CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2095 : PANC-1]

3301 Yamada T, Okajima F, Ohwada S, Kondo Y Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. Cell Mol Life Sci 1997 53:435-41 PubMed ID: 9176562 DOI: 10.1007/s000180050052

5077 Wu MC, Arimura GK, Yunis AA. Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int J Cancer 1978 22(6):728-33 PubMed ID: 363626 DOI: 10.1002/ijc.2910220615

3459 Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer 1975 15:741-7 PubMed ID: 1140870 DOI: 10.1002/ijc.2910150505

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19817 Miyata S, Ishii T, Kitanaka S. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia Anticancer Res 2024 44(1):49-59 PubMed ID: 38159998 DOI: 10.21873/anticanres.16787

19848 Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Ishii N, Tsukagoshi M, Watanabe A, Harimoto N, Masamune A, Uojima H, Mizokami M, Ito K, Shirabe K. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer Cancer Sci 2024 Feb 6 PubMed ID: 38321872 DOI: 10.1111/cas.16087

21666 Zhang Z, Aoki H, Umezawa K, Kranrod J, Miyazaki N, Oshima T, Hirao T, Miura Y, Seubert J, Ito K, Aoki S. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discov 2024 10(1):166 PubMed ID: 38580661 DOI: 10.1038/s41420-024-01933-4

21692 Tazuma S, Sudo T, Ishikawa A, Yamaguchi A, Shibata Y, Ishida Y, Kuraoka K, Uemura K, Takahashi S, Tashiro H. Effects of transmembrane serine protease 4 on the survival in patients with pancreatic ductal adenocarcinoma undergoing surgery followed by adjuvant chemotherapy. Surg Today 2024 PubMed ID: 38637344 DOI: 10.1007/s00595-024-02824-y

21722 Zhong P, Nakata K, Oyama K, Higashijima N, Sagara A, Date S, Luo H, Hayashi M, Kubo A, Wu C, He S, Yamamoto T, Koikawa K, Iwamoto C, Abe T, Ikenaga N, Ohuchida K, Morisaki T, Oda Y, Kuba K, Nakamura M. Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells. J Exp Clin Cancer Res 2024 43(1):138 PubMed ID: 38715057 DOI: 10.1186/s13046-024-03060-5

21802 Akimoto T, Islam MR, Nagasako A, Kishi K, Nakakaji R, Ohtake M, Hasumi H, Yamaguchi T, Yamada S, Yamamoto T, Ishikawa Y, Umemura M. Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming. Cancer Sci 2024 PubMed ID: 38877783 DOI: 10.1111/cas.16243

21897 Takata T, Nakamura A, Yasuda H, Miyake H, Sogame Y, Sawai Y, Hayakawa M, Mochizuki K, Nakao R, Ogata T, Ikoma H, Konishi E, Harada Y, Otsuji E, Itoh Y, Tanaka H. Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors Acta Histochem Cytochem 2024 57(2):57-66 PubMed ID: 38695038 DOI: 10.1267/ahc.24-00010

21916 Kiichi Y, Fukuoka K, Kitano A, Ishino K, Kotoku N. Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs Molecules 2024 29(6):1389 PubMed ID: 38543025 DOI: 10.3390/molecules29061389

22062 Terai T, Nishiwada S, Nagai M, Nakamura K, Kohara Y, Yasuda S, Matsuo Y, Doi S, Sakata T, Kumada H, Watanabe M, Sho M. Clinical impact of carbonic anhydrase 9 expression on neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma. Pancreatology 2024 24(6):938-946 PubMed ID: 39152081 DOI: 10.1016/j.pan.2024.08.003

22131 Kawataki S, Kubota Y, Katayama K, Imoto S, Takekawa M. GADD45β-MTK1 signaling axis mediates oncogenic stress-induced activation of the p38 and JNK pathways. Cancer Sci 2024 PubMed ID: 39526327 DOI: 10.1111/cas.16389

18285 Yamakawa K, Koyanagi-Aoi M, Machinaga A, Kakiuchi N, Hirano T, Kodama Y, Aoi T. Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase Cancer Cell Int 2023 23(1):94 PubMed ID: 37198667 DOI: 10.1186/s12935-023-02928-4

19616 Masuo H, Kubota K, Shimizu A, Notake T, Miyazaki S, Yoshizawa T, Sakai H, Hayashi H, Soejima Y. Increased mitochondria are responsible for the acquisition of gemcitabine resistance in pancreatic cancer cell lines Cancer Sci 2023 114(11):4388-4400 PubMed ID: 37700464 DOI: 10.1111/cas.15962

19617 Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K. Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment Cancer Sci 2023 114(11):4286-4298 PubMed ID: 37688308 DOI: 10.1111/cas.15952

19678 Fujihashi Y, Jo Kim M, Maneenet J, Awale S. Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation Chem Biodivers 2023 20(9):e202300280 PubMed ID: 37612242 DOI: 10.1002/cbdv.202300280

19693 Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K. High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer Int J Clin Oncol 2023 28(7):901-912 PubMed ID: 37119370 DOI: 10.1007/s10147-023-02342-w

19793 Tomohara K, Maneenet J, Ohashi N, Nose T, Fujii R, Kim MJ, Sun S, Awale S. Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach Biol Pharm Bull 2023 46(10):1412-1420 PubMed ID: 37779042 DOI: 10.1248/bpb.b23-00224

21009 Doi Y, Wakana D, Kitaoka S, Sato F, Tanaka E, Takeda H, Hosoe T. Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds. J Nat Med 2023 PubMed ID: 36635416 DOI: 10.1007/s11418-022-01673-8

21044 Yamada T, Tateishi R, Iwai M, Tanaka M, Ijichi H, Sano M, Koike K, Todo T. Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors. Mol Ther Oncolytics 2023 28:31-43 PubMed ID: 36619294 DOI: 10.1016/j.omto.2022.12.001

21057 Masuda M, Asuka T, Terao N, Nishino S, Ikeda S, Takamatsu S, Kondo J, Miyoshi E. Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies. J Biochem 2023 PubMed ID: 36760066 DOI: 10.1093/jb/mvad015

21107 Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S. Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model. J Nat Prod 2023 PubMed ID: 36938707 DOI: 10.1021/acs.jnatprod.3c00019

21138 Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Rep Med 2023 PubMed ID: 37003259 DOI: 10.1016/j.xcrm.2023.100960

21177 Ouchida T, Maeda H, Akamatsu Y, Maeda M, Takamatsu S, Kondo J, Misaki R, Kamada Y, Ueda M, Ueda K, Miyoshi E. The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro. Sci Rep 2023 13(1):6175 PubMed ID: 37061516 DOI: 10.1038/s41598-023-28572-6

21197 Ando H, Eshima K, Ishida T. A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest. Eur J Pharmacol 2023 950:175758 PubMed ID: 37121563 DOI: 10.1016/j.ejphar.2023.175758

21234 Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N. Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation. J Med Chem 2023 PubMed ID: 37257133 DOI: 10.1021/acs.jmedchem.3c00394

21257 Fukuda K, Seki N, Yasudome R, Mitsueda R, Asai S, Kato M, Idichi T, Kurahara H, Ohtsuka T. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma. Genes (Basel) 2023 14(5) PubMed ID: 37239355 DOI: 10.3390/genes14050995

21290 Yamashita M, Kumazoe M, Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H. PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Biochem Biophys Res Commun 2023 672:154-160 PubMed ID: 37354608 DOI: 10.1016/j.bbrc.2023.06.043

21299 Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M. Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma. Cancer Res 2023 OF1-OF12 PubMed ID: 37378549 DOI: 10.1158/0008-5472.CAN-22-3762

21412 Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI Insight 2023 PubMed ID: 37733442 DOI: 10.1172/jci.insight.163022

21462 Baba K, Uemura K, Nakazato R, Ijaz F, Takahashi S, Ikegami K. Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells. Med Mol Morphol 2023 PubMed ID: 37930423 DOI: 10.1007/s00795-023-00373-w

21531 Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. J Pharmacol Sci 2023 153(4):232-242 PubMed ID: 37973221 DOI: 10.1016/j.jphs.2023.10.003

21954 Kariya Y, Gu J, Kariya Y. Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit Biomolecules 2023 13(12):1752 PubMed ID: 38136623 DOI: 10.3390/biom13121752

17509 Maneenet J, Tawila AM, Omar AM, Phan ND, Ojima C, Kuroda M, Sato M, Mizoguchi M, Takahashi I, Awale S. Chemical Constituents of Callistemon subulatus and Their Anti-Pancreatic Cancer Activity against Human PANC-1 Cell Line Plants (Basel) 2022 11(19):2466 PubMed ID: 36235333 DOI: 10.3390/plants11192466

17698 Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i> Advances in Microbiology 2022 12:649-670 DOI: 10.4236/aim.2022.1212045

17709 Kimura A, Arai T, Ueno M, Oyama K, Yu H, Yamashita S, Otome Y, Taguchi M. Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis Pharmaceutics 2022 14(11):2400 PubMed ID: 36365217 DOI: 10.3390/pharmaceutics14112400

20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20471 Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M. ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway. Pancreatology 2022 PubMed ID: 34642112 DOI: 10.1016/j.pan.2021.09.012

20558 Kohyama A, Kim MJ, Yokoyama R, Sun S, Omar AM, Phan ND, Meselhy MR, Tsuge K, Awale S, Matsuya Y. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem 2022 54:116563 PubMed ID: 34942553 DOI: 10.1016/j.bmc.2021.116563

16170 Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) ACS Chem Biol 2022 Feb 7. PubMed ID: 35128925 DOI: 10.1021/acschembio.2c00028

20570 Vaes RDW, van Dijk DPJ, Farshadi EA, Olde Damink SWM, Rensen SS, Langen RC. Human pancreatic tumour organoid-derived factors enhance myogenic differentiation. J Cachexia Sarcopenia Muscle 2022 PubMed ID: 35146962 DOI: 10.1002/jcsm.12917

20531 Fujita T, Lin J, Kimishima A, Arai M, Takikawa H, Ogura Y. Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells. Biosci Biotechnol Biochem 2022 PubMed ID: 35157035 DOI: 10.1093/bbb/zbac025

20592 Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M. Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. J Exp Clin Cancer Res 2022 41(1):89 PubMed ID: 35272688 DOI: 10.1186/s13046-022-02301-9

20717 Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T. Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. PLoS One 2022 17(5) PubMed ID: 35617311 DOI: 10.1371/journal.pone.0266620

16760 Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J. Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy Cancer Sci 2022 113(2):576-586 PubMed ID: 34808019 DOI: 10.1111/cas.15209

20774 Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M. Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun 2022 13(1):4063 PubMed ID: 35831322 DOI: 10.1038/s41467-022-31690-w

16849 Nguyen Ngoc Thanh Luan, Takuya Okada, Ruka Arata, Lanke Prudhvi, Moe Miyaguchi, Yuri Kodama, Suresh Awale, Naoki Toyooka Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy Tetrahedron 2022 132931 DOI: 10.1016/j.tet.2022.132931

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20858 Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, Fang L, Seubert JM, Ito K, Aoki S. PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells. Biochem Biophys Res Commun 2022 625:167-173 PubMed ID: 35963163 DOI: 10.1016/j.bbrc.2022.08.004

20976 Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H. Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer 2022 PubMed ID: 36536047 DOI: 10.1038/s41416-022-02106-9

18117 Chao D, Ariake K, Sato S, Ohtsuka H, Takadate T, Ishida M, Masuda K, Maeda S, Miura T, Mitachi K, Yu XJ, Fujishima F, Mizuma M, Nakagawa K, Morikawa T, Kamei T, Unno M. Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer Oncol Rep 2021 45(6):90 PubMed ID: 33846782 DOI: 10.3892/or.2021.8041

13280 Labib PL, Yaghini E, Davidson BR, MacRobert AJ, Pereira SP. 5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies. Transl Oncol 2021 PubMed ID: 33059124 DOI: 10.1016/j.tranon.2020.100886

13355 Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M. Impact of Capicua on Pancreatic Cancer Progression. Ann Surg Oncol 2021 28(6):3198-3207 PubMed ID: 33216264 DOI: 10.1245/s10434-020-09339-z

20018 Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K. The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model. J Surg Res 2021 261:351-360 PubMed ID: 33493887 DOI: 10.1016/j.jss.2020.12.046

20025 Sun S, Kim MJ, Dibwe DF, Omar AM, Athikomkulchai S, Phrutivorapongkul A, Okada T, Tsuge K, Toyooka N, Awale S. Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora. Plants (Basel) 2021 10(2) PubMed ID: 33503922 DOI: 10.3390/plants10020229

20035 Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E. Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. Glycoconj J 2021 38(1):45-54 PubMed ID: 33523362 DOI: 10.1007/s10719-020-09970-8

20094 Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S. Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. Fitoterapia 2021 104901 PubMed ID: 33794305 DOI: 10.1016/j.fitote.2021.104901

20096 Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M. Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential. Pathobiology 2021 1-9 PubMed ID: 33794543 DOI: 10.1159/000514593

20099 Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H. Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells. Anticancer Res 2021 41(4):1733-1744 PubMed ID: 33813377 DOI: 10.21873/anticanres.14938

20164 Sagara A, Nakata K, Yamashita T, Guan W, Zhong P, Matsumoto S, Endo S, Iwamoto C, Shindo K, Ikenaga N, Moriyama T, Ohuchida K, Mizumoto K, Nakamura M. New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth. Pancreatology 2021 PubMed ID: 33965328 DOI: 10.1016/j.pan.2021.04.002

20167 Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N. Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential. Pancreatology 2021 21(3):573-580 PubMed ID: 33541781 DOI: 10.1016/j.pan.2021.01.013

20186 Saito R, Kawaida H, Hosomura N, Amemiya H, Itakura J, Yamamoto A, Takiguchi K, Maruyama S, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Inoue S, Kono H, Ichikawa D. Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression. Ann Surg Oncol 2021 PubMed ID: 34101067 DOI: 10.1245/s10434-021-10250-4

20189 Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer. Int J Radiat Oncol Biol Phys 2021 PubMed ID: 34112559 DOI: 10.1016/j.ijrobp.2021.04.001

14512 Ando H, Eshima K, Ishida T. Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model Biol Pharm Bull 2021 4(2):266-270 PubMed ID: 33518679 DOI: 10.1248/bpb.b20-00825

20254 Sun S, Kim MJ, Omar AM, Duy Phan N, Aoike M, Awale S. GDP Induces PANC-1 Human Pancreatic Cancer Cell Death Preferentially under Nutrient Starvation by Inhibiting PI3K/Akt/mTOR/Autophagy Signaling Pathway. Chem Biodivers 2021 PubMed ID: 34213070 DOI: 10.1002/cbdv.202100389

15289 Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K. Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms J Nat Med 2021 75(3):612-622 PubMed ID: 33813664 DOI: 10.1007/s11418-021-01507-z

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20431 Shiozaki A, Konishi T, Kosuga T, Kudou M, Kurashima K, Inoue H, Shoda K, Arita T, Konishi H, Morimura R, Komatsu S, Ikoma H, Toma A, Kubota T, Fujiwara H, Okamoto K, Otsuji E. Roles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells. Int J Oncol 2021 59(4) PubMed ID: 34414448 DOI: 10.3892/ijo.2021.5256

20436 Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Biochem Biophys Res Commun 2021 578:170-176 PubMed ID: 34597914 DOI: 10.1016/j.bbrc.2021.08.054

20448 Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T. Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate. Micromachines (Basel) 2021 12(11) PubMed ID: 34832842 DOI: 10.3390/mi12111431

16171 Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion Elife 2021 10:e66721 PubMed ID: 34590580 DOI: 10.7554/eLife.66721

16214 PRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI, TAKAO OHTSUKA Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma Anticancer Res 2021 41(10):4821-4836 PubMed ID: 34593431 DOI: 10.21873/anticanres.15297

16522 Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H. Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth ACS Chem Biol 2021 16(8):1576-1586 PubMed ID: 34296611 DOI: 10.1021/acschembio.1c00480

16701 Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly J Cell Biol 2021 220(2):e202006085 PubMed ID: 33443571 DOI: 10.1083/jcb.202006085

16776 Sijia Sun, Min Jo Kim, Ashraf M. Omar, Nguyen Duy Phan, Suresh Awale (+)-Panduratin A induces PANC-1 human pancreatic cancer cell death preferentially under nutrient starvation by inhibiting PI3K/Akt/mTOR/autophagy signaling pathway Phytomedicine Plus 2021 1:100101 DOI: 10.1016/j.phyplu.2021.100101

16777 Liang C, Fukuda T, Isaji T, Duan C, Song W, Wang Y, Gu J. α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma Biochim Biophys Acta Gen Subj 2021 1865(6):12987 PubMed ID: 33571582 DOI: 10.1016/j.bbagen.2021.129870

16778 Jinno N, Yoshida M, Hayashi K, Naitoh I, Hori Y, Natsume M, Kato A, Kachi K, Asano G, Atsuta N, Sahashi H, Kataoka H. Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer Cancer Sci 2021 112(2):668-678 PubMed ID: 33053268 DOI: 10.1111/cas.14689

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19227 Hirai K, Watanabe S, Nishijima N, Shibata K, Hase A, Yamanaka T, Inazu M. Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells Int J Mol Sci 2020 21(15):5190 PubMed ID: 32707889 DOI: 10.3390/ijms21155190

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19318 Atsumi S, Katoh H, Komura D, Hashimoto I, Furuya G, Koda H, Konishi H, Suzuki R, Yamamoto A, Yuba S, Abe H, Rino Y, Oshima T, Ushiku T, Fukayama M, Seto Y, Ishikawa S. Focal adhesion ribonucleoprotein complex proteins are major humoral cancer antigens and targets in autoimmune diseases Commun Biol 2020 3(1):58 PubMed ID: 33067514 DOI: 10.1038/s42003-020-01305-5

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9820 Mai T T Nguyen, Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Suresh Awale 1, Nhan T Nguyen Calosides A-F, Cardenolides From Calotropis gigantea and Their Cytotoxic Activity J Nat Prod 2020 83(2):385-391 PubMed ID: 31967821 DOI: 10.1021/acs.jnatprod.9b00875

11920 Takumi Chinen , Shohei Yamamoto, Yutaka Takeda , Koki Watanabe, Kanako Kuroki , Kaho Hashimoto , Daisuke Takao , Daiju Kitagawa NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells EMBO J 2020 PubMed ID: 31782546 DOI: 10.15252/embj.2019102378

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22121 Matsuda A, Kuno A, Yoshida M, Wagatsuma T, Sato T, Miyagishi M, Zhao J, Suematsu M, Kabe Y, Narimatsu H. Comparative Glycomic Analysis of Exosome Subpopulations Derived from Pancreatic Cancer Cell Lines J Proteome Res 2020 19(6):2516-2524 PubMed ID: 32338917 DOI: 10.1021/acs.jproteome.0c00200

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11811 Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) 2019 11(9):1372 PubMed ID: 31527446 DOI: 10.3390/cancers11091372

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10053 Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN. Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents. Biomater Sci 2017 5:432-443 PubMed ID: 28059418 DOI: 10.1039/c6bm00621c

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14225 Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H. PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma Sci Rep 2017 7(1):1917. PubMed ID: 28507327 DOI: 10.1038/s41598-017-02162-9

14244 Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S. Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma Oncotarget 2017 8(32):53180-53193 PubMed ID: 28881803 DOI: 10.18632/oncotarget.18261

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14655 Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion Cancer Res 2017 77(9):2328-2338 PubMed ID: 28202517 DOI: 10.1158/0008-5472.CAN-16-1846

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