CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2094 : MIA Paca2]

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5086 Shieh JH, Cini JK, Wu MC, Yunis AA. Purification and characterization of human colony-stimulating factor 1 from human pancreatic carcinoma (MIA PaCa-2) cells. Arch Biochem Biophys 1987 253(1):205-13 PubMed ID: 3545083 DOI: 10.1016/0003-9861(87)90653-9

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5085 Ziboh VA, Wong T, Wu MC, Yunis AA. Modulation of colony stimulating factor-induced murine myeloid colony formation by S-peptido-lipoxygenase products. Cancer Res 1986 46(2):600-3 PubMed ID: 3079666

5081 Fountzilas G, Gratzner H, Lim LO, Yunis AA. Sensitivity of cultured human pancreatic carcinoma cells to dihydroxyanthracenedione. Int J Cancer 1984 33(3):347-53 PubMed ID: 6698638 DOI: 10.1002/ijc.2910330311

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5077 Wu MC, Arimura GK, Yunis AA. Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase. Int J Cancer 1978 22(6):728-33 PubMed ID: 363626 DOI: 10.1002/ijc.2910220615

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5076 Wu M, Arimura GK, Yunis AA. Purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells. Biochemistry 1977 16(9):1908-13 PubMed ID: 15590 DOI: 10.1021/bi00628a023

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21107 Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S. Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model. J Nat Prod 2023 PubMed ID: 36938707 DOI: 10.1021/acs.jnatprod.3c00019

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21299 Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M. Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma. Cancer Res 2023 OF1-OF12 PubMed ID: 37378549 DOI: 10.1158/0008-5472.CAN-22-3762

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16498 Nakayama A, Nagashima T, Nishizono Y, Kuramoto K, Mori K, Homboh K, Yuri M, Shimazaki M. Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models Br J Cancer 2022 126(5):744-753 PubMed ID: 34795410 DOI: 10.1038/s41416-021-01629-x

20976 Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H. Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer. Br J Cancer 2022 PubMed ID: 36536047 DOI: 10.1038/s41416-022-02106-9

20018 Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K. The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model. J Surg Res 2021 261:351-360 PubMed ID: 33493887 DOI: 10.1016/j.jss.2020.12.046

20099 Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H. Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells. Anticancer Res 2021 41(4):1733-1744 PubMed ID: 33813377 DOI: 10.21873/anticanres.14938

20167 Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N. Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential. Pancreatology 2021 21(3):573-580 PubMed ID: 33541781 DOI: 10.1016/j.pan.2021.01.013

20189 Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S. Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer. Int J Radiat Oncol Biol Phys 2021 PubMed ID: 34112559 DOI: 10.1016/j.ijrobp.2021.04.001

20223 Yanagi K, Komatsu T, Ogihara S, Okabe T, Kojima H, Nagano T, Ueno T, Hanaoka K, Urano Y. Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells. Cell Rep 2021 36(1):109311 PubMed ID: 34233188 DOI: 10.1016/j.celrep.2021.109311

20307 Fujisawa N, Takanohashi M, Chen L, Uto K, Matsumoto Y, Takeuchi M, Ebara M. A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy. Sci Technol Adv Mater 2021 22(1):522-531 PubMed ID: 34220340 DOI: 10.1080/14686996.2021.1939152

15490 Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H. LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence Transl Oncol 2021 14(11):101212 PubMed ID: 34461558 DOI: 10.1016/j.tranon.2021.101212

20367 Kariya Y, Oyama M, Kariya Y, Hashimoto Y. Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility. Biomolecules 2021 11(9) PubMed ID: 34572536 DOI: 10.3390/biom11091323

15921 Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S. In silico-labeled ghost cytometry Elife 2021 10:e67660 PubMed ID: 34930522 DOI: 10.7554/eLife.67660

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16777 Liang C, Fukuda T, Isaji T, Duan C, Song W, Wang Y, Gu J. α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma Biochim Biophys Acta Gen Subj 2021 1865(6):12987 PubMed ID: 33571582 DOI: 10.1016/j.bbagen.2021.129870

6918 Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H. Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA. Cell Chem Biol 2020 27(2):186-196 PubMed ID: 31813846 DOI: 10.1016/j.chembiol.2019.11.010

12005 Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K. An ultra-stable cytoplasmic antibody engineered for in vivo applications. Nat Commun 2020 PubMed ID: 31953402 DOI: 10.1038/s41467-019-13654-9

12994 Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y. Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells. Oncol Rep 2020 PubMed ID: 32627027 DOI: 10.3892/or.2020.7595

13007 Takenaga K, Akimoto M, Koshikawa N, Nagase H. Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model. PLoS One 2020 PubMed ID: 32340025 DOI: 10.1371/journal.pone.0232230

13122 Ono Y, Hayashi A, Maeda C, Suzuki M, Wada R, Sato H, Kawabata H, Okada T, Goto T, Karasaki H, Mizukami Y, Okumura T. Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR. Sci Rep 2020 PubMed ID: 32704002 DOI: 10.1038/s41598-020-69221-6

13290 Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H. Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential. Sci Rep 2020 PubMed ID: 33060804 DOI: 10.1038/s41598-020-74590-z

13611 Ando Y, Ohuchida K, Otsubo Y, Kibe S, Takesue S, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Oda Y, Nakamura M. Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5 PLoS One 2020 15(1):e0228015 PubMed ID: 31999765 DOI: 10.1371/journal.pone.0228015

13764 Fuchigami T, Ishikawa N, Nozaki I, Miyanari Y, Yoshida S, Yamauchi M, Soejima A, Haratake M, Nakayama M. Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin Cancer Sci 2020 111(4):1357-1366 PubMed ID: 31991041 DOI: 10.1111/cas.14330

14838 Inaniwa T, Suzuki M, Hyun Lee S, Mizushima K, Iwata Y, Kanematsu N, Shirai T. Experimental validation of stochastic microdosimetric kinetic model for multi-ion therapy treatment planning with helium-, carbon-, oxygen-, and neon-ion beams Phys Med Biol 2020 65(4):045005 PubMed ID: 31968318 DOI: 10.1088/1361-6560/ab6eba

11358 Kibe S, Ohuchida K, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Okumura T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Shimamoto M, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M. Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion. Cancer Lett. 2019 PubMed ID: 30590101 DOI: 10.1016/j.canlet.2018.12.005

5027 Nishizawa N1, Harada H1, Kumamoto Y1, Kaizu T, Katoh H, Tajima H, Ushiku H, Yokoi K, Igarashi K, Fujiyama Y, Okuwaki K, Iwai T, Watanabe M, Yamashita K1 Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer. Cancer Sci 2019 110(9):2846-2855 PubMed ID: 31325200 DOI: 10.1111/cas.14134

5030 Tsukamoto M, Imai K, Ishimoto T, Komohara Y, Yamashita YI, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Miyata T, Arima K, Okabe H, Baba Y, Chikamoto A, Ishiko T, Hirota M, Baba H. PD-L1 expression enhancement by infiltrating macrophage-derived tumor necrosis factor-α leads to poor pancreatic cancer prognosis. Cancer Sci 2019 110(1):310-320 PubMed ID: 30426611 DOI: 10.1111/cas.13874

11811 Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP. Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer. Cancers (Basel) 2019 11(9):1372 PubMed ID: 31527446 DOI: 10.3390/cancers11091372

11851 Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T. Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction. Sci Rep 2019 PubMed ID: 31611630 DOI: 10.1038/s41598-019-51462-9

6913 Kumaramangalam Jeyalakshmi, et al Highly active copper(I) complexes of aroylthiourea ligands against cancer cells – synthetic and biological studies New J Chem 2019 43:3188 DOI: 10.1039/C8NJ04246B

11140 Akimoto M, Maruyama R, Kawabata Y, Tajima Y, Takenaga K. Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis. Cell Death Dis 2018 9(8):804 PubMed ID: 30038429 DOI: 10.1038/s41419-018-0851-z

4453 Idichi T, Seki N, Kurahara H, Fukuhisa H, Toda H, Shimonosono M, Yamada Y, Arai T, Kita Y, Kijima Y, Mataki Y, Maemura K, Natsugoe S. Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p. Oncotarget 2018 9(48):28849-28865 PubMed ID: 29988949 DOI: 10.18632/oncotarget.25599

11242 Johzuka J, Ona T, Nomura M. One Hour In Vivo-like Phenotypic Screening System for Anti-cancer Drugs Using a High Precision Surface Plasmon Resonance Device. Anal Sci 2018 PubMed ID: 30305596 DOI: 10.2116/analsci.18P013

4298 Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M. Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro. Cancer Sci. 2018 PubMed ID: 29902349 DOI: 10.1111/cas.13694

10092 Doi T, Ishikawa T, Okayama T, Oka K, Mizushima K, Yasuda T, Sakamoto N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Naito Y, Itoh Y. The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines. Oncol. Rep. 2017 37:1545-1554 PubMed ID: 28112370 DOI: 10.3892/or.2017.5399

10128 Koya T, Yanagisawa R, Higuchi Y, Sano K, Shimodaira S. Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity. Sci Rep 2017 7:42145 PubMed ID: 28191816 DOI: 10.1038/srep42145

10228 Yamauchi A, Yamamura M, Katase N, Itadani M, Okada N, Kobiki K, Nakamura M, Yamaguchi Y, Kuribayashi F. Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device. BMC Cancer 2017 17:234 PubMed ID: 28359316 DOI: 10.1186/s12885-017-3218-4

10399 Fujita M, Hasegawa A, Yamamori M, Okamura N. In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer. J. Exp. Clin. Cancer Res. 2017 36:91 PubMed ID: 28673319 DOI: 10.1186/s13046-017-0557-6

10537 Kawamura D, Takemoto Y, Nishimoto A, Ueno K, Hosoyama T, Shirasawa B, Tanaka T, Kugimiya N, Harada E, Hamano K. Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells. Oncol. Rep. 2017 38:3238-3244 PubMed ID: 29048622 DOI: 10.3892/or.2017.5974

5430 Li C, Imai M, Yamasaki M, Hasegawa S, Takahashi N. Effects of Pre- and Post-Administration of Vitamin A on the Growth of Refractory Cancers in Xenograft Mice. Biol Pharm Bull 2017 40(4):486-494 PubMed ID: 28100867 DOI: 10.1248/bpb.b16-00933

14616 Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H. Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression Oncotarget 2017 8(7):12290-12300 PubMed ID: 28103577 DOI: 10.18632/oncotarget.14703

14688 Ono Y, Sugitani A, Karasaki H, Ogata M, Nozaki R, Sasajima J, Yokochi T, Asahara S, Koizumi K, Ando K, Hironaka K, Daito T, Mizukami Y. An improved digital polymerase chain reaction protocol to capture low-copy KRAS mutations in plasma cell-free DNA by resolving 'subsampling' issues Mol Oncol 2017 11(10):1448-1458 PubMed ID: 28691390 DOI: 10.1002/1878-0261.12110

14726 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E. Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer Sci Rep 2017 7(1):5708 PubMed ID: 28720759 DOI: 10.1038/s41598-017-06137-8

9592 Hijiya N, Tsukamoto Y, Nakada C, Tung Nguyen L, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M. Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma. Cancer Res. 2016 76:2612-25 PubMed ID: 26941286 DOI: 10.1158/0008-5472.CAN-15-1846

9938 Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S. CASTIN: a system for comprehensive analysis of cancer-stromal interactome. BMC Genomics 2016 17:899 PubMed ID: 27829362 DOI: 10.1186/s12864-016-3207-z

6235 Li C, Imai M, Matsuura T, Hasegawa S, Yamasaki M, Takahashi N. Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells. Biol Pharm Bull 2016 39(4):636-40 PubMed ID: 26822412 DOI: 10.1248/bpb.b15-00794

7235 Tsukahara T, Haniu H, Matsuda Y. The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells. Biores Open Access 2015 4:319-25 PubMed ID: 26309807 DOI: 10.1089/biores.2015.0018

7243 Yoshino Y, Ishioka C. Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells. Sci Rep 2015 5:13249 PubMed ID: 26292722 DOI: 10.1038/srep13249

7358 Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K. Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death. PLoS ONE 2015 10:e0126605 PubMed ID: 25961833 DOI: 10.1371/journal.pone.0126605

7400 Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y. Clinical significance of CD155 expression in human pancreatic cancer. Anticancer Res. 2015 35:2287-97 PubMed ID: 25862891

7560 Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K Standard WT1 Expression Using Immunohistochemistry. J Mol Biomark Diagn 2015 7:266 DOI: 10.4172/2155-9929.1000266

5019 Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N. SU11274 suppresses proliferation and motility of pancreatic cancer cells. Oncol Lett 2015 10(3):1468-1472 PubMed ID: 26622692 DOI: 10.3892/ol.2015.3452

5025 Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H. Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer. Cancer Sci 2015 106(9):1153-62 PubMed ID: 26132727 DOI: 10.1111/cas.12732

15126 Nakase I, Kobayashi NB, Takatani-Nakase T, Yoshida T. Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes Sci Rep 2015 5:10300 PubMed ID: 26036864 DOI: 10.1038/srep10300

15159 Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y. Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers Proc Natl Acad Sci U S A 2015 112(29):E3816-25 PubMed ID: 26124144 DOI: 10.1073/pnas.1510077112

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