Search
CELL BANK Website

Back Back
Cell No. : Cell Name
RCB2088 : Kato III  update : 2022/10/04
CommentHuman cell line derived from gastric cancer. Signet ring carcinoma. TKG0213 (Deposited from Tohoku Univ.).
Comment from the depositor
Terms and conditionsThere is no restriction regarding use for basic researches. In relation to commercial use and use for patent filing, first of all please contact the RIKEN BRC.
Remarks
Order Form Order Form(C-0005.pdf)   MTA(C-0007.pdf)   MTA(C-0007p.pdf)  
Regarding MTA between user institutions and RIKEN BRC, there are two kinds of MTA, not-for-profit academic purpose (C-XXXX) and for-profit research purpose (C-XXXXp) , depending on the sort of user institutions and the purposes of use. Please use an appropriate MTA(to see). In relation to commercial use and use for patent filing, first of all Please contact RIKEN BRC (cellbank.brc@riken.jp).
Basic information Depositor Obinata, Masuo
Originator Sekiguchi, M.
Year of deposit 2005
Original cell TKG0213
Animal human < Mammals
Genus Homo
Species sapiens
Tissue stomach
Disease name signet ring carcinoma
Classification cancer
History Cell Resource Center for Biomedical Research, Tohoku University(TKG0213)
Lifespan infinite
Morphology other
Cellosaurus(Expasy) CVCL_0371
deposit info
lot info
Medium Medium List
Culture type Adherent/Suspension cells
Medium and additives RPMI1640 + 10% FBS
Antibiotics Free
Passage method 0.25% Trypsin or pipetting
Culture information Passage ratio 1 : 4 split
SC frequency Subculture : 2 times/week
Temperature 37 ℃
CO2 concentration 5 %
Freeze medium Medium + 10% DMSO
Freezing method Slow freezing
Mycoplasma (-)
Isozyme LD, NP
STR(human) OK
Images
deposit info
lot info
Reference information Reference 2
User's Publication 92


To topTop
Reference
5075  Nakatani H, Tahara E, Yoshida T, Sakamoto H, Suzuki T, Watanabe H, Sekiguchi M, Kaneko Y, Sakurai M, Terada M, et al.  Detection of amplified DNA sequences in gastric cancers by a DNA renaturation method in gel.  Jpn J Cancer Res  1986  77(9):849-53  PubMed ID: 3095279  
5074  Sekiguchi M, Sakakibara K, Fujii G.  Establishment of cultured cell lines derived from a human gastric carcinoma.  Jpn J Exp Med  1978  48(1):61-8  PubMed ID: 209229  

To topTop
User's Publication
20571  Fu L, Yonemura A, Yasuda-Yoshihara N, Umemoto T, Zhang J, Yasuda T, Uchihara T, Akiyama T, Kitamura F, Yamashita K, Okamoto Y, Bu L, Wei F, Hu X, Liu Y, Ajani JA, Tan P, Baba H, Ishimoto T.  Intracellular MUC20 variant 2 maintains mitochondrial calcium homeostasis and enhances drug resistance in gastric cancer.  Gastric Cancer  2022    PubMed ID: 35166958   DOI: 10.1007/s10120-022-01283-z
20600  Xie J, Fu L, Zhang J.  Analysis of Influencing Factors on the Occurrence and Development of Gastric Cancer in High-Incidence Areas of Digestive Tract Tumors Based on High Methylation of GPX3 Gene.  J Oncol  2022  3094881  PubMed ID: 35069731   DOI: 10.1155/2022/3094881
20627  Soda T, Gen Y, Terasaki K, Iwai N, Kitaichi T, Dohi O, Taketani H, Seko Y, Umemura A, Nishikawa T, Yamaguchi K, Moriguchi M, Konishi H, Naito Y, Itoh Y, Yasui K.  Loss of KAP3 decreases intercellular adhesion and impairs intracellular transport of laminin in signet ring cell carcinoma of the stomach.  Sci Rep  2022  12(1):5050  PubMed ID: 35322078   DOI: 10.1038/s41598-022-08904-8
20887  Wang Y, Chen H, Liu W, Yan H, Zhang Y, Cheung AHK, Zhang J, Chen B, Liang L, Zhou Z, Wong CC, Wu WKK, Chan MWY, Cheng ASL, Ma BBY, Yu J, Lo KW, To KF, Kang W.  MCM6 is a critical transcriptional target of YAP to promote gastric tumorigenesis and serves as a therapeutic target.  Theranostics  2022  12(15):6509-6526  PubMed ID: 36185598   DOI: 10.7150/thno.75431
13323  Nishibeppu K, Komatsu S, Kiuchi J, Kishimoto T, Takashima Y, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.  TRIM37 contributes to malignant outcomes and CDDP resistance in gastric cancer.  J Cancer  2021    PubMed ID: 33391428   DOI: 10.7150/jca.47577
13337  Kim S, Ahn JM, Bae WJ, Han JH, Lee D.  Quantitation of ligand is critical for ligand-dependent MET signalling activation and determines MET-targeted therapeutic response in gastric cancer.  Gastric Cancer  2021  24(3):577-588  PubMed ID: 33164142   DOI: 10.1007/s10120-020-01139-4
20002  Yasufuku I, Saigo C, Kito Y, Yoshida K, Takeuchi T.  Prognostic significance of LDL receptor-related protein 1B in patients with gastric cancer.  J Mol Histol  2021    PubMed ID: 33389427   DOI: 10.1007/s10735-020-09932-2
20005  Iwata Y, Yasufuku I, Saigo C, Kito Y, Takeuchi T, Yoshida K.  Anti-fibrotic properties of an adiponectin paralog protein, C1q/TNF-related protein 6 (CTRP6), in diffuse gastric adenocarcinoma.  J Cancer  2021  12(4):1161-1168  PubMed ID: 33442414   DOI: 10.7150/jca.46765
20098  Tsuji T, Maeda Y, Kita K, Murakami K, Saya H, Takemura H, Inaki N, Oshima M, Oshima H.  FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells.  Oncogene  2021    PubMed ID: 33795838   DOI: 10.1038/s41388-021-01757-x
20148  Kubo H, Murayama Y, Ogawa S, Matsumoto T, Yubakami M, Ohashi T, Kubota T, Okamoto K, Kamiya M, Urano Y, Otsuji E.  β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer.  Sci Rep  2021  11(1):10664  PubMed ID: 34021168   DOI: 10.1038/s41598-021-88982-2
20415  Ikari N, Serizawa A, Tanji E, Yamamoto M, Furukawa T.  Analysis of RHOA mutations and their significance in the proliferation and transcriptome of digestive tract cancer cells.  Oncol Lett  2021  22(4):735  PubMed ID: 34466148   DOI: 10.3892/ol.2021.12996
16803  Egawa N, Tanaka T, Matsufuji S, Yamada K, Ito K, Kitagawa H, Okuyama K, Kitajima Y, Noshiro H.  Antitumor effects of low-dose tipifarnib on the mTOR signaling pathway and reactive oxygen species production in HIF-1α-expressing gastric cancer cells  FEBS Open Bio  2021  11(5):1465-1475  PubMed ID: 33773069   DOI: 10.1002/2211-5463.13154
16974  Khwanchanok Mokmued, Bhanuz Dechayont, Pathompong Phuaklee, Chantubpapa Liplung, Harit Muangpoolsawad, Nitra Nuengchamnong, Nuntika Prommee  Evaluation of anti-inflammatory, cytotoxic, anti-H. pylori, antioxidant activities, and phytochemical compositions of Shirakiopsis indica (Willd.) Esser  ScienceAsia  2021  47:549    DOI: 10.2306/scienceasia1513-1874.2021.068
12030  Yoshizawa N, Sugimoto K, Tameda M, Inagaki Y, Ikejiri M, Inoue H, Usui M, Ito M, Takei Y.  miR-3940-5p/miR-8069 ratio in urine exosomes is a novel diagnostic biomarker for pancreatic ductal adenocarcinoma.  Oncol Lett  2020    PubMed ID: 32218818   DOI: 10.3892/ol.2020.11357
12160  Naranpraphai Suthisamphat, Bhanuz Dechayont , Pathompong Phuaklee , Onmanee Prajuabjinda, Ratha-Korn Vilaichone, Arunporn Itharat, Khwanchanok Mokmued, and Nuntika Prommee  Anti- Helicobacter pylori, Anti-Inflammatory, Cytotoxic, and Antioxidant Activities of Mace Extracts from Myristica fragrans  Evidence-Based Complementary and Alternative Medicine  2020    PubMed ID: 32308716   DOI: 10.1155/2020/7576818
13600  Sano H, Futamura M, Gaowa S, Kamino H, Nakamura Y, Yamaguchi K, Tanaka Y, Yasufuku I, Nakakami A, Arakawa H, Yoshida K.  p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers  Biochem Biophys Res Commun  2020  529(3):582-589.  PubMed ID: 32736677   DOI: 10.1016/j.bbrc.2020.05.168
14832  Saito S, Kitamura-Muramatsu Y, Komine F, Polat M, Takeshima SN, Takei M, Aida Y.  Absence of bovine leukemia virus proviral DNA in Japanese human blood cell lines and human cancer cell lines  Arch Virol  2020  165(1):207-214  PubMed ID: 31776677   DOI: 10.1007/s00705-019-04474-9
14847  Uchihara T, Miyake K, Yonemura A, Komohara Y, Itoyama R, Koiwa M, Yasuda T, Arima K, Harada K, Eto K, Hayashi H, Iwatsuki M, Iwagami S, Baba Y, Yoshida N, Yashiro M, Masuda M, Ajani JA, Tan P, Baba H, Ishimoto T.  Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance  Cancer Res  2020  80(16):3222-3235  PubMed ID: 32605995   DOI: 10.1158/0008-5472.CAN-19-3803
11202  Shiozaki A, Ariyoshi Y, Iitaka D, Kosuga T, Shimizu H, Kudou M, Konishi T, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Ichikawa D, Otsuji E.  Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer.  Gastric Cancer  2019    PubMed ID: 30191346   DOI: 10.1007/s10120-018-0874-2
11409  Echizen K, Horiuchi K, Aoki Y, Yamada Y, Minamoto T, Oshima H, Oshima M.  NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells.  Oncogene  2019    PubMed ID: 30700829   DOI: 10.1038/s41388-019-0702-0
11733  Shiozaki A, Yamazato Y, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Marunaka Y, Otsuji E.  Effect of low temperature on the regulation of cell volume after hypotonic shock in gastric cancer cells.  Int. J. Oncol.  2019    PubMed ID: 31432150   DOI: 10.3892/ijo.2019.4853
10444  Yuta Sugiyama, Erika Takahashi, Kiwamu Takahashi, Motowo Nakajima, Tohru Tanaka, Shun-ichiro Ogura  Inverse correlation between heme synthesis and the Warburg effect in cancer cells  bioRxiv  2019  August 30    DOI: 10.1101/753079
10787  Shimada S, Akiyama Y, Mogushi K, Ishigami-Yuasa M, Kagechika H, Nagasaki H, Fukamachi H, Yuasa Y, Tanaka S.  Identification of selective inhibitors for diffuse-type gastric cancer cells by screening of annotated compounds in preclinical models.  Br. J. Cancer  2018  118:972-984  PubMed ID: 29527007   DOI: 10.1038/s41416-018-0008-y
10796  Matsuoka K, Nakagawa F, Kobunai T, Takechi T.  Trifluridine/tipiracil overcomes the resistance of human gastric 5-fluorouracil-refractory cells with high thymidylate synthase expression.  Oncotarget  2018  9:13438-13450  PubMed ID: 29568368   DOI: 10.18632/oncotarget.24412
11231  Wang Z, Qu H, Gong W, Liu A.  Up-regulation and tumor-promoting role of SPHK1 were attenuated by miR-330-3p in gastric cancer.  IUBMB Life  2018    PubMed ID: 30281914   DOI: 10.1002/iub.1934
4049  Taichi Yoshida, Takashi Maruyama, Masatomo Miura, Masahiro Inoue, Koji Fukuda, Kazuhiro Shimazu, Daiki Taguchi, Hiroaki Kanda, Masanobu Oshima, Yoshiharu Iwabuchi, Hiroyuki Shibata  Dietary intake of pyrolyzed deketene curcumin inhibits gastric carcinogenesis  Journal of Functional Foods  2018  50:192-200    DOI: 10.1016/j.jff.2018.09.033
11246  Kimura R, Yoneshige A, Hagiyama M, Otani T, Inoue T, Shiraishi N, Yanagihara K, Wakayama T, Ito A.  Expression of cell adhesion molecule 1 in gastric neck and base glandular cells: Possible involvement in peritoneal dissemination of signet ring cells.  Life Sci.  2018    PubMed ID: 30312702   DOI: 10.1016/j.lfs.2018.10.017
11282  Sekino N, Kano M, Matsumoto Y, Sakata H, Murakami K, Toyozumi T, Otsuka R, Yokoyama M, Shiraishi T, Okada K, Kamata T, Ryuzaki T, Matsubara H.  The Antitumor Effects of Metformin on Gastric Cancer In Vitro and on Peritoneal Metastasis.  Anticancer Res.  2018    PubMed ID: 30396946   DOI: 10.21873/anticanres.12982
4425    Curcumin inhibition of the effects of Tip α induced cytokine expression in gastric cancer patients  PharmaNutrition  2018  6,100-106    DOI: 10.1016/j.phanu.2018.05.003
4190  Kurata A, Yamada M, Ohno SI, Inoue S, Hashimoto H, Fujita K, Takanashi M, Kuroda M.  Expression level of microRNA-200c is associated with cell morphology in vitro and histological differentiation through regulation of ZEB1/2 and E-cadherin in gastric carcinoma.  Oncol. Rep.  2018    PubMed ID: 29138864   DOI: 10.3892/or.2017.6093
4304  Zhang N, Xu J, Wang Y, Heng X, Yang L, Xing X.  Loss of opioid binding protein/cell adhesion molecule-like gene expression in gastric cancer.  Oncol Lett  2018    PubMed ID: 29805691   DOI: 10.3892/ol.2018.8562
13126  Gaowa S, Futamura M, Tsuneki M, Kamino H, Tajima JY, Mori R, Arakawa H, Yoshida K.  Possible role of p53/Mieap-regulated mitochondrial quality control as a tumor suppressor in human breast cancer.  Cancer Sci  2018    PubMed ID: 30290054   DOI: 10.1111/cas.13824
14733  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Fujiwara H, Okamoto K, Tsuda H, Otsuji E.  Overexpression of ZRF1 is related to tumor malignant potential and a poor outcome of gastric carcinoma  Carcinogenesis  2018  39(2):263-271  PubMed ID: 29228320   DOI: 10.1093/carcin/bgx139
10228  Yamauchi A, Yamamura M, Katase N, Itadani M, Okada N, Kobiki K, Nakamura M, Yamaguchi Y, Kuribayashi F.  Evaluation of pancreatic cancer cell migration with multiple parameters in vitro by using an optical real-time cell mobility assay device.  BMC Cancer  2017  17:234  PubMed ID: 28359316   DOI: 10.1186/s12885-017-3218-4
10258  Gen Y, Yasui K, Kitaichi T, Iwai N, Terasaki K, Dohi O, Hashimoto H, Fukui H, Inada Y, Fukui A, Jo M, Moriguchi M, Nishikawa T, Umemura A, Yamaguchi K, Konishi H, Naito Y, Itoh Y.  ASPP2 suppresses invasion and TGF-β1-induced epithelial-mesenchymal transition by inhibiting Smad7 degradation mediated by E3 ubiquitin ligase ITCH in gastric cancer.  Cancer Lett.  2017  398:52-61  PubMed ID: 28400336   DOI: 10.1016/j.canlet.2017.04.002
10437  Yanoma T, Ogata K, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Yanai M, Kogure N, Kimura A, Suzuki M, Nakazawa N, Bai T, Oyama T, Asao T, Shirabe K, Kuwano H.  Heat shock-induced HIKESHI protects cell viability via nuclear translocation of heat shock protein 70.  Oncol. Rep.  2017  38:1500-1506  PubMed ID: 28731175   DOI: 10.3892/or.2017.5844
10552  Okubo S, Uto T, Goto A, Tanaka H, Nishioku T, Yamada K, Shoyama Y.  Berberine Induces Apoptotic Cell Death via Activation of Caspase-3 and -8 in HL-60 Human Leukemia Cells: Nuclear Localization and Structure-Activity Relationships.  Am. J. Chin. Med.  2017  45:1497-1511  PubMed ID: 29025293   DOI: 10.1142/S0192415X17500811
10586  Ishii S, Yamashita K, Harada H, Ushiku H, Tanaka T, Nishizawa N, Yokoi K, Washio M, Ema A, Mieno H, Moriya H, Hosoda K, Waraya M, Katoh H, Watanabe M.  The H19-PEG10/IGF2BP3 axis promotes gastric cancer progression in patients with high lymph node ratios.  Oncotarget  2017  8:74567-74581  PubMed ID: 29088808   DOI: 10.18632/oncotarget.20209
10686  Imamura T, Komatsu S, Ichikawa D, Miyamae M, Okajima W, Ohashi T, Kiuchi J, Nishibeppu K, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Otsuji E.  Low plasma levels of miR-101 are associated with tumor progression in gastric cancer.  Oncotarget  2017  8:106538-106550  PubMed ID: 29290969   DOI: 10.18632/oncotarget.20860
5804  Authors: Takashi Okuda Tomohiko Taki Kazuhiro Nishida Yoshiaki Chinen Hisao Nagoshi Chouhei Sakakura Masafumi Taniwaki  Molecular heterogeneity in the novel fusion gene APIP-FGFR2: Diversity of genomic breakpoints in gastric cancer with high-level amplifications at 11p13 and 10q26  Oncology Letters  2017  13(1):215-221  PubMed ID: 28123544   DOI: 10.3892/ol.2016.5386
5806  Shiroki T et al  Enhanced expression of the M2 isoform of pyruvate kinase is involved in gastric cancer development by regulating cancer-specific metabolism.  Cancer Sci  2017  108(5):931-940  PubMed ID: 28235245   DOI: 10.1111/cas.13211
9931  Man Hagiyama, Norikazu Yabuta, Daisuke Okuzaki, Takao Inoue, Yasutoshi Takashima, Ryuichiro Kimura, Aritoshi Ri, Akihiko Ito  Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association With Cell Shape and Cytoskeletal Modifications  Front Physiol  2017  8:997  PubMed ID: 29259558   DOI: 10.3389/fphys.2017.00997
14585  Kikuchi M, Katoh H, Waraya M, Tanaka Y, Ishii S, Tanaka T, Nishizawa N, Yokoi K, Minatani N, Ema A, Kosaka Y, Tanino H, Yamashita K, Watanabe M.  Epigenetic silencing of HOPX contributes to cancer aggressiveness in breast cancer  Cancer Lett  2017  384:70-78  PubMed ID: 27756570   DOI: 10.1016/j.canlet.2016.10.017
14619  Kosuga T, Shiozaki A, Kudou M, Yamazato Y, Ichikawa D, Komatsu S, Konishi H, Okamoto K, Shoda K, Arita T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Nakanishi M, Fujiwara H, Marunaka Y, Otsuji E.  Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer  Oncotarget  2017  8(60):101394-101405  PubMed ID: 29254173   DOI: 10.18632/oncotarget.20736
14737  Baba K, Kitajima Y, Miyake S, Nakamura J, Wakiyama K, Sato H, Okuyama K, Kitagawa H, Tanaka T, Hiraki M, Yanagihara K, Noshiro H.  Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines  Sci Rep  2017  7(1):11127  PubMed ID: 28894280   DOI: 10.1038/s41598-017-11769-x
5815  Tamura F et al  RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells.  Gastric Cancer  2016  19(1):85-97  PubMed ID: 25532910   DOI: 10.1007/s10120-014-0454-z
6041  Tani R, Hayakawa K, Tanaka S, Shiota K.  Linker histone variant H1T targets rDNA repeats.  Epigenetics  2016  11(4):288-302  PubMed ID: 27018843   DOI: 10.1080/15592294.2016.1159369
12639  Yamashita K, Kuno A, Matsuda A, Ikehata Y, Katada N, Hirabayashi J, Narimatsu H, Watanabe M.  Lectin microarray technology identifies specific lectins related to lymph node metastasis of advanced gastric cancer  Gastric Cancer  2016  19(2):531-54  PubMed ID: 25840959   DOI: 10.1007/s10120-015-0491-2
12874  Altan B, Yokobori T, Ide M, Mochiki E, Toyomasu Y, Kogure N, Kimura A, Hara K, Bai T, Bao P, Suzuki M, Ogata K, Asao T, Nishiyama M, Oyama T, Kuwano H.  Nuclear PRMT1 expression is associated with poor prognosis and chemosensitivity in gastric cancer patients  Gastric Cancer  2016  19(3):789-97.  PubMed ID: 26472729   DOI: 10.1007/s10120-015-0551-7
12913  Arita T, Ichikawa D, Konishi H, Komatsu S, Shiozaki A, Ogino S, Fujita Y, Hiramoto H, Hamada J, Shoda K, Kosuga T, Fujiwara H, Okamoto K, Otsuji E.  Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells  Oncotarget  2016  7(35):56855-56863  PubMed ID: 27487135   DOI: 10.18632/oncotarget.10869
12951  Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, Morito K, Tanaka T, Shida M, Noshiro H.  Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer  Oncol Lett   2016  11(2):1026-1034.  PubMed ID: 26893686   DOI: 10.3892/ol.2015.4011
7097  Otsuka S, Matsumoto K, Nakajima M, Tanaka T, Ogura S.  Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia.  PLoS ONE  2015  10:e0146026  PubMed ID: 26717566   DOI: 10.1371/journal.pone.0146026
7334  Ito H, Hasegawa K, Hasegawa Y, Nishimaki T, Hosomichi K, Kimura S, Ohba M, Yao H, Onimaru M, Inoue I, Inoue H.  Silver Nanoscale Hexagonal Column Chips for Detecting Cell-free DNA and Circulating Nucleosomes in Cancer Patients.  Sci Rep  2015  5:10455  PubMed ID: 25994878   DOI: 10.1038/srep10455
5819  Yoshida K, Tsujimoto H, Matsumura K, Kinoshita M, Takahata R, Matsumoto Y, Hiraki S, Ono S, Seki S, Yamamoto J, Hase K.  CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer.  Cancer Med  2015  4(9):1322-33  PubMed ID: 26077800   DOI: 10.1002/cam4.478
14977  Suenaga M, Yamada S, Fuchs BC, Fujii T, Kanda M, Tanaka C, Kobayashi D, Fujiwara M, Tanabe KK, Kodera Y.  CD44 single nucleotide polymorphism and isoform switching may predict gastric cancer recurrence  J Surg Oncol  2015  112(6):622-8  PubMed ID: 26416034   DOI: 10.1002/jso.24056
15000  Sakamoto A, Akiyama Y, Shimada S, Zhu WG, Yuasa Y, Tanaka S.  DNA Methylation in the Exon 1 Region and Complex Regulation of Twist1 Expression in Gastric Cancer Cells  PLoS One  2015  10(12):e0145630  PubMed ID: 26695186   DOI: 10.1371/journal.pone.0145630
15037  Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, Ohi M, Inoue Y, Mohri Y, Goel A, Kusunoki M.  Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients  Carcinogenesis  2015  36(12):1474-83  PubMed ID: 26420253   DOI: 10.1093/carcin/bgv139
15159  Honda S, Loher P, Shigematsu M, Palazzo JP, Suzuki R, Imoto I, Rigoutsos I, Kirino Y.  Sex hormone-dependent tRNA halves enhance cell proliferation in breast and prostate cancers  Proc Natl Acad Sci U S A  2015  112(29):E3816-25  PubMed ID: 26124144   DOI: 10.1073/pnas.1510077112
3916  Okabe S, Okamoto T, Zhao CM, Chen D, Matsui H.  Acetic acid induces cell death: an in vitro study using normal rat gastric mucosal cell line and rat and human gastric cancer and mesothelioma cell lines.  J Gastroenterol Hepatol  2014  29 Suppl 4:65-9  PubMed ID: 25521736   DOI: 10.1111/jgh.12775
5830  Hirai S, Endo S, Saito R, Hirose M, Ueno T, Suzuki H, Yamato K, Abei M, Hyodo I.  Antitumor effects of a sirtuin inhibitor, tenovin-6, against gastric cancer cells via death receptor 5 up-regulation.  PLoS One  2014  9(7):e102831  PubMed ID: 25033286   DOI: 10.1371/journal.pone.0102831
15817  Endo F, Nishizuka SS, Kume K, Ishida K, Katagiri H, Ishida K, Sato K, Iwaya T, Koeda K, Wakabayashi G.  A compensatory role of NF-κB to p53 in response to 5-FU-based chemotherapy for gastric cancer cell lines  PLoS One  2014  9(2):e90155  PubMed ID: 24587255   DOI: 10.1371/journal.pone.0090155
16016  Nakamura A, Nakajima G, Okuyama R, Kuramochi H, Kondoh Y, Kanemura T, Takechi T, Yamamoto M, Hayashi K.  Enhancement of 5-fluorouracil-induced cytotoxicity by leucovorin in 5-fluorouracil-resistant gastric cancer cells with upregulated expression of thymidylate synthase  Gastric Cancer  2014  17(1):188-95  PubMed ID: 23494117   DOI: 10.1007/s10120-013-0249-7
5845  Konno-Shimizu M1, Yamamichi N, Inada K, Kageyama-Yahara N, Shiogama K, Takahashi Y, Asada-Hirayama I, Yamamichi-Nishina M, Nakayama C, Ono S, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K.  Cathepsin E is a marker of gastric differentiation and signet-ring cell carcinoma of stomach: a novel suggestion on gastric tumorigenesis.  PLoS One  2013  8(2):e56766  PubMed ID: 23451082   DOI: 10.1371/journal.pone.0056766
6075  Murakami H, Nakanishi H, Tanaka H, Ito S, Misawa K, Ito Y, Ikehara Y, Kondo E, Kodera Y.  Establishment and characterization of novel gastric signet-ring cell and non signet-ring cell poorly differentiated adenocarcinoma cell lines with low and high malignant potential.  Gastric Cancer  2013  16(1):74-83  PubMed ID: 22450770   DOI: 10.1007/s10120-012-0149-2
15081  Awazu Y, Nakamura K, Mizutani A, Kakoi Y, Iwata H, Yamasaki S, Miyamoto N, Imamura S, Miki H, Hori A.  A novel inhibitor of c-Met and VEGF receptor tyrosine kinases with a broad spectrum of in vivo antitumor activities  Mol Cancer Ther  2013  12(6):913-24  PubMed ID: 23548264   DOI: 10.1158/1535-7163.MCT-12-1011
15086  Katase N, Lefeuvre M, Tsujigiwa H, Fujii M, Ito S, Tamamura R, Buery RR, Gunduz M, Nagatsuka H.  Knockdown of Dkk-3 decreases cancer cell migration and invasion independently of the Wnt pathways in oral squamous cell carcinoma‑derived cells  Oncol Rep  2013  29(4):1349-55  PubMed ID: 23354949   DOI: 10.3892/or.2013.2251
5026  Waraya M, Yamashita K, Katoh H, Ooki A, Kawamata H, Nishimiya H, Nakamura K, Ema A, Watanabe M.  Cancer specific promoter CpG Islands hypermethylation of HOP homeobox (HOPX) gene and its potential tumor suppressive role in pancreatic carcinogenesis.  BMC Cancer  2012  12:397  PubMed ID: 22958219   DOI: 10.1186/1471-2407-12-397
5848  Kataoka Y, Mukohara T, Tomioka H, Funakoshi Y, Kiyota N, Fujiwara Y, Yashiro M, Hirakawa K, Hirai M, Minami H.  Foretinib (GSK1363089), a multi-kinase inhibitor of MET and VEGFRs, inhibits growth of gastric cancer cell lines by blocking inter-receptor tyrosine kinase networks.  Invest New Drugs  2012  30(4):1352-60  PubMed ID: 21655918   DOI: 10.1007/s10637-011-9699-0
5850  Miyato H, Tsuno NH, Kitayama J.  Semaphorin 3C is involved in the progression of gastric cancer.  Cancer Sci  2012  103(11):1961-6  PubMed ID: 22924992   DOI: 10.1111/cas.12003
5852  Tomioka H, Mukohara T, Kataoka Y, Ekyalongo RC, Funakoshi Y, Imai Y, Kiyota N, Fujiwara Y, Minami H.  Inhibition of the mTOR/S6K signal is necessary to enhance fluorouracil-induced apoptosis in gastric cancer cells with HER2 amplification.  Int J Oncol  2012  41(2):551-8  PubMed ID: 22614071   DOI: 10.3892/ijo.2012.1485
5855  Yang Y, Toy W, Choong LY, Hou P, Ashktorab H, Smoot DT, Yeoh KG, Lim YP.  Discovery of SLC3A2 cell membrane protein as a potential gastric cancer biomarker: implications in molecular imaging.  J Proteome Res  2012  11(12):5736-47  PubMed ID: 23116296   DOI: 10.1021/pr300555y
15742  Peng DF, Hu TL, Schneider BG, Chen Z, Xu ZK, El-Rifai W.  Silencing of glutathione peroxidase 3 through DNA hypermethylation is associated with lymph node metastasis in gastric carcinomas  PLoS One   2012  7(10):e46214  PubMed ID: 23071548   DOI: 10.1371/journal.pone.0046214
7876  Hiraki M, Kitajima Y, Koga Y, Tanaka T, Nakamura J, Hashiguchi K, Noshiro H, Miyazaki K.  Aberrant gene methylation is a biomarker for the detection of cancer cells in peritoneal wash samples from advanced gastric cancer patients.  Ann. Surg. Oncol.  2011  18:3013-9  PubMed ID: 21409489   DOI: 10.1245/s10434-011-1636-0
7990  Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.  Expression of BMP-7 in human gastric cancer and its clinical significance.  Br. J. Cancer  2011  104:714-8  PubMed ID: 21224856   DOI: 10.1038/sj.bjc.6606075
5866  Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, Miyazaki K.  Expression of hypoxic marker CA IX is regulated by site-specific DNA methylation and is associated with the histology of gastric cancer.  Am J Pathol  2011  178(2):515-24  PubMed ID: 21281785   DOI: 10.1016/j.ajpath.2010.10.010
6115  Kakimoto T, Shiraishi R, Iwakiri R, Fujimoto K, Takahashi H, Hamajima H, Mizuta T, Ideguchi H, Toda S, Kitajima Y, Ozaki I, Matsuhashi S.  Expression patterns of the tumor suppressor PDCD4 and correlation with β-catenin expression in gastric cancers.  Oncol Rep  2011  26(6):1385-92  PubMed ID: 21894439   DOI: 10.3892/or.2011.1450
16307  Ooki A, Yamashita K, Kikuchi S, Sakuramoto S, Katada N, Waraya M, Kawamata H, Nishimiya H, Nakamura K, Watanabe M.  Therapeutic potential of PRL-3 targeting and clinical significance of PRL-3 genomic amplification in gastric cancer  BMC Cancer  2011  11:122  PubMed ID: 21466710   DOI: 10.1186/1471-2407-11-122
5868  Tsunemi S, Nakanishi T, Fujita Y, Bouras G, Miyamoto Y, Miyamoto A, Nomura E, Takubo T, Tanigawa N.  Proteomics-based identification of a tumor-associated antigen and its corresponding autoantibody in gastric cancer.  Oncol Rep  2010  23(4):949-56  PubMed ID: 20204278   DOI: 10.3892/or_00000719
5874  Tu SP, Chi AL, Ai W, Takaishi S, Dubeykovskaya Z, Quante M, Fox JG, Wang TC.  p53 inhibition of AP1-dependent TFF2 expression induces apoptosis and inhibits cell migration in gastric cancer cells.  Am J Physiol Gastrointest Liver Physiol  2009  297(2):G385-96  PubMed ID: 19541923   DOI: 10.1152/ajpgi.90620.2008
5876  Takaishi S1, Okumura T, Tu S, Wang SS, Shibata W, Vigneshwaran R, Gordon SA, Shimada Y, Wang TC.  Identification of gastric cancer stem cells using the cell surface marker CD44.  Stem Cells.   2009  27(5):1006-20  PubMed ID: 19415765   DOI: 10.1002/stem.30
6410  Danjoh I, Sone H, Noda N, Iimura E, Nagayoshi M, Saijo K, Hiroyama T, Nakamura Y.  Is parainfluenza virus a threatening virus for human cancer cell lines?  Hum Cell  2009  22(3):81-4  PubMed ID: 19624309   DOI: 10.1111/j.1749-0774.2009.00071.x
6139  Jin SH, Akiyama Y, Fukamachi H, Yanagihara K, Akashi T, Yuasa Y.  IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells.  Int J Cancer  2008  122(5):1040-6  PubMed ID: 17957782   DOI: 10.1002/ijc.23181
3900  Miyagawa K, Sakakura C, Nakashima S, Yoshikawa T, Fukuda K, Kin S, Nakase Y, Shimomura K, Oue N, Yasui W, Hayasizaki H, Okazaki Y, Yamagishi H, Hagiwara A, Otsuji E.  Overexpression of RegIV in peritoneal dissemination of gastric cancer and its potential as A novel marker for the detection of peritoneal micrometastasis.  Anticancer Res  2008  28(2B):1169-79  PubMed ID: 18505053  
3581  Chang 1, Li W, Jia Z, Satou T, Fushiya S, Koike K.  Biologically active triterpenoid saponins from Ardisia japonica.  J Nat Prod  2007  70(2):179-87  PubMed ID: 17243725   DOI: 10.1021/np0604681
15600  Cheng YY, Yu J, Wong YP, Man EP, To KF, Jin VX, Li J, Tao Q, Sung JJ, Chan FK, Leung WK.  Frequent epigenetic inactivation of secreted frizzled-related protein 2 (SFRP2) by promoter methylation in human gastric cancer  Br J Cancer  2007  97(7):895-901  PubMed ID: 17848950   DOI: 10.1038/sj.bjc.6603968
5897  Kanaji S, Saito H, Tsujitani S, Matsumoto S, Tatebe S, Kondo A, Ozaki M, Ito H, Ikeguchi M.  Expression of polo-like kinase 1 (PLK1) protein predicts the survival of patients with gastric carcinoma.  Oncology  2006  70(2):126-33  PubMed ID: 16645325   DOI: 10.1159/000093003
3351  Sakakura, Chouhei, Hagiwara, Akeo, Miyagawa, Koji, Nakashima, Susumu, Yoshikawa, Tetsuji, Kin, Shuichi, Nakase, Yuenn, Ito, Kosei, Yamagishi, Hisakazu, Yazumi, Shujiro, Chiba, Tsutomu, Ito, Yoshiaki  Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer.  Int J Cancer  2005  113:221-8  PubMed ID: 15386419   DOI: 10.1002/ijc.20551
3167  Horie, Nobuyuki, Hirabayashi, Naomi, Takahashi, Yoshie, Miyauchi, Yuko, Taguchi, Hiroko, Takeishi, Keiichi  Synergistic effect of green tea catechins on cell growth and apoptosis induction in gastric carcinoma cells.  Biol Pharm Bull  2005  28:574-9  PubMed ID: 15802789   DOI: 10.1248/bpb.28.574
5919  Shizue Yoshioka, Shigeru Tatebe, Naruo Tokuyasu, Kenjiro Taniguchi, Yoshimi Ogami, Osamu Yamamoto, Keigo Ashida, Yoshihito Gomyo, Akira Kondo, Shunichi Tsujitani and Masahide Ikeguchi  The PI3K-Akt Pathway in SN-38-Induced Apoptosis in Human Gastric Cancer Cell Lines  Yonago Acta medica  2005  48:7–16   
12834  Lu H, Wu JY, Kudo T, Ohno T, Graham DY, Yamaoka Y.  Regulation of interleukin-6 promoter activation in gastric epithelial cells infected with Helicobacter pylori  Mol Biol Cell  2005  16(10):4954-66.  PubMed ID: 16030249   DOI: 10.1091/mbc.e05-05-0426
16808  Carl-McGrath S, Lendeckel U, Ebert M, Roessner A, Röcken C.  The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer  Int J Oncol  2005  26(1):17-24  PubMed ID: 15586220  
13707  Carl-McGrath S, Lendeckel U, Ebert M, Wolter AB, Roessner A, Röcken C.  The ectopeptidases CD10, CD13, CD26, and CD143 are upregulated in gastric cancer  Int J Oncol  2004  25(5):1223-32  PubMed ID: 15492809  



Back Back Return Top Page