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19818
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RB1 loss induces quiescent state through downregulation of RAS signaling in mammary epithelial cells
Cancer Sci
2024
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PubMed ID: 38468443
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Ando S, Tanaka K, Matsumoto M, Oyama Y, Tomabechi Y, Yamagata A, Shirouzu M, Nakagawa R, Okimoto N, Taiji M, Sato K, Ohama T.
The luciferase-based in vivo protein-protein interaction assay revealed that CHK1 promotes PP2A and PME-1 interaction.
J Biol Chem
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GFPT2 expression is induced by gemcitabine administration and enhances invasion by activating the hexosamine biosynthetic pathway in pancreatic cancer
Clin Exp Metastasis
2024
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21903
Yamazaki T, Phan ND, Maneenet J, Yamagishi M, Nishikawa Y, Okada T, Okumura T, Toyooka N, Fujii T, Awale S.
Targeting Pancreatic Cancer with Novel Nicolaioidesin C Derivatives: Molecular Mechanism, In Vitro, and In Vivo Evaluations.
J Med Chem
2024
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RASEF/Rab45 regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells.
Biochim Biophys Acta Mol Basis Dis
2024
1870(7):167310
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18161
Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Nogawa T, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Dohmae N, Osada H.
Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling
Oncol Res
2023
31(6):833-844
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Blockage of retinoic acid signaling via RARγ suppressed the proliferation of pancreatic cancer cells by arresting the cell cycle progression of the G1-S phase
Cancer Cell Int
2023
23(1):94
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18286
Amada K, Hijiya N, Ikarimoto S, Yanagihara K, Hanada T, Hidano S, Kurogi S, Tsukamoto Y, Nakada C, Kinoshita K, Hirashita Y, Uchida T, Shin T, Yada K, Hirashita T, Kobayashi T, Murakami K, Inomata M, Shirao K, Aoki M, Takekawa M, Moriyama M.
Involvement of clusterin expression in the refractory response of pancreatic cancer cells to a MEK inhibitor
Cancer Sci
2023
114(5):2189-2202
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19617
Kashiwagi R, Funayama R, Aoki S, Matsui A, Klein S, Sato Y, Suzuki T, Murakami K, Inoue K, Iseki M, Masuda K, Mizuma M, Naito H, Duda DG, Unno M, Nakayama K.
Collagen XVII regulates tumor growth in pancreatic cancer through interaction with the tumor microenvironment
Cancer Sci
2023
114(11):4286-4298
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19743
Mana Hosobuchi, Jun Kataoka, Hiromu Yokokawa, You Okazaki, Ryoichi Hirayama, Taku Inaniwa, Masashi Ueda, Mitsuhiro Kimura
Experimental verification of efficacy of pBCT in terms of physical and biological aspects
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
2023
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19960
Nakano M, Sakamoto T, Kitano Y, Bono H, Simpson RJ, Tabunoki H.
An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types
BMC Genomics
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24(1):735
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J Nat Prod
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A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy.
Cell Rep Med
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21185
Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S.
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.
Drug Deliv
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21234
Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N.
Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation.
J Med Chem
2023
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Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M.
Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma.
Cancer Res
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Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)
ACS Chem Biol
2022
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Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.
PLoS One
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Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models
Br J Cancer
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Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.
Br J Cancer
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New Theonellapeptolides from Indonesian Marine Sponge Theonella swinhoei as Anti-Austerity Agents
Mar Drugs
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Kawatani M, Aono H, Shimizu T, Ohkura S, Hiranuma S, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Yamazaki K, Dan S, Osada H.
Identification of Dihydroorotate Dehydrogenase Inhibitors─Indoluidins─That Inhibit Cancer Cell Growth
ACS Chem Biol
2021
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Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K.
The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model.
J Surg Res
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Anticancer Res
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Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential.
Pancreatology
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Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.
Int J Radiat Oncol Biol Phys
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Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells.
Cell Rep
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36(1):109311
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Fujisawa N, Takanohashi M, Chen L, Uto K, Matsumoto Y, Takeuchi M, Ebara M.
A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy.
Sci Technol Adv Mater
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LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence
Transl Oncol
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Kariya Y, Oyama M, Kariya Y, Hashimoto Y.
Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.
Biomolecules
2021
11(9)
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Daikuzono H, Yamazaki M, Sato Y, Takahashi T, Yamagata K.
Development of a DELFIA method to detect oncofetal antigen ROR1-positive exosomes.
Biochem Biophys Res Commun
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Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S.
In silico-labeled ghost cytometry
Elife
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Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.
Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth
ACS Chem Biol
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α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma
Biochim Biophys Acta Gen Subj
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Molecular and Functional Analysis of Choline Transporters and Antitumor Effects of Choline Transporter-Like Protein 1 Inhibitors in Human Pancreatic Cancer Cells
Int J Mol Sci
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Furuhashi S, Sakaguchi T, Murakami T, Fukushima M, Morita Y, Ikegami K, Kikuchi H, Setou M, Takeuchi H.
Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma
Pancreas
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49(3):442-454
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Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.
Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.
Cell Chem Biol
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An ultra-stable cytoplasmic antibody engineered for in vivo applications.
Nat Commun
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miR-3940-5p/miR-8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma.
Oncol Lett
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Oncol Rep
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Sci Rep
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Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.
Sci Rep
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Fuchigami T, Ishikawa N, Nozaki I, Miyanari Y, Yoshida S, Yamauchi M, Soejima A, Haratake M, Nakayama M.
Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin
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Experimental validation of stochastic microdosimetric kinetic model for multi-ion therapy treatment planning with helium-, carbon-, oxygen-, and neon-ion beams
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Cancer Sci
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Cancer Sci
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Anal Sci
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