CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2098 : TE-8]

21691 Kobayashi T, Noma K, Nishimura S, Kato T, Nishiwaki N, Ohara T, Kunitomo T, Kawasaki K, Akai M, Komoto S, Kashima H, Kikuchi S, Tazawa H, Shirakawa Y, Choyke PL, Kobayashi H, Fujiwara T. Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts using a Humanized anti-Fibroblast Activation Protein Antibody. Mol Cancer Ther 2024 PubMed ID: 38638034 DOI: 10.1158/1535-7163.MCT-23-0527

21907 Sasamori R, Sato Y, Nomura K, Wakita A, Nagaki Y, Kemuriyama K, Sasaki Y, Nozaki S, Takahashi T, Terata K, Imai K, Minamiya Y. Lipopolysaccharide induces CCL2 through TLR4 signaling and promotes esophageal squamous cell carcinoma cell proliferation. Am J Cancer Res 2024 14(7):3497-3512 PubMed ID: 39113860 DOI: 10.62347/EIKE6128

22398 Harino T, Tanaka K, Motooka D, Masuike Y, Takahashi T, Yamashita K, Saito T, Yamamoto K, Makino T, Kurokawa Y, Nakajima K, Eguchi H, Doki Y. D-loop mutations in mitochondrial DNA are a risk factor for chemotherapy resistance in esophageal cancer. Sci Rep 2024 14(1):31653 PubMed ID: 39738117 DOI: 10.1038/s41598-024-80226-3

22436 Sasaki Y, Sato Y, Nomura K, Wakita A, Nagaki Y, Sasamori R, Yoneya T, Takahashi T, Yamada M, Takahashi M, Terata K, Imai K. Peptidoglycan induces CXCL10 production and inhibits esophageal squamous cell carcinoma proliferation. Am J Cancer Res 2024 14(12):5874-5884 PubMed ID: 39803645 DOI: 10.62347/NHPV3701

22489 Horino T, Horiguchi H, Yumoto S, Kadomatsu T, Hara Y, Yagi T, Baba Y, Miyamoto Y, Baba H, Oike Y. Angiopoietin-Like Protein 2 Expression in Tumor Cells Supports Tumor-Associated Macrophage-Induced Tumor Progression in Esophageal Cancer Ann Surg Oncol 2024 31(12):7693-7704 PubMed ID: 38981990 DOI: 10.1245/s10434-024-15557-6

19698 Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Nishibeppu K, Kamiya H, Arakawa H, Ishida R, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Fujiwara H, Otsuji E. Plasma miR-1254 as a predictive biomarker of chemosensitivity and a target of nucleic acid therapy in esophageal cancer Cancer Sci 2023 114(7):3027-3040 PubMed ID: 37190912 DOI: 10.1111/cas.15830

19967 Kawasaki K, Noma K, Kato T, Ohara T, Tanabe S, Takeda Y, Matsumoto H, Nishimura S, Kunitomo T, Akai M, Kobayashi T, Nishiwaki N, Kashima H, Maeda N, Kikuchi S, Tazawa H, Shirakawa Y, Fujiwara T. PD-L1-expressing cancer-associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer Cancer Immunol Immunother 2023 72(11):3787-3802 PubMed ID: 37668710 DOI: 10.1007/s00262-023-03531-2

21077 Ishibashi Y, Mochizuki S, Horiuchi K, Tsujimoto H, Kouzu K, Kishi Y, Okada Y, Ueno H. Periostin derived from cancer-associated fibroblasts promotes esophageal squamous cell carcinoma progression via ADAM17 activation. Biochim Biophys Acta Mol Basis Dis 2023 1869(5):166669 PubMed ID: 36813090 DOI: 10.1016/j.bbadis.2023.166669

21175 Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L. Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors. Signal Transduct Target Ther 2023 8(1):153 PubMed ID: 37041169 DOI: 10.1038/s41392-023-01359-x

21406 Nguyen Vu TH, Kikuchi O, Ohashi S, Saito T, Ida T, Nakai Y, Cao Y, Yamamoto Y, Kondo Y, Mitani Y, Kataoka S, Kondo T, Katada C, Yamada A, Matsubara J, Muto M. Combination therapy with WEE1 inhibition and trifluridine/tipiracil against esophageal squamous cell carcinoma. Cancer Sci 2023 PubMed ID: 37724648 DOI: 10.1111/cas.15966

21444 Yamada M, Tanaka K, Yamamoto K, Matsumoto H, Yamasaki M, Yamashita K, Makino T, Saito T, Yamamoto K, Takahashi T, Kurokawa Y, Nakajima K, Okada Y, Eguchi H, Doki Y. Association between circ_0004365 and cisplatin resistance in esophageal squamous cell carcinoma. Oncol Lett 2023 26(5):467 PubMed ID: 37780544 DOI: 10.3892/ol.2023.14054

17547 Shimizu H, Katsurahara K, Inoue H, Shiozaki A, Kosuga T, Kudou M, Arita T, Konishi H, Komatsu S, Fujiwara H, Morinaga Y, Konishi E, Otsuji E. NADPH Oxidase 2 Has a Crucial Role in Cell Cycle Progression of Esophageal Squamous Cell Carcinoma Ann Surg Oncol 2022 29(13):8677-8687 PubMed ID: 35972670 DOI: 10.1245/s10434-022-12384-5

17598 Kim S, Kim GH, Park SJ, Kwon CH, I H, Lee MW, Lee BE. Exosomal MicroRNA Analyses in Esophageal Squamous Cell Carcinoma Cell Lines J Clin Med 2022 11(15):4426 PubMed ID: 35956043 DOI: 10.3390/jcm11154426

17626 Nomoto D, Baba Y, Liu Y, Tsutsuki H, Okadome K, Harada K, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Moroishi T, Komohara Y, Sawa T, Baba H. Fusobacterium nucleatum promotes esophageal squamous cell carcinoma progression via the NOD1/RIPK2/NF-κB pathway Cancer Lett 2022 530:59-67 PubMed ID: 35033591 DOI: 10.1016/j.canlet.2022.01.014

20614 Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O. Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer. Biochem Biophys Rep 2022 30:101246 PubMed ID: 35330672 DOI: 10.1016/j.bbrep.2022.101246

22670 Sato H, Noma K, Ohara T, Kawasaki K, Akai M, Kobayashi T, Nishiwaki N, Narusaka T, Komoto S, Kashima H, Katsura Y, Kato T, Kikuchi S, Tazawa H, Kagawa S, Shirakawa Y, Kobayashi H, Fujiwara T. Dual-targeted near-infrared photoimmunotherapy for esophageal cancer and cancer-associated fibroblasts in the tumor microenvironment Sci Rep 2022 12(1):20152 PubMed ID: 36418422 DOI: 10.1038/s41598-022-24313-3

13104 Yoshida T, Yokobori T, Saito H, Kuriyama K, Kumakura Y, Honjo H, Hara K, Sakai M, Miyazaki T, Obinata H, Erkhem-Ochir B, Gombodorj N, Sohda M, Saeki H, Kuwano H, Shirabe K. CD36 Expression Is Associated with Cancer Aggressiveness and Energy Source in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 2021 PubMed ID: 32529269 DOI: 10.1245/s10434-020-08711-3

13383 Sakamoto H, Koma YI, Higashino N, Kodama T, Tanigawa K, Shimizu M, Fujikawa M, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H. PAI-1 derived from cancer-associated fibroblasts in esophageal squamous cell carcinoma promotes the invasion of cancer cells and the migration of macrophages. Lab Invest 2021 101(3):353-368 PubMed ID: 33311557 DOI: 10.1038/s41374-020-00512-2

20015 Fujikawa M, Koma YI, Hosono M, Urakawa N, Tanigawa K, Shimizu M, Kodama T, Sakamoto H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H. Chemokine (C-C Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. Am J Pathol 2021 PubMed ID: 33460563 DOI: 10.1016/j.ajpath.2021.01.004

20046 Mitsuda M, Shiozaki A, Kudou M, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 2021 PubMed ID: 33565032 DOI: 10.1245/s10434-021-09659-8

20069 Narusaka T, Ohara T, Noma K, Nishiwaki N, Katsura Y, Kato T, Sato H, Tomono Y, Kikuchi S, Tazawa H, Shirakawa Y, Matsukawa A, Fujiwara T. Nanog is a promising chemo-resistant stemness marker and therapeutic target by iron chelators for esophageal cancer. Int J Cancer 2021 PubMed ID: 33662150 DOI: 10.1002/ijc.33544

20071 Matsumoto Y, Shiozaki A, Kosuga T, Kudou M, Shimizu H, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E. Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma. Ann Surg Oncol 2021 PubMed ID: 33710504 DOI: 10.1245/s10434-021-09752-y

20247 Munekage E, Serada S, Tsujii S, Yokota K, Kiuchi K, Tominaga K, Fujimoto M, Kanda M, Uemura S, Namikawa T, Nomura T, Murakami I, Hanazaki K, Naka T. A glypican-1-targeted antibody-drug conjugate exhibits potent tumor growth inhibition in glypican-1-positive pancreatic cancer and esophageal squamous cell carcinoma. Neoplasia 2021 23(9):939-950 PubMed ID: 34332450 DOI: 10.1016/j.neo.2021.07.006

16095 Liu Y, Baba Y, Ishimoto T, Tsutsuki H, Zhang T, Nomoto D, Okadome K, Yamamura K, Harada K, Eto K, Hiyoshi Y, Iwatsuki M, Nagai Y, Iwagami S, Miyamoto Y, Yoshida N, Komohara Y, Ohmuraya M, Wang X, Ajani JA, Sawa T, Baba H. Fusobacterium nucleatum confers chemoresistance by modulating autophagy in oesophageal squamous cell carcinoma Br J Cancer 2021 124(5):963-974 PubMed ID: 33299132 DOI: 10.1038/s41416-020-01198-5

16116 Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y. APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation Br J Cancer 2021 125(11):1523-1532 PubMed ID: 34599296 DOI: 10.1038/s41416-021-01561-0

16130 Yajima S, Sugawara K, Iwai M, Tanaka M, Seto Y, Todo T. Efficacy and safety of a third-generation oncolytic herpes virus G47Δ in models of human esophageal carcinoma Mol Ther Oncolytics 2021 ;23:402-411 PubMed ID: 34853811 DOI: 10.1016/j.omto.2021.10.012

16863 Takaki W, Konishi H, Shoda K, Arita T, Kataoka S, Shibamoto J, Furuke H, Takabatake K, Shimizu H, Komatsu S, Shiozaki A, Fujiwara H, Masuda K, Otsuji E. Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma Ann Surg Oncol 2021 28(13):8508-8518 PubMed ID: 34185205 DOI: 10.1245/s10434-021-10089-9

12107 Matsubara D, Konishi H, Arita T, Shoda K, Fujita Y, Ogino S, Takao K, Nanishi K, Kosuga T, Komatsu S, Shiozaki A, Fujiwara H, Okamoto K, Otsuji E. Involvement of Intracellular and Extracellular High-Mobility Group Box-1 in the Progression of Esophageal Squamous Cell Carcinoma. Ann. Surg. Oncol. 2020 PubMed ID: 32221734 DOI: 10.1245/s10434-020-08363-3

13045 Kodama T, Koma YI, Arai N, Kido A, Urakawa N, Nishio M, Shigeoka M, Yokozaki H. CCL3-CCR5 axis contributes to progression of esophageal squamous cell carcinoma by promoting cell migration and invasion via Akt and ERK pathways. Lab Invest 2020 PubMed ID: 32457351 DOI: 10.1038/s41374-020-0441-4

13609 Okamoto M, Koma YI, Kodama T, Nishio M, Shigeoka M, Yokozaki H. Growth Differentiation Factor 15 Promotes Progression of Esophageal Squamous Cell Carcinoma via TGF-β Type II Receptor Activation Pathobiology 2020 87(2):100-113 PubMed ID: 31896114 DOI: 10.1159/000504394

11491 Shafaee A, Pirayesh Islamian J, Zarei D, Mohammadi M, Nejati-Koshki K, Farajollahi A, Aghamiri SMR, Rahmati Yamchi M, Baradaran B, Asghari Jafarabadi M. Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism. Iran J Med Sci 2019 PubMed ID: 30936596

11432 Kodaira H, Koma YI, Hosono M, Higashino N, Suemune K, Nishio M, Shigeoka M, Yokozaki H. ANXA10 induction by interaction with tumor-associated macrophages promotes the growth of esophageal squamous cell carcinoma. Pathol. Int. 2019 PubMed ID: 30758105 DOI: 10.1111/pin.12771

11631 Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E. LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. Am. J. Pathol. 2019 PubMed ID: 31323188 DOI: 10.1016/j.ajpath.2019.06.006

11897 Su D, Zhang D, Jin J, Ying L, Han M, Chen K, Li B, Wu J, Xie Z, Zhang F, Lin Y, Cheng G, Li JY, Huang M, Wang J, Wang K, Zhang J, Li F, Xiong L, Futreal A, Mao W. Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma. Nat Commun 2019 PubMed ID: 31700061 DOI: 10.1038/s41467-019-12846-7

12594 Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H. Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer Cancer Sci 2019 110(12):3727-3737 PubMed ID: 31599475 DOI: 10.1111/cas.14214

12596 Son SW, Chau GC, Kim ST, Um SH. Vacuolar H +-ATPase Subunit V0C Regulates Aerobic Glycolysis of Esophageal Cancer Cells via PKM2 Signaling Cells 2019 8(10):1137 PubMed ID: 31554233 DOI: 10.3390/cells8101137

10255 Shiozaki A, Kudou M, Ichikawa D, Fujiwara H, Shimizu H, Ishimoto T, Arita T, Kosuga T, Konishi H, Komatsu S, Okamoto K, Marunaka Y, Otsuji E. Esophageal cancer stem cells are suppressed by tranilast, a TRPV2 channel inhibitor. J. Gastroenterol. 2018 53:197-207 PubMed ID: 28389731 DOI: 10.1007/s00535-017-1338-x

10734 Wei L, Yan N, Sun L, Bao C, Li D. Interplay between the NF‑κB and hedgehog signaling pathways predicts prognosis in esophageal squamous cell carcinoma following neoadjuvant chemoradiotherapy. Int. J. Mol. Med. 2018 41:2961-2967 PubMed ID: 29393402 DOI: 10.3892/ijmm.2018.3447

10755 Masuike Y, Tanaka K, Makino T, Yamasaki M, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Mori M, Doki Y. Esophageal squamous cell carcinoma with low mitochondrial copy number has mesenchymal and stem-like characteristics, and contributes to poor prognosis. PLoS ONE 2018 13:e0193159 PubMed ID: 29447301 DOI: 10.1371/journal.pone.0193159

10798 Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A. Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug. Oncogene 2018 37(26):3471-3484 PubMed ID: 29563607 DOI: 10.1038/s41388-018-0179-2

11229 Hemmatzadeh M, Mohammadi H, Babaie F, Yousefi M, Ebrazeh M, Mansoori B, Shanehbandi D, Baradaran B. Snail-1 Silencing by siRNA Inhibits Migration of TE-8 Esophageal Cancer Cells Through Downregulation of Metastasis-Related Genes. Adv Pharm Bull 2018 PubMed ID: 30276140 DOI: 10.15171/apb.2018.051

4355 Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation. Cancer Sci. 2018 109(2):412-421 PubMed ID: 29168598 DOI: 10.1111/cas.13454

4356 Ishibashi O, Akagi I, Ogawa Y, Inui T. MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway. Biochem Biophys Res Commun. 2018 501(2):507-513 PubMed ID: 29738771 DOI: 10.1016/j.bbrc.2018.05.025

4357 Kim MJ, Choi SK, Hong SH, Eun JW, Nam SW, Han JW, You JS. Oncogenic IL7R is downregulated by histone deacetylase inhibitor in esophageal squamous cell carcinoma via modulation of acetylated FOXO1. Int. J. Oncol. 2018 53(1):395-403 PubMed ID: 29749437 DOI: 10.3892/ijo.2018.4392

4504 Piao L, Yang Z, Jin J, Ni W, Qi W, Xuan Y. B7H4 is associated with stemness and cancer progression in esophageal squamous cell carcinoma. Hum. Pathol. 2018 80:152-162 PubMed ID: 29885401 DOI: 10.1016/j.humpath.2018.05.021

4505 Yang Z, Ni W, Cui C, Qi W, Piao L, Xuan Y. Identification of LETM1 as a marker of cancer stem-like cells and predictor of poor prognosis in esophageal squamous cell carcinoma. Hum. Pathol. 2018 81:148-156 PubMed ID: 30031102 DOI: 10.1016/j.humpath.2018.07.001

9448 Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4 Cancer Res 2018 78(21):6107-6120 PubMed ID: 30181180 DOI: 10.1158/0008-5472.CAN-18-1749

14921 Lee TS, Song IH, Shin JI, Park YS, Kim JY, Kim KI, Lee YJ, Kang JH. PET Imaging Biomarkers of Anti-EGFR Immunotherapy in Esophageal Squamous Cell Carcinoma Models Cells 2018 7(11):187 PubMed ID: 30373221 DOI: 10.3390/cells7110187

9998 Hijiya N, Shibata T, Daa T, Hamanaka R, Uchida T, Matsuura K, Tsukamoto Y, Nakada C, Iha H, Inomata M, Moriyama M. Overexpression of cannabinoid receptor 1 in esophageal squamous cell carcinoma is correlated with metastasis to lymph nodes and distant organs, and poor prognosis. Pathol. Int. 2017 67:83-90 PubMed ID: 27976824 DOI: 10.1111/pin.12495

10004 Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K. Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. Int. J. Oncol. 2017 50:441-447 PubMed ID: 28035351 DOI: 10.3892/ijo.2016.3817

10116 Akagi I, Ishibashi O. RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium. Genom Data 2017 12:4-6 PubMed ID: 28224081 DOI: 10.1016/j.gdata.2017.02.002

10141 Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T. Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. Int. J. Cancer 2017 140:2608-2621 PubMed ID: 28233302 DOI: 10.1002/ijc.30666

10213 Hara K, Miyazaki T, Yokobori T, Yoshida T, Kumakura Y, Honjyo H, Sakai M, Sohda M, Fukuchi M, Kuwano H. Significance and Function of MicroRNA-7 in Oesophageal Squamous Cell Carcinoma. Anticancer Res. 2017 37:1043-1048 PubMed ID: 28314263 DOI: 10.21873/anticanres.11415

10353 Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E. Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma. Tumour Biol. 2017 39:1010428317700409 PubMed ID: 28618928 DOI: 10.1177/1010428317700409

10365 Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. Oncol Lett 2017 14:1581-1587 PubMed ID: 28789382 DOI: 10.3892/ol.2017.6334

10449 Yoshioka M, Ohashi S, Ida T, Nakai Y, Kikuchi O, Amanuma Y, Matsubara J, Yamada A, Miyamoto S, Natsuizaka M, Nakagawa H, Chiba T, Seno H, Muto M. Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells. J. Exp. Clin. Cancer Res. 2017 36:101 PubMed ID: 28764725 DOI: 10.1186/s13046-017-0572-7

10561 Li Z, Jin H, Mao G, Wu L, Guo Q. Msi2 plays a carcinogenic role in esophageal squamous cell carcinoma via regulation of the Wnt/β-catenin and Hedgehog signaling pathways. Exp. Cell Res. 2017 361:170-177 PubMed ID: 29054489 DOI: 10.1016/j.yexcr.2017.10.016

10692 Hosono M, Koma YI, Takase N, Urakawa N, Higashino N, Suemune K, Kodaira H, Nishio M, Shigeoka M, Kakeji Y, Yokozaki H. CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells. Oncotarget 2017 8:106071-106088 PubMed ID: 29285315 DOI: 10.18632/oncotarget.22526

10954 IM Puspitasari, R Abdulah, M Syamsunarno, H Koyama Effect of different doses of X-ray irradiation on survival of human esophageal cells Advances in Biomolecular Medicine 2017 53 DOI: 10.1201/9781315208619-13

10977 Role of HDM2 Gene in Radio-Sensitivity of Esophageal Cancer Cell Lines to Irradiation Int J Cancer Manag 2017 10:e8950 DOI: 10.5812/ijcm.8950

14217 Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T. SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma Cancer Res 2017 77(24):6975-6986 PubMed ID: 29042418 DOI: 10.1158/0008-5472.CAN-17-1525

14243 Shiozaki A, Kudou M, Ichikawa D, Shimizu H, Arita T, Kosuga T, Konishi H, Komatsu S, Fujiwara H, Okamoto K, Kishimoto M, Marunaka Y, Otsuji E. Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma Oncotarget 2017 8(11):17921-17935 PubMed ID: 28160546 DOI: 10.18632/oncotarget.14900

14626 Kumakura Y, Rokudai S, Iijima M, Altan B, Yoshida T, Bao H, Yokobori T, Sakai M, Sohda M, Miyazaki T, Nishiyama M, Kuwano H. Elevated expression of ΔNp63 in advanced esophageal squamous cell carcinoma Cancer Sci 2017 108(11):2149-2155 PubMed ID: 28892579 DOI: 10.1111/cas.13394

14630 Harada E, Serada S, Fujimoto M, Takahashi Y, Takahashi T, Hara H, Nakatsuka R, Sugase T, Nishigaki T, Saito Y, Hiramatsu K, Nojima S, Mitsuo R, Ohkawara T, Morii E, Mori M, Doki Y, Kaneda Y, Naka T. Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma Oncotarget 2017 8(15):24741-24752 PubMed ID: 28445969 DOI: 10.18632/oncotarget.15799

14646 Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S. Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma Oncotarget 2017 8(4):6353-6363 PubMed ID: 28031525 DOI: 10.18632/oncotarget.14087

14654 Hadisaputri YE, Miyazaki T, Yokobori T, Sohda M, Sakai M, Ozawa D, Hara K, Honjo H, Kumakura Y, Kuwano H. TNFAIP3 overexpression is an independent factor for poor survival in esophageal squamous cell carcinoma Int J Oncol 2017 50(3):1002-1010 PubMed ID: 28197630 DOI: 10.3892/ijo.2017.3869

14743 Osako Y, Seki N, Koshizuka K, Okato A, Idichi T, Arai T, Omoto I, Sasaki K, Uchikado Y, Kita Y, Kurahara H, Maemura K, Natsugoe S. Regulation of SPOCK1 by dual strands of pre-miR-150 inhibit cancer cell migration and invasion in esophageal squamous cell carcinoma J Hum Genet 2017 62(11):935-944 PubMed ID: 28659612 DOI: 10.1038/jhg.2017.69

9599 Kikuchi O, Ohashi S, Horibe T, Kohno M, Nakai Y, Miyamoto S, Chiba T, Muto M, Kawakami K. Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma. Sci Rep 2016 6:22452 PubMed ID: 26956916 DOI: 10.1038/srep22452

9656 Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y. Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma. Oncology 2016 90:347-55 PubMed ID: 27082627 DOI: 10.1159/000445323

9724 Hara H, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Nakatsuka R, Harada E, Nishigaki T, Takahashi Y, Nojima S, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Miyata H, Nakajima K, Takiguchi S, Morii E, Mori M, Doki Y, Naka T. Overexpression of glypican-1 implicates poor prognosis and their chemoresistance in oesophageal squamous cell carcinoma. Br. J. Cancer 2016 115:66-75 PubMed ID: 27310703 DOI: 10.1038/bjc.2016.183

19409 Son SW, Kim SH, Moon EY, Kim DH, Pyo S, Um SH. Prognostic significance and function of the vacuolar H+-ATPase subunit V1E1 in esophageal squamous cell carcinoma Oncotarget 2016 7(31):49334-49348 PubMed ID: 27384996 DOI: 10.18632/oncotarget.10340

12663 Song IH, Lee TS, Park YS, Lee JS, Lee BC, Moon BS, An GI, Lee HW, Kim KI, Lee YJ, Kang JH, Lim SM. Immuno-PET Imaging and Radioimmunotherapy of 64Cu-/177Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model J Nucl Med 2016 57(7):1105-11 PubMed ID: 26917708 DOI: 10.2967/jnumed.115.167155

12903 Nishio M, Urakawa N, Shigeoka M, Takase N, Ichihara Y, Arai N, Koma Y, Yokozaki H. Software-assisted morphometric and phenotype analyses of human peripheral blood monocyte-derived macrophages induced by a microenvironment model of human esophageal squamous cell carcinoma Pathol Int 2016 66(2):83-93 PubMed ID: 26778807 DOI: 10.1111/pin.12381

12969 Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I. Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma Oncotarget 2016 7(13):17111-28 PubMed ID: 26958940 DOI: 10.18632/oncotarget.7937

13973 Takase N, Koma Y, Urakawa N, Nishio M, Arai N, Akiyama H, Shigeoka M, Kakeji Y, Yokozaki H. NCAM- and FGF-2-mediated FGFR1 signaling in the tumor microenvironment of esophageal cancer regulates the survival and migration of tumor-associated macrophages and cancer cells Cancer Lett 2016 380(1):47-58 PubMed ID: 27317650 DOI: 10.1016/j.canlet.2016.06.009

13992 Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H. UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma Oncotarget 2016 7(36):57821-5783 PubMed ID: 27507047 DOI: 10.18632/oncotarget.11067

13993 Pirayesh Islamian J, Mohammadi M, Baradaran B, Farajollahi A, Aghamiri SM, Asghari Jafarabadi M, Karami H, Monfaredan A, Shanehbandi D. Enhancing radiosensitivity of TE1, TE8, and TE 11 esophageal squamous carcinoma cell lines by Hdm2-siRNA targeted gene therapy in vitro Bioimpacts 2016 6(2):93-8 PubMed ID: 27525226 DOI: 10.15171/bi.2016.13

14108 Osako Y, Seki N, Kita Y, Yonemori K, Koshizuka K, Kurozumi A, Omoto I, Sasaki K, Uchikado Y, Kurahara H, Maemura K, Natsugoe S. Regulation of MMP13 by antitumor microRNA-375 markedly inhibits cancer cell migration and invasion in esophageal squamous cell carcinoma Int J Oncol 2016 49(6):2255-2264 PubMed ID: 27779648 DOI: 10.3892/ijo.2016.3745

14118 Lee HW, Kwon J, Kang MC, Noh MK, Koh JS, Kim JH, Park JH. Overexpression of HSP47 in esophageal squamous cell carcinoma: clinical implications and functional analysis Dis Esophagus 2016 29(7):848-855 PubMed ID: 25953518 DOI: 10.1111/dote.12359

14119 Park M, Yoon HJ, Kang MC, Kwon J, Lee HW. PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma Tumour Biol 2016 37(10):14217-14224 PubMed ID: 27557627 DOI: 10.1007/s13277-016-5288-3

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7382 Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T. The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. BMC Cancer 2015 15:82 PubMed ID: 25884729 DOI: 10.1186/s12885-015-1065-8

15151 Yokobori T, Bao P, Fukuchi M, Altan B, Ozawa D, Rokudai S, Bai T, Kumakura Y, Honjo H, Hara K, Sakai M, Sohda M, Miyazaki T, Ide M, Nishiyama M, Oyama T, Kuwano H. Nuclear PROX1 is Associated with Hypoxia-Inducible Factor 1α Expression and Cancer Progression in Esophageal Squamous Cell Carcinoma Ann Surg Oncol 2015 22 Suppl 3:S1566-73 PubMed ID: 26310281 DOI: 10.1245/s10434-015-4831-6

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15184 Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H. Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom Anticancer Res 2015 35(9):4617-24 PubMed ID: 26254350

15226 Matsushita D, Uenosono Y, Arigami T, Yanagita S, Nishizono Y, Hagihara T, Hirata M, Haraguchi N, Arima H, Kijima Y, Kurahara H, Maemura K, Okumura H, Ishigami S, Natsugoe S. Clinical Significance of Circulating Tumor Cells in Peripheral Blood of Patients with Esophageal Squamous Cell Carcinoma Ann Surg Oncol 2015 22(11):3674-80 PubMed ID: 25652049 DOI: 10.1245/s10434-015-4392-8

15229 Shigeoka M, Urakawa N, Nishio M, Takase N, Utsunomiya S, Akiyama H, Kakeji Y, Komori T, Koma Y, Yokozaki H. Cyr61 promotes CD204 expression and the migration of macrophages via MEK/ERK pathway in esophageal squamous cell carcinoma Cancer Med 2015 4(3):437-46 PubMed ID: 25620088 DOI: 10.1002/cam4.401

15232 Urakawa N, Utsunomiya S, Nishio M, Shigeoka M, Takase N, Arai N, Kakeji Y, Koma Y, Yokozaki H. GDF15 derived from both tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression via Akt and Erk pathways Lab Invest 2015 95(5):491-503 PubMed ID: 25730371 DOI: 10.1038/labinvest.2015.36

19049 Kwon J, Yoon HJ, Kim JH, Lee TS, Song IH, Lee HW, Kang MC, Park JH. Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma Oncol Rep 2014 32(3):1188-92 PubMed ID: 24993015 DOI: 10.3892/or.2014.3302

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13765 Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H. Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer Cancer Res 2014 74(2):575-85 PubMed ID: 24272485 DOI: 10.1158/0008-5472.CAN-13-1836

15822 Ohashi S, Kikuchi O, Tsurumaki M, Nakai Y, Kasai H, Horimatsu T, Miyamoto S, Shimizu A, Chiba T, Muto M. Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma PLoS One 2014 9(8):e103126 PubMed ID: 25090101 DOI: 10.1371/journal.pone.0103126

16011 Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, Chen S, Wang Q, Shen X, Xue R, Dong L. Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma Oncotarget 2014 5(16):7183-97 PubMed ID: 25216531 DOI: 10.18632/oncotarget.2293

17132 Ichiro Akagi, Osamu Ishibashi, Takeshi Matsutani, Nobutoshi Hagiwara, Akihisa Matsuda, Tsutomu Nomura, Hiroshi Makino, Hiroshi Yoshida, Masao Miyashita, Eiji Uchida Comprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets Dataset Papers in Science 2014 1-3:2014-12-15 DOI: 10.1155/2014/376541

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19438 Kwon J, Lee TS, Lee HW, Kang MC, Yoon HJ, Kim JH, Park JH. Integrin alpha 6: a novel therapeutic target in esophageal squamous cell carcinoma Int J Oncol 2013 43(5):1523-30 PubMed ID: 24042193 DOI: 10.3892/ijo.2013.2097

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