CELL SEARCH SYSTEM -CELL BANK- (RIKEN BRC) [RCB2088 : Kato III]

5075 Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al. Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel. Jpn J Cancer Res 1986 77(9):849-53 PubMed ID: 3095279

5074 Sekiguchi M, Sakakibara K, Fujii G. Establishment of cultured cell lines derived from a human gastric carcinoma. Jpn J Exp Med 1978 48(1):61-8 PubMed ID: 209229

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19553 Fujino H, Sonoda-Fukuda E, Isoda L, Kawabe A, Takarada T, Kasahara N, Kubo S. Retroviral Replicating Vectors Mediated Prodrug Activator Gene Therapy in a Gastric Cancer Model Int J Mol Sci 2023 24(19):14823 PubMed ID: 37834271 DOI: 10.3390/ijms241914823

19679 Zhang J, Fu L, Yasuda-Yoshihara N, Yonemura A, Wei F, Bu L, Hu X, Akiyama T, Kitamura F, Yasuda T, Semba T, Uchihara T, Itoyama R, Yamashita K, Eto K, Iwagami S, Yashiro M, Komohara Y, Baba H, Ishimoto T. IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment Gastric Cancer 2023 26(2):187-202 PubMed ID: 36513910 DOI: 10.1007/s10120-022-01352-3

19955 Morinaga T, Iwatsuki M, Yamashita K, Yasuda-Yoshihara N, Yamane T, Matsumoto C, Harada K, Eto K, Kurashige J, Ishimoto T, Baba Y, Miyamoto Y, Yoshida N, Baba H. Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer Ann Surg Oncol 2023 30(2):1240-1252 PubMed ID: 36149610 DOI: 10.1245/s10434-022-12505-0

21459 Hori N, Tazawa H, Li Y, Okura T, Kikuchi S, Kuroda S, Ohara T, Noma K, Nishizaki M, Urata Y, Kagawa S, Fujiwara T. Intraperitoneal Administration of p53-armed Oncolytic Adenovirus Inhibits Peritoneal Metastasis of Diffuse-type Gastric Cancer Cells. Anticancer Res 2023 43(11):4809-4821 PubMed ID: 37909979 DOI: 10.21873/anticanres.16678

21486 Lou M, Iwatsuki M, Wu X, Zhang W, Matsumoto C, Baba H. Cancer-Associated Fibroblast-Derived IL-8 Upregulates PD-L1 Expression in Gastric Cancer Through the NF-κB Pathway. Ann Surg Oncol 2023 PubMed ID: 38006530 DOI: 10.1245/s10434-023-14586-x

17567 Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E. Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer Cancer Sci 2022 113(6):1984-1998 PubMed ID: 35307915 DOI: 10.1111/cas.15342

20571 Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T. Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer. Gastric Cancer 2022 PubMed ID: 35166958 DOI: 10.1007/s10120-022-01283-z

20600 Xie J, Fu L, Zhang J. Analysis of Influencing Factors on the Occurrence and Development of Gastric Cancer in High-Incidence Areas of Digestive Tract Tumors Based on High Methylation of GPX3 Gene. J Oncol 2022 3094881 PubMed ID: 35069731 DOI: 10.1155/2022/3094881

20627 Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K. Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach. Sci Rep 2022 12(1):5050 PubMed ID: 35322078 DOI: 10.1038/s41598-022-08904-8

20887 Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W. MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target. Theranostics 2022 12(15):6509-6526 PubMed ID: 36185598 DOI: 10.7150/thno.75431

18099 Kato T, Nakamori M, Matsumura S, Nakamura M, Ojima T, Fukuhara H, Ino Y, Todo T, Yamaue H. Oncolytic virotherapy with human telomerase reverse transcriptase promoter regulation enhances cytotoxic effects against gastric cancer Oncol Lett 2021 21(6):490 PubMed ID: 33968206 DOI: 10.3892/ol.2021.12751

13323 Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E. TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer. J Cancer 2021 PubMed ID: 33391428 DOI: 10.7150/jca.47577

13337 Kim S, Ahn JM, Bae WJ, Han JH, Lee D. Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer. Gastric Cancer 2021 24(3):577-588 PubMed ID: 33164142 DOI: 10.1007/s10120-020-01139-4

20002 Yasufuku I, Saigo C, Kito Y, Yoshida K, Takeuchi T. Prognostic significance of LDL receptor-related protein 1B in patients with gastric cancer. J Mol Histol 2021 PubMed ID: 33389427 DOI: 10.1007/s10735-020-09932-2

20005 Iwata Y, Yasufuku I, Saigo C, Kito Y, Takeuchi T, Yoshida K. Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma. J Cancer 2021 12(4):1161-1168 PubMed ID: 33442414 DOI: 10.7150/jca.46765

20098 Tsuji T, Maeda Y, Kita K, Murakami K, Saya H, Takemura H, Inaki N, Oshima M, Oshima H. FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells. Oncogene 2021 PubMed ID: 33795838 DOI: 10.1038/s41388-021-01757-x

20148 Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E. β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer. Sci Rep 2021 11(1):10664 PubMed ID: 34021168 DOI: 10.1038/s41598-021-88982-2

20415 Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T. Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells. Oncol Lett 2021 22(4):735 PubMed ID: 34466148 DOI: 10.3892/ol.2021.12996

16803 Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H. Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells FEBS Open Bio 2021 11(5):1465-1475 PubMed ID: 33773069 DOI: 10.1002/2211-5463.13154

16974 Khwanchanok Mokmued, Bhanuz Dechayont, Pathompong Phuaklee, Chantubpapa Liplung, Harit Muangpoolsawad, Nitra Nuengchamnong, Nuntika Prommee Evaluation of anti-inflammatory, cytotoxic, anti-H. pylori, antioxidant activities, and phytochemical compositions of Shirakiopsis indica (Willd.) Esser ScienceAsia 2021 47:549 DOI: 10.2306/scienceasia1513-1874.2021.068

12030 Yoshizawa N, Sugimoto K, Tameda M, Inagaki Y, Ikejiri M, Inoue H, Usui M, Ito M, Takei Y. miR-3940-5p/miR-8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma. Oncol Lett 2020 PubMed ID: 32218818 DOI: 10.3892/ol.2020.11357

12160 Naranpraphai Suthisamphat, Bhanuz Dechayont , Pathompong Phuaklee , Onmanee Prajuabjinda, Ratha-Korn Vilaichone, Arunporn Itharat, Khwanchanok Mokmued, and Nuntika Prommee Anti- Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans Evidence-Based Complementary and Alternative Medicine 2020 PubMed ID: 32308716 DOI: 10.1155/2020/7576818

13600 Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K. p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers Biochem Biophys Res Commun 2020 529(3):582-589. PubMed ID: 32736677 DOI: 10.1016/j.bbrc.2020.05.168

14832 Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y. Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines Arch Virol 2020 165(1):207-214 PubMed ID: 31776677 DOI: 10.1007/s00705-019-04474-9

14847 Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T. Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance Cancer Res 2020 80(16):3222-3235 PubMed ID: 32605995 DOI: 10.1158/0008-5472.CAN-19-3803

11202 Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E. Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer. Gastric Cancer 2019 PubMed ID: 30191346 DOI: 10.1007/s10120-018-0874-2

11409 Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M. NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells. Oncogene 2019 PubMed ID: 30700829 DOI: 10.1038/s41388-019-0702-0

11733 Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E. Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells. Int. J. Oncol. 2019 PubMed ID: 31432150 DOI: 10.3892/ijo.2019.4853

10444 Yuta Sugiyama, Erika Takahashi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura Inverse correlation between heme synthesis and the Warburg effect in cancer cells bioRxiv 2019 August 30 DOI: 10.1101/753079

10787 Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S. Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models. Br. J. Cancer 2018 118:972-984 PubMed ID: 29527007 DOI: 10.1038/s41416-018-0008-y

10796 Matsuoka K, Nakagawa F, Kobunai T, Takechi T. Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression. Oncotarget 2018 9:13438-13450 PubMed ID: 29568368 DOI: 10.18632/oncotarget.24412

11231 Wang Z, Qu H, Gong W, Liu A. Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer. IUBMB Life 2018 PubMed ID: 30281914 DOI: 10.1002/iub.1934

4049 Taichi Yoshida, Takashi Maruyama, Masatomo Miura, Masahiro Inoue, Koji Fukuda, Kazuhiro Shimazu, Daiki Taguchi, Hiroaki Kanda, Masanobu Oshima, Yoshiharu Iwabuchi, Hiroyuki Shibata Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis Journal of Functional Foods 2018 50:192-200 DOI: 10.1016/j.jff.2018.09.033

11246 Kimura R, Yoneshige A, Hagiyama M, Otani T, Inoue T, Shiraishi N, Yanagihara K, Wakayama T, Ito A. Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: Possible involvement in peritoneal dissemination of signet ring cells. Life Sci. 2018 PubMed ID: 30312702 DOI: 10.1016/j.lfs.2018.10.017

11282 Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H. The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis. Anticancer Res. 2018 PubMed ID: 30396946 DOI: 10.21873/anticanres.12982

4425 Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients PharmaNutrition 2018 6,100-106 DOI: 10.1016/j.phanu.2018.05.003

4190 Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M. Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma. Oncol. Rep. 2018 PubMed ID: 29138864 DOI: 10.3892/or.2017.6093

4304 Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X. Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer. Oncol Lett 2018 PubMed ID: 29805691 DOI: 10.3892/ol.2018.8562

13126 Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K. Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer. Cancer Sci 2018 PubMed ID: 30290054 DOI: 10.1111/cas.13824

14733 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E. Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma Carcinogenesis 2018 39(2):263-271 PubMed ID: 29228320 DOI: 10.1093/carcin/bgx139

10228 Yamauchi A, Yamamura M, Katase N, Itadani M, Okada N, Kobiki K, Nakamura M, Yamaguchi Y, Kuribayashi F. Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device. BMC Cancer 2017 17:234 PubMed ID: 28359316 DOI: 10.1186/s12885-017-3218-4

10258 Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y. ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer. Cancer Lett. 2017 398:52-61 PubMed ID: 28400336 DOI: 10.1016/j.canlet.2017.04.002

10437 Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H. Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70. Oncol. Rep. 2017 38:1500-1506 PubMed ID: 28731175 DOI: 10.3892/or.2017.5844

10552 Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y. Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships. Am. J. Chin. Med. 2017 45:1497-1511 PubMed ID: 29025293 DOI: 10.1142/S0192415X17500811

10586 Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M. The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios. Oncotarget 2017 8:74567-74581 PubMed ID: 29088808 DOI: 10.18632/oncotarget.20209

10686 Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E. Low plasma levels of miR-101 are associated with tumor progression in gastric cancer. Oncotarget 2017 8:106538-106550 PubMed ID: 29290969 DOI: 10.18632/oncotarget.20860

5804 Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26 Oncology Letters 2017 13(1):215-221 PubMed ID: 28123544 DOI: 10.3892/ol.2016.5386

5806 Shiroki T et al Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism. Cancer Sci 2017 108(5):931-940 PubMed ID: 28235245 DOI: 10.1111/cas.13211

9931 Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications Front Physiol 2017 8:997 PubMed ID: 29259558 DOI: 10.3389/fphys.2017.00997

14585 Kikuchi M, Katoh H, Waraya M, Tanaka Y, Ishii S, Tanaka T, Nishizawa N, Yokoi K, Minatani N, Ema A, Kosaka Y, Tanino H, Yamashita K, Watanabe M. Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer Cancer Lett 2017 384:70-78 PubMed ID: 27756570 DOI: 10.1016/j.canlet.2016.10.017

14619 Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E. Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer Oncotarget 2017 8(60):101394-101405 PubMed ID: 29254173 DOI: 10.18632/oncotarget.20736

14737 Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H. Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines Sci Rep 2017 7(1):11127 PubMed ID: 28894280 DOI: 10.1038/s41598-017-11769-x

5815 Tamura F et al RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells. Gastric Cancer 2016 19(1):85-97 PubMed ID: 25532910 DOI: 10.1007/s10120-014-0454-z

6041 Tani R, Hayakawa K, Tanaka S, Shiota K. Linker histone variant H1T targets rDNA repeats. Epigenetics 2016 11(4):288-302 PubMed ID: 27018843 DOI: 10.1080/15592294.2016.1159369

12639 Yamashita K, Kuno A, Matsuda A, Ikehata Y, Katada N, Hirabayashi J, Narimatsu H, Watanabe M. Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer Gastric Cancer 2016 19(2):531-54 PubMed ID: 25840959 DOI: 10.1007/s10120-015-0491-2

12874 Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H. Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients Gastric Cancer 2016 19(3):789-97. PubMed ID: 26472729 DOI: 10.1007/s10120-015-0551-7

12913 Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E. Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells Oncotarget 2016 7(35):56855-56863 PubMed ID: 27487135 DOI: 10.18632/oncotarget.10869

12951 Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H. Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer Oncol Lett 2016 11(2):1026-1034. PubMed ID: 26893686 DOI: 10.3892/ol.2015.4011

7097 Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S. Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia. PLoS ONE 2015 10:e0146026 PubMed ID: 26717566 DOI: 10.1371/journal.pone.0146026

7334 Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H. Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients. Sci Rep 2015 5:10455 PubMed ID: 25994878 DOI: 10.1038/srep10455

5819 Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K. CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer. Cancer Med 2015 4(9):1322-33 PubMed ID: 26077800 DOI: 10.1002/cam4.478

14977 Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y. CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence J Surg Oncol 2015 112(6):622-8 PubMed ID: 26416034 DOI: 10.1002/jso.24056

15000 Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S. DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells PLoS One 2015 10(12):e0145630 PubMed ID: 26695186 DOI: 10.1371/journal.pone.0145630

15037 Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M. Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients Carcinogenesis 2015 36(12):1474-83 PubMed ID: 26420253 DOI: 10.1093/carcin/bgv139

15159 Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y. Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers Proc Natl Acad Sci U S A 2015 112(29):E3816-25 PubMed ID: 26124144 DOI: 10.1073/pnas.1510077112

10870 Waraya M, Yamashita K, Ema A, Katada N, Kikuchi S, Watanabe M. Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype PLoS One 2015 10(10):e0139902 PubMed ID: 26447864 DOI: 10.1371/journal.pone.0139902

17451 Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Hiramoto H, Hamada J, Shoda K, Kawaguchi T, Hirajima S, Nagata H, Fujiwara H, Okamoto K, Otsuji E. Increase in peritoneal recurrence induced by intraoperative hemorrhage in gastrectomy Ann Surg Oncol 2015 22(3):758-64 PubMed ID: 25201501 DOI: 10.1245/s10434-014-4060-4

18176 Sehdev V, Katsha A, Arras J, Peng D, Soutto M, Ecsedy J, Zaika A, Belkhiri A, El-Rifai W. HDM2 regulation by AURKA promotes cell survival in gastric cancer Clin Cancer Res 2014 20(1):76-86 PubMed ID: 24240108 DOI: 10.1158/1078-0432.CCR-13-1187

3916 Okabe S, Okamoto T, Zhao CM, Chen D, Matsui H. Acetic acid induces cell death: an in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines. J Gastroenterol Hepatol 2014 29 Suppl 4:65-9 PubMed ID: 25521736 DOI: 10.1111/jgh.12775

5830 Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I. Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation. PLoS One 2014 9(7):e102831 PubMed ID: 25033286 DOI: 10.1371/journal.pone.0102831

15817 Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G. A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines PLoS One 2014 9(2):e90155 PubMed ID: 24587255 DOI: 10.1371/journal.pone.0090155

16016 Nakamura A, Nakajima G, Okuyama R, Kuramochi H, Kondoh Y, Kanemura T, Takechi T, Yamamoto M, Hayashi K. Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase Gastric Cancer 2014 17(1):188-95 PubMed ID: 23494117 DOI: 10.1007/s10120-013-0249-7

5845 Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K. Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis. PLoS One 2013 8(2):e56766 PubMed ID: 23451082 DOI: 10.1371/journal.pone.0056766

6075 Murakami H, Nakanishi H, Tanaka H, Ito S, Misawa K, Ito Y, Ikehara Y, Kondo E, Kodera Y. Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential. Gastric Cancer 2013 16(1):74-83 PubMed ID: 22450770 DOI: 10.1007/s10120-012-0149-2

15081 Awazu Y, Nakamura K, Mizutani A, Kakoi Y, Iwata H, Yamasaki S, Miyamoto N, Imamura S, Miki H, Hori A. A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities Mol Cancer Ther 2013 12(6):913-24 PubMed ID: 23548264 DOI: 10.1158/1535-7163.MCT-12-1011

15086 Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H. Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells Oncol Rep 2013 29(4):1349-55 PubMed ID: 23354949 DOI: 10.3892/or.2013.2251

5026 Waraya M, Yamashita K, Katoh H, Ooki A, Kawamata H, Nishimiya H, Nakamura K, Ema A, Watanabe M. Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis. BMC Cancer 2012 12:397 PubMed ID: 22958219 DOI: 10.1186/1471-2407-12-397

5848 Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H. Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks. Invest New Drugs 2012 30(4):1352-60 PubMed ID: 21655918 DOI: 10.1007/s10637-011-9699-0

5850 Miyato H, Tsuno NH, Kitayama J. Semaphorin 3C is involved in the progression of gastric cancer. Cancer Sci 2012 103(11):1961-6 PubMed ID: 22924992 DOI: 10.1111/cas.12003

5852 Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H. Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification. Int J Oncol 2012 41(2):551-8 PubMed ID: 22614071 DOI: 10.3892/ijo.2012.1485

5855 Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP. Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging. J Proteome Res 2012 11(12):5736-47 PubMed ID: 23116296 DOI: 10.1021/pr300555y

15742 Peng DF, Hu TL, Schneider BG, Chen Z, Xu ZK, El-Rifai W. Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas PLoS One 2012 7(10):e46214 PubMed ID: 23071548 DOI: 10.1371/journal.pone.0046214

7876 Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K. Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients. Ann. Surg. Oncol. 2011 18:3013-9 PubMed ID: 21409489 DOI: 10.1245/s10434-011-1636-0

7990 Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S. Expression of BMP-7 in human gastric cancer and its clinical significance. Br. J. Cancer 2011 104:714-8 PubMed ID: 21224856 DOI: 10.1038/sj.bjc.6606075

5866 Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K. Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer. Am J Pathol 2011 178(2):515-24 PubMed ID: 21281785 DOI: 10.1016/j.ajpath.2010.10.010

6115 Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S. Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers. Oncol Rep 2011 26(6):1385-92 PubMed ID: 21894439 DOI: 10.3892/or.2011.1450

16307 Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M. Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer BMC Cancer 2011 11:122 PubMed ID: 21466710 DOI: 10.1186/1471-2407-11-122

18757 Kawaguchi K, Etoh T, Suzuki K, Mitui MT, Nishizono A, Shiraishi N, Kitano S. Efficacy of oncolytic reovirus against human gastric cancer with peritoneal metastasis in experimental animal model Int J Oncol 2010 37(6):1433-8 PubMed ID: 21042711 DOI: 10.3892/ijo_00000795

5868 Tsunemi S, Nakanishi T, Fujita Y, Bouras G, Miyamoto Y, Miyamoto A, Nomura E, Takubo T, Tanigawa N. Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer. Oncol Rep 2010 23(4):949-56 PubMed ID: 20204278 DOI: 10.3892/or_00000719

5874 Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC. p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells. Am J Physiol Gastrointest Liver Physiol 2009 297(2):G385-96 PubMed ID: 19541923 DOI: 10.1152/ajpgi.90620.2008

5876 Takaishi S1, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC. Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells. 2009 27(5):1006-20 PubMed ID: 19415765 DOI: 10.1002/stem.30

6410 Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y. Is parainfluenza virus a threatening virus for human cancer cell lines? Hum Cell 2009 22(3):81-4 PubMed ID: 19624309 DOI: 10.1111/j.1749-0774.2009.00071.x

18311 Mitsuoka K, Miyoshi S, Kato Y, Murakami Y, Utsumi R, Kubo Y, Noda A, Nakamura Y, Nishimura S, Tsuji A. Cancer detection using a PET tracer, 11C-glycylsarcosine, targeted to H+/peptide transporter J Nucl Med 2008 49(4):615-22 PubMed ID: 18344442 DOI: 10.2967/jnumed.107.048231

6139 Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y. IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells. Int J Cancer 2008 122(5):1040-6 PubMed ID: 17957782 DOI: 10.1002/ijc.23181

3900 Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E. Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis. Anticancer Res 2008 28(2B):1169-79 PubMed ID: 18505053

3581 Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K. Biologically active triterpenoid saponins from Ardisia japonica. J Nat Prod 2007 70(2):179-87 PubMed ID: 17243725 DOI: 10.1021/np0604681

15600 Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK. Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer Br J Cancer 2007 97(7):895-901 PubMed ID: 17848950 DOI: 10.1038/sj.bjc.6603968

5897 Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M. Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma. Oncology 2006 70(2):126-33 PubMed ID: 16645325 DOI: 10.1159/000093003

3351 Sakakura, Chouhei, Hagiwara, Akeo, Miyagawa, Koji, Nakashima, Susumu, Yoshikawa, Tetsuji, Kin, Shuichi, Nakase, Yuenn, Ito, Kosei, Yamagishi, Hisakazu, Yazumi, Shujiro, Chiba, Tsutomu, Ito, Yoshiaki Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Int J Cancer 2005 113:221-8 PubMed ID: 15386419 DOI: 10.1002/ijc.20551

3167 Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells. Biol Pharm Bull 2005 28:574-9 PubMed ID: 15802789 DOI: 10.1248/bpb.28.574

5919 Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines Yonago Acta medica 2005 48:7–16

12834 Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y. Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori Mol Biol Cell 2005 16(10):4954-66. PubMed ID: 16030249 DOI: 10.1091/mbc.e05-05-0426

16808 Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Röcken C. The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer Int J Oncol 2005 26(1):17-24 PubMed ID: 15586220

13707 Carl-McGrath S, Lendeckel U, Ebert M, Wolter AB, Roessner A, Röcken C. The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer Int J Oncol 2004 25(5):1223-32 PubMed ID: 15492809

17991 Kura T, Takahashi Y, Takayama T, Ban N, Saito T, Kuga T, Niitsu Y. Glutathione S-transferase-pi is secreted as a monomer into human plasma by platelets and tumor cells Biochim Biophys Acta 1996 1292(2):317-23 PubMed ID: 8597579 DOI: 10.1016/0167-4838(95)00216-2