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Cell No. : Cell Name
RCB2101 : TE-14  update : 2022/09/16
CommentHuman cell line derived from esophageal cancer. Moderately differentiated squamous cell carcinoma. TKG0265 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditions1) In publishing the research results to be obtained by use of this cell line, an acknowledgment to the Depositor, Dr. Tetsuro Nishihira is required. 2) There is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Nishihira, Tetsuro
Year of deposit 2005
Original cell TKG0265
Animal human < Mammals
Genus Homo
Species sapiens
Gender Male
Age at sampling 57 years
Tissue esophagus
Disease name Moderately differntiated squamous carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0265)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_3336
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
Culture information Passage ratio 1 : 2-4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 0
User's Publication 34


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Reference

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User's Publication
20614  Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O.  Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer.  Biochem Biophys Rep  2022  30:101246  PubMed ID: 35330672   DOI: 10.1016/j.bbrep.2022.101246
20247  Munekage E, Serada S, Tsujii S, Yokota K, Kiuchi K, Tominaga K, Fujimoto M, Kanda M, Uemura S, Namikawa T, Nomura T, Murakami I, Hanazaki K, Naka T.  A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma.  Neoplasia  2021  23(9):939-950  PubMed ID: 34332450   DOI: 10.1016/j.neo.2021.07.006
20413  Shimonosono M, Tanaka K, Flashner S, Takada S, Matsuura N, Tomita Y, Sachdeva UM, Noguchi E, Sangwan V, Ferri L, Momen-Heravi F, Yoon AJ, Klein-Szanto AJ, Diehl JA, Nakagawa H.  Alcohol Metabolism Enriches Squamous Cell Carcinoma Cancer Stem Cells That Survive Oxidative Stress via Autophagy.  Biomolecules  2021  11(10)  PubMed ID: 34680112   DOI: 10.3390/biom11101479
16116  Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y.  APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation  Br J Cancer  2021  125(11):1523-1532  PubMed ID: 34599296   DOI: 10.1038/s41416-021-01561-0
12111  Kato D, Yaguchi T, Iwata T, Katoh Y, Morii K, Tsubota K, Takise Y, Tamiya M, Kamada H, Akiba H, Tsumoto K, Serada S, Naka T, Nishimura R, Nakagawa T, Kawakami Y.  GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab.  Elife  2020    PubMed ID: 32228854   DOI: 10.7554/eLife.49392
11583  Shi JJ, Xing H, Wang YX, Zhang X, Zhan QM, Geng MY, Ding J, Meng LH.  PI3Kα inhibitors sensitize esophageal squamous cell carcinoma to radiation by abrogating survival signals in tumor cells and tumor microenvironment.  Cancer Lett.  2019    PubMed ID: 31173854   DOI: 10.1016/j.canlet.2019.05.040
11791  Shin WS, Lee HW, Lee ST.  Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF.  FASEB J.  2019    PubMed ID: 31490704   DOI: 10.1096/fj.201900932R
11897  Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W.  Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma.  Nat Commun  2019    PubMed ID: 31700061   DOI: 10.1038/s41467-019-12846-7
11699  Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer.  Cancer Sci  2019  110(6):1863-1871  PubMed ID: 31012515   DOI: 10.1111/cas.14028
12594  Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H.  Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer  Cancer Sci  2019  110(12):3727-3737  PubMed ID: 31599475   DOI: 10.1111/cas.14214
10798  Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A.  Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug.  Oncogene  2018  37(26):3471-3484  PubMed ID: 29563607   DOI: 10.1038/s41388-018-0179-2
11092  Shin WS, Gim J, Won S, Lee ST.  Biphasic regulation of tumorigenesis by PTK7 expression level in esophageal squamous cell carcinoma.  Sci Rep  2018  8(1):8519  PubMed ID: 29867084   DOI: 10.1038/s41598-018-26957-6
4355  Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y.  PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation.  Cancer Sci.  2018  109(2):412-421  PubMed ID: 29168598   DOI: 10.1111/cas.13454
4358  Lim KS, Mimura K, Kua LF, Shiraishi K, Kono K.  Implication of Highly Cytotoxic Natural Killer Cells for Esophageal Squamous Cell Carcinoma Treatment.  J. Immunother.  2018  41(6):261-273  PubMed ID: 29683892   DOI: 10.1097/CJI.0000000000000227
9448  Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii  p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4  Cancer Res  2018  78(21):6107-6120  PubMed ID: 30181180   DOI: 10.1158/0008-5472.CAN-18-1749
10141  Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T.  Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice.  Int. J. Cancer  2017  140:2608-2621  PubMed ID: 28233302   DOI: 10.1002/ijc.30666
10353  Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma.  Tumour Biol.  2017  39:1010428317700409  PubMed ID: 28618928   DOI: 10.1177/1010428317700409
14217  Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T.  SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma  Cancer Res  2017  77(24):6975-6986  PubMed ID: 29042418   DOI: 10.1158/0008-5472.CAN-17-1525
14228  Fujita Y, Masuda K, Hamada J, Shoda K, Naruto T, Hamada S, Miyakami Y, Kohmoto T, Watanabe M, Takahashi R, Tange S, Saito M, Kudo Y, Fujiwara H, Ichikawa D, Tangoku A, Otsuji E, Imoto I.  KH-type splicing regulatory protein is involved in esophageal squamous cell carcinoma progression  Oncotarget   2017  ;8(60):101130-101145.  PubMed ID: 29254151   DOI: 10.18632/oncotarget.20926
14559  Sci Rep  MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin    2017  7(1):10932  PubMed ID: 28883406   DOI: 10.1038/s41598-017-10977-9
14630  Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T.  Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma  Oncotarget  2017  8(15):24741-24752  PubMed ID: 28445969   DOI: 10.18632/oncotarget.15799
9724  Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T.  Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma.  Br. J. Cancer  2016  115:66-75  PubMed ID: 27310703   DOI: 10.1038/bjc.2016.183
12618  Kosumi K, Baba Y, Sakamoto A, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H.  Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer  Int J Cancer  2016  138(2):428-39  PubMed ID: 26240060   DOI: 10.1002/ijc.29714
12664  Shin WS, Hong Y, Lee HW, Lee ST.  Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells  Oncotarget  2016  7(45):73242-73256  PubMed ID: 27689325   DOI: 10.18632/oncotarget.12303
12969  Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I.  Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma  Oncotarget  2016  7(13):17111-28  PubMed ID: 26958940   DOI: 10.18632/oncotarget.7937
13992  Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H.  UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma  Oncotarget  2016  7(36):57821-5783  PubMed ID: 27507047   DOI: 10.18632/oncotarget.11067
14119  Park M, Yoon HJ, Kang MC, Kwon J, Lee HW.  PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma  Tumour Biol  2016  37(10):14217-14224  PubMed ID: 27557627   DOI: 10.1007/s13277-016-5288-3
7382  Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T.  The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma.  BMC Cancer  2015  15:82  PubMed ID: 25884729   DOI: 10.1186/s12885-015-1065-8
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
15184  Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H.  Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom  Anticancer Res  2015  35(9):4617-24  PubMed ID: 26254350  
13765  Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H.  Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer  Cancer Res  2014  74(2):575-85  PubMed ID: 24272485   DOI: 10.1158/0008-5472.CAN-13-1836
15825  Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment  Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment  Cancer Sci  2014  105(10):1236-44  PubMed ID: 25154680   DOI: 10.1111/cas.12503
17149  Yeo SY, Ha SY, Yu EJ, Lee KW, Kim JH, Kim SH.  ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, pr  Oncotarget  2014  5(23):12260-72  PubMed ID: 25373738   DOI: 10.18632/oncotarget.2630
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x



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