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Cell No. : Cell Name
RCB2095 : PANC-1  update : 2022/11/11
CommentHuman cell line derived from pancreatic cancer. Ductal origin. TKG0606 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Year of deposit 2005
Original cell TKG0606
Animal human < Mammals
Genus Homo
Species sapiens
Gender Unknown
Tissue pancreas
Disease name Pancreaticcarcinoma of ductal origin
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0606)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0480
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin + (0.02% EDTA or 0.04% EDTA)
Culture information Passage ratio 1 : 4-8 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Animal PCR OK
STR(human) OK
Images
deposit info
lot info
Reference information Reference 3
User's Publication 161


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Reference
3301  Yamada T, Okajima F, Ohwada S, Kondo Y  Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions.  Cell Mol Life Sci  1997  53:435-41  PubMed ID: 9176562  
5077  Wu MC, Arimura GK, Yunis AA.  Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase.  Int J Cancer  1978  22(6):728-33  PubMed ID: 363626   DOI: 10.1002/ijc.2910220615
3459  Lieber M, Mazzetta J, Nelson-Rees W, Kaplan M, Todaro G  Establishment of a continuous tumor-cell line (panc-1) from a human carcinoma of the exocrine pancreas.  Int J Cancer  1975  15:741-7  PubMed ID: 1140870   DOI: 10.1002/ijc.2910150505

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User's Publication
20214  Ando H, Murakami Y, Eshima K, Ishida T.  A novel polyethylene glycol (PEG)-drug conjugate of Venetoclax, a Bcl-2 inhibitor, for treatment of acute myeloid leukemia (AML).  Cancer Rep (Hoboken)  2022  e1485  PubMed ID: 34173723   DOI: 10.1002/cnr2.1485
20471  Guan W, Nakata K, Sagara A, Iwamoto C, Endo S, Matsuda R, Matsumoto S, Ikenaga N, Shindo K, Moriyama T, Onishi H, Ohuchida K, Oda Y, Nakamura M.  ERAP2 is a novel target involved in autophagy and activation of pancreatic stellate cells via UPR signaling pathway.  Pancreatology  2022    PubMed ID: 34642112   DOI: 10.1016/j.pan.2021.09.012
20558  Kohyama A, Kim MJ, Yokoyama R, Sun S, Omar AM, Phan ND, Meselhy MR, Tsuge K, Awale S, Matsuya Y.  Structure-activity relationship and mechanistic study on guggulsterone derivatives; Discovery of new anti-pancreatic cancer candidate.  Bioorg Med Chem  2022  54:116563  PubMed ID: 34942553   DOI: 10.1016/j.bmc.2021.116563
16170  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.  Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)  ACS Chem Biol  2022  Feb 7.  PubMed ID: 35128925   DOI: 10.1021/acschembio.2c00028
20570  Vaes RDW, van Dijk DPJ, Farshadi EA, Olde Damink SWM, Rensen SS, Langen RC.  Human pancreatic tumour organoid-derived factors enhance myogenic differentiation.  J Cachexia Sarcopenia Muscle  2022    PubMed ID: 35146962   DOI: 10.1002/jcsm.12917
20531  Fujita T, Lin J, Kimishima A, Arai M, Takikawa H, Ogura Y.  Synthesis and Biological Evaluation of Cajaninstilbene Acid and Amorfrutins A-D as Cytotoxic Agents against Human Pancreatic Carcinoma PANC-1 Cells.  Biosci Biotechnol Biochem  2022    PubMed ID: 35157035   DOI: 10.1093/bbb/zbac025
20592  Shinkawa T, Ohuchida K, Mochida Y, Sakihama K, Iwamoto C, Abe T, Ideno N, Mizuuchi Y, Shindo K, Ikenaga N, Moriyama T, Nakata K, Oda Y, Nakamura M.  Subtypes in pancreatic ductal adenocarcinoma based on niche factor dependency show distinct drug treatment responses.  J Exp Clin Cancer Res  2022  41(1):89  PubMed ID: 35272688   DOI: 10.1186/s13046-022-02301-9
20717  Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T.  Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.  PLoS One  2022  17(5)  PubMed ID: 35617311   DOI: 10.1371/journal.pone.0266620
16760  Yuki A, Fujii C, Yamanoi K, Matoba H, Harumiya S, Kawakubo M, Nakayama J.  Glycosylation of MUC6 by α1,4-linked N-acetylglucosamine enhances suppression of pancreatic cancer malignancy  Cancer Sci  2022  113(2):576-586  PubMed ID: 34808019   DOI: 10.1111/cas.15209
20774  Kubota Y, Fujioka Y, Patil A, Takagi Y, Matsubara D, Iijima M, Momose I, Naka R, Nakai K, Noda NN, Takekawa M.  Qualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.  Nat Commun  2022  13(1):4063  PubMed ID: 35831322   DOI: 10.1038/s41467-022-31690-w
16849  Nguyen Ngoc Thanh Luan, Takuya Okada, Ruka Arata, Lanke Prudhvi, Moe Miyaguchi, Yuri Kodama, Suresh Awale, Naoki Toyooka  Structure-activity relationship study of 4′-O-methylgrynullarin derivatives for the development of novel anticancer agents based on anti-austerity strategy  Tetrahedron  2022  132931    DOI: 10.1016/j.tet.2022.132931
20799  Fujimoto M, Takii R, Matsumoto M, Okada M, Nakayama KI, Nakato R, Fujiki K, Shirahige K, Nakai A.  HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.  Nat Commun  2022  13(1):4355  PubMed ID: 35906200   DOI: 10.1038/s41467-022-32034-4
20858  Miyazaki N, Shiratori R, Oshima T, Zhang Z, Valencia R, Kranrod J, Fang L, Seubert JM, Ito K, Aoki S.  PINK1-dependent and Parkin-independent mitophagy is involved in reprogramming of glycometabolism in pancreatic cancer cells.  Biochem Biophys Res Commun  2022  625:167-173  PubMed ID: 35963163   DOI: 10.1016/j.bbrc.2022.08.004
13280  Labib PL, Yaghini E, Davidson BR, MacRobert AJ, Pereira SP.  5-Aminolevulinic acid for fluorescence-guided surgery in pancreatic cancer: Cellular transport and fluorescence quantification studies.  Transl Oncol  2021    PubMed ID: 33059124   DOI: 10.1016/j.tranon.2020.100886
13355  Yoshiya S, Itoh S, Yoshizumi T, Yugawa K, Kurihara T, Toshima T, Harada N, Hashisako M, Yonemasu H, Fukuzawa K, Oda Y, Mori M.  Impact of Capicua on Pancreatic Cancer Progression.  Ann Surg Oncol  2021  28(6):3198-3207  PubMed ID: 33216264   DOI: 10.1245/s10434-020-09339-z
20018  Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K.  The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model.  J Surg Res  2021  261:351-360  PubMed ID: 33493887   DOI: 10.1016/j.jss.2020.12.046
20025  Sun S, Kim MJ, Dibwe DF, Omar AM, Athikomkulchai S, Phrutivorapongkul A, Okada T, Tsuge K, Toyooka N, Awale S.  Anti-Austerity Activity of Thai Medicinal Plants: Chemical Constituents and Anti-Pancreatic Cancer Activities of Kaempferia parviflora.  Plants (Basel)  2021  10(2)  PubMed ID: 33503922   DOI: 10.3390/plants10020229
20035  Ito N, Yamada M, Morishita K, Nojima S, Motooka K, Sakata N, Asuka T, Otsu R, Takamatsu S, Kamada Y, Mori S, Akita H, Eguchi H, Morii E, Miyoshi E.  Identification of fucosylated haptoglobin-producing cells in pancreatic cancer tissue and its molecular mechanism.  Glycoconj J  2021  38(1):45-54  PubMed ID: 33523362   DOI: 10.1007/s10719-020-09970-8
20094  Sun S, Omar AM, Kim MJ, Phan ND, Chulikhit Y, Awale S.  Chemical constituents of Thai Piper ribesoides and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.  Fitoterapia  2021  104901  PubMed ID: 33794305   DOI: 10.1016/j.fitote.2021.104901
20096  Kurogi S, Hijiya N, Hidano S, Sato S, Uchida T, Tsukamoto Y, Nakada C, Yada K, Hirashita T, Inomata M, Murakami K, Takahashi N, Kobayashi T, Moriyama M.  Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential.  Pathobiology  2021  1-9  PubMed ID: 33794543   DOI: 10.1159/000514593
20099  Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H.  Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.  Anticancer Res  2021  41(4):1733-1744  PubMed ID: 33813377   DOI: 10.21873/anticanres.14938
20164  Sagara A, Nakata K, Yamashita T, Guan W, Zhong P, Matsumoto S, Endo S, Iwamoto C, Shindo K, Ikenaga N, Moriyama T, Ohuchida K, Mizumoto K, Nakamura M.  New high-throughput screening detects compounds that suppress pancreatic stellate cell activation and attenuate pancreatic cancer growth.  Pancreatology  2021    PubMed ID: 33965328   DOI: 10.1016/j.pan.2021.04.002
20167  Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N.  Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential.  Pancreatology  2021  21(3):573-580  PubMed ID: 33541781   DOI: 10.1016/j.pan.2021.01.013
20186  Saito R, Kawaida H, Hosomura N, Amemiya H, Itakura J, Yamamoto A, Takiguchi K, Maruyama S, Shoda K, Furuya S, Akaike H, Kawaguchi Y, Sudo M, Inoue S, Kono H, Ichikawa D.  Exposure to Blood Components and Inflammation Contribute to Pancreatic Cancer Progression.  Ann Surg Oncol  2021    PubMed ID: 34101067   DOI: 10.1245/s10434-021-10250-4
20189  Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S.  Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.  Int J Radiat Oncol Biol Phys  2021    PubMed ID: 34112559   DOI: 10.1016/j.ijrobp.2021.04.001
14512  Ando H, Eshima K, Ishida T.  Neutralization of Acidic Tumor Microenvironment (TME) with Daily Oral Dosing of Sodium Potassium Citrate (K/Na Citrate) Increases Therapeutic Effect of Anti-cancer Agent in Pancreatic Cancer Xenograft Mice Model  Biol Pharm Bull   2021  4(2):266-270  PubMed ID: 33518679   DOI: 10.1248/bpb.b20-00825
20254  Sun S, Kim MJ, Omar AM, Duy Phan N, Aoike M, Awale S.  GDP Induces PANC-1 Human Pancreatic Cancer Cell Death Preferentially under Nutrient Starvation by Inhibiting PI3K/Akt/mTOR/Autophagy Signaling Pathway.  Chem Biodivers  2021    PubMed ID: 34213070   DOI: 10.1002/cbdv.202100389
15289  Yahagi H, Yahagi T, Matsumura M, Igarashi K, Yokoyama N, Matsuzaki K.  Inhibitory activity of flavonoids from Ephedrae Herba on hypoxia signaling in PANC-1 cells and the evaluation of their mechanisms  J Nat Med  2021  75(3):612-622  PubMed ID: 33813664   DOI: 10.1007/s11418-021-01507-z
20431  Shiozaki A, Konishi T, Kosuga T, Kudou M, Kurashima K, Inoue H, Shoda K, Arita T, Konishi H, Morimura R, Komatsu S, Ikoma H, Toma A, Kubota T, Fujiwara H, Okamoto K, Otsuji E.  Roles of voltage‑gated potassium channels in the maintenance of pancreatic cancer stem cells.  Int J Oncol  2021  59(4)  PubMed ID: 34414448   DOI: 10.3892/ijo.2021.5256
20448  Shimasaki T, Yamamoto S, Omura R, Ito K, Nishide Y, Yamada H, Ohtomo K, Ishisaka T, Okano K, Ogawa T, Tsuji H, Matsuo Y, Minamoto T, Tomosugi N, Ferain E, Ochiya T.  Novel Platform for Regulation of Extracellular Vesicles and Metabolites Secretion from Cells Using a Multi-Linkable Horizontal Co-Culture Plate.  Micromachines (Basel)  2021  12(11)  PubMed ID: 34832842   DOI: 10.3390/mi12111431
16171  Harada A, Matsumoto S, Yasumizu Y, Shojima K, Akama T, Eguchi H, Kikuchi A.  Localization of KRAS downstream target ARL4C to invasive pseudopods accelerates pancreatic cancer cell invasion  Elife  2021  10:e66721  PubMed ID: 34590580   DOI: 10.7554/eLife.66721
16214  PRAMOD NEPAL, YUTO HOZAKA, TAKAKO TANAKA, MASUMI WADA, SHUNICHI ASAI, CHIKASHI MINEMURA, TETSUYA IDICHI, TAKAAKI ARIGAMI, HIROSHI KURAHARA, NAOHIKO SEKI, TAKAO OHTSUKA  Impact of Oncogenic Targets Controlled by Tumor-Suppressive miR-30a-5p in Pancreatic Ductal Adenocarcinoma  Anticancer Res  2021  41(10):4821-4836  PubMed ID: 34593431   DOI: 10.21873/anticanres.15297
16522  Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.  Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth  ACS Chem Biol  2021  16(8):1576-1586  PubMed ID: 34296611   DOI: 10.1021/acschembio.1c00480
16701  Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D.  Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly  J Cell Biol  2021  220(2):e202006085  PubMed ID: 33443571   DOI: 10.1083/jcb.202006085
16776  Sijia Sun, Min Jo Kim, Ashraf M. Omar, Nguyen Duy Phan, Suresh Awale  (+)-Panduratin A induces PANC-1 human pancreatic cancer cell death preferentially under nutrient starvation by inhibiting PI3K/Akt/mTOR/autophagy signaling pathway  Phytomedicine Plus  2021  1:100101    DOI: 10.1016/j.phyplu.2021.100101
16777  Liang C, Fukuda T, Isaji T, Duan C, Song W, Wang Y, Gu J.  α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma  Biochim Biophys Acta Gen Subj  2021  1865(6):12987  PubMed ID: 33571582   DOI: 10.1016/j.bbagen.2021.129870
16778  Jinno N, Yoshida M, Hayashi K, Naitoh I, Hori Y, Natsume M, Kato A, Kachi K, Asano G, Atsuta N, Sahashi H, Kataoka H.  Autotaxin in ascites promotes peritoneal dissemination in pancreatic cancer  Cancer Sci  2021  112(2):668-678  PubMed ID: 33053268   DOI: 10.1111/cas.14689
16779  Mang D, Roy SR, Zhang Q, Hu X, Zhang Y.  Heparan Sulfate-Instructed Self-Assembly Selectively Inhibits Cancer Cell Migration  ACS Appl Mater Interfaces  2021  13(15):17236-17242  PubMed ID: 33830729   DOI: 10.1021/acsami.1c00934
11767  Tang R, Kimishima A, Ishida R, Setiawan A, Arai M.  Selective cytotoxicity of epidithiodiketopiperazine DC1149B, produced by marine-derived Trichoderma lixii on the cancer cells adapted to glucose starvation.  J Nat Med  2020  74(1):153-158  PubMed ID: 31435860   DOI: 10.1007/s11418-019-01357-w
11836  Tachikawa M, Kaneko Y, Ohtsuki S, Uchida Y, Watanabe M, Ohtsuka H, Terasaki T.  Targeted Proteomics-Based Quantitative Protein Atlas of Pannexin and Connexin Subtypes in Mouse and Human Tissues and Cancer Cell Lines.  J Pharm Sci  2020  109(2):1161-1168  PubMed ID: 31605689   DOI: 10.1016/j.xphs.2019.09.024
6956  Sato M, Matsumoto M, Saiki Y, Alam M, Nishizawa H, Rokugo M, Brydun A, Yamada S, Kaneko MK, Funayama R, Ito M, Kato Y, Nakayama K, Unno M, Igarashi K.  BACH1 promotes pancreatic cancer metastasis by repressing epithelial genes and enhancing epithelial-mesenchymal transition.  Cancer Res  2020  80(6):1279-1292  PubMed ID: 31919242   DOI: 10.1158/0008-5472.CAN-18-4099
9820  Mai T T Nguyen, Khang D H Nguyen, Phu H Dang, Hai X Nguyen, Suresh Awale 1, Nhan T Nguyen  Calosides A-F, Cardenolides From Calotropis gigantea and Their Cytotoxic Activity  J Nat Prod  2020  83(2):385-391  PubMed ID: 31967821   DOI: 10.1021/acs.jnatprod.9b00875
11920  Takumi Chinen , Shohei Yamamoto, Yutaka Takeda , Koki Watanabe, Kanako Kuroki , Kaho Hashimoto , Daisuke Takao , Daiju Kitagawa  NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells  EMBO J  2020    PubMed ID: 31782546   DOI: 10.15252/embj.2019102378
11941  Alexander BE, Sun S, Palframan MJ, Kociok-Köhn G, Dibwe DF, Watanabe S, Caggiano L, Awale S, Lewis SE.  Sidechain Diversification of Grandifloracin Allows Identification of Analogues with Enhanced Anti-Austerity Activity against Human PANC-1 Pancreatic Cancer Cells.  ChemMedChem  2020    PubMed ID: 31821731   DOI: 10.1002/cmdc.201900549
12029  Tang R, Kimishima A, Setiawan A, Arai M.  Secalonic acid D as a selective cytotoxic substance on the cancer cells adapted to nutrient starvation.  J Nat Med  2020    PubMed ID: 32002808   DOI: 10.1007/s11418-020-01390-0
12081  Noda S, Chikazawa K, Suzuki Y, Imaizumi Y, Yamamura H.  Involvement of the γ1 subunit of the large-conductance Ca2+-activated K+ channel in the proliferation of human somatostatinoma cells.  Biochem. Biophys. Res. Commun.  2020    PubMed ID: 32178873   DOI: 10.1016/j.bbrc.2020.02.176
12159  Ahmed M. Zaher, Jianyu Lin, Masayoshi Arai  Cytotoxic Activity of Abietane-Type Diterpenes Isolated From Taxodium distichum Against Cancer Cells Adapted to Nutrient-Starved Conditions  SAGE Journals  2020      DOI: 10.1177/1934578X20915298
12994  Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y.  Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells.  Oncol Rep  2020    PubMed ID: 32627027   DOI: 10.3892/or.2020.7595
13007  Takenaga K, Akimoto M, Koshikawa N, Nagase H.  Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model.  PLoS One  2020    PubMed ID: 32340025   DOI: 10.1371/journal.pone.0232230
13085  Tang R, Zhou D, Kimishima A, Setiawan A, Arai M.  Selective cytotoxicity of marine-derived fungal metabolite (3S,6S)-3,6-dibenzylpiperazine-2,5-dione against cancer cells adapted to nutrient starvation.  J Antibiot (Tokyo)  2020    PubMed ID: 32587348   DOI: 10.1038/s41429-020-0340-3
13088  Hirashita T, Hirashita Y, Iwashita Y, Endo Y, Kiyonaga M, Matsumoto S, Hijiya N, Moriyama M, Murakami K, Inomata M.  S6 ribosomal protein phosphorylation is associated with malignancy of intraductal papillary mucinous neoplasm of the pancreas.  Ann Gastroenterol Surg  2020    PubMed ID: 33005852   DOI: 10.1002/ags3.12367
13192  Tawila AM, Sun S, Kim MJ, Omar AM, Dibwe DF, Awale S.  A Triterpene Lactone from Callistemon citrinus Inhibits the PANC-1 Human Pancreatic Cancer Cells Viability through Suppression of Unfolded Protein Response.  Chem Biodivers  2020    PubMed ID: 32865330   DOI: 10.1002/cbdv.202000495
13225  Zheng B, Qu J, Ohuchida K, Feng H, Chong SJF, Yan Z, Piao Y, Liu P, Sheng N, Eguchi D, Ohtsuka T, Mizumoto K, Liu Z, Pervaiz S, Gong P, Nakamura M.  LAMA4 upregulation is associated with high liver metastasis potential and poor survival outcome of Pancreatic Cancer.  Theranostics  2020    PubMed ID: 32929348   DOI: 10.7150/thno.47001
13239  Tanaka T, Okada R, Hozaka Y, Wada M, Moriya S, Satake S, Idichi T, Kurahara H, Ohtsuka T, Seki N.  Molecular Pathogenesis of Pancreatic Ductal Adenocarcinoma: Impact of miR-30c-5p and miR-30c-2-3p Regulation on Oncogenic Genes.  Cancers (Basel)  2020    PubMed ID: 32977589   DOI: 10.3390/cancers12102731
13308  Miyata S, Nakamura T, Kitanaka S.  3EZ, 20Ac-ingenol-induced Apoptosis in Chemoresistant Cancers With Cyclin D1 Accumulation.  Anticancer Res  2020    PubMed ID: 33109561   DOI: 10.21873/anticanres.14644
13335  Abdel-Naime WA, Kimishima A, Setiawan A, Fahim JR, Fouad MA, Kamel MS, Arai M.  Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus Aspergillus sp.  Mar Drugs  2020    PubMed ID: 33171814   DOI: 10.3390/md18110555
13450  Haimin Feng, Taiki Moriyama, Kenoki Ohuchida, Nan Sheng, Chika Iwamoto, Koji Shindo, Kengo Shirahane, Naoki Ikenaga, Shuntaro Nagai, Kohei Nakata, Kazuhiro Mizumoto, Masafumi Nakamura  N-acetyl Cysteine Induces Quiescent-like Pancreatic Stellate Cells From an Active State and Attenuates Cancer-stroma Interactions  Journal of Experimental & Clinical Cancer Research  2020      DOI: 10.21203/rs.3.rs-89408/v1
13611  Ando Y, Ohuchida K, Otsubo Y, Kibe S, Takesue S, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Oda Y, Nakamura M.  Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5  PLoS One  2020  15(1):e0228015  PubMed ID: 31999765   DOI: 10.1371/journal.pone.0228015
13621  Yahagi H, Yahagi T, Furukawa M, Matsuzaki K.  Antiproliferative and Antimigration Activities of Beauvericin Isolated from Isaria sp. on Pancreatic Cancer Cells  Molecules  2020  25(19):4586  PubMed ID: 33050002   DOI: 10.3390/molecules25194586
13837  Machihara K, Namba T.  Kuanoniamine C stimulates bortezomib-induced cell death via suppression of glucose-regulated protein 78 in osteosarcoma  Biochem Biophys Res Commun  2020  527(1):289-296  PubMed ID: 32446382   DOI: 10.1016/j.bbrc.2020.04.109
14801  Takeda Y, Yamazaki K, Hashimoto K, Watanabe K, Chinen T, Kitagawa D.  The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression  J Cell Sci  2020  133(19):jcs241281  PubMed ID: 32878946   DOI: 10.1242/jcs.241281
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
11190  Okumura T, Ohuchida K, Kibe S, Iwamoto C, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Sada M, Horioka K, Mochidome N, Arita M, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M.  Adipose tissue-derived stromal cells are sources of cancer-associated fibroblasts and enhance tumor progression by dense collagen matrix.  Int. J. Cancer  2019  144(6):1401-1413  PubMed ID: 30152542   DOI: 10.1002/ijc.31775
11218  Arima K, Ohmuraya M, Miyake K, Koiwa M, Uchihara T, Izumi D, Gao F, Yonemura A, Bu L, Okabe H, Imai K, Hashimoto D, Baba Y, Chikamoto A, Yamashita YI, Furukawa T, Araki K, Baba H, Ishimoto T.  Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas.  Oncogene  2019  38(8):1211-1224  PubMed ID: 30250298   DOI: 10.1038/s41388-018-0510-y
11436  Yan Z, Ohuchida K, Zheng B, Okumura T, Takesue S, Nakayama H, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M.  CD110 promotes pancreatic cancer progression and its expression is correlated with poor prognosis.  J. Cancer Res. Clin. Oncol.  2019    PubMed ID: 30770989   DOI: 10.1007/s00432-019-02860-z
11483  Khalid M, Idichi T, Seki N, Wada M, Yamada Y, Fukuhisa H, Toda H, Kita Y, Kawasaki Y, Tanoue K, Kurahara H, Mataki Y, Maemura K, Natsugoe S.  Gene Regulation by Antitumor miR-204-5p in Pancreatic Ductal Adenocarcinoma: The Clinical Significance of Direct RACGAP1 Regulation.  Cancers (Basel)  2019    PubMed ID: 30866526   DOI: 10.3390/cancers11030327
11480  Fukuhisa H, Seki N, Idichi T, Kurahara H, Yamada Y, Toda H, Kita Y, Kawasaki Y, Tanoue K, Mataki Y, Maemura K, Natsugoe S.  Gene regulation by antitumor miR-130b-5p in pancreatic ductal adenocarcinoma: the clinical significance of oncogenic EPS8.  J. Hum. Genet.  2019    PubMed ID: 30858505   DOI: 10.1038/s10038-019-0584-6
5027  Nishizawa N1, Harada H1, Kumamoto Y1, Kaizu T, Katoh H, Tajima H, Ushiku H, Yokoi K, Igarashi K, Fujiyama Y, Okuwaki K, Iwai T, Watanabe M, Yamashita K1  Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer.  Cancer Sci  2019  110(9):2846-2855  PubMed ID: 31325200   DOI: 10.1111/cas.14134
11571  Nakayama H, Ohuchida K, Yonenaga A, Sagara A, Ando Y, Kibe S, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Shido K, Miyoshi K, Nakata K, Moriyama T, Miyasaka Y, Inoue S, Ohtsuka T, Mizumoto K, Nakamura M.  S100P regulates the collective invasion of pancreatic cancer cells into the lymphatic endothelial monolayer.  Int. J. Oncol.  2019    PubMed ID: 31180531   DOI: 10.3892/ijo.2019.4812
11575  Yan Z, Ohuchida K, Fei S, Zheng B, Guan W, Feng H, Kibe S, Ando Y, Koikawa K, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Mizumoto K, Hashizume M, Nakamura M.  Inhibition of ERK1/2 in cancer-associated pancreatic stellate cells suppresses cancer-stromal interaction and metastasis.  J. Exp. Clin. Cancer Res.  2019    PubMed ID: 31133044   DOI: 10.1186/s13046-019-1226-8
11779  Zhao H, Jiang X, Duan L, Yang L, Wang W, Ren Z.  Liraglutide suppresses the metastasis of PANC-1 co-cultured with pancreatic stellate cells through modulating intracellular calcium content.  Endocr. J.  2019    PubMed ID: 31474673   DOI: 10.1507/endocrj.EJ19-0215
11811  Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP.  Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.  Cancers (Basel)  2019  11(9):1372  PubMed ID: 31527446   DOI: 10.3390/cancers11091372
11851  Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.  Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.  Sci Rep  2019    PubMed ID: 31611630   DOI: 10.1038/s41598-019-51462-9
6913  Kumaramangalam Jeyalakshmi, et al  Highly active copper(I) complexes of aroylthiourea ligands against cancer cells – synthetic and biological studies  New J Chem  2019  43:3188    DOI: 10.1039/C8NJ04246B
9414  Yoshihito Osugi, Katsumi Fumoto 1, Akira Kikuchi 2  CKAP4 Regulates Cell Migration via the Interaction With and Recycling of Integrin  Mol Cell Biol  2019  39(16):e00073-19  PubMed ID: 31160493   DOI: 10.1128/MCB.00073-19
11906  Kawase A, Inoue Y, Hirosoko M, Sugihara Y, Shimada H, Iwaki M.  Decrease in Multidrug Resistance-associated Protein 2 Activities by Knockdown of Phosphatidylinositol 4-phosphate 5-kinase in Hepatocytes and Cancer Cells.  J Pharm Pharm Sci  2019    PubMed ID: 31804920   DOI: 10.18433/jpps30444
11940  Shiratori R, Furuichi K, Yamaguchi M, Miyazaki N, Aoki H, Chibana H, Ito K, Aoki S.  Glycolytic suppression dramatically changes the intracellular metabolic profile of multiple cancer cell lines in a mitochondrial metabolism-dependent manner.  Sci Rep  2019    PubMed ID: 31822748   DOI: 10.1038/s41598-019-55296-3
10563  Koikawa K, Ohuchida K, Takesue S, Ando Y, Kibe S, Nakayama H, Endo S, Abe T, Okumura T, Horioka K, Sada M, Iwamoto C, Moriyama T, Nakata K, Miyasaka Y, Ohuchida R, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.  Pancreatic stellate cells reorganize matrix components and lead pancreatic cancer invasion via the function of Endo180.  Cancer Lett.  2018  412:143-154  PubMed ID: 29061505   DOI: 10.1016/j.canlet.2017.10.010
11140  Akimoto M, Maruyama R, Kawabata Y, Tajima Y, Takenaga K.  Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.  Cell Death Dis  2018  9(8):804  PubMed ID: 30038429   DOI: 10.1038/s41419-018-0851-z
4453  Idichi T, Seki N, Kurahara H, Fukuhisa H, Toda H, Shimonosono M, Yamada Y, Arai T, Kita Y, Kijima Y, Mataki Y, Maemura K, Natsugoe S.  Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p.  Oncotarget  2018  9(48):28849-28865  PubMed ID: 29988949   DOI: 10.18632/oncotarget.25599
4216  Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.  Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction.  Cell Commun. Signal  2018    PubMed ID: 30180849   DOI: 10.1186/s12964-018-0262-x
4314  Katase N, Nishimatsu SI, Yamauchi A, Yamamura M, Terada K, Itadani M, Okada N, Hassan NMM, Nagatsuka H, Ikeda T, Nohno T, Fujita S.  DKK3 Overexpression Increases the Malignant Properties of Head and Neck Squamous Cell Carcinoma Cells.  Oncol. Res.  2018    PubMed ID: 28470144   DOI: 10.3727/096504017X14926874596386
4382  Kavatsurwa SM, Lombe BK, Feineis D, Dibwe DF, Maharaj V, Awale S, Bringmann G.  Ancistroyafungines A-D, 5,8'- and 5,1'-coupled naphthylisoquinoline alkaloids from a Congolese Ancistrocladus species, with antiausterity activities against human PANC-1 pancreatic cancer cells.  Fitoterapia  2018    PubMed ID: 30059720   DOI: 10.1016/j.fitote.2018.07.017
4383  Akimoto T, Umemura M, Nagasako A, Ohtake M, Fujita T, Yokoyama U, Eguchi H, Yamamoto T, Ishikawa Y.  Alternating magnetic field enhances cytotoxicity of Compound C.  Cancer Sci.  2018  109(11):3483-3493  PubMed ID: 30155931   DOI: 10.1111/cas.13781
4481  Blaise Kimbadi Lombe, Doris Feineis, Virima Mudogo, Reto Brun, Suresh Awale and Gerhard Bringmann  Michellamines A6 and A7, and further mono- and dimeric naphthylisoquinoline alkaloids from a Congolese Ancistrocladus liana and their antiausterity activities against pancreatic cancer cells  RSC Adv  2018  8:5243    DOI: 10.1039/c8ra00363g
4494  Inoko K, Hiraoka K, Inagaki A, Takahashi M, Kushibiki T, Hontani K, Takano H, Sato S, Takeuchi S, Nakamura T, Tsuchikawa T, Shichinohe T, Gruber HE, Jolly DJ, Kasahara N, Hirano S.  Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer.  Cancer Gene Ther.  2018  25(7-8):184-195  PubMed ID: 29735994   DOI: 10.1038/s41417-018-0020-7
5802  Eguchi T et al  Organoids with cancer stem cell-like properties secrete exosomes and HSP90 in a 3D nanoenvironment.  PLoS One  2018  13(2):e0191109.  PubMed ID: 29415026   DOI: 10.1371/journal.pone.0191109
15051  Sun S, Phrutivorapongkul A, Dibwe DF, Balachandran C, Awale S.  Chemical Constituents of Thai Citrus hystrix and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line  J Nat Prod  2018  81(8):1877-1883  PubMed ID: 30070833   DOI: 10.1021/acs.jnatprod.8b00405
15052  Fayez S, Feineis D, Aké Assi L, Kaiser M, Brun R, Awale S, Bringmann G.  Ancistrobrevines E-J and related naphthylisoquinoline alkaloids from the West African liana Ancistrocladus abbreviatus with inhibitory activities against Plasmodium falciparum and PANC-1 human pancreatic cancer cells  Fitoterapia  2018  131:245-259  PubMed ID: 30419265   DOI: 10.1016/j.fitote.2018.11.006
9761  Arai M, Shin D, Kamiya K, Ishida R, Setiawan A, Kotoku N, Kobayashi M.  Marine spongean polybrominated diphenyl ethers, selective growth inhibitors against the cancer cells adapted to glucose starvation, inhibits mitochondrial complex II.  J Nat Med  2017  71:44-49  PubMed ID: 27449332   DOI: 10.1007/s11418-016-1025-x
9958  Kumazoe M, Takai M, Bae J, Hiroi S, Huang Y, Takamatsu K, Won Y, Yamashita M, Hidaka S, Yamashita S, Yamada S, Murata M, Tsukamoto S, Tachibana H.  FOXO3 is essential for CD44 expression in pancreatic cancer cells.  Oncogene  2017  36:2643-2654  PubMed ID: 27893718   DOI: 10.1038/onc.2016.426
10046  Abe T, Ohuchida K, Koikawa K, Endo S, Okumura T, Sada M, Horioka K, Zheng B, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.  Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination.  Int. J. Oncol.  2017  50:457-467  PubMed ID: 28035373   DOI: 10.3892/ijo.2016.3829
10053  Sivakumar B, Aswathy RG, Romero-Aburto R, Mitcham T, Mitchel KA, Nagaoka Y, Bouchard RR, Ajayan PM, Maekawa T, Sakthikumar DN.  Highly versatile SPION encapsulated PLGA nanoparticles as photothermal ablators of cancer cells and as multimodal imaging agents.  Biomater Sci  2017  5:432-443  PubMed ID: 28059418   DOI: 10.1039/c6bm00621c
10086  Nguyen NT, Nguyen MT, Nguyen HX, Dang PH, Dibwe DF, Esumi H, Awale S.  Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.  J. Nat. Prod.  2017  80:141-148  PubMed ID: 28099006   DOI: 10.1021/acs.jnatprod.6b00784
10311  Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Kangawa K, Tachibana H.  The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma.  J. Biol. Chem.  2017  292:10813-10823  PubMed ID: 28507102   DOI: 10.1074/jbc.M116.772111
10337  Iwata T, Uchino T, Koyama A, Johmura Y, Koyama K, Saito T, Ishiguro S, Arikawa T, Komatsu S, Miyachi M, Sano T, Nakanishi M, Shimada M.  The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy.  PLoS ONE  2017  12:e0178221  PubMed ID: 28558031   DOI: 10.1371/journal.pone.0178221
10399  Fujita M, Hasegawa A, Yamamori M, Okamura N.  In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer.  J. Exp. Clin. Cancer Res.  2017  36:91  PubMed ID: 28673319   DOI: 10.1186/s13046-017-0557-6
10448  Arai MA, Utsumi T, Yanase N, Fujimatsu T, Ishibashi M.  Efficient Synthesis of Heterocyclic Flavonoids with Hedgehog Signal Inhibitory Activity.  Chem. Pharm. Bull.  2017  65:784-795  PubMed ID: 28768932   DOI: 10.1248/cpb.c17-00305
10481  Endo S, Nakata K, Sagara A, Koikawa K, Ando Y, Kibe S, Takesue S, Nakayama H, Abe T, Okumura T, Moriyama T, Miyasaka Y, Ohuchida K, Ohtsuka T, Mizumoto K, Nakamura M.  Autophagy inhibition enhances antiproliferative effect of salinomycin in pancreatic cancer cells.  Pancreatology  2017  17:990-996  PubMed ID: 28927939   DOI: 10.1016/j.pan.2017.08.009
10537  Kawamura D, Takemoto Y, Nishimoto A, Ueno K, Hosoyama T, Shirasawa B, Tanaka T, Kugimiya N, Harada E, Hamano K.  Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells.  Oncol. Rep.  2017  38:3238-3244  PubMed ID: 29048622   DOI: 10.3892/or.2017.5974
11010    Ancistrolikokines E–H and related 5,8′-coupled naphthylisoquinoline alkaloids from the Congolese liana Ancistrocladus likoko with antiausterity activities against PANC-1 human pancreatic cancer cells  RSC Adv.  2017  7, 53740-53751    DOI: 10.1039/C7RA11200A
5446  Endo S1, Nakata K2, Ohuchida K3, Takesue S1, Nakayama H1, Abe T1, Koikawa K, Okumura T, Sada M, Horioka K, Zheng B, Mizuuchi Y, Iwamoto C5, Murata M, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Hashizume M, Nakamura M  Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.  Gastroenterology  2017  152(6):1492-1506  PubMed ID: 28126348   DOI: 10.1053/j.gastro.2017.01.010
9171  Haruhiko Fuwa, Mizuho Sato  A Synthetic Analogue of Neopeltolide, 8,9-Dehydroneopeltolide, Is a Potent Anti-Austerity Agent Against Starved Tumor Cells  Mar Drugs  2017  15 (10)  PubMed ID: 29053565   DOI: 10.3390/md15100320
14191  Li J, Seupel R, Bruhn T, Feineis D, Kaiser M, Brun R, Mudogo V, Awale S, Bringmann G.  Jozilebomines A and B, Naphthylisoquinoline Dimers from the Congolese Liana Ancistrocladus ileboensis, with Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Cell Line  J Nat Prod  2017  80(10):2807-2817  PubMed ID: 29043798   DOI: 10.1021/acs.jnatprod.7b00650
14206  Nguyen HX, Nguyen MTT, Nguyen NT, Awale S.  Chemical Constituents of Propolis from Vietnamese Trigona minor and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line  J Nat Prod  2017  80(8):2345-2352  PubMed ID: 28783356   DOI: 10.1021/acs.jnatprod.7b00375
14225  Kumazoe M, Takai M, Hiroi S, Takeuchi C, Yamanouchi M, Nojiri T, Onda H, Bae J, Huang Y, Takamatsu K, Yamashita S, Yamada S, Kangawa K, Takahashi T, Tanaka H, Tachibana H.  PDE3 inhibitor and EGCG combination treatment suppress cancer stem cell properties in pancreatic ductal adenocarcinoma  Sci Rep  2017  7(1):1917.  PubMed ID: 28507327   DOI: 10.1038/s41598-017-02162-9
14244  Idichi T, Seki N, Kurahara H, Yonemori K, Osako Y, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S.  Regulation of actin-binding protein ANLN by antitumor miR-217 inhibits cancer cell aggressiveness in pancreatic ductal adenocarcinoma  Oncotarget  2017  8(32):53180-53193  PubMed ID: 28881803   DOI: 10.18632/oncotarget.18261
14251  Yonemori K, Seki N, Idichi T, Kurahara H, Osako Y, Koshizuka K, Arai T, Okato A, Kita Y, Arigami T, Mataki Y, Kijima Y, Maemura K, Natsugoe S.  The microRNA expression signature of pancreatic ductal adenocarcinoma by RNA sequencing: anti-tumour functions of the microRNA-216 cluster  Oncotarget  2017  8(41):70097-70115  PubMed ID: 29050264   DOI: 10.18632/oncotarget.19591
14252  Maki T, Ikeda H, Kuroda A, Kyogoku N, Yamamura Y, Tabata Y, Abiko T, Tsuchikawa T, Hida Y, Shichinohe T, Tanaka E, Kaga K, Hatanaka K, Matsuno Y, Imai N, Hirano S.  Differential detection of cytoplasmic Wilms tumor 1 expression by immunohistochemistry, western blotting and mRNA quantification  Int J Oncol  2017  50(1):129-140.  PubMed ID: 27922671   DOI: 10.3892/ijo.2016.3786
14378  Yonemori K, Seki N, Kurahara H, Osako Y, Idichi T, Arai T, Koshizuka K, Kita Y, Maemura K, Natsugoe S.  ZFP36L2 promotes cancer cell aggressiveness and is regulated by antitumor microRNA-375 in pancreatic ductal adenocarcinoma  Cancer Sci  2017  108(1):124-135  PubMed ID: 27862697   DOI: 10.1111/cas.13119
14616  Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H.  Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression  Oncotarget  2017  8(7):12290-12300  PubMed ID: 28103577   DOI: 10.18632/oncotarget.14703
14655  Ohishi T, Yoshida H, Katori M, Migita T, Muramatsu Y, Miyake M, Ishikawa Y, Saiura A, Iemura SI, Natsume T, Seimiya H.  Tankyrase-Binding Protein TNKS1BP1 Regulates Actin Cytoskeleton Rearrangement and Cancer Cell Invasion  Cancer Res  2017  77(9):2328-2338  PubMed ID: 28202517   DOI: 10.1158/0008-5472.CAN-16-1846
14681  Inaguma S, Wang Z, Lasota J, Onda M, Czapiewski P, Langfort R, Rys J, Szpor J, Waloszczyk P, Okoń K, Biernat W, Ikeda H, Schrump DS, Hassan R, Pastan I, Miettinen M.  Comprehensive immunohistochemical study of mesothelin (MSLN) using different monoclonal antibodies 5B2 and MN-1 in 1562 tumors with evaluation of its prognostic value in malignant pleural mesothelioma  Oncotarget  2017  8(16):26744-26754  PubMed ID: 28460459   DOI: 10.18632/oncotarget.15814
14726  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E.  Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer  Sci Rep  2017  7(1):5708  PubMed ID: 28720759   DOI: 10.1038/s41598-017-06137-8
14948  Inoue K, Ohtsuka H, Tachikawa M, Motoi F, Shijo M, Douchi D, Kawasaki S, Kawaguchi K, Masuda K, Fukase K, Naitoh T, Katayose Y, Egawa S, Unno M, Terasaki T.  MK2461, a Multitargeted Kinase Inhibitor, Suppresses the Progression of Pancreatic Cancer by Disrupting the Interaction Between Pancreatic Cancer Cells and Stellate Cells  Pancreas  2017  46(4):557-566  PubMed ID: 28196027   DOI: 10.1097/MPA.0000000000000778
9568  Chijiiwa Y, Moriyama T, Ohuchida K, Nabae T, Ohtsuka T, Miyasaka Y, Fujita H, Maeyama R, Manabe T, Abe A, Mizuuchi Y, Oda Y, Mizumoto K, Nakamura M.  Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL.  Int. J. Oncol.  2016  48:1688-700  PubMed ID: 26892887   DOI: 10.3892/ijo.2016.3389
9592  Hijiya N, Tsukamoto Y, Nakada C, Tung Nguyen L, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.  Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.  Cancer Res.  2016  76:2612-25  PubMed ID: 26941286   DOI: 10.1158/0008-5472.CAN-15-1846
9624  Itonaga M, Matsuzaki I, Warigaya K, Tamura T, Shimizu Y, Fujimoto M, Kojima F, Ichinose M, Murata S.  Novel Methodology for Rapid Detection of KRAS Mutation Using PNA-LNA Mediated Loop-Mediated Isothermal Amplification.  PLoS ONE  2016  11:e0151654  PubMed ID: 26999437   DOI: 10.1371/journal.pone.0151654
9748  Arai M, Kamiya K, Shin D, Matsumoto H, Hisa T, Setiawan A, Kotoku N, Kobayashi M.  N-Methylniphatyne A, a New 3-Alkylpyridine Alkaloid as an Inhibitor of the Cancer Cells Adapted to Nutrient Starvation, from an Indonesian Marine Sponge of Xestospongia sp.  Chem. Pharm. Bull.  2016  64:766-71  PubMed ID: 27373630   DOI: 10.1248/cpb.c16-00118
9938  Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S.  CASTIN: a system for comprehensive analysis of cancer-stromal interactome.  BMC Genomics  2016  17:899  PubMed ID: 27829362   DOI: 10.1186/s12864-016-3207-z
10031  Hasebe F, Matsuda K, Shiraishi T, Futamura Y, Nakano T, Tomita T, Ishigami K, Taka H, Mineki R, Fujimura T, Osada H, Kuzuyama T, Nishiyama M.  Amino-group carrier-protein-mediated secondary metabolite biosynthesis in Streptomyces.  Nat. Chem. Biol.  2016  12:967-972  PubMed ID: 28288097   DOI: 10.1038/nchembio.2181
12659  Mohammad GH, Olde Damink SW, Malago M, Dhar DK, Pereira SP.  Pyruvate Kinase M2 and Lactate Dehydrogenase A Are Overexpressed in Pancreatic Cancer and Correlate with Poor Outcome  PLoS One  2016  11(3):e0151635  PubMed ID: 26989901   DOI: 10.1371/journal.pone.0151635
12907  Sada M, Ohuchida K, Horioka K, Okumura T, Moriyama T, Miyasaka Y, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M.  Hypoxic stellate cells of pancreatic cancer stroma regulate extracellular matrix fiber organization and cancer cell motility  Cancer Lett  2016  372(2):210-8  PubMed ID: 26805763   DOI: 10.1016/j.canlet.2016.01.016
14122  Nguyen HX, Do TN, Le TH, Nguyen MT, Nguyen NT, Esumi H, Awale S.  Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line  J Nat Prod  2016  79(8):2053-9  PubMed ID: 27466882   DOI: 10.1021/acs.jnatprod.6b00381
7168  Miyamae M, Komatsu S, Ichikawa D, Kawaguchi T, Hirajima S, Okajima W, Ohashi T, Imamura T, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E.  Plasma microRNA profiles: identification of miR-744 as a novel diagnostic and prognostic biomarker in pancreatic cancer.  Br. J. Cancer  2015  113:1467-76  PubMed ID: 26505678   DOI: 10.1038/bjc.2015.366
7235  Tsukahara T, Haniu H, Matsuda Y.  The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells.  Biores Open Access  2015  4:319-25  PubMed ID: 26309807   DOI: 10.1089/biores.2015.0018
7318  Douchi D, Ohtsuka H, Ariake K, Masuda K, Kawasaki S, Kawaguchi K, Fukase K, Oikawa M, Motoi F, Naitoh T, Katayose Y, Egawa S, Unno M.  Silencing of LRRFIP1 reverses the epithelial-mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway.  Cancer Lett.  2015  365:132-40  PubMed ID: 26047573   DOI: 10.1016/j.canlet.2015.05.023
7331  Sakai S, Inamoto K, Ashida T, Takamura R, Taya M.  Cancer stem cell marker-expressing cell-rich spheroid fabrication from PANC-1 cells using alginate microcapsules with spherical cavities templated by gelatin microparticles.  Biotechnol. Prog.  2015  31:1071-6  PubMed ID: 26013961   DOI: 10.1002/btpr.2111
7358  Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K.  Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death.  PLoS ONE  2015  10:e0126605  PubMed ID: 25961833   DOI: 10.1371/journal.pone.0126605
7400  Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.  Clinical significance of CD155 expression in human pancreatic cancer.  Anticancer Res.  2015  35:2287-97  PubMed ID: 25862891  
7560  Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K  Standard WT1 Expression Using Immunohistochemistry.  J Mol Biomark Diagn  2015  7:266    DOI: 10.4172/2155-9929.1000266
5019  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  SU11274 suppresses proliferation and motility of pancreatic cancer cells.  Oncol Lett  2015  10(3):1468-1472  PubMed ID: 26622692   DOI: 10.3892/ol.2015.3452
5025  Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H.  Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer.  Cancer Sci  2015  106(9):1153-62  PubMed ID: 26132727   DOI: 10.1111/cas.12732
15017  Mizuuchi Y, Aishima S, Ohuchida K, Shindo K, Fujino M, Hattori M, Miyazaki T, Mizumoto K, Tanaka M, Oda Y.  Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition  Lab Invest  2015  95(2):193-206  PubMed ID: 25418581   DOI: 10.1038/labinvest.2014.138
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
15225  Uetaki M, Tabata S, Nakasuka F, Soga T, Tomita M.  Metabolomic alterations in human cancer cells by vitamin C-induced oxidative stress  Sci Rep  2015  5:13896  PubMed ID: 26350063   DOI: 10.1038/srep13896
5018  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Frizzled-2: A potential novel target for molecular pancreatic cancer therapy.  Oncol Lett  2014  7(1):74-78  PubMed ID: 24348824   DOI: 10.3892/ol.2013.1681
13762  Fukuda N, Tsuchikawa T, Fukunaga A, Kawase H, Homma N, Nakamura T, Shichinohe T, Hirano S.  Validation of histological diagnostic methods for detecting endothelin B receptor expression  Oncol Rep  2014  31(4):1561-6  PubMed ID: 24549269   DOI: 10.3892/or.2014.3031
16020  Nguyen MT, Nguyen NT, Nguyen KD, Dau HT, Nguyen HX, Dang PH, Le TM, Nguyen Phan TH, Tran AH, Nguyen BD, Ueda JY, Awale S.  Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity  Planta Med  2014  80(2-3):193-200  PubMed ID: 24431013   DOI: 10.1055/s-0033-1360181
16038  Lale SV, R G A, Aravind A, Kumar DS, Koul V.  AS1411 aptamer and folic acid functionalized pH-responsive ATRP fabricated pPEGMA-PCL-pPEGMA polymeric nanoparticles for targeted drug delivery in cancer therapy  Biomacromolecules  2014  15(5):1737-5  PubMed ID: 24689987   DOI: 10.1021/bm5001263
17133  Liu Y, Sakai S, Kawa S, Taya M.  Identification of hydrogen peroxide-secreting cells by cytocompatible coating with a hydrogel membrane  Anal Chem  2014  86(23):11592-8  PubMed ID: 25359398   DOI: 10.1021/ac503342k
5024  Kawaguchi T, Komatsu S, Ichikawa D, Morimura R, Tsujiura M, Konishi H, Takeshita H, Nagata H, Arita T, Hirajima S, Shiozaki A, Ikoma H, Okamoto K, Ochiai T, Taniguchi H, Otsuji E.  Clinical impact of circulating miR-221 in plasma of patients with pancreatic cancer.  Br J Cancer  2013  108(2):361-9  PubMed ID: 23329235   DOI: 10.1038/bjc.2012.546
3714  Kato N, Yamamoto H, Adachi Y, Ohashi H, Taniguchi H, Suzuki H, Nakazawa M, Kaneto H, Sasaki S, Imai K, Shinomura Y.  Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids.  World J Gastroenterol  2013  19(11):1718-27  PubMed ID: 23555160   DOI: 10.3748/wjg.v19.i11.1718
5020  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  nsulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media.  J Cell Biochem  2012  113(8):2714-20  PubMed ID: 22441995   DOI: 10.1002/jcb.24149
5032  Igarashi S, Matsubara T, Harada K, Ikeda H, Sato Y, Sasaki M, Matsui O, Nakanuma Y.  Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis.  Histopathology  2012  61(2):266-76  PubMed ID: 22594685   DOI: 10.1111/j.1365-2559.2012.04218.x
12868  Yoshida M, Takimoto R, Murase K, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.  Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach  PLoS One  2012  7(7):e39545  PubMed ID: 22808043   DOI: 10.1371/journal.pone.0039545
16079  Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y.  PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis  Cancer Res  2012  72(18):4829-39  PubMed ID: 22826605   DOI: 10.1158/0008-5472.CAN-12-0328
7643  Morimura R, Komatsu S, Ichikawa D, Takeshita H, Tsujiura M, Nagata H, Konishi H, Shiozaki A, Ikoma H, Okamoto K, Ochiai T, Taniguchi H, Otsuji E.  Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer.  Br. J. Cancer  2011  105:1733-40  PubMed ID: 22045190   DOI: 10.1038/bjc.2011.453
7858  Xu H, Inagaki Y, Seyama Y, Hasegawa K, Sugawara Y, Du G, Wang F, Tang W, Kokudo N.  Expression of KL-6/MUC1 in pancreatic ductal carcinoma and its potential relationship with β-catenin in tumor progression.  Life Sci.  2011  88:1063-9  PubMed ID: 21466814   DOI: 10.1016/j.lfs.2011.03.021
7928  Shoji Y, Miyamoto M, Ishikawa K, Yoshioka T, Mishra R, Ichinokawa K, Matsumura Y, Itoh T, Shinohara T, Hirano S, Kondo S.  The CD40-CD154 interaction would correlate with proliferation and immune escape in pancreatic ductal adenocarcinoma.  J Surg Oncol  2011  103:230-8  PubMed ID: 21337550   DOI: 10.1002/jso.21812
7984  Tomita Y, Imai K, Senju S, Irie A, Inoue M, Hayashida Y, Shiraishi K, Mori T, Daigo Y, Tsunoda T, Ito T, Nomori H, Nakamura Y, Kohrogi H, Nishimura Y.  A novel tumor-associated antigen, cell division cycle 45-like can induce cytotoxic T-lymphocytes reactive to tumor cells.  Cancer Sci.  2011  102:697-705  PubMed ID: 21231984   DOI: 10.1111/j.1349-7006.2011.01865.x
3711  Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H.  Hepatocyte growth factor activator inhibitor type 1 suppresses metastatic pulmonary colonization of pancreatic carcinoma cells.  Cancer Sci  2011  102(2):407-13  PubMed ID: 21166957   DOI: 10.1111/j.1349-7006.2010.01808.x
12860  Trono JD, Mizuno K, Yusa N, Matsukawa T, Yokoyama K, Uesaka M.  Size, concentration and incubation time dependence of gold nanoparticle uptake into pancreas cancer cells and its future application to X-Ray Drug Delivery System  J Radiat Res  2011  52(1):103-9.  PubMed ID: 21187668   DOI: 10.1269/jrr.10068
15725  Inaguma S, Kasai K, Ikeda H.  GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin  Oncogene  2011  30(6):714-23  PubMed ID: 20972463   DOI: 10.1038/onc.2010.459
16753  Arai MA, Tateno C, Koyano T, Kowithayakorn T, Kawabe S, Ishibashi M.  New hedgehog/GLI-signaling inhibitors from Adenium obesum  Org Biomol Chem  2011  9(4):1133-9  PubMed ID: 21170436   DOI: 10.1039/c0ob00677g
8292  Iseki H, Takeda A, Andoh T, Takahashi N, Kurochkin IV, Yarmishyn A, Shimada H, Okazaki Y, Koyama I.  Human Arm protein lost in epithelial cancers, on chromosome X 1 (ALEX1) gene is transcriptionally regulated by CREB and Wnt/beta-catenin signaling.  Cancer Sci.  2010  101:1361-6  PubMed ID: 20398052   DOI: 10.1111/j.1349-7006.2010.01541.x
8294  Tomizawa M, Shinozaki F, Sugiyama T, Yamamoto S, Sueishi M, Yoshida T.  Insulin-like growth factor-I receptor in proliferation and motility of pancreatic cancer.  World J. Gastroenterol.  2010  16:1854-8  PubMed ID: 20397262   DOI: 10.3748/wjg.v16.i15.1854
5875  Mishra R, Miyamoto M, Yoshioka T, Ishikawa K, Matsumura Y, Shoji Y, Ichinokawa K, Itoh T, Shichinohe T, Hirano S, Kondo S.  Adenovirus-mediated eukaryotic initiation factor 4E binding protein-1 in combination with rapamycin inhibits tumor growth of pancreatic ductal adenocarcinoma in vivo.  Int J Oncol  2009  34(5):1231-40  PubMed ID: 19360336  
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
12297  Michiko Harao, Shinya Hirata, Atsushi Irie, Satoru Senju, Tetsuya Nakatsura, Hiroyuki Komori, Yoshiaki Ikuta, Kazunori Yokomine, Katsunori Imai, Mitsuhiro Inoue, Kumiko Harada, Takeshi Mori, Takuya Tsunoda, Shuichi Nakatsuru, Yataro Daigo, Hiroaki Nomori, Yusuke Nakamura, Hideo Baba, Yasuharu Nishimura  HLA-A2-restricted CTL epitopes of a novel lung cancer-associated cancer testis antigen, cell division cycle associated 1, can induce tumor-reactive CTL  Int J Cancer  2008  123(11):2616-25  PubMed ID: 18770861   DOI: 10.1002/ijc.23823
15602  Guleng B, Tateishi K, Ohta M, Asaoka Y, Jazag A, Lin LJ, Tanaka Y, Tada M, Seto M, Kanai F, Kawabe T, Omata M.  Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity  J Gastroenterol   2006  41(12):1238-9  PubMed ID: 17287906   DOI: 10.1007/s00535-006-1955-2



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