CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2102 : HO-1-u-1]

5088 Sugiyama A, Ishiguro M, Yasue T, Watanabe S, Sugishita N, Yokoyama H, Uno T, Watanabe H, Matsuno Y, Sasaoka I. An autopsy case of triple cancer associated with superior vena cava syndrome Gan No Rinsho 1985 31(10):1347-52 PubMed ID: 2997498

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19591 Kawasaki Y, Omori Y, Suzuki S, Yamada T. CD98hc as a marker of radiotherapy-resistant cancer stem cells in head and neck squamous cell carcinoma Arch Med Sci 2023 19(6):1859-1868 PubMed ID: 38058706 DOI: 10.5114/aoms.2020.92872

20559 Komatsu M, Saito K, Miyamoto I, Koike K, Iyoda M, Nakashima D, Kasamatsu A, Shiiba M, Tanzawa H, Uzawa K. Aberrant GIMAP2 expression affects oral squamous cell carcinoma progression by promoting cell cycle and inhibiting apoptosis. Oncol Lett 2022 23(2):49 PubMed ID: 34992682 DOI: 10.3892/ol.2021.13167

20020 Shishido K, Kuroishi T, Sugawara S. P2 purinergic receptor signaling and interleukin-1 synergistically induce interleukin-6 production in a human oral squamous carcinoma cell line. J Oral Biosci 2021 PubMed ID: 33497843 DOI: 10.1016/j.job.2021.01.004

20085 Kase Y, Uzawa K, Wagai S, Yoshimura S, Yamamoto JI, Toeda Y, Okubo M, Eizuka K, Ando T, Nobuchi T, Kawasaki K, Saito T, Iyoda M, Nakashima D, Kasamatsu A, Tanzawa H. Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression. Sci Rep 2021 11(1):5897 PubMed ID: 33723306 DOI: 10.1038/s41598-021-85242-1

16206 Koma A, Asai S, Minemura C, Oshima S, Kinoshita T, Kikkawa N, Koshizuka K, Moriya S, Kasamatsu A, Hanazawa T, Uzawa K, Seki N. Impact of Oncogenic Targets by Tumor-Suppressive miR-139-5p and miR-139-3p Regulation in Head and Neck Squamous Cell Carcinoma Int J Mol Sci 2021 22(18):9947 PubMed ID: 34576110 DOI: 10.3390/ijms22189947

16975 Hotta H, Hamamura K, Shibuya H, Ohmi Y, Furukawa K, Furukawa K. Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling Anticancer Res 2021 41(4):1821-1830 PubMed ID: 33813387 DOI: 10.21873/anticanres.14948

13903 Aika Tanzawa et al. Comprehensive gene expression analysis of semaphorins in oral squamous cell carcinoma Oral Science International 2020 17(2):67-72 DOI: 10.1002/osi2.1044

11354 Nakamura Y, Nakahata S, Kondo Y, Izumi A, Yamamoto K, Ichikawa T, Tamura T, Noumi K, Yamashita Y, Morishita K. Overexpression of absent in melanoma 2 in oral squamous cell carcinoma contributes to tumor progression. Biochem. Biophys. Res. Commun. 2019 PubMed ID: 30587341 DOI: 10.1016/j.bbrc.2018.12.066

9696 Kazuya Hiroshima, Masashi Shiiba, Noritoshi Oka, Fumihiko Hayashi, Sho Ishida, Reo Fukushima, Kazuyuki Koike, Manabu Iyoda, Dai Nakashima, Hideki Tanzawa, Katsuhiro Uzawa Tspan15 Plays a Crucial Role in Metastasis in Oral Squamous Cell Carcinoma Exp Cell Res 2019 384(2):111622 PubMed ID: 31518558 DOI: 10.1016/j.yexcr.2019.111622

11907 Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S, D'Amico C, De Stefano R, Troiano G, Santoro R, Laino L, Laino G, Cicciù M. Molecular Biomarkers Related to Oral Carcinoma: Clinical Trial Outcome Evaluation in a Literature Review. Dis. Markers 2019 PubMed ID: 31019584 DOI: 10.1155/2019/8040361

12586 Sato K, Shi L, Ito F, Ohara Y, Motooka Y, Tanaka H, Mizuno M, Hori M, Hirayama T, Hibi H, Toyokuni S. Non-thermal plasma specifically kills oral squamous cell carcinoma cells in a catalytic Fe(II)-dependent manner J Clin Biochem Nutr 2019 65(1):8-15 PubMed ID: 31379408 DOI: 10.3164/jcbn.18-91

10682 Yamamoto JI, Kasamatsu A, Okubo Y, Nakashima D, Fushimi K, Minakawa Y, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer. Biochem. Biophys. Res. Commun. 2018 495:2469-2474 PubMed ID: 29278705 DOI: 10.1016/j.bbrc.2017.12.138

10683 Suzuki S, Hoshino H, Yoshida K, Nakanishi J, Tsuchiya-Hirata S, Kobuke S, Haruyama N, Nishimura F, Shiba H. Genome-wide identification of chromatin-enriched RNA reveals that unspliced dentin matrix protein-1 mRNA regulates cell proliferation in squamous cell carcinoma. Biochem. Biophys. Res. Commun. 2018 495:2303-2309 PubMed ID: 29278708 DOI: 10.1016/j.bbrc.2017.12.136

10806 Okubo Y, Kasamatsu A, Yamatoji M, Fushimi K, Ishigami T, Shimizu T, Kasama H, Shiiba M, Tanzawa H, Uzawa K. Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell-cycle progression. Exp. Cell Res. 2018 367:112-118 PubMed ID: 29614312 DOI: 10.1016/j.yexcr.2018.03.041

10820 Fukamachi M, Kasamatsu A, Endo-Sakamoto Y, Fushimi K, Kasama H, Iyoda M, Minakawa Y, Shiiba M, Tanzawa H, Uzawa K. Multiple coagulation factor deficiency protein 2 as a crucial component in metastasis of human oral cancer. Exp. Cell Res. 2018 368:119-125 PubMed ID: 29679592 DOI: 10.1016/j.yexcr.2018.04.021

11180 Toeda Y, Kasamatsu A, Koike K, Endo-Sakamoto Y, Fushimi K, Kasama H, Yamano Y, Shiiba M, Tanzawa H, Uzawa K. FBLIM1 enhances oral cancer malignancy via modulation of the epidermal growth factor receptor pathway. Mol. Carcinog. 2018 57(12):1690-1697 PubMed ID: 30129678 DOI: 10.1002/mc.22889

11192 Miyaguchi J, Shiga K, Ogawa K, Suzuki F, Katagiri K, Saito D, Ikeda A, Horii A, Watanabe M, Igimi S. Treatment with Lactobacillus Retards the Tumor Growth of Head and Neck Squamous Cell Carcinoma Cells Inoculated in Mice. Tohoku J. Exp. Med. 2018 245(4):269-275 PubMed ID: 30158369 DOI: 10.1620/tjem.245.269

11226 Fukushima R, Kasamatsu A, Nakashima D, Higo M, Fushimi K, Kasama H, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of Translocation Associated Membrane Protein 2 Leading to Cancer-Associated Matrix Metalloproteinase Activation as a Putative Metastatic Factor for Human Oral Cancer. J Cancer 2018 PubMed ID: 30271493 DOI: 10.7150/jca.25666

4345 Hou B, Ishinaga H, Midorikawa K, Nakamura S, Hiraku Y, Oikawa S, Ma N, Takeuchi K, Murata M. Let-7c inhibits migration and epithelial-mesenchymal transition in head and neck squamous cell carcinoma by targeting IGF1R and HMGA2. Oncotarget 2018 PubMed ID: 29507664 DOI: 10.18632/oncotarget.23826

16201 Sawai Y, Kasamatsu A, Nakashima D, Fushimi K, Kasama H, Iyoda M, Kouzu Y, Shiiba M, Tanzawa H, Uzawa K. Critical role of deoxynucleotidyl transferase terminal interacting protein 1 in oral cancer Lab Invest 2018 98(8):980-988 PubMed ID: 29855544 DOI: 10.1038/s41374-018-0070-3

10148 Takahara T, Kasamatsu A, Yamatoji M, Iyoda M, Kasama H, Saito T, Takeuchi S, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7. Exp. Cell Res. 2017 352:357-363 PubMed ID: 28237246 DOI: 10.1016/j.yexcr.2017.02.026

10155 Koide N, Kasamatsu A, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Evidence for Critical Role of Lymphocyte Cytosolic Protein 1 in Oral Cancer. Sci Rep 2017 7:43379 PubMed ID: 28230172 DOI: 10.1038/srep43379

10191 Takeuchi S, Kasamatsu A, Yamatoji M, Nakashima D, Endo-Sakamoto Y, Koide N, Takahara T, Shimizu T, Iyoda M, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. TEAD4-YAP interaction regulates tumoral growth by controlling cell-cycle arrest at the G1 phase. Biochem. Biophys. Res. Commun. 2017 486:385-390 PubMed ID: 28315328 DOI: 10.1016/j.bbrc.2017.03.050

10418 Kita A, Kasamatsu A, Nakashima D, Endo-Sakamoto Y, Ishida S, Shimizu T, Kimura Y, Miyamoto I, Yoshimura S, Shiiba M, Tanzawa H, Uzawa K. Activin B Regulates Adhesion, Invasiveness, and Migratory Activities in Oral Cancer: a Potential Biomarker for Metastasis. J Cancer 2017 8:2033-2041 PubMed ID: 28819404 DOI: 10.7150/jca.18714

11036 Increased Expression of CD44v9, A Cancer Stem Cell Marker, in Head And Neck Squamous Cell Carcinoma Cells after Irradiation Int J Cancer Oncol 2017 4: 225- 230 DOI: 10.15436/2377-0902.17.1628

6027 lNorihisa Ichimura et al Notch3 is frequently downregulated in oral cancer Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 2017 29:504-510 DOI: 10.1016/j.ajoms.2017.06.006

6029 Ishida S　et al Novel mechanism of aberrant ZIP4 expression with zinc supplementation in oral tumorigenesis. Biochem Biophys Res Commun 2017 483(1):339-345 PubMed ID: 28017725 DOI: 10.1016/j.bbrc.2016.12.142

12679 Tamura T, Ichikawa T, Nakahata S, Kondo Y, Tagawa Y, Yamamoto K, Nagai K, Baba T, Yamaguchi R, Futakuchi M, Yamashita Y, Morishita K. Loss of NDRG2 Expression Confers Oral Squamous Cell Carcinoma with Enhanced Metastatic Potential Cancer Res 2017 77(9):2363-2374 PubMed ID: 28209617 DOI: 10.1158/0008-5472.CAN-16-2114

14306 Noriko Komatsu, Kenichi Mitsui, Osamu Kusano-Arai, Hiroko Iwanari, Kazuto Hoshi, Tsuyoshi Takato, Takahiro Abe and Takao Hamakubo Enhancement of anti-robo1 immunotoxin cytotoxicity to head and neck squamous cell carcinoma via photochemical internalization Archives in Cancer Research 2017 5

9616 Kitajima D, Kasamatsu A, Nakashima D, Miyamoto I, Kimura Y, Saito T, Suzuki T, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Tie2 Regulates Tumor Metastasis of Oral Squamous Cell Carcinomas. J Cancer 2016 7:600-7 PubMed ID: 27053959 DOI: 10.7150/jca.13820

9630 Kimura Y, Kasamatsu A, Nakashima D, Yamatoji M, Minakawa Y, Koike K, Fushimi K, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. ARNT2 Regulates Tumoral Growth in Oral Squamous Cell Carcinoma. J Cancer 2016 7:702-10 PubMed ID: 27076852 DOI: 10.7150/jca.14208

6036 Suzuki T, Kasamatsu A, Miyamoto I, Saito T, Higo M, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Overexpression of TMOD1 is associated with enhanced regional lymph node metastasis in human oral cancer. Int J Oncol. 2016 48(2):607-12 PubMed ID: 26718916 DOI: 10.3892/ijo.2015.3305

7442 Shirako Y, Taya Y, Sato K, Chiba T, Imai K, Shimazu Y, Aoba T, Soeno Y. Heterogeneous tumor stromal microenvironments of oral squamous cell carcinoma cells in tongue and nodal metastatic lesions in a xenograft mouse model. J. Oral Pathol. Med. 2015 44:656-68 PubMed ID: 25765182 DOI: 10.1111/jop.12318

6044 Kasama H　et al Adenosine A2b receptor promotes progression of human oral cancer. BMC Cancer 2015 15:563 PubMed ID: 26228921 DOI: 10.1186/s12885-015-1577-2

6051 Okamoto A　et al Down-Regulation of Nucleolar and Spindle-Associated Protein 1 (NUSAP1) Expression Suppresses Tumor and Cell Proliferation and Enhances Anti-Tumor Effect of Paclitaxel in Oral Squamous Cell Carcinoma. PLoS One 2015 10(11):e0142252 PubMed ID: 26554377 DOI: 10.1371/journal.pone.0142252

6052 Saito T et al Semaphorin7A Promotion of Tumoral Growth and Metastasis in Human Oral Cancer by Regulation of G1 Cell Cycle and Matrix Metalloproteases: Possible Contribution to Tumoral Angiogenesis. PLoS One 2015 10(9):e0137923 PubMed ID: 26378920 DOI: 10.1371/journal.pone.0137923

6058 Shida-Sakazume T et al Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. PLoS One. 2015 10(3):e0120143 PubMed ID: 25803864 DOI: 10.1371/journal.pone.0120143

14987 Kaneko T, Kanno C, Ichikawa-Tomikawa N, Kashiwagi K, Yaginuma N, Ohkoshi C, Tanaka M, Sugino T, Imura T, Hasegawa H, Chiba H. Liver X receptor reduces proliferation of human oral cancer cells by promoting cholesterol efflux via up-regulation of ABCA1 expression Oncotarget 2015 6(32):33345-57 PubMed ID: 26452260 DOI: 10.18632/oncotarget.5428

15042 Koyama T, Ogawara K, Kasamatsu A, Okamoto A, Kasama H, Minakawa Y, Shimada K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. ANGPTL3 is a novel biomarker as it activates ERK/MAPK pathway in oral cancer Cancer Med 2015 4(5):759-69 PubMed ID: 25644496 DOI: 10.1002/cam4.418

16010 Fukumoto C, Nakashima D, Kasamatsu A, Unozawa M, Shida-Sakazume T, Higo M, Ogawara K, Yokoe H, Shiiba M, Tanzawa H, Uzawa K. WWP2 is overexpressed in human oral cancer, determining tumor size and poor prognosis in patients: downregulation of WWP2 inhibits the AKT signaling and tumor growth in mice Oncoscience 2014 1(12):807-20 PubMed ID: 25621296 DOI: 10.18632/oncoscience.101

5028 Saito Y, Kasamatsu A, Yamamoto A, Shimizu T, Yokoe H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. ALY as a potential contributor to metastasis in human oral squamous cell carcinoma. J Cancer Res Clin Oncol 2013 139(4):585-94 PubMed ID: 23242234 DOI: 10.1007/s00432-012-1361-5

6067 Koike K, Kasamatsu A, Iyoda M, Saito Y, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Tanzawa H, Uzawa K. High prevalence of epigenetic inactivation of the human four and a half LIM domains 1 gene in human oral cancer. Int J Oncol 2013 42(1):141-50 PubMed ID: 23123766 DOI: 10.3892/ijo.2012.1677

6070 Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013 139(4):533-42 PubMed ID: 23207790 DOI: 10.1007/s00432-012-1356-2

6072 Uchida F, Uzawa K, Kasamatsu A, Takatori H, Sakamoto Y, Ogawara K, Shiiba M, Bukawa H, Tanzawa H. Overexpression of CDCA2 in human squamous cell carcinoma: correlation with prevention of G1 phase arrest and apoptosis. PLoS One 2013 8(2):e56381 PubMed ID: 23418564 DOI: 10.1371/journal.pone.0056381

6074 Shimizu F1, Shiiba M2, Ogawara K3, Kimura R1, Minakawa Y1, Baba T1, Yokota S, Nakashima D1, Higo M3, Kasamatsu A3, Sakamoto Y3, Tanzawa H4, Uzawa K4. Overexpression of LIM and SH3 Protein 1 leading to accelerated G2/M phase transition contributes to enhanced tumourigenesis in oral cancer. PLoS One 2013 8(12):e83187 PubMed ID: 24386158 DOI: 10.1371/journal.pone.0083187

6076 Minakawa Y, Kasamatsu A, Koike H, Higo M, Nakashima D, Kouzu Y, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Kinesin family member 4A: a potential predictor for progression of human oral cancer. PLoS One. 2 2013 8(12):e85951 PubMed ID: 24386490 DOI: 10.1371/journal.pone.0085951

6077 Mikami T, Hada T, Chosa N, Ishisaki A, Mizuki H, Takeda Y. Author information Expression of Wilms' tumor 1 (WT1) in oral squamous cell carcinoma. J Oral Pathol Med 2013 42(2):133-9 PubMed ID: 22672247 DOI: 10.1111/j.1600-0714.2012.01182.x

6081 Kimura R, Kasamatsu A, Koyama T, Fukumoto C, Kouzu Y, Higo M, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation. BMC Cancer 2013 13:555 PubMed ID: 24261884 DOI: 10.1186/1471-2407-13-555

6083 Kumai T, Matsuda Y, Oikawa K, Aoki N, Kimura S, Harabuchi Y, Celis E, Kobayashi H. EGFR inhibitors augment antitumour helper T-cell responses of HER family-specific immunotherapy. Br J Cancer 2013 109(8):2155-66 PubMed ID: 24045666 DOI: 10.1038/bjc.2013.577

6110 YOSHIAKI TABUCHI, YUKIHIRO FURUSAWA, SHIGEHITO WADA, KENZO OHTSUKA, TAKASHI KONDO Silencing Heat Shock Transcription Factor 1 Using Small Interfering RNA Enhances Mild Hyperthermia and Hyperthermia Sensitivity in Human Oral Squamous Cell Carcinoma Cells Thermal Medicine 2011 27:99-108 DOI: 10.3191/thermalmed.27.99

8284 Suzuki K, Sakiyama Y, Usui M, Obama T, Kato R, Itabe H, Yamamoto M. Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. J. Periodont. Res. 2010 45:488-95 PubMed ID: 20412422 DOI: 10.1111/j.1600-0765.2009.01263.x

6120 Furuta H, Kondo Y, Nakahata S, Hamasaki M, Sakoda S, Morishita K. NDRG2 is a candidate tumor-suppressor for oral squamous-cell carcinoma. Biochem Biophys Res Commun 2010 391(4):1785-91 PubMed ID: 20045673 DOI: 10.1016/j.bbrc.2009.12.156

6122 Nomi N, Kodama S, Suzuki M. Toll-like receptor 3 signaling induces apoptosis in human head and neck cancer via survivin associated pathway. Oncol Rep 2010 24(1):225-31 PubMed ID: 20514466 DOI: 10.3892/or_00000850

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x