
PLoS ONE
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High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.
Res. Vet. Sci.
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Protons Differentially Activate TDAG8 Homologs from Various Species.
Zoolog Sci
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Identification of sinensetin and nobiletin as major antitrypanosomal factors in a citrus cultivar.
Exp Parasitol
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Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma
Induction of Lipid Droplets in Non-Macrophage Cells as Well as Macrophages by Liposomes and Exosomes
Biochem Biophys Res Commun
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Uchibori R, Teruya T, Ido H, Ohmine K, Sehara Y, Urabe M, Mizukami H, Mineno J, Ozawa K.
Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor
Mol Ther Oncolytics
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Arisa Mitani, Takeshi Kobayashi, Yasuhito Hayashi, Natsuki Matsushita, Sachi Matsushita, Saori Nakao, Naoko Takahira, Atsushi Shiraishi, Yuichi Ohashi
Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line
PLoS One
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Nobuyoshi Tajima, Liu Xiaoyan, Makoto Taniguchi, Nobuo Kato
24S-hydroxycholesterol alters activity of large-conductance Ca 2+-dependent K + (slo1 BK) channel through intercalation into plasma membrane
Biochim Biophys Acta Mol Cell Biol Lipids
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1864(10):1525-1535
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Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN
Front Immunol
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Takahashi Y, Takahashi H, Stern PL, Kirita T, Tsuboi A.
Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae
Front Cell Neurosci
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Ichikawa T, Nakahata S, Fujii M, Iha H, Shimoda K, Morishita K.
The regulation of NDRG2 expression during ATLL development after HTLV-1 infection
Biochim Biophys Acta Mol Basis Dis
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Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro
Drug Metab Pharmacokinet
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Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M.
Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts
Oncol Res
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Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry
PLoS One
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Mechanism underlying the retarded nuclear translocation of androgen receptor splice variants
Sci China Life Sci
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Yoh T, Hatano E, Kasai Y, Fuji H, Nishi K, Toriguchi K, Sueoka H, Ohno M, Seo S, Iwaisako K, Taura K, Yamaguchi R, Kurokawa M, Fujimoto J, Kimura T, Uemoto S, Nishi E.
Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection
Clin Cancer Res
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Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer
Int J Mol Sci
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Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression
Mol Carcinog
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JCI Insight
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Sci Rep
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Zool. Sci.
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Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.
Development
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A novel fiber-free technique for brain activity imaging in multiple freely behaving mice
SPIE BiOS
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Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.
Nat Commun
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Arch. Biochem. Biophys.
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Eur. J. Pharmacol.
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Chem. Commun. (Camb.)
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Nat Commun
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UBL3 modification influences protein sorting to small extracellular vesicles.
Nat Commun
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BMC Vet. Res.
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MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.
Biochim Biophys Acta Gene Regul Mech
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Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1.
Sci Rep
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A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice.
Viruses
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Cell Chem Biol
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Retrovirology
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Nature
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Neoplasia
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Virology
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Arthritis Rheumatol
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Blood Adv
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FEBS Open Bio
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An in vitro splicing assay reveals the pathogenicity of a novel intronic variant in ATP6V0A4 for autosomal recessive distal renal tubular acidosis.
BMC Nephrol
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A screening system to identify transcription factors that induce binding site-directed DNA demethylation.
Epigenetics Chromatin
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Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c.
Nat Commun
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Biosci Biotechnol Biochem
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A Single Vector Platform for High-Level Gene Transduction of Central Neurons: Adeno-Associated Virus Vector Equipped With the Tet-Off System
PLoS One
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Sci Rep
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Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures
PLoS Onec
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A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling
Mol Psychiatry
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Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy
Invest Ophthalmol Vis Sci
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AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG
Sci Rep
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Peptides
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Development of a double-stranded siRNA labelling method by using 99m Tc and single photon emission computed tomography imaging
J Drug Target
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Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na v 1.1 to Na v 1.7)
Br J Pharmacol
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Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells
Stem Cells
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Towards water-free biobanks: long-term dry-preservation at room temperature of desiccation-sensitive enzyme luciferase in air-dried insect cells
Sci Rep
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Synthesis and optimization of novel α-phenylglycinamides as selective TRPM8 antagonists
Bioorg Med Chem
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Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons
J Gen Virol
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In vivo brain activity imaging of interactively locomoting mice
bioRxiv
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Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a
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Nat Commun
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Forward-genetics analysis of sleep in randomly mutagenized mice.
Nature
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Nat Commun
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Neuroscience
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Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion
J Biol Chem
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Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic Tardigrade improve osmotic tolerance of human cells
PLoS One
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Nat Commun
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9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α
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Exp Hematol
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Cell Cycle
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Nat Genet
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Retrovirology
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Hum Gene Ther Methods
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Haruta M, Tomita Y, Yuno A, Matsumura K, Ikeda T, Takamatsu K, Haga E, Koba C, Nishimura Y, Senju S.
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Two Novel Heat-Soluble Protein Families Abundantly Expressed in an Anhydrobiotic Tardigrade
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J Cell Physiol
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PLoS ONE
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Ayako Kataoka, Yui Koga, Ayumi Uesugi, Hidetoshi Tozaki-Saitoh, Makoto Tsuda, Kazuhide Inoue
Involvement of vasodilator-stimulated phosphoprotein in UDP-induced microglial actin aggregation via PKC- and Rho-dependent pathways
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Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
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Genotypic Effect of ABCG1 gene promoter -257T>G polymorphism on coronary artery disease severity in Japanese men
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Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis
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PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B.
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Modulation of TNF-alpha-converting Enzyme by the Spike Protein of SARS-CoV and ACE2 Induces TNF-alpha Production and Facilitates Viral Entry
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Frizzled-7 as a potential therapeutic target in colorectal cancer
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Excess magnesium inhibits excess calcium-induced matrix-mineralization and production of matrix gla protein (MGP) by ATDC5 cells.
Biochem Biophys Res Commun
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