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Cell No. : Cell Name
RCB2094 : MIA Paca2  update : 2023/06/30
CommentHuman cell line derived from pancreatic cancer. TKG0227 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (
Basic information Depositor Obinata, Masuo
Originator Yunis, A
Year of deposit 2005
Original cell TKG0227
Animal _human < Mammals
Genus Homo
Species sapiens
Race Caucasian
Gender Male
Age at sampling 65 years
Tissue pancreas
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0227)
Lifespan infinite
Morphology epithelial-like
Cellosaurus(Expasy) CVCL_0428
deposit info
lot info
Medium Medium List
Culture type Adherent cells
Culture medium DMEM (low glucose) + 10% FBS
Antibiotics Free
Passage method pipetting
Culture information Passage ratio 1 : 8 split
SC frequency Subculture : once/week, Medium Renewal : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
deposit info
lot info
Reference information Reference 14
User's Publication 75

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3301  Yamada T, Okajima F, Ohwada S, Kondo Y  Growth inhibition of human pancreatic cancer cells by sphingosylphosphorylcholine and influence of culture conditions.  Cell Mol Life Sci  1997  53:435-41  PubMed ID: 9176562   DOI: 10.1007/s000180050052
5087  Fountzilas G, Lim LO, Yunis AA.  The inhibitory effects of teniposide and homoharringtonine on the growth of pancreatic carcinoma cells in vitro.  Anticancer Res  1988  8(3):343-6  PubMed ID: 3389738  
5086  Shieh JH, Cini JK, Wu MC, Yunis AA.  Purification and characterization of human colony-stimulating factor 1 from human pancreatic carcinoma (MIA PaCa-2) cells.  Arch Biochem Biophys  1987  253(1):205-13  PubMed ID: 3545083   DOI: 10.1016/0003-9861(87)90653-9
5084  Fountzilas G, Gratzner H, Lim LO, Yunis AA.  Comparative effects of selected drug combinations on the growth of a human pancreatic carcinoma cell line (MIA PaCa-2).  J Natl Cancer Inst  1986  76(1):37-43  PubMed ID: 3455740  
5085  Ziboh VA, Wong T, Wu MC, Yunis AA.  Modulation of colony stimulating factor-induced murine myeloid colony formation by S-peptido-lipoxygenase products.  Cancer Res  1986  46(2):600-3  PubMed ID: 3079666  
5081  Fountzilas G, Gratzner H, Lim LO, Yunis AA.  Sensitivity of cultured human pancreatic carcinoma cells to dihydroxyanthracenedione.  Int J Cancer  1984  33(3):347-53  PubMed ID: 6698638   DOI: 10.1002/ijc.2910330311
5082  Fountzilas G, Lim LO, Yunis AA.  Sensitivity of human pancreatic carcinoma cell line (MIA PaCa-2) to Bisantrene and Theprubicin in vitro.  In Vitro  1984  20(9):685-91  PubMed ID: 6500607   DOI: 10.1007/bf02618873
5083  Yunis AA, Jimenez JJ, Wu MC, Andreotti PE.  Further evidence supporting an in vivo role for colony-stimulating factor.  Exp Hematol  1984  12(11):838-43  PubMed ID: 6334613  
5080  Wu MC, Arimura GK, Holcenberg JS, Yunis AA.  Sensitivity of cultured pancreatic carcinoma cells to Acinetobacter glutaminase-asparaginase.  In Vitro  1982  18(9):750-4  PubMed ID: 7173949   DOI: 10.1007/bf02796498
5079  Allen L, Meck R, Yunis A.  The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).  Res Commun Chem Pathol Pharmacol  1980  27(1):175-82  PubMed ID: 6102405  
5078  Wu M, Cini JK, Yunis AA.  Purification of a colony-stimulating factor from cultured pancreatic carcinoma cells.  J Biol Chem  1979  254(14):6226-8  PubMed ID: 312800  
5077  Wu MC, Arimura GK, Yunis AA.  Mechanism of sensitivity of cultured pancreatic carcinoma to asparaginase.  Int J Cancer  1978  22(6):728-33  PubMed ID: 363626   DOI: 10.1002/ijc.2910220615
3460  Yunis, A A, Arimura, G K, Russin, D J  Human pancreatic carcinoma (MIA PaCa-2) in continuous culture: sensitivity to asparaginase.  Int J Cancer  1977  19:128-35  PubMed ID: 832918   DOI: 10.1002/ijc.2910190118
5076  Wu M, Arimura GK, Yunis AA.  Purification and characterization of a plasminogen activator secreted by cultured human pancreatic carcinoma cells.  Biochemistry  1977  16(9):1908-13  PubMed ID: 15590   DOI: 10.1021/bi00628a023

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User's Publication
21107  Phan ND, Omar AM, Takahashi I, Baba H, Okumura T, Imura J, Okada T, Toyooka N, Fujii T, Awale S.  Nicolaioidesin C: An Antiausterity Agent Shows Promising Antitumor Activity in a Pancreatic Cancer Xenograft Mouse Model.  J Nat Prod  2023    PubMed ID: 36938707   DOI: 10.1021/acs.jnatprod.3c00019
21138  Xie L, Zhang L, Hu K, Hanyu M, Zhang Y, Fujinaga M, Minegishi K, Ohkubo T, Nagatsu K, Jiang C, Shimokawa T, Ashisuke K, Okonogi N, Yamada S, Wang F, Wang R, Zhang MR.  A 211At-labelled mGluR1 inhibitor induces cancer senescence to elicit long-lasting anti-tumor efficacy.  Cell Rep Med  2023    PubMed ID: 37003259   DOI: 10.1016/j.xcrm.2023.100960
21185  Sugimoto Y, Suga T, Umino M, Yamayoshi A, Mukai H, Kawakami S.  Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives.  Drug Deliv  2023  30(1):2191891  PubMed ID: 36964673   DOI: 10.1080/10717544.2023.2191891
21234  Awale S, Baba H, Phan ND, Kim MJ, Maneenet J, Sawaki K, Kanda M, Okumura T, Fujii T, Okada T, Maruyama T, Okada T, Toyooka N.  Targeting Pancreatic Cancer with Novel Plumbagin Derivatives: Design, Synthesis, Molecular Mechanism, In Vitro and In Vivo Evaluation.  J Med Chem  2023    PubMed ID: 37257133   DOI: 10.1021/acs.jmedchem.3c00394
21299  Sekiya S, Fukuda J, Yamamura R, Ooshio T, Satoh Y, Kosuge S, Sato R, Hatanaka KC, Hatanaka Y, Mitsuhashi T, Nakamura T, Matsuno Y, Hirano S, Sonoshita M.  Drosophila Screening Identifies Dual Inhibition of MEK and AURKB as an Effective Therapy for Pancreatic Ductal Adenocarcinoma.  Cancer Res  2023  OF1-OF12  PubMed ID: 37378549   DOI: 10.1158/0008-5472.CAN-22-3762
16170  Yoshioka H, Kawamura T, Muroi M, Kondoh Y, Honda K, Kawatani M, Aono H, Waldmann H, Watanabe N, Osada H.  Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1)  ACS Chem Biol  2022  Feb 7.  PubMed ID: 35128925   DOI: 10.1021/acschembio.2c00028
20717  Yamakawa K, Koyanagi-Aoi M, Uehara K, Masuda A, Yanagimoto H, Toyama H, Fukumoto T, Kodama Y, Aoi T.  Increased expression of SPRR1A is associated with a poor prognosis in pancreatic ductal adenocarcinoma.  PLoS One  2022  17(5)  PubMed ID: 35617311   DOI: 10.1371/journal.pone.0266620
16498  Nakayama A, Nagashima T, Nishizono Y, Kuramoto K, Mori K, Homboh K, Yuri M, Shimazaki M.  Characterisation of a novel KRAS G12C inhibitor ASP2453 that shows potent anti-tumour activity in KRAS G12C-mutated preclinical models  Br J Cancer  2022  126(5):744-753  PubMed ID: 34795410   DOI: 10.1038/s41416-021-01629-x
20976  Liu Z, Hayashi H, Matsumura K, Ogata Y, Sato H, Shiraishi Y, Uemura N, Miyata T, Higashi T, Nakagawa S, Mima K, Imai K, Baba H.  Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer.  Br J Cancer  2022    PubMed ID: 36536047   DOI: 10.1038/s41416-022-02106-9
20018  Odagiri T, Asano Y, Kagiya T, Matsusaki M, Akashi M, Shimoda H, Hakamada K.  The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model.  J Surg Res  2021  261:351-360  PubMed ID: 33493887   DOI: 10.1016/j.jss.2020.12.046
20099  Furuhashi S, Morita Y, Ida S, Muraki R, Kitajima R, Takeda M, Kikuchi H, Hiramatsu Y, Setou M, Takeuchi H.  Ephrin Receptor A4 Expression Enhances Migration, Invasion and Neurotropism in Pancreatic Ductal Adenocarcinoma Cells.  Anticancer Res  2021  41(4):1733-1744  PubMed ID: 33813377   DOI: 10.21873/anticanres.14938
20167  Nakamura K, Sho M, Akahori T, Nishiwada S, Kunishige T, Nakagawa K, Nagai M, Takagi T, Terai T, Ikeda N.  Clinical relevance of CD70 expression in resected pancreatic cancer: Prognostic value and therapeutic potential.  Pancreatology  2021  21(3):573-580  PubMed ID: 33541781   DOI: 10.1016/j.pan.2021.01.013
20189  Suzuki M, Anko M, Ohara M, Matsumoto KI, Hasegawa S.  Radiation-Induced Autophagy in Human Pancreatic Cancer Cells is Critically Dependent on G2 Checkpoint Activation: A Mechanism of Radioresistance in Pancreatic Cancer.  Int J Radiat Oncol Biol Phys  2021    PubMed ID: 34112559   DOI: 10.1016/j.ijrobp.2021.04.001
20223  Yanagi K, Komatsu T, Ogihara S, Okabe T, Kojima H, Nagano T, Ueno T, Hanaoka K, Urano Y.  Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells.  Cell Rep  2021  36(1):109311  PubMed ID: 34233188   DOI: 10.1016/j.celrep.2021.109311
20307  Fujisawa N, Takanohashi M, Chen L, Uto K, Matsumoto Y, Takeuchi M, Ebara M.  A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy.  Sci Technol Adv Mater  2021  22(1):522-531  PubMed ID: 34220340   DOI: 10.1080/14686996.2021.1939152
15490  Bo T, Kobayashi S, Inanami O, Fujii J, Nakajima O, Ito T, Yasui H.  LAT1 inhibitor JPH203 sensitizes cancer cells to radiation by enhancing radiation-induced cellular senescence  Transl Oncol  2021  14(11):101212  PubMed ID: 34461558   DOI: 10.1016/j.tranon.2021.101212
20367  Kariya Y, Oyama M, Kariya Y, Hashimoto Y.  Phosphorylated Osteopontin Secreted from Cancer Cells Induces Cancer Cell Motility.  Biomolecules  2021  11(9)  PubMed ID: 34572536   DOI: 10.3390/biom11091323
15921  Ugawa M, Kawamura Y, Toda K, Teranishi K, Morita H, Adachi H, Tamoto R, Nomaru H, Nakagawa K, Sugimoto K, Borisova E, An Y, Konishi Y, Tabata S, Morishita S, Imai M, Takaku T, Araki M, Komatsu N, Hayashi Y, Sato I, Horisaki R, Noji H, Ota S.  In silico-labeled ghost cytometry  Elife  2021  10:e67660  PubMed ID: 34930522   DOI: 10.7554/eLife.67660
16522  Kawatani M, Aono H, Hiranuma S, Shimizu T, Muroi M, Ogawa N, Ohishi T, Ohba SI, Kawada M, Nogawa T, Okano A, Hashizume D, Osada H.  Identification of a Small-Molecule Glucose Transporter Inhibitor, Glutipyran, That Inhibits Cancer Cell Growth  ACS Chem Biol  2021  16(8):1576-1586  PubMed ID: 34296611   DOI: 10.1021/acschembio.1c00480
16777  Liang C, Fukuda T, Isaji T, Duan C, Song W, Wang Y, Gu J.  α1,6-Fucosyltransferase contributes to cell migration and proliferation as well as to cancer stemness features in pancreatic carcinoma  Biochim Biophys Acta Gen Subj  2021  1865(6):12987  PubMed ID: 33571582   DOI: 10.1016/j.bbagen.2021.129870
6918  Nagasawa I, Muroi M, Kawatani M, Ohishi T, Ohba SI, Kawada M, Osada H.  Identification of a Small Compound Targeting PKM2-Regulated Signaling Using 2D Gel Electrophoresis-Based Proteome-wide CETSA.  Cell Chem Biol  2020  27(2):186-196  PubMed ID: 31813846   DOI: 10.1016/j.chembiol.2019.11.010
12005  Kabayama H, Takeuchi M, Tokushige N, Muramatsu SI, Kabayama M, Fukuda M, Yamada Y, Mikoshiba K.  An ultra-stable cytoplasmic antibody engineered for in vivo applications.  Nat Commun  2020    PubMed ID: 31953402   DOI: 10.1038/s41467-019-13654-9
12994  Yoshida J, Ishikawa T, Endo Y, Matsumura S, Ota T, Mizushima K, Hirai Y, Oka K, Okayama T, Sakamoto N, Inoue K, Kamada K, Uchiyama K, Takagi T, Naito Y, Itoh Y.  Metformin inhibits TGF‑β1‑induced epithelial‑mesenchymal transition and liver metastasis of pancreatic cancer cells.  Oncol Rep  2020    PubMed ID: 32627027   DOI: 10.3892/or.2020.7595
13007  Takenaga K, Akimoto M, Koshikawa N, Nagase H.  Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model.  PLoS One  2020    PubMed ID: 32340025   DOI: 10.1371/journal.pone.0232230
13122  Ono Y, Hayashi A, Maeda C, Suzuki M, Wada R, Sato H, Kawabata H, Okada T, Goto T, Karasaki H, Mizukami Y, Okumura T.  Time-saving method for directly amplifying and capturing a minimal amount of pancreatic tumor-derived mutations from fine-needle aspirates using digital PCR.  Sci Rep  2020    PubMed ID: 32704002   DOI: 10.1038/s41598-020-69221-6
13290  Nakane W, Nakamura H, Nakazato T, Kaminaga N, Nakano M, Sakamoto T, Nishiko M, Bono H, Ogiwara I, Kitano Y, Iwabuchi K, Kinoshita K, Simpson RJ, Tabunoki H.  Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential.  Sci Rep  2020    PubMed ID: 33060804   DOI: 10.1038/s41598-020-74590-z
13611  Ando Y, Ohuchida K, Otsubo Y, Kibe S, Takesue S, Abe T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Ohtsuka T, Oda Y, Nakamura M.  Necroptosis in pancreatic cancer promotes cancer cell migration and invasion by release of CXCL5  PLoS One  2020  15(1):e0228015  PubMed ID: 31999765   DOI: 10.1371/journal.pone.0228015
13764  Fuchigami T, Ishikawa N, Nozaki I, Miyanari Y, Yoshida S, Yamauchi M, Soejima A, Haratake M, Nakayama M.  Discovery of inner centromere protein-derived small peptides for cancer imaging and treatment targeting survivin  Cancer Sci  2020  111(4):1357-1366  PubMed ID: 31991041   DOI: 10.1111/cas.14330
14838  Inaniwa T, Suzuki M, Hyun Lee S, Mizushima K, Iwata Y, Kanematsu N, Shirai T.  Experimental validation of stochastic microdosimetric kinetic model for multi-ion therapy treatment planning with helium-, carbon-, oxygen-, and neon-ion beams  Phys Med Biol  2020  65(4):045005  PubMed ID: 31968318   DOI: 10.1088/1361-6560/ab6eba
11358  Kibe S, Ohuchida K, Ando Y, Takesue S, Nakayama H, Abe T, Endo S, Koikawa K, Okumura T, Iwamoto C, Shindo K, Moriyama T, Nakata K, Miyasaka Y, Shimamoto M, Ohtsuka T, Mizumoto K, Oda Y, Nakamura M.  Cancer-associated acinar-to-ductal metaplasia within the invasive front of pancreatic cancer contributes to local invasion.  Cancer Lett.  2019    PubMed ID: 30590101   DOI: 10.1016/j.canlet.2018.12.005
5027  Nishizawa N1, Harada H1, Kumamoto Y1, Kaizu T, Katoh H, Tajima H, Ushiku H, Yokoi K, Igarashi K, Fujiyama Y, Okuwaki K, Iwai T, Watanabe M, Yamashita K1  Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO1) promoter DNA in pancreatic cancer.  Cancer Sci  2019  110(9):2846-2855  PubMed ID: 31325200   DOI: 10.1111/cas.14134
5030  Tsukamoto M, Imai K, Ishimoto T, Komohara Y, Yamashita YI, Nakagawa S, Umezaki N, Yamao T, Kitano Y, Miyata T, Arima K, Okabe H, Baba Y, Chikamoto A, Ishiko T, Hirota M, Baba H.  PD-L1 expression enhancement by infiltrating macrophage-derived tumor necrosis factor-α leads to poor pancreatic cancer prognosis.  Cancer Sci  2019  110(1):310-320  PubMed ID: 30426611   DOI: 10.1111/cas.13874
11811  Mohammad GH, Vassileva V, Acedo P, Olde Damink SWM, Malago M, Dhar DK, Pereira SP.  Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer.  Cancers (Basel)  2019  11(9):1372  PubMed ID: 31527446   DOI: 10.3390/cancers11091372
11851  Fujitani N, Yoneda A, Takahashi M, Takasawa A, Aoyama T, Miyazaki T.  Silencing of Glutathione S-Transferase Pi Inhibits Cancer Cell Growth via Oxidative Stress Induced by Mitochondria Dysfunction.  Sci Rep  2019    PubMed ID: 31611630   DOI: 10.1038/s41598-019-51462-9
6913  Kumaramangalam Jeyalakshmi, et al  Highly active copper(I) complexes of aroylthiourea ligands against cancer cells – synthetic and biological studies  New J Chem  2019  43:3188    DOI: 10.1039/C8NJ04246B
11140  Akimoto M, Maruyama R, Kawabata Y, Tajima Y, Takenaga K.  Antidiabetic adiponectin receptor agonist AdipoRon suppresses tumour growth of pancreatic cancer by inducing RIPK1/ERK-dependent necroptosis.  Cell Death Dis  2018  9(8):804  PubMed ID: 30038429   DOI: 10.1038/s41419-018-0851-z
4453  Idichi T, Seki N, Kurahara H, Fukuhisa H, Toda H, Shimonosono M, Yamada Y, Arai T, Kita Y, Kijima Y, Mataki Y, Maemura K, Natsugoe S.  Involvement of anti-tumor miR-124-3p and its targets in the pathogenesis of pancreatic ductal adenocarcinoma: direct regulation of ITGA3 and ITGB1 by miR-124-3p.  Oncotarget  2018  9(48):28849-28865  PubMed ID: 29988949   DOI: 10.18632/oncotarget.25599
11242  Johzuka J, Ona T, Nomura M.  One Hour In Vivo-like Phenotypic Screening System for Anti-cancer Drugs Using a High Precision Surface Plasmon Resonance Device.  Anal Sci  2018    PubMed ID: 30305596   DOI: 10.2116/analsci.18P013
4298  Feng R, Morine Y, Ikemoto T, Imura S, Iwahashi S, Saito Y, Shimada M.  Nab-paclitaxel interrupts cancer-stromal interaction through C-X-C motif chemokine 10-mediated interleukin-6 downregulation in vitro.  Cancer Sci.  2018    PubMed ID: 29902349   DOI: 10.1111/cas.13694
10092  Doi T, Ishikawa T, Okayama T, Oka K, Mizushima K, Yasuda T, Sakamoto N, Katada K, Kamada K, Uchiyama K, Handa O, Takagi T, Naito Y, Itoh Y.  The JAK/STAT pathway is involved in the upregulation of PD-L1 expression in pancreatic cancer cell lines.  Oncol. Rep.  2017  37:1545-1554  PubMed ID: 28112370   DOI: 10.3892/or.2017.5399
10128  Koya T, Yanagisawa R, Higuchi Y, Sano K, Shimodaira S.  Interferon-α-inducible Dendritic Cells Matured with OK-432 Exhibit TRAIL and Fas Ligand Pathway-mediated Killer Activity.  Sci Rep  2017  7:42145  PubMed ID: 28191816   DOI: 10.1038/srep42145
10228  Yamauchi A, Yamamura M, Katase N, Itadani M, Okada N, Kobiki K, Nakamura M, Yamaguchi Y, Kuribayashi F.  Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device.  BMC Cancer  2017  17:234  PubMed ID: 28359316   DOI: 10.1186/s12885-017-3218-4
10399  Fujita M, Hasegawa A, Yamamori M, Okamura N.  In vitro and in vivo cytotoxicity of troglitazone in pancreatic cancer.  J. Exp. Clin. Cancer Res.  2017  36:91  PubMed ID: 28673319   DOI: 10.1186/s13046-017-0557-6
10537  Kawamura D, Takemoto Y, Nishimoto A, Ueno K, Hosoyama T, Shirasawa B, Tanaka T, Kugimiya N, Harada E, Hamano K.  Enhancement of cytotoxic effects of gemcitabine by Dclk1 inhibition through suppression of Chk1 phosphorylation in human pancreatic cancer cells.  Oncol. Rep.  2017  38:3238-3244  PubMed ID: 29048622   DOI: 10.3892/or.2017.5974
5430  Li C, Imai M, Yamasaki M, Hasegawa S, Takahashi N.  Effects of Pre- and Post-Administration of Vitamin A on the Growth of Refractory Cancers in Xenograft Mice.  Biol Pharm Bull  2017  40(4):486-494  PubMed ID: 28100867   DOI: 10.1248/bpb.b16-00933
14616  Igarashi T, Araki K, Yokobori T, Altan B, Yamanaka T, Ishii N, Tsukagoshi M, Watanabe A, Kubo N, Handa T, Hosouchi Y, Nishiyama M, Oyama T, Shirabe K, Kuwano H.  Association of RAB5 overexpression in pancreatic cancer with cancer progression and poor prognosis via E-cadherin suppression  Oncotarget  2017  8(7):12290-12300  PubMed ID: 28103577   DOI: 10.18632/oncotarget.14703
14688  Ono Y, Sugitani A, Karasaki H, Ogata M, Nozaki R, Sasajima J, Yokochi T, Asahara S, Koizumi K, Ando K, Hironaka K, Daito T, Mizukami Y.  An improved digital polymerase chain reaction protocol to capture low-copy KRAS mutations in plasma cell-free DNA by resolving 'subsampling' issues  Mol Oncol  2017  11(10):1448-1458  PubMed ID: 28691390   DOI: 10.1002/1878-0261.12110
14726  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Konishi H, Shiozaki A, Morimura R, Ikoma H, Ochiai T, Okamoto K, Taniguchi H, Otsuji E.  Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer  Sci Rep  2017  7(1):5708  PubMed ID: 28720759   DOI: 10.1038/s41598-017-06137-8
9592  Hijiya N, Tsukamoto Y, Nakada C, Tung Nguyen L, Kai T, Matsuura K, Shibata K, Inomata M, Uchida T, Tokunaga A, Amada K, Shirao K, Yamada Y, Mori H, Takeuchi I, Seto M, Aoki M, Takekawa M, Moriyama M.  Genomic Loss of DUSP4 Contributes to the Progression of Intraepithelial Neoplasm of Pancreas to Invasive Carcinoma.  Cancer Res.  2016  76:2612-25  PubMed ID: 26941286   DOI: 10.1158/0008-5472.CAN-15-1846
9938  Komura D, Isagawa T, Kishi K, Suzuki R, Sato R, Tanaka M, Katoh H, Yamamoto S, Tatsuno K, Fukayama M, Aburatani H, Ishikawa S.  CASTIN: a system for comprehensive analysis of cancer-stromal interactome.  BMC Genomics  2016  17:899  PubMed ID: 27829362   DOI: 10.1186/s12864-016-3207-z
6235  Li C, Imai M, Matsuura T, Hasegawa S, Yamasaki M, Takahashi N.  Inhibitory Effects of Retinol Are Greater than Retinoic Acid on the Growth and Adhesion of Human Refractory Cancer Cells.  Biol Pharm Bull  2016  39(4):636-40  PubMed ID: 26822412   DOI: 10.1248/bpb.b15-00794
7235  Tsukahara T, Haniu H, Matsuda Y.  The PTB-Associated Splicing Factor/Peroxisome Proliferator-Activated Receptor Gamma Axis Regulates Autophagosome Formation in Human Pancreatic Cancer Cells.  Biores Open Access  2015  4:319-25  PubMed ID: 26309807   DOI: 10.1089/biores.2015.0018
7243  Yoshino Y, Ishioka C.  Inhibition of glycogen synthase kinase-3 beta induces apoptosis and mitotic catastrophe by disrupting centrosome regulation in cancer cells.  Sci Rep  2015  5:13249  PubMed ID: 26292722   DOI: 10.1038/srep13249
7358  Akimoto M, Iizuka M, Kanematsu R, Yoshida M, Takenaga K.  Anticancer Effect of Ginger Extract against Pancreatic Cancer Cells Mainly through Reactive Oxygen Species-Mediated Autotic Cell Death.  PLoS ONE  2015  10:e0126605  PubMed ID: 25961833   DOI: 10.1371/journal.pone.0126605
7400  Nishiwada S, Sho M, Yasuda S, Shimada K, Yamato I, Akahori T, Kinoshita S, Nagai M, Konishi N, Nakajima Y.  Clinical significance of CD155 expression in human pancreatic cancer.  Anticancer Res.  2015  35:2287-97  PubMed ID: 25862891  
7560  Shimodaira S, Hirabayashi K, Koya T, Higuchi Y, Sano K  Standard WT1 Expression Using Immunohistochemistry.  J Mol Biomark Diagn  2015  7:266    DOI: 10.4172/2155-9929.1000266
5019  Tomizawa M, Shinozaki F, Motoyoshi Y, Sugiyama T, Yamamoto S, Ishige N.  SU11274 suppresses proliferation and motility of pancreatic cancer cells.  Oncol Lett  2015  10(3):1468-1472  PubMed ID: 26622692   DOI: 10.3892/ol.2015.3452
5025  Sakamoto K, Imai K, Higashi T, Taki K, Nakagawa S, Okabe H, Nitta H, Hayashi H, Chikamoto A, Ishiko T, Beppu T, Baba H.  Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer.  Cancer Sci  2015  106(9):1153-62  PubMed ID: 26132727   DOI: 10.1111/cas.12732
15126  Nakase I, Kobayashi NB, Takatani-Nakase T, Yoshida T.  Active macropinocytosis induction by stimulation of epidermal growth factor receptor and oncogenic Ras expression potentiates cellular uptake efficacy of exosomes  Sci Rep  2015  5:10300  PubMed ID: 26036864   DOI: 10.1038/srep10300
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15227  Kiuchi S, Ikeshita S, Miyatake Y, Kasahara M.  Pancreatic cancer cells express CD44 variant 9 and multidrug resistance protein 1 during mitosis  Exp Mol Pathol  2015  98(1):41-6  PubMed ID: 25481101   DOI: 10.1016/j.yexmp.2014.12.001
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