| 利用者成果(英) |
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21175
Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L.
Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors.
Signal Transduct Target Ther
2023
8(1):153
PubMed ID: 37041169
DOI: 10.1038/s41392-023-01359-x
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21231
Saito Y, Takahashi T, Hiramatsu K, Serada S, Fujimoto M, Ohkawara T, Sugase T, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Ishii KJ, Eguchi H, Doki Y, Naka T.
Nano-particulate Toll-like Receptor 9 Agonist Potentiates the Antitumor Activity of Anti-Glypican-1 Antibody.
Anticancer Res
2023
43(6):2425-2432
PubMed ID: 37247902
DOI: 10.21873/anticanres.16410
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20614
Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O.
Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.
Biochem Biophys Rep
2022
30:101246
PubMed ID: 35330672
DOI: 10.1016/j.bbrep.2022.101246
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20247
Munekage E, Serada S, Tsujii S, Yokota K, Kiuchi K, Tominaga K, Fujimoto M, Kanda M, Uemura S, Namikawa T, Nomura T, Murakami I, Hanazaki K, Naka T.
A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.
Neoplasia
2021
23(9):939-950
PubMed ID: 34332450
DOI: 10.1016/j.neo.2021.07.006
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20413
Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl JA, Nakagawa H.
Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy.
Biomolecules
2021
11(10)
PubMed ID: 34680112
DOI: 10.3390/biom11101479
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16116
Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y.
APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation
Br J Cancer
2021
125(11):1523-1532
PubMed ID: 34599296
DOI: 10.1038/s41416-021-01561-0
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12111
Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y.
GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab.
Elife
2020
PubMed ID: 32228854
DOI: 10.7554/eLife.49392
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11583
Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH.
PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.
Cancer Lett.
2019
PubMed ID: 31173854
DOI: 10.1016/j.canlet.2019.05.040
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11791
Shin WS, Lee HW, Lee ST.
Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF.
FASEB J.
2019
PubMed ID: 31490704
DOI: 10.1096/fj.201900932R
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11897
Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W.
Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.
Nat Commun
2019
PubMed ID: 31700061
DOI: 10.1038/s41467-019-12846-7
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11699
Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.
Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer.
Cancer Sci
2019
110(6):1863-1871
PubMed ID: 31012515
DOI: 10.1111/cas.14028
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12594
Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.
Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer
Cancer Sci
2019
110(12):3727-3737
PubMed ID: 31599475
DOI: 10.1111/cas.14214
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10798
Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.
Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.
Oncogene
2018
37(26):3471-3484
PubMed ID: 29563607
DOI: 10.1038/s41388-018-0179-2
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11092
Shin WS, Gim J, Won S, Lee ST.
Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma.
Sci Rep
2018
8(1):8519
PubMed ID: 29867084
DOI: 10.1038/s41598-018-26957-6
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4355
Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.
PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.
Cancer Sci.
2018
109(2):412-421
PubMed ID: 29168598
DOI: 10.1111/cas.13454
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4358
Lim KS, Mimura K, Kua LF, Shiraishi K, Kono K.
Implication of Highly Cytotoxic Natural Killer Cells for Esophageal Squamous Cell Carcinoma Treatment.
J. Immunother.
2018
41(6):261-273
PubMed ID: 29683892
DOI: 10.1097/CJI.0000000000000227
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9448
Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii
p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4
Cancer Res
2018
78(21):6107-6120
PubMed ID: 30181180
DOI: 10.1158/0008-5472.CAN-18-1749
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10141
Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.
Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.
Int. J. Cancer
2017
140:2608-2621
PubMed ID: 28233302
DOI: 10.1002/ijc.30666
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10353
Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.
Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.
Tumour Biol.
2017
39:1010428317700409
PubMed ID: 28618928
DOI: 10.1177/1010428317700409
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14217
Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.
SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma
Cancer Res
2017
77(24):6975-6986
PubMed ID: 29042418
DOI: 10.1158/0008-5472.CAN-17-1525
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14228
Fujita Y, Masuda K, Hamada J, Shoda K, Naruto T, Hamada S, Miyakami Y, Kohmoto T, Watanabe M, Takahashi R, Tange S, Saito M, Kudo Y, Fujiwara H, Ichikawa D, Tangoku A, Otsuji E, Imoto I.
KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression
Oncotarget
2017
;8(60):101130-101145.
PubMed ID: 29254151
DOI: 10.18632/oncotarget.20926
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14559
Sci Rep
MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin
2017
7(1):10932
PubMed ID: 28883406
DOI: 10.1038/s41598-017-10977-9
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14630
Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.
Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma
Oncotarget
2017
8(15):24741-24752
PubMed ID: 28445969
DOI: 10.18632/oncotarget.15799
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9724
Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.
Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.
Br. J. Cancer
2016
115:66-75
PubMed ID: 27310703
DOI: 10.1038/bjc.2016.183
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12618
Kosumi K, Baba Y, Sakamoto A, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H.
Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer
Int J Cancer
2016
138(2):428-39
PubMed ID: 26240060
DOI: 10.1002/ijc.29714
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12664
Shin WS, Hong Y, Lee HW, Lee ST.
Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells
Oncotarget
2016
7(45):73242-73256
PubMed ID: 27689325
DOI: 10.18632/oncotarget.12303
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12969
Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I.
Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma
Oncotarget
2016
7(13):17111-28
PubMed ID: 26958940
DOI: 10.18632/oncotarget.7937
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13992
Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H.
UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma
Oncotarget
2016
7(36):57821-5783
PubMed ID: 27507047
DOI: 10.18632/oncotarget.11067
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14119
Park M, Yoon HJ, Kang MC, Kwon J, Lee HW.
PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma
Tumour Biol
2016
37(10):14217-14224
PubMed ID: 27557627
DOI: 10.1007/s13277-016-5288-3
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7382
Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.
The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.
BMC Cancer
2015
15:82
PubMed ID: 25884729
DOI: 10.1186/s12885-015-1065-8
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14284
Bill A, Gutierrez A, Kulkarni S, Kemp C, Bonenfant D, Voshol H, Duvvuri U, Gaither LA.
ANO1/TMEM16A interacts with EGFR and correlates with sensitivity to EGFR-targeting therapy in head and neck cancer
Oncotarget
2015
6(11):9173-88
PubMed ID: 25823819
DOI: 10.18632/oncotarget.3277
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15159
Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.
Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers
Proc Natl Acad Sci U S A
2015
112(29):E3816-25
PubMed ID: 26124144
DOI: 10.1073/pnas.1510077112
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15184
Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.
Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom
Anticancer Res
2015
35(9):4617-24
PubMed ID: 26254350
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13765
Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H.
Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer
Cancer Res
2014
74(2):575-85
PubMed ID: 24272485
DOI: 10.1158/0008-5472.CAN-13-1836
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15825
Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment
Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment
Cancer Sci
2014
105(10):1236-44
PubMed ID: 25154680
DOI: 10.1111/cas.12503
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17149
Yeo SY, Ha SY, Yu EJ, Lee KW, Kim JH, Kim SH.
ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, pr
Oncotarget
2014
5(23):12260-72
PubMed ID: 25373738
DOI: 10.18632/oncotarget.2630
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6410
Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.
Is parainfluenza virus a threatening virus for human cancer cell lines?
Hum Cell
2009
22(3):81-4
PubMed ID: 19624309
DOI: 10.1111/j.1749-0774.2009.00071.x
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