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細胞番号 : 細胞名
RCB2145 : PC-3  update : 2021/04/16
細胞特性(Comment:英)Human cell line derived from bone metastasis of prostatic cancer. TKG0600 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト前立腺癌由来細胞株。骨転移巣より樹立。 TKG0600 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
寄託日 2005
元の細胞 TKG0600
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Caucasian
性別 Male
62 years
採取組織 prostate, bone meta
病名 prostatic carcinom
転移 Yes
転移巣 bone
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0600)
細胞寿命 infinite
細胞形態 epithelial-like
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 8 split
継代・培地交換頻度 Subculture : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
個体識別検査 OK
アイソザイム検査 LD, NP
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 4件
Reference(日) 0件
利用者成果(英) 39件
利用者成果(日) 1件

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Reference(英)
5121  Kirk D, Szalay MF, Kaighn ME.  Modulation of growth of a human prostatic cancer cell line (PC-3) in agar culture by normal human lung fibroblasts.  Cancer Res  1981  41(3):1100-3  PubMed ID: 7459854
5120  Ohnuki Y, Marnell MM, Babcock MS, Lechner JF, Kaighn ME.  Chromosomal analysis of human prostatic adenocarcinoma cell lines.  Cancer Res  1980  40(3):524-34  PubMed ID: 7471073
5118  Kaighn ME, Narayan KS, Ohnuki Y, Lechner JF, Jones LW.  Establishment and characterization of a human prostatic carcinoma cell line (PC-3).  Invest Urol  1979  17(1):16-23  PubMed ID: 447482
5119  Kaighn ME, Lechner JF, Narayan KS, Jones LW.  Prostate carcinoma: tissue culture cell lines.  Natl Cancer Inst Monogr  1978  (49):17-21  PubMed ID: 571045

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Reference(日)

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利用者成果(英)
13395  Imamura R, Kitagawa S, Kubo T, Irie A, Kariu T, Yoneda M, Kamba T, Imamura T.  Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a.  Prostate  2021    PubMed ID: 33368414
9833  Keiichi Oono, Kazuo Ohtake, Chie Watanabe, Sachiko Shiba, Takashi Sekiya, Keizo Kasono  Contribution of Pyk2 Pathway and Reactive Oxygen Species (ROS) to the Anti-Cancer Effects of Eicosapentaenoic Acid (EPA) in PC3 Prostate Cancer Cells  Lipids Health Dis  2020  19(1):15  PubMed ID: 32005121
12152  Shogo Nomura, Yasuko Egawa, Sayaka Urano, Tsuyoshi Tahara, Yasuyoshi Watanabe & Katsunori Tanaka  Cancer discrimination by on-cell N-glycan ligation  Communications Chemistry  2020   
10510  Kenward Vong, Tomoya Yamamoto, Tsung-che Changa and Katsunori Tanaka   Bioorthogonal release of anticancer drugs via gold-triggered 2-alkynylbenzamide cyclization  Chemical Science  2020  11:10928-10933 
13130  Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y.  Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement*.  Chembiochem  2020    PubMed ID: 32969164
13198  Hiromi I, Nakata S, Uenishi J.  Up-regulation of Death Receptor 5/TRAIL-R2 Mediates Apoptosis Induced by N,N'-[(3,4-dimethoxyphenyl)methylene] Biscinnamide in Cancer Cells.  Anticancer Res  2020    PubMed ID: 32878791
13264  Hikita T, Miyata M, Watanabe R, Oneyama C.  In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter.  Sci Rep  2020    PubMed ID: 33024173
13303  Uwada J, Nakazawa H, Mikami D, Islam MS, Muramatsu I, Taniguchi T, Yazawa T.  PNU-120596, a positive allosteric modulator of α7 nicotinic acetylcholine receptor, directly inhibits p38 MAPK.  Biochem Pharmacol  2020    PubMed ID: 33132165
13317  Fujita K, Kamiya M, Yoshioka T, Ogasawara A, Hino R, Kojima R, Ueo H, Urano Y.  Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C1.  ACS Cent Sci  2020    PubMed ID: 33376783
13591  Saiki I, Yara M, Yamanaka T, Uchino H, Inazu M.  Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target  Biomol Ther (Seoul)  2020  28(2):195-201  PubMed ID: 31693854
13771  F. Sima, H. Kawano, A. Miyawaki, K. Obata, D. Serien, K. Sugioka  3D glass nanofluidics fabricated by femtosecond laser processing for study of cancer cell metastasis and invasion  SPIE LASE  2020   
11271  Itoh A, Nonaka Y, Ogawa T, Nakamura T, Nishi N.  Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells.  Glycobiology  2019    PubMed ID: 30383222
11464  Ishigami-Yuasa M, Ekimoto H, Kagechika H.  Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer.  Biol. Pharm. Bull.  2019    PubMed ID: 30828077
11507  Murata K, Saga R, Monzen S, Tsuruga E, Hasegawa K, Hosokawa Y.  Understanding the mechanism underlying the acquisition of radioresistance in human prostate cancer cells.  Oncol Lett  2019    PubMed ID: 31186811
11639  Taniguchi K, Ii H, Kageyama S, Takagi H, Chano T, Kawauchi A, Nakata S.  Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis.  Biochem. Biophys. Res. Commun.  2019    PubMed ID: 31345573
11800  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Sci Rep  2019    PubMed ID: 31520002
11807  Takagi H, Ii H, Kageyama S, Hanada E, Taniguchi K, Yoshiya T, Chano T, Kawauchi A, Nakata S.  Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.  Anticancer Res.  2019    PubMed ID: 31519583
11717  K Hayashi et al  Optimization of Surface Treatment of MEMS Probes for Single-cell Capture and Release  Sensors and Materials  2019  31(9):2873 
13859  Park J, Komori T, Uda T, Miyajima K, Fujii T, Kim SH.  Sequential Cell-Processing System by Integrating Hydrodynamic Purification and Dielectrophoretic Trapping for Analyses of Suspended Cancer Cells  Micromachines (Basel)  2019  11(1):47  PubMed ID: 31905986
10845  Taniguchi K, Matsumura K, Ii H, Kageyama S, Ashihara E, Chano T, Kawauchi A, Yoshiki T, Nakata S.  Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence.  Am J Cancer Res  2018  8:650-661  PubMed ID: 29736310
11105  Senga S, Kobayashi N, Kawaguchi K, Ando A, Fujii H.  Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-κB) signaling in cancer cells.  Biochim Biophys Acta Mol Cell Biol Lipids  2018  1863(9):1057-1067  PubMed ID: 29906613
11160  Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O.  In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana.  J Evid Based Integr Med  2018    PubMed ID: 30088418
4319  Liu Q, Wu Y, Seino H, Haga T, Yoshizawa T, Morohashi S, Kijima H.  Correlation between DEC1/DEC2 and epithelial‑mesenchymal transition in human prostate cancer PC‑3 cells.  Mol Med Rep  2018    PubMed ID: 30106153
7050  Kajiura K, Masuda K, Naruto T, Kohmoto T, Watabnabe M, Tsuboi M, Takizawa H, Kondo K, Tangoku A, Imoto I.  Frequent silencing of the candidate tumor suppressor TRIM58 by promoter methylation in early-stage lung adenocarcinoma.  Oncotarget  2017  8:2890-2905  PubMed ID: 27926516
10506  Doi H, Kida T, Nishino K, Nakatsuji M, Sakamoto S, Shimizu S, Teraoka Y, Tamura Y, Kataoka Y, Inui T.  Solubility-Improved 10-O-Substituted SN-38 Derivatives with Antitumor Activity.  ChemMedChem  2017  12:1715-1722  PubMed ID: 28891271
10973    Dynamics of Morphological Changes of Adherent Cultured Cells at a Range of Low Temperatures near Physiological Temperature (Time-Lapse Imaging by Digital Holographic Microscopy)  Cryobiology and Cryotechnology  2017  63, 45~51 
4534  Cui C, Hanyu M, Hatori A, Zhang Y, Xie L, Ohya T, Fukada M, Suzuki H, Nagatsu K, Jiang C, Luo R, Shao G, Zhang M, Wang F.  Synthesis and evaluation of [64Cu]PSMA-617 targeted for prostate-specific membrane antigen in prostate cancer.  Am J Nucl Med Mol Imaging  2017  7(2):40-52  PubMed ID: 28533936
9615  Ohya S, Kanatsuka S, Hatano N, Kito H, Matsui A, Fujimoto M, Matsuba S, Niwa S, Zhan P, Suzuki T, Muraki K.  Downregulation of the Ca(2+)-activated K(+) channel KC a3.1 by histone deacetylase inhibition in human breast cancer cells.  Pharmacol Res Perspect  2016  4:e00228  PubMed ID: 27069638
9862  Sakura Y, Tsuboi K, Uyama T, Zhang X, Taoka R, Sugimoto M, Kakehi Y, Ueda N.  A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells.  Biochim. Biophys. Acta  2016  1861:1951-1958  PubMed ID: 27693242
10024  Matsumura K, Nakata S, Taniguchi K, Ii H, Ashihara E, Kageyama S, Kawauchi A, Yoshiki T.  Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation.  BMC Cancer  2016  16:748  PubMed ID: 27658708
10908    Extracts of Codiaeum variegatum (L.) A. Juss is Cytotoxic on Human Leukemic, Breast and Prostate Cancer Cell Lines  Journal of Applied Pharmaceutical Science  2016  6, 087-093 
6034  Liu Q, Wu Y, Yoshizawa T, Yan X, Morohashi S, Seino H, Kato Y, Kijima H.  Basic helix-loop-helix transcription factor DEC2 functions as an anti-apoptotic factor during paclitaxel-induced apoptosis in human prostate cancer cells.  Int J Mol Med  2016  38(6):1727-1733  PubMed ID: 27840924
12610  Zhang B, Shimada Y, Hirota T, Ariyoshi M, Kuroyanagi J, Nishimura Y, Tanaka T.  Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish  Transl Res  2016  170:89-98.e3  PubMed ID: 26746804
12621  Okada T, Uto K, Aoyagi T, Ebara M.  A biomimetic approach to hormone resistant prostate cancer cell isolation using inactivated Sendai virus (HVJ-E)  Biomater Sci  2016  4(1):96-103  PubMed ID: 26553555
12660  Thangavel S, Yoshitomi T, Sakharkar MK, Nagasaki Y.  Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects  Biomaterials  2016  99:109-23  PubMed ID: 27235996
12452  Kim SH, Fujii T.  Efficient analysis of a small number of cancer cells at the single-cell level using an electroactive double-well array  Lab Chip  2016  16(13):2440-9  PubMed ID: 27189335
7447  Sakane C, Ohta H, Shidoji Y.  Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry.  J Clin Biochem Nutr  2015  56:123-31  PubMed ID: 25759518
12866  Okada T, Niiyama E, Uto K, Aoyagi T, Ebara M.  Inactivated Sendai Virus (HVJ-E) Immobilized Electrospun Nanofiber for Cancer Therapy  Materials (Basel)  2015  9(1):12  PubMed ID: 28787810
5547  Orui H, Imaizumi S, Ogino T, Motoyama T.  Effects of bone morphogenetic protein-2 on human tumor cell growth and differentiation: a preliminary report.  J Orthop Sci  2000  5(6):600-4  PubMed ID: 11180925

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利用者成果(日)
11015    放射線刺激により誘発されるインターロイキン 34 の放射線治療抵抗性における潜在的役割について  聖マリアンナ医科大学雑誌  2017  45, 173-183 



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