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Cell No. : Cell Name
RCB2095 : PANC-1  update : 2024/09/19
CommentHuman cell line derived from pancreatic cancer. Ductal origin. TKG0606 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2005
Original cell TKG0606
Animal _human < Mammals
Genus Homo
Species sapiens
Gender Unknown
Tissue pancreas
Disease name Pancreaticcarcinoma of ductal origin
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0606)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0480
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
Images
deposit info
lot info
Reference information Reference 3
User's Publication 207


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Reference
3301  Yamada T, Okajima F, Ohwada S, Kondo Y  Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions.  Cell Mol Life Sci  1997  53:435-41  PubMed ID: 9176562   DOI: 10.1007/s000180050052
5077  Wu MC, Arimura GK, Yunis AA.  Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase.  Int J Cancer  1978  22(6):728-33  PubMed ID: 363626   DOI: 10.1002/ijc.2910220615
3459  Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G  Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.  Int J Cancer  1975  15:741-7  PubMed ID: 1140870   DOI: 10.1002/ijc.2910150505

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User's Publication
19817  Miyata S, Ishii T, Kitanaka S.  Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia  Anticancer Res  2024  44(1):49-59  PubMed ID: 38159998   DOI: 10.21873/anticanres.16787
19848  Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Ishii N, Tsukagoshi M, Watanabe A, Harimoto N, Masamune A, Uojima H, Mizokami M, Ito K, Shirabe K.  Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer  Cancer Sci  2024  Feb 6  PubMed ID: 38321872   DOI: 10.1111/cas.16087
21666  Zhang Z, Aoki H, Umezawa K, Kranrod J, Miyazaki N, Oshima T, Hirao T, Miura Y, Seubert J, Ito K, Aoki S.  Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells.  Cell Death Discov  2024  10(1):166  PubMed ID: 38580661   DOI: 10.1038/s41420-024-01933-4
21692  Tazuma S, Sudo T, Ishikawa A, Yamaguchi A, Shibata Y, Ishida Y, Kuraoka K, Uemura K, Takahashi S, Tashiro H.  Effects of transmembrane serine protease 4 on the survival in patients with pancreatic ductal adenocarcinoma undergoing surgery followed by adjuvant chemotherapy.  Surg Today  2024    PubMed ID: 38637344   DOI: 10.1007/s00595-024-02824-y
21722  Zhong P, Nakata K, Oyama K, Higashijima N, Sagara A, Date S, Luo H, Hayashi M, Kubo A, Wu C, He S, Yamamoto T, Koikawa K, Iwamoto C, Abe T, Ikenaga N, Ohuchida K, Morisaki T, Oda Y, Kuba K, Nakamura M.  Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells.  J Exp Clin Cancer Res  2024  43(1):138  PubMed ID: 38715057   DOI: 10.1186/s13046-024-03060-5
21802  Akimoto T, Islam MR, Nagasako A, Kishi K, Nakakaji R, Ohtake M, Hasumi H, Yamaguchi T, Yamada S, Yamamoto T, Ishikawa Y, Umemura M.  Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming.  Cancer Sci  2024    PubMed ID: 38877783   DOI: 10.1111/cas.16243
21897  Takata T, Nakamura A, Yasuda H, Miyake H, Sogame Y, Sawai Y, Hayakawa M, Mochizuki K, Nakao R, Ogata T, Ikoma H, Konishi E, Harada Y, Otsuji E, Itoh Y, Tanaka H.  Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors  Acta Histochem Cytochem  2024  57(2):57-66  PubMed ID: 38695038   DOI: 10.1267/ahc.24-00010
21916  Kiichi Y, Fukuoka K, Kitano A, Ishino K, Kotoku N.  Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs  Molecules  2024  29(6):1389  PubMed ID: 38543025   DOI: 10.3390/molecules29061389
18285  Yamakawa K, Koyanagi-Aoi M, Machinaga A, Kakiuchi N, Hirano T, Kodama Y, Aoi T.  Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase  Cancer Cell Int  2023  23(1):94  PubMed ID: 37198667   DOI: 10.1186/s12935-023-02928-4
19616  Masuo H, Kubota K, Shimizu A, Notake T, Miyazaki S, Yoshizawa T, Sakai H, Hayashi H, Soejima Y.  Increased mitochondria are responsible for the acquisition of gemcitabine resistance in pancreatic cancer cell lines  Cancer Sci  2023  114(11):4388-4400  PubMed ID: 37700464   DOI: 10.1111/cas.15962
19617  Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K.  Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment  Cancer Sci  2023  114(11):4286-4298  PubMed ID: 37688308   DOI: 10.1111/cas.15952
19678  Fujihashi Y, Jo Kim M, Maneenet J, Awale S.  Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation  Chem Biodivers  2023  20(9):e202300280  PubMed ID: 37612242   DOI: 10.1002/cbdv.202300280
19693  Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K.  High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer  Int J Clin Oncol  2023  28(7):901-912  PubMed ID: 37119370   DOI: 10.1007/s10147-023-02342-w
19793  Tomohara K, Maneenet J, Ohashi N, Nose T, Fujii R, Kim MJ, Sun S, Awale S.  Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach  Biol Pharm Bull  2023  46(10):1412-1420  PubMed ID: 37779042   DOI: 10.1248/bpb.b23-00224
21009  Doi Y, Wakana D, Kitaoka S, Sato F, Tanaka E, Takeda H, Hosoe T.  Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds.  J Nat Med  2023    PubMed ID: 36635416   DOI: 10.1007/s11418-022-01673-8
21044  Yamada T, Tateishi R, Iwai M, Tanaka M, Ijichi H, Sano M, Koike K, Todo T.  Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors.  Mol Ther Oncolytics  2023  28:31-43  PubMed ID: 36619294   DOI: 10.1016/j.omto.2022.12.001
21057  Masuda M, Asuka T, Terao N, Nishino S, Ikeda S, Takamatsu S, Kondo J, Miyoshi E.  Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies.  J Biochem  2023    PubMed ID: 36760066   DOI: 10.1093/jb/mvad015
21107  Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S.  Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model.  J Nat Prod  2023    PubMed ID: 36938707   DOI: 10.1021/acs.jnatprod.3c00019
21138  Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR.  A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy.  Cell Rep Med  2023    PubMed ID: 37003259   DOI: 10.1016/j.xcrm.2023.100960
21177  Ouchida T, Maeda H, Akamatsu Y, Maeda M, Takamatsu S, Kondo J, Misaki R, Kamada Y, Ueda M, Ueda K, Miyoshi E.  The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro.  Sci Rep  2023  13(1):6175  PubMed ID: 37061516   DOI: 10.1038/s41598-023-28572-6
21197  Ando H, Eshima K, Ishida T.  A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest.  Eur J Pharmacol  2023  950:175758  PubMed ID: 37121563   DOI: 10.1016/j.ejphar.2023.175758
21234  Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N.  Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation.  J Med Chem  2023    PubMed ID: 37257133   DOI: 10.1021/acs.jmedchem.3c00394
21257  Fukuda K, Seki N, Yasudome R, Mitsueda R, Asai S, Kato M, Idichi T, Kurahara H, Ohtsuka T.  Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma.  Genes (Basel)  2023  14(5)  PubMed ID: 37239355   DOI: 10.3390/genes14050995
21290  Yamashita M, Kumazoe M, Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H.  PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer.  Biochem Biophys Res Commun  2023  672:154-160  PubMed ID: 37354608   DOI: 10.1016/j.bbrc.2023.06.043
21299  Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M.  Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma.  Cancer Res  2023  OF1-OF12  PubMed ID: 37378549   DOI: 10.1158/0008-5472.CAN-22-3762
21412  Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T.  Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer.  JCI Insight  2023    PubMed ID: 37733442   DOI: 10.1172/jci.insight.163022
21462  Baba K, Uemura K, Nakazato R, Ijaz F, Takahashi S, Ikegami K.  Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells.  Med Mol Morphol  2023    PubMed ID: 37930423   DOI: 10.1007/s00795-023-00373-w
21531  Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K.  CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses.  J Pharmacol Sci  2023  153(4):232-242  PubMed ID: 37973221   DOI: 10.1016/j.jphs.2023.10.003
21954  Kariya Y, Gu J, Kariya Y.  Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit  Biomolecules  2023  13(12):1752  PubMed ID: 38136623   DOI: 10.3390/biom13121752
17509  Maneenet J, Tawila AM, Omar AM, Phan ND, Ojima C, Kuroda M, Sato M, Mizoguchi M, Takahashi I, Awale S.  Chemical Constituents of Callistemon subulatus and Their Anti-Pancreatic Cancer Activity against Human PANC-1 Cell Line  Plants (Basel)  2022  11(19):2466  PubMed ID: 36235333   DOI: 10.3390/plants11192466
17698  Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe  Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i>  Advances in Microbiology  2022  12:649-670    DOI: 10.4236/aim.2022.1212045
17709  Kimura A, Arai T, Ueno M, Oyama K, Yu H, Yamashita S, Otome Y, Taguchi M.  Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis  Pharmaceutics  2022  14(11):2400  PubMed ID: 36365217   DOI: 10.3390/pharmaceutics14112400
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2022  e1485  PubMed ID: 34173723   DOI: 10.1002/cnr2.1485
20471  Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M.  ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway.  Pancreatology  2022    PubMed ID: 34642112   DOI: 10.1016/j.pan.2021.09.012
20558  Kohyama A, Kim MJ, Yokoyama R, Sun S, Omar AM, Phan ND, Meselhy MR, Tsuge K, Awale S, Matsuya Y.  Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate.  Bioorg Med Chem  2022  54:116563  PubMed ID: 34942553   DOI: 10.1016/j.bmc.2021.116563
16170  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.  Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)  ACS Chem Biol  2022  Feb 7.  PubMed ID: 35128925   DOI: 10.1021/acschembio.2c00028
20570  Vaes RDW, van Dijk DPJ, Farshadi EA, Olde Damink SWM, Rensen SS, Langen RC.  Human pancreatic tumour organoid-derived factors enhance myogenic differentiation.  J Cachexia Sarcopenia Muscle  2022    PubMed ID: 35146962   DOI: 10.1002/jcsm.12917
20531  Fujita T, Lin J, Kimishima A, Arai M, Takikawa H, Ogura Y.  Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells.  Biosci Biotechnol Biochem  2022    PubMed ID: 35157035   DOI: 10.1093/bbb/zbac025
20592  Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M.  Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.  J Exp Clin Cancer Res  2022  41(1):89  PubMed ID: 35272688   DOI: 10.1186/s13046-022-02301-9
20717  Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T.  Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.  PLoS One  2022  17(5)  PubMed ID: 35617311   DOI: 10.1371/journal.pone.0266620
16760  Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J.  Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy  Cancer Sci  2022  113(2):576-586  PubMed ID: 34808019   DOI: 10.1111/cas.15209
20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w
16849  Nguyen Ngoc Thanh Luan, Takuya Okada, Ruka Arata, Lanke Prudhvi, Moe Miyaguchi, Yuri Kodama, Suresh Awale, Naoki Toyooka  Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy  Tetrahedron  2022  132931    DOI: 10.1016/j.tet.2022.132931
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20858  Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, Fang L, Seubert JM, Ito K, Aoki S.  PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells.  Biochem Biophys Res Commun  2022  625:167-173  PubMed ID: 35963163   DOI: 10.1016/j.bbrc.2022.08.004
20976  Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H.  Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.  Br J Cancer  2022    PubMed ID: 36536047   DOI: 10.1038/s41416-022-02106-9
18117  Chao D, Ariake K, Sato S, Ohtsuka H, Takadate T, Ishida M, Masuda K, Maeda S, Miura T, Mitachi K, Yu XJ, Fujishima F, Mizuma M, Nakagawa K, Morikawa T, Kamei T, Unno M.  Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer  Oncol Rep  2021  45(6):90  PubMed ID: 33846782   DOI: 10.3892/or.2021.8041
13280  Labib PL, Yaghini E, Davidson BR, MacRobert AJ, Pereira SP.  5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies.  Transl Oncol  2021    PubMed ID: 33059124   DOI: 10.1016/j.tranon.2020.100886
13355  Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M.  Impact of Capicua on Pancreatic Cancer Progression.  Ann Surg Oncol  2021  28(6):3198-3207  PubMed ID: 33216264   DOI: 10.1245/s10434-020-09339-z
20018  Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K.  The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model.  J Surg Res  2021  261:351-360  PubMed ID: 33493887   DOI: 10.1016/j.jss.2020.12.046
20025  Sun S, Kim MJ, Dibwe DF, Omar AM, Athikomkulchai S, Phrutivorapongkul A, Okada T, Tsuge K, Toyooka N, Awale S.  Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora.  Plants (Basel)  2021  10(2)  PubMed ID: 33503922   DOI: 10.3390/plants10020229
20035  Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.  Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.  Glycoconj J  2021  38(1):45-54  PubMed ID: 33523362   DOI: 10.1007/s10719-020-09970-8
20094  Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S.  Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.  Fitoterapia  2021  104901  PubMed ID: 33794305   DOI: 10.1016/j.fitote.2021.104901
20096  Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M.  Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.  Pathobiology  2021  1-9  PubMed ID: 33794543   DOI: 10.1159/000514593
20099  Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H.  Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.  Anticancer Res  2021  41(4):1733-1744  PubMed ID: 33813377   DOI: 10.21873/anticanres.14938
20164  Sagara A, Nakata K, Yamashita T, Guan W, Zhong P, Matsumoto S, Endo S, Iwamoto C, Shindo K, Ikenaga N, Moriyama T, Ohuchida K, Mizumoto K, Nakamura M.  New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth.  Pancreatology  2021    PubMed ID: 33965328   DOI: 10.1016/j.pan.2021.04.002
20167  Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N.  Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential.  Pancreatology  2021  21(3):573-580  PubMed ID: 33541781   DOI: 10.1016/j.pan.2021.01.013
20186  Saito R, Kawaida H, Hosomura N, Amemiya H, Itakura J, Yamamoto A, Takiguchi K, Maruyama S, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Inoue S, Kono H, Ichikawa D.  Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression.  Ann Surg Oncol  2021    PubMed ID: 34101067   DOI: 10.1245/s10434-021-10250-4
20189  Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S.  Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.  Int J Radiat Oncol Biol Phys  2021    PubMed ID: 34112559   DOI: 10.1016/j.ijrobp.2021.04.001
14512  Ando H, Eshima K, Ishida T.  Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model  Biol Pharm Bull   2021  4(2):266-270  PubMed ID: 33518679   DOI: 10.1248/bpb.b20-00825
20254  Sun S, Kim MJ, Omar AM, Duy Phan N, Aoike M, Awale S.  GDP Induces PANC-1 Human Pancreatic Cancer Cell Death Preferentially under Nutrient Starvation by Inhibiting PI3K/Akt/mTOR/Autophagy Signaling Pathway.  Chem Biodivers  2021    PubMed ID: 34213070   DOI: 10.1002/cbdv.202100389
15289  Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K.  Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms  J Nat Med  2021  75(3):612-622  PubMed ID: 33813664   DOI: 10.1007/s11418-021-01507-z
20431  Shiozaki A, Konishi T, Kosuga T, Kudou M, Kurashima K, Inoue H, Shoda K, Arita T, Konishi H, Morimura R, Komatsu S, Ikoma H, Toma A, Kubota T, Fujiwara H, Okamoto K, Otsuji E.  Roles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells.  Int J Oncol  2021  59(4)  PubMed ID: 34414448   DOI: 10.3892/ijo.2021.5256
20448  Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T.  Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate.  Micromachines (Basel)  2021  12(11)  PubMed ID: 34832842   DOI: 10.3390/mi12111431
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9171  Haruhiko Fuwa, Mizuho Sato  A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells  Mar Drugs  2017  15 (10)  PubMed ID: 29053565   DOI: 10.3390/md15100320
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14206  Nguyen HX, Nguyen MTT, Nguyen NT, Awale S.  Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line  J Nat Prod  2017  80(8):2345-2352  PubMed ID: 28783356   DOI: 10.1021/acs.jnatprod.7b00375
14225  Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H.  PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma  Sci Rep  2017  7(1):1917.  PubMed ID: 28507327   DOI: 10.1038/s41598-017-02162-9
14244  Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S.  Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma  Oncotarget  2017  8(32):53180-53193  PubMed ID: 28881803   DOI: 10.18632/oncotarget.18261
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14252  Maki T, Ikeda H, Kuroda A, Kyogoku N, Yamamura Y, Tabata Y, Abiko T, Tsuchikawa T, Hida Y, Shichinohe T, Tanaka E, Kaga K, Hatanaka K, Matsuno Y, Imai N, Hirano S.  Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification  Int J Oncol  2017  50(1):129-140.  PubMed ID: 27922671   DOI: 10.3892/ijo.2016.3786
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14616  Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H.  Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression  Oncotarget  2017  8(7):12290-12300  PubMed ID: 28103577   DOI: 10.18632/oncotarget.14703
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