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								22975 
								Shimote K, Niinuma T, Kitajima H, Ishiguro K, Yamamoto E, Sudo G, Yorozu A, Toyota M, Kai M, Idogawa M, Suzuki H. 
								Upregulation of LINC02154 promotes esophageal cancer progression by enhancing cell cycling and epithelial-mesenchymal transition. 
								Noncoding RNA Res 
								2025 
								14:107-116 
								
									
										PubMed ID: 40529228
									
								 
								
									
										DOI: 10.1016/j.ncrna.2025.06.001
									
								
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								23210 
								Nakajima S, Saito K, Fukai S, Sakuma M, Matsuishi A, Kanoda R, Maruyama Y, Suzuki H, Okayama H, Saito M, Mimura K, Nirei A, Kikuchi T, Hanayama H, Saze Z, Momma T, Nishiyama K, Suzutani T, Kono K. 
								Activation of the tumor cell-intrinsic STING pathway induced by Fusobacterium nucleatum is associated with poor prognosis in esophageal cancer patients. 
								Esophagus 
								2025 
								22(2):239-249 
								
									
										PubMed ID: 39951185
									
								 
								
									
										DOI: 10.1007/s10388-025-01112-z
									
								
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								23281 
								Tanaka H, Maruyama S, Shoda K, Kawaguchi Y, Higuchi Y, Ozawa T, Nakayama T, Saito R, Izumo W, Takiguchi K, Shiraishi K, Furuya S, Amemiya H, Kawaida H, Ichikawa D. 
								miR‑100‑5p and miR‑203a‑3p suppress esophageal squamous cell carcinoma progression by targeting FKBP5. 
								Oncol Rep 
								2025 
								54(6):10.3892/or.2025.9003 
								
									
										PubMed ID: 41041863
									
								 
								
									
										DOI: 10.3892/or.2025.9003
									
								
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								23346 
								Hirose K, Otsu H, Masuda T, Saeki H, Tobo T, Hosoda K, Matsumoto C, Tatsumi T, Ikehara T, Ofuchi T, Higuchi S, Abe T, Nakano Y, Hashimoto M, Nakanoko T, Oki E, Yoshizumi T, Mimori K. 
								Cytotoxic Anti-tumor Drugs and Tumor-Associated Macrophages Synergistically Surge PD-L1 Expression in Esophageal Squamous Cell Carcinoma 
								Ann Surg Oncol 
								2025 
								32(10):7860-7873. 
								
									
										PubMed ID: 40619486
									
								 
								
									
										DOI: 10.1245/s10434-025-17710-1
									
								
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								21175 
								Zhang X, Wang Y, Zhang X, Shen Y, Yang K, Ma Q, Qiao Y, Shi J, Wang Y, Xu L, Yang B, Ge G, Hu L, Kong X, Yang C, Chen Y, Ding J, Meng L. 
								Intact regulation of G1/S transition renders esophageal squamous cell carcinoma sensitive to PI3Kα inhibitors. 
								Signal Transduct Target Ther 
								2023 
								8(1):153 
								
									
										PubMed ID: 37041169
									
								 
								
									
										DOI: 10.1038/s41392-023-01359-x
									
								
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								16142 
								Dong X, Chen X, Lu D, Diao D, Liu X, Mai S, Feng S, Xiong G. 
								LncRNA miR205HG hinders HNRNPA0 translation: anti-oncogenic effects in esophageal carcinoma 
								Mol Oncol  
								2022 
								16(3):795-812 
								
									
										PubMed ID: 34821009
									
								 
								
									
										DOI: 10.1002/1878-0261.13142
									
								
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								20614 
								Tsuchihashi K, Hirata Y, Yamasaki J, Suina K, Tanoue K, Yae T, Masuda K, Baba E, Akashi K, Kitagawa Y, Saya H, Nagano O. 
								Presence of spontaneous epithelial-mesenchymal plasticity in esophageal cancer. 
								Biochem Biophys Rep 
								2022 
								30:101246 
								
									
										PubMed ID: 35330672
									
								 
								
									
										DOI: 10.1016/j.bbrep.2022.101246
									
								
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								20682 
								Masuda T, Tazawa H, Hashimoto Y, Ieda T, Kikuchi S, Kuroda S, Noma K, Urata Y, Kagawa S, Fujiwara T. 
								Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells. 
								Acta Med Okayama 
								2022 
								76(2):203-215 
								
									
										PubMed ID: 35503449
									
								 
								
									
										DOI: 10.18926/AMO/63425
									
								
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								16116 
								Kobayashi T, Makino T, Yamashita K, Saito T, Tanaka K, Takahashi T, Kurokawa Y, Yamasaki M, Nakajima K, Morii E, Eguchi H, Doki Y. 
								APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation 
								Br J Cancer 
								2021 
								125(11):1523-1532 
								
									
										PubMed ID: 34599296
									
								 
								
									
										DOI: 10.1038/s41416-021-01561-0
									
								
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								6883 
								Terayama M, Yamada K, Hagiwara T, Inazuka F, Sezaki T, Igari T, Yokoi C, Nohara K, Soma D, Dohi T, Kawamura Y. 
								Glutathione S-transferase omega 2 regulates cell growth and the expression of E-cadherin via post-transcriptional downregulation of β-catenin in human esophageal squamous cells. 
								Carcinogenesis 
								2020 
								41(7):875-886 
								
									
										PubMed ID: 31738399
									
								 
								
									
										DOI: 10.1093/carcin/bgz189
									
								
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								13600 
								Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K. 
								p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers 
								Biochem Biophys Res Commun 
								2020 
								529(3):582-589. 
								
									
										PubMed ID: 32736677
									
								 
								
									
										DOI: 10.1016/j.bbrc.2020.05.168
									
								
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								11511 
								Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. 
								Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens. 
								Nature 
								2019 
								 
								
									
										PubMed ID: 30971826
									
								 
								
									
										DOI: 10.1038/s41586-019-1103-9
									
								
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								11631 
								Konishi T, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E. 
								LRRC8A Expression Influences Growth of Esophageal Squamous Cell Carcinoma. 
								Am. J. Pathol. 
								2019 
								 
								
									
										PubMed ID: 31323188
									
								 
								
									
										DOI: 10.1016/j.ajpath.2019.06.006
									
								
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								11699 
								Kiyozumi Y, Baba Y, Okadome K, Yagi T, Ogata Y, Eto K, Hiyoshi Y, Ishimoto T, Iwatsuki M, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H. 
								Indoleamine 2, 3-dioxygenase 1 promoter hypomethylation is associated with poor prognosis in patients with esophageal cancer. 
								Cancer Sci 
								2019 
								110(6):1863-1871 
								
									
										PubMed ID: 31012515
									
								 
								
									
										DOI: 10.1111/cas.14028
									
								
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								12594 
								Kalikawe R, Baba Y, Nomoto D, Okadome K, Miyake K, Eto K, Hiyoshi Y, Nagai Y, Iwatsuki M, Ishimoto T, Iwagami S, Miyamoto Y, Yoshida N, Watanabe M, Baba H. 
								Lysyl oxidase impacts disease outcomes and correlates with global DNA hypomethylation in esophageal cancer 
								Cancer Sci 
								2019 
								110(12):3727-3737 
								
									
										PubMed ID: 31599475
									
								 
								
									
										DOI: 10.1111/cas.14214
									
								
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								12595 
								Sawayama H, Ogata Y, Ishimoto T, Mima K, Hiyoshi Y, Iwatsuki M, Baba Y, Miyamoto Y, Yoshida N, Baba H. 
								Glucose transporter 1 regulates the proliferation and cisplatin sensitivity of esophageal cancer 
								Cancer Sci  
								2019 
								110(5):1705-1714 
								
									
										PubMed ID: 30861255
									
								 
								
									
										DOI: 10.1111/cas.13995
									
								
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								10798 
								Shinno N, Kimura H, Sada R, Takiguchi S, Mori M, Fumoto K, Doki Y, Kikuchi A. 
								Activation of the Dickkopf1-CKAP4 pathway is associated with poor prognosis of esophageal cancer and anti-CKAP4 antibody may be a new therapeutic drug. 
								Oncogene 
								2018 
								37(26):3471-3484 
								
									
										PubMed ID: 29563607
									
								 
								
									
										DOI: 10.1038/s41388-018-0179-2
									
								
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								11088 
								Thomenius MJ, Totman J, Harvey D, Mitchell LH, Riera TV, Cosmopoulos K, Grassian AR, Klaus C, Foley M, Admirand EA, Jahic H, Majer C, Wigle T, Jacques SL, Gureasko J, Brach D, Lingaraj T, West K, Smith S, Rioux N, Waters NJ, Tang C, Raimondi A, Munchhof M, Mills JE, Ribich S, Porter Scott M, Kuntz KW, Janzen WP, Moyer M, Smith JJ, Chesworth R, Copeland RA, Boriack-Sjodin PA. 
								Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation. 
								PLoS ONE 
								2018 
								13(6):e0197372 
								
									
										PubMed ID: 29856759
									
								 
								
									
										DOI: 10.1371/journal.pone.0197372
									
								
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								4355 
								Furukawa H, Makino T, Yamasaki M, Tanaka K, Miyazaki Y, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. 
								PRIMA-1 induces p53-mediated apoptosis by upregulating Noxa in esophageal squamous cell carcinoma with TP53 missense mutation. 
								Cancer Sci. 
								2018 
								109(2):412-421 
								
									
										PubMed ID: 29168598
									
								 
								
									
										DOI: 10.1111/cas.13454
									
								
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								9448 
								Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchii 
								p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4 
								Cancer Res 
								2018 
								78(21):6107-6120 
								
									
										PubMed ID: 30181180
									
								 
								
									
										DOI: 10.1158/0008-5472.CAN-18-1749
									
								
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								14921 
								Lee TS, Song IH, Shin JI, Park YS, Kim JY, Kim KI, Lee YJ, Kang JH. 
								PET Imaging Biomarkers of Anti-EGFR Immunotherapy in Esophageal Squamous Cell Carcinoma Models 
								Cells 
								2018 
								7(11):187 
								
									
										PubMed ID: 30373221
									
								 
								
									
										DOI: 10.3390/cells7110187
									
								
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								10141 
								Sugase T, Takahashi T, Serada S, Nakatsuka R, Fujimoto M, Ohkawara T, Hara H, Nishigaki T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Takiguchi S, Kishimoto T, Mori M, Doki Y, Naka T. 
								Suppressor of cytokine signaling-1 gene therapy induces potent antitumor effect in patient-derived esophageal squamous cell carcinoma xenograft mice. 
								Int. J. Cancer 
								2017 
								140:2608-2621 
								
									
										PubMed ID: 28233302
									
								 
								
									
										DOI: 10.1002/ijc.30666
									
								
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								10353 
								Kawaguchi T, Komatsu S, Ichikawa D, Hirajima S, Nishimura Y, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E. 
								Overexpression of TRIM44 is related to invasive potential and malignant outcomes in esophageal squamous cell carcinoma. 
								Tumour Biol. 
								2017 
								39:1010428317700409 
								
									
										PubMed ID: 28618928
									
								 
								
									
										DOI: 10.1177/1010428317700409
									
								
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								10365 
								Yamamoto M, Yamasaki M, Tsukao Y, Tanaka K, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mori M, Doki Y. 
								Poly (ADP-ribose) polymerase-1 inhibition decreases proliferation through G2/M arrest in esophageal squamous cell carcinoma. 
								Oncol Lett 
								2017 
								14:1581-1587 
								
									
										PubMed ID: 28789382
									
								 
								
									
										DOI: 10.3892/ol.2017.6334
									
								
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								14217 
								Sugase T, Takahashi T, Serada S, Fujimoto M, Hiramatsu K, Ohkawara T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Kishimoto T, Mori M, Doki Y, Naka T. 
								SOCS1 Gene Therapy Improves Radiosensitivity and Enhances Irradiation-Induced DNA Damage in Esophageal Squamous Cell Carcinoma 
								Cancer Res 
								2017 
								77(24):6975-6986 
								
									
										PubMed ID: 29042418
									
								 
								
									
										DOI: 10.1158/0008-5472.CAN-17-1525
									
								
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								14559 
								Sci Rep 
								MiR-338-5p enhances the radiosensitivity of esophageal squamous cell carcinoma by inducing apoptosis through targeting survivin 
								 
								2017 
								7(1):10932 
								
									
										PubMed ID: 28883406
									
								 
								
									
										DOI: 10.1038/s41598-017-10977-9
									
								
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								9656 
								Nakahara Y, Yamasaki M, Sawada G, Miyazaki Y, Makino T, Takahashi T, Kurokawa Y, Nakajima K, Takiguchi S, Mimori K, Mori M, Doki Y. 
								Downregulation of SIRT4 Expression Is Associated with Poor Prognosis in Esophageal Squamous Cell Carcinoma. 
								Oncology 
								2016 
								90:347-55 
								
									
										PubMed ID: 27082627
									
								 
								
									
										DOI: 10.1159/000445323
									
								
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								12618 
								Kosumi K, Baba Y, Sakamoto A, Ishimoto T, Harada K, Nakamura K, Kurashige J, Hiyoshi Y, Iwatsuki M, Iwagami S, Sakamoto Y, Miyamoto Y, Yoshida N, Oki E, Watanabe M, Hino S, Nakao M, Baba H. 
								Lysine-specific demethylase-1 contributes to malignant behavior by regulation of invasive activity and metabolic shift in esophageal cancer 
								Int J Cancer 
								2016 
								138(2):428-39 
								
									
										PubMed ID: 26240060
									
								 
								
									
										DOI: 10.1002/ijc.29714
									
								
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								12663 
								Song IH, Lee TS, Park YS, Lee JS, Lee BC, Moon BS, An GI, Lee HW, Kim KI, Lee YJ, Kang JH, Lim SM. 
								Immuno-PET Imaging and Radioimmunotherapy of 64Cu-/177Lu-Labeled Anti-EGFR Antibody in Esophageal Squamous Cell Carcinoma Model 
								J Nucl Med 
								2016 
								57(7):1105-11 
								
									
										PubMed ID: 26917708
									
								 
								
									
										DOI: 10.2967/jnumed.115.167155
									
								
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								12969 
								Hamada J, Shoda K, Masuda K, Fujita Y, Naruto T, Kohmoto T, Miyakami Y, Watanabe M, Kudo Y, Fujiwara H, Ichikawa D, Otsuji E, Imoto I. 
								Tumor-promoting function and prognostic significance of the RNA-binding protein T-cell intracellular antigen-1 in esophageal squamous cell carcinoma 
								Oncotarget 
								2016 
								7(13):17111-28 
								
									
										PubMed ID: 26958940
									
								 
								
									
										DOI: 10.18632/oncotarget.7937
									
								
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								13992 
								Nakamura K, Baba Y, Kosumi K, Harada K, Shigaki H, Miyake K, Kiyozumi Y, Ohuchi M, Kurashige J, Ishimoto T, Iwatsuki M, Sakamoto Y, Yoshida N, Watanabe M, Nakao M, Baba H. 
								UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma 
								Oncotarget 
								2016 
								7(36):57821-5783 
								
									
										PubMed ID: 27507047
									
								 
								
									
										DOI: 10.18632/oncotarget.11067
									
								
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								14119 
								Park M, Yoon HJ, Kang MC, Kwon J, Lee HW. 
								PTK7 regulates radioresistance through nuclear factor-kappa B in esophageal squamous cell carcinoma 
								Tumour Biol 
								2016 
								37(10):14217-14224 
								
									
										PubMed ID: 27557627
									
								 
								
									
										DOI: 10.1007/s13277-016-5288-3
									
								
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								7382 
								Saito S, Morishima K, Ui T, Hoshino H, Matsubara D, Ishikawa S, Aburatani H, Fukayama M, Hosoya Y, Sata N, Lefor AK, Yasuda Y, Niki T. 
								The role of HGF/MET and FGF/FGFR in fibroblast-derived growth stimulation and lapatinib-resistance of esophageal squamous cell carcinoma. 
								BMC Cancer 
								2015 
								15:82 
								
									
										PubMed ID: 25884729
									
								 
								
									
										DOI: 10.1186/s12885-015-1065-8
									
								
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								15184 
								Harada K, Baba Y, Ishimoto T, Kosumi K, Tokunaga R, Izumi D, Ohuchi M, Nakamura K, Kiyozumi Y, Kurashige J, Iwagami S, Miyamoto Y, Sakamoto Y, Yoshida N, Oki E, Watanabe M, Baba H. 
								Suppressor microRNA-145 Is Epigenetically Regulated by Promoter Hypermethylation in Esophageal Squamous Cell Carcinom 
								Anticancer Res 
								2015 
								35(9):4617-24 
								
									
										PubMed ID: 26254350
									
								 
								
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								15448 
								Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W, Ochiai A. 
								TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer 
								Cancer Med 
								2015 
								4(11):1667-78 
								
									
										PubMed ID: 26336878
									
								 
								
									
										DOI: 10.1002/cam4.515
									
								
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								5608 
								Zhou X, Koizumi Y, Zhang M, Natsui M, Koyota S, Yamada M, Kondo Y, Hamada F, Sugiyama T. 
								Cadmium-coordinated supramolecule suppresses tumor growth of T-cell leukemia in mice 
								Cancer Sci 
								2015 
								106(5):635-41 
								
									
										PubMed ID: 25735932
									
								 
								
									
										DOI: 10.1111/cas.12651
									
								
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								19049 
								Kwon J, Yoon HJ, Kim JH, Lee TS, Song IH, Lee HW, Kang MC, Park JH. 
								Cetuximab inhibits cisplatin-induced activation of EGFR signaling in esophageal squamous cell carcinoma 
								Oncol Rep 
								2014 
								32(3):1188-92 
								
									
										PubMed ID: 24993015
									
								 
								
									
										DOI: 10.3892/or.2014.3302
									
								
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								13765 
								Sawayama H, Ishimoto T, Watanabe M, Yoshida N, Sugihara H, Kurashige J, Hirashima K, Iwatsuki M, Baba Y, Oki E, Morita M, Shiose Y, Baba H. 
								Small molecule agonists of PPAR-γ exert therapeutic effects in esophageal cancer 
								Cancer Res 
								2014 
								74(2):575-85 
								
									
										PubMed ID: 24272485
									
								 
								
									
										DOI: 10.1158/0008-5472.CAN-13-1836
									
								
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								15825 
								Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment 
								Inhibition of mitogen-activated protein kinase pathway can induce upregulation of human leukocyte antigen class I without PD-L1-upregulation in contrast to interferon-γ treatment 
								Cancer Sci 
								2014 
								105(10):1236-44 
								
									
										PubMed ID: 25154680
									
								 
								
									
										DOI: 10.1111/cas.12503
									
								
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								16011 
								Zhang S, Tang W, Weng S, Liu X, Rao B, Gu J, Chen S, Wang Q, Shen X, Xue R, Dong L. 
								Apollon modulates chemosensitivity in human esophageal squamous cell carcinoma 
								Oncotarget 
								2014 
								5(16):7183-97 
								
									
										PubMed ID: 25216531
									
								 
								
									
										DOI: 10.18632/oncotarget.2293
									
								
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								17149 
								Yeo SY, Ha SY, Yu EJ, Lee KW, Kim JH, Kim SH. 
								ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, pr 
								Oncotarget 
								2014 
								5(23):12260-72 
								
									
										PubMed ID: 25373738
									
								 
								
									
										DOI: 10.18632/oncotarget.2630
									
								
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								19438 
								Kwon J, Lee TS, Lee HW, Kang MC, Yoon HJ, Kim JH, Park JH. 
								Integrin alpha 6: a novel therapeutic target in esophageal squamous cell carcinoma 
								Int J Oncol 
								2013 
								43(5):1523-30 
								
									
										PubMed ID: 24042193
									
								 
								
									
										DOI: 10.3892/ijo.2013.2097
									
								
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								6410 
								Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. 
								Is parainfluenza virus a threatening virus for human cancer cell lines? 
								Hum Cell 
								2009 
								22(3):81-4 
								
									
										PubMed ID: 19624309
									
								 
								
									
										DOI: 10.1111/j.1749-0774.2009.00071.x
									
								
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