検索画面
細胞材料開発室サイト

戻る 戻る
細胞番号 : 細胞名
RCB2144 : LNCap.FGC  update : 2021/11/04
細胞特性(Comment:英)Human cell line derived from prostate adenocarcinoma. Derived from lymph node metastasis. TKG0603 (Deposited from Tohoku Univ.).
細胞特性(日)ヒト前立腺癌由来細胞株。Adenocarcinoma。リンパ節転移細胞から樹立。 TKG0603 (東北大学医用細胞資源センターからの寄託)。
細胞特性(寄託者記述:英)
細胞特性(寄託者記述:日)
使用条件(英)There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
使用条件(日)基礎的研究につきましては、使用制限はありません。商業利用や特許取得を目的とする場合は、事前に必ず理研細胞バンクに連絡をすること。
備考(英)
備考(日)
提供申込書類(英) Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
提供申込書類(日) 依頼書C-0001.pdf   同意書(非営利学術目的)C-0003.pdf   同意書(営利目的)C-0003p.pdf  
提供同意書は、使用機関の種類や目的に応じて、非営利学術目的 (C-XXXX) と営利目的 (C-XXXXp) の2種類があります。該当する提供同意書をご使用ください(詳細)。特許等の取得及び商業利用等は事前に必ず(cellbank.brc@riken.jp)までご連絡ください。
提供手数料 手数料とお支払いについてはこちらをご覧ください。
細胞基本情報 寄託者 Obinata, Masuo
樹立者 Horoszewicz J.S.
寄託日 2005
元の細胞 TKG0603
動物種 _human < Mammals
属名 Homo
種名 sapiens
人種 Caucasian
性別 Male
50 years
採取組織 prostate, lymph node meta
病名 prostaric carcinoma
転移 Yes
転移巣 lymph node
細胞分類 cancer
入手歴 Cell Resource Center for Biomedical Research, Tohoku University(TKG0603)
細胞寿命 infinite
細胞形態 epithelial-like
Cellosaurus(Expasy) CVCL_1379
細胞培養・検査情報
寄託時情報
ロット情報
培地・試薬情報 培地・試薬一覧はこちらをご覧ください。
培養形態 Adherent cells
培地 RPMI1640 + 10% FBS
抗生物質 Free
継代方法 0.25% trypsin
継代密度 1 : 4 split
継代・培地交換頻度 Subculture : 1-2 times/week, Medium Renewal : 2 times/week
培養最適温度 37 ℃
二酸化炭素濃度 5 %
凍結培地 Medium + 10% DMSO
凍結方法 Slow freezing
マイコプラズマ (-)
アイソザイム検査 LD, NP
個体識別検査 OK
画像情報
寄託時情報
ロット情報
文献情報 Reference(英) 4件
Reference(日) 0件
利用者成果(英) 45件
利用者成果(日) 0件

トップへページトップへ
Reference(英)
5117  Deguchi T, Chu TM, Leong SS, Horoszewicz JS, Lee CL.  Effect of methotrexate-monoclonal anti-prostatic acid phosphatase antibody conjugate on human prostate tumor.  Cancer Res  1986  46(8):3751-5  PubMed ID: 3731053
5115  Gibas Z, Becher R, Kawinski E, Horoszewicz J, Sandberg AA.  A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP).  Cancer Genet Cytogenet  1984  11(4):399-404  PubMed ID: 6584201
5114  Horoszewicz JS, Leong SS, Kawinski E, Karr JP, Rosenthal H, Chu TM, Mirand EA, Murphy GP.  LNCaP model of human prostatic carcinoma.  Cancer Res  1983  3(4):1809-18  PubMed ID: 6831420
5116  Horoszewicz JS, Leong SS, Chu TM, Wajsman ZL, Friedman M, Papsidero L, Kim U, Chai LS, Kakati S, Arya SK, Sandberg AA.  The LNCaP cell line--a new model for studies on human prostatic carcinoma.  Prog Clin Biol Res  1980  37:115-32  PubMed ID: 384082

トップへページトップへ
Reference(日)

トップへページトップへ
利用者成果(英)
13130  Sasaki K, Harada M, Yoshikawa T, Tagawa H, Harada Y, Yonemitsu Y, Ryujin T, Kishimura A, Mori T, Katayama Y.  Fc-Binding Antibody-Recruiting Molecules Targeting Prostate-Specific Membrane Antigen: Defucosylation of Antibody for Efficacy Improvement*.  Chembiochem  2021  22(3):496-500  PubMed ID: 32969164
13393  Miyasaka K, Takeda S, Nakamura S, Matsuda H, Shimoda H.  Estrogenic and antiandrogenic activities of methoxyflavans isolated from the fruit of Mauritia Flexuosa (Moriche Palm).  J Food Biochem  2021    PubMed ID: 33340139
20249  Makise M, Uchimura R, Higashi K, Mashiki Y, Shiraishi R, Shutoku Y, Kuniyasu A.  Overexpression of the nucleoporin Nup88 stimulates migration and invasion of HeLa cells.  Histochem Cell Biol  2021    PubMed ID: 34331103
15709  Heishima K, Sugito N, Soga T, Nishikawa M, Ito Y, Honda R, Kuranaga Y, Sakai H, Ito R, Nakagawa T, Ueda H, Akao Y.  Petasin potently inhibits mitochondrial complex I-based metabolism that supports tumor growth and metastasis  J Clin Invest   2021  131(17):e139933  PubMed ID: 34623325
20406  Sawa C, Yofu S, Kiriyama K, Sutoh K, Saito T, Kishi S, Gunji M, Inoue Y, Sugi M, Shioda S, Honda K.  High concentration of extracellular nucleotides suppresses cell growth via delayed cell cycle progression in cancer and noncancer cell lines.  Heliyon  2021  7(11):e08318  PubMed ID: 34816032
12056  Ideo H, Kondo J, Nomura T, Nonomura N, Inoue M, Amano J.  Study of glycosylation of prostate-specific antigen secreted by cancer tissue-originated spheroids reveals new candidates for prostate cancer detection.  Sci Rep  2020    PubMed ID: 32066783
13264  Hikita T, Miyata M, Watanabe R, Oneyama C.  In vivo imaging of long-term accumulation of cancer-derived exosomes using a BRET-based reporter.  Sci Rep  2020    PubMed ID: 33024173
13317  Fujita K, Kamiya M, Yoshioka T, Ogasawara A, Hino R, Kojima R, Ueo H, Urano Y.  Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C1.  ACS Cent Sci  2020    PubMed ID: 33376783
13591  Saiki I, Yara M, Yamanaka T, Uchino H, Inazu M.  Functional Expression of Choline Transporter-Like Protein 1 in LNCaP Prostate Cancer Cells: A Novel Molecular Target  Biomol Ther (Seoul)  2020  28(2):195-201  PubMed ID: 31693854
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677
11446  Wada A, Terashima T, Kageyama S, Yoshida T, Narita M, Kawauchi A, Kojima H.  Efficient Prostate Cancer Therapy with Tissue-Specific Homing Peptides Identified by Advanced Phage Display Technology.  Mol Ther Oncolytics  2019    PubMed ID: 30788426
11507  Murata K, Saga R, Monzen S, Tsuruga E, Hasegawa K, Hosokawa Y.  Understanding the mechanism underlying the acquisition of radioresistance in human prostate cancer cells.  Oncol Lett  2019    PubMed ID: 31186811
11533  Saga R, Matsuya Y, Takahashi R, Hasegawa K, Date H, Hosokawa Y.  Analysis of the high-dose-range radioresistance of prostate cancer cells, including cancer stem cells, based on a stochastic model.  J. Radiat. Res.  2019    PubMed ID: 31034058
11591  Kawatani M, Yamamoto K, Yamada D, Kamiya M, Miyakawa J, Miyama Y, Kojima R, Morikawa T, Kume H, Urano Y.  Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity.  J. Am. Chem. Soc.  2019    PubMed ID: 31244179
11800  Koizumi A, Narita S, Nakanishi H, Ishikawa M, Eguchi S, Kimura H, Takasuga S, Huang M, Inoue T, Sasaki J, Yoshioka T, Habuchi T, Sasaki T.  Increased fatty acyl saturation of phosphatidylinositol phosphates in prostate cancer progression.  Sci Rep  2019    PubMed ID: 31520002
11807  Takagi H, Ii H, Kageyama S, Hanada E, Taniguchi K, Yoshiya T, Chano T, Kawauchi A, Nakata S.  Blockade of γ-Glutamylcyclotransferase Enhances Docetaxel Growth Inhibition of Prostate Cancer Cells.  Anticancer Res.  2019    PubMed ID: 31519583
6922  Soeda F, Watabe T, Naka S, Liu Y, Horitsugi G, Neels OC, Kopka K, Tatsumi M, Shimosegawa E, Giesel FL, Hatazawa J.  Impact of 18F-PSMA-1007 Uptake in Prostate Cancer Using Different Peptide Concentrations: Preclinical PET/CT Study on Mice.  J Nucl Med  2019  60(11):1594-1599  PubMed ID: 30902876
12506  Jin C, Zhao W, Zhang Z, Liu W.  Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer  Artif Cells Nanomed Biotechnol  2019  47(1):3350-3358  PubMed ID: 31387394
11152  Kamei H, Noguchi K, Matsuda H, Murata K.  Screening of Euphorbiaceae Plant Extracts for Anti-5α-reductase.  Biol. Pharm. Bull.  2018  41(8):1307-1310  PubMed ID: 30068884
11156  Ito S, Kayukawa N, Ueda T, Taniguchi H, Morioka Y, Hongo F, Ukimura O.  MRGBP promotes AR-mediated transactivation of KLK3 and TMPRSS2 via acetylation of histone H2A.Z in prostate cancer cells.  Biochim Biophys Acta Gene Regul Mech  2018    PubMed ID: 30076933
11160  Languon S, Tuffour I, Quayson EE, Appiah-Opong R, Quaye O.  In Vitro Evaluation of Cytotoxic Activities of Marketed Herbal Products in Ghana.  J Evid Based Integr Med  2018    PubMed ID: 30088418
4279  Ito S, Ueno A, Ueda T, Nakagawa H, Taniguchi H, Kayukawa N, Fujihara-Iwata A, Hongo F, Okihara K, Ukimura O.  CNPY2 inhibits MYLIP-mediated AR protein degradation in prostate cancer cells.  Oncotarget  2018    PubMed ID: 29707137
14599  Senga S, Kawaguchi K, Kobayashi N, Ando A, Fujii H.  A novel fatty acid-binding protein 5-estrogen-related receptor α signaling pathway promotes cell growth and energy metabolism in prostate cancer cells  Oncotarget  2018  9(60):31753-31770  PubMed ID: 30167092
10057  Li X, Wang X, Zhang J, Hanagata N, Wang X, Weng Q, Ito A, Bando Y, Golberg D.  Hollow boron nitride nanospheres as boron reservoir for prostate cancer treatment.  Nat Commun  2017  8:13936  PubMed ID: 28059072
10403  Qin H, Rasul A, Li X, Masood M, Yang G, Wang N, Wei W, He X, Watanabe N, Li J, Li X.  CD147-induced cell proliferation is associated with Smad4 signal inhibition.  Exp. Cell Res.  2017  358:279-289  PubMed ID: 28684116
10514  Kanayama M, Hayano T, Koebis M, Maeda T, Tabe Y, Horie S, Aiba A.  Hyperactive mTOR induces neuroendocrine differentiation in prostate cancer cell with concurrent up-regulation of IRF1.  Prostate  2017  77:1489-1498  PubMed ID: 28905415
11072  Hagiwara K, Tobisawa Y, Kaya T, Kaneko T, Hatakeyama S, Mori K, Hashimoto Y, Koie T, Suda Y, Ohyama C, Yoneyama T.  Wisteria floribunda Agglutinin and Its Reactive-Glycan-Carrying Prostate-Specific Antigen as a Novel Diagnostic and Prognostic Marker of Prostate Cancer.  Int J Mol Sci  2017    PubMed ID: 28134773
4534  Cui C, Hanyu M, Hatori A, Zhang Y, Xie L, Ohya T, Fukada M, Suzuki H, Nagatsu K, Jiang C, Luo R, Shao G, Zhang M, Wang F.  Synthesis and evaluation of [64Cu]PSMA-617 targeted for prostate-specific membrane antigen in prostate cancer.  Am J Nucl Med Mol Imaging  2017  7(2):40-52  PubMed ID: 28533936
14781  Fukami K, Asano E, Ueda M, Sekiguchi F, Yoshida S, Kawabata A.  High glucose induces N-linked glycosylation-mediated functional upregulation and overexpression of Ca v 3.2 T-type calcium channels in neuroendocrine-like differentiated human prostate cancer cells  J Pharmacol Sci  2017  133(1):57-6  PubMed ID: 28081948
9650  Ogura T, Tanaka Y, Tamaki H, Harada M.  Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells.  Int. J. Oncol.  2016  48:2330-8  PubMed ID: 27082738
9862  Sakura Y, Tsuboi K, Uyama T, Zhang X, Taoka R, Sugimoto M, Kakehi Y, Ueda N.  A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells.  Biochim. Biophys. Acta  2016  1861:1951-1958  PubMed ID: 27693242
9868  Ito H, Yamaguchi N, Onimaru M, Kimura S, Ohmori T, Ishikawa F, Sato J, Ito S, Inoue H.  Change in number and size of circulating tumor cells with high telomerase activity during treatment of patients with gastric cancer.  Oncol Lett  2016  12:4720-4726  PubMed ID: 28105179
10024  Matsumura K, Nakata S, Taniguchi K, Ii H, Ashihara E, Kageyama S, Kawauchi A, Yoshiki T.  Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation.  BMC Cancer  2016  16:748  PubMed ID: 27658708
10905    Roasted coffee induction of aldo-keto reductase 1C3 expression in LNCaP human prostate cancer cells is associated with Nrf2 activation  Oncology Letters  2016  12, 5321-5326 
12204  Minhui Xu, Shinichi Sakamoto, Jun Matsushima, Toru Kimura, Takeshi Ueda, Atsushi Mizokami, Yoshikatsu Kanai, Tomohiko Ichikawa  Up-Regulation of LAT1 during Antiandrogen Therapy Contributes to Progression in Prostate Cancer Cells  J Urol  2016  195(5):1588-1597  PubMed ID: 26682754
12621  Okada T, Uto K, Aoyagi T, Ebara M.  A biomimetic approach to hormone resistant prostate cancer cell isolation using inactivated Sendai virus (HVJ-E)  Biomater Sci  2016  4(1):96-103  PubMed ID: 26553555
12637  Kawaguchi K, Kinameri A, Suzuki S, Senga S, Ke Y, Fujii H.  The cancer-promoting gene fatty acid-binding protein 5 (FABP5) is epigenetically regulated during human prostate carcinogenesis  Biochem J  2016  473(4):449-61  PubMed ID: 26614767
12660  Thangavel S, Yoshitomi T, Sakharkar MK, Nagasaki Y.  Redox nanoparticle increases the chemotherapeutic efficiency of pioglitazone and suppresses its toxic side effects  Biomaterials  2016  99:109-23  PubMed ID: 27235996
12683  Matsushita S, Suzuki K, Ogino Y, Hino S, Sato T, Suyama M, Matsumoto T, Omori A, Inoue S, Yamada G.  Androgen Regulates Mafb Expression Through its 3'UTR During Mouse Urethral Masculinization  Endocrinology  2016  157(2):844-57.  PubMed ID: 26636186
14128  REGINA APPIAH-OPONG, ISAAC KWADWO ASANTE, DORCAS OSEI SAFO, ISAAC TUFFOUR, EBENEZER OFORI- ATTAH, TAKUHIRO UTO, ALEXANDER KWADWO NYARKO  Cytotoxic effects of Albizia zygia (DC) JF Macbr, a Ghanaian medicinal plant, against human T-lymphoblast-like leukemia, prostate and breast cancer cell lines  International Journal of Pharmacy and Pharmaceutical Sciences  2016  8 
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144
6398  Nagano K, Yamashita T, Inoue M, Higashisaka K, Yoshioka Y, Abe Y, Mukai Y, Kamada H, Tsutsumi Y, Tsunoda S  Eph receptor A10 has a potential as a target for a prostate cancer therapy.  Biochem Biophys Res Commun  2014  450(1):545-9  PubMed ID: 24924629
7747  Qin XY, Zaha H, Nagano R, Yoshinaga J, Yonemoto J, Sone H.  Xenoestrogens down-regulate aryl-hydrocarbon receptor nuclear translocator 2 mRNA expression in human breast cancer cells via an estrogen receptor alpha-dependent mechanism.  Toxicol. Lett.  2011  206:152-7  PubMed ID: 21771643
8419  Fukushima K, Satoh T, Baba S, Yamashita K.  alpha1,2-Fucosylated and beta-N-acetylgalactosaminylated prostate-specific antigen as an efficient marker of prostatic cancer.  Glycobiology  2010  20:452-60  PubMed ID: 20008118
10094  Fischer P, Kipp W, Bamuhiga J, Binta-Kahwa J, Kiefer A, Büttner DW.  Parasitological and clinical characterization of Simulium neavei-transmitted onchocerciasis in western Uganda.  Trop. Med. Parasitol.  1993  44:311-21  PubMed ID: 8134773

トップへページトップへ
利用者成果(日)



戻る 戻る 理研トップページへ