CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2202 : 293T]

3489 DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol Cell Biol 1987 7(1):379-87 PubMed ID: 3031469 DOI: 10.1128/mcb.7.1.379

4972 Graham FL, Harrison T, Williams J. Defective transforming capacity of adenovirus type 5 host-range mutants. Virology 1978 86(1):10-21 PubMed ID: 664220 DOI: 10.1016/0042-6822(78)90003-x

2415 Harrison T, Graham F, Williams J Host-range mutants of adenovirus type 5 defective for growth in HeLa cells. Virology 1977 77:319-29 PubMed ID: 841862 DOI: 10.1016/0042-6822(77)90428-7

2414 Graham, F L, Smiley J, Russell, W C, Nairn R Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977 36:59-74 PubMed ID: 886304 DOI: 10.1099/0022-1317-36-1-59

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19760 etta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Tomoko Honjo, Yoshihiko Sakaguchi, Akira Yamauchi, Futoshi Kuribayashi, Eisaku Kondo, Yusuke Inoue, Junichiro Futami, Shinichi Toyooka, Yoshito Zamami, Masakiyo Sakaguchi Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface Frontiers in Oncology 2024 14 DOI: 10.3389/fonc.2024.1371342

19794 Nakanishi-Matsui M, Matsumoto N, Sun-Wada GH, Wada Y. Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the Interaction with Rab7 and Secretory Lysosome Trafficking in Osteoclasts Biol Pharm Bull 2024 47(1):339-344 PubMed ID: 38296463 DOI: 10.1248/bpb.b23-00833

19818 Gong L, Voon DC, Nakayama J, Takahashi C, Kohno S. RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells Cancer Sci 2024 Mar 11 PubMed ID: 38468443 DOI: 10.1111/cas.16122

21591 Katayama M, Murakami S, Ishida H, Matsugo H, Sekine W, Ohira K, Takenaka-Uema A, Horimoto T. Antigenic commonality and divergence of hemagglutinin-esterase-fusion protein among influenza D virus lineages revealed using epitope mapping. J Virol 2024 e0190823 PubMed ID: 38345383 DOI: 10.1128/jvi.01908-23

21592 Ito F, Yanatori I, Kato K, Toyokuni S. Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models. STAR Protoc 2024 5(1):102892 PubMed ID: 38363686 DOI: 10.1016/j.xpro.2024.102892

21618 Kohyanagi N, Kitamura N, Ikeda S, Shibutani S, Sato K, Ohama T. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. J Biol Chem 2024 300(1):105584 PubMed ID: 38141761 DOI: 10.1016/j.jbc.2023.105584

21654 Kobayashi H, Shiba T, Yoshida T, Bolidong D, Kato K, Sato Y, Mochizuki M, Seto T, Kawashiri S, Hanayama R. Precise analysis of single small extracellular vesicles using flow cytometry. Sci Rep 2024 14(1):7465 PubMed ID: 38553534 DOI: 10.1038/s41598-024-57974-3

21667 Kim YJ, Tohyama S, Nagashima T, Nagase M, Hida Y, Hamada S, Watabe AM, Ohtsuka T. A light-controlled phospholipase C for imaging of lipid dynamics and controlling neural plasticity. Cell Chem Biol 2024 PubMed ID: 38582083 DOI: 10.1016/j.chembiol.2024.03.001

21699 Suzuki N, Konuma T, Ikegami T, Akashi S. Biophysical insights into the dimer formation of human Sirtuin 2. Protein Sci 2024 33(5):e4994 PubMed ID: 38647411 DOI: 10.1002/pro.4994

21733 Fujii T, Liang L, Nakayama K, Katoh Y. Defects in diffusion barrier function of ciliary transition zone caused by ciliopathy variations of TMEM218. Hum Mol Genet 2024 PubMed ID: 38751342 DOI: 10.1093/hmg/ddae083

21738 Otsuka Y, Imamura K, Oishi A, Asakawa K, Kondo T, Nakai R, Suga M, Inoue I, Sagara Y, Tsukita K, Teranaka K, Nishimura Y, Watanabe A, Umeyama K, Okushima N, Mitani K, Nagashima H, Kawakami K, Muguruma K, Tsujikawa A, Inoue H. Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction JCI Insight 2024 9(8):e174179 PubMed ID: 38646933 DOI: 10.1172/jci.insight.174179

21753 Tachibana K, Nakamura Y, Do TL, Kihara T, Kawada H, Yamamoto N, Ando K. Mutations in the SARS-cov-2 spike proteins affected the ACE2-binding affinity during the development of omicron pandemic variants. Biochem Biophys Res Commun 2024 719:150120 PubMed ID: 38759524 DOI: 10.1016/j.bbrc.2024.150120

21781 Kitano M, Ohnishi H, Makino A, Miyamoto T, Hayashi Y, Mizuno K, Kaba S, Kawai Y, Kojima T, Kishimoto Y, Yamamoto N, Tomonaga K, Omori K. An infection model for SARS-CoV-2 using rat transplanted with hiPSC-airway epithelial cells. Tissue Eng Part A 2024 PubMed ID: 38832872 DOI: 10.1089/ten.TEA.2024.0016

21812 Yu H, Kohno S, Voon DC, Hussein NH, Zhang Y, Nakayama J, Takegami Y, Takahashi C. RECK/GPR124-driven WNT signaling in pancreatic and gastric cancer cells. Cancer Sci 2024 PubMed ID: 38923741 DOI: 10.1111/cas.16258

21871 Sugiyama Y, Okada S, Daigaku Y, Kusumoto E, Ito T. Strategic targeting of Cas9 nickase induces large segmental duplications. Cell Genom 2024 PubMed ID: 39053455 DOI: 10.1016/j.xgen.2024.100610

21913 Ueno K, Kurazumi H, Suzuki R, Yanagihara M, Mizoguchi T, Harada T, Morikage N, Hamano K. miR-709 exerts an angiogenic effect through a FGF2 upregulation induced by a GSK3B downregulation Sci Rep 2024 14(1):11372 PubMed ID: 38762650 DOI: 10.1038/s41598-024-62340-4

21920 Sekine W, Kamiki H, Ishida H, Matsugo H, Ohira K, Li K, Katayama M, Takenaka-Uema A, Murakami S, Horimoto T. Adaptation potential of H3N8 canine influenza virus in human respiratory cells. Sci Rep 2024 14(1):18750 PubMed ID: 39138310 DOI: 10.1038/s41598-024-69509-x

21932 Miyahara S, Ohuchi M, Nomura M, Hashimoto E, Soga T, Saito R, Hayashi K, Sato T, Saito M, Yamashita Y, Shimada M, Yaegashi N, Yamada H, Tanuma N. FDX2, an iron-sulfur cluster assembly factor, is essential to prevent cellular senescence, apoptosis or ferroptosis of ovarian cancer cells. J Biol Chem 2024 107678 PubMed ID: 39151727 DOI: 10.1016/j.jbc.2024.107678

21934 Tabata K, Kobayashi S, Itakura Y, Gonzalez G, Kabamba CF, Saito S, Sasaki M, Hall WW, Sawa H, Orba Y. Increased production of orthoflavivirus single-round infectious particles produced in mammalian cells at a suboptimal culture temperature of 28°C. J Virol Methods 2024 115007 PubMed ID: 39154937 DOI: 10.1016/j.jviromet.2024.115007

21935 Wang Y, Moh-Moh-Aung A, Wang T, Fujisawa M, Ohara T, Yamamoto KI, Sakaguchi M, Yoshimura T, Matsukawa A. Exosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis. Gene 2024 148874 PubMed ID: 39159792 DOI: 10.1016/j.gene.2024.148874

21952 Chiu CT, Tsai HH, Chen JY, Hu CJ, Chen HW. An Immunoreceptor-Targeting Strategy with Minimalistic C3b Peptide Fusion Enhances SARS-CoV-2 RBD mRNA Vaccine Immunogenicity. Int J Nanomedicine 2024 19:7201-7214 PubMed ID: 39050877 DOI: 10.2147/IJN.S463546

21956 Ueno M, Sugiyama H, Li F, Nishimura T, Arakawa H, Chen X, Cheng X, Takeuchi S, Takeshita Y, Takamura T, Miyagi S, Toyama T, Soga T, Masuo Y, Kato Y, Nakamura H, Tsujiguchi H, Hara A, Tajima A, Noguchi-Shinohara M, Ono K, Kurayoshi K, Kobayashi M, Tadokoro Y, Kasahara A, Shoulkamy MI, Maeda K, Ogoshi T, Hirao A. A Supramolecular Biosensor for Rapid and High-Throughput Quantification of a Disease-Associated Niacin Metabolite. Anal Chem 2024 PubMed ID: 39183562 DOI: 10.1021/acs.analchem.4c02653

21967 Okada M, Yamasaki S, Nakazato H, Hirahara Y, Ishibashi T, Kawamura M, Shimizu K, Fujii SI. ARID1A-Deficient Tumors Acquire Immunogenic Neoantigens during the Development of Resistance to Targeted Therapy. Cancer Res 2024 84(17):2792-2805 PubMed ID: 39228255 DOI: 10.1158/0008-5472.CAN-23-2846

21975 Koike T, Sato T, Oe S, Hayashi S, Seki-Omura R, Nakano Y, Iwashita H, Sato Y, Hirahara Y, Kitada M. CD34 distribution in C-fiber low threshold mechanoreceptors in the mouse dorsal root ganglion and spinal cord. Brain Res 2024 1846:149227 PubMed ID: 39255903 DOI: 10.1016/j.brainres.2024.149227

21979 Mori S, Kohyama M, Yasumizu Y, Tada A, Tanzawa K, Shishido T, Kishida K, Jin H, Nishide M, Kawada S, Motooka D, Okuzaki D, Naito R, Nakai W, Kanda T, Murata T, Terao C, Ohmura K, Arase N, Kurosaki T, Fujimoto M, Suenaga T, Kumanogoh A, Sakaguchi S, Ogawa Y, Arase H. Neoself-antigens are the primary target for autoreactive T cells in human lupus. Cell 2024 PubMed ID: 39276775 DOI: 10.1016/j.cell.2024.08.025

21993 Kashiwagi M, Beck G, Kanuka M, Arai Y, Tanaka K, Tatsuzawa C, Koga Y, Saito YC, Takagi M, Oishi Y, Sakaguchi M, Baba K, Ikuno M, Yamakado H, Takahashi R, Yanagisawa M, Murayama S, Sakurai T, Sakai K, Nakagawa Y, Watanabe M, Mochizuki H, Hayashi Y. A pontine-medullary loop crucial for REM sleep and its deficit in Parkinson's disease. Cell 2024 PubMed ID: 39303715 DOI: 10.1016/j.cell.2024.08.046

22065 Nagai N, Shioiri T, Hatano S, Sugiura N, Watanabe H. Regulatory role of Heparan sulfate in leptin signaling. Cell Signal 2024 124:111456 PubMed ID: 39384005 DOI: 10.1016/j.cellsig.2024.111456

22066 Saji T, Endo M, Okada Y, Minami Y, Nishita M. KIF1C facilitates retrograde transport of lysosomes through Hook3 and dynein. Commun Biol 2024 7(1):1305 PubMed ID: 39394274 DOI: 10.1038/s42003-024-07023-6

22154 Matsuzaki Y, Fukai Y, Konno A, Hirai H. Optimal different adeno-associated virus capsid/promoter combinations to target specific cell types in the common marmoset cerebral cortex. Mol Ther Methods Clin Dev 2024 32(4):101337 PubMed ID: 39391837 DOI: 10.1016/j.omtm.2024.101337

22165 Kanadome T, Hoshino N, Nagai T, Yagi T, Matsuda T. Protocol to visualize trans-interaction of clustered protocadherin using cIPAD, a fluorescent indicator, in cultured human cells and mouse neurons. STAR Protoc 2024 5(1):102844 PubMed ID: 38277267 DOI: 10.1016/j.xpro.2024.102844

17565 Arai Y, Yamanaka I, Okamoto T, Isobe A, Nakai N, Kamimura N, Suzuki T, Daidoji T, Ono T, Nakaya T, Matsumoto K, Okuzaki D, Watanabe Y. Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists iScience 2023 26(1):105742 PubMed ID: 36507221 DOI: 10.1016/j.isci.2022.105742

17804 Toshiki Takahashi, Jun Shirai, Miyo Matsuda, Sae Nakanaga, Shin Matsushita, Kei Wakita, Mizuki Hayashishita, Rigel Suzuki, Aya Noguchi, Naoto Yokota, and Hiroyuki Kawahara Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8- family GTPases iScience 2023 DOI: 10.1016/ j.isci.2023.106652

18094 Nakajima M, Kawahara R, Simizu S. Cofilin promotes vasculogenic mimicry by regulating the actin cytoskeleton in human breast cancer cells FEBS Lett 2023 597(8):1114-1124 PubMed ID: 36737242 DOI: 10.1002/1873-3468.14594

18098 Gohara Y, Tomonobu N, Kinoshita R, Futami J, Audebert L, Chen Y, Komalasari NLGY, Jiang F, Yoshizawa C, Murata H, Yamamoto KI, Watanabe M, Kumon H, Sakaguchi M. Novel extracellular role of REIC/Dkk-3 protein in PD-L1 regulation in cancer cells J Mol Med (Berl) 2023 101(4):431-447 PubMed ID: 36869893 DOI: 10.1007/s00109-023-02292-w

18106 Komalasari NLGY, Tomonobu N, Kinoshita R, Chen Y, Sakaguchi Y, Gohara Y, Jiang F, Yamamoto KI, Murata H, Ruma IMW, Sumardika IW, Zhou J, Yamauchi A, Kuribayashi F, Inoue Y, Toyooka S, Sakaguchi M. Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2 Front Oncol 2023 13:1142907 PubMed ID: 37091157 DOI: 10.3389/fonc.2023.1142907

18139 Hoshino N, Kanadome T, Takasugi T, Itoh M, Kaneko R, Inoue YU, Inoue T, Hirabayashi T, Watanabe M, Matsuda T, Nagai T, Tarusawa E, Yagi T. Visualization of trans homophilic interaction of clustered protocadherin in neurons Proc Natl Acad Sci U S A 2023 120(38):e2301003120 PubMed ID: 37695902 DOI: 10.1073/pnas.2301003120

18171 Kikuchi M, Takase S, Konuma T, Noritsugu K, Sekine S, Ikegami T, Ito A, Umehara T. GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain Proc Natl Acad Sci U S A 2023 120(43):e2304103120 PubMed ID: 37844223 DOI: 10.1073/pnas.2304103120

19540 Furukawa Y, Ishii M, Ando J, Ikeda K, Igarashi KJ, Kinoshita S, Azusawa Y, Toyota T, Honda T, Nakanishi M, Ohshima K, Masuda A, Yoshida E, Kitade M, Porteus M, Terao Y, Nakauchi H, Ando M. iPSC-derived hypoimmunogenic tissue resident memory T cells mediate robust anti-tumor activity against cervical cancer Cell Rep Med 2023 4(12):101327 PubMed ID: 38091985 DOI: 10.1016/j.xcrm.2023.101327

19549 Uemura K, Nobori H, Sato A, Toba S, Kusakabe S, Sasaki M, Tabata K, Matsuno K, Maeda N, Ito S, Tanaka M, Anraku Y, Kita S, Ishii M, Kanamitsu K, Orba Y, Matsuura Y, Hall WW, Sawa H, Kida H, Matsuda A, Maenaka K. 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses Proc Natl Acad Sci U S A 2023 120(42):e2304139120 PubMed ID: 37831739 DOI: 10.1073/pnas.2304139120

19597 Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A. The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis Sci Rep 2023 13(1):14405 PubMed ID: 37658135 DOI: 10.1038/s41598-023-41492-9

19624 Park G, Fukasawa K, Horie T, Masuo Y, Inaba Y, Tatsuno T, Yamada T, Tokumura K, Iwahashi S, Iezaki T, Kaneda K, Kato Y, Ishigaki Y, Mieda M, Tanaka T, Ogawa K, Ochi H, Sato S, Shi YB, Inoue H, Lee H, Hinoi E. l-Type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis JCI Insight 2023 8(7):e154925 PubMed ID: 36862514 DOI: 10.1172/jci.insight.154925

19632 ukasawa K, Lyu J, Kubo T, Tanaka Y, Suzuki A, Horie T, Tomizawa A, Osumi R, Iwahashi S, Tokumura K, Murata M, Kobayashi M, Todo T, Hirao A, Hinoi E. MEK5-ERK5 Axis Promotes Self-renewal and Tumorigenicity of Glioma Stem Cells Cancer Res Commun 2023 3(1):148-159 PubMed ID: 36968222 DOI: 10.1158/2767-9764.CRC-22-0243

19650 Zhang S, Tsuji H, Jin H, Kitagori K, Akizuki S, Nakashima R, Yoshifuji H, Tanaka M, Arase H, Ohmura K, Morinobu A. Rheumatoid factor recognizes specific domains of the IgG heavy chain complexed with HLA class II molecules Rheumatology (Oxford) 2023 62(9):3151-3155. PubMed ID: 36645239 DOI: 10.1093/rheumatology/kead024

19789 Hagkarim NC, Hajkarim MC, Suzuki T, Fujiwara T, Winkler GS, Stewart GS, Grand RJ. Disruption of the Mammalian Ccr4-Not Complex Contributes to Transcription-Mediated Genome Instability Cells 2023 12(14):1868 PubMed ID: 37508532 DOI: 10.3390/cells12141868

19919 Wuputra K, Tsai MH, Kato K, Ku CC, Pan JB, Yang YH, Saito S, Wu CC, Lin YC, Cheng KH, Kuo KK, Noguchi M, Nakamura Y, Yoshioka T, Wu DC, Lin CS, Yokoyama KK. Jdp2 is a spatiotemporal transcriptional activator of the AhR via the Nrf2 gene battery Inflamm Regen 2023 43(1):42 PubMed ID: 37596694 DOI: 10.1186/s41232-023-00290-6

19958 Hirabayashi D, Yamamoto KI, Maruyama A, Tomonobu N, Kinoshita R, Chen Y, Komalasari NLGY, Murata H, Gohara Y, Jiang F, Zhou J, Ruma IMW, Sumardika IW, Yamauchi A, Kuribayashi F, Toyooka S, Inoue Y, Sakaguchi M. LOXL1 and LOXL4 are novel target genes of the Zn2+-bound form of ZEB1 and play a crucial role in the acceleration of invasive events in triple-negative breast cancer cells Front Oncol 2023 13:1142886 PubMed ID: 36910659 DOI: 10.3389/fonc.2023.1142886

19991 Mitamura R, Nakano M, Isono M, Kurosawa K, Fukami T, Nakajima M. NEAT1_2 and DAZAP1, Paraspeckle Components, Interact with PXR to Negatively Regulate CYP3A4 Induction Drug Metab Dispos 2023 51(10):1230-1237 PubMed ID: 37349114 DOI: 10.1124/dmd.122.001065

20922 Sasaki M, Tabata K, Kishimoto M, Itakura Y, Kobayashi H, Ariizumi T, Uemura K, Toba S, Kusakabe S, Maruyama Y, Iida S, Nakajima N, Suzuki T, Yoshida S, Nobori H, Sanaki T, Kato T, Shishido T, Hall WW, Orba Y, Sato A, Sawa H. S-217622, a SARS-CoV-2 main protease inhibitor, decreases viral load and ameliorates COVID-19 severity in hamsters. Sci Transl Med 2023 15(679):eabq4064 PubMed ID: 36327352 DOI: 10.1126/scitranslmed.abq4064

20993 Okamoto K, Kamikubo Y, Yamauchi K, Okamoto S, Takahashi M, Ishida Y, Koike M, Ikegaya Y, Sakurai T, Hioki H. Specific AAV2/PHP.eB-mediated gene transduction of CA2 pyramidal cells via injection into the lateral ventricle. Sci Rep 2023 13(1):323 PubMed ID: 36609635 DOI: 10.1038/s41598-022-27372-8

21011 Hiyamizu S, Qiu H, Vuolo L, Stevenson NL, Shak C, Heesom KJ, Hamada Y, Tsurumi Y, Chiba S, Katoh Y, Stephens DJ, Nakayama K. Multiple interactions of the dynein-2 complex with the IFT-B complex are required for effective IFT. J Cell Sci 2023 PubMed ID: 36632779 DOI: 10.1242/jcs.260462

21015 Shoji H, Kitao K, Miyazawa T, Nakagawa S. Potentially reduced fusogenicity of syncytin-2 in New World monkeys. FEBS Open Bio 2023 PubMed ID: 36647789 DOI: 10.1002/2211-5463.13555

21065 Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A. Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly. J Am Chem Soc 2023 145(1):135-142 PubMed ID: 36538570 DOI: 10.1021/jacs.2c08974

21076 Sato M, Maishi N, Hida Y, Yanagawa-Matsuda A, Alam MT, Sakakibara-Konishi J, Nam JM, Onodera Y, Konno S, Hida K. Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy. Cancer Med 2023 PubMed ID: 36808261 DOI: 10.1002/cam4.5696

21092 Yoshimoto S, Suzuki T, Otani N, Takahashi D, Toshima K, Dohmae N, Simizu S. Destabilization of vitelline membrane outer layer protein 1 homolog (VMO1) by C-mannosylation. FEBS Open Bio 2023 PubMed ID: 36680395 DOI: 10.1002/2211-5463.13561

21101 Ota A, Morita H, Naganuma T, Miyamoto M, Jojima K, Nojiri K, Matsuda J, Kihara A. Bifunctional DEGS2 has higher hydroxylase activity toward substrates with very-long-chain fatty acids in the production of phytosphingosine-ceramides. J Biol Chem 2023 104603 PubMed ID: 36907437 DOI: 10.1016/j.jbc.2023.104603

17485 Tanikawa S, Ebisu Y, Sedlačík T, Semba S, Nonoyama T, Kurokawa T, Hirota A, Takahashi T, Yamaguchi K, Imajo M, Kato H, Nishimura T, Tanei ZI, Tsuda M, Nemoto T, Gong JP, Tanaka S. Engineering of an electrically charged hydrogel implanted into a traumatic brain injury model for stepwise neuronal tissue reconstruction Sci Rep 2023 13(1):2233 PubMed ID: 36788295 DOI: 10.1038/s41598-023-28870-z

21104 Kawano T, Kashiwagi M, Kanuka M, Chen CK, Yasugaki S, Hatori S, Miyazaki S, Tanaka K, Fujita H, Nakajima T, Yanagisawa M, Nakagawa Y, Hayashi Y. ER proteostasis regulators cell-non-autonomously control sleep. Cell Rep 2023 42(3):112267 PubMed ID: 36924492 DOI: 10.1016/j.celrep.2023.112267

21158 Tao F, Kitamura K, Hanada S, Sugimoto K, Furihata T, Kojima N. Rapid and Stable Formation Method of Human Astrocyte Spheroid in a High Viscous Methylcellulose Medium and Its Functional Advantages. Bioengineering (Basel) 2023 10(3) PubMed ID: 36978740 DOI: 10.3390/bioengineering10030349

21159 Watanabe T, Narahari A, Bhardwaj E, Kuriyama K, Nishimura M, Izumi T, Fujimuro M, Ohno S. Conserved cysteine residues in Kaposi's sarcoma herpesvirus ORF34 are necessary for viral production and viral pre-initiation complex formation. bioRxiv 2023 PubMed ID: 36945456 DOI: 10.1101/2023.03.08.531831

21179 Noritsugu K, Suzuki T, Dodo K, Ohgane K, Ichikawa Y, Koike K, Morita S, Umehara T, Ogawa K, Sodeoka M, Dohmae N, Yoshida M, Ito A. Lysine long-chain fatty acylation regulates the TEAD transcription factor. Cell Rep 2023 112388 PubMed ID: 37060904 DOI: 10.1016/j.celrep.2023.112388

21219 Jojima K, Kihara A. Metabolism of sphingadiene and characterization of the sphingadiene-producing enzyme FADS3. Biochim Biophys Acta Mol Cell Biol Lipids 2023 1868(8):159335 PubMed ID: 37209771 DOI: 10.1016/j.bbalip.2023.159335

21222 Takahashi T, Shirai J, Matsuda M, Nakanaga S, Matsushita S, Wakita K, Hayashishita M, Suzuki R, Noguchi A, Yokota N, Kawahara H. Protein quality control machinery supports primary ciliogenesis by eliminating GDP-bound Rab8-family GTPases. iScience 2023 26(5):106652 PubMed ID: 37182096 DOI: 10.1016/j.isci.2023.106652

21248 Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS. FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA. Proc Natl Acad Sci U S A 2023 120(24):e2218955120 PubMed ID: 37279268 DOI: 10.1073/pnas.2218955120

21258 Nishi K, Yoshii A, Abell L, Zhou B, Frausto R, Ritterhoff J, McMillen TS, Sweet I, Wang Y, Gao C, Tian R. Branched-chain keto acids inhibit mitochondrial pyruvate carrier and suppress gluconeogenesis in hepatocytes. Cell Rep 2023 42(6):112641 PubMed ID: 37310861 DOI: 10.1016/j.celrep.2023.112641

21261 Hiyamizu S, Qiu H, Tsurumi Y, Hamada Y, Katoh Y, Nakayama K. Dynein-2-driven intraciliary retrograde trafficking indirectly requires multiple interactions of IFT54 in the IFT-B complex with the dynein-2 complex. Biol Open 2023 PubMed ID: 37309605 DOI: 10.1242/bio.059976

21265 Shimohata A, Rai D, Akagi T, Usui S, Ogiwara I, Kaneda M. The intracellular C-terminal domain of mGluR6 contains ER retention motifs. Mol Cell Neurosci 2023 103875 PubMed ID: 37352898 DOI: 10.1016/j.mcn.2023.103875

21270 Yamaguchi S, Kamino M, Hamamura M, Otsuguro KI. The cytosolic N-terminal region of heterologously-expressed transmembrane channel-like protein 1 (TMC1) can be cleaved in HEK293 cells. PLoS One 2023 18(6):e0287249 PubMed ID: 37352201 DOI: 10.1371/journal.pone.0287249

21278 Okada M, Shimizu K, Nakazato H, Yamasaki S, Fujii SI. Detection of mutant antigen-specific T cell receptors against multiple myeloma for T cell engineering. Mol Ther Methods Clin Dev 2023 29:541-555 PubMed ID: 37359417 DOI: 10.1016/j.omtm.2023.05.014

21285 Morishita K, Kondo J, Sakon D, Hayashibara A, Tamura I, Shimizu K, Takamatsu S, Murata K, Kamada Y, Miyoshi E. Prohaptoglobin is a possible prognostic biomarker for colorectal cancer. Biochem Biophys Res Commun 2023 672:72-80 PubMed ID: 37343317 DOI: 10.1016/j.bbrc.2023.06.017

21309 Tanaka Y, Morozumi A, Hirokawa N. Nodal flow transfers polycystin to determine mouse left-right asymmetry. Dev Cell 2023 PubMed ID: 37413993 DOI: 10.1016/j.devcel.2023.06.002

21312 Omata K, Nomura I, Hirata A, Yonezuka Y, Muto H, Kuriki R, Jimbo K, Ogasa K, Kato T. Isolation and evaluation of erythroid progenitors in the livers of larval, froglet, and adult Xenopus tropicalis. Biol Open 2023 PubMed ID: 37421150 DOI: 10.1242/bio.059862

21316 Matsuura-Suzuki E, Toh H, Iwasaki S. Human-rabbit Hybrid Translation System to Explore the Function of Modified Ribosomes. Bio Protoc 2023 13(13):e4714 PubMed ID: 37456340 DOI: 10.21769/BioProtoc.4714

21317 Tokuma H, Sakano D, Tanabe K, Tanizawa Y, Shiraki N, Kume S. Selective proteasome degradation of C-terminally-truncated human WFS1 in pancreatic beta cells. FEBS Open Bio 2023 PubMed ID: 37440664 DOI: 10.1002/2211-5463.13674

21326 Takahashi G, Miyaoka Y. Large-scale single-cell cloning of genome-edited cultured human cells by On-chip SPiS. STAR Protoc 2023 4(3):102364 PubMed ID: 37329509 DOI: 10.1016/j.xpro.2023.102364

21335 Goto M, Nishimura G, Sato H, Yamaguchi Y, Morimoto N, Hashimoto H, Takahashi N. Pharmacological profile of upacicalcet, a novel positive allosteric modulator of calcium-sensing receptor, in vitro and in vivo. Eur J Pharmacol 2023 175936 PubMed ID: 37541363 DOI: 10.1016/j.ejphar.2023.175936

21345 Komuro H, Shinohara S, Fukushima Y, Demachi-Okamura A, Muraoka D, Masago K, Matsui T, Sugita Y, Takahashi Y, Nishida R, Takashima C, Ohki T, Shigematsu Y, Watanabe F, Adachi K, Fukuyama T, Hamana H, Kishi H, Miura D, Tanaka Y, Onoue K, Onoguchi K, Yamashita Y, Stratford R, Clancy T, Yamaguchi R, Kuroda H, Doi K, Iwata H, Matsushita H. Single-cell sequencing on CD8+ TILs revealed the nature of exhausted T cells recognizing neoantigen and cancer/testis antigen in non-small cell lung cancer. J Immunother Cancer 2023 11(8) PubMed ID: 37544663 DOI: 10.1136/jitc-2023-007180

21353 Kanadome T, Hoshino N, Nagai T, Yagi T, Matsuda T. Visualization of trans-interactions of a protocadherin-α between processes originating from single neurons. iScience 2023 26(7):107238 PubMed ID: 37534169 DOI: 10.1016/j.isci.2023.107238

21367 Tsuji K, Kikuchi E, Takashima Y, Shoji T, Takahashi H, Ito S, Morinaga D, Kashima M, Maeda M, Kitai H, Kikuchi J, Sakakibara-Konishi J, Konno S. Inhibition of non-homologous end joining mitigates paclitaxel resistance resulting from mitotic slippage in non-small cell lung cancer Cell Cycle 2023 22(17):1854-1864 PubMed ID: 37592765 DOI: 10.1080/15384101.2023.2243761

21373 Suzuki MM, Iijima K, Ogami K, Shinjo K, Murofushi Y, Xie J, Wang X, Kitano Y, Mamiya A, Kibe Y, Nishimura T, Ohka F, Saito R, Sato S, Kobayashi J, Yao R, Miyata K, Kataoka K, Suzuki HI, Kondo Y. TUG1-mediated R-loop resolution at microsatellite loci as a prerequisite for cancer cell proliferation. Nat Commun 2023 14(1):4521 PubMed ID: 37607907 DOI: 10.1038/s41467-023-40243-8

21382 Xu J, Hashino T, Tanaka R, Kawaguchi K, Yoshida H, Kataoka T. The BCL-2 family protein BCL-RAMBO interacts and cooperates with GRP75 to promote its apoptosis signaling pathway. Sci Rep 2023 13(1):14041 PubMed ID: 37640805 DOI: 10.1038/s41598-023-41196-0

21398 Kanao E, Ishida K, Mizuta R, Li Y, Imami K, Tanigawa T, Sasaki Y, Akiyoshi K, Adachi J, Otsuka K, Ishihama Y, Kubo T. Rapid and Highly Efficient Purification of Extracellular Vesicles Enabled by a TiO2 Hybridized Spongy-like Polymer. Anal Chem 2023 PubMed ID: 37703188 DOI: 10.1021/acs.analchem.3c03411

21416 Sogawa A, Komori R, Yanagitani K, Ohfurudono M, Tsuru A, Kadoi K, Kimata Y, Yoshida H, Kohno K. Signal sequence-triage is activated by translocon obstruction sensed by an ER stress sensor IRE1α. Cell Struct Funct 2023 PubMed ID: 37766570 DOI: 10.1247/csf.23072

21472 Takeuchi K, Tabe S, Takahashi K, Aoshima K, Matsuo M, Ueno Y, Furukawa Y, Yamaguchi K, Ohtsuka M, Morinaga S, Miyagi Y, Yamaguchi T, Tanimizu N, Taniguchi H. Incorporation of human iPSC-derived stromal cells creates a pancreatic cancer organoid with heterogeneous cancer-associated fibroblasts. Cell Rep 2023 42(11):113420 PubMed ID: 37955987 DOI: 10.1016/j.celrep.2023.113420

21501 Nishida H, Kanao E, Ishihama Y. Centrifugal Gel Crushing Tips for Gel-Based Proteome Analysis. Anal Chem 2023 PubMed ID: 38055789 DOI: 10.1021/acs.analchem.3c02527

21514 Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y, Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N, Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI, Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N. Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma. Nat Commun 2023 14(1):8095 PubMed ID: 38092728 DOI: 10.1038/s41467-023-43630-3

21660 Agata A, Ohtsuka S, Noji R, Gotoh H, Ono K, Nomura T. A Neanderthal/Denisovan GLI3 variant contributes to anatomical variations in mice. Front Cell Dev Biol 2023 2:11:1247361. PubMed ID: 38020913 DOI: 10.3389/fcell.2023.1247361

21852 Mizuta H, Takakusaki A, Suzuki T, Otake K, Dohmae N, Simizu S. C-mannosylation regulates stabilization of RAMP1 protein and RAMP1-mediated cell migration FEBS J 2023 290(1):196-208 PubMed ID: 35942636 DOI: 10.1111/febs.16592

17502 Haraguchi-Suzuki K, Kawabata-Iwakawa R, Suzuki T, Suto T, Takazawa T, Saito S. Local anesthetic lidocaine induces growth suppression of HeLa cells by decreasing and changing the cellular localization of the proliferation marker Ki-67 Genes Cells 2022 27(11):675-684 PubMed ID: 36074048 DOI: 10.1111/gtc.12983

17510 Miku Akishino, Yuko Aoki, Hajime Baba, Makio Asakawa, Yoichiro Hama, Susumu Mitsutake Red algae-derived isofloridoside activates the sweet taste receptor T1R2/T1R3 Food Bioscience 2022 50:102186 DOI: 10.1016/j.fbio.2022.102186

17529 Tsukida K, Muramatsu SI, Osaka H, Yamagata T, Muramatsu K. WDR45 variants cause ferrous iron loss due to impaired ferritinophagy associated with nuclear receptor coactivator 4 and WD repeat domain phosphoinositide interacting protein 4 reduction Brain Commun 2022 4(6):fcac304 PubMed ID: 36751498 DOI: 10.1093/braincomms/fcac304

17581 Kamiki H, Murakami S, Nishikaze T, Hiono T, Igarashi M, Furuse Y, Matsugo H, Ishida H, Katayama M, Sekine W, Muraki Y, Takahashi M, Takenaka-Uema A, Horimoto T. Influenza A Virus Agnostic Receptor Tropism Revealed Using a Novel Biological System with Terminal Sialic Acid Knockout Cells J Virol 2022 96(15):e0041622 PubMed ID: 35862707 DOI: 10.1128/jvi.00416-22

17616 Yamashita F, Kaieda T, Shimomura T, Kawaguchi M, Lin CY, Johnson MD, Tanaka H, Kiwaki T, Fukushima T, Kataoka H. Role of the polycystic kidney disease domain in matriptase chaperone activity and localization of hepatocyte growth factor activator inhibitor-1 FEBS J 2022 289(12):3422-3439 PubMed ID: 35020274 DOI: 10.1111/febs.16348

17620 Saito S, Funayama K, Kato W, Okuda M, Kawamoto M, Matsubara T, Sato T, Sato A, Otsuguro S, Sasaki M, Orba Y, Sawa H, Maenaka K, Shindo K, Imoto M, Arai MA. Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses J Nat Prod 2022 85(11):2583-2591 PubMed ID: 36223390 DOI: 10.1021/acs.jnatprod.2c00550

17651 Wei Z, Shimizu K, Sarii RS, Muthusinghe DS, Lokupathirage SMW, Nio-Kobayashi J, Yoshimatsu K. Pathological Studies on Hantaan Virus-Infected Mice Simulating Severe Hemorrhagic Fever with Renal Syndrome Viruses 2022 14(10):2247 PubMed ID: 36298802 DOI: 10.3390/v14102247

17675 Yamauchi K, Okamoto S, Ishida Y, Konno K, Hoshino K, Furuta T, Takahashi M, Koike M, Isa K, Watanabe M, Isa T, Hioki H. Fluorochromized tyramide-glucose oxidase as a multiplex fluorescent tyramide signal amplification system for histochemical analysis Sci Rep 2022 12(1):14807 PubMed ID: 36097273 DOI: 10.1038/s41598-022-19085-9

17714 Matsumura Y, To TK, Kunieda T, Kohno H, Kakutani T, Kubo T. Mblk-1/E93, an ecdysone related-transcription factor, targets synaptic plasticity-related genes in the honey bee mushroom bodies Sci Rep 2022 12(1):21367 PubMed ID: 36494426 DOI: 10.1038/s41598-022-23329-z

17783 Ohshima T, Yamamoto H, Sakamaki Y, Saito C, Mizushima N. NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy J Cell Biol 2022 221(10):e202203102 PubMed ID: 36066504 DOI: 10.1083/jcb.202203102

17788 Takeuchi Y, Ushimaru K, Kaneda K, Maruyama C, Ito T, Yamanaka K, Ogasawara Y, Katano H, Kato Y, Dairi T, Hamano Y. First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria Commun Biol 2022 5(1):1132 PubMed ID: 36289442 DOI: 10.1038/s42003-022-04110-4

19238 Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, Yamamoto T. Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2 RNA Biol 2022 19(1):234-246 PubMed ID: 35129087 DOI: 10.1080/15476286.2021.2021676

19240 Narita M, Denk T, Matsuo Y, Sugiyama T, Kikuguchi C, Ito S, Sato N, Suzuki T, Hashimoto S, Machová I, Tesina P, Beckmann R, Inada T. A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation Nat Commun 2022 13(1):6411 PubMed ID: 36302773 DOI: 10.1038/s41467-022-34097-9

20207 Tsuji H, Ohmura K, Jin H, Naito R, Arase N, Kohyama M, Suenaga T, Sakakibara S, Kochi Y, Okada Y, Yamamoto K, Kikutani H, Morinobu A, Mimori T, Arase H. Anti-dsDNA antibodies recognize DNA presented on HLA class II molecules of systemic lupus erythematosus risk alleles. Arthritis Rheumatol 2022 PubMed ID: 34164946 DOI: 10.1002/art.41897

20452 Tanaka K, Kandori S, Sakka S, Nitta S, Tanuma K, Shiga M, Nagumo Y, Negoro H, Kojima T, Mathis BJ, Shimazui T, Watanabe M, Sato TA, Miyamoto T, Matsuzaka T, Shimano H, Nishiyama H. ELOVL2 promotes cancer progression by inhibiting cell apoptosis in renal cell carcinoma. Oncol Rep 2022 47(2) PubMed ID: 34841437 DOI: 10.3892/or.2021.8234

20477 Arase N, Tsuji H, Takamatsu H, Jin H, Konaka H, Hamaguchi Y, Tonomura K, Kotobuki Y, Ueda-Hayakawa I, Matsuoka S, Hirano T, Yorifuji H, Murota H, Ohmura K, Nakashima R, Sato T, Kumanogoh A, Katayama I, Arase H, Fujimoto M. Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies. J Autoimmun 2022 126:102774 PubMed ID: 34896887 DOI: 10.1016/j.jaut.2021.102774

20517 Qiu H, Tsurumi Y, Katoh Y, Nakayama K. Combinations of deletion and missense variations of the dynein-2 DYNC2LI1 subunit found in skeletal ciliopathies cause ciliary defects. Sci Rep 2022 12(1):31 PubMed ID: 34997029 DOI: 10.1038/s41598-021-03950-0

20522 Hiraiwa M, Fukasawa K, Iezaki T, Sabit H, Horie T, Tokumura K, Iwahashi S, Murata M, Kobayashi M, Suzuki A, Park G, Kaneda K, Todo T, Hirao A, Nakada M, Hinoi E. SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability. Commun Biol 2022 5(1):22 PubMed ID: 35017630 DOI: 10.1038/s42003-021-02950-0

20524 Nomura T, Nagao K, Shirai R, Gotoh H, Umeda M, Ono K. Temperature sensitivity of Notch signaling underlies species-specific developmental plasticity and robustness in amniote brains. Nat Commun 2022 13(1):96 PubMed ID: 35013223 DOI: 10.1038/s41467-021-27707-5

16114 Wuputra K, Tsai MH, Kato K, Yang YH, Pan JB, Ku CC, Noguchi M, Kishikawa S, Nakade K, Chen HL, Liu CJ, Nakamura Y, Kuo KK, Lin YC, Chan TF, Wu DC, Hou MF, Huang SK, Lin CS, Yokoyama KK. Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts Cell Biol Toxicol 2022 Mar 15 PubMed ID: 33723743 DOI: 10.1007/s10565-021-09592-2

20588 Jin H, Kishida K, Arase N, Matsuoka S, Nakai W, Kohyama M, Suenaga T, Yamamoto K, Sasazuki T, Arase H. Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules. Sci Adv 2022 8(9):eabj9867 PubMed ID: 35245125 DOI: 10.1126/sciadv.abj9867

20597 Murakami Y, Masaki M, Miyazaki S, Oketani R, Hayashi Y, Yanagisawa M, Honjoh S, Kano H. Spectroscopic second and third harmonic generation microscopy using a femtosecond laser source in the third near-infrared (NIR-III) optical window. Biomed Opt Express 2022 13(2):694-708 PubMed ID: 35284173 DOI: 10.1364/BOE.446273

20641 Miyajima Y, Noguchi S, Tanaka Y, Li JR, Nishimura H, Kishima M, Lim J, Furuhata E, Suzuki T, Kasukawa T, Suzuki H. Prediction of transcription factors associated with DNA demethylation during human cellular development. Chromosome Res 2022 30(1):109-121 PubMed ID: 35142952 DOI: 10.1007/s10577-022-09685-6

20659 Chino H, Yamasaki A, Ode KL, Ueda HR, Noda NN, Mizushima N. Phosphorylation by casein kinase 2 enhances the interaction between ER-phagy receptor TEX264 and ATG8 proteins. EMBO Rep 2022 e54801 PubMed ID: 35417087 DOI: 10.15252/embr.202254801

20702 Nashimoto Y, Matsushita F, Dijkstra JM, Nakamura Y, Akiyama H, Hamako J, Morita T, Araki S, Matsui T. Bitiscetin-3, a Novel C-Type Lectin-like Protein Cloned from the Venom Gland of the Viper Bitis arietans, Induces Platelet Agglutination and Inhibits Binding of Von Willebrand Factor to Collagen. Toxins (Basel) 2022 14(4) PubMed ID: 35448845 DOI: 10.3390/toxins14040236

20704 Kamo H, Kawahara R, Simizu S. Tyrosinase suppresses vasculogenic mimicry in human melanoma cells. Oncol Lett 2022 23(5):169 PubMed ID: 35496574 DOI: 10.3892/ol.2022.13289

20713 Satoda Y, Noguchi T, Fujii T, Taniguchi A, Katoh Y, Nakayama K. BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to IFT turnaround involving ICK/CILK1. Mol Biol Cell 2022 mbcE22030089 PubMed ID: 35609210 DOI: 10.1091/mbc.E22-03-0089

16502 Kamada H, Yasuhira S, Shibazaki M, Amano H, Maesawa C. DUSP4 Inactivation Leads to Reduced Extracellular Signal‒Regulated Kinase Activity through Upregulation of DUSP6 in Melanoma Cells J Invest Dermatol 2022 S0022-202X(22)00126-9 PubMed ID: 35189148 DOI: 10.1016/j.jid.2022.02.007

20724 Yasui R, Matsui A, Sekine K, Okamoto S, Taniguchi H. Highly Sensitive Detection of Human Pluripotent Stem Cells by Loop-Mediated Isothermal Amplification. Stem Cell Rev Rep 2022 PubMed ID: 35661077 DOI: 10.1007/s12015-022-10402-3

20729 Ishida Y, Tasaki K, Katoh Y, Nakayama K. Molecular basis underlying the ciliary defects caused by IFT52 variations found in skeletal ciliopathies. Mol Biol Cell 2022 mbcE22050188 PubMed ID: 35704471 DOI: 10.1091/mbc.E22-05-0188

16632 Hada M, Miura H, Tanigawa A, Matoba S, Inoue K, Ogonuki N, Hirose M, Watanabe N, Nakato R, Fujiki K, Hasegawa A, Sakashita A, Okae H, Miura K, Shikata D, Arima T, Shirahige K, Hiratani I, Ogura A. Highly rigid H3.1/H3.2-H3K9me3 domains set a barrier for cell fate reprogramming in trophoblast stem cells Genes Dev 2022 36(1-2):84-102 PubMed ID: 34992147 DOI: 10.1101/gad.348782.121

16658 Sasaki K, Suzuki M, Sonoda T, Schneider-Poetsch T, Ito A, Takagi M, Fujishiro S, Sohtome Y, Dodo K, Umehara T, Aburatani H, Shin-Ya K, Nakao Y, Sodeoka M, Yoshida M. Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells Cell Chem Biol 2022 S2451-9456(22)00198-2 PubMed ID: 35728598 DOI: 10.1016/j.chembiol.2022.05.006

16659 Matsuura-Suzuki E, Shimazu T, Takahashi M, Kotoshiba K, Suzuki T, Kashiwagi K, Sohtome Y, Akakabe M, Sodeoka M, Dohmae N, Ito T, Shinkai Y, Iwasaki S. METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance Elife 2022 11:e72780 PubMed ID: 35674491 DOI: 10.7554/eLife.72780

20750 Yamada T, Fukasawa K, Horie T, Kadota T, Lyu J, Tokumura K, Ochiai S, Iwahashi S, Suzuki A, Park G, Ueda R, Yamamoto M, Kitao T, Shirahase H, Ochi H, Sato S, Iezaki T, Hinoi E. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis. Stem Cell Reports 2022 PubMed ID: 35777359 DOI: 10.1016/j.stemcr.2022.06.001

16732 Zhu Z, Kitano T, Morimatsu M, Tanaka A, Morioka R, Lin X, Orino K, Yoshikawa Y. BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents Int J Mol Sci 2022 23(7):4060 PubMed ID: 35409418 DOI: 10.3390/ijms23074060

16747 Fujii K, Morita S, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Yamaguchi K, Abe J, Yamazaki T, Imai T, Sugamura K, Yasuda J, Satoh K, Sato I, Saito-Koyama R, Fujishima F, Sasano H, Kato Y, Matsuura K, Asada Y, Tamai K. Establishment of a monoclonal antibody against glycosylated CD271 specific for cancer cells in immunohistochemistry Cancer Sci . 2022 Mar 28 2022 Mar 28 PubMed ID: 35343032 DOI: 10.1111/cas.15340

16748 Song W, Isaji T, Nakano M, Liang C, Fukuda T, Gu J. O-GlcNAcylation regulates β1,4-GlcNAc-branched N-glycan biosynthesis via the OGT/SLC35A3/GnT-IV axis FASEB J 2022 36(2):e22149 PubMed ID: 34981577 DOI: 10.1096/fj.202101520R

16749 Kitanishi T, Tashiro M, Kitanishi N, Mizuseki K. Intersectional, anterograde transsynaptic targeting of neurons receiving monosynaptic inputs from two upstream regions Commun Biol 2022 5(1):149 PubMed ID: 35190665 DOI: 10.1038/s42003-022-03096-3

16750 Otsuka K, Sawai-Ogawa M, Kihara A. Formation of fatty alcohols-components of meibum lipids-by the fatty acyl-CoA reductase FAR2 is essential for dry eye prevention FASEB J 2022 36(4):e22216 PubMed ID: 35238077 DOI: 10.1096/fj.202101733R

16765 Takahashi S, Shibutani S, Iwata H. Nuclear-targeted 4E-BP1 is dephosphorylated, induces nuclear translocation of eIF4E, and alters mRNA translation Exp Cell Res 2022 418(1):113246 PubMed ID: 35697076 DOI: 10.1016/j.yexcr.2022.113246

20788 Oishi T, Ito M, Koizumi S, Horikawa M, Yamamoto T, Yamagishi S, Yamasaki T, Sameshima T, Suzuki T, Sugimura H, Namba H, Kurozumi K. Efficacy of HSV-TK/GCV system suicide gene therapy using SHED expressing modified HSV-TK against lung cancer brain metastases. Mol Ther Methods Clin Dev 2022 26:253-265 PubMed ID: 35892087 DOI: 10.1016/j.omtm.2022.07.001

20822 Deai M, Oya R, Saso N, Tanaka A, Uchida I, Miyake Y, Tachihara R, Otsugu M, Mine A, Sato K, Tomura H. Ethylenediaminetetraacetic acid (EDTA) enhances cAMP production in human TDAG8-expressing cells. Biochem Biophys Res Commun 2022 626:15-20 PubMed ID: 35964552 DOI: 10.1016/j.bbrc.2022.07.110

17100 Izumi A, Yamamoto K, Kawaguchi M, Yamashita F, Fukushima T, Kiwaki T, Tanaka H, Yamashita Y, Kataoka H. Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells Cancer Sci 2022 113(6):2179-2193 PubMed ID: 35332604 DOI: 10.1111/cas.15346

20836 Kashio M, Masubuchi S, Tominaga M. Protein kinase C (PKC)-mediated phosphorylation of TRPM2 Thr738 counteracts the effect of cytosolic Ca2+ and elevates the temperature threshold. J Physiol 2022 PubMed ID: 36042566 DOI: 10.1113/JP283350

20845 Zhou Z, Katoh Y, Nakayama K. CEP19-RABL2-IFT-B axis controls BBSome-mediated ciliary GPCR export. Mol Biol Cell 2022 PubMed ID: 36074075 DOI: 10.1091/mbc.E22-05-0161

20857 Nohara T, Ohno Y, Kihara A. Impaired production of skin barrier lipid acylceramides and abnormal localization of PNPLA1 due to ichthyosis-causing mutations in PNPLA1. J Dermatol Sci 2022 107(2):89-94 PubMed ID: 35970721 DOI: 10.1016/j.jdermsci.2022.07.008

20869 Lyu X, Imai S, Yamano T, Hanayama R. Preventing SARS-CoV-2 Infection Using Anti-spike Nanobody-IFN-β Conjugated Exosomes. Pharm Res 2022 PubMed ID: 36163411 DOI: 10.1007/s11095-022-03400-0

20873 Yamamura N, Mikkaichi T, Itokawa KI, Hoshi M, Damme K, Geigner S, Baumhauer C. Mirogabalin, a novel α2δ ligand, is not a substrate of LAT1, but of PEPT1, PEPT2, OAT1, OAT3, OCT2, MATE1 and MATE2-K. Xenobiotica 2022 1-42 PubMed ID: 36170033 DOI: 10.1080/00498254.2022.2129517

20880 Kanadome T, Hayashi K, Seto Y, Eiraku M, Nakajima K, Nagai T, Matsuda T. Development of intensiometric indicators for visualizing N-cadherin interaction across cells. Commun Biol 2022 5(1):1065 PubMed ID: 36207396 DOI: 10.1038/s42003-022-04023-2

20892 Mang D, Mayu K, Toyama T, Yamagishi T, Sato R. BmGr4 responds to sucrose and glucose and expresses in tachykinin-related peptide-secreting enteroendocrine cells. Insect Biochem Mol Biol 2022 103858 PubMed ID: 36244651 DOI: 10.1016/j.ibmb.2022.103858

20906 Nakazato A, Mochizuki M, Shibuya-Takahashi R, Fujimori H, Fujii K, Saijoh S, Morita S, Yamazaki T, Imai T, Sato I, Satoh K, Yamaguchi K, Sugamura K, Yasuda J, Matsuura K, Shojaku H, Asada Y, Tamai K. RELA is required for CD271 expression and stem-like characteristics in hypopharyngeal cancer. Sci Rep 2022 12(1):17751 PubMed ID: 36273237 DOI: 10.1038/s41598-022-22736-6

20912 Kotani N, Nakano T, Kuwahara R. Host cell membrane proteins located near SARS-CoV-2 spike protein attachment sites are identified using proximity labeling and proteomic analysis. J Biol Chem 2022 298(11):102500 PubMed ID: 36152751 DOI: 10.1016/j.jbc.2022.102500

20914 Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, Hatakeyama S, Yamazaki S, Shimizu E, Imoto S, Furukawa Y, Yoshimura A, Nakanishi M. Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes. Nature 2022 PubMed ID: 36323784 DOI: 10.1038/s41586-022-05388-4

20926 Akiyama M, Unoki T, Aoki H, Nishimura A, Shinkai Y, Warabi E, Nishiyama K, Furumoto Y, Anzai N, Akaike T, Nishida M, Kumagai Y. Cystine-dependent antiporters buffer against excess intracellular reactive sulfur species-induced stress. Redox Biol 2022 57:102514 PubMed ID: 36279630 DOI: 10.1016/j.redox.2022.102514

17337 Sekine W, Takenaka-Uema A, Kamiki H, Ishida H, Matsugo H, Murakami S, Horimoto T. Adaptation of the H7N2 Feline Influenza Virus to Human Respiratory Cell Culture Viruses 2022 14(5):1091 PubMed ID: 35632832 DOI: 10.3390/v14051091

20971 Tatsumi A, Hirakochi H, Inoue S, Tanaka Y, Furuno H, Ikeda M, Ishibashi S, Taguchi T, Yamamoto K, Onishi I, Sachs Z, Largaespada DA, Kitagawa M, Kurata M. Identification of NRAS Downstream Genes with CRISPR Activation Screening. Biology (Basel) 2022 11(11) PubMed ID: 36358254 DOI: 10.3390/biology11111551

20975 Moriyama H, Moriyama M, Ozawa T, Tsuruta D, Hayakawa T. Differentiation of Human Adipose-Derived Mesenchymal Stromal/Stem Cells into Insulin-Producing Cells with A Single Tet-Off Lentiviral Vector System. Cell J 2022 24(12):705-714 PubMed ID: 36527342 DOI: 10.22074/cellj.2022.557533.1063

20998 Ozono T, Kimura Y, Suenaga T, Beck G, Jinno J, Aguirre C, Ikenaka K, Krainc D, Mochizuki H, Arase H. Extracellular transportation of α-synuclein by HLA class II molecules. Biochem Biophys Res Commun 2022 644:25-33 PubMed ID: 36621149 DOI: 10.1016/j.bbrc.2022.12.082

21033 Takahashi TM, Hirano A, Kanda T, Saito VM, Ashitomi H, Tanaka KZ, Yokoshiki Y, Masuda K, Yanagisawa M, Vogt KE, Tokuda T, Sakurai T. Optogenetic induction of hibernation-like state with modified human Opsin4 in mice. Cell Rep Methods 2022 2(11):100336 PubMed ID: 36452866 DOI: 10.1016/j.crmeth.2022.100336

21037 Takahashi M, Kobayashi T, Mizuma H, Yamauchi K, Okamoto S, Okamoto K, Ishida Y, Koike M, Watanabe M, Isa T, Hioki H. Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum. Neurosci Res 2022 PubMed ID: 36574563 DOI: 10.1016/j.neures.2022.11.008

17361 Hirose Y, Shindo N, Mori M, Onitsuka S, Isogai H, Hamada R, Hiramoto T, Ochi J, Takahashi D, Ueda T, Caaveiro JMM, Yoshida Y, Ohdo S, Matsunaga N, Toba S, Sasaki M, Orba Y, Sawa H, Sato A, Kawanishi E, Ojida A. Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease J Med Chem 2022 65(20):13852-13865 PubMed ID: 36229406 DOI: 10.1021/acs.jmedchem.2c01081

21141 Suenaga T, Mori Y, Suzutani T, Arase H. Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. Biochem Biophys Res Commun 2022 607:67-72 PubMed ID: 35367830 DOI: 10.1016/j.bbrc.2022.03.060

17694 Furuta T, Yamauchi K, Okamoto S, Takahashi M, Kakuta S, Ishida Y, Takenaka A, Yoshida A, Uchiyama Y, Koike M, Isa K, Isa T, Hioki H. Multi-scale light microscopy/electron microscopy neuronal imaging from brain to synapse with a tissue clearing method, Sca l eSF iScience 2021 25(1):103601 PubMed ID: 35106459 DOI: 10.1016/j.isci.2021.103601

12798 Johmura Y, Yamanaka T, Omori S, Wang TW, Sugiura Y, Matsumoto M, Suzuki N, Kumamoto S, Yamaguchi K, Hatakeyama S, Takami T, Yamaguchi R, Shimizu E, Ikeda K, Okahashi N, Mikawa R, Suematsu M, Arita M, Sugimoto M, Nakayama KI, Furukawa Y, Imoto S, Nakanishi M. Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders Science 2021 371(6526):265-270 PubMed ID: 33446552 DOI: 10.1126/science.abb5916

13320 Matsumoto N, Sekiya M, Fujimoto Y, Haga S, Sun-Wada GH, Wada Y, Nakanishi-Matsui M. Functional complementation of V-ATPase a subunit isoforms in osteoclasts. J Biochem 2021 169(4):459-466 PubMed ID: 33135054 DOI: 10.1093/jb/mvaa118

13345 Daifu T, Mikami M, Hiramatsu H, Iwai A, Umeda K, Noura M, Kubota H, Masuda T, Furuichi K, Takasaki S, Noguchi Y, Morita K, Bando T, Hirata M, Kataoka TR, Nakahata T, Kuwahara Y, Iehara T, Hosoi H, Takita J, Sugiyama H, Adachi S, Kamikubo Y. Suppression of malignant rhabdoid tumors through Chb-M'-mediated RUNX1 inhibition. Pediatr Blood Cancer 2021 PubMed ID: 33180377 DOI: 10.1002/pbc.28789

13351 Matsumoto Y, Kishida K, Matsumoto M, Matsuoka S, Kohyama M, Suenaga T, Arase H. A TCR-like antibody against a proinsulin-containing fusion peptide ameliorates type 1 diabetes in NOD mice. Biochem Biophys Res Commun 2021 PubMed ID: 33208230 DOI: 10.1016/j.bbrc.2020.11.019

13463 Shota Someya et al Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells iScienc 2021 24 PubMed ID: 33615198 DOI: 10.1016/j.isci.2021.102090

20008 Umaba R, Kitanishi T, Mizuseki K. Monosynaptic connection from the subiculum to medial mammillary nucleus neurons projecting to the anterior thalamus and Gudden's ventral tegmental nucleus. Neurosci Res 2021 PubMed ID: 33476683 DOI: 10.1016/j.neures.2021.01.006

20053 Takafuji S, Mori T, Nishimura N, Yamamoto N, Uemura S, Nozu K, Terui K, Toki T, Ito E, Muramatsu H, Takahashi Y, Matsuo M, Yamamura T, Iijima K. Usefulness of functional splicing analysis to confirm precise disease pathogenesis in Diamond-Blackfan anemia caused by intronic variants in RPS19. Pediatr Hematol Oncol 2021 1-16 PubMed ID: 33622161 DOI: 10.1080/08880018.2021.1887984

20060 Nishiike Y, Miyazoe D, Togawa R, Yokoyama K, Nakasone K, Miyata M, Kikuchi Y, Kamei Y, Todo T, Ishikawa-Fujiwara T, Ohno K, Usami T, Nagahama Y, Okubo K. Estrogen receptor 2b is the major determinant of sex-typical mating behavior and sexual preference in medaka. Curr Biol 2021 PubMed ID: 33639108 DOI: 10.1016/j.cub.2021.01.089

13513 Takahashi Y, Wake H, Sakaguchi M, Yoshii Y, Teshigawara K, Wang D, Nishibori M. Histidine-Rich Glycoprotein Stimulates Human Neutrophil Phagocytosis and Prolongs Survival through CLEC1A J Immunol 2021 206(4):737-750 PubMed ID: 33452125 DOI: 10.4049/jimmunol.2000817

20067 Aizawa N, Fujimori Y, Nakanishi O, Hayashi T, Goi Y, Kobayashi JI, Fujita T. Efficacy of the combination of KPR-5714, a novel transient receptor potential melastatin 8 (TRPM8) antagonist, and β3-adrenoceptor agonist or anticholinergic agent on bladder dysfunction in rats with bladder overactivity. Eur J Pharmacol 2021 173995 PubMed ID: 33675781 DOI: 10.1016/j.ejphar.2021.173995

20068 Nakamura R, Oyama T, Inokuchi M, Ishikawa S, Hirata M, Kawashima H, Ikeda H, Dobashi Y, Ooi A. Neural EGFL like 2 expressed in myoepithelial cells and suppressed breast cancer cell migration. Pathol Int 2021 PubMed ID: 33657249 DOI: 10.1111/pin.13087

13640 Fujita K, Koide N, Somiya M, Kuroda S, Hinuma S. A regulatory role of scavenger receptor class B type 1 in endocytosis and lipid droplet formation induced by liposomes containing phosphatidylethanolamine in HEK293T cells Biochim Biophys Acta Mol Cell Res 2021 1868(1):118859 PubMed ID: 32956759 DOI: 10.1016/j.bbamcr.2020.118859

20083 Hama K, Fujiwara Y, Hayama T, Ozawa T, Nozawa K, Matsuda K, Hashiguchi Y, Yokoyama K. Very long-chain fatty acids are accumulated in triacylglycerol and nonesterified forms in colorectal cancer tissues. Sci Rep 2021 11(1):6163 PubMed ID: 33731797 DOI: 10.1038/s41598-021-85603-w

20103 McKee HK, Kajiwara C, Yamaguchi T, Ishii Y, Shimizu N, Ohara A, Tateda K. Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-α via Toll-like receptors in macrophages. J Med Microbiol 2021 70(4) PubMed ID: 33830910 DOI: 10.1099/jmm.0.001342

13898 Takuma Kitanishi, Ryoko Umaba, Kenji Mizuseki Robust information routing by dorsal subiculum neurons Sci Adv 2021 7(11):eabf1913 PubMed ID: 33692111 DOI: 10.1126/sciadv.abf1913

13913 Rai D, Akagi T, Shimohata A, Ishii T, Gangi M, Maruyama T, Wada-Kiyama Y, Ogiwara I, Kaneda M. Involvement of the C-terminal domain in cell surface localization and G-protein coupling of mGluR6 J Neurochem 2021 158(4):837-848 PubMed ID: 33067823 DOI: 10.1111/jnc.15217

20114 Ojiro I, Nishio H, Yamazaki-Ito T, Nakano S, Ito S, Toyohara Y, Hiramoto T, Terada Y, Ito K. Trp-Trp acts as a multi-functional blocker for human bitter taste receptors, hTAS2R14, hTAS2R16, hTAS2R43, and hTAS2R46. Biosci Biotechnol Biochem 2021 PubMed ID: 33844825 DOI: 10.1093/bbb/zbab061

20138 Nagumo Y, Kandori S, Tanuma K, Nitta S, Chihara I, Shiga M, Hoshi A, Negoro H, Kojima T, Mathis BJ, Funakoshi Y, Nishiyama H. PLD1 promotes tumor invasion by regulation of MMP-13 expression via NF-κB signaling in bladder cancer. Cancer Lett 2021 511:15-25 PubMed ID: 33945837 DOI: 10.1016/j.canlet.2021.04.014

20147 Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol 2021 4(1):490 PubMed ID: 33883697 DOI: 10.1038/s42003-021-02003-6

14182 Somiya M, Kuroda S. Real-Time Luminescence Assay for Cytoplasmic Cargo Delivery of Extracellular Vesicles Anal Chem 2021 93(13):5612-5620 PubMed ID: 33759512 DOI: 10.1021/acs.analchem.1c00339

20150 Takeshita M, Suzuki K, Nakazawa M, Kamata H, Ishii M, Oyamada Y, Oshima H, Takeuchi T. Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease. J Autoimmun 2021 121:102661 PubMed ID: 34034155 DOI: 10.1016/j.jaut.2021.102661

20155 Sahoo PR, Kowada T, Mizukami S. Long-Term Mg2+ Imaging in Live Cells with a Targetable Fluorescent Probe. Methods Mol Biol 2021 2274:237-243 PubMed ID: 34050476 DOI: 10.1007/978-1-0716-1258-3_20

20157 Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat Commun 2021 12(1):3101 PubMed ID: 34035300 DOI: 10.1038/s41467-021-23452-x

20158 Osakabe K, Wada N, Murakami E, Miyashita N, Osakabe Y. Genome editing in mammalian cells using the CRISPR type I-D nuclease. Nucleic Acids Res 2021 PubMed ID: 34076237 DOI: 10.1093/nar/gkab348

20165 Kobayashi JI, Hirasawa H, Fujimori Y, Nakanishi O, Kamada N, Ikeda T, Yamamoto A, Kanbe H. Identification of N-acyl-N-indanyl-α-phenylglycinamides as selective TRPM8 antagonists designed to mitigate the risk of adverse effects. Bioorg Med Chem 2021 30:115903 PubMed ID: 33333445 DOI: 10.1016/j.bmc.2020.115903

14478 Yamanaka D, Shoda M, Matsubara T, Ishibashi KI, Motoi A, Motoi R, Motoi M, Ohno N, Adachi Y. Open-Label Study of the Influence of Food Containing the Royal Sun Mushroom, Agaricus brasiliensis KA21 (Agaricomycetes), on β-Glucan-Specific Antibody Production in Healthy Human Volunteers Int J Med Mushrooms 2021 23(2):13-28 PubMed ID: 33639078 DOI: 10.1615/IntJMedMushrooms.2020037471

20199 Tomita T, Kato M, Mishima T, Matsunaga Y, Sanjo H, Ito KI, Minagawa K, Matsui T, Oikawa H, Takahashi S, Takao T, Iwai N, Mino T, Takeuchi O, Maru Y, Hiratsuka S. Extracellular mRNA transported to the nucleus exerts translation-independent function. Nat Commun 2021 12(1):3655 PubMed ID: 34135341 DOI: 10.1038/s41467-021-23969-1

20200 Kuwabara S, Tanimoto Y, Okutani M, Jie M, Haseda Y, Kinugasa-Katayama Y, Aoshi T. Microfluidics sorting enables the isolation of an intact cellular pair complex of CD8+ T cells and antigen-presenting cells in a cognate antigen recognition-dependent manner. PLoS One 2021 16(6):e0252666 PubMed ID: 34125844 DOI: 10.1371/journal.pone.0252666

20216 Niinae T, Imami K, Sugiyama N, Ishihama Y. Identification of Endogenous Kinase Substrates by Proximity Labeling Combined with Kinase Perturbation and Phosphorylation Motifs. Mol Cell Proteomics 2021 100119 PubMed ID: 34186244 DOI: 10.1016/j.mcpro.2021.100119

14782 Uemura K, Sasaki M, Sanaki T, Toba S, Takahashi Y, Orba Y, Hall WW, Maenaka K, Sawa H, Sato A. MRC5 cells engineered to express ACE2 serve as a model system for the discovery of antivirals targeting SARS-CoV-2 Sci Rep 2021 11(1):5376 PubMed ID: 33686154 DOI: 10.1038/s41598-021-84882-7

14827 iu Y, Soh WT, Kishikawa JI, Hirose M, Nakayama EE, Li S, Sasai M, Suzuki T, Tada A, Arakawa A, Matsuoka S, Akamatsu K, Matsuda M, Ono C, Torii S, Kishida K, Jin H, Nakai W, Arase N, Nakagawa A, Matsumoto M, Nakazaki Y, Shindo Y, Kohyama M, Tomii K, Ohmura K, Ohshima S, Okamoto T, Yamamoto M, Nakagami H, Matsuura Y, Nakagawa A, Kato T, Okada M, Standley DM, Shioda T, Arase H. An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies Cell 2021 184(13):3452-3466.e18 PubMed ID: 34139176 DOI: 10.1016/j.cell.2021.05.032

20233 Koshizuka T, Kondo H, Kato H, Takahashi K. Human cytomegalovirus UL42 protein inhibits the degradation of glycoprotein B through inhibition of Nedd4 family ubiquitin E3 ligases. Microbiol Immunol 2021 PubMed ID: 34260096 DOI: 10.1111/1348-0421.12932

20240 Kaku T, Sugiura K, Entani T, Osabe K, Nagai T. Enhanced brightness of bacterial luciferase by bioluminescence resonance energy transfer. Sci Rep 2021 11(1):14994 PubMed ID: 34294849 DOI: 10.1038/s41598-021-94551-4

14939 Shuji Hinuma, Kazuyo Fujita, Shun’ichi Kuroda Binding of Nanoparticles Harboring Recombinant Large Surface Protein of Hepatitis B Virus to Scavenger Receptor Class B Type 1 Viruses 2021 13:1334 PubMed ID: 34372540 DOI: 10.3390/v13071334

20244 Yoshioka K, Obara K, Oikawa S, Uemura K, Yamaguchi A, Fujisawa K, Hanazawa H, Fujiwara M, Endoh T, Suzuki T, Regadera MD, Ito D, Ou G, Xu K, Tanaka Y. Docosahexaenoic acid inhibits U46619- and prostaglandin F2α-induced pig coronary and basilar artery contractions by inhibiting prostanoid TP receptors. Eur J Pharmacol 2021 174371 PubMed ID: 34329614 DOI: 10.1016/j.ejphar.2021.174371

20272 Ma Y, Yoshida T, Matoba K, Kida K, Shintani R, Piao Y, Jin J, Nishino T, Hanayama R. Identification of small compounds regulating the secretion of extracellular vesicles via a TIM4-affinity ELISA. Sci Rep 2021 11(1):13471 PubMed ID: 34188113 DOI: 10.1038/s41598-021-92860-2

15168 Hangai S, Kawamura T, Kimura Y, Chang CY, Hibino S, Yamamoto D, Nakai Y, Tateishi R, Oshima M, Oshima H, Kodama T, Moriya K, Koike K, Yanai H, Taniguchi T. Orchestration of myeloid-derived suppressor cells in the tumor microenvironment by ubiquitous cellular protein TCTP released by tumor cells Nat Immunol 2021 22(8):947-957 PubMed ID: 34239121 DOI: 10.1038/s41590-021-00967-5

20282 Nakanishi E, Uemura N, Akiyama H, Kinoshita M, Masanori S, Taruno Y, Yamakado H, Matsuzawa SI, Takeda S, Hirabayashi Y, Takahashi R. Impact of Gba2 on neuronopathic Gaucher's disease and α-synuclein accumulation in medaka (Oryzias latipes). Mol Brain 2021 14(1):80 PubMed ID: 33971917 DOI: 10.1186/s13041-021-00790-x

20283 Sakoguchi A, Saito F, Hirayasu K, Shida K, Matsuoka S, Itagaki S, Nakai W, Kohyama M, Suenaga T, Iwanaga S, Horii T, Arase H. Plasmodium falciparum RIFIN is a novel ligand for inhibitory immune receptor LILRB2. Biochem Biophys Res Commun 2021 548:167-173 PubMed ID: 33647792 DOI: 10.1016/j.bbrc.2021.02.033

20298 Nagano C, Takaoka Y, Kamei K, Hamada R, Ichikawa D, Tanaka K, Aoto Y, Ishiko S, Rossanti R, Sakakibara N, Okada E, Horinouchi T, Yamamura T, Tsuji Y, Noguchi Y, Ishimori S, Nagase H, Ninchoji T, Iijima K, Nozu K. Genotype-Phenotype Correlation in WT1 Exon 8 to 9 Missense Variants. Kidney Int Rep 2021 6(8):2114-2121 PubMed ID: 34386660 DOI: 10.1016/j.ekir.2021.05.009

20322 Fujisawa S, Qiu H, Nozaki S, Chiba S, Katoh Y, Nakayama K. ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane. Biol Open 2021 PubMed ID: 34447983 DOI: 10.1242/bio.058843

15284 Yoshiko Iizuka, Kinuko Inomata, Risako Nohara, Akimitsu Miyawaki and Yoshifumi Watanabe Activation of intracellular antioxidant master gene Nrf2 by the extracts of Garcinia subelliptica, Ocimum gratissimum L., and Plectranthus ornatus International Journal of Herbal Medicine 2021 9(3):54-60

15524 Fukasawa K, Kadota T, Horie T, Tokumura K, Terada R, Kitaguchi Y, Park G, Ochiai S, Iwahashi S, Okayama Y, Hiraiwa M, Yamada T, Iezaki T, Kaneda K, Yamamoto M, Kitao T, Shirahase H, Hazawa M, Wong RW, Todo T, Hirao A, Hinoi E. CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway Oncogene 2021 40(15):2803-2815 PubMed ID: 33727660 DOI: 10.1038/s41388-021-01745-1

20354 Noguchi T, Nakamura K, Satoda Y, Katoh Y, Nakayama K. CCRK/CDK20 regulates ciliary retrograde protein trafficking via interacting with BROMI/TBC1D32. PLoS One 2021 16(10):e0258497 PubMed ID: 34624068 DOI: 10.1371/journal.pone.0258497

20356 Yasumura M, Hagiwara A, Hida Y, Ohtsuka T. Planar cell polarity protein Vangl2 and its interacting protein Ap2m1 regulate dendritic branching in cortical neurons. Genes Cells 2021 PubMed ID: 34626136 DOI: 10.1111/gtc.12899

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20403 Yaguchi A, Oshikawa M, Watanabe G, Hiramatsu H, Uchida N, Hara C, Kaneko N, Sawamoto K, Muraoka T, Ajioka I. Efficient protein incorporation and release by a jigsaw-shaped self-assembling peptide hydrogel for injured brain regeneration. Nat Commun 2021 12(1):6623 PubMed ID: 34799548 DOI: 10.1038/s41467-021-26896-3

20440 Kanadome T, Hoshino N, Nagai T, Matsuda T, Yagi T. Development of FRET-based indicators for visualizing homophilic trans interaction of a clustered protocadherin. Sci Rep 2021 11(1):22237 PubMed ID: 34782670 DOI: 10.1038/s41598-021-01481-2

15879 Uemura K, Nobori H, Sato A, Sanaki T, Toba S, Sasaki M, Murai A, Saito-Tarashima N, Minakawa N, Orba Y, Kariwa H, Hall WW, Sawa H, Matsuda A, Maenaka K. 5-Hydroxymethyltubercidin exhibits potent antiviral activity against flaviviruses and coronaviruses, including SARS-CoV-2 iScience 2021 24(10):103120 PubMed ID: 34541466 DOI: 10.1016/j.isci.2021.103120

15898 Yafei Liu, Noriko Arase, Jun-ichi Kishikawa, Mika Hirose, Songling Li, Asa Tada, Sumiko Matsuoka, Akemi Arakawa, Kanako Akamatsu, Chikako Ono, Hui Jin, Kazuki Kishida, Wataru Nakai, Masako Kohyama, Atsushi Nakagawa, Yoshiaki Yamagishi, Hironori Nakagami, Atsushi Kumanogoh, Yoshiharu Matsuura, Daron M. Standley, Takayuki Kato, Masato Okada, Manabu Fujimoto, Hisashi Arase The SARS-CoV-2 Delta variant is poised to acquire complete resistance to wild-type spike vaccines bioRxiv 2021 DOI: 10.1101/2021.08.22.457114

20490 Ito F, Kato K, Yanatori I, Murohara T, Toyokuni S. Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin. Redox Biol 2021 47:102174 PubMed ID: 34700146 DOI: 10.1016/j.redox.2021.102174

20493 Ishida H, Murakami S, Kamiki H, Matsugo H, Katayama M, Sekine W, Ohira K, Takenaka-Uema A, Horimoto T. Construction of an Influenza D Virus with an Eight-Segmented Genome. Viruses 2021 13(11) PubMed ID: 34834971 DOI: 10.3390/v13112166

16115 Masuo K, Chen R, Yogo A, Sugiyama A, Fukuda A, Masui T, Uemoto S, Seno H, Takaishi S. SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2 Cancer Sci 2021 112(12):4987-4999 PubMed ID: 34628696 DOI: 10.1111/cas.15162

16241 Somiya M, Kuroda S. Reporter gene assay for membrane fusion of extracellular vesicles J Extracell Vesicles 2021 10(13):e12171 PubMed ID: 34807503 DOI: 10.1002/jev2.12171

16324 Sheng J, Kohno S, Okada N, Okahashi N, Teranishi K, Matsuda F, Shimizu H, Linn P, Nagatani N, Yamamura M, Harada K, Horike SI, Inoue H, Yano S, Kumar S, Kitajima S, Ajioka I, Takahashi C. Treatment of Retinoblastoma 1-Intact Hepatocellular Carcinoma With Cyclin-Dependent Kinase 4/6 Inhibitor Combination Therapy Hepatology 2021 74(4):1971-1993 PubMed ID: 33931882 DOI: 10.1002/hep.31872

16704 PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization PACAP-PAC1 Signaling Regulates Serotonin 2A Receptor Internalization Front Endocrinol (Lausanne) 2021 12:73245 PubMed ID: 34759890 DOI: 10.3389/fendo.2021.732456

16752 Ishii M, Ando J, Yamazaki S, Toyota T, Ohara K, Furukawa Y, Suehara Y, Nakanishi M, Nakashima K, Ohshima K, Nakauchi H, Ando M. iPSC-Derived Neoantigen-Specific CTL Therapy for Ewing Sarcoma Cancer Immunol Res 2021 9(10):1175-1186 PubMed ID: 34385178 DOI: 10.1158/2326-6066.CIR-21-0193

16759 Oda K, Matoba Y, Sugiyama M, Sakaguchi T. Structural Insight into the Interaction of Sendai Virus C Protein with Alix To Stimulate Viral Budding J Virol 2021 95(19):e0081521 PubMed ID: 34287046 DOI: 10.1128/JVI.00815-21

16762 Wang W, Zhu Y, Sun Z, Jin C, Wang X. Positive feedback regulation between USP15 and ERK2 inhibits osteoarthritis progression through TGF-β/SMAD2 signaling Arthritis Res Ther 2021 23(1):84 PubMed ID: 33726807 DOI: 10.1186/s13075-021-02456-4

16764 Pham Tuan Huy Nguyen Pham Quynh Anh Tong Thi Hang Nguyen Hoang Khue Tu Le Minh Thong Nguyen Van Thuan Yen Thi Hai Tran Home-made in vitro magnetic nanoparticle-based gene delivery system Science & Technology Development Journal 2021 24:2058-2065 DOI: 10.32508/stdj.v24i3.2573

16766 Ohn J, Been KW, Kim JY, Kim EJ, Park T, Yoon HJ, Ji JS, Okada-Iwabu M, Iwabu M, Yamauchi T, Kim YK, Seok C, Kwon O, Kim KH, Lee HH, Chung JH. Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth EMBO Mol Med 2021 13(10):e13790 PubMed ID: 34486824 DOI: 10.15252/emmm.202013790

21854 Gao P, Ma X, Yuan M, Yi Y, Liu G, Wen M, Jiang W, Ji R, Zhu L, Tang Z, Yu Q, Xu J, Yang R, Xia S, Yang M, Pan J, Yuan H, An H. E3 ligase Nedd4l promotes antiviral innate immunity by catalyzing K29-linked cysteine ubiquitination of TRAF3 Nat Commun 2021 12(1):1194 PubMed ID: 33608556 DOI: 10.1038/s41467-021-21456-1

17826 Matsubara D, Yoshimoto T, Soda M, Amano Y, Kihara A, Funaki T, Ito T, Sakuma Y, Shibano T, Endo S, Hagiwara K, Ishikawa S, Fukayama M, Murakami Y, Mano H, Niki T. Reciprocal expression of trefoil factor-1 and thyroid transcription factor-1 in lung adenocarcinomas Cancer Sci 2020 111(6):2183-2195 PubMed ID: 32237253 DOI: 10.1111/cas.14403

17935 Saito Y, Koya J, Araki M, Kogure Y, Shingaki S, Tabata M, McClure MB, Yoshifuji K, Matsumoto S, Isaka Y, Tanaka H, Kanai T, Miyano S, Shiraishi Y, Okuno Y, Kataoka K. Landscape and function of multiple mutations within individual oncogenes Nature 2020 582(7810):95-99 PubMed ID: 32494066 DOI: 10.1038/s41586-020-2175-2

11854 Yamamoto M, Terada Y, Motoyama T, Saito T, Ito K. Sweet proteins lysozyme and thaumatin are protein-type agonists for the calcium-sensing receptor. Biochem. Biophys. Res. Commun. 2020 521(1):227-231 PubMed ID: 31635806 DOI: 10.1016/j.bbrc.2019.10.111

6889 Iuchi K, Oya K, Hosoya K, Sasaki K, Sakurada Y, Nakano T, Hisatomi H. Different morphologies of human embryonic kidney 293T cells in various types of culture dishes. Cytotechnology 2020 72(1):131-140 PubMed ID: 31865498 DOI: 10.1007/s10616-019-00363-w

9863 Naomi Matsumoto, Reina Matsukawa, Shohei Takahashi, Koshi Kudo, Ge-Hong Sun-Wada, Yoh Wada, Mayumi Nakanishi-Matsui V-ATPase a3 Isoform Mutations Identified in Osteopetrosis Patients Abolish Its Expression and Disrupt Osteoclast Function Exp Cell Res 2020 389(2):111901 PubMed ID: 32045577 DOI: 10.1016/j.yexcr.2020.111901

9912 Hiroshi Suzuki, Yuichi Ozaki, Shigeho Ijiri, Koichiro Gen, Yukinori Kazeto 17β-Hydroxysteroid Dehydrogenase Type 12a Responsible for Testicular 11-ketotestosterone Synthesis in the Japanese Eel, Anguilla Japonica J Steroid Biochem Mol Biol 2020 198:105550 PubMed ID: 31778803 DOI: 10.1016/j.jsbmb.2019.105550

10370 Yusuke Higuchi, Jun-Ichirou Yasunaga, Yu Mitagami, Hirotake Tsukamoto, Kazutaka Nakashima, Koichi Ohshima, Masao Matsuoka HTLV-1 Induces T Cell Malignancy and Inflammation by Viral Antisense Factor-Mediated Modulation of the Cytokine Signaling Proc Natl Acad Sci U S A 2020 117(24):13740-13749 PubMed ID: 32471947 DOI: 10.1073/pnas.1922884117

11909 Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H. Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves. Ann. Thorac. Surg 2020 110(1):40-49 PubMed ID: 31760051 DOI: 10.1016/j.athoracsur.2019.09.085

11927 Yang J, Isaji T, Zhang G, Qi F, Duan C, Fukuda T, Gu J. EpCAM associates with integrin and regulates cell adhesion in cancer cells. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31806375 DOI: 10.1016/j.bbrc.2019.11.152

11944 Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, Gu J. ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins. FASEB J. 2020 PubMed ID: 31914669 DOI: 10.1096/fj.201901793R

11952 Kimura R, Yoshimaru T, Matsushita Y, Matsuo T, Ono M, Park JH, Sasa M, Miyoshi Y, Nakamura Y, Katagiri T. The GALNT6‑LGALS3BP axis promotes breast cancer cell growth. Int. J. Oncol. 2020 PubMed ID: 31894262 DOI: 10.3892/ijo.2019.4941

11958 Hou S, Hang Q, Isaji T, Fukuda T, Gu J. Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation. Biochem. Biophys. Res. Commun. 2020 PubMed ID: 31858971 DOI: 10.1016/j.bbrc.2019.11.188

11990 Duan C, Fukuda T, Isaji T, Qi F, Yang J, Wang Y, Takahashi S, Gu J. Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system. FASEB J. 2020 PubMed ID: 31908039 DOI: 10.1096/fj.201902313RR

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12028 Iuchi K, Tasaki Y, Shirai S, Hisatomi H. Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling. Biomed. Pharmacother. 2020 PubMed ID: 32004978 DOI: 10.1016/j.biopha.2020.109928

12086 Honda A, Chigwechokha PK, Takase R, Hayasaka O, Fujimura K, Kotani T, Komatsu M, Shiozaki K. Novel Nile tilapia Neu1 sialidases: Molecular cloning and biochemical characterization of the sialidases Neu1a and Neu1b. Gene 2020 PubMed ID: 32184168 DOI: 10.1016/j.gene.2020.144538

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12129 Mutai H, Wasano K, Momozawa Y, Kamatani Y, Miya F, Masuda S, Morimoto N, Nara K, Takahashi S, Tsunoda T, Homma K, Kubo M, Matsunaga T. Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans. PLoS Genet. 2020 PubMed ID: 32294086 DOI: 10.1371/journal.pgen.1008643

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13019 Matsuzaki M, Mandai M, Yamanari M, Totani K, Nishida M, Sugita S, Maeda T, Koide N, Takagi S, Hirami Y, Miyamoto N, Sugiyama S, Takahashi M, Kurimoto Y. Polarization-sensitive optical coherence tomography for estimating relative melanin content of autologous induced stem-cell derived retinal pigment epithelium. Sci Rep 2020 PubMed ID: 32376945 DOI: 10.1038/s41598-020-64601-4

13020 Koshizuka T, Inoue N. Activation of c-Jun by human cytomegalovirus UL42 through JNK activation. PLoS One 2020 PubMed ID: 32369499 DOI: 10.1371/journal.pone.0232635

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13044 Park M, Miyoshi C, Fujiyama T, Kakizaki M, Ikkyu A, Honda T, Choi J, Asano F, Mizuno S, Takahashi S, Yanagisawa M, Funato H. Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need. Sci Rep 2020 PubMed ID: 32457359 DOI: 10.1038/s41598-020-65647-0

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13212 Kitao T, Taguchi K, Seto S, Arasaki K, Ando H, Nagai H, Kubori T. Legionella Manipulates Non-canonical SNARE Pairing Using a Bacterial Deubiquitinase. Cell Rep 2020 PubMed ID: 32905772 DOI: 10.1016/j.celrep.2020.108107

13276 Arai Y, Kawashita N, Elgendy EM, Ibrahim MS, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y. PA Mutations Inherited during Viral Evolution Act Cooperatively To Increase Replication of Contemporary H5N1 Influenza Virus with an Expanded Host Range. J Virol 2020 PubMed ID: 33028722 DOI: 10.1128/JVI.01582-20

13293 Okamura M, Shizu R, Abe T, Kodama S, Hosaka T, Sasaki T, Yoshinari K. PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice. Cells 2020 PubMed ID: 33076328 DOI: 10.3390/cells9102296

13321 Kato M, Onoyama I, Kawakami M, Yoshida S, Kawamura K, Kodama K, Hori E, Cui L, Matsumura Y, Yagi H, Asanoma K, Yahata H, Itakura A, Takeda S, Kato K. Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia. PLoS One 2020 PubMed ID: 33141854 DOI: 10.1371/journal.pone.0241482

13327 Yamazaki T, Takahashi C, Taniguchi Y, Narukawa M, Misaka T, Ano Y. Bitter taste receptor activation by hop-derived bitter components induces gastrointestinal hormone production in enteroendocrine cells. Biochem Biophys Res Commun 2020 PubMed ID: 33160623 DOI: 10.1016/j.bbrc.2020.10.099

13330 Osakabe K, Wada N, Miyaji T, Murakami E, Marui K, Ueta R, Hashimoto R, Abe-Hara C, Kong B, Yano K, Osakabe Y. Genome editing in plants using CRISPR type I-D nuclease. Commun Biol 2020 3(1):648 PubMed ID: 33159140 DOI: 10.1038/s42003-020-01366-6

13490 Shoji S, Hanada K, Takahashi M, Watanabe K, Yonemochi M, Tomabechi Y, Shirouzu M. The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction FEBS Lett 2020 594(10):1532-1549 PubMed ID: 32017069 DOI: 10.1002/1873-3468.13752

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13570 Suzuki T, Morimoto N, Akaike A, Osakada F. Multiplex Neural Circuit Tracing With G-Deleted Rabies Viral Vectors Front Neural Circuits 2020 13:77 PubMed ID: 31998081 DOI: 10.3389/fncir.2019.00077

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14855 Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells Effective RNA Knockdown Using CRISPR-Cas13a and Molecular Targeting of the EML4-ALK Transcript in H3122 Lung Cancer Cells Int J Mol Sci 2020 21(23):8904 PubMed ID: 33255340 DOI: 10.3390/ijms21238904

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14868 Toda K, Tsukayama I, Nagasaki Y, Konoike Y, Tamenobu A, Ganeko N, Ito H, Kawakami Y, Takahashi Y, Miki Y, Yamamoto K, Murakami M, Suzuki-Yamamoto T. Red-kerneled rice proanthocyanidin inhibits arachidonate 5-lipoxygenase and decreases psoriasis-like skin inflammation Arch Biochem Biophys 2020 689:108307 PubMed ID: 32112739 DOI: 10.1016/j.abb.2020.108307

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11319 Nitta T, Kanoh H, Inamori KI, Suzuki A, Takahashi T, Inokuchi JI. Globo-series glycosphingolipids enhance Toll-like receptor 4-mediated inflammation and play a pathophysiological role in diabetic nephropathy. Glycobiology 2019 PubMed ID: 30476082 DOI: 10.1093/glycob/cwy105

11315 Arai Y, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y. Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals. J. Virol. 2019 PubMed ID: 30463961 DOI: 10.1128/JVI.01969-18

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11416 Matsumoto N, Nakanishi-Matsui M. Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30717974 DOI: 10.1016/j.bbrc.2019.01.118

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11475 Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H. Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30850159 DOI: 10.1016/j.bbrc.2019.02.120

11465 Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K. Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB. Sci Rep 2019 PubMed ID: 30837480 DOI: 10.1038/s41598-019-39424-7

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11621 Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y. PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals. PLoS Pathog. 2019 PubMed ID: 31265471 DOI: 10.1371/journal.ppat.1007919

11624 Furuse Y, Chaimongkol N, Okamoto M, Oshitani H. Evolutionary and Functional Diversity of the 5' Untranslated Region of Enterovirus D68: Increased Activity of the Internal Ribosome Entry Site of Viral Strains during the 2010s. Viruses 2019 PubMed ID: 31288421 DOI: 10.3390/v11070626

11643 Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H. Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7. Commun Biol 2019 PubMed ID: 31372509 DOI: 10.1038/s42003-019-0503-6

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11716 Makino Y, Jensen NH, Yokota N, Rossner MJ, Akiyama H, Shirahige K, Okada Y. Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression. Sci Rep 2019 PubMed ID: 30988352 DOI: 10.1038/s41598-019-42578-z

11720 Yamanashi T, Maki M, Kojima K, Shibukawa A, Tsukamoto T, Chowdhury S, Yamanaka A, Takagi S, Sudo Y. Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination. Sci Rep 2019 PubMed ID: 31133660 DOI: 10.1038/s41598-019-44308-x

11766 Su Y, Nichuguti N, Kuroki-Kami A, Fujiwara H. Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells. RNA 2019 PubMed ID: 31434792 DOI: 10.1261/rna.072512.119

11845 Kamiki H, Matsugo H, Ishida H, Kobayashi-Kitamura T, Sekine W, Takenaka-Uema A, Murakami S, Horimoto T. Adaptation of H3N2 canine influenza virus to feline cell culture. PLoS ONE 2019 PubMed ID: 31600274 DOI: 10.1371/journal.pone.0223507

11855 Morita A, Aoshima K, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T. High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines. Res. Vet. Sci. 2019 PubMed ID: 31648115 DOI: 10.1016/j.rvsc.2019.09.011

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11700 Uchibori R, Teruya T, Ido H, Ohmine K, Sehara Y, Urabe M, Mizukami H, Mineno J, Ozawa K. Functional Analysis of an Inducible Promoter Driven by Activation Signals from a Chimeric Antigen Receptor Mol Ther Oncolytics 2019 2:16-25 PubMed ID: 30662937 DOI: 10.1016/j.omto.2018.11.003

12285 Arisa Mitani, Takeshi Kobayashi, Yasuhito Hayashi, Natsuki Matsushita, Sachi Matsushita, Saori Nakao, Naoko Takahira, Atsushi Shiraishi, Yuichi Ohashi Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line PLoS One 2019 14(9):e0222454 PubMed ID: 31509592 DOI: 10.1371/journal.pone.0222454

12299 Nobuyoshi Tajima, Liu Xiaoyan, Makoto Taniguchi, Nobuo Kato 24S-hydroxycholesterol alters activity of large-conductance Ca 2+-dependent K + (slo1 BK) channel through intercalation into plasma membrane Biochim Biophys Acta Mol Cell Biol Lipids 2019 1864(10):1525-1535 PubMed ID: 31136842 DOI: 10.1016/j.bbalip.2019.05.010

12354 Shimizu K, Yamasaki S, Sakurai M, Yumoto N, Ikeda M, Mishima-Tsumagari C, Kukimoto-Niino M, Watanabe T, Kawamura M, Shirouzu M, Fujii SI. Granzyme A Stimulates pDCs to Promote Adaptive Immunity via Induction of Type I IFN Front Immunol 2019 10:1450 PubMed ID: 31293597 DOI: 10.3389/fimmu.2019.01450

12362 Takahashi Y, Takahashi H, Stern PL, Kirita T, Tsuboi A. Expression of Oncofetal Antigen 5T4 in Murine Taste Papillae Front Cell Neurosci 2019 13:343 PubMed ID: 31417363 DOI: 10.3389/fncel.2019.00343

12363 Ichikawa T, Nakahata S, Fujii M, Iha H, Shimoda K, Morishita K. The regulation of NDRG2 expression during ATLL development after HTLV-1 infection Biochim Biophys Acta Mol Basis Dis 2019 1865(10):2633-2646 PubMed ID: 31295529 DOI: 10.1016/j.bbadis.2019.07.001

12365 Okamura M, Shizu R, Hosaka T, Sasaki T, Yoshinari K. Possible involvement of the competition for the transcriptional coactivator glucocorticoid receptor-interacting protein 1 in the inflammatory signal-dependent suppression of PXR-mediated CYP3A induction in vitro Drug Metab Pharmacokinet 2019 34(4):272-279 PubMed ID: 31280915 DOI: 10.1016/j.dmpk.2019.04.005

12367 Mitsui Y, Tomonobu N, Watanabe M, Kinoshita R, Sumardika IW, Youyi C, Murata H, Yamamoto KI, Sadahira T, Rodrigo AGH, Takamatsu H, Araki K, Yamauchi A, Yamamura M, Fujiwara H, Inoue Y, Futami J, Saito K, Iioka H, Kondo E, Nishibori M, Toyooka S, Yamamoto Y, Nasu Y, Sakaguchi M. Upregulation of Mobility in Pancreatic Cancer Cells by Secreted S100A11 Through Activation of Surrounding Fibroblasts Oncol Res 2019 27(8):945-956. PubMed ID: 31046874 DOI: 10.3727/096504019X15555408784978

12437 Hara N, Osago H, Hiyoshi M, Kobayashi-Miura M, Tsuchiya M. Quantitative analysis of the effects of nicotinamide phosphoribosyltransferase induction on the rates of NAD+ synthesis and breakdown in mammalian cells using stable isotope-labeling combined with mass spectrometry PLoS One 2019 14(3):e0214000 PubMed ID: 30875389 DOI: 10.1371/journal.pone.0214000

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12588 Yoh T, Hatano E, Kasai Y, Fuji H, Nishi K, Toriguchi K, Sueoka H, Ohno M, Seo S, Iwaisako K, Taura K, Yamaguchi R, Kurokawa M, Fujimoto J, Kimura T, Uemoto S, Nishi E. Serum Nardilysin, a Surrogate Marker for Epithelial-Mesenchymal Transition, Predicts Prognosis of Intrahepatic Cholangiocarcinoma after Surgical Resection Clin Cancer Res 2019 25(2):619-628 PubMed ID: 30352908 DOI: 10.1158/1078-0432.CCR-18-0124

14890 Maishi N, Kikuchi H, Sato M, Nagao-Kitamoto H, Annan DA, Baba S, Hojo T, Yanagiya M, Ohba Y, Ishii G, Masutomi K, Shinohara N, Hida Y, Hida K. Development of Immortalized Human Tumor Endothelial Cells from Renal Cancer Int J Mol Sci 2019 20(18):4595 PubMed ID: 31533313 DOI: 10.3390/ijms20184595

17181 Sumardika IW, Chen Y, Tomonobu N, Kinoshita R, Ruma IMW, Sato H, Kondo E, Inoue Y, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Putranto EW, Hibino T, Nishibori M, Toyooka S, Sakaguchi M. Neuroplastin-β mediates S100A8/A9-induced lung cancer disseminative progression Mol Carcinog 2019 58(6):980-995 PubMed ID: 30720226 DOI: 10.1002/mc.22987

18202 Horigome E, Fujieda M, Handa T, Katayama A, Ito M, Ichihara A, Tanaka D, Gombodorj N, Yoshiyama S, Yamane A, Yamada K, Horiguchi J, Shinozuka K, Oyama T, Nishiyama M, Rokudai S. Mutant TP53 modulates metastasis of triple negative breast cancer through adenosine A2b receptor signaling Oncotarget 2018 9(77):34554-34566 PubMed ID: 30349649 DOI: 10.18632/oncotarget.26177

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10788 Koshizuka T, Kobayashi T, Ishioka K, Suzutani T. Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases. Sci Rep 2018 8:4447 PubMed ID: 29535361 DOI: 10.1038/s41598-018-22682-2

10808 Mochimaru Y, Negishi J, Murakami S, Musha S, Sato K, Okajima F, Tomura H. Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species. Zool. Sci. 2018 35:109-114 PubMed ID: 29623784 DOI: 10.2108/zs170145

10817 Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T. Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain. Development 2018 145: PubMed ID: 29661783 DOI: 10.1242/dev.159764

11042 Shigenori Inagaki; Masakazu Agetsuma; Takeharu Nagai A novel fiber-free technique for brain activity imaging in multiple freely behaving mice SPIE BiOS 2018 DOI: 10.1117/12.2302396

11080 Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Cherasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q. Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors. Nat Commun 2018 9(1):2041 PubMed ID: 29795268 DOI: 10.1038/s41467-018-04324-3

11137 Iuchi K, Morisada Y, Yoshino Y, Himuro T, Saito Y, Murakami T, Hisatomi H. Cold atmospheric-pressure nitrogen plasma induces the production of reactive nitrogen species and cell death by increasing intracellular calcium in HEK293T cells. Arch. Biochem. Biophys. 2018 654:136-145 PubMed ID: 30026027 DOI: 10.1016/j.abb.2018.07.015

11144 Funakohi-Tago M, Sakata T, Fujiwara S, Sakakura A, Sugai T, Tago K, Tamura H. Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells. Eur. J. Pharmacol. 2018 834:246-256 PubMed ID: 30053409 DOI: 10.1016/j.ejphar.2018.07.043

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11205 Shiozawa Y, Malcovati L, Galli A, Sato-Otsubo A, Kataoka K, Sato Y, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Makishima H, Shiraishi Y, Chiba K, Hellstrom-Lindberg E, Miyano S, Ogawa S, Cazzola M. Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia. Nat Commun 2018 PubMed ID: 30194306 DOI: 10.1038/s41467-018-06063-x

11222 Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K. UBL3 modification influences protein sorting to small extracellular vesicles. Nat Commun 2018 PubMed ID: 30258067 DOI: 10.1038/s41467-018-06197-y

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11112 Niino T, Tago K, Yasuda D, Takahashi K, Mashino T, Tamura H, Funakoshi-Tago M. A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis. Biochem. Pharmacol. 2018 155:182-197 PubMed ID: 29940171 DOI: 10.1016/j.bcp.2018.06.021

11217 Matsuura R, Kaji H, Tomioka A, Sato T, Narimatsu H, Moriwaki Y, Misawa H, Imai K, Tsuji S. Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1. Sci Rep 2018 PubMed ID: 30250045 DOI: 10.1038/s41598-018-32534-8

11313 Kamiki H, Matsugo H, Kobayashi T, Ishida H, Takenaka-Uema A, Murakami S, Horimoto T. A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice. Viruses 2018 PubMed ID: 30463209 DOI: 10.3390/v10110653

11343 Saeki E, Yasuhira S, Shibazaki M, Tada H, Doita M, Masuda T, Maesawa C. Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor. PLoS ONE 2018 PubMed ID: 30557316 DOI: 10.1371/journal.pone.0209296

11370 Xu P, Kai C, Kawasaki S, Kobayashi Y, Yamamoto K, Tsujikawa M, Hayashi R, Nishida K. A New in Vitro Model of GDLD by Knocking Out TACSTD2 and Its Paralogous Gene EpCAM in Human Corneal Epithelial Cells. Transl Vis Sci Technol 2018 PubMed ID: 30619650 DOI: 10.1167/tvst.7.6.30

4118 Kandori S, Kojima T, Matsuoka T, Yoshino T, Sugiyama A, Nakamura E, Shimazui T, Funakoshi Y, Kanaho Y, Nishiyama H. Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin. Cancer Sci. 2018 PubMed ID: 29660846 DOI: 10.1111/cas.13609

4119 Hirose Y, Onishi T, Miura S, Hatazawa Y, Kamei Y. Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells. J. Nutr. Sci. Vitaminol. 2018 PubMed ID: 29962435 DOI: 10.3177/jnsv.64.229

4120 Miyagawa Y, Matsushita Y, Suzuki H, Komatsu M, Yoshimaru T, Kimura R, Yanai A, Honda J, Tangoku A, Sasa M, Miyoshi Y, Katagiri T. Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer. Int. J. Oncol. 2018 PubMed ID: 29512727 DOI: 10.3892/ijo.2018.4301

4121 Kumeta M, Panina Y, Yamazaki H, Takeyasu K, Yoshimura SH. N-terminal dual lipidation-coupled molecular targeting into the primary cilium. Genes Cells 2018 PubMed ID: 29900630 DOI: 10.1111/gtc.12603

4122 Kato Y, Ninomiya K, Ohashi K, Tomida S, Makimoto G, Watanabe H, Kudo K, Matsumoto S, Umemura S, Goto K, Ichihara E, Ninomiya T, Kubo T, Sato A, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K. Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions. Cancer Sci. 2018 PubMed ID: 30053332 DOI: 10.1111/cas.13752

4279 Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, Fujihara-Iwata A, Hongo F, Okihara K, Ukimura O. CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells. Oncotarget 2018 PubMed ID: 29707137 DOI: 10.18632/oncotarget.24824

4465 Watanabe Y, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T. Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells. J. Virol. 2018 92(11) PubMed ID: 29563293 DOI: 10.1128/JVI.02004-17

4478 Omachi K, Kamura M, Teramoto K, Kojima H, Yokota T, Kaseda S, Kuwazuru J, Fukuda R, Koyama K, Matsuyama S, Motomura K, Shuto T, Suico MA, Kai H. A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome. Cell Chem Biol 2018 25(5):634-643.e4 PubMed ID: 29526710 DOI: 10.1016/j.chembiol.2018.02.003

9128 Asuka Yoshida, Ryoko Kawabata, Tomoyuki Honda, Kouji Sakai, Yasushi Ami, Takemasa Sakaguchi, Takashi Irie A Single Amino Acid Substitution Within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes J Virol 2018 92 (5) PubMed ID: 29237838 DOI: 10.1128/JVI.02094-17

14555 Iwai K, Yaguchi M, Nishimura K, Yamamoto Y, Tamura T, Nakata D, Dairiki R, Kawakita Y, Mizojiri R, Ito Y, Asano M, Maezaki H, Nakayama Y, Kaishima M, Hayashi K, Teratani M, Miyakawa S, Iwatani M, Miyamoto M, Klein MG, Lane W, Snell G, Tjhen R, He X, Pulukuri S, Nomura T. Anti-tumor efficacy of a novel CLK inhibitor via targeting RNA splicing and MYC-dependent vulnerability EMBO Mol Med 2018 10(6):e8289 PubMed ID: 29769258 DOI: 10.15252/emmm.201708289

14599 Senga S, Kawaguchi K, Kobayashi N, Ando A, Fujii H. A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells Oncotarget 2018 9(60):31753-31770 PubMed ID: 30167092 DOI: 10.18632/oncotarget.25878

14909 Iijima K, Kobayashi J, Ishizaka Y. Structural alteration of DNA induced by viral protein R of HIV-1 triggers the DNA damage response Retrovirology 2018 15(1):8 PubMed ID: 29338752 DOI: 10.1186/s12977-018-0391-8

15050 Kawabata Galbraith K, Fujishima K, Mizuno H, Lee SJ, Uemura T, Sakimura K, Mishina M, Watanabe N, Kengaku M. MTSS1 Regulation of Actin-Nucleating Formin DAAM1 in Dendritic Filopodia Determines Final Dendritic Configuration of Purkinje Cells Cell Rep 2018 24(1):95-106.e9 PubMed ID: 29972794 DOI: 10.1016/j.celrep.2018.06.013

15300 Matsumoto N, Sekiya M, Tohyama K, Ishiyama-Matsuura E, Sun-Wada GH, Wada Y, Futai M, Nakanishi-Matsui M. Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitmen Sci Rep 2018 ;8(1):6701 PubMed ID: 29712939 DOI: 10.1038/s41598-018-24918-7

7011 Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H. Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors. Nature 2017 552:101-105 PubMed ID: 29186116 DOI: 10.1038/nature24994

9875 Chung J, Aburaya S, Aoki W, Ueda M. Molecular changes in appearance of a cancer cell among normal HEK293T cells. J. Biosci. Bioeng. 2017 123:281-286 PubMed ID: 27777049 DOI: 10.1016/j.jbiosc.2016.09.012

10003 Takayama I, Tanabe H, Nishiyama T, Ito H, Amizuka N, Li M, Katsube KI, Kii I, Kudo A. Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice. J Cell Commun Signal 2017 11:5-13 PubMed ID: 28013443 DOI: 10.1007/s12079-016-0371-5

10065 Matsui T, Hori A, Hamako J, Matsushita F, Ozeki Y, Sakurai Y, Hayakawa M, Matsumoto M, Fujimura Y. Mutant botrocetin-2 inhibits von Willebrand factor-induced platelet agglutination. J. Thromb. Haemost. 2017 15:538-548 PubMed ID: 28071872 DOI: 10.1111/jth.13617

10081 Tsukamoto T, Chiba Y, Nakazaki A, Ishikawa Y, Nakane Y, Cho Y, Yotsu-Yamashita M, Nishikawa T, Wakamori M, Konoki K. Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B. Bioorg. Med. Chem. Lett. 2017 27:1247-1251 PubMed ID: 28143690 DOI: 10.1016/j.bmcl.2017.01.054

10100 Mori J, Tanikawa C, Ohnishi N, Funauchi Y, Toyoshima O, Ueda K, Matsuda K. EPSIN 3, A Novel p53 Target, Regulates the Apoptotic Pathway and Gastric Carcinogenesis. Neoplasia 2017 19:185-195 PubMed ID: 28152424 DOI: 10.1016/j.neo.2016.12.010

10115 Hang Q, Isaji T, Hou S, Wang Y, Fukuda T, Gu J. A Key Regulator of Cell Adhesion: Identification and Characterization of Important N-Glycosylation Sites on Integrin α5 for Cell Migration. Mol. Cell. Biol. 2017 37: PubMed ID: 28167607 DOI: 10.1128/MCB.00558-16

10136 Kawaguchi Y, Nariki H, Kawamoto N, Kanehiro Y, Miyazaki S, Suzuki M, Magari M, Tokumitsu H, Kanayama N. SRSF1-3 contributes to diversification of the immunoglobulin variable region gene by promoting accumulation of AID in the nucleus. Biochem. Biophys. Res. Commun. 2017 485:261-266 PubMed ID: 28235482 DOI: 10.1016/j.bbrc.2017.02.097

10163 Wada Y, Orba Y, Sasaki M, Kobayashi S, Carr MJ, Nobori H, Sato A, Hall WW, Sawa H. Discovery of a novel antiviral agent targeting the nonstructural protein 4 (nsP4) of chikungunya virus. Virology 2017 505:102-112 PubMed ID: 28236746 DOI: 10.1016/j.virol.2017.02.014

10164 Yamagata K, Kobayashi A. The cysteine-rich domain of TET2 binds preferentially to mono- and dimethylated histone H3K36. J. Biochem. 2017 161:327-330 PubMed ID: 28130413 DOI: 10.1093/jb/mvx004

10175 Tatebe H, Murayama S, Yonekura T, Hatano T, Richter D, Furuya T, Kataoka S, Furuita K, Kojima C, Shiozaki K. Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit. Elife 2017 6: PubMed ID: 28264193 DOI: 10.7554/eLife.19594

10218 Guo L, Elcioglu NH, Mizumoto S, Wang Z, Noyan B, Albayrak HM, Yamada S, Matsumoto N, Miyake N, Nishimura G, Ikegawa S. Identification of biallelic EXTL3 mutations in a novel type of spondylo-epi-metaphyseal dysplasia. J. Hum. Genet. 2017 62:797-801 PubMed ID: 28331220 DOI: 10.1038/jhg.2017.38

10232 Hashimoto H, Suda Y, Miyashita T, Ochiai A, Tsuboi M, Masutomi K, Kiyono T, Ishii G. A novel method to generate single-cell-derived cancer-associated fibroblast clones. J. Cancer Res. Clin. Oncol. 2017 143:1409-1419 PubMed ID: 28364361 DOI: 10.1007/s00432-017-2409-3

10235 Goyal S, Suzuki T, Li JR, Maeda S, Kishima M, Nishimura H, Shimizu Y, Suzuki H. RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions. BMC Mol. Biol. 2017 18:9 PubMed ID: 28376714 DOI: 10.1186/s12867-017-0087-y

10341 Hiwa R, Ohmura K, Arase N, Jin H, Hirayasu K, Kohyama M, Suenaga T, Saito F, Terao C, Atsumi T, Iwatani H, Mimori T, Arase H. Myeloperoxidase/HLA Class II Complexes Recognized by Autoantibodies in Microscopic Polyangiitis. Arthritis Rheumatol 2017 69:2069-2080 PubMed ID: 28575531 DOI: 10.1002/art.40170

10390 Takahashi Y, Tanikawa C, Miyamoto T, Hirata M, Wang G, Ueda K, Komatsu T, Matsuda K. Regulation of tubular recycling endosome biogenesis by the p53-MICALL1 pathway. Int. J. Oncol. 2017 51:724-736 PubMed ID: 28714518 DOI: 10.3892/ijo.2017.4060

10428 Ishii T, Homma K, Mano A, Akagi T, Shigematsu Y, Shimoda Y, Inoue H, Kakinuma Y, Kaneda M. Novel channel-mediated choline transport in cholinergic neurons of the mouse retina. J. Neurophysiol. 2017 118:1952-1961 PubMed ID: 28701543 DOI: 10.1152/jn.00506.2016

10456 Morita K, Maeda S, Suzuki K, Kiyose H, Taniguchi J, Liu PP, Sugiyama H, Adachi S, Kamikubo Y. Paradoxical enhancement of leukemogenesis in acute myeloid leukemia with moderately attenuated RUNX1 expressions. Blood Adv 2017 1:1440-1451 PubMed ID: 29296785 DOI: 10.1182/bloodadvances.2017007591

10541 Oda K, Oda T, Matoba Y, Sato M, Irie T, Sakaguchi T. Structural analysis of the STAT1:STAT2 heterodimer revealed the mechanism of Sendai virus C protein-mediated blockade of type 1 interferon signaling. J. Biol. Chem. 2017 292:19752-19766 PubMed ID: 28978648 DOI: 10.1074/jbc.M117.786285

10548 Hirano K, Namihira M. FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1. FEBS Open Bio 2017 7:1932-1942 PubMed ID: 29226080 DOI: 10.1002/2211-5463.12331

10637 Yamamura T, Nozu K, Miyoshi Y, Nakanishi K, Fujimura J, Horinouchi T, Minamikawa S, Mori N, Fujimaru R, Nakanishi K, Ninchoji T, Kaito H, Mariko TI, Morioka I, Matsuo M, Iijima K. An in vitro splicing assay reveals the pathogenicity of a novel intronic variant in ATP6V0A4 for autosomal recessive distal renal tubular acidosis. BMC Nephrol 2017 18:353 PubMed ID: 29202719 DOI: 10.1186/s12882-017-0774-4

10642 Suzuki T, Maeda S, Furuhata E, Shimizu Y, Nishimura H, Kishima M, Suzuki H. A screening system to identify transcription factors that induce binding site-directed DNA demethylation. Epigenetics Chromatin 2017 10:60 PubMed ID: 29221486 DOI: 10.1186/s13072-017-0169-6

4545 Shichita T, Ito M, Morita R, Komai K, Noguchi Y, Ooboshi H, Koshida R, Takahashi S, Kodama T, Yoshimura A. MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat. Med. 2017 23(6):723-732 PubMed ID: 28394332 DOI: 10.1038/nm.4312

4548 Meng H, Yamashita C, Shiba-Fukushima K, Inoshita T, Funayama M, Sato S, Hatta T, Natsume T, Umitsu M, Takagi J, Imai Y, Hattori N. Loss of Parkinson's disease-associated protein CHCHD2 affects mitochondrial crista structure and destabilizes cytochrome c. Nat Commun 2017 8:15500 PubMed ID: 28589937 DOI: 10.1038/ncomms15500

5434 Nagasato AI, Yamashita H, Matsuo M, Ueda K, Kioka N. The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix. Biosci Biotechnol Biochem 2017 81(6):1136-1147 PubMed ID: 28485208 DOI: 10.1080/09168451.2017.1289074

9498 Jaerin Sohn, Megumu Takahashi, Shinichiro Okamoto, Yoko Ishida, Takahiro Furuta, Hiroyuki Hioki A Single Vector Platform for High-Level Gene Transduction of Central Neurons: Adeno-Associated Virus Vector Equipped With the Tet-Off System PLoS One 2017 12(1):e0169611 PubMed ID: 28060929 DOI: 10.1371/journal.pone.0169611

12287 Shigenori Inagaki, Hidekazu Tsutsui, Kazushi Suzuki, Masakazu Agetsuma, Yoshiyuki Arai, Yuka Jinno, Guirong Bai, Matthew J Daniels, Yasushi Okamura, Tomoki Matsuda, Takeharu Nagai Genetically encoded bioluminescent voltage indicator for multi-purpose use in wide range of bioimaging Sci Rep 2017 7:42398 PubMed ID: 28205521 DOI: 10.1038/srep42398

13814 Nakano T, Kanai Y, Amano Y, Yoshimoto T, Matsubara D, Shibano T, Tamura T, Oguni S, Katashiba S, Ito T, Murakami Y, Fukayama M, Murakami T, Endo S, Niki T. Establishment of highly metastatic KRAS mutant lung cancer cell sublines in long-term three-dimensional low attachment cultures PLoS Onec 2017 12(8):e0181342 PubMed ID: 28786996 DOI: 10.1371/journal.pone.0181342

13978 Fujitani M, Zhang S, Fujiki R, Fujihara Y, Yamashita T. A chromosome 16p13.11 microduplication causes hyperactivity through dysregulation of miR-484/protocadherin-19 signaling Mol Psychiatry 2017 22(3):364-374 PubMed ID: 27378146 DOI: 10.1038/mp.2016.106

14236 Okumura N, Kitahara M, Okuda H, Hashimoto K, Ueda E, Nakahara M, Kinoshita S, Young RD, Quantock AJ, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Koizumi N. Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy Invest Ophthalmol Vis Sci 2017 58(9):3697-3707 PubMed ID: 28727885 DOI: 10.1167/iovs.16-21023

14257 Senga Y, Imamura H, Miyafusa T, Watanabe H, Honda S. AlphaScreen-based homogeneous assay using a pair of 25-residue artificial proteins for high-throughput analysis of non-native IgG Sci Rep 2017 7(1):12466 PubMed ID: 28963557 DOI: 10.1038/s41598-017-12693-w

14433 Endo H, Tanaka S, Imamura K, Adegawa S, Kikuta S, Sato R. Cry toxin specificities of insect ABCC transporters closely related to lepidopteran ABCC2 transporters Peptides 2017 98:86-92 PubMed ID: 28416297 DOI: 10.1016/j.peptides.2017.04.003

14594 Kano D, Nakagami Y, Kurihara H, Hosokawa S, Zenda S, Kusumoto M, Fujii H, Kaneta T, Saito S, Uesawa Y, Kagaya H. Development of a double-stranded siRNA labelling method by using 99m Tc and single photon emission computed tomography imaging J Drug Target 2017 25(2):172-178 PubMed ID: 27588821 DOI: 10.1080/1061186X.2016.1223675

14624 Tsukamoto T, Chiba Y, Wakamori M, Yamada T, Tsunogae S, Cho Y, Sakakibara R, Imazu T, Tokoro S, Satake Y, Adachi M, Nishikawa T, Yotsu-Yamashita M, Konoki K. Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na v 1.1 to Na v 1.7) Br J Pharmacol 2017 174(21):3881-3892 PubMed ID: 28832970 DOI: 10.1111/bph.13985

14704 Wu DC, Wang SSW, Liu CJ, Wuputra K, Kato K, Lee YL, Lin YC, Tsai MH, Ku CC, Lin WH, Wang SW, Kishikawa S, Noguchi M, Wu CC, Chen YT, Chai CY, Lin CS, Kuo KK, Yang YH, Miyoshi H, Nakamura Y, Saito S, Nagata K, Lin CS, Yokoyama KK. Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Stem Cells 2017 35(10):2115-2128 PubMed ID: 28782268 DOI: 10.1002/stem.2674

14749 Kikuta S, Watanabe SJ, Sato R, Gusev O, Nesmelov A, Sogame Y, Cornette R, Kikawada T. Towards water-free biobanks: long-term dry-preservation at room temperature of desiccation-sensitive enzyme luciferase in air-dried insect cells Sci Rep 2017 7(1):6540 PubMed ID: 28747745 DOI: 10.1038/s41598-017-06945-y

14759 Kobayashi JI, Hirasawa H, Ozawa T, Ozawa T, Takeda H, Fujimori Y, Nakanishi O, Kamada N, Ikeda T. Synthesis and optimization of novel α-phenylglycinamides as selective TRPM8 antagonists Bioorg Med Chem 2017 25(2):727-742 PubMed ID: 27964995 DOI: 10.1016/j.bmc.2016.11.049

14767 Elgendy EM, Arai Y, Kawashita N, Daidoji T, Takagi T, Ibrahim MS, Nakaya T, Watanabe Y. Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from pigeons J Gen Virol 2017 98(1):6-17 PubMed ID: 27926816 DOI: 10.1099/jgv.0.000674

14777 Shigenori Inagaki, Masakazu Agetsuma, Shinya Ohara, Toshio Iijima, Tetsuichi Wazawa, Yoshiyuki Arai, Takeharu Nagai In vivo brain activity imaging of interactively locomoting mice bioRxiv 2017 October 15, 2017 DOI: 10.1101/203422

16633 Khedgikar V, Abbruzzese G, Mathavan K, Szydlo H, Cousin H, Alfandari D. Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a Elife 2017 6:e26898 PubMed ID: 28829038 DOI: 10.7554/eLife.26898

7048 Suzuki K, Kimura T, Shinoda H, Bai G, Daniels MJ, Arai Y, Nakano M, Nagai T. Five colour variants of bright luminescent protein for real-time multicolour bioimaging. Nat Commun 2016 7:13718 PubMed ID: 27966527 DOI: 10.1038/ncomms13718

7056 Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature 2016 539:378-383 PubMed ID: 27806374 DOI: 10.1038/nature20142

7060 Kanda S, Yanagitani K, Yokota Y, Esaki Y, Kohno K. Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway. Proc. Natl. Acad. Sci. U.S.A. 2016 113:E5886-E5895 PubMed ID: 27651490 DOI: 10.1073/pnas.1604435113

7062 Hashimoto T, Horikawa DD, Saito Y, Kuwahara H, Kozuka-Hata H, Shin-I T, Minakuchi Y, Ohishi K, Motoyama A, Aizu T, Enomoto A, Kondo K, Tanaka S, Hara Y, Koshikawa S, Sagara H, Miura T, Yokobori S, Miyagawa K, Suzuki Y, Kubo T, Oyama M, Kohara Y, Fujiyama A, Arakawa K, Katayama T, Toyoda A, Kunieda T. Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein. Nat Commun 2016 7:12808 PubMed ID: 27649274 DOI: 10.1038/ncomms12808

7063 Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I. Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions. Nat. Biotechnol. 2016 34:1060-1065 PubMed ID: 27571369 DOI: 10.1038/nbt.3658

7069 Kataoka K, Shiraishi Y, Takeda Y, Sakata S, Matsumoto M, Nagano S, Maeda T, Nagata Y, Kitanaka A, Mizuno S, Tanaka H, Chiba K, Ito S, Watatani Y, Kakiuchi N, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Itonaga H, Imaizumi Y, Totoki Y, Munakata W, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Masuda K, Minato N, Kashiwase K, Izutsu K, Takaori-Kondo A, Miyazaki Y, Takahashi S, Shibata T, Kawamoto H, Akatsuka Y, Shimoda K, Takeuchi K, Seya T, Miyano S, Ogawa S. Aberrant PD-L1 expression through 3'-UTR disruption in multiple cancers. Nature 2016 534:402-6 PubMed ID: 27281199 DOI: 10.1038/nature18294

7133 Ichijo Y, Mochimaru Y, Azuma M, Satou K, Negishi J, Nakakura T, Oshima N, Mogi C, Sato K, Matsuda K, Okajima F, Tomura H. Two zebrafish G2A homologs activate multiple intracellular signaling pathways in acidic environment. Biochem. Biophys. Res. Commun. 2016 469:81-86 PubMed ID: 26614909 DOI: 10.1016/j.bbrc.2015.11.075

7262 Kikuta S, Hou BH, Sato R, Frommer WB, Kikawada T. FRET sensor-based quantification of intracellular trehalose in mammalian cells. Biosci. Biotechnol. Biochem. 2016 80:162-5 PubMed ID: 26214383 DOI: 10.1080/09168451.2015.1069699

9560 Hagiwara A, Ogiwara K, Takahashi T. Expression of Membrane Progestin Receptors (mPRs) in Granulosa Cells of Medaka Preovulatory Follicles. Zool. Sci. 2016 33:98-105 PubMed ID: 26853875 DOI: 10.2108/zs150093

9627 Koguchi T, Tanikawa C, Mori J, Kojima Y, Matsuda K. Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. Int. J. Oncol. 2016 48:2415-24 PubMed ID: 27035231 DOI: 10.3892/ijo.2016.3456

9649 Tsuchiya M, Niwa Y, Simizu S. N-glycosylation of R-spondin1 at Asn137 negatively regulates its secretion and Wnt/β-catenin signaling-enhancing activity. Oncol Lett 2016 11:3279-3286 PubMed ID: 27123103 DOI: 10.3892/ol.2016.4425

9664 Tanaka H, Fujiwara H, Ochi F, Tanimoto K, Casey N, Okamoto S, Mineno J, Kuzushima K, Shiku H, Sugiyama T, Barrett AJ, Yasukawa M. Development of Engineered T Cells Expressing a Chimeric CD16-CD3ζ Receptor to Improve the Clinical Efficacy of Mogamulizumab Therapy Against Adult T-Cell Leukemia. Clin. Cancer Res. 2016 22:4405-16 PubMed ID: 27091408 DOI: 10.1158/1078-0432.CCR-15-2714

9671 Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nakagawa I, Kubori T, Nagai H, Nakamaru Y, Katayama I, Colonna M, Arase H. Microbially cleaved immunoglobulins are sensed by the innate immune receptor LILRA2. Nat Microbiol 2016 1:16054 PubMed ID: 27572839 DOI: 10.1038/nmicrobiol.2016.54

9783 Khanom R, Nguyen CT, Kayamori K, Zhao X, Morita K, Miki Y, Katsube K, Yamaguchi A, Sakamoto K. Keratin 17 Is Induced in Oral Cancer and Facilitates Tumor Growth. PLoS ONE 2016 11:e0161163 PubMed ID: 27512993 DOI: 10.1371/journal.pone.0161163

9793 Yamaura K, Kiyonaka S, Numata T, Inoue R, Hamachi I. Discovery of allosteric modulators for GABAA receptors by ligand-directed chemistry. Nat. Chem. Biol. 2016 12:822-30 PubMed ID: 27526031 DOI: 10.1038/nchembio.2150

9807 Kobayashi T, Yagi Y, Nakamura T. Development of Genome Engineering Tools from Plant-Specific PPR Proteins Using Animal Cultured Cells. Methods Mol. Biol. 2016 1469:147-55 PubMed ID: 27557692 DOI: 10.1007/978-1-4939-4931-1_11

9843 Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H. Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ. Sci Rep 2016 6:29881 PubMed ID: 27431267 DOI: 10.1038/srep29881

9845 Hazawa M, Yasuda T, Saotome-Nakamura A, Tomiyama K, Obara C, Goto T, Tajima K. Intra- and extracellular plasminogen activator inhibitor-1 regulate effect of vitronectin against radiation-induced endothelial cell death. Vascul. Pharmacol. 2016 87:150-158 PubMed ID: 27650166 DOI: 10.1016/j.vph.2016.09.006

9846 Hang Q, Isaji T, Hou S, Zhou Y, Fukuda T, Gu J. N-Glycosylation of integrin α5 acts as a switch for EGFR-mediated complex formation of integrin α5β1 to α6β4. Sci Rep 2016 6:33507 PubMed ID: 27641064 DOI: 10.1038/srep33507

9908 Kurita K, Maeda M, Mansour MA, Kokuryo T, Uehara K, Yokoyama Y, Nagino M, Hamaguchi M, Senga T. TRIP13 is expressed in colorectal cancer and promotes cancer cell invasion. Oncol Lett 2016 12:5240-5246 PubMed ID: 28105232 DOI: 10.3892/ol.2016.5332

9916 Nishimura T, Ito S, Saito H, Hiver S, Shigetomi K, Ikenouchi J, Takeichi M. DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility. J. Cell Biol. 2016 215:559-573 PubMed ID: 27807130 DOI: 10.1083/jcb.201603107

10012 Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S. Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway. Sci Rep 2016 6:39557 PubMed ID: 28008968 DOI: 10.1038/srep39557

10015 Hirayama S, Hori Y, Benedek Z, Suzuki T, Kikuchi K. Fluorogenic probes reveal a role of GLUT4 N-glycosylation in intracellular trafficking. Nat. Chem. Biol. 2016 12:853-9 PubMed ID: 27547921 DOI: 10.1038/nchembio.2156

10016 Hou S, Hang Q, Isaji T, Lu J, Fukuda T, Gu J. Importance of membrane-proximal N-glycosylation on integrin β1 in its activation and complex formation. FASEB J. 2016 30:4120-4131 PubMed ID: 27565712 DOI: 10.1096/fj.201600665R

19247 Arai Y, Kawashita N, Daidoji T, Ibrahim MS, El-Gendy EM, Takagi T, Takahashi K, Suzuki Y, Ikuta K, Nakaya T, Shioda T, Watanabe Y. Novel Polymerase Gene Mutations for Human Adaptation in Clinical Isolates of Avian H5N1 Influenza Viruses PLoS Pathog 2016 12(4):e1005583 PubMed ID: 27097026 DOI: 10.1371/journal.ppat.1005583

12288 Kung-Kai Kuo, King-Teh Lee, Ker-Kong Chen, Ya-Han Yang, Ying-Chu Lin, Ming-Ho Tsai, Kenly Wuputra, Yen-Liang Lee, Chia-Chen Ku, Hiroyuki Miyoshi, Yukio Nakamura, Shigeo Saito, Chun-Chieh Wu, Chee-Yin Chai, Richard Eckner, Chen-Lung Steve Lin, Sophie S-W Wang, Deng-Chyang Wu, Chang-Shen Lin, Kazunari K Yokoyama Positive Feedback Loop of OCT4 and c-JUN Expedites Cancer Stemness in Liver Cancer Stem Cells 2016 34(11):2613-2624 PubMed ID: 27341307 DOI: 10.1002/stem.2447

12627 Elmansuri AZ, Tanino MA, Mahabir R, Wang L, Kimura T, Nishihara H, Kinoshita I, Dosaka-Akita H, Tsuda M, Tanaka S. Novel signaling collaboration between TGF-β and adaptor protein Crk facilitates EMT in human lung cancer Oncotarget 2016 7(19):27094-107 PubMed ID: 27027347 DOI: 10.18632/oncotarget.8314

12670 Mori J, Tanikawa C, Funauchi Y, Lo PH, Nakamura Y, Matsuda K. Cystatin C as a p53-inducible apoptotic mediator that regulates cathepsin L activity Cancer Sci 2016 107(3):298-306 PubMed ID: 26757339 DOI: 10.1111/cas.12881

12671 Lu J, Isaji T, Im S, Fukuda T, Kameyama A, Gu J. Expression of N-Acetylglucosaminyltransferase III Suppresses α2,3-Sialylation, and Its Distinctive Functions in Cell Migration Are Attributed to α2,6-Sialylation Levels J Biol Chem 2016 291(11):5708-20 PubMed ID: 26801611 DOI: 10.1074/jbc.M115.712836

12894 Sohn J, Okamoto S, Kataoka N, Kaneko T, Nakamura K, Hioki H. Differential Inputs to the Perisomatic and Distal-Dendritic Compartments of VIP-Positive Neurons in Layer 2/3 of the Mouse Barrel Cortex Front Neuroanat 2016 10:124 PubMed ID: 28066195 DOI: 10.3389/fnana.2016.00124

12923 Ryuzono S, Takase R, Oishi K, Ikeda A, Chigwechokha PK, Funahashi A, Komatsu M, Miyagi T, Shiozaki K. Lysosomal localization of Japanese medaka (Oryzias latipes) Neu1 sialidase and its highly conserved enzymatic profiles with human Gene 2016 575(2 Pt 2):513-523. PubMed ID: 26432003 DOI: 10.1016/j.gene.2015.09.028

12933 Obayashi M, Yoshida M, Tsunematsu T, Ogawa I, Sasahira T, Kuniyasu H, Imoto I, Abiko Y, Xu D, Fukunaga S, Tahara H, Kudo Y, Nagao T, Takata T. microRNA-203 suppresses invasion and epithelial-mesenchymal transition induction via targeting NUAK1 in head and neck cancer Oncotarget 2016 7(7):8223-39 PubMed ID: 26882562 DOI: 10.18632/oncotarget.6972

12941 Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H, Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells Cancer Microenviron 2016 9(2-3):93-105 PubMed ID: 27334300 DOI: 10.1007/s12307-016-0185-2

13460 Miyake T, Kumasawa K, Sato N, Takiuchi T, Nakamura H, Kimura T. Soluble VEGF receptor 1 (sFLT1) induces non-apoptotic death in ovarian and colorectal cancer cells Sci Rep 2016 6:24853 PubMed ID: 27103202 DOI: 10.1038/srep24853

13471 Wang SS, Wuputra K, Liu CJ, Lin YC, Chen YT, Chai CY, Lin CS, Kuo KK, Tsai MH, Wang SW, Chen KK, Miyoshi H, Nakamura Y, Saito S, Hanafusa T, Wu DC, Lin CS, Yokoyama KK. Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer Oncotarget 2016 7(24):36049-36064 PubMed ID: 27144338 DOI: 10.18632/oncotarget.9102

14024 Yasuhira S, Shibazaki M, Nishiya M, Maesawa C. Paclitaxel-induced aberrant mitosis and mitotic slippage efficiently lead to proliferative death irrespective of canonical apoptosis and p53 Cell Cycle 2016 15(23):3268-3277 PubMed ID: 27764550 DOI: 10.1080/15384101.2016.1242537

14114 Sakamoto Y, Kanatsu J, Toh M, Naka A, Kondo K, Iida K. The Dietary Isoflavone Daidzein Reduces Expression of Pro-Inflammatory Genes through PPARα/γ and JNK Pathways in Adipocyte and Macrophage Co-Cultures PLoS One 2016 11(2):e0149676 PubMed ID: 26901838 DOI: 10.1371/journal.pone.0149676

14151 Hou S, Isaji T, Hang Q, Im S, Fukuda T, Gu J. Distinct effects of β1 integrin on cell proliferation and cellular signaling in MDA-MB-231 breast cancer cells Sci Rep 2016 6:18430 PubMed ID: 26728650 DOI: 10.1038/srep18430

14157 Sakuma T, Nakade S, Sakane Y, Suzuki KT, Yamamoto T. MMEJ-assisted gene knock-in using TALENs and CRISPR-Cas9 with the PITCh systems Nat Protoc 2016 11(1):118-33 PubMed ID: 26678082 DOI: 10.1038/nprot.2015.140

14158 Johmura Y, Sun J, Kitagawa K, Nakanishi K, Kuno T, Naiki-Ito A, Sawada Y, Miyamoto T, Okabe A, Aburatani H, Li S, Miyoshi I, Takahashi S, Kitagawa M, Nakanishi M. SCF(Fbxo22)-KDM4A targets methylated p53 for degradation and regulates senescence Nat Commun 2016 7:10574 PubMed ID: 26868148 DOI: 10.1038/ncomms10574

14168 Kikuta S, Endo H, Tomita N, Takada T, Morita C, Asaoka K, Sato R. Characterization of a ligand-gated cation channel based on an inositol receptor in the silkworm, Bombyx mori Insect Biochem Mol Biol 2016 74:12-20 PubMed ID: 27132146 DOI: 10.1016/j.ibmb.2016.04.010

14176 Tetsuo Koshizuka, Keiichiro Tanaka, Tatsuo Suzutani Degradation of host ubiquitin E3 ligase Itch by human cytomegalovirus UL42 Journal of General Virology 2016 97:196-208 PubMed ID: 26555021 DOI: 10.1099/jgv.0.000336

14950 Mang D, Shu M, Endo H, Yoshizawa Y, Nagata S, Kikuta S, Sato R. Expression of a sugar clade gustatory receptor, BmGr6, in the oral sensory organs, midgut, and central nervous system of larvae of the silkworm Bombyx mori Insect Biochem Mol Biol 2016 70:85-98 PubMed ID: 26721200 DOI: 10.1016/j.ibmb.2015.12.008

7180 Hang Q, Isaji T, Hou S, Im S, Fukuda T, Gu J. Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation. J. Biol. Chem. 2015 290:29345-60 PubMed ID: 26483551 DOI: 10.1074/jbc.M115.682229

7190 Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S. Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat. Genet. 2015 47:1304-15 PubMed ID: 26437031 DOI: 10.1038/ng.3415

7216 Aoki N, Yamaguchi S, Kitajima T, Takehara A, Katagiri-Nakagawa S, Matsui R, Watanabe D, Matsushima T, Homma KJ. Critical role of the neural pathway from the intermediate medial mesopallium to the intermediate hyperpallium apicale in filial imprinting of domestic chicks (Gallus gallus domesticus). Neuroscience 2015 308:115-24 PubMed ID: 26362886 DOI: 10.1016/j.neuroscience.2015.09.014

7242 Okumura N, Minamiyama R, Ho LT, Kay EP, Kawasaki S, Tourtas T, Schlotzer-Schrehardt U, Kruse FE, Young RD, Quantock AJ, Kinoshita S, Koizumi N. Involvement of ZEB1 and Snail1 in excessive production of extracellular matrix in Fuchs endothelial corneal dystrophy. Lab. Invest. 2015 95:1291-304 PubMed ID: 26302187 DOI: 10.1038/labinvest.2015.111

7252 Ichikawa T, Nakahata S, Fujii M, Iha H, Morishita K. Loss of NDRG2 enhanced activation of the NF-κB pathway by PTEN and NIK phosphorylation for ATL and other cancer development. Sci Rep 2015 5:12841 PubMed ID: 26269411 DOI: 10.1038/srep12841

7263 Ichikawa T, Nakahata S, Tamura T, Manachai N, Morishita K. The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β. Cell. Signal. 2015 27:2087-98 PubMed ID: 26208882 DOI: 10.1016/j.cellsig.2015.07.012

7274 Tohmonda T, Yoda M, Iwawaki T, Matsumoto M, Nakamura M, Mikoshiba K, Toyama Y, Horiuchi K. IRE1α/XBP1-mediated branch of the unfolded protein response regulates osteoclastogenesis. J. Clin. Invest. 2015 125:3269-79 PubMed ID: 26193638 DOI: 10.1172/JCI76765

7371 Kimura T, Endo S, Inui M, Saitoh S, Miyake K, Takai T. Endoplasmic Protein Nogo-B (RTN4-B) Interacts with GRAMD4 and Regulates TLR9-Mediated Innate Immune Responses. J. Immunol. 2015 194:5426-36 PubMed ID: 25917084 DOI: 10.4049/jimmunol.1402006

7393 Ito T, Hioki H, Sohn J, Okamoto S, Kaneko T, Iino S, Oliver DL. Convergence of Lemniscal and Local Excitatory Inputs on Large GABAergic Tectothalamic Neurons. J. Comp. Neurol. 2015 523:2277-96 PubMed ID: 25879870 DOI: 10.1002/cne.23789

7426 Nakazato R, Takarada T, Ikeno S, Nakamura S, Kutsukake T, Hinoi E, Yoneda Y. Upregulation of Runt-Related Transcription Factor-2 Through CCAAT Enhancer Binding Protein-β Signaling Pathway in Microglial BV-2 Cells Exposed to ATP. J. Cell. Physiol. 2015 230:2510-21 PubMed ID: 25802132 DOI: 10.1002/jcp.24988

7435 Ebina H, Kanemura Y, Misawa N, Sakuma T, Kobayashi T, Yamamoto T, Koyanagi Y. A high excision potential of TALENs for integrated DNA of HIV-based lentiviral vector. PLoS ONE 2015 10:e0120047 PubMed ID: 25781496 DOI: 10.1371/journal.pone.0120047

7468 Masuda K, Chiyoda T, Sugiyama N, Segura-Cabrera A, Kabe Y, Ueki A, Banno K, Suematsu M, Aoki D, Ishihama Y, Saya H, Kuninaka S. LATS1 and LATS2 phosphorylate CDC26 to modulate assembly of the tetratricopeptide repeat subcomplex of APC/C. PLoS ONE 2015 10:e0118662 PubMed ID: 25723520 DOI: 10.1371/journal.pone.0118662

7514 Mochimaru Y, Azuma M, Oshima N, Ichijo Y, Satou K, Matsuda K, Asaoka Y, Nishina H, Nakakura T, Mogi C, Sato K, Okajima F, Tomura H. Extracellular acidification activates ovarian cancer G-protein-coupled receptor 1 and GPR4 homologs of zebra fish. Biochem. Biophys. Res. Commun. 2015 457:493-9 PubMed ID: 25576873 DOI: 10.1016/j.bbrc.2014.12.105

19257 Makino S, Zhulyn O, Mo R, Puviindran V, Zhang X, Murata T, Fukumura R, Ishitsuka Y, Kotaki H, Matsumaru D, Ishii S, Hui CC, Gondo Y. T396I mutation of mouse Sufu reduces the stability and activity of Gli3 repressor PLoS One 2015 10(3):e0119455 PubMed ID: 25760946 DOI: 10.1371/journal.pone.0119455

3744 Nakamura R, Oyama T, Tajiri R, Mizokami A, Namiki M, Nakamoto M, Ooi A. Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma. Cancer Sci 2015 106(5):656-64 PubMed ID: 25726761 DOI: 10.1111/cas.12649

9488 Tadahiro Suenaga, Maki Matsumoto, Fuminori Arisawa, Masako Kohyama, Kouyuki Hirayasu, Yasuko Mori, Hisashi Arase Sialic Acids on Varicella-Zoster Virus Glycoprotein B Are Required for Cell-Cell Fusion J Biol Chem 2015 290(32):19833-43 PubMed ID: 26105052 DOI: 10.1074/jbc.M114.635508

14284 Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, Duvvuri U, Gaither LA. ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer Oncotarget 2015 6(11):9173-88 PubMed ID: 25823819 DOI: 10.18632/oncotarget.3277

15063 Tanaka S, Tanaka J, Miwa Y, Horikawa DD, Katayama T, Arakawa K, Toyoda A, Kubo T, Kunieda T. Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic Tardigrade improve osmotic tolerance of human cells PLoS One 2015 10(2):e0118272 PubMed ID: 25675104 DOI: 10.1371/journal.pone.0118272

15189 Shinmyo Y, Asrafuzzaman Riyadh M, Ahmed G, Bin Naser I, Hossain M, Takebayashi H, Kawasaki H, Ohta K, Tanaka H. Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex Nat Commun 2015 6:10232 PubMed ID: 26659141 DOI: 10.1038/ncomms10232

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15222 Ohishi K, Toume K, Arai MA, Koyano T, Kowithayakorn T, Mizoguchi T, Itoh M, Ishibashi M. 9-Hydroxycanthin-6-one, a β-Carboline Alkaloid from Eurycoma longifolia, Is the First Wnt Signal Inhibitor through Activation of Glycogen Synthase Kinase 3β without Depending on Casein Kinase 1α J Nat Prod 2015 78(5):1139-46 PubMed ID: 25905468 DOI: 10.1021/acs.jnatprod.5b00153

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