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Cell No. : Cell Name
RCB2202 : 293T  update : 2020/09/01
CommentHuman cell line expressing SV40 large T antigen abundantly.
Comment from the depositor
Terms and conditionsCan be used only by not-for-profit entities and only for not-for-profit academic purposes.
Remarks
Order Form Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, Category I and II, depending on the sort of user institutions and the purposes of use.Please use an appropriate MTA(to see).In case of Restriction "a" or "f", please contact RIKEN BRC(cellbank.brc@riken.jp) regarding any kind of for-profit use.
Basic information Depositor Miyoshi, Hiroyuki
Year of deposit 2005
Original cell HEK293
Animal human < Mammals
Genus Homo
Species sapiens
Age at sampling embryo
Tissue kidney
Classification transformed
Lifespan infinite
Morphology epithelial-like
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives DMEM (low glucose) + 10% FBS (heat inactivated)
Antibiotics Free
Passage method 0.25% trypsin
Culture information Passage ratio 1 : 10 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
STR(human) OK
Animal PCR OK
Images
deposit info
lot info
Reference information Reference 4
User's Publication 158


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Reference
3489  DuBridge RB, Tang P, Hsia HC, Leong PM, Miller JH, Calos MP.  Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system.  Mol Cell Biol  1987  7(1):379-87  PubMed ID: 3031469
4972  Graham FL, Harrison T, Williams J.  Defective transforming capacity of adenovirus type 5 host-range mutants.  Virology  1978  86(1):10-21  PubMed ID: 664220
2415  Harrison T, Graham F, Williams J  Host-range mutants of adenovirus type 5 defective for growth in HeLa cells.  Virology  1977  77:319-29  PubMed ID: 841862
2414  Graham, F L, Smiley J, Russell, W C, Nairn R  Characteristics of a human cell line transformed by DNA from human adenovirus type 5.  J Gen Virol  1977  36:59-74  PubMed ID: 886304

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User's Publication
6889  Iuchi K, Oya K, Hosoya K, Sasaki K, Sakurada Y, Nakano T, Hisatomi H.  Different morphologies of human embryonic kidney 293T cells in various types of culture dishes.  Cytotechnology  2020  72(1):131-140  PubMed ID: 31865498
9912  Hiroshi Suzuki, Yuichi Ozaki, Shigeho Ijiri, Koichiro Gen, Yukinori Kazeto  17β-Hydroxysteroid Dehydrogenase Type 12a Responsible for Testicular 11-ketotestosterone Synthesis in the Japanese Eel, Anguilla Japonica  J Steroid Biochem Mol Biol  2020  198:105550  PubMed ID: 31778803
10370  Yusuke Higuchi, Jun-Ichirou Yasunaga, Yu Mitagami, Hirotake Tsukamoto, Kazutaka Nakashima, Koichi Ohshima, Masao Matsuoka  HTLV-1 Induces T Cell Malignancy and Inflammation by Viral Antisense Factor-Mediated Modulation of the Cytokine Signaling  Proc Natl Acad Sci U S A  2020  117(24):13740-13749  PubMed ID: 32471947
11927  Yang J, Isaji T, Zhang G, Qi F, Duan C, Fukuda T, Gu J.  EpCAM associates with integrin and regulates cell adhesion in cancer cells.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 31806375
11944  Qi F, Isaji T, Duan C, Yang J, Wang Y, Fukuda T, Gu J.  ST3GAL3, ST3GAL4, and ST3GAL6 differ in their regulation of biological functions via the specificities for the α2,3-sialylation of target proteins.  FASEB J.  2020    PubMed ID: 31914669
11952  Kimura R, Yoshimaru T, Matsushita Y, Matsuo T, Ono M, Park JH, Sasa M, Miyoshi Y, Nakamura Y, Katagiri T.  The GALNT6‑LGALS3BP axis promotes breast cancer cell growth.  Int. J. Oncol.  2020    PubMed ID: 31894262
11958  Hou S, Hang Q, Isaji T, Fukuda T, Gu J.  Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 31858971
11990  Duan C, Fukuda T, Isaji T, Qi F, Yang J, Wang Y, Takahashi S, Gu J.  Deficiency of core fucosylation activates cellular signaling dependent on FLT3 expression in a Ba/F3 cell system.  FASEB J.  2020    PubMed ID: 31908039
12005  Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K.  An ultra-stable cytoplasmic antibody engineered for in vivo applications.  Nat Commun  2020    PubMed ID: 31953402
12015  Yamamoto H, Kon T, Omori Y, Furukawa T.  Functional and Evolutionary Diversification of Otx2 and Crx in Vertebrate Retinal Photoreceptor and Bipolar Cell Development.  Cell Rep  2020    PubMed ID: 31968244
12027  Momoi Y, Nishikimi A, Du G, Kataoka T, Katagiri K.  Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 31996307
12028  Iuchi K, Tasaki Y, Shirai S, Hisatomi H.  Upregulation of nuclear factor (erythroid-derived 2)-like 2 protein level in the human colorectal adenocarcinoma cell line DLD-1 by a heterocyclic organobismuth(III) compound: Effect of organobismuth(III) compound on NRF2 signaling.  Biomed. Pharmacother.  2020    PubMed ID: 32004978
12086  Honda A, Chigwechokha PK, Takase R, Hayasaka O, Fujimura K, Kotani T, Komatsu M, Shiozaki K.  Novel Nile tilapia Neu1 sialidases: Molecular cloning and biochemical characterization of the sialidases Neu1a and Neu1b.  Gene  2020    PubMed ID: 32184168
12096  Funakoshi-Tago M, Yu S, Kushida A, Takeuchi K, Tamura H.  Kampo medicines, Rokumigan, Hachimijiogan, and Goshajinkigan, significantly inhibit glucagon-induced CREB activation.  Heliyon  2020    PubMed ID: 32215330
12129  Mutai H, Wasano K, Momozawa Y, Kamatani Y, Miya F, Masuda S, Morimoto N, Nara K, Takahashi S, Tsunoda T, Homma K, Kubo M, Matsunaga T.  Variants encoding a restricted carboxy-terminal domain of SLC12A2 cause hereditary hearing loss in humans.  PLoS Genet.  2020    PubMed ID: 32294086
11179  Ali F, Hossain MS, Sejimo S, Akashi K.  Plasmalogens Inhibit Endocytosis of Toll-like Receptor 4 to Attenuate the Inflammatory Signal in Microglial Cells.  Mol. Neurobiol.  2019  56(5):3404-3419  PubMed ID: 30128650
11244  Zhang G, Isaji T, Xu Z, Lu X, Fukuda T, Gu J.  N-acetylglucosaminyltransferase-I as a novel regulator of epithelial-mesenchymal transition.  FASEB J.  2019    PubMed ID: 30307765
11273  Mizuno M, Miki R, Moriyama Y, Ushida T, Imai K, Niimi K, Nakano T, Tsuda H, Sumigama S, Yamamoto E, Senga T, Iwase A, Kikkawa F, Kotani T.  The role of E2F8 in the human placenta.  Mol Med Rep  2019    PubMed ID: 30387815
11319  Nitta T, Kanoh H, Inamori KI, Suzuki A, Takahashi T, Inokuchi JI.  Globo-series glycosphingolipids enhance Toll-like receptor 4-mediated inflammation and play a pathophysiological role in diabetic nephropathy.  Glycobiology  2019    PubMed ID: 30476082
11315  Arai Y, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Suzuki Y, Nakaya T, Matsumoto K, Watanabe Y.  Genetic Compatibility of Reassortants between Avian H5N1 and H9N2 Influenza Viruses with Higher Pathogenicity in Mammals.  J. Virol.  2019    PubMed ID: 30463961
11355  Xu Z, Isaji T, Fukuda T, Wang Y, Gu J.  O-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes.  J. Biol. Chem.  2019    PubMed ID: 30587575
11368  Suzuki N, Hirano K, Ogino H, Ochi H.  Arid3a regulates nephric tubule regeneration via evolutionarily conserved regeneration signal-response enhancers.  Elife  2019    PubMed ID: 30616715
11404  Kataoka K, Miyoshi H, Sakata S, Dobashi A, Couronné L, Kogure Y, Sato Y, Nishida K, Gion Y, Shiraishi Y, Tanaka H, Chiba K, Watatani Y, Kakiuchi N, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Sanada M, Onozawa M, Teshima T, Yoshiki Y, Ishida T, Suzuki K, Shimada K, Tomita A, Kato M, Ota Y, Izutsu K, Demachi-Okamura A, Akatsuka Y, Miyano S, Yoshino T, Gaulard P, Hermine O, Takeuchi K, Ohshima K, Ogawa S.  Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas.  Leukemia  2019    PubMed ID: 30683910
11416  Matsumoto N, Nakanishi-Matsui M.  Proton pumping V-ATPase inhibitor bafilomycin A1 affects Rab7 lysosomal localization and abolishes anterograde trafficking of osteoclast secretory lysosomes.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30717974
11418  Shimizu Y, Kohyama M, Yorifuji H, Jin H, Arase N, Suenaga T, Arase H.  FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules.  Int. Immunol.  2019    PubMed ID: 30721990
11430  Ishibashi D, Homma T, Nakagaki T, Fuse T, Sano K, Satoh K, Mori T, Atarashi R, Nishida N.  Type I interferon protects neurons from prions in in vivo models.  Brain  2019    PubMed ID: 30753318
11475  Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H.  Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 30850159
11465  Sarkar B, Nishikata I, Nakahata S, Ichikawa T, Shiraga T, Saha HR, Fujii M, Tanaka Y, Shimoda K, Morishita K.  Degradation of p47 by autophagy contributes to CADM1 overexpression in ATLL cells through the activation of NF-κB.  Sci Rep  2019    PubMed ID: 30837480
11490  Chen Y, Sumardika IW, Tomonobu N, Winarsa Ruma IM, Kinoshita R, Kondo E, Inoue Y, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Liu M, Futami J, Sasai K, Katayama H, Kubo M, Putranto EW, Hibino T, Sun B, Nishibori M, Toyooka S, Sakaguchi M.  Melanoma cell adhesion molecule is the driving force behind the dissemination of melanoma upon S100A8/A9 binding in the original skin lesion.  Cancer Lett.  2019    PubMed ID: 30904617
5345  Yamaguchi S, Tanimoto A, Iwasa S, Otsuguro KI.  TRPM4 and TRPM5 Channels Share Crucial Amino Acid Residues for Ca2+ Sensitivity but Not Significance of PI(4,5)P2.  Int J Mol Sci  2019  20(8):2012  PubMed ID: 31022885
6833  Yokoyama T, Machida K, Iwasaki W, Shigeta T, Nishimoto M, Takahashi M, Sakamoto A, Yonemochi M, Harada Y, Shigematsu H, Shirouzu M, Tadakuma H, Imataka H, Ito T.  HCV IRES Captures an Actively Translating 80S Ribosome.  Mol Cell  2019  74(6):1205-1214  PubMed ID: 31080011
11500  Mizuta H, Kuga K, Suzuki T, Niwa Y, Dohmae N, Simizu S.  C‑mannosylation of R‑spondin2 activates Wnt/β‑catenin signaling and migration activity in human tumor cells.  Int. J. Oncol.  2019    PubMed ID: 30942431
11520  Liu YY, Tanikawa C, Ueda K, Matsuda K.  INKA2, a novel p53 target that interacts with the serine/threonine kinase PAK4.  Int. J. Oncol.  2019    PubMed ID: 31081062
11554  Matsubara H, Tanaka R, Tateishi T, Yoshida H, Yamaguchi M, Kataoka T.  The human Bcl-2 family member Bcl-rambo and voltage-dependent anion channels manifest a genetic interaction in Drosophila and cooperatively promote the activation of effector caspases in human cultured cells.  Exp. Cell Res.  2019    PubMed ID: 31102594
11555  Chen Y, Sumardika IW, Tomonobu N, Kinoshita R, Inoue Y, Iioka H, Mitsui Y, Saito K, Ruma IMW, Sato H, Yamauchi A, Murata H, Yamamoto KI, Tomida S, Shien K, Yamamoto H, Soh J, Futami J, Kubo M, Putranto EW, Murakami T, Liu M, Hibino T, Nishibori M, Kondo E, Toyooka S, Sakaguchi M.  Critical role of the MCAM-ETV4 axis triggered by extracellular S100A8/A9 in breast cancer aggressiveness.  Neoplasia  2019    PubMed ID: 31100639
11580  Tanaka J, Mabuchi Y, Hata K, Yasuhara R, Takamatsu K, Kujiraoka S, Yukimori A, Takakura I, Sumimoto H, Fukada T, Azuma M, Akiyama H, Nishimura R, Shimane T, Mishima K.  Sox9 regulates the luminal stem/progenitor cell properties of salivary glands.  Exp. Cell Res.  2019    PubMed ID: 31153924
11621  Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Ono T, Takagi T, Nakaya T, Matsumoto K, Watanabe Y.  PB2 mutations arising during H9N2 influenza evolution in the Middle East confer enhanced replication and growth in mammals.  PLoS Pathog.  2019    PubMed ID: 31265471
11624  Furuse Y, Chaimongkol N, Okamoto M, Oshitani H.  Evolutionary and Functional Diversity of the 5' Untranslated Region of Enterovirus D68: Increased Activity of the Internal Ribosome Entry Site of Viral Strains during the 2010s.  Viruses  2019    PubMed ID: 31288421
11643  Ishii J, Suzuki A, Kimura T, Tateyama M, Tanaka T, Yazawa T, Arimasu Y, Chen IS, Aoyama K, Kubo Y, Saitoh S, Mizuno H, Kamma H.  Congenital goitrous hypothyroidism is caused by dysfunction of the iodide transporter SLC26A7.  Commun Biol  2019    PubMed ID: 31372509
11647  Wong JH, Shigemizu D, Yoshii Y, Akiyama S, Tanaka A, Nakagawa H, Narumiya S, Fujimoto A.  Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population.  Genome Med  2019    PubMed ID: 31340865
11716  Makino Y, Jensen NH, Yokota N, Rossner MJ, Akiyama H, Shirahige K, Okada Y.  Single cell RNA-sequencing identified Dec2 as a suppressive factor for spermatogonial differentiation by inhibiting Sohlh1 expression.  Sci Rep  2019    PubMed ID: 30988352
11720  Yamanashi T, Maki M, Kojima K, Shibukawa A, Tsukamoto T, Chowdhury S, Yamanaka A, Takagi S, Sudo Y.  Quantitation of the neural silencing activity of anion channelrhodopsins in Caenorhabditis elegans and their applicability for long-term illumination.  Sci Rep  2019    PubMed ID: 31133660
11766  Su Y, Nichuguti N, Kuroki-Kami A, Fujiwara H.  Sequence-specific retrotransposition of 28S rDNA-specific LINE R2Ol in human cells.  RNA  2019    PubMed ID: 31434792
11845  Kamiki H, Matsugo H, Ishida H, Kobayashi-Kitamura T, Sekine W, Takenaka-Uema A, Murakami S, Horimoto T.  Adaptation of H3N2 canine influenza virus to feline cell culture.  PLoS ONE  2019    PubMed ID: 31600274
11854  Yamamoto M, Terada Y, Motoyama T, Saito T, Ito K.  Sweet proteins lysozyme and thaumatin are protein-type agonists for the calcium-sensing receptor.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31635806
11855  Morita A, Aoshima K, Gulay KCM, Onishi S, Shibata Y, Yasui H, Kobayashi A, Kimura T.  High drug efflux pump capacity and low DNA damage response induce doxorubicin resistance in canine hemangiosarcoma cell lines.  Res. Vet. Sci.  2019    PubMed ID: 31648115
6886  Musha S, Nagayama S, Murakami S, Kojima R, Deai M, Sato K, Okajima F, Ueharu H, Tomura H.  Protons Differentially Activate TDAG8 Homologs from Various Species.  Zoolog Sci  2019  36(2):105-111  PubMed ID: 31120644
6931  Nakanishi M, Hino M, Yoshimura M, Amakura Y, Nomoto H.  Identification of sinensetin and nobiletin as major antitrypanosomal factors in a citrus cultivar.  Exp Parasitol  2019  200:24-29  PubMed ID: 30898543
9468  Kazuyo Fujita, Masaharu Somiya, Shun'ichi Kuroda, Shuji Hinuma  Induction of Lipid Droplets in Non-Macrophage Cells as Well as Macrophages by Liposomes and Exosomes  Biochem Biophys Res Commun  2019  510(1):184-190  PubMed ID: 30678809
11909  Sakaue T, Hamaguchi M, Aono J, Nakashiro KI, Shikata F, Kawakami N, Oshima Y, Kurata M, Nanba D, Masumoto J, Yamaguchi O, Higashiyama S, Izutani H.  Valve Interstitial Cell-Specific Cyclooxygenase-1 Associated With Calcification of Aortic Valves.  Ann. Thorac. Surg.  2019    PubMed ID: 31760051
9500  Kanda K, Sakamoto J, Matsumoto Y, Ikuta K, Goto N, Morita Y, Ohno M, Nishi K, Eto K, Kimura Y, Nakanishi Y, Ikegami K, Yoshikawa T, Fukuda A, Kawada K, Sakai Y, Ito A, Yoshida M, Kimura T, Chiba T, Nishi E, Seno H.  Nardilysin controls intestinal tumorigenesis through HDAC1/p53-dependent transcriptional regulation.  JCI Insight  2018  3:  PubMed ID: 29669932
10788  Koshizuka T, Kobayashi T, Ishioka K, Suzutani T.  Herpesviruses possess conserved proteins for interaction with Nedd4 family ubiquitin E3 ligases.  Sci Rep  2018  8:4447  PubMed ID: 29535361
10808  Mochimaru Y, Negishi J, Murakami S, Musha S, Sato K, Okajima F, Tomura H.  Metals Differentially Activate Ovarian Cancer G Protein-Coupled Receptor 1 in Various Species.  Zool. Sci.  2018  35:109-114  PubMed ID: 29623784
10817  Yamashita W, Takahashi M, Kikkawa T, Gotoh H, Osumi N, Ono K, Nomura T.  Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.  Development  2018  145:  PubMed ID: 29661783
11042  Shigenori Inagaki; Masakazu Agetsuma; Takeharu Nagai  A novel fiber-free technique for brain activity imaging in multiple freely behaving mice  SPIE BiOS  2018   
11080  Wang Y, Cao L, Lee CY, Matsuo T, Wu K, Asher G, Tang L, Saitoh T, Russell J, Klewe-Nebenius D, Wang L, Soya S, Hasegawa E, Cherasse Y, Zhou J, Li Y, Wang T, Zhan X, Miyoshi C, Irukayama Y, Cao J, Meeks JP, Gautron L, Wang Z, Sakurai K, Funato H, Sakurai T, Yanagisawa M, Nagase H, Kobayakawa R, Kobayakawa K, Beutler B, Liu Q.  Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviors.  Nat Commun  2018  9(1):2041  PubMed ID: 29795268
11137  Iuchi K, Morisada Y, Yoshino Y, Himuro T, Saito Y, Murakami T, Hisatomi H.  Cold atmospheric-pressure nitrogen plasma induces the production of reactive nitrogen species and cell death by increasing intracellular calcium in HEK293T cells.  Arch. Biochem. Biophys.  2018  654:136-145  PubMed ID: 30026027
11144  Funakohi-Tago M, Sakata T, Fujiwara S, Sakakura A, Sugai T, Tago K, Tamura H.  Hydroxytyrosol butyrate inhibits 6-OHDA-induced apoptosis through activation of the Nrf2/HO-1 axis in SH-SY5Y cells.  Eur. J. Pharmacol.  2018  834:246-256  PubMed ID: 30053409
11189  Kawaguchi M, Tani T, Hombu R, Ieda N, Nakagawa H.  Development and cellular application of visible-light-controllable HNO releasers based on caged Piloty's acid.  Chem. Commun. (Camb.)  2018  54(73):10371-10374  PubMed ID: 30152479
11205  Shiozawa Y, Malcovati L, Galli A, Sato-Otsubo A, Kataoka K, Sato Y, Watatani Y, Suzuki H, Yoshizato T, Yoshida K, Sanada M, Makishima H, Shiraishi Y, Chiba K, Hellstrom-Lindberg E, Miyano S, Ogawa S, Cazzola M.  Aberrant splicing and defective mRNA production induced by somatic spliceosome mutations in myelodysplasia.  Nat Commun  2018    PubMed ID: 30194306
11222  Ageta H, Ageta-Ishihara N, Hitachi K, Karayel O, Onouchi T, Yamaguchi H, Kahyo T, Hatanaka K, Ikegami K, Yoshioka Y, Nakamura K, Kosaka N, Nakatani M, Uezumi A, Ide T, Tsutsumi Y, Sugimura H, Kinoshita M, Ochiya T, Mann M, Setou M, Tsuchida K.  UBL3 modification influences protein sorting to small extracellular vesicles.  Nat Commun  2018    PubMed ID: 30258067
11233  Aoshima K, Fukui Y, Gulay KCM, Erdemsurakh O, Morita A, Kobayashi A, Kimura T.  Notch2 signal is required for the maintenance of canine hemangiosarcoma cancer stem cell-like cells.  BMC Vet. Res.  2018    PubMed ID: 30285832
11156  Ito S, Kayukawa N, Ueda T, Taniguchi H, Morioka Y, Hongo F, Ukimura O.  MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.  Biochim Biophys Acta Gene Regul Mech  2018    PubMed ID: 30076933
11112  Niino T, Tago K, Yasuda D, Takahashi K, Mashino T, Tamura H, Funakoshi-Tago M.  A 5-hydroxyoxindole derivative attenuates LPS-induced inflammatory responses by activating the p38-Nrf2 signaling axis.  Biochem. Pharmacol.  2018  155:182-197  PubMed ID: 29940171
11217  Matsuura R, Kaji H, Tomioka A, Sato T, Narimatsu H, Moriwaki Y, Misawa H, Imai K, Tsuji S.  Identification of mesothelioma-specific sialylated epitope recognized with monoclonal antibody SKM9-2 in a mucin-like membrane protein HEG1.  Sci Rep  2018    PubMed ID: 30250045
11313  Kamiki H, Matsugo H, Kobayashi T, Ishida H, Takenaka-Uema A, Murakami S, Horimoto T.  A PB1-K577E Mutation in H9N2 Influenza Virus Increases Polymerase Activity and Pathogenicity in Mice.  Viruses  2018    PubMed ID: 30463209
11343  Saeki E, Yasuhira S, Shibazaki M, Tada H, Doita M, Masuda T, Maesawa C.  Involvement of C-terminal truncation mutation of kinesin-5 in resistance to kinesin-5 inhibitor.  PLoS ONE  2018    PubMed ID: 30557316
4118  Kandori S, Kojima T, Matsuoka T, Yoshino T, Sugiyama A, Nakamura E, Shimazui T, Funakoshi Y, Kanaho Y, Nishiyama H.  Phospholipase D2 promotes disease progression of renal cell carcinoma through the induction of angiogenin.  Cancer Sci.  2018    PubMed ID: 29660846
4119  Hirose Y, Onishi T, Miura S, Hatazawa Y, Kamei Y.  Vitamin D Attenuates FOXO1-Target Atrophy Gene Expression in C2C12 Muscle Cells.  J. Nutr. Sci. Vitaminol.  2018    PubMed ID: 29962435
4120  Miyagawa Y, Matsushita Y, Suzuki H, Komatsu M, Yoshimaru T, Kimura R, Yanai A, Honda J, Tangoku A, Sasa M, Miyoshi Y, Katagiri T.  Frequent downregulation of LRRC26 by epigenetic alterations is involved in the malignant progression of triple-negative breast cancer.  Int. J. Oncol.  2018    PubMed ID: 29512727
4121  Kumeta M, Panina Y, Yamazaki H, Takeyasu K, Yoshimura SH.  N-terminal dual lipidation-coupled molecular targeting into the primary cilium.  Genes Cells  2018    PubMed ID: 29900630
4122  Kato Y, Ninomiya K, Ohashi K, Tomida S, Makimoto G, Watanabe H, Kudo K, Matsumoto S, Umemura S, Goto K, Ichihara E, Ninomiya T, Kubo T, Sato A, Hotta K, Tabata M, Toyooka S, Maeda Y, Kiura K.  Combined effect of cabozantinib and gefitinib in crizotinib-resistant lung tumors harboring ROS1 fusions.  Cancer Sci.  2018    PubMed ID: 30053332
4279  Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, Fujihara-Iwata A, Hongo F, Okihara K, Ukimura O.  CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells.  Oncotarget  2018    PubMed ID: 29707137
4465  Watanabe Y, Arai Y, Kawashita N, Ibrahim MS, Elgendy EM, Daidoji T, Kajikawa J, Hiramatsu H, Sriwilaijaroen N, Ono T, Takagi T, Takahashi K, Shioda T, Matsumoto K, Suzuki Y, Nakaya T.  Characterization of H5N1 Influenza Virus Quasispecies with Adaptive Hemagglutinin Mutations from Single-Virus Infections of Human Airway Cells.  J. Virol.  2018  92(11)  PubMed ID: 29563293
4478  Omachi K, Kamura M, Teramoto K, Kojima H, Yokota T, Kaseda S, Kuwazuru J, Fukuda R, Koyama K, Matsuyama S, Motomura K, Shuto T, Suico MA, Kai H.  A Split-Luciferase-Based Trimer Formation Assay as a High-throughput Screening Platform for Therapeutics in Alport Syndrome.  Cell Chem Biol  2018  25(5):634-643.e4  PubMed ID: 29526710
9128  Asuka Yoshida, Ryoko Kawabata, Tomoyuki Honda, Kouji Sakai, Yasushi Ami, Takemasa Sakaguchi, Takashi Irie  A Single Amino Acid Substitution Within the Paramyxovirus Sendai Virus Nucleoprotein Is a Critical Determinant for Production of Interferon-Beta-Inducing Copyback-Type Defective Interfering Genomes  J Virol  2018  92 (5)   PubMed ID: 29237838
7011  Saito F, Hirayasu K, Satoh T, Wang CW, Lusingu J, Arimori T, Shida K, Palacpac NMQ, Itagaki S, Iwanaga S, Takashima E, Tsuboi T, Kohyama M, Suenaga T, Colonna M, Takagi J, Lavstsen T, Horii T, Arase H.  Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors.  Nature  2017  552:101-105  PubMed ID: 29186116
9849  Kanehira M, Fujiwara T, Nakajima S, Okitsu Y, Onishi Y, Fukuhara N, Ichinohasama R, Okada Y, Harigae H.  An Lysophosphatidic Acid Receptors 1 and 3 Axis Governs Cellular Senescence of Mesenchymal Stromal Cells and Promotes Growth and Vascularization of Multiple Myeloma.  Stem Cells  2017  35:739-753  PubMed ID: 27641212
9875  Chung J, Aburaya S, Aoki W, Ueda M.  Molecular changes in appearance of a cancer cell among normal HEK293T cells.  J. Biosci. Bioeng.  2017  123:281-286  PubMed ID: 27777049
10003  Takayama I, Tanabe H, Nishiyama T, Ito H, Amizuka N, Li M, Katsube KI, Kii I, Kudo A.  Periostin is required for matricellular localization of CCN3 in periodontal ligament of mice.  J Cell Commun Signal  2017  11:5-13  PubMed ID: 28013443
10065  Matsui T, Hori A, Hamako J, Matsushita F, Ozeki Y, Sakurai Y, Hayakawa M, Matsumoto M, Fujimura Y.  Mutant botrocetin-2 inhibits von Willebrand factor-induced platelet agglutination.  J. Thromb. Haemost.  2017  15:538-548  PubMed ID: 28071872
10081  Tsukamoto T, Chiba Y, Nakazaki A, Ishikawa Y, Nakane Y, Cho Y, Yotsu-Yamashita M, Nishikawa T, Wakamori M, Konoki K.  Inhibition of veratridine-induced delayed inactivation of the voltage-sensitive sodium channel by synthetic analogs of crambescin B.  Bioorg. Med. Chem. Lett.  2017  27:1247-1251  PubMed ID: 28143690
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10235  Goyal S, Suzuki T, Li JR, Maeda S, Kishima M, Nishimura H, Shimizu Y, Suzuki H.  RUNX1 induces DNA replication independent active DNA demethylation at SPI1 regulatory regions.  BMC Mol. Biol.  2017  18:9  PubMed ID: 28376714
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10548  Hirano K, Namihira M.  FAD influx enhances neuronal differentiation of human neural stem cells by facilitating nuclear localization of LSD1.  FEBS Open Bio  2017  7:1932-1942  PubMed ID: 29226080
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7180  Hang Q, Isaji T, Hou S, Im S, Fukuda T, Gu J.  Integrin α5 Suppresses the Phosphorylation of Epidermal Growth Factor Receptor and Its Cellular Signaling of Cell Proliferation via N-Glycosylation.  J. Biol. Chem.  2015  290:29345-60  PubMed ID: 26483551
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