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Cell No. : Cell Name
RCB2127 : COLO205  update : 2021/05/20
CommentHuman cell line derived from colon cancer. Derived from ascites metastasis. TKG0457 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2005
Original cell TKG0457
Animal human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 70 years
Tissue colon, ascites meta
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0457)
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0218
deposit info
lot info
Medium Medium List
Culture type Adherent/Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method pipetting
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : 1-2 times/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 1
User's Publication 25


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Reference
5100  Semple TU, Quinn LA, Woods LK, Moore GE.  Tumor and lymphoid cell lines from a patient with carcinoma of the colon for a cytotoxicity model.  Cancer Res  1978  38(5):1345-55  PubMed ID: 565251  

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User's Publication
16349  Takeda T, Yamamoto Y, Tsubaki M, Matsuda T, Kimura A, Shimo N, Nishida S.  PI3K/Akt/YAP signaling promotes migration and invasion of DLD-1 colorectal cancer cells  Oncol Lett  2022  23(4):106  PubMed ID: 35242234   DOI: 10.3892/ol.2022.13226
15080  Hirashita Y, Tsukamoto Y, Kudo Y, Kakisako D, Kurogi S, Hijiya N, Nakada C, Uchida T, Hirashita T, Hiratsuka T, Akagi T, Ueda Y, Shiroshita H, Etoh T, Mizukami K, Honda K, Okimoto T, Kodama M, Inomata M, Moriyama M, Murakami K.  Early response in phosphorylation of ribosomal protein S6 is associated with sensitivity to trametinib in colorectal cancer cells  Lab Invest  2021  101(8):1036-1047  PubMed ID: 33911189   DOI: 10.1038/s41374-021-00590-w
6918  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.  Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.  Cell Chem Biol  2020  27(2):186-196  PubMed ID: 31813846   DOI: 10.1016/j.chembiol.2019.11.010
9913  Satoshi Inoue, Takumi Tsunoda, Miho Riku, Hideaki Ito, Akihito Inoko, Hideki Murakami, Masahide Ebi, Naotaka Ogasawara, Ira Pastan, Kunio Kasugai, Kenji Kasai, Hiroshi Ikeda, Shingo Inaguma  Diffuse Mesothelin Expression Leads to Worse Prognosis Through Enhanced Cellular Proliferation in Colorectal Cancer  Oncol Lett  2020  19(3):1741-1750  PubMed ID: 32194667   DOI: 10.3892/ol.2020.11290
11905  Igarashi H, Taniguchi H, Nosho K, Ishigami K, Koide H, Mitsuhashi K, Okita K, Takemasa I, Imai K, Nakase H.  PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer.  Clin Transl Oncol  2020  22(7):1126-1137  PubMed ID: 31741141   DOI: 10.1007/s12094-019-02239-z
13234  Nishimoto A, Takemoto Y, Saito T, Kurazumi H, Tanaka T, Harada E, Shirasawa B, Hamano K.  Nuclear β-catenin expression is positively regulated by JAB1 in human colorectal cancer cells.  Biochem Biophys Res Commun  2020    PubMed ID: 32977947   DOI: 10.1016/j.bbrc.2020.09.007
13502  Nambara S, Masuda T, Kobayashi Y, Sato K, Tobo T, Koike K, Noda M, Ogawa Y, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Mimori K.  GTF2IRD1 on chromosome 7 is a novel oncogene regulating the tumor-suppressor gene TGFβR2 in colorectal cancer  Cancer Sci  2020  111(2):343-355  PubMed ID: 31758608   DOI: 10.1111/cas.14248
11913  Tsubaki M, Takeda T, Noguchi M, Jinushi M, Seki S, Morii Y, Shimomura K, Imano M, Satou T, Nishida S.  Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells.  Cancers (Basel)  2019    PubMed ID: 31769426   DOI: 10.3390/cancers11121866
12405  Kouyama Y, Masuda T, Fujii A, Ogawa Y, Sato K, Tobo T, Wakiyama H, Yoshikawa Y, Noda M, Tsuruda Y, Kuroda Y, Eguchi H, Ishida F, Kudo SE, Mimori K.  Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer  Cancer Sci   2019  110(10):3132-3144  PubMed ID: 31390121   DOI: 10.1111/cas.14163
10556  Tsubaki M, Takeda T, Asano RT, Matsuda T, Fujimoto SI, Itoh T, Imano M, Satou T, Nishida S.  Rebamipide suppresses 5-fluorouracil-induced cell death via the activation of Akt/mTOR pathway and regulates the expression of Bcl-2 family proteins.  Toxicol In Vitro  2018  46:284-293  PubMed ID: 29054700   DOI: 10.1016/j.tiv.2017.10.019
10702  Horibe S, Tanahashi T, Kawauchi S, Murakami Y, Rikitake Y.  Mechanism of recipient cell-dependent differences in exosome uptake.  BMC Cancer  2018  18:47  PubMed ID: 29306323   DOI: 10.1186/s12885-017-3958-1
10185  Yokoi K, Yamashita K, Ishii S, Tanaka T, Nishizawa N, Tsutsui A, Miura H, Katoh H, Yamanashi T, Naito M, Sato T, Nakamura T, Watanabe M.  Comprehensive molecular exploration identified promoter DNA methylation of the CRBP1 gene as a determinant of radiation sensitivity in rectal cancer.  Br. J. Cancer  2017  116:1046-1056  PubMed ID: 28291773   DOI: 10.1038/bjc.2017.65
10498  Inaguma S, Lasota J, Felisiak-Golabek A, Kowalik A, Wang Z, Zieba S, Kalisz J, Ikeda H, Miettinen M.  Histopathological and genotypic characterization of metastatic colorectal carcinoma with PD-L1 (CD274)-expression: Possible roles of tumour micro environmental factors for CD274 expression.  J Pathol Clin Res  2017  3:268-278  PubMed ID: 29085667   DOI: 10.1002/cjp2.81
9176  Yasuteru Fujino, Shunsaku Takeishi, Kensei Nishida, Koichi Okamoto, Naoki Muguruma, Tetsuo Kimura, Shinji Kitamura, Hiroshi Miyamoto, Akiko Fujimoto, Jun Higashijima, Mitsuo Shimada, Kazuhito Rokutan, Tetsuji Takayama  Downregulation of microRNA-100/microRNA-125b Is Associated With Lymph Node Metastasis in Early Colorectal Cancer With Submucosal Invasion  Cancer Sci  2017  108 (3), 390-397  PubMed ID: 28032929   DOI: 10.1111/cas.13152
10027  Yasuyuki Okada, Tetsuo Kimura, Tadahiko Nakagawa, Koichi Okamoto, Akira Fukuya, Takahiro Goji, Shota Fujimoto, Masahiro Sogabe, Hiroshi Miyamoto, Naoki Muguruma, Yasushi Tsuji, Toshiya Okahisa, Tetsuji Takayama  EGFR Downregulation After Anti-EGFR Therapy Predicts the Antitumor Effect in Colorectal Cancer  Mol Cancer Res  2017  15(10):1445-1454  PubMed ID: 28698359   DOI: 10.1158/1541-7786.MCR-16-0383
14055  Morishita S, Suzuki T, Niwa Y, Dohmae N, Simizu S.  Dpy-19 like 3-mediated C-mannosylation and expression levels of RPE-spondin in human tumor cell lines  Oncol Lett  2017  14(2):2537-2544  PubMed ID: 28781692   DOI: 10.3892/ol.2017.6465
12615  Tokunaga R, Sakamoto Y, Nakagawa S, Miyake K, Izumi D, Kosumi K, Taki K, Higashi T, Imamura Y, Ishimoto T, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer  Ann Surg Oncol  2016  23(2):678-85  PubMed ID: 26416711   DOI: 10.1245/s10434-015-4879-3
14105  Matsuda Y, Miura K, Yamane J, Shima H, Fujibuchi W, Ishida K, Fujishima F, Ohnuma S, Sasaki H, Nagao M, Tanaka N, Satoh K, Naitoh T, Unno M.  SERPINI1 regulates epithelial-mesenchymal transition in an orthotopic implantation model of colorectal cancer  Cancer Sci  2016  107(5):619-28  PubMed ID: 26892864   DOI: 10.1111/cas.12909
15077  Kloth M, Ruesseler V, Engel C, Koenig K, Peifer M, Mariotti E, Kuenstlinger H, Florin A, Rommerscheidt-Fuss U, Koitzsch U, Wodtke C, Ueckeroth F, Holzapfel S, Aretz S, Propping P, Loeffler M, Merkelbach-Bruse S, Odenthal M, Friedrichs N, Heukamp LC, Zander T, Buettner R.  Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer  Gut  2016  65(8):1296-305  PubMed ID: 26001389   DOI: 10.1136/gutjnl-2014-309026
10157  Naruji Kugimiya, Arata Nishimoto, Tohru Hosoyama, Koji Ueno, Tadahiko Enoki, Tao-Sheng Li, Kimikazu Hamano  The c-MYC-ABCB5 Axis Plays a Pivotal Role in 5-fluorouracil Resistance in Human Colon Cancer Cells  J Cell Mol Med  2015  19(7):1569-81  PubMed ID: 25689483   DOI: 10.1111/jcmm.12531
10158  Takuma Yoshinaga, Takamasa Shigemitsu, Hiroto Nishimata, Masaki Kitazono, Emiko Hori, Ayako Tomiyoshi, Takayuki Takei, Masahiro Yoshida  Angiopoietin-like Protein 2 as a Potential Biomarker for Colorectal Cancer  Mol Clin Oncol  2015  3(5):1080-1084  PubMed ID: 26623054   DOI: 10.3892/mco.2015.577
15139  Ida S, Ozaki N, Araki K, Hirashima K, Zaitsu Y, Taki K, Sakamoto Y, Miyamoto Y, Oki E, Morita M, Watanabe M, Maehara Y, Yamamura K, Baba H, Ohmuraya M.  SPINK1 Status in Colorectal Cancer, Impact on Proliferation, and Role in Colitis-Associated Cancer  Mol Cancer Res  2015  13(7):1130-8  PubMed ID: 25804623   DOI: 10.1158/1541-7786.MCR-14-0581
17139  Manthana Mitchai, Niramon Leeratanapetch, Viraphong Lulitanond, Pattaravadee Srikoon, Shinichiro Hattori, Kulthida Vaeteewoottacharn, Sopit Wongkham, Seiji Okada  Phenotypic Characteristics and Function of NK Cell Subsets in cART-Treated HIV-1-Infected Individuals  World Journal of AIDS  2014  04:293-300    DOI: 10.4236/wja.2014.43034
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
15636  Sasaki H, Miura K, Horii A, Kaneko N, Fujibuchi W, Kiseleva L, Gu Z, Murata Y, Karasawa H, Mizoi T, Kobayashi T, Kinouchi M, Ohnuma S, Yazaki N, Unno M, Sasaki I.  Orthotopic implantation mouse model and cDNA microarray analysis indicates several genes potentially involved in lymph node metastasis of colorectal cancer  Cancer Sci  2008  99(4):711-9  PubMed ID: 18307535   DOI: 10.1111/j.1349-7006.2008.00725.x



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