CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2095 : PANC-1]

3301 Yamada T, Okajima F, Ohwada S, Kondo Y Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions. Cell Mol Life Sci 1997 53:435-41 PubMed ID: 9176562 DOI: 10.1007/s000180050052

5077 Wu MC, Arimura GK, Yunis AA. Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int J Cancer 1978 22(6):728-33 PubMed ID: 363626 DOI: 10.1002/ijc.2910220615

3459 Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas. Int J Cancer 1975 15:741-7 PubMed ID: 1140870 DOI: 10.1002/ijc.2910150505

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22478 Akagi S, Ando H, Matsuo CNA, Tajima K, Takata H, Matsushima T, Kusano T, Ishida T. A 3D Cell-Culture System That Uses Nano-Fibrillated Bacterial Cellulose to Prepare a Spherical Formulation of Culture Cells Biol Pharm Bull 2025 48(1):23-32 PubMed ID: 39864853 DOI: 10.1248/bpb.b24-00804

22543 Kato A, Nomura S, Takahashi M, Sukowati EW, Harashima H, Mukai H. Tumor-stromal opening via S. typhimurium VNP20009 administration for complete inhibition of refractory tumor growth with liposomal anticancer drugs. J Control Release 2025 PubMed ID: 39993636 DOI: 10.1016/j.jconrel.2025.02.064

22609 Shirakawa K, Nakazato R, Hara T, Uemura K, Ijaz F, Takahashi S, Ikegami K. A type of pancreatic cancer cells form cell clusters from a solitary condition in a primary ciliogenesis-dependent manner. Med Mol Morphol 2025 PubMed ID: 40069423 DOI: 10.1007/s00795-025-00428-0

22873 Zhang R, Danshiitsoodol N, Noda M, Yonezawa S, Kanno K, Sugiyama M. Stevia Leaf Extract Fermented with Plant-Derived Lactobacillus plantarum SN13T Displays Anticancer Activity to Pancreatic Cancer PANC-1 Cell Line Int J Mol Sci 2025 26(9):4186 PubMed ID: 40362423 DOI: 10.3390/ijms26094186

23183 Zhang Z, Fang L, Furukawa H, Huang A, Kranrod J, Seubert JM, Ito K, Aoki S. Maladaptive role of peridroplet mitochondria during lipophagy disruption in pancreatic cancer. Biochem Biophys Res Commun 2025 782:152609 PubMed ID: 40915065 DOI: 10.1016/j.bbrc.2025.152609

23292 Maneenet J, Tawila AM, Nguyen HH, Phan ND, Monthakantirat O, Daodee S, Boonyarat C, Khamphukdee C, Chulikhit Y, Awale S. Calliviminone A from Callistemon citrinus Induces PANC-1 Pancreatic Cancer Cell Death by Targeting the PI3K/Akt/mTOR Pathway Plants (Basel) 2025 14(13):2074 PubMed ID: 40648084 DOI: 10.3390/plants14132074

23321 Kumai J, Sasagawa S, Yui Y. Metastatic breast cancer cells adapt to a soft environment with limited involvement of mechanotransduction Exp Cell Res 2025 450(2):114629 PubMed ID: 40466802 DOI: 10.1016/j.yexcr.2025.114629

23384 Maneenet J, Awale S, Boonyarat C, Waiwut P, Kaewamatawong R. Anti-cancer activity of 7-methoxyheptaphylline from Clausena harmandiana against PANC-1 pancreatic cancer cells and its sustainable extraction method. PLoS One 2025 20(10):e0334901 PubMed ID: 41100558 DOI: 10.1371/journal.pone.0334901

19817 Miyata S, Ishii T, Kitanaka S. Reduction of HIF-1α/PD-L1 by Catalytic Topoisomerase Inhibitor Induces Cell Death Through Caspase Activation in Cancer Cells Under Hypoxia Anticancer Res 2024 44(1):49-59 PubMed ID: 38159998 DOI: 10.21873/anticanres.16787

19848 Yamanaka T, Araki K, Yokobori T, Muranushi R, Hoshino K, Hagiwara K, Gantumur D, Ishii N, Tsukagoshi M, Watanabe A, Harimoto N, Masamune A, Uojima H, Mizokami M, Ito K, Shirabe K. Potential of Mac-2-binding protein glycan isomer as a new therapeutic target in pancreatic cancer Cancer Sci 2024 Feb 6 PubMed ID: 38321872 DOI: 10.1111/cas.16087

21462 Baba K, Uemura K, Nakazato R, Ijaz F, Takahashi S, Ikegami K. Δ3-tubulin impairs mitotic spindle morphology and increases nuclear size in pancreatic cancer cells. Med Mol Morphol 2024 57(1):59-67 PubMed ID: 37930423 DOI: 10.1007/s00795-023-00373-w

21666 Zhang Z, Aoki H, Umezawa K, Kranrod J, Miyazaki N, Oshima T, Hirao T, Miura Y, Seubert J, Ito K, Aoki S. Potential role of lipophagy impairment for anticancer effects of glycolysis-suppressed pancreatic ductal adenocarcinoma cells. Cell Death Discov 2024 10(1):166 PubMed ID: 38580661 DOI: 10.1038/s41420-024-01933-4

21692 Tazuma S, Sudo T, Ishikawa A, Yamaguchi A, Shibata Y, Ishida Y, Kuraoka K, Uemura K, Takahashi S, Tashiro H. Effects of transmembrane serine protease 4 on the survival in patients with pancreatic ductal adenocarcinoma undergoing surgery followed by adjuvant chemotherapy. Surg Today 2024 PubMed ID: 38637344 DOI: 10.1007/s00595-024-02824-y

21722 Zhong P, Nakata K, Oyama K, Higashijima N, Sagara A, Date S, Luo H, Hayashi M, Kubo A, Wu C, He S, Yamamoto T, Koikawa K, Iwamoto C, Abe T, Ikenaga N, Ohuchida K, Morisaki T, Oda Y, Kuba K, Nakamura M. Blockade of histamine receptor H1 augments immune checkpoint therapy by enhancing MHC-I expression in pancreatic cancer cells. J Exp Clin Cancer Res 2024 43(1):138 PubMed ID: 38715057 DOI: 10.1186/s13046-024-03060-5

21802 Akimoto T, Islam MR, Nagasako A, Kishi K, Nakakaji R, Ohtake M, Hasumi H, Yamaguchi T, Yamada S, Yamamoto T, Ishikawa Y, Umemura M. Alternative magnetic field exposure suppresses tumor growth via metabolic reprogramming. Cancer Sci 2024 PubMed ID: 38877783 DOI: 10.1111/cas.16243

21897 Takata T, Nakamura A, Yasuda H, Miyake H, Sogame Y, Sawai Y, Hayakawa M, Mochizuki K, Nakao R, Ogata T, Ikoma H, Konishi E, Harada Y, Otsuji E, Itoh Y, Tanaka H. Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors Acta Histochem Cytochem 2024 57(2):57-66 PubMed ID: 38695038 DOI: 10.1267/ahc.24-00010

21916 Kiichi Y, Fukuoka K, Kitano A, Ishino K, Kotoku N. Unified Synthesis and Biological Evaluation of Makaluvamine J and Its Analogs Molecules 2024 29(6):1389 PubMed ID: 38543025 DOI: 10.3390/molecules29061389

22062 Terai T, Nishiwada S, Nagai M, Nakamura K, Kohara Y, Yasuda S, Matsuo Y, Doi S, Sakata T, Kumada H, Watanabe M, Sho M. Clinical impact of carbonic anhydrase 9 expression on neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma. Pancreatology 2024 24(6):938-946 PubMed ID: 39152081 DOI: 10.1016/j.pan.2024.08.003

22131 Kawataki S, Kubota Y, Katayama K, Imoto S, Takekawa M. GADD45β-MTK1 signaling axis mediates oncogenic stress-induced activation of the p38 and JNK pathways. Cancer Sci 2024 PubMed ID: 39526327 DOI: 10.1111/cas.16389

22336 Kaneda-Nakashima K, Shirakami Y, Hisada K, Feng S, Kadonaga Y, Ooe K, Watabe T, Manabe Y, Shimoyama A, Murakami M, Toyoshima A, Haba H, Kanai Y, Fukase K. Development of LAT1-Selective Nuclear Medicine Therapeutics Using Astatine-211 Int J Mol Sci 2024 25(22):12386 PubMed ID: 39596451 DOI: 10.3390/ijms252212386

22346 Tsunetoshi Y, Sanada F, Kanemoto Y, Shibata K, Masamune A, Taniyama Y, Yamamoto K, Morishita R. A Role for Periostin Pathological Variants and Their Interaction with HSP70-1a in Promoting Pancreatic Cancer Progression and Chemoresistance Int J Mol Sci 2024 25(23):13205 PubMed ID: 39684914 DOI: 10.3390/ijms252313205

22874 Yumi Sugo, Atsushi Kimura, Tomoya Koizumi, Kotaro Oyama, Mitsumasa Taguchi Development of gelatin nanoparticles for positron emission tomography diagnosis in pancreatic cancer Radiochimica Acta 2024 112:971-980 DOI: 10.1515/ract-2024-0304

18285 Yamakawa K, Koyanagi-Aoi M, Machinaga A, Kakiuchi N, Hirano T, Kodama Y, Aoi T. Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase Cancer Cell Int 2023 23(1):94 PubMed ID: 37198667 DOI: 10.1186/s12935-023-02928-4

19616 Masuo H, Kubota K, Shimizu A, Notake T, Miyazaki S, Yoshizawa T, Sakai H, Hayashi H, Soejima Y. Increased mitochondria are responsible for the acquisition of gemcitabine resistance in pancreatic cancer cell lines Cancer Sci 2023 114(11):4388-4400 PubMed ID: 37700464 DOI: 10.1111/cas.15962

19617 Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K. Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment Cancer Sci 2023 114(11):4286-4298 PubMed ID: 37688308 DOI: 10.1111/cas.15952

19678 Fujihashi Y, Jo Kim M, Maneenet J, Awale S. Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation Chem Biodivers 2023 20(9):e202300280 PubMed ID: 37612242 DOI: 10.1002/cbdv.202300280

19693 Batbayar C, Ishii N, Harimoto N, Yokobori T, Saito H, Gantumur D, Gombodorj N, Erkhem-Ochir B, Muranushi R, Hoshino K, Yamanaka T, Hagiwara K, Tsukagoshi M, Watanabe A, Araki K, Hosouchi Y, Shirabe K. High RRN3 expression is associated with malignant characteristics and poor prognosis in pancreatic cancer Int J Clin Oncol 2023 28(7):901-912 PubMed ID: 37119370 DOI: 10.1007/s10147-023-02342-w

19793 Tomohara K, Maneenet J, Ohashi N, Nose T, Fujii R, Kim MJ, Sun S, Awale S. Ugi Adducts as Novel Anti-austerity Agents against PANC-1 Human Pancreatic Cancer Cell Line: A Rapid Synthetic Approach Biol Pharm Bull 2023 46(10):1412-1420 PubMed ID: 37779042 DOI: 10.1248/bpb.b23-00224

20976 Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H. Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer 2023 28(5):844-856 PubMed ID: 36536047 DOI: 10.1038/s41416-022-02106-9

21009 Doi Y, Wakana D, Kitaoka S, Sato F, Tanaka E, Takeda H, Hosoe T. Ergot alkaloids in sclerotia collected in Japan: synthetic profiles and induction of apoptosis by Clavine-type compounds. J Nat Med 2023 PubMed ID: 36635416 DOI: 10.1007/s11418-022-01673-8

21044 Yamada T, Tateishi R, Iwai M, Tanaka M, Ijichi H, Sano M, Koike K, Todo T. Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors. Mol Ther Oncolytics 2023 28:31-43 PubMed ID: 36619294 DOI: 10.1016/j.omto.2022.12.001

21057 Masuda M, Asuka T, Terao N, Nishino S, Ikeda S, Takamatsu S, Kondo J, Miyoshi E. Establishment of a novel 70K Mac-2 binding protein antibody through screening of fucosylation-related antibodies. J Biochem 2023 PubMed ID: 36760066 DOI: 10.1093/jb/mvad015

21107 Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S. Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model. J Nat Prod 2023 PubMed ID: 36938707 DOI: 10.1021/acs.jnatprod.3c00019

21138 Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR. A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy. Cell Rep Med 2023 PubMed ID: 37003259 DOI: 10.1016/j.xcrm.2023.100960

21177 Ouchida T, Maeda H, Akamatsu Y, Maeda M, Takamatsu S, Kondo J, Misaki R, Kamada Y, Ueda M, Ueda K, Miyoshi E. The specific core fucose-binding lectin Pholiota squarrosa lectin (PhoSL) inhibits hepatitis B virus infection in vitro. Sci Rep 2023 13(1):6175 PubMed ID: 37061516 DOI: 10.1038/s41598-023-28572-6

21197 Ando H, Eshima K, Ishida T. A polyethylene glycol-conjugate of deoxycytidine analog, DFP-14927, produces potential antitumor effects on pancreatic tumor-xenograft murine models via inducing G2/M arrest. Eur J Pharmacol 2023 950:175758 PubMed ID: 37121563 DOI: 10.1016/j.ejphar.2023.175758

21234 Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N. Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation. J Med Chem 2023 PubMed ID: 37257133 DOI: 10.1021/acs.jmedchem.3c00394

21257 Fukuda K, Seki N, Yasudome R, Mitsueda R, Asai S, Kato M, Idichi T, Kurahara H, Ohtsuka T. Coronin 1C, Regulated by Multiple microRNAs, Facilitates Cancer Cell Aggressiveness in Pancreatic Ductal Adenocarcinoma. Genes (Basel) 2023 14(5) PubMed ID: 37239355 DOI: 10.3390/genes14050995

21290 Yamashita M, Kumazoe M, Onda H, Hiroi S, Shimada Y, Fujimura Y, Tachibana H. PPAR/PDK4 pathway is involved in the anticancer effects of cGMP in pancreatic cancer. Biochem Biophys Res Commun 2023 672:154-160 PubMed ID: 37354608 DOI: 10.1016/j.bbrc.2023.06.043

21299 Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M. Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma. Cancer Res 2023 OF1-OF12 PubMed ID: 37378549 DOI: 10.1158/0008-5472.CAN-22-3762

21412 Kitamura F, Semba T, Yasuda-Yoshihara N, Yamada K, Nishimura A, Yamasaki J, Nagano O, Yasuda T, Yonemura A, Tong Y, Wang H, Akiyama T, Matsumura K, Uemura N, Itoyama R, Bu L, Fu L, Hu X, Wei F, Mima K, Imai K, Hayashi H, Yamashita YI, Miyamoto Y, Baba H, Ishimoto T. Cancer-associated fibroblasts reuse cancer-derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer. JCI Insight 2023 PubMed ID: 37733442 DOI: 10.1172/jci.insight.163022

21531 Imanishi M, Inoue T, Fukushima K, Yamashita R, Nakayama R, Nojima M, Kondo K, Gomi Y, Tsunematsu H, Goto K, Miyamoto L, Funamoto M, Denda M, Ishizawa K, Otaka A, Fujino H, Ikeda Y, Tsuchiya K. CA9 and PRELID2; hypoxia-responsive potential therapeutic targets for pancreatic ductal adenocarcinoma as per bioinformatics analyses. J Pharmacol Sci 2023 153(4):232-242 PubMed ID: 37973221 DOI: 10.1016/j.jphs.2023.10.003

21954 Kariya Y, Gu J, Kariya Y. Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3-Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit Biomolecules 2023 13(12):1752 PubMed ID: 38136623 DOI: 10.3390/biom13121752

22192 Fang L, Yuan S, Wang M, Zhang C, Wang X, Li H, Yang J, Li W, Sun N, Zhang Q, Zhang Y, Chai D, Li H, Zheng J, Wang G. Recombinant oncolytic adenovirus armed with CCL5, IL-12, and IFN-γ promotes CAR-T infiltration and proliferation in vivo to eradicate local and distal tumors Cell Death Discov 2023 9(1):328 PubMed ID: 37660142 DOI: 10.1038/s41420-023-01626-4

17509 Maneenet J, Tawila AM, Omar AM, Phan ND, Ojima C, Kuroda M, Sato M, Mizoguchi M, Takahashi I, Awale S. Chemical Constituents of Callistemon subulatus and Their Anti-Pancreatic Cancer Activity against Human PANC-1 Cell Line Plants (Basel) 2022 11(19):2466 PubMed ID: 36235333 DOI: 10.3390/plants11192466

17698 Yuji Doi, Daigo Wakana, Satoshi Kitaoka, Hisashi Takeda, Eiji Tanaka, Tomoo Hosoe Secalonic Acid and Benzoic Acid Analogues Exhibiting Cyto toxicity against Cancer Cells Isolated from <i>Claviceps yanagawaensis</i> Advances in Microbiology 2022 12:649-670 DOI: 10.4236/aim.2022.1212045

17709 Kimura A, Arai T, Ueno M, Oyama K, Yu H, Yamashita S, Otome Y, Taguchi M. Synthesis of Small Peptide Nanogels Using Radiation Crosslinking as a Platform for Nano-Imaging Agents for Pancreatic Cancer Diagnosis Pharmaceutics 2022 14(11):2400 PubMed ID: 36365217 DOI: 10.3390/pharmaceutics14112400

20214 Ando H, Murakami Y, Eshima K, Ishida T. A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML). Cancer Rep (Hoboken) 2022 e1485 PubMed ID: 34173723 DOI: 10.1002/cnr2.1485

20471 Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M. ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway. Pancreatology 2022 PubMed ID: 34642112 DOI: 10.1016/j.pan.2021.09.012

20538 Hassan G, Ohara T, Afify SM, Kumon K, Zahra MH, Fu X, Al Kadi M, Seno A, Salomon DS, Seno M. Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways. J Exp Clin Cancer Res 2022 41(1):29 PubMed ID: 35063003 DOI: 10.1186/s13046-021-02167-3

20558 Kohyama A, Kim MJ, Yokoyama R, Sun S, Omar AM, Phan ND, Meselhy MR, Tsuge K, Awale S, Matsuya Y. Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate. Bioorg Med Chem 2022 54:116563 PubMed ID: 34942553 DOI: 10.1016/j.bmc.2021.116563

16170 Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1) ACS Chem Biol 2022 Feb 7. PubMed ID: 35128925 DOI: 10.1021/acschembio.2c00028

20570 Vaes RDW, van Dijk DPJ, Farshadi EA, Olde Damink SWM, Rensen SS, Langen RC. Human pancreatic tumour organoid-derived factors enhance myogenic differentiation. J Cachexia Sarcopenia Muscle 2022 PubMed ID: 35146962 DOI: 10.1002/jcsm.12917

20531 Fujita T, Lin J, Kimishima A, Arai M, Takikawa H, Ogura Y. Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells. Biosci Biotechnol Biochem 2022 PubMed ID: 35157035 DOI: 10.1093/bbb/zbac025

20592 Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M. Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses. J Exp Clin Cancer Res 2022 41(1):89 PubMed ID: 35272688 DOI: 10.1186/s13046-022-02301-9

20717 Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T. Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma. PLoS One 2022 17(5) PubMed ID: 35617311 DOI: 10.1371/journal.pone.0266620

16760 Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J. Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy Cancer Sci 2022 113(2):576-586 PubMed ID: 34808019 DOI: 10.1111/cas.15209

20774 Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M. Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer. Nat Commun 2022 13(1):4063 PubMed ID: 35831322 DOI: 10.1038/s41467-022-31690-w

16849 Nguyen Ngoc Thanh Luan, Takuya Okada, Ruka Arata, Lanke Prudhvi, Moe Miyaguchi, Yuri Kodama, Suresh Awale, Naoki Toyooka Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy Tetrahedron 2022 132931 DOI: 10.1016/j.tet.2022.132931

20799 Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Nat Commun 2022 13(1):4355 PubMed ID: 35906200 DOI: 10.1038/s41467-022-32034-4

20858 Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, Fang L, Seubert JM, Ito K, Aoki S. PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells. Biochem Biophys Res Commun 2022 625:167-173 PubMed ID: 35963163 DOI: 10.1016/j.bbrc.2022.08.004

18117 Chao D, Ariake K, Sato S, Ohtsuka H, Takadate T, Ishida M, Masuda K, Maeda S, Miura T, Mitachi K, Yu XJ, Fujishima F, Mizuma M, Nakagawa K, Morikawa T, Kamei T, Unno M. Stomatin‑like protein 2 induces metastasis by regulating the expression of a rate‑limiting enzyme of the hexosamine biosynthetic pathway in pancreatic cancer Oncol Rep 2021 45(6):90 PubMed ID: 33846782 DOI: 10.3892/or.2021.8041

13280 Labib PL, Yaghini E, Davidson BR, MacRobert AJ, Pereira SP. 5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies. Transl Oncol 2021 PubMed ID: 33059124 DOI: 10.1016/j.tranon.2020.100886

13355 Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M. Impact of Capicua on Pancreatic Cancer Progression. Ann Surg Oncol 2021 28(6):3198-3207 PubMed ID: 33216264 DOI: 10.1245/s10434-020-09339-z

20018 Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K. The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model. J Surg Res 2021 261:351-360 PubMed ID: 33493887 DOI: 10.1016/j.jss.2020.12.046

20025 Sun S, Kim MJ, Dibwe DF, Omar AM, Athikomkulchai S, Phrutivorapongkul A, Okada T, Tsuge K, Toyooka N, Awale S. Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora. Plants (Basel) 2021 10(2) PubMed ID: 33503922 DOI: 10.3390/plants10020229

20035 Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E. Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism. Glycoconj J 2021 38(1):45-54 PubMed ID: 33523362 DOI: 10.1007/s10719-020-09970-8

20094 Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S. Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line. Fitoterapia 2021 104901 PubMed ID: 33794305 DOI: 10.1016/j.fitote.2021.104901

20096 Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M. Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential. Pathobiology 2021 1-9 PubMed ID: 33794543 DOI: 10.1159/000514593

20099 Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H. Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells. Anticancer Res 2021 41(4):1733-1744 PubMed ID: 33813377 DOI: 10.21873/anticanres.14938

20164 Sagara A, Nakata K, Yamashita T, Guan W, Zhong P, Matsumoto S, Endo S, Iwamoto C, Shindo K, Ikenaga N, Moriyama T, Ohuchida K, Mizumoto K, Nakamura M. New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth. Pancreatology 2021 PubMed ID: 33965328 DOI: 10.1016/j.pan.2021.04.002

20167 Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N. Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential. Pancreatology 2021 21(3):573-580 PubMed ID: 33541781 DOI: 10.1016/j.pan.2021.01.013

20186 Saito R, Kawaida H, Hosomura N, Amemiya H, Itakura J, Yamamoto A, Takiguchi K, Maruyama S, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Inoue S, Kono H, Ichikawa D. Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression. Ann Surg Oncol 2021 PubMed ID: 34101067 DOI: 10.1245/s10434-021-10250-4

20189 Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer. Int J Radiat Oncol Biol Phys 2021 PubMed ID: 34112559 DOI: 10.1016/j.ijrobp.2021.04.001

14512 Ando H, Eshima K, Ishida T. Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model Biol Pharm Bull 2021 4(2):266-270 PubMed ID: 33518679 DOI: 10.1248/bpb.b20-00825

20254 Sun S, Kim MJ, Omar AM, Duy Phan N, Aoike M, Awale S. GDP Induces PANC-1 Human Pancreatic Cancer Cell Death Preferentially under Nutrient Starvation by Inhibiting PI3K/Akt/mTOR/Autophagy Signaling Pathway. Chem Biodivers 2021 PubMed ID: 34213070 DOI: 10.1002/cbdv.202100389

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20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

20431 Shiozaki A, Konishi T, Kosuga T, Kudou M, Kurashima K, Inoue H, Shoda K, Arita T, Konishi H, Morimura R, Komatsu S, Ikoma H, Toma A, Kubota T, Fujiwara H, Okamoto K, Otsuji E. Roles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells. Int J Oncol 2021 59(4) PubMed ID: 34414448 DOI: 10.3892/ijo.2021.5256

20436 Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K. Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes. Biochem Biophys Res Commun 2021 578:170-176 PubMed ID: 34597914 DOI: 10.1016/j.bbrc.2021.08.054

20448 Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T. Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate. Micromachines (Basel) 2021 12(11) PubMed ID: 34832842 DOI: 10.3390/mi12111431

16171 Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A. Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion Elife 2021 10:e66721 PubMed ID: 34590580 DOI: 10.7554/eLife.66721

16214 PRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI, TAKAO OHTSUKA Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma Anticancer Res 2021 41(10):4821-4836 PubMed ID: 34593431 DOI: 10.21873/anticanres.15297

16522 Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H. Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth ACS Chem Biol 2021 16(8):1576-1586 PubMed ID: 34296611 DOI: 10.1021/acschembio.1c00480

16701 Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D. Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly J Cell Biol 2021 220(2):e202006085 PubMed ID: 33443571 DOI: 10.1083/jcb.202006085

16776 Sijia Sun, Min Jo Kim, Ashraf M. Omar, Nguyen Duy Phan, Suresh Awale (+)-Panduratin A induces PANC-1 human pancreatic cancer cell death preferentially under nutrient starvation by inhibiting PI3K/Akt/mTOR/autophagy signaling pathway Phytomedicine Plus 2021 1:100101 DOI: 10.1016/j.phyplu.2021.100101

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16778 Jinno N, Yoshida M, Hayashi K, Naitoh I, Hori Y, Natsume M, Kato A, Kachi K, Asano G, Atsuta N, Sahashi H, Kataoka H. Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer Cancer Sci 2021 112(2):668-678 PubMed ID: 33053268 DOI: 10.1111/cas.14689

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22193 Feng H, Moriyama T, Ohuchida K, Sheng N, Iwamoto C, Shindo K, Shirahane K, Ikenaga N, Nagai S, Nakata K, Mizumoto K, Nakamura M. N-acetyl cysteine induces quiescent-like pancreatic stellate cells from an active state and attenuates cancer-stroma interactions J Exp Clin Cancer Res 2021 40(1):133 PubMed ID: 33858491 DOI: 10.1186/s13046-021-01939-1

19227 Hirai K, Watanabe S, Nishijima N, Shibata K, Hase A, Yamanaka T, Inazu M. Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells Int J Mol Sci 2020 21(15):5190 PubMed ID: 32707889 DOI: 10.3390/ijms21155190

19263 Furuhashi S, Sakaguchi T, Murakami T, Fukushima M, Morita Y, Ikegami K, Kikuchi H, Setou M, Takeuchi H. Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma Pancreas 2020 49(3):442-454 PubMed ID: 32132519 DOI: 10.1097/MPA.0000000000001506

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11920 Takumi Chinen , Shohei Yamamoto, Yutaka Takeda , Koki Watanabe, Kanako Kuroki , Kaho Hashimoto , Daisuke Takao , Daiju Kitagawa NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells EMBO J 2020 PubMed ID: 31782546 DOI: 10.15252/embj.2019102378

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10053 Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN. Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents. Biomater Sci 2017 5:432-443 PubMed ID: 28059418 DOI: 10.1039/c6bm00621c

10086 Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S. Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line. J. Nat. Prod. 2017 80:141-148 PubMed ID: 28099006 DOI: 10.1021/acs.jnatprod.6b00784

10112 Asano M, Sakaguchi M, Tanaka S, Kashimura K, Mitani T, Kawase M, Matsumura H, Yamaguchi T, Fujita Y, Tabuse K. Effects of Normothermic Conditioned Microwave Irradiation on Cultured Cells Using an Irradiation System with Semiconductor Oscillator and Thermo-regulatory Applicator. Sci Rep 2017 7:41244 PubMed ID: 28145466 DOI: 10.1038/srep41244

10311 Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Kangawa K, Tachibana H. The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J. Biol. Chem. 2017 292:10813-10823 PubMed ID: 28507102 DOI: 10.1074/jbc.M116.772111

10337 Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M. The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy. PLoS ONE 2017 12:e0178221 PubMed ID: 28558031 DOI: 10.1371/journal.pone.0178221

10399 Fujita M, Hasegawa A, Yamamori M, Okamura N. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J. Exp. Clin. Cancer Res. 2017 36:91 PubMed ID: 28673319 DOI: 10.1186/s13046-017-0557-6

10448 Arai MA, Utsumi T, Yanase N, Fujimatsu T, Ishibashi M. Efficient Synthesis of Heterocyclic Flavonoids with Hedgehog Signal Inhibitory Activity. Chem. Pharm. Bull. 2017 65:784-795 PubMed ID: 28768932 DOI: 10.1248/cpb.c17-00305

10481 Endo S, Nakata K, Sagara A, Koikawa K, Ando Y, Kibe S, Takesue S, Nakayama H, Abe T, Okumura T, Moriyama T, Miyasaka Y, Ohuchida K, Ohtsuka T, Mizumoto K, Nakamura M. Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells. Pancreatology 2017 17:990-996 PubMed ID: 28927939 DOI: 10.1016/j.pan.2017.08.009

10537 Kawamura D, Takemoto Y, Nishimoto A, Ueno K, Hosoyama T, Shirasawa B, Tanaka T, Kugimiya N, Harada E, Hamano K. Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells. Oncol. Rep. 2017 38:3238-3244 PubMed ID: 29048622 DOI: 10.3892/or.2017.5974

19427 Midori A. Arai, Masami Ishibashi, Tatsuro Yoneyama, Takashi Koyano, Thaworn Kowithayakorn Isolation and Evaluation of Hedgehog Inhibitors from Christmas Grass (Themeda arguens) HETEROCYCLES 2017 95:210 DOI: 10.3987/com-16-s(s)4

11010 Ancistrolikokines E–H and related 5,8′-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko with antiausterity activities against PANC-1 human pancreatic cancer cells RSC Adv. 2017 7, 53740-53751 DOI: 10.1039/C7RA11200A

5446 Endo S1, Nakata K2, Ohuchida K3, Takesue S1, Nakayama H1, Abe T1, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C5, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice. Gastroenterology 2017 152(6):1492-1506 PubMed ID: 28126348 DOI: 10.1053/j.gastro.2017.01.010

9171 Haruhiko Fuwa, Mizuho Sato A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells Mar Drugs 2017 15 (10) PubMed ID: 29053565 DOI: 10.3390/md15100320

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14206 Nguyen HX, Nguyen MTT, Nguyen NT, Awale S. Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line J Nat Prod 2017 80(8):2345-2352 PubMed ID: 28783356 DOI: 10.1021/acs.jnatprod.7b00375

14225 Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H. PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma Sci Rep 2017 7(1):1917. PubMed ID: 28507327 DOI: 10.1038/s41598-017-02162-9

14244 Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S. Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma Oncotarget 2017 8(32):53180-53193 PubMed ID: 28881803 DOI: 10.18632/oncotarget.18261

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14616 Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H. Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression Oncotarget 2017 8(7):12290-12300 PubMed ID: 28103577 DOI: 10.18632/oncotarget.14703

14655 Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H. Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion Cancer Res 2017 77(9):2328-2338 PubMed ID: 28202517 DOI: 10.1158/0008-5472.CAN-16-1846

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14726 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E. Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer Sci Rep 2017 7(1):5708 PubMed ID: 28720759 DOI: 10.1038/s41598-017-06137-8

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